Georg Hopfinger 3. Med.Abt and LBI for Leukemiaresearch and Haematology Hanusch Krankenhaus,Vienna, Austria
|
|
- Dominic Chase
- 6 years ago
- Views:
Transcription
1 Chronic lymphocytic Leukemia Georg Hopfinger 3. Med.Abt and LBI for Leukemiaresearch and Haematology Hanusch Krankenhaus,Vienna, Austria
2 CLL Diagnosis and Staging Risk Profile Assessment Choice of Therapy
3 Diagnosis is easy Lymphocytosis > 5000/ µl Cytology Immunology FISH
4 Staging according to Binet Lnd Hb Plt Spleen Liver A < 2 >10 > 100 B > 2 >10 > 100 C - < 10 < 100
5 Prognostic Factors Clinical Stage RAI or Binet Lymphocyte doubling time < 1 year Cytogenetics /molecularbiology 11q- or 17p- Deletion Unmutated IgV H -Status Labor/ Immunphenotype beta-2 Mikroglobulin Serum Thymidine Kinase CD 23 CD 38 ZAP 70
6 Clinical and molecular Parameters Questions : 1. Are they available? 2. Do they impact on therapy? 3. Predictive for Progression? 4. Predictive for Survival?
7 Survival according to Binet Stadium Probability of survival Binet stage A Binet stage B Binet stage C Time (Months)
8 Survival according to lymphocyte doubling time 1.0 Probability LDT > 12 months LDT < 12 months p< AD < 12 months Time (months) Mauro F, et al. Blood 1999;94:
9 Survival according to FISH and IGV H Mutation Status Genomic aberrations (n=325) 1 IgV H mutation status (n=211) 2, q del only 100 Survival (%) q del 12q trisomy Survival (%) Mutated p del Normal P < Unmutated Time (months) Time (months) 1. Dohner H, et al. N Engl J Med 2000;343: Rai K, et al. Hematology 2001: Krober A, et al. Blood 2002;100:
10 ZAP-70 Expression ZAP-70 expression and IgV H mutation status ZAP-70 expression and survival probability ZAP-70-positive cells (%) IgV H Mutated Unmutated 0 ZAP-70-positive cells (%) <95% 95 98% >98% Probability of survival (%) < 20% ZAP -70-positive cells 20% ZAP -70-positive cells p= IgV H Homology Year after diagnosis Crespo M, et al. N Engl J Med 2003;348:
11 PFS for del(17p) and del(11q) Grever, M. R. et al. J Clin Oncol; 25:
12 Therapy General considerations When? No: Asymptomatic Binet A ( only trials) Yes:Symptomatic Binet A &B, Binet C How? Performance Status? Aim? Cytogenetics?
13 Overall Survival Binet A chlorambucil vs no treatment Dighiero G et al. N Engl J Med 1998;338:
14 Mono Chemotherapy
15 Fludarabin 1st line n response(%) OS Rai FD vs CLB vs vs 56 NEJM 2000 (p=0.0001) French Cooperative FD vs CAP vs vs 24.5 Group Lancet 1996 Leporrier FD vs CHOP vs 71 vs vs 67 vs Blood 2001 CAP (p=0.0001) 70 Mo
16 Combination Chemotherapy
17 F vs FC Concerning CR % and Overall -Response % Fludarabin Fludarabin PFS Cyclophosphamide German trial 7/ / vs 48 Mo Eichhorst, Blood 2006 Uk trial 15/ / %vs 36% at 5 Yrs Catovsky,Lancet 2007 US trial 4,6/ / vs 31.6 Mo Flinn, JCO 2007
18 F vs FC PFS Eichhorst Blood 2006 Flinn,JCO 2007
19 Einfluss von 17p - nach F/FC Stilgenbauer ASH 2005
20 How can we further improve?
21 Monoclonal Antibodies in CLL HLA-DR CD52 slg CD20 CD23 MoAbs: Lymphocyte Anti CD 20 Rituximab Anti CD 52 Alemtuzumab Anti CD 23 Lumiliximab Adapted from Press O, et al. Cancer J Sci Am. 1998:4(suppl 2):s19 s26.
22 Rituximab monotherapy in CLL
23 Rituximab in relapsed CLL Huhn, D. et al. Blood 2001;98:
24 Lower ORR in CLL Patienten P=0.01 Possible causes: ORR (%) lower CD20 Expression lower Rituximab Serum levels higher Lymphocyte counts 0 FL SLL (CLL-type) Patients McLaughlin et al. J Clin Oncol. 1998;16:2825.
25 Dose Escalation 50 PatientS, CLL (with prior therapy) + other Rai III-IV Rai I-II with B Symptoms Dose 1 Dose 2-4 Kohorts n (mg/m2) (mg/m2) weekly A B C D E F O Brien et al. J Clin Oncol. 2001;19:2165.
26 Dose Escalation ORR CLL Patients 100 Response Rate (%) All CLL Patients (n=39)* (n=24)* (n=7)* (n=9)* * Evaluable patients. O Brien et al. J Clin Oncol. 2001;19:2165.
27 Rituximab + Chemo in relapsed /refractory CLL
28 FCR in relapsed CLL ORR: 73% CR: 25% PR (npr): 32% (16%) Molecular CR in 32% of CR Patients Fludarabin sensitive (n=108) Fludarabin resistant (n=37) ORR CR 31 5 npr PR Wierda et al., J Clin Oncol 2005;23:4070 8
29 FCR in relapsed CLL : TTP and OS No. of patients OS Died TTP Relapsed Probability Median OS 39 months Median TTP 28 months OS TTP Time (months) Wierda W, et al. J Clin Oncol 2005;23:4070 8
30 Rituximab in CLL first line
31 FR versus F in first -line CLL restrospective Comparison of 2 trials FR (CALGB 9712) vs F (CALGB 9011) F FR Patients (CALGB (CALGB 9011) 9712) N M Age (years) Rai III/IV (%) ECOG PS ORR (%) CR (%) p= p= 0.02 Byrd J, et al. Blood 2005;105:49 53.
32 FR vs F (retrospective) in first -line CLL PFS OS Probability FR Probability FR p< Time (months) F p= Time (months) F Byrd J, et al. Blood 2005;105:49 53.
33 FC-R first line in CLL 300 Patients 6 cycles R -FC every 4 weeks Keating M, et al. J Clin Oncol 2005;23: Response CR npr PR No response Early death 6-Year OS: 77% 6-Year FFS: 51% Patients (n) % % Tam C, et al. Blood 2008;15:112:
34 Overall survival and time to progression by treatment response Tam, C. S. et al. Blood 2008;112:
35 OS: historical Comparison R-FC 0.6 FC/FM Proportion F 0 Patients Died Treatment Fludarabine FC/FM R-FC Months Tam C, et al. Blood 2008;15:112:
36 CLL-8: R-FC vs FC in first line CLL untreated B -CLL Binet B with need for treatment or Binet C ECOG 0 1 N = 817 R A N D O M I S E R-FC q4wk 3 FC q4wk 3 R E S T A G E R-FC q4wk 3 CR, PR FC q4wk 3 MabThera Cycle 1: 375 mg/m 2 Cycle 2 6: 500 mg/m 2 Fludarabin 25 mg/m 2 iv, day 1 3 Cyclophosphamid 250 mg/m 2 iv, day 1 3 SD, PD off study
37 CLL-8: R-FC vs FC in first line CLL untreated B -CLL Binet B with need for treatment or Binet C ECOG 0 1 N = 817 R A N D O M I S E R-FC q4wk 3 FC q4wk 3 R E S T A G E R-FC q4wk 3 CR, PR FC q4wk 3 MabThera Cycle 1: 375 mg/m 2 Cycle 2 6: 500 mg/m 2 Fludarabin 25 Primary mg/m 2 iv, endpoint day 1 3 reached: > 35% SD, PD off study Cyclophosphamid PSF Benefit at two years! Data will be presented 250 mg/m 2 iv, at day ASH ,San Francisco EMEA accreditation pending
38 Future perspectives
39 Current Concepts of the DCLLSG CLL Binet A Asymptomatic CLL Binet C Symtomatic A and B CLL 7 CLL 2O CLL 10 17pwww.dcllsg.de
40 CLL7 Trial of the DCLLSG and French CLL Group Patients with Binet Stage A Aim and Rationale: complete eradication in high-risk patients Determination of risk factors: 1. 11q- or 17p- Deletion 2. Unmutated IgV H -Status 3. Serum TK > 10 U/L 4. LDT < 12 Mo Low risk: <2 Factors High risk:> 2 Faktors Observation FC+Rituximab Observation
Update on Management of CLL. Presenter Disclosure Information. Chronic Lymphocytic Leukemia. Audience Response Question?
Welcome to Master Class for Oncologists New York, NY May 14, 2010 Session 5: 4:20 PM - 5:00 PM Update on Management of CLL John C. Byrd, MD D Warren Brown Professor of Leukemia Research Professor of Medicine
More informationAddition of Rituximab to Fludarabine and Cyclophosphamide in Patients with CLL: A Randomized, Open-Label, Phase III Trial
Addition of Rituximab to Fludarabine and Cyclophosphamide in Patients with CLL: A Randomized, Open-Label, Phase III Trial Hallek M et al. Lancet 2010;376:1164-74. Introduction > In patients with CLL, the
More informationImproving Response to Treatment in CLL with the Addition of Rituximab and Alemtuzumab to Chemoimmunotherapy
New Evidence reports on presentations given at ASH 2009 Improving Response to Treatment in CLL with the Addition of Rituximab and Alemtuzumab to Chemoimmunotherapy From ASH 2009: Chronic Lymphocytic Leukemia
More informationMRD Negativity as an Outcome in CLL: Ongoing Challenges with Del 17p Patients
MRD Negativity as an Outcome in CLL: Ongoing Challenges with Del 17p Patients Jennifer R Brown, MD PhD Director, CLL Center Dana-Farber Cancer Institute Associate Professor Harvard Medical School November
More informationChronic Lymphocytic Leukemia (CLL): Refresher Course for Hematologists Ekarat Rattarittamrong, MD
Chronic Lymphocytic Leukemia (CLL): Refresher Course for Hematologists Ekarat Rattarittamrong, MD Division of Hematology Department of Internal Medicine Faculty of Medicine Chiang-Mai University Outline
More informationBackground. Approved by FDA and EMEA for CLL and allows for treatment without chemotherapy in all lines of therapy
Updated Efficacy and Safety From the Phase 3 RESONATE-2 Study: Ibrutinib As First-Line Treatment Option in Patients 65 Years and Older With Chronic Lymphocytic Leukemia/Small Lymphocytic Lymphoma Abstract
More informationASH up-date: Changing the Standard of Care for Patients with. (or: Who to treat with What When?)
ASH up-date: Changing the Standard of Care for Patients with B-cell Chronic Lymphocytic Leukaemia (or: Who to treat with What When?) Dr Anna Schuh, MD, PhD, MRCP, FRCPath Consultant and Senior Lecturer
More informationRaising the Bar in CLL Michael E. Williams, MD, ScM Byrd S. Leavell Professor of Medicine Chief, Hematology/Oncology Division
Raising the Bar in CLL Michael E. Williams, MD, ScM Byrd S. Leavell Professor of Medicine Chief, Hematology/Oncology Division University of Virginia Cancer Center The Clinical Continuum of CLL Early asymptomatic
More informationUpdate: Chronic Lymphocytic Leukemia
ASH 2008 Update: Chronic Lymphocytic Leukemia Improving Patient Response to Treatment with the Addition of Rituximab to Fludarabine-Cyclophosphamide ASH 2008: Update on chronic lymphocytic leukemia CLL-8
More informationCLL Ireland Information Day Presentation
CLL Ireland Information Day Presentation 5 May 2018 Professor Patrick Thornton Consultant Haematologist, Senior Lecturer RCSI, and Clinical Director Hermitage Medical Clinic Laboratory Chronic Lymphocytic
More informationFCR and BR: When to use, how to use?
FCR and BR: When to use, how to use? Mitchell R. Smith, M.D., Ph.D. Director of Lymphoid Malignancy Program Taussig Cancer Institute Cleveland Clinic, Cleveland, OH DEBATE ISSUE 2013: Which is the optimal
More informationAdvances in CLL 2016
Advances in CLL 2016 The Geoffrey P. Herzig Memorial Symposium, Louisville, KY Kanti R. Rai, MD Northwell-Hofstra School of Medicine Long Island Jewish Medical Center New Hyde Park, NY Disclosures Member
More informationRisikoprofil-gesteuerte, individualisierte Therapiestrategien bei der CLL. Michael Hallek University of Cologne
Risikoprofil-gesteuerte, individualisierte Therapiestrategien bei der CLL Michael Hallek University of Cologne 100 90 80 70 60 Substantial progress in CLL therapy in one decade 50 40 complete remissions
More informationThe legally binding text is the original French version TRANSPARENCY COMMITTEE OPINION. 6 October 2010
The legally binding text is the original French version TRANSPARENCY COMMITTEE OPINION 6 October 2010 ARZERRA 100 mg, concentrate for solution for infusion B/3 (CIP code: 577 117-9) B/10 (CIP code: 577
More informationCARE at ASH 2014 Lymphoma. Dr. Diego Villa Medical Oncologist British Columbia Cancer Agency Vancouver Cancer Centre
CARE at ASH 2014 Lymphoma Dr. Diego Villa Medical Oncologist British Columbia Cancer Agency Vancouver Cancer Centre High-yield lymphoma sessions Sat, Dec 6 th Sun, Dec 7 th Mon, Dec 8 th EDUCATIONAL SESSIONS
More informationCLL what do I need to know as an Internist in Taimur Sher MD Associate Professor of Medicine Mayo Clinic
CLL what do I need to know as an Internist in 218 Taimur Sher MD Associate Professor of Medicine Mayo Clinic Case 1 7 y/o white male for yearly medical evaluation Doing well and healthy Past medical history
More informationCLL & SLL: Current Management & Treatment. Dr. Peter Anglin
CLL & SLL: Current Management & Treatment Dr. Peter Anglin Chronic Lymphocytic Leukemia Prolonged clinical course Chronic A particular type of blood cell B lymphocyte Lymphocytic Cancer of white blood
More informationAktuelle Therapiestandards und neue Entwicklungen bei der CLL Primärtherapie und Risikostratifikation
Aktuelle Therapiestandards und neue Entwicklungen bei der CLL Primärtherapie und Risikostratifikation Dr. med. Petra Langerbeins Universitätsklinik Köln Deutsche CLL Studiengruppe (DCLLSG) OFFENLEGUNG
More informationChronic Lymphocytic Leukemia: Putting New Treatment Options Into Perspective
The diagnosis of CLL, the role of prognostic factors in determining treatment goals, and new first- and second-line treatment strategies are reviewed. Spider Web_13174. Photograph courtesy of Henry Domke,
More informationReviewed by Dr. Michelle Geddes (Staff Hematologist, University of Calgary) and Dr. Matt Cheung (Staff Hematologist, University of Toronto)
CLL Updated March 2017 by Doreen Ezeife Reviewed by Dr. Michelle Geddes (Staff Hematologist, University of Calgary) and Dr. Matt Cheung (Staff Hematologist, University of Toronto) DISCLAIMER: The following
More informationCLL: disease specific biology and current treatment. Dr. Nathalie Johnson
CLL: disease specific biology and current treatment Dr. Nathalie Johnson Disclosures Consultant and Advisory boards Roche, Abbvie, Gilead, Jansson, Lundbeck,Merck Research funding Roche, Abbvie, Lundbeck
More informationYounger patients with chronic lymphocytic leukemia benefit from rituximab treatment: A single center study in China
1266 Younger patients with chronic lymphocytic leukemia benefit from rituximab treatment: A single center study in China ZHENSHU XU, JINYAN ZHANG, SHUNQUAN WU, ZHIHONG ZHENG, ZHIZHE CHEN and RONG ZHAN
More informationCLL: What s New from ASH
CLL: What s New from ASH John C. Byrd, MD D. Warren Brown Chair in Leukemia Research Professor of Medicine and Medicinal Chemistry Director, Division of Hematology The Ohio State University 2 Chronic Lymphocytic
More informationNational Horizon Scanning Centre. Rituximab (MabThera) for chronic lymphocytic leukaemia. September 2007
Rituximab (MabThera) for chronic lymphocytic leukaemia This technology summary is based on information available at the time of research and a limited literature search. It is not intended to be a definitive
More informationA Canadian Perspective on the Management of Chronic Lymphocytic Leukemia
A Canadian Perspective on the Management of Chronic Lymphocytic Leukemia Douglas A. Stewart, MD, FRCP(C), 1 Christine Chen, MD, MEd, FRCP(C), 2 Laurie H. Sehn, MD, MPH, 3 Chaim Shustik, MD, FRCP(C) 4 1
More informationBiogen Idec Oncology Pipeline. Greg Reyes, MD, PhD SVP, Oncology Research & Development
Biogen Idec Oncology Pipeline Greg Reyes, MD, PhD SVP, Oncology Research & Development March 25, 2009 Biogen Idec Strategy in Lymphoma / Leukemia CLL RITUXAN NHL FC-RITUXAN GA101 RITUXAN-CVP RITUXAN-CHOP
More informationCLL & SLL: Current Management & Treatment. Dr. Isabelle Bence-Bruckler
CLL & SLL: Current Management & Treatment Dr. Isabelle Bence-Bruckler Chronic Lymphocytic Leukemia Prolonged clinical course Chronic A particular type of white blood cell B lymphocyte Lymphocytic Cancer
More informationClinical Overview: MRD in CLL. Dr. Matthias Ritgen UKSH, Medizinische Klinik II, Campus Kiel
Clinical Overview: MRD in CLL Dr. Matthias Ritgen UKSH, Medizinische Klinik II, Campus Kiel m.ritgen@med2.uni-kiel.de Remission in CLL Clinical criteria (NCI->WHO) Lymphadenopathy Splenomegaly Hepatomegaly
More informationQuando e se è possibile e u/le o0enere una remissione completa
Quando e se è possibile e u/le o0enere una remissione completa 1) Clinical heterogeneity Disease characteris:cs Pa:ent characteris:cs 2) Modern chemoimmunotherpy approaches 3) New mechanism- based treatment
More informationBENDAMUSTINE + RITUXIMAB IN CLL
BENDAMUSTINE + RITUXIMAB IN CLL Barbara Eichhorst Bologna 13. November 2017 CONFLICT OF INTERESTS 1. Advisory Boards Janssen, Gilead, Roche, Abbvie, GSK 2. Honoraria Roche, GSK, Gilead, Janssen, Abbvie,
More information1. What to test. 2. When to test
Biomarkers: the triad of questions 1. What to test 2. When to test 3. Who to test Biomarkers: the triad of questions 1. What to test 2. When to test 3. Who to test Impact of CLL biological features on
More informationCHRONIC LYMPHOCYTIC LEUKEMIA
CHRONIC LYMPHOCYTIC LEUKEMIA Effective Date: January, 2017 The recommendations contained in this guideline are a consensus of the Alberta Provincial Hematology Tumour Team synthesis of currently accepted
More informationMolecular Markers to Guide Therapy - Chronic Lymphocytic Leukaemia - Stephan Stilgenbauer Ulm University
Molecular Markers to Guide Therapy - Chronic Lymphocytic Leukaemia - Stephan Stilgenbauer Ulm University Chronic Lymphocytic Leukaemia (CLL) Most common leukaemia in adults Diagnosis straightforward CD19+/CD5+/CD23+
More informationCHRONIC LYMPHOCYTIC LEUKEMIA
CHRONIC LYMPHOCYTIC LEUKEMIA Effective Date: June, 2018 Copyright (2018) Alberta Health Services This material is protected by Canadian and other international copyright laws. All rights reserved. This
More informationChronic Lymphocytic Leukemia
Chronic Lymphocytic Leukemia Bruce D. Cheson, M.D. Head of Hematology Georgetown University Hospital Lombardi Comprehensive Cancer Center Washington, D.C. Chronic Lymphocytic Leukemia Most common type
More informationInvestor science event from ASH 2008 San Francisco, 9 December 2008
Investor science event from ASH 2008 San Francisco, 9 December 2008 Forward-looking statements This presentation contains certain forward-looking statements. These forward-looking statements may be identified
More informationInvestigation and Management of Chronic Lymphocytic Leukemia. James Johnston
Investigation and Management of Chronic Lymphocytic Leukemia James Johnston Site Specific Clinics CLL Clinic (787-4454) Erin Elphee BN James Johnston Rajat Kumar Matt Seftel (transplant) Myeloma Clinic
More informationL approccio terapeu-co. Maria Rosaria Villa U.O.C. Ematologia P.O. Ascalesi ASLNA1Centro
L approccio terapeu-co Maria Rosaria Villa U.O.C. Ematologia P.O. Ascalesi ASLNA1Centro DISCLOSURE Nome: Maria Rosaria Cognome: Villa Impiego nell industria farmaceu7ca negli ul7mi 5 anni: NO Interssi
More informationChronic lymphocytic leukemia
Chronic lymphocytic leukemia How the Experts Treat Hematologic Malignancies Las Vegas, NV 3/2018 Tanya Siddiqi, MD Assistant Professor City of Hope National Medical Center Duarte, CA DISCLOSURES I am on
More informationATTUALI APPROCCI TERAPEUTICI Dott. L. Trentin
II SESSIONE: LLC dalla Biologia alla Clinica ATTUALI APPROCCI TERAPEUTICI Dott. L. Trentin CONVEGNO INTERREGIONALE SIE PADOVA, 12 maggio 2011 Predicting clinical outcome in CLL: how and why survival from
More informationManagement of 17p Deleted CLL Patients in the Era of Targeted Therapy
Management of 17p Deleted CLL Patients in the Era of Targeted Therapy Jennifer R Brown, MD PhD Director, CLL Center Dana-Farber Cancer Institute Associate Professor Harvard Medical School November 11,
More informationAdverse Prognostic Features in Chronic Lymphocytic Leukemia
ONCOLOGY. Vol. 25 No. 8 REVIEW ARTICLE Adverse Prognostic Features in Chronic Lymphocytic Leukemia By Sarah Schellhorn Mougalian, MD 1, Susan O'Brien, MD 1 July 11, 2011 1 The University of Texas MD Anderson
More informationEfficacy of Bendamustine and rituximab in a real-world patient population
Efficacy of Bendamustine and rituximab in a real-world patient population Median follow-up 37,1 months Efficacy of bendamustine and rituximab as first salvage treatment in CLL and indirect comparison with
More informationManagement of Patients With Relapsed Chronic Lymphocytic Leukemia
Management of Patients With Relapsed Chronic Lymphocytic Leukemia Polina Shindiapina, MD, PhD, and Farrukh T. Awan, MD Abstract The management of chronic lymphocytic leukemia (CLL) has improved significantly
More informationHighlights in chronic lymphocytic leukemia
Congress Highlights CLL Highlights in chronic lymphocytic leukemia A. Janssens, MD, PhD 1 As new data on indolent non-hodgkin lymphoma (inhl) were not that compelling, only highlights on chronic lymphocytic
More informationLEUCEMIA LINFATICA CRONICA: TERAPIA DEL PAZIENTE IN RECIDIVA
CORSO TEORICO-PRATICO PER LA GESTIONE OTTIMALE DEI PAZIENTI AFFETTI DA LINFOMA MANTELLARE, LINFOMA FOLLICOLARE E LEUCEMIA LINFATICA CRONICA Torino, 21-23 Maggio 2018 LEUCEMIA LINFATICA CRONICA: TERAPIA
More informationChronic lymphocytic leukemia is eradication feasible and worthwhile?
Chronic lymphocytic leukemia is eradication feasible and worthwhile? Gianluca Gaidano, MD, PhD Division of Hematology Department of Clinical and Experimental Medicine Amedeo Avogardo University of Eastern
More informationCLL treatment algorithm and state of the art
CLL treatment algorithm and state of the art Davide Rossi, M.D., Ph.D. Hematology IOSI - Oncology Institute of Southern Switzerland IOR - Institute of Oncology Research Bellinzona - Switzerland CLL subgroups
More informationThe legally binding text is the original French version TRANSPARENCY COMMITTEE OPINION. 5 January 2011
The legally binding text is the original French version TRANSPARENCY COMMITTEE OPINION 5 January 2011 CHLORAMINOPHENE 2 mg, capsule B/30 (CIP code: 3369906) Applicant: TECHNI-PHARMA chlorambucil ATC code:
More informationDutch guidelines for diagnosis and treatment of chronic lymphocytic leukaemia 2011
r e v i e w Dutch guidelines for diagnosis and treatment of chronic lymphocytic leukaemia 2011 A.P. Kater 1,*, S. Wittebol 2, M.E.D. Chamuleau 3, M. van Gelder 4, M.H. J van Oers 1,*, on behalf of the
More informationSIMPOSIO - Leucemia Linfatica Cronica: presente e futuro nella gestione del paziente refrattario
42 Congresso Nazionale SIE 18-21 ottobre 2009 - Milano Convention Centre SIMPOSIO - Leucemia Linfatica Cronica: presente e futuro nella gestione del paziente refrattario Paolo Ghia Lab of B Cell Neoplasia
More informationCLL Biology and Initial Management. Gordon D. Ginder, MD Director, Massey Cancer Center Lipman Chair in Oncology
CLL Biology and Initial Management Gordon D. Ginder, MD Director, Massey Cancer Center Lipman Chair in Oncology CLL- Epidemiology Most common adult leukemia 25-30% in western world Incidence in US 4.5
More informationPublished Ahead of Print on February 13, 2012 as /JCO J Clin Oncol by American Society of Clinical Oncology
Published Ahead of Print on February 13, 212 as 1.12/JCO.211.36.9348 The latest version is at http://jco.ascopubs.org/cgi/doi/1.12/jco.211.36.9348 JOURNAL OF CLINICAL ONCOLOGY O R I G I N A L R E P O R
More informationIdelalisib in the Treatment of Chronic Lymphocytic Leukemia
Idelalisib in the Treatment of Chronic Lymphocytic Leukemia Jacqueline C. Barrientos, MD Assistant Professor of Medicine Hofstra North Shore LIJ School of Medicine North Shore LIJ Cancer Institute CLL
More informationGlobal warming in the leukaemia microenvironment: Chronic Lymphocytic Leukaemia (CLL) Nina Porakishvili
Global warming in the leukaemia microenvironment: Chronic Lymphocytic Leukaemia (CLL) Nina Porakishvili Working plan Case study; Epidemiology; Diagnosis; Immunobiology; Prognostication; Stratification
More informationNew Targets and Treatments for Follicular Lymphoma
Winship Cancer Institute of Emory University New Targets and Treatments for Follicular Lymphoma Jonathon B. Cohen, MD, MS Assistant Professor Div of BMT, Emory University Intro/Outline Follicular lymphoma,
More informationChronic lymphocytic Leukemia
Chronic lymphocytic Leukemia after IwCLL, ICML and EHA 2017 Ann Janssens, MD, PhD Hematology, UZ Leuven Brussels, 14 september 2017 Front line treatment CLL Active or progressive disease No active or progressive
More informationLEUCEMIA LINFATICA CRONICA
LEUCEMIA LINFATICA CRONICA Gianluca Gaidano SCDU Ematologia Dipartimento di Medicina Traslazionale Università del Piemonte Orientale Novara Outline CLL biology and pathogenesis Prognostication and prediction
More informationASH Spanning 50 years of ground-breaking research. Anniversary issue
C A n a d i a n V i s i o n f o r O n c o l o g y Number 11 February 2009 Anniversary issue ASH 2008 Spanning 50 years of ground-breaking research INSIDE THIS ISSUE CHRONIC LYMPHOCYTIC LEUKEMIA Improving
More informationREAL LIFE AMBULATORIALE E STUDI CLINICI RANDOMIZZATI NELLA PROGRAMMAZIONE TERAPEUTICA DELLA LEUCEMIA LINFATICA CRONICA.
REAL LIFE AMBULATORIALE E STUDI CLINICI RANDOMIZZATI NELLA PROGRAMMAZIONE TERAPEUTICA DELLA LEUCEMIA LINFATICA CRONICA Roberta Murru Struttura Complessa Ematologia e Centro Trapianti Presidio Ospedaliero
More informationMED B Form CLL. Johannes Schetelig. London 09/April/
www.ebmt.org MED B Form CLL Johannes Schetelig London 09/April/2013 Content Update on CLL (15 ) Experiment with mini MED B CLL Assessment of pre-treatment in CLL Cytogenetics in CLL What is the IGVH-Gene
More informationCME Information LEARNING OBJECTIVES
CME Information LEARNING OBJECTIVES Apply recent clinical research findings with the newly FDA-approved combination of obinutuzumab and chlorambucil to the management and care of patients with previously
More informationManagement of Chronic Lymphatic Leukemia Beyond conventional therapy
3 rd Young Hematologists Orientation Program SGPGI Lucknow August 18 th -19 th 218 Management of Chronic Lymphatic Leukemia Beyond conventional therapy Prof. Hari Menon. MD DM Department of Hemato-Oncology
More informationNATIONAL INSTITUTE FOR HEALTH AND CARE EXCELLENCE. Single Technology Appraisal. Ibrutinib for treating chronic lymphocytic leukaemia.
NATIONAL INSTITUTE FOR HEALTH AND CARE EXCELLENCE Single Technology Appraisal Ibrutinib for treating chronic lymphocytic leukaemia Final scope Remit/appraisal objective To appraise the clinical and cost
More informationResponse to the Questions from the Evidence Review Group
Response to the Questions from the Evidence Review Group STA : Fludarabine phosphate for 1st line treatment of Chronic Lymphocytic Leukaemia Schering Health Care Ltd **************************************************************************************************************************
More informationLEUKEMIA ANCO s ASH Highlights TOPICS
LEUKEMIA ANCO s ASH Highlights Bruno Medeiros, MD 02/10/2009 TOPICS CML Abstract 181 and 182 Abstract 186 and 335 CLL Abstract 325 and 45 APL Abstract 138 ALL Abstract 427 and 428 1 CML Rosti et al. High
More informationChronic Lymphocytic Leukemia: State of the Art
14th Annual INDY Hematology Review March 2017 Chronic Lymphocytic Leukemia: State of the Art Adrian Wiestner, MD/PhD Bethesda, MD awiestner@hotmail.com Disclosures Grant/research support: Pharmacyclics
More informationBR is an established treatment regimen for CLL in the front-line and R/R settings
Idelalisib plus bendamustine and rituximab (BR) is superior to BR alone in patients with relapsed/refractory CLL: Results of a phase III randomized double-blind placebo-controlled study Andrew D. Zelenetz,
More informationBrad S Kahl, MD. Tracks 1-21
I N T E R V I E W Brad S Kahl, MD Dr Kahl is Associate Professor and Director of the Lymphoma Service at the University of Wisconsin School of Medicine and Public Health and Associate Director for Clinical
More informationChronic Lymphocytic Leukemia: Prognostic Factors, Supportive Care Issues and Therapeutic Advances
Chronic Lymphocytic Leukemia: Prognostic Factors, Supportive Care Issues and Therapeutic Advances 2017 Master Class Course John C. Byrd, MD D Warren Brown Chair of Leukemia Research Distinguished University
More informationAdvances in the treatment of Chronic Lymphocytic Leukemia
Advances in the treatment of Chronic Lymphocytic Leukemia Lab of B Cell Neoplasia - Division of Experimental Oncology Strategic Research Program on CLL Department of Onco-Hematology Università Vita-Salute
More informationChronic Lymphocytic Leukemia Update. Learning Objectives
Chronic Lymphocytic Leukemia Update Ashley Morris Engemann, PharmD, BCOP, CPP Clinical Associate Adult Stem Cell Transplant Program Duke University Medical Center August 8, 2015 Learning Objectives Recommend
More informationFludarabine, Cyclophosphamide, and Multiple-Dose Rituximab as Frontline Therapy for Chronic Lymphocytic Leukemia
Fludarabine, Cyclophosphamide, and Multiple-Dose Rituximab as Frontline Therapy for Chronic Lymphocytic Leukemia Nicholas J. Short, MD 1 ; Michael J. Keating, MBBS 2 ; William G. Wierda, MD, PhD 2 ; Stefan
More informationCLL: future therapies. Dr. Nathalie Johnson
CLL: future therapies Dr. Nathalie Johnson Disclosures Consultant and Advisory boards Roche, Abbvie, Gilead, Jansson, Lundbeck,Merck Research funding Roche, Abbvie, Lundbeck Outline Treatment of relapsed
More informationBendamustine is Effective Therapy in Patients with Rituximab-Refractory, Indolent B-Cell Non-Hodgkin Lymphoma
Bendamustine is Effective Therapy in Patients with Rituximab-Refractory, Indolent B-Cell Non-Hodgkin Lymphoma Kahl BS et al. Cancer 2010;116(1):106-14. Introduction > Bendamustine is a novel alkylating
More informationUPDATES IN CHRONIC LYMPHOCYTIC LEUKEMIA TANYA SIDDIQI, MD
UPDATES IN CHRONIC LYMPHOCYTIC LEUKEMIA TANYA SIDDIQI, MD DISCLOSURE Speaker s bureau: Pharmacyclics, Janssen, Seattle Genetics, Astra Zeneca Consultant: Juno therapeutics, Astra Zeneca, BeiGene, Pharmacyclics
More informationBTK Inhibitors and BCL2 Antagonists
BTK Inhibitors and BCL2 Antagonists Constantine (Con) S. Tam Director of Haematology, St Vincent s Hospital Melbourne; Lead for Chronic Lymphocytic Leukemia and Indolent Lymphoma, Peter MacCallum Cancer
More informationNew Prognostic Markers in CLL
New Prognostic Markers in CLL Emili Montserrat The overall median survival of patients with chronic lymphocytic leukemia (CLL) is about 10 years. The individual prognosis is, however, extremely variable.
More informationSequencing of chronic lymphocytic leukemia therapies
CHRONIC LYMPHOCYTIC LEUKEMIA Sequencing of chronic lymphocytic leukemia therapies Jacqueline C. Barrientos CLL Research and Treatment Program, Department of Internal Medicine, Hofstra Northwell School
More informationThe case against maintenance rituximab in Follicular lymphoma. Jonathan W. Friedberg M.D., M.M.Sc.
The case against maintenance rituximab in Follicular lymphoma Jonathan W. Friedberg M.D., M.M.Sc. Follicular lymphoma: What are goals of treatment? Change natural history of disease: Decrease transformation
More informationChronic Lymphocytic Leukemia: Current Concepts
Review Chronic Lymphocytic Leukemia: Current Concepts EUN-MI YU 1, ADAM KITTAI 2 and IMAD A. TABBARA 1 1 Department of Hematology/ Oncology, George Washington University, Washington, DC, U.S.A.; 2 Department
More informationDebate Examining Controversies in the Front-line Management of CLL: Chemo-immunotherapy vs. Continuous TKI Therapy
Debate Examining Controversies in the Front-line Management of CLL: Chemo-immunotherapy vs. Continuous TKI Therapy Steven Coutre, MD Stanford Cancer Institute William G. Wierda, MD, PhD The University
More informationHeng Li, Wenjie Xiong, Huimin Liu, Shuhua Yi, Zhen Yu, Wei Liu, Rui Lyu, Tingyu Wang, Dehui Zou, Zengjun Li, Lugui Qiu
Original Article Serum LDH level may predict outcome of chronic lymphocytic leukemia patients with a 17p deletion: a retrospective analysis of prognostic factors in China Heng Li, Wenjie Xiong, Huimin
More informationAus der Medizinischen Klinik und Poliklinik III der Ludwig-Maximilians-Universität München. Direktor: Prof. Dr. W. Hiddemann
Aus der Medizinischen Klinik und Poliklinik III der Ludwig-Maximilians-Universität München Direktor: Prof. Dr. W. Hiddemann Disease-specific Complications of Chronic Lymphocytic Leukemia in Binet Stage
More informationNew Evidence reports on presentations given at EHA/ICML Bendamustine in the Treatment of Lymphoproliferative Disorders
New Evidence reports on presentations given at EHA/ICML 2011 Bendamustine in the Treatment of Lymphoproliferative Disorders Report on EHA/ICML 2011 presentations Efficacy and safety of bendamustine plus
More informationUNMET NEEDS OF PATIENTS WITH CLL/SLL AND FL. June 6, 2018
UNMET NEEDS OF PATIENTS WITH CLL/SLL AND FL June 6, 2018 0 PRESENTATION OVERVIEW IN CLL/SLL AND FL: Review patient heterogeneity and its connection to unmet needs Explore unmet needs within the CLL/SLL
More informationThe International Peer-Reviewed Journal for The the International Practicing Oncologist/Hematologist. Other Advances in Leukemia/MDS ALL AML MDS
The Oncologist The International Peer-Reviewed Journal for The the International Practicing Oncologist/Hematologist Peer-Reviewed Journal for the Practicing Oncologist/Hematologist 20 th Anniversary Overview
More informationCLL: MRD as a Surrogate Endpoint for Clinical Trials White Oak February 27, Chronic Lymphocytic Leukemia. Paolo Ghia
CLL: MRD as a Surrogate Endpoint for Clinical Trials White Oak February 27, 2013 Chronic Lymphocytic Leukemia Paolo Ghia CLL: MRD as a Surrogate Endpoint for Clinical Trials White Oak February 27, 2013
More informationInotuzumab Ozogamicin in ALL. Hagop Kantarjian M.D. May 2016 Bologna, Italy
Inotuzumab Ozogamicin in ALL Hagop Kantarjian M.D. May 2016 Bologna, Italy Immuno Oncology in ALL Monoclonals + cytotoxic agents e.g.inotuzumab Bispecific monoclonals (CD3 + CD19) e.g.blinatumomab Modified
More informationMantle cell lymphoma An update on management
Mantle cell lymphoma An update on management Dr Kim Linton Consultant Medical Oncologist The Christie NHS Foundation Trust 6 th October 2016 This educational meeting is organised and sponsored by Janssen-Cilag
More informationShort Telomeres Predict Poor Prognosis in Chronic Lymphocytic Leukemia
Short Telomeres Predict Poor Prognosis in Chronic Lymphocytic Leukemia L. Yang Internal Medicine Resident University of Manitoba Supervisor: Dr. J. Johnston Prognostic factors Clinical course is unpredictable
More informationChronische lymphatische Leukämie. Michael Hallek
Chronische lymphatische Leukämie Michael Hallek Themen Wandel der Prognose CLL8 Follow up CLLM1 Neue Substanzen Ibrutinib CAL101 CLL-Therapie 2013 Studien der DCLLSG Cancer 1981 Clinical Stage and Prognosis
More informationNovember 11, 2009 ONCOLOGY. Vol. 23 No. 12 Focus on Hematology Diagnosing and Treating Chronic Lymphocytic Leukemia in 2009
November 11, 2009 ONCOLOGY. Vol. 23 No. 12 Focus on Hematology Diagnosing and Treating Chronic Lymphocytic Leukemia in 2009 Matthew Kaufman, MD_Assistant Professor_Department of Medicine_Division of Hematology-
More informationDr Shankara Paneesha. ASH Highlights Department of Haematology & Stem cell Transplantation
ASH Highlights 2015 Themes of ASH 2015 Novel therapies - Myeloma AML Lymphoma Pd-L1 & PD-l inhibitors Emerging concepts in biology HIF-1a pathway Cautionary tales ASH Choosing Wisely list IFM/DFCI
More informationManagement of CLL in the Targeted Therapy Era
Management of CLL in the Targeted Therapy Era Jennifer A. Woyach, MD The Ohio State University The Ohio State University Comprehensive Cancer Center Arthur G. James Cancer Hospital and Richard J. Solove
More informationTherapy of CLL - where are we going?
CCK CancerCenterKarolinska Therapy of CLL - where are we going? An update on emerging therapeutic trends and safety aspects Anders Österborg Professor of Oncology Karolinska Institute and Hospital Stockholm,
More informationBiology and treatment of chronic lymphocytic leukemia
Annals of Oncology 16 (Supplement 2): ii113 ii123, 2005 doi:10.1093/annonc/mdi731 Biology and treatment of chronic lymphocytic leukemia P. Kokhaei, M. Palma, H. Mellstedt & A. Choudhury Departments of
More informationThe 1 World Congress on Controversies in Hematology (COHEM) Rome, September 2010
The 1 World Congress on Controversies in Hematology (COHEM) Rome, September 2010 Is the wait and watch philosophy still practical in the treatment of CLL even in younger patients? Expected to say NO Federico
More information12 th Annual Hematology & Breast Cancer Update Update in Lymphoma
12 th Annual Hematology & Breast Cancer Update Update in Lymphoma Craig Okada, MD, PhD Assistant Professor, Hematology January 14, 2010 Governors Hotel, Portland Oregon Initial Treatment of Indolent Lymphoma
More informationChronic Lymphocytic Leukaemia and Its Challenges for Insurers
Chronic Lymphocytic Leukaemia and Its Challenges for Insurers Sheetal Salgaonkar, M.D. Medical Director RGA Services India Private Limited Chronic lymphocytic leukaemia (CLL) is a slow-developing cancer
More information