ORIGINAL ARTICLE. DNA Repair Gene ERCC1 and ERCC2/XPD Polymorphisms and Risk of Squamous Cell Carcinoma of the Head and Neck
|
|
- Benjamin Hutchinson
- 6 years ago
- Views:
Transcription
1 ORIGINAL ARTICLE DNA Repair Gene ERCC1 and ERCC2/XPD Polymorphisms and Risk of Squamous Cell Carcinoma of the Head and Neck Erich M. Sturgis, MD; Kristina R. Dahlstrom, BS; Margaret R. Spitz, MD, MPH; Qingyi Wei, MD, PhD Objective: To determine the effect of the ERCC1 C8092A polymorphism and the ERCC2/XPD G23591A polymorphism on the risk of squamous cell carcinoma of the head and neck (SCCHN). Design: A hospital-based case-control study. Subjects: A total of 330 newly diagnosed case subjects with SCCHN and 330 cancer-free control subjects matched on age (±5 years), sex, smoking status, and alcohol use. All subjects were non-hispanic whites. Methods: After informed consent was obtained, blood was drawn for genotyping. The ERCC1 C8092A polymorphism was typed by single-strand conformational polymorphism analysis. The ERCC2/XPD G23591A polymorphism was typed by polymerase chain reaction based restriction fragment length polymorphism analysis with the enzyme StyI. The 2 analysis was used to assess differences in genotype and allele frequencies. Multivariate logistic regression analysis was performed to estimate the risk of SCCHN for individuals having these genotypes after adjustment for age, sex, tobacco smoking, and alcohol use. Results: The DNA was available and genotyping was ultimately successful for 313 case subjects and 313 control subjects. The ERCC1 8092CC genotype and the ERCC2/XPD 23591A allele were associated with nonsignificantly increased risks of SCCHN: odds ratios, 1.15 (95% confidence interval [CI], ) and 1.28 (95% CI, ), respectively, whereas having both risk genotypes was associated with an even higher risk of SCCHN: odds ratio, 1.78 (95% CI, ). When considering both polymorphisms, we found a significant allele dose effect (P=.04). Conclusions: These 2 polymorphisms may contribute to the risk of SCCHN, but larger studies are needed to confirm their role in SCCHN. Combining common DNA repair gene polymorphisms into models of genetic risk of SCCHN may improve risk estimates. Arch Otolaryngol Head Neck Surg. 2002;128: From the Departments of Head and Neck Surgery (Dr Sturgis) and Epidemiology (Drs Sturgis, Spitz, and Wei and Ms Dahlstrom), The University of Texas M. D. Anderson Cancer Center, Houston. ANNUAL ESTIMATES show that the number of current smokers in the United States has remained relatively stable at approximately 45 million over the past 3 decades, and the absolute incidence of newly diagnosed cancers has never exceeded 1.4 million. 1,2 These facts suggest that most smokers never develop cancer and that genetic differences probably influence individuals responses to environmental carcinogens and consequently their risk for cancer. Although the concept of genetic susceptibility may seem intuitive, it is extremely complex and involves multiple cellular systems regulated by hundreds of genes. It is unlikely that common genetic variants, most of which are single nucleotide polymorphisms (SNPs), will significantly influence risk without environmental exposures. Therefore, current efforts have focused on determining genotype frequencies in the population and which SNPs will be important to include in future, more complex, genetic models of cancer risk assessment. We have previously reported that the risk of squamous cell carcinoma of the head and neck (SCCHN) was associated with poor DNA repair phenotype in response to the classic tobacco carcinogen, benzo[a]pyrene diol epoxide. 3-6 The damage induced by it is repaired primarily by the nucleotide excision repair pathway. 7 In 1998, Shen et al 8 identified 31 SNPs of ERCC1, ERCC2/XPD, and ERCC4/XPF of the nucleotide excision repair pathway. Be- 1084
2 cause polymorphisms of the nucleotide excision repair genes may be associated with differences in DNA repair capacity, 9 we hypothesized that genetic variants in the nucleotide excision repair pathway may influence risk of SCCHN. In the present study, we examine an SNP of the 3 untranslated region (UTR) of ERCC1 that has been reported to be linked to adult-onset glioma, 10 and an SNP of exon 10 of ERCC2/XPD that has been linked to altered DNA repair capacity. 9 SUBJECTS, MATERIALS, AND METHODS STUDY SUBJECTS Between May 1995 and March 2001, patients with incident (newly diagnosed) SCCHN were recruited from patients seen in the Head and Neck Center at our institution to participate in an ongoing molecular epidemiologic study. After providing informed consent, all participating patients agreed to donate 30 ml of blood for biomarker testing and to complete a detailed questionnaire eliciting demographic, exposure, and family history information. Cancer-free control subjects were selected from a pool of healthy controls, identified from enrollees in a local managed-care organization, to participate in ongoing hospital-based case-control studies. The control subjects were matched to the case subjects on age (±5 years), sex, smoking status, and alcohol use. To eliminate the possibility of racial confounders, only non-hispanic whites were included in this study. Smokers were defined as those who had smoked more than 100 cigarettes in their lifetimes. Drinkers were defined as those who had drunk alcoholic beverages at least once a week for more than 1 year. GENOTYPING We used leukocyte cell pellets obtained from the buffy coat by centrifugation of 1 ml of whole blood for DNA extraction and performed polymerase chain reaction (PCR) amplification as previously described. 9,10 We used PCR assays to amplify the 3 UTR of ERCC1 and exon 10 of ERCC2/XPD, which contain the polymorphisms of interest. The primers used were 5 - TGAGCCAATTCAGCCACT-3 and 5 -TAGTTCCTCAGTTTC- CCG-3, which generate a 255 base pair (bp) fragment for the 3 UTR of ERCC1, and 5 -CTGTTGGTGGGTGCCCGTATC- TGTTGGTCT-3 and 5 -TAATATCGGGGCTCACCCTGCAG- CACTTCCT-3, which generate a 751-bp fragment for exon 10 of ERCC2/XPD. As previously described, 10 we used singlestrand conformational polymorphism assay to type the ERCC1 3 UTR polymorphism. The restriction enzyme StyI(NewEngland Biolabs, Beverly, Mass) was used to distinguish the polymorphism of exon 10 of ERCC2/XPD in which the gain of a StyI restriction site occurs in the polymorphic allele. The wildtype allele has a single StyI restriction site resulting in 2 bands (507 and 244 bp), and the polymorphic allele has 2 StyI restriction sites and, therefore, has 3 bands (474, 244, and 33 bp, not visible). The PCR product was digested with 10 U of StyI, in the 10 buffer supplied with the restriction enzyme and 2% bovine serum albumin at 37 C for 16 hours. The digestion products were separated on a 2% NuSieve 3:1 agarose gel (FMC Bio- Products, Rockland, Me) and photographed with Polaroid film (Cambridge, Mass). STATISTICAL ANALYSIS Table 1. Frequency Distribution Analysis of Demographic and Risk Factors* Variable Cases We first performed univariate analysis to calculate the frequency of each allele and genotype. By tabulation, we also examined the concordance between the genotype frequencies of 2 polymorphisms. We compared the observed genotype frequencies with those calculated from the Hardy-Weinberg equation (p2+2pq+q 2 =1, where p is the frequency of the wildtype allele and q is 1 p). We calculated the odds ratios (ORs) and their 95% confidence intervals (CIs) for the genotypes by logistic regression analysis with adjustment for age, sex, smoking status, and alcohol use. All of the statistical analyses were performed with Statistical Analysis System software (Version 6; SAS Institute Inc, Cary, NC). RESULTS Controls P Value Age, y (31.6) 98 (31.3) (35.2) 112 (35.8) (33.2) 103 (32.9) Sex Male 234 (74.8) 229 (73.2) Female 79 (25.2) 84 (26.8).65 Smoking status Smoker 235 (75.1) 230 (73.5) Nonsmoker 78 (24.9) 83 (26.5).65 Alcohol status Drinker 249 (79.5) 247 (78.9) Nondrinker 64 (20.5) 66 (21.1).84 Site Oral cavity 109 (34.8) Pharynx 145 (46.3) Larynx 59 (18.9) Two-sided 2 test. Includes 126 patients with oropharyngeal cancer and 19 patients with hypopharyngeal cancer. Initially, we identified 330 patients with SCCHN and 330 cancer-free control subjects. Of these, DNA was unavailable or PCR was unsuccessful in 17 patients and 17 control participants. Consequently, the ultimate sample size was 313 case subjects and 313 control subjects. The subjects were well matched on age, sex, smoking status, and alcohol use (Table 1). All subjects were non-hispanic whites. All cases were incident squamous cell carcinomas of the oral cavity, oropharynx, hypopharynx, or larynx (Table 1). Because only 19 patients with hypopharyngeal cancer were recruited, they were grouped with oropharyngeal patients for subgroup analysis. Genotype distributions are summarized in Table 2. The ERCC genotype distribution for case and control subjects were in Hardy-Weinberg equilibrium (P=.88 and P=.54, respectively). The variant ERCC1 8092A allele was less frequent in the case subjects (0.230) than in the control subjects (0.248), and the homozygous wildtype ERCC1 8092CC genotype was more common in the case group (58.5%) than in the control group (55.0%), suggesting the ERCC1 A allele has a protective effect. The ERCC2/XPD genotype distribution in case and control subjects were in Hardy-Weinberg equilibrium (P=
3 Table 2. ERCC and ERCC2/XPD Genotype/Allele Frequencies and Concordance* ERCC2/XPD G23591A Genotype Cases Controls ERCC1 C8092A Genotype GG GA AA All GG GA AA All CC 95 (30.4) 80 (25.6) 8 (2.6) 183 (58.5) 103 (32.9) 57 (18.2) 12 (3.8)* 172 (55.0) CA 26 (8.3) 78 (24.9) 12 (3.8) 116 (37.0) 38 (12.1) 69 (22.0) 20 (6.4) 127 (40.6) AA 2 (0.6) 7 (2.2) 5 (1.6) 14 (4.5) 1 (0.3) 9 (2.9) 4 (1.3) 14 (4.5) All 123 (39.3) 165 (52.7) 25 (8.0) 313 (100) 142 (45.4) 135 (43.1) 36 (11.5) 313 (100) *All data are number (percentage) of subjects. ERCC2/XPD 23591G allele frequency, 0.657/0.669 (cases/controls); ERCC2/XPD 23591A allele frequency, 0.343/0.331 (cases/controls). Test for Hardy-Weinberg equilibrium in the control subjects: P =.94. ERCC1 8092C allele frequency, 0.770/0.752 (cases/controls); ERCC1 8092A allele frequency; 0.230/0.248 (cases/controls). Test for Hardy-Weinberg equilibrium in the control subjects: P=.54. Table 3. ERCC and ERCC2/XPD Risk/Combination Genotype Frequencies and Risk Estimates* Genotype Cases Controls Odds Ratio (95% Confidence Interval) Crude Adjusted ERCC AA/AC 130 (41.5) 141 (45.1) CC 183 (58.5) 172 (54.9) 1.15 ( ) 1.15 ( ) ERCC2/XPD GG 123 (39.3) 142 (45.4) GA/AA 190 (60.7) 171 (54.6) 1.28 ( ) 1.28 ( ) Genotype combinations Neither ERCC1 8092CC nor ERCC2/XPD GA/AA 28 (9.0) 39 (12.5) Either ERCC1 8092CC or ERCC2/XPD GA/AA 197 (62.9) 205 (65.5) 1.34 ( ) 1.34 ( ) Both ERCC1 8092CC and ERCC2/XPD GA/AA 88 (28.1) 69 (22.0) 1.78 ( ) 1.78 ( ) Adjusted for age, sex, smoking status, and alcohol use. Trend test for the allele dose effect: P =.04. and P=.94, respectively). The variant ERCC2/XPD 23591A allele was more frequent in the case subjects (0.343) than in the control subjects (0.331), and the homozygous wildtype ERCC2/XPD 23591GG genotype was less common in the case group (39.3%) than in the control group (45.4%), suggesting that the ERCC2/XPD A allele increases risk. Risk estimates are summarized in Table 3. The ERCC1 8092CC genotype was associated with a borderline increased risk of SCCHN: adjusted OR, 1.15 (95% CI, ). The ERCC2/XPD 23591A allele was also associated with a borderline increased risk of SCCHN: adjusted OR, 1.28 (95% CI, ). Furthermore, having both of these risk genotypes (ie, both ERCC1 8092CC and ERCC2/XPD GA/AA) was associated with a significantly increased risk of SCCHN, and having only 1 risk genotype was associated with a borderline increased risk, suggesting an allele dose effect (trend test, P=.04). Subgroup analyses of the combined effect of ERCC1 8092CC and ERCC2/XPD GA/AA risk genotypes are summarized in Table 4. In smokers and drinkers, the risk estimates approached significance: adjusted OR for smokers, 1.46 (95% CI ) and for drinkers, 1.40 (95% CI; ). Furthermore, the combined risk genotype was associated with a significantly increased risk for pharyngeal cancer: adjusted OR, 1.59 (95% CI, ). COMMENT In this study, we assessed the risk of SCCHN associated with ERCC and ERCC2/XPD genotypes in a hospital-based, case-control analysis of 626 non- Hispanic white subjects closely matched on age, sex, smoking status, and alcohol use. Our findings were consistent with the prior report by Chen et al 10 of an association between ERCC1 8092CC and adult-onset glioma. The frequency of the variant ERCC1 8092A allele in our control subjects (0.248) was similar to the control group of Chen and colleagues (0.270). However, in that study, a significant risk associated with the ERCC1 8092CC genotype was found only in a glioma histologic subgroup of 28 oligoastrocytomas. 10 There are no other case-control data of tumor risk associated with the ERCC genotype. Our findings are also consistent with an association between the ERCC2/XPD 23591A allele and decreases in DNA repair capacity reported in a casecontrol study of lung cancer risk. 9 Although Lunn et al 11 reported that the ERCC2/XPD 23591A allele is associated with better DNA repair as measured by a cytogenetic assay of chromatid aberrations induced by irra- 1086
4 Table 4. Stratification Analysis of Combination Risk Genotype Frequencies, Odds Ratios, and 95% Confidence Intervals* Subjects With Both ERCC1 8092CC and ERCC2/XPD GA/AA Genotypes Odds Ratio (95% Confidence Interval) Variable Cases Controls Crude Adjusted Age, y (24.2) 23 (23.5) 1.04 ( ) 1.08 ( ) (29.1) 22 (19.6) 1.68 ( ) 1.67 ( ) (30.8) 24 (23.3) 1.46 ( ) 1.40 ( ) Sex Male 65 (27.8) 50 (21.8) 1.38 ( ) 1.39 ( ) Female 23 (29.1) 19 (22.6) 1.41 ( ) 1.41 ( ) Smoking status Smoker 66 (28.1) 49 (21.3) 1.44 ( ) 1.46 ( ) Nonsmoker 22 (28.2) 20 (24.1) 1.24 ( ) 1.24 ( ) Alcohol status Drinker 74 (29.7) 57 (23.1) 1.41 ( ) 1.40 ( ) Nondrinker 14 (21.9) 12 (18.2) 1.26 ( ) 1.26 ( ) Site Oral cavity 28 (25.7) 69 (22.0) 1.22 ( ) 1.21 ( ) Pharynx 45 (31.0) 69 (22.0) 1.59 ( ) 1.59 ( ) Larynx 15 (25.4) 69 (22.0) 1.21 ( ) 1.22 ( ) Adjusted for age, sex, smoking status, and alcohol use within each subgroup. diation, they assessed only 29 subjects, making genotyping subgroup analysis particularly subject to chance findings. In fact, they reported an ERCC2/XPD variant A allele frequency of 0.420, which is much higher than the we found in our 313 control subjects. Furthermore, ERCC2/XPD is a component of the nucleotide excision repair pathway, which is responsible for removal of tobacco-induced adducts and UV-induced dimers but not the repair of chromatid breaks induced by irradiation. In a study of 96 patients with lung cancer and 94 cancer-free controls, Butkiewicz et al 12 also suggested the ERCC2/XPD 23591A allele may have a potential protective effect, but a case-control analysis of adult-onset glioma found no association with the ERCC2/XPD genotype. 13 In comparison, the study by Spitz et al 9 of more than 450 subjects found that in the case subjects the ERCC2/XPD 23591A allele was associated with suboptimal DNA repair function as measured by the wellestablished host cell reactivation assay. 9 Such suboptimal DNA repair is associated with increased risk of lung cancer 14 and SCCHN. 3 These discrepancies in results between studies are obviously due to differences in sample sizes and the assays used. However, these results also suggest that these individual genotypes probably have only a modest effect on cancer risk, if any, and that more studies with larger samples are needed to clarify the role of these genotypes in cancer risk. Future genetic models will probably include multiple genotypes to significantly and reliably predict cancer risk. Furthermore, efforts to determine the effect of such polymorphisms on repair function must be encouraged. It is unlikely that such common genetic variants have a major effect on cancer risk independent of environmental exposures. The increased risk in those exposed to tobacco and alcohol suggests a potential geneenvironment effect. In other words, these genotypes may put individuals at increased risk only if they are also exposed to a carcinogen. Some epidemiological data suggest that tobacco and alcohol exposure may have a greater effect on pharyngeal cancer risk than on oral cavity or laryngeal cancer risk. 15 This may explain why we found these risk genotypes to be most common in the pharyngeal cancer subgroup. Regardless, these findings in subgroup analyses are preliminary, may be due to chance, and must be confirmed in larger studies. Accepted for publication February 13, This study is supported in part by start-up funds from The University of Texas M. D. Anderson Cancer Center (Dr Sturgis) and research grants CA (Dr Spitz), CA 70334, ES (Dr Wei), and CA (to M. D. Anderson Cancer Center) from the National Institutes of Health, National Cancer Institute, Bethesda, Md. This work was presented in part at the annual meeting of the American Head and Neck Society, Palm Desert, Calif, May 14-16, We thank Margaret Lung, RN, for assistance with recruiting patients; Maureen Goode, PhD, and Chris Yeager, BA, BS, for scientific editing; and Deanna Thomas, BS, for manuscript preparation. Corresponding author: Erich M. Sturgis, MD, Department of Head and Neck Surgery, Box 441, The University of Texas M. D. Anderson Cancer Center, 1515 Holcombe Blvd, Houston, TX ( REFERENCES 1. Giovino GA, Schooley MW, Zhu BP, et al. Surveillance for selected tobacco-use behaviors United States, Mor Mortal Wkly Rep CDC Surveill Summ. 1994;43(suppl S-3):
5 2. Greenlee RT, Hill-Harmon MB, Murray T, Thun M. Cancer statistics, CA Cancer J Clin. 2001;51: Cheng L, Eicher SA, Guo Z, Hong WK, Spitz MR, Wei Q. Reduced DNA repair capacity in head and neck cancer patients. Cancer Epidemiol Biomarkers Prev. 1998;7: Wang LE, Sturgis EM, Eicher SA, Spitz MR, Hong WK, Wei Q. Mutagen sensitivity to benzo[a]pyrene diol epoxide and the risk of squamous cell carcinoma of the head and neck. Clin Cancer Res. 1998;4: Li D, Firozi PF, Chang P, et al. In vitro BPDE-induced DNA adducts in peripheral lymphocytes as a risk factor for squamous cell carcinoma of the head and neck. Int J Cancer. 2001;93: Cheng L, Sturgis EM, Eicher SA, Spitz MR, Wei Q. Nucleotide excision repair gene expression and the risk for squamous cell carcinoma of the head and neck. Cancer. 2002;94: Hoeijmakers JHJ. Genome maintenance mechanisms for preventing cancer. Nature. 2001;411: Shen MR, Jones IM, Mohrenweiser H. Nonconservative amino acid substitution variants exist at polymorphic frequency in DNA repair genes in healthy humans. Cancer Res. 1998;58: Spitz MR, Wu X, Wang Y, et al. Modulation of nucleotide excision repair capacity by XPD polymorphisms in lung cancer patients. Cancer Res. 2001;61: Chen P, Wiencke J, Aldape K, et al. Association of an ERCC1 polymorphism with adult-onset glioma. Cancer Epidemiol Biomarkers Prev. 2000;9: Lunn RM, Helzlsouer KJ, Parsad R, et al. XPD polymorphisms: effects on DNA repair proficiency. Carcinogenesis. 2000;21: Butkiewicz D, Rusin M, Enewold L, Shield PG, Chorazy M, Harris CC. Genetic polymorphisms in DNA repair genes and risk of lung cancer. Carcinogenesis. 2001;22: Caggana M, Kilgallen J, Conroy JM, et al. Associations between ERCC2 polymorphisms and gliomas. Cancer Epidemiol Biomarkers Prev. 2001;10: Wei Q, Cheng L, Amos CI, et al. Repair of tobacco carcinogen-induced DNA adducts and lung cancer risk: a molecular epidemiologic study. J Natl Cancer Inst. 2000;92: Franceschi S, Talamini R, Barra S, et al. Smoking and drinking in relation to cancers of the oral cavity, pharynx, larynx, and esophagus in northern Italy. Cancer Res. 1990;50: Call for Photographs ARCHIVES OF OTOLARYNGOLOGY HEAD & NECK SURGERY Covers W ith the January 2001 issue, the ARCHIVES OF OTOLARYNGOLOGY introduced nonmedical photographs as cover art for the journal. We are bombarded with medical and technical information every minute of every day and this is our way of offering you, our readers, a moment to reflect, smile, breathe a little more deeply, maybe even escape for just a second and relax a bit. Do you have a scenic photograph you have taken that you think would make a great cover shot? We d love to see it! Submissions should be from our readers, reviewers, authors, or anyone affiliated with the journal, and MUST be formatted horizontally. They can be black and white or color and at least in but no larger than 8 10 in. If you wish to submit a digital photograph, please call our office at (404) for guidelines. Due to legal concerns, no recognizable people should appear in the picture, and please include details about where the picture was taken, how you happened to be there, and anything else you think is interesting about the image. We need the photographer s complete name, highest academic degree, city and state of residence, and a statement explaining how he or she is affiliated with the journal. Send submissions to ARCHIVES OF OTOLARYNGOLOGY, 1440 Clifton Rd NE, Suite 400, Atlanta, GA If you would like your photo returned, please enclose a self-addressed, stamped envelope. Cover photos will be chosen at the discretion of the ARCHIVES editorial staff. Michael M. E. Johns, MD Editor 1088
Association between ERCC1 and ERCC2 polymorphisms and breast cancer risk in a Chinese population
Association between ERCC1 and ERCC2 polymorphisms and breast cancer risk in a Chinese population R. Zhao and M.F. Ying Department of Pharmacy, Sir Run Run Shaw Hospital, School of Medicine, Zhejiang University,
More informationORIGINAL INVESTIGATION. DNA Repair in Lymphoblastoid Cell Lines From Patients With Head and Neck Cancer. genes.
ORIGINAL INVESTIGATION DNA Repair in Lymphoblastoid Cell Lines From Patients With Head and Neck Cancer Erich M. Sturgis, MD; Gary L. Clayman, DDS, MD; Yongli Guan, BA; Zhaozheng Guo, MD; Qingyi Wei, MD,
More informationAssociation between ERCC1 and ERCC2 gene polymorphisms and susceptibility to pancreatic cancer
Association between ERCC1 and ERCC2 gene polymorphisms and susceptibility to pancreatic cancer M.G. He, K. Zheng, D. Tan and Z.X. Wang Department of Hepatobiliary Surgery, Nuclear Industry 215 Hospital
More informationLack of association between ERCC5 gene polymorphisms and gastric cancer risk in a Chinese population
Lack of association between ERCC5 gene polymorphisms and gastric cancer risk in a Chinese population J.J. Lu, H.Q. Zhang, P. Mai, X. Ma, X. Chen, Y.X. Yang and L.P. Zhang Gansu Provincial Hospital, Donggang
More informationGLUTATHIONE-S-TRANSFERASE POLYMORPHISMS AND RISK OF SQUAMOUS-CELL CARCINOMA OF THE HEAD AND NECK
Int. J. Cancer (Pred. Oncol.): 84, 220 224 (999) 999 Wiley-Liss, Inc. GLUTATHIONE-S-TRANSFERASE POLYMORPHISMS AND RISK OF SQUAMOUS-CELL CARCINOMA OF THE HEAD AND NECK Publication of the International Union
More informationAssociation between ERCC1 and XPF polymorphisms and risk of colorectal cancer
Association between ERCC1 and XPF polymorphisms and risk of colorectal cancer H. Yang, G. Li and W.F. Li Departments of Radiation Oncology and Chemotherapy, The First Affiliated Hospital of Wenzhou Medical
More informationGenetic variability of genes involved in DNA repair influence treatment outcome in osteosarcoma
Genetic variability of genes involved in DNA repair influence treatment outcome in osteosarcoma M.J. Wang, Y. Zhu, X.J. Guo and Z.Z. Tian Department of Orthopaedics, Xinxiang Central Hospital, Xinxiang,
More informationIL10 rs polymorphism is associated with liver cirrhosis and chronic hepatitis B
IL10 rs1800896 polymorphism is associated with liver cirrhosis and chronic hepatitis B L.N. Cao 1, S.L. Cheng 2 and W. Liu 3 1 Kidney Disease Department of Internal Medicine, Xianyang Central Hospital,
More informationSmoking, human papillomavirus infection, and p53 mutation as risk factors in oropharyngeal cancer: a case-control study
RESEARCH FUND FOR THE CONTROL OF INFECTIOUS DISEASES Smoking, human papillomavirus infection, and p53 as risk factors in oropharyngeal cancer: a case-control study PKS Chan *, JSY Chor, AC Vlantis, TL
More informationAssociation between the -77T>C polymorphism in the DNA repair gene XRCC1 and lung cancer risk
Association between the -77T>C polymorphism in the DNA repair gene XRCC1 and lung cancer risk B.B. Sun, J.Z. Wu, Y.G. Li and L.J. Ma Department of Respiratory Medicine, People s Hospital Affiliated to
More informationPolymorphisms of XPC Gene And Susceptibility of Esophageal Cancer
www.springerlink.co Chin J Cancer Res 22(1):49-54, 2010 49 Original Article Polymorphisms of XPC Gene And Susceptibility of Esophageal Cancer Xiang-xian Feng 1, 2, Pei-fen Duan 2, Li-bing Wang 2, Zu-xun
More informationThe Breast Cancer Family Registry: Description of Resource and some Applications
The Breast Cancer Family Registry: Description of Resource and some Applications Mary Beth Terry, PhD Associate Professor Department of Epidemiology Mailman School of Public Health Overview of Talk Description
More informationInvestigation on ERCC5 genetic polymorphisms and the development of gastric cancer in a Chinese population
Investigation on ERCC5 genetic polymorphisms and the development of gastric cancer in a Chinese population L.Q. Yang 1, Y. Zhang 2 and H.F. Sun 3 1 Department of Gastroenterology, The Second Affiliated
More informationPolymorphisms of DNA repair-related genes with susceptibility and prognosis of prostate cancer
Polymorphisms of DNA repair-related genes with susceptibility and prognosis of prostate cancer X.J. Zhang, P. Liu and F. Zhu Urology Department, The First Affiliated Hospital of Xinxiang Medical University,
More informationGastroesophageal Reflux Disease and Odds of Head and Neck Squamous Cell Carcinoma in North Carolina
The Laryngoscope VC 2015 The American Laryngological, Rhinological and Otological Society, Inc. Gastroesophageal Reflux Disease and Odds of Head and Neck Squamous Cell Carcinoma in North Carolina Evan
More informationAssociation of polymorphisms of the xeroderma pigmentosum complementation group F gene with increased glioma risk
Association of polymorphisms of the xeroderma pigmentosum complementation group F gene with increased glioma risk W.K. Zhou 1, L.Y. Huang 1, L. Hui 1, Z.W. Wang 1, B.Z. Jin 1, X.L. Zhao 1, X.Z. Zhang 1,
More informationMyoglobin A79G polymorphism association with exercise-induced skeletal muscle damage
Myoglobin A79G polymorphism association with exercise-induced skeletal muscle damage T. Cui and M.S. Jiang College of Physical Education, Shandong University of Finance and Economics, Ji nan, Shandong,
More informationLung cancer remains the deadliest cancer worldwide despite
ORIGINAL ARTICLE ERCC2/XPD Lys751Gln and Asp312Asn Gene Polymorphism and Lung Cancer Risk A Meta-Analysis Involving 22 Case Control Studies Ping Zhan, MD,* Qin Wang, MD, Shu-Zhen Wei, MD, Jing Wang, MD,
More informationUNIVERSITY OF CALIFORNIA, LOS ANGELES
UNIVERSITY OF CALIFORNIA, LOS ANGELES BERKELEY DAVIS IRVINE LOS ANGELES MERCED RIVERSIDE SAN DIEGO SAN FRANCISCO UCLA SANTA BARBARA SANTA CRUZ DEPARTMENT OF EPIDEMIOLOGY SCHOOL OF PUBLIC HEALTH CAMPUS
More informationA PILOT STUDY OF HELICOBACTER PYLORI INFECTION AND RISK OF LARYNGOPHARYNGEAL CANCER
A PILOT STUDY OF HELICOBACTER PYLORI INFECTION AND RISK OF LARYNGOPHARYNGEAL CANCER Zhannat Z. Nurgalieva, MD, 1,2 David Y. Graham, MD, 1,2 Kristina R. Dahlstrom, BS, 3 Qingyi Wei, MD, PhD, 4 Erich M.
More informationAssociation between the XPG gene Asp1104His polymorphism and lung cancer risk
Association between the XPG gene Asp1104His polymorphism and lung cancer risk B. Zhou, X.M. Hu and G.Y. Wu Department of Thoracic Surgery, Hunan Provincial Tumor Hospital, Changsha, China Corresponding
More informationOriginal Article Association between XRCC1 and ERCC2 gene. polymorphisms and development of osteosarcoma.
Int J Clin Exp Pathol 2016;9(1):223-229 www.ijcep.com /ISSN:1936-2625/IJCEP0017837 Original Article Association between XRCC1 and ERCC2 gene polymorphisms and development of osteosarcoma Zimin Wang 1,
More informationSignificant Association of Ku80 Single Nucleotide Polymorphisms with Bladder Cancer Susceptibility in Taiwan
Significant Association of Ku80 Single Nucleotide Polymorphisms with Bladder Cancer Susceptibility in Taiwan CHAO-HSIANG CHANG 1,2*, CHANG-FANG CHIU 2,3*, SHIU-YUN LIANG 2*, HSI-CHIN WU 1,2, CHIA-LIN CHANG
More informationORIGINAL ARTICLE. US Mortality Rates for Oral Cavity and Pharyngeal Cancer by Educational Attainment
ORIGINAL ARTICLE US Mortality Rates for Oral Cavity and Pharyngeal Cancer by Educational Attainment Amy Y. Chen, MD, MPH; Carol DeSantis, MPH; Ahmedin Jemal, PhD Objective: To describe trends in mortality
More informationHPV is the most common sexually transmitted infection in the world.
Hi. I m Kristina Dahlstrom, an instructor in the Department of Head and Neck Surgery at The University of Texas MD Anderson Cancer Center. My lecture today will be on the epidemiology of oropharyngeal
More informationCommon obesity-related genetic variants and papillary thyroid cancer risk
Common obesity-related genetic variants and papillary thyroid cancer risk Cari M. Kitahara 1, Gila Neta 1, Ruth M. Pfeiffer 1, Deukwoo Kwon 2, Li Xu 3, Neal D. Freedman 1, Amy A. Hutchinson 4, Stephen
More informationInvestigating the role of polymorphisms in mir-146a, -149, and -196a2 in the development of gastric cancer
Investigating the role of polymorphisms in mir-146a, -149, and -196a2 in the development of gastric cancer Department of Gastrointestinal Surgery, Ren Ji Hospital, School of Medicine, Shanghai Jiao Tong
More informationAmerican Journal of EPIDEMIOLOGY
Volume 161 Number 1 January 1, 2005 American Journal of EPIDEMIOLOGY Copyright 2005 by The Johns Hopkins Bloomberg School of Public Health Sponsored by the Society for Epidemiologic Research Published
More informationInfluence of interleukin-18 gene polymorphisms on acute pancreatitis susceptibility in a Chinese population
Influence of interleukin-18 gene polymorphisms on acute pancreatitis susceptibility in a Chinese population H.B. Gui 1, X.G. Du 2, Z.H. Fu 3 and X.M. Chen 1 1 Department of Emergency, The First Affiliated
More informationInvestigation of the role of XRCC1 genetic polymorphisms in the development of gliomas in a Chinese population
Investigation of the role of XRCC1 genetic polymorphisms in the development of gliomas in a Chinese population S.C. Fan 1, J.G. Zhou 2 and J.Z. Yin 1 1 Department of Neurosurgery, The People s Hospital
More informationInfluence of interleukin-17 gene polymorphisms on the development of pulmonary tuberculosis
Influence of interleukin-17 gene polymorphisms on the development of pulmonary tuberculosis G.-C. Shi and L.-G. Zhang Department of Tuberculosis, The First Affiliated Hospital of Xinxiang Medical University,
More informationNew evidence of TERT rs polymorphism and cancer risk: an updated meta-analysis
JBUON 2016; 21(2): 491-497 ISSN: 1107-0625, online ISSN: 2241-6293 www.jbuon.com E-mail: editorial_office@jbuon.com ORIGINAL ARTICLE New evidence of TERT rs2736098 polymorphism and risk: an updated meta-analysis
More informationSupplementary Figure 1. Principal components analysis of European ancestry in the African American, Native Hawaiian and Latino populations.
Supplementary Figure. Principal components analysis of European ancestry in the African American, Native Hawaiian and Latino populations. a Eigenvector 2.5..5.5. African Americans European Americans e
More informationAdditions to the Medical Geologist s Toolbox
Additions to the Medical Geologist s Toolbox Application of Sensitive Biological Endpoints to Assess Human Exposure and Potential Health Effects at Low Environmental Contaminant Concentrations Malcolm
More informationAssociation between rs G<C gene polymorphism and susceptibility to pancreatic cancer in a Chinese population
Association between rs9904341 G
More informationVariants in DNA Repair Genes and Glioblastoma. Roberta McKean-Cowdin, PhD
Variants in DNA Repair Genes and Glioblastoma Advances in Bioinformatics and Genomics Symposium February 19, 2010 Roberta McKean-Cowdin, PhD Department of Preventive Medicine, University of Southern California
More informationH.F. Liu, J.S. Liu, J.H. Deng and R.R. Wu. Corresponding author: J.S. Liu
Role of XRCC1 gene polymorphisms in non-small cell lung cancer cisplatin-based chemotherapy, and their effect on clinical and pathological characteristics H.F. Liu, J.S. Liu, J.H. Deng and R.R. Wu Department
More informationDepartment of Respiratory Medicine, Zhengzhou Central Hospital Affiliated to Zhengzhou University, Zhengzhou, China
Association of glutathione S-transferase (GST) genetic polymorphisms with treatment outcome of cisplatin-based chemotherapy for advanced non-small cell lung cancer in a Chinese population H.L. Xiao 1,
More information2) Cases and controls were genotyped on different platforms. The comparability of the platforms should be discussed.
Reviewers' Comments: Reviewer #1 (Remarks to the Author) The manuscript titled 'Association of variations in HLA-class II and other loci with susceptibility to lung adenocarcinoma with EGFR mutation' evaluated
More informationAssociation of DNA Double strand Break Gene XRCC6 Genotypes and Lung Cancer in Taiwan
Association of DNA Double strand Break Gene XRCC6 Genotypes and Lung Cancer in Taiwan TE-CHUN HSIA 1,2,4, CHIN-JUNG LIU 1,3, CHIA-CHEN CHU 1,3, LIANG-WEN HANG 1,3, WEN-SHIN CHANG 1,5, CHIA-WEN TSAI 1,5,
More informationGene-Environment Interactions
Gene-Environment Interactions What is gene-environment interaction? A different effect of an environmental exposure on disease risk in persons with different genotypes," or, alternatively, "a different
More informationAssociation between IL-17A and IL-17F gene polymorphisms and risk of gastric cancer in a Chinese population
Association between IL-17A and IL-17F gene polymorphisms and risk of gastric cancer in a Chinese population W.M. Zhao 1, P. Shayimu 1, L. Liu 1, F. Fang 1 and X.L. Huang 2 1 Department of Gastrointestinal
More informationIncidence of HPV-Associated Head and Neck Cancers by Sub-site Among Diverse Racial/Ethnic Populations in the United States
Incidence of HPV-Associated Head and Neck Cancers by Sub-site Among Diverse Racial/Ethnic Populations in the United States Louisiana Tumor Registry LSUHSC School of Public Health Lauren Cole, MPH Linda
More informationInteraction between CYP 2C19*3 polymorphism and smoking in relation to laryngeal carcinoma in the Chinese Han population
Interaction between CYP 2C19*3 polymorphism and smoking in relation to laryngeal carcinoma in the Chinese Han population J. Feng 1,4 *, L. Li 2 *, Y.-S. Zhao 3, S.-Q. Tang 4, H.-B. Yang 4 and S.-X. Liu
More informationNIH Public Access Author Manuscript Am J Gastroenterol. Author manuscript; available in PMC 2008 March 17.
NIH Public Access Author Manuscript Published in final edited form as: Am J Gastroenterol. 2008 February ; 103(2): 360 367. XRCC2 and XRCC3 Gene Polymorphism and Risk of Pancreatic Cancer Li Jiao, Ph.D.
More informationOriginal Article The programmed death-1 gene polymorphism (PD-1.5 C/T) is associated with non-small cell lung cancer risk in a Chinese Han population
Int J Clin Exp Med 2014;7(12):5832-5836 www.ijcem.com /ISSN:1940-5901/IJCEM0002117 Original Article The programmed death-1 gene polymorphism (PD-1.5 C/T) is associated with non-small cell lung cancer risk
More informationHPV-Related Head and Neck Squamous Cancers
2015 Wisconsin Comprehensive Cancer Control Summit Aligning Partners, Priorities, and the Plan HPV-Related Head and Neck Squamous Cancers MCW Department of Otolaryngology and Communication Sciences MCW
More informationRESEARCH COMMUNICATION
ADH-2 and ALDH-2 Genotypes, Alcohol Drinking and Risk of Stomach Cancer in Chinese Males RESEARCH COMMUNICATION Alcohol Dehydrogenase-2 and Aldehyde Dehydrogenase-2 Genotypes, Alcohol Drinking and the
More informationCytochrome P450 2E1 RsaI/PstI and DraI Polymorphisms Are Risk Factors for Lung Cancer in Mongolian and Han Population in Inner Mongolia
www.springerlink.com Chin J Cancer Res 23(2): 107-111, 2011 107 Original Article Cytochrome 450 2E1 RsaI/stI and DraI olymorphisms Are Risk Factors for Lung Cancer in Mongolian and Han opulation in Inner
More informationCYP19 gene polymorphisms and the susceptibility to breast cancer in Xinjiang Uigur women
CYP19 gene polymorphisms and the susceptibility to breast cancer in Xinjiang Uigur women L. Yang, X.Y. Wang, Y.T. Li, H.L. Wang, T. Wu, B. Wang, Q. Zhao, D. Jinsihan and L.P. Zhu The Department of Mammary
More informationSupplementary Figure 1 Forest plots of genetic variants in GDM with all included studies. (A) IGF2BP2
Supplementary Figure 1 Forest plots of genetic variants in GDM with all included studies. (A) IGF2BP2 rs4402960, (B) MTNR1B rs10830963, (C) TCF7L2 rs7903146, (D) IRS1 rs1801278, (E) PPARG rs1801282, (F)
More informationAssociation between the CYP1A1 polymorphisms and hepatocellular carcinoma: a meta-analysis
Association between the CYP1A1 polymorphisms and hepatocellular carcinoma: a meta-analysis B.W. Yu 1 *, L.Q. Zhang 1 *, X.L. Teng 1, Y. Zhang 1, L.B. Zou 2 and H.Y. Ying 3 l Department of Clinical Laboratory,
More informationAward Number: W81XWH TITLE: CYP1B1 Polymorphism as a Risk Factor for Race-Related Prostate Cancer
AD Award Number: W81XWH-04-1-0579 TITLE: CYP1B1 Polymorphism as a Risk Factor for Race-Related Prostate Cancer PRINCIPAL INVESTIGATOR: Yuichiro Tanaka, Ph.D. Rajvir Dahiya, Ph.D. CONTRACTING ORGANIZATION:
More informationTITLE: CYP1B1 Polymorphism as a Risk Factor for Race-Related Prostate Cancer
AD Award Number: W81XWH-04-1-0579 TITLE: CYP1B1 Polymorphism as a Risk Factor for Race-Related Prostate Cancer PRINCIPAL INVESTIGATOR: Yuichiro Tanaka, Ph.D. CONTRACTING ORGANIZATION: Northern California
More informationA case-control study of the association of the polymorphisms and haplotypes of DNA ligase I with lung and upper-aerodigestive-tract cancers
Int. J. Cancer: 122, 163 1638 (28) ' 27 Wiley-Liss, Inc. A case-control study of the association of the polymorphisms and haplotypes of DNA ligase I with lung and upper-aerodigestive-tract cancers Yuan-Chin
More informationInfluence of ERCC2 gene polymorphisms on the treatment outcome of osteosarcoma
Influence of ERCC2 gene polymorphisms on the treatment outcome of osteosarcoma Z.F. Liu, A.L.J. Asila, K. Aikenmu, J. Zhao, Q.C. Meng and R. Fang Department of Orthopaedics, Chinese Medicine Hospital of
More informationXRCC1 Polymorphisms and Pancreatic Cancer: A Meta-Analysis
www.springerlink.com Chin J Cancer Res 23(3):165-170, 2011 165 Review Article XRCC1 Polymorphisms and Pancreatic Cancer: A Meta-Analysis Wei-dong Shen 1, Hong-lin Chen 2*, Peng-fei Liu 1 1 Department of
More informationBackground HPV causes virtually all cervical cancers HPV-16, Integration of viral oncogenes E6 and E7 Relationship between HPV and cervical cancer wou
Case-Control Control Study of Human Papillomavirus avi and Oropharyngeal Cancer D Souza, DSouza, et al. NEJM, May 2007 Tony Sung Julia Beaver Journal Club September 9, 2009 Background HPV causes virtually
More informationSystematic review on the association between ERCC1 rs and ERCC2 rs13181 polymorphisms and glioma risk
Systematic review on the association between ERCC1 rs3212986 and ERCC2 rs13181 polymorphisms and glioma risk C.X. Zhou 1 and J.H. Zhao 2 1 Department of Neurosurgery, Weifang People s Hospital, Weifang,
More informationGenetic polymorphisms and head and neck cancer risk (Review)
INTERNATINAL JURNAL F NCLGY 32: 945-973, 2008 945 Genetic polymorphisms and head and neck cancer risk (Review) TRU HIYAMA 1, MASAHARU YSHIHARA 1, SHINJI TANAKA 2 and KAZUAKI CHAYAMA 3 1 Health Service
More informationEpidemiology, Pathogenesis, and Prevention of Head and Neck Cancer
Epidemiology, Pathogenesis, and Prevention of Head and Neck Cancer Andrew F. Olshan Editor Epidemiology, Pathogenesis, and Prevention of Head and Neck Cancer Editor Andrew F. Olshan, Ph.D. Professor and
More informationSelection Bias in the Assessment of Gene-Environment Interaction in Case-Control Studies
American Journal of Epidemiology Copyright 2003 by the Johns Hopkins Bloomberg School of Public Health All rights reserved Vol. 158, No. 3 Printed in U.S.A. DOI: 10.1093/aje/kwg147 Selection Bias in the
More informationBladder Cancer Predisposition: A Multigenic Approach to DNA-Repair and Cell-Cycle Control Genes
Bladder Cancer Predisposition: A Multigenic Approach to DNA-Repair and Cell-Cycle Control Genes Xifeng Wu, 1 Jian Gu, 1 H. Barton Grossman, 2 Christopher I. Amos, 1 Carol Etzel, 1 Maosheng Huang, 1 Qing
More informationInvestigation of ERCC1 and ERCC2 gene polymorphisms and response to chemotherapy and overall survival in osteosarcoma
Investigation of ERCC1 and ERCC2 gene polymorphisms and response to chemotherapy and overall survival in osteosarcoma Q. Zhang 1, L.Y. Lv 1, B.J. Li 1, J. Zhang 1 and F. Wei 2 1 Department of Orthopaedics,
More informationInfluence of the c.1517g>c genetic variant in the XRCC1 gene on pancreatic cancer susceptibility in a Chinese population
Influence of the c.1517g>c genetic variant in the XRCC1 gene on pancreatic cancer susceptibility in a Chinese population Z.M. Zhao*, C.G. Li*, M.G. Hu, Y.X. Gao and R. Liu Department of Surgical Oncology,
More informationIntroduction to Genetics
Introduction to Genetics Table of contents Chromosome DNA Protein synthesis Mutation Genetic disorder Relationship between genes and cancer Genetic testing Technical concern 2 All living organisms consist
More informationTitle: DNA repair gene polymorphisms and risk of chronic atrophic gastritis: a case-control study
Author's response to reviews Title: DNA repair gene polymorphisms and risk of chronic atrophic gastritis: a case-control study Authors: Bernd Frank (b.frank@dkfz.de) Heiko Müller (h.mueller@dkfz.de) Melanie
More informationAssociation between XPD Lys751Gln polymorphism and risk of head and neck cancer: a meta-analysis
Association between XPD Lys751Gln polymorphism and risk of head and neck cancer: a meta-analysis H. Yuan, Y.M. Niu, R.X. Wang, H.Z. Li and N. Chen Institute of Dental Research, Nanjing Medical University,
More informationRESEARCH ARTICLE. Comprehensive Assessment of Associations between ERCC2 Lys751Gln/Asp312Asn Polymorphisms and Risk of Non- Hodgkin Lymphoma
RESEARCH ARTICLE Comprehensive Assessment of Associations between ERCC2 Lys751Gln/Asp312Asn Polymorphisms and Risk of Non- Hodgkin Lymphoma Jue-Yu Zhou 1& *, Li-Wen He 1,2&, Jie Liu 3, Hai-Lang Yu 1, Min
More informationRESEARCH ARTICLE. Hua-Yong Jiang 1&, Yong Zeng 2&, Wei-Dong Xu 1, Chuan Liu 3, Ya-Jie Wang 3 *, Ya-Di Wang 1 * Abstract.
RESEARCH ARTICLE Genetic Association between the XPG Asp1104His Polymorphism and Head and Neck Cancer Susceptibility: Evidence Based on a Meta-Analysis Hua-Yong Jiang 1&, Yong Zeng 2&, Wei-Dong Xu 1, Chuan
More informationAsingle inherited mutant gene may be enough to
396 Cancer Inheritance STEVEN A. FRANK Asingle inherited mutant gene may be enough to cause a very high cancer risk. Single-mutation cases have provided much insight into the genetic basis of carcinogenesis,
More informationInferring causality in observational epidemiology: Breast Cancer Risk as an Example
Inferring causality in observational epidemiology: Breast Cancer Risk as an Example Mary Beth Terry, PhD Department of Epidemiology and Environmental Sciences Cancer Genes vs Environmental Risk Factors
More informationSMOKING AND CANCER RISK
SMOKING AND CANCER RISK The effects of smoking on health were documented in a landmark report by the Surgeon General in 1964. Since then the devastating effect from smoking on millions of American lives
More informationAlcol e tumori con focus sulle basse dosi
Alcol e tumori con focus sulle basse dosi Carlo La Vecchia Department of Epidemiology, Istituto Mario Negri Department of Clinical Sciences and Community Health, Università degli Studi di Milano 1 Cancers
More informationOriginal Article ERCC5 rs polymorphism is the risk factor for sporadic breast cancer in Thailand
Int J Mol Epidemiol Genet 2018;9(4):27-33 www.ijmeg.org /ISSN:1948-1756/IJMEG0077982 Original Article ERCC5 rs751402 polymorphism is the risk factor for sporadic breast cancer in Thailand Malinee Pongsavee
More informationA common genetic variant of 5p15.33 is associated with risk for prostate cancer in the Chinese population
A common genetic variant of 5p15.33 is associated with risk for prostate cancer in the Chinese population Q. Ren 1,3 *, B. Xu 2,3 *, S.Q. Chen 2,3 *, Y. Yang 2,3, C.Y. Wang 2,3, Y.D. Wang 2,3, X.H. Wang
More informationLack of association of IL-2RA and IL-2RB polymorphisms with rheumatoid arthritis in a Han Chinese population
Lack of association of IL-2RA and IL-2RB polymorphisms with rheumatoid arthritis in a Han Chinese population J. Zhu 1 *, F. He 2 *, D.D. Zhang 2 *, J.Y. Yang 2, J. Cheng 1, R. Wu 1, B. Gong 2, X.Q. Liu
More informationWojciech K. Mydlarz, M.D. Pharyngocutaneous Fistulas after Salvage Laryngectomy: Need for Vascularized Tissue
Wojciech K. Mydlarz, M.D. Pharyngocutaneous Fistulas after Salvage Laryngectomy: Need for Vascularized Tissue Disclosures No Relevant Financial Relationships or Commercial Interests Educational Objectives
More informationAssociation between the pre-mir-196a2 rs polymorphism and gastric cancer susceptibility in a Chinese population
Association between the pre-mir-196a2 rs11614913 polymorphism and gastric cancer susceptibility in a Chinese population M. Li, R.J. Li, H. Bai, P. Xiao, G.J. Liu, Y.W. Guo and J.Z. Mei Department of Medical
More informationCYP1A2-163C/A (rs762551) polymorphism and bladder cancer risk: a case-control study
CYP1A2-163C/A (rs762551) polymorphism and bladder cancer risk: a case-control study Y.L. Song 1,2, L. Wang 2, J.C. Ren 1 and Z.H. Xu 1 1 Department of Urology, Qilu Hospital, Shandong University, Jinan,
More informationA Local Mechanism by which Alcohol Consumption Causes Cancer
Essay A Local Mechanism by which Alcohol Consumption Causes Cancer Miguel López-Lázaro Department of Pharmacology, Faculty of Pharmacy, University of Seville, C/ Profesor Garcia Gonzalez 2, 41012 Sevilla,
More informationInvestigation of Programmed Cell Death-1 (PD-1) Gene Variations at Positions PD1.3 and PD1.5 in Iranian Patients with Non-small Cell Lung Cancer
Original Article Middle East Journal of Cancer; January 2018; 9(1): 13-17 Investigation of Programmed Cell Death-1 (PD-1) Gene Variations at Positions PD1.3 and PD1.5 in Iranian Patients with Non-small
More informationRole of TGFB1 polymorphism in the development of metastatic brain tumors in non-small cell lung cancer patients
Role of TGFB1 polymorphism in the development of metastatic brain tumors in non-small cell lung cancer patients H.B. Wang, W.G. Song, H.Q. Liu, F. Fang and Y. Xiao Department of Radiotherapy and Chemotherapy
More informationCutting Edge Research Plenary
Cutting Edge Research Plenary Xin Shelley Wang, MD MPH, MD Anderson Cancer Center, Houston, TX, United States Amylou C. Dueck, PhD, Mayo Clinic, Scottsdale, AZ, United States John P. Barile, PhD, Univ.
More informationSMOKING AND CANCER RISK
SMOKING AND CANCER RISK The effects of smoking on health were documented in a landmark report by the Surgeon General in 1964. Since then the devastating effect from smoking on millions of American lives
More informationLack of Association of Alcohol and Tobacco with HPV16-Associated Head and Neck Cancer
ARTICLE Lack of Association of Alcohol and Tobacco with HPV16-Associated Head and Neck Cancer Katie M. Applebaum, C. Sloane Furniss, Ariana Zeka, Marshall R. Posner, Judith F. Smith, Janine Bryan, Ellen
More informationPooled analysis of association between a genetic variant in the 3'-untranslated region of Toll-like receptor 4 and cancer risk
Pooled analysis of association between a genetic variant in the 3'-untranslated region of Toll-like receptor 4 and cancer risk X. Wang*, Z. Xu* and C.H. Miao Department of Anesthesiology, Shanghai Cancer
More informationInvestigation on the role of XPG gene polymorphisms in breast cancer risk in a Chinese population
Investigation on the role of XPG gene polymorphisms in breast cancer risk in a Chinese population S.H. Ma 1,2, F.H. Ling 2, Y.X. Sun 3, S.F. Chen 2 and Z. Li 1 1 Department of General Surgery, Zhujiang
More informationDisparities in Oral and Pharyngeal Cancer Incidence and Mortality Among Wisconsin Residents,
Disparities in Oral and Pharyngeal Cancer Incidence and Mortality Among Wisconsin Residents, 1999-22 Ashly McLean, BS; Warren LeMay, DDS, MPH; Peter Vila, BS; Mark Wegner, MD, MPH; Patrick Remington, MD,
More informationOriginal Article Association of NER pathway gene polymorphisms with susceptibility to laryngeal cancer in a Chinese population
Int J Clin Exp Pathol 2015;8(9):11615-11621 www.ijcep.com /ISSN:1936-2625/IJCEP0010057 Original Article Association of NER pathway gene polymorphisms with susceptibility to laryngeal cancer in a Chinese
More informationEnvironmental Management & Pollution Environmental and Chemical Carcinogenesis
Environmental Management & Pollution Environmental and Chemical Carcinogenesis 8.1 Abstract People are continuously exposed exogenously to varying amounts of chemicals that have been shown to have carcinogenic
More informationRole of Paired Box9 (PAX9) (rs ) and Muscle Segment Homeobox1 (MSX1) (581C>T) Gene Polymorphisms in Tooth Agenesis
EC Dental Science Special Issue - 2017 Role of Paired Box9 (PAX9) (rs2073245) and Muscle Segment Homeobox1 (MSX1) (581C>T) Gene Polymorphisms in Tooth Agenesis Research Article Dr. Sonam Sethi 1, Dr. Anmol
More informationLow risk of second primary malignancies among never smokers with human papillomavirus associated index oropharyngeal cancers
ORIGINAL ARTICLE Low risk of second primary malignancies among never smokers with human papillomavirus associated index oropharyngeal cancers Brandon W. Peck, BS, 1,2 Kristina R. Dahlstrom, MS, 1 Samuel
More informationGenetic variability of DNA repair mechanisms in chemotherapy treatment outcome of gastric cancer patients
Genetic variability of DNA repair mechanisms in chemotherapy treatment outcome of gastric cancer patients G. Zhong 1, H.K. Li 2, T. Shan 1 and N. Zhang 1 1 Department of Gastrointestinal Surgery, Tianjin
More informationPolymorphism of the PAI-1gene (4G/5G) may be linked with Polycystic Ovary Syndrome and associated pregnancy disorders in South Indian Women
www.bioinformation.net Volume 13(5) Hypothesis Polymorphism of the PAI-1gene (4G/5G) may be linked with Polycystic Ovary Syndrome and associated pregnancy disorders in South Indian Women Maniraja Jesintha
More informationAberrant DNA methylation of MGMT and hmlh1 genes in prediction of gastric cancer
Aberrant DNA methylation of MGMT and hmlh1 genes in prediction of gastric cancer J. Jin 1,2, L. Xie 2, C.H. Xie 1 and Y.F. Zhou 1 1 Department of Radiation & Medical Oncology, Zhongnan Hospital of Wuhan
More informationPolymorphism of XRCC1 Gene Exon 6 (Arg194Trp) in Relation to Micronucleus Frequencies in Hospital Radiation Workers
Atom Indonesia Vol. 44 No. 2 (218) 15-111 N. Adventini et al. / Atom Indonesia Vol. 43 No. xxx (217) xxx - xxx Atom Indonesia Journal homepage: http://aij.batan.go.id Polymorphism of XRCC1 Gene Exon 6
More informationA meta-analysis of alcohol drinking and cancer risk
British Journal of Cancer (200) 85(), 700 705 doi: 0.054/ bjoc.200.240, available online at http://www.idealibrary.com on http://www.bjcancer.com A meta-analysis of alcohol drinking and cancer risk V Bagnardi,
More informationRESEARCH ARTICLE. Association of Poly (ADP-Ribose) Polymerase 1 Variants with Oral Squamous Cell Carcinoma Susceptibility in a South Indian Population
RESEARCH ARTICLE Association of Poly (ADP-Ribose) Polymerase 1 Variants with Oral Squamous Cell Carcinoma Susceptibility in a South Indian Population Sukumaran Anil 1, PB Gopikrishnan 2, Ashik Bin Basheer
More informationFrequency of XRCC1 Exon 9 G>A gene polymorphism in Saudi Arabian population: A comparative study with worldwide
JBUON 2018; 23(4): 1195-1199 ISSN: 1107-0625, online ISSN: 2241-6293 www.jbuon.com E-mail: editorial_office@jbuon.com ORIGINAL ARTICLE Frequency of XRCC1 Exon 9 G>A gene polymorphism in Saudi Arabian population:
More information