The Stem-Cell Cocktail

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1 GIL 2012: RUSSIA The Global Community of Growth, Innovation and Leadership A Novel Therapy for the Treatment of Leukemia and Cancer The Stem-Cell Cocktail Steve Shor Founder & Executive Director NCLF Cancer Research Center Brian Denker Vice President & Global Head Growth, Innovation and Leadership Frost & Sullivan

2 Cancer is dynamic & adaptive. Providing the Cure Why is cancer so challenging? Cancer is strong & resilient. Cancer is complex & innovative. Cancer is opportunistic.

3 The Typical Question: In what ways does the typical cancer cell differ from the normal cell? The BIG Question The NCLF Question What are the mechanisms that foster growth in cancer cells? Are there multiple pathways of growth? How does the cancer cell harness the energy of the human body to facilitate growth?

4 NCLF Bio Medical Research Center

5 Cancer/Leukemia cells Providing the Cure The Stem Cell & Cancer Interaction Paradigm Molecular pathways analysis Adult Stem Cells

6 Unleashing the Potential of Stem Cells in Cancer Therapy Cancer -Stem cell Interaction Paradigm Identify target molecular pathways regulating cancer cell growth & development Design of interventions using multiple target molecular pathways Addressing the complexity of cancer development and diversity

7 Combination Therapy Approach Pathway #1 Pathway #3 Pathway #2

8 Compound #2 Compound # 3 Stem Cells Multiple Pathways Multiple Targets Multiple Compounds

9 Growth Inhibition of Leukemia Cells using Stem Cell Cocktail Therapy Growth inhibition of Leukemia cells after 72h of culture Viable cell number (OD) (in vitro results) Control Compound A Compound B Compound C "Cocktail" (A+B+C)

10 Stem Cell Cocktail A Therapy to Treat Cancer (in vivo results) Survival of Leukemia harboring animals treated with Adult stem cells Fraction survival Days control SC treated P<0.0001

11 A Cure IS POSSIBLE in our Generation National Children s Leukemia Foundation Use of Mesenchymal Stem Cells for the Treatment of Leukemia United States Provisional Patent Application #61/564,317 November 29, 2011

12 Trajectory of Progress Clinical Trials Pre-Clinical Trials *Testing Additional Combinations *Creating additional Cocktails *Expanding the paradigm to other cancer types.

13 The Cure IS Within Our Reach Explore these advancements in cancer research further, be apart of it. Determine how you too can help NCLF to contribute to these advancements. Make a Difference Find your visionary innovation, support each other, members of the GIL Community and it s global partners contributing and changing the world.

14 GIL 2012: Beyond the Journey to Visionary Innovation Next Steps Share, Engage and Inspire 24x365 via the online GIL Community Schedule a one-on-one Growth Strategic Dialogue Develop Your Visionary and Innovative Skills Growth Partnership Service Leverage the GTL in your monthly GIL Community Newsletter (GCN) Envision Your Future and Succeed with Growth Workshops Get Your Entire Team Innovating to Zero with an on-site Mega Trends Workshop

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