CD31 Monoclonal Antibody (JC/70A) Catalog Number

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1 Website: thermofisher.com Customer Service (US): ext. 1 Technical Support (US): ext. 441 CD31 Monoclonal Antibody (JC/70A) Catalog Number Details MA Size 500 µl Host/Isotope Class Type Clone Immunogen Conjugate Form Storage buffer Contains Storage Conditions Mouse / IgG1, kappa Monoclonal Antibody JC/70A Membrane preparation of a spleen from a patient with hairy cell leukemia Unconjugated Liquid tissue culture supernatant 0.09% sodium azide 4 C Species Reactivity Tested species reactivity Published species reactivity Human Tested Applications Dilution * Flow Cytometry (Flow) 1:2 Immunocytochemistry (ICC) 1:10-1:100 Immunofluorescence (IF) 1:10-1:100 Immunohistochemistry (Paraffin) (IHC (P)) Product data sheet Rabbit, Rat, Non-human primate, Human, Mouse, Not Applicable, Rhesus monkey 1:100 Western Blot (WB) 1:1-1:100 Published Applications Immunohistochemistry (IHC) Miscellaneous PubMed (MISC) Immunohistochemistry (Paraffin) (IHC (P)) Immunocytochemistry (ICC) Flow Cytometry (Flow) See 58 publications below See 2 publications below See 5 publications below See 1 publications below See 1 publications below * Suggested working dilutions are given as a guide only. It is recommended that the user titrate the product for use in their own experiment using appropriate negative and positive controls. Product specific information MA targets CD31 in ICC/IF, FACS, WB and IHC (P) applications and shows reactivity with Human samples. The MA immunogen is membrane preparation of a spleen from a patient with hairy cell leukemia. Background/Target Information CD31 is a glycoprotein expressed on endothelial cells and in platelets. It is known to be involved in cell signaling and cell adhesion.

2 Product Images For CD31 Monoclonal Antibody (JC/70A) CD31 Antibody (MA ) in IF Immunofluorescent analysis of CD31 (green) showing staining in the cytoplasm and membrane of THP-1 cells (right) compared to a negative control without primary antibody (left). Formalin-fixed cells were permeabilized with 0.1% Triton X-100 in TBS for 5-10 minutes and blocked with 3% BSA-PBS for 30 minutes at room temperature. Cells were probed with a CD31 monoclonal antibody (Product # MA ) in 3% BSA-PBS at a dilution of 1:20 and incubated overnight at 4 C in a humidified chamber. Cells were washed with PBST and incubated with a DyLight-conjugated secondary antibody in PBS at room temperature in the dark. F-actin (red) was stained with a flourescent red phalloidin and nuclei (blue) were stained with Hoechst or DAPI. Images were taken at a magnification of 60x. CD31 Antibody (MA ) in IHC Formalin-fixed, paraffin-embedded human tonsil stained with CD31 antibody using peroxidase-conjugate and AEC chromogen. Note cell membrane staining of endothelial cells. CD31 Antibody (MA ) in WB Western blot analysis of CD31 was performed by loading 25 ug of THP-1 cell lysates onto an SDS polyacrylamide gel. Proteins were transferred to a PVDF membrane and blocked at 4 C overnight. The membrane was probed with a CD31 monoclonal antibody (Product # MA ) at a dilution of 1:10 overnight at 4 C, washed in TBST, and probed with an HRP-conjugated secondary antibody for 1 hr at room temperature in the dark. Chemiluminescent detection was performed using Pierce ECL Plus Western Blotting Substrate (Product # 32132). Results show a band at ~130 kda. CD31 Antibody (MA ) in Flow Flow cytometry analysis of CD31 in PBMC cells (green) compared to an isotype control (blue). Human blood was collected, combined with a hydrophilic polysaccharide, centrifuged, transferred to a conical tube and washed with PBS. 50 ul of cell solution was added to each tube at a dilution of 2x10^7 cells/ml, followed by the addition of 50 ul of isotype control and primary antibody (Product # MA ) at a dilution of 1:2. Cells were incubated for 30 min at 4 C and washed with a cell buffer, followed by incubation with a DyLight 488-conjugated secondary antibody for 30 min at 4 C in the dark. FACS analysis was performed using 400 ul of cell buffer.

3 PubMed References For CD31 Monoclonal Antibody (JC/70A) 58 Immunohistochemistry References Species / Dilution Summary MA was used in immunohistochemistry to analyze the affect of endothelial interleukin-21 receptor up-regulation in peripheral artery disease Not Applicable / 1:100 Rat / 1:30 Human / 1:70 Vascular medicine (London, England) (Apr 2016; 21: 99) "Endothelial interleukin-21 receptor up-regulation in peripheral artery disease." Author(s):Wang T,Cunningham A,Houston K,Sharma AM,Chen L,Dokun AO,Lye RJ,Spolski R,Leonard WJ,Annex BH PubMed Article URL:http://dx.doi.org/ / X MA was used in immunohistochemistry to study the effects of maternal injection with an anti-vegf antibody on early fetal development in a rat model The journal of maternal-fetal and neonatal medicine : the official journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians (Nov 2014; 27: 1744) "Effect of anti-vascular endothelial growth factor antibody during early fetal development in rats." Author(s):Kaygusuz I,Eser A,Inegol Gumus I,Kosus A,Yenidunya S,Namuslu M,Kafali H PubMed Article URL:http://dx.doi.org/ / MA was used in immunohistochemistry to perform a prospective clinical study in hypospadias patients to examine the potential relationship between preputial blood flow and microvessel density Journal of pediatric urology (Feb 2014; 10: 103) "The correlation between preputial blood flow and microvessel density in distal hypospadias: a prospective clinical study." Author(s):Ceyhan L,Cagri Savas M,Baspinar S,Duman L,Büyükyavuz BI PubMed Article URL:http://dx.doi.org/ /j.jpurol MA was used in immunohistochemistry to report on a case of left atrial cardiac myxoma with incidental atypical B-cell lymphoid proliferation Cardiovascular pathology : the official journal of the Society for Cardiovascular Pathology (May 2013; 22: e5) "Incidental Epstein-Barr virus associated atypical lymphoid proliferation arising in a left atrial myxoma: a case of long survival without any postsurgical treatment and review of the literature." Author(s):Bartoloni G,Pucci A,Giorlandino A,Berretta M,Mignosa C,Italia F,Carbone A,Canzonieri V PubMed Article URL:http://dx.doi.org/ /j.carpath MA was used in immunohistochemistry to report on a case of dural angioleiomyoma of the middle cranial fossa Brain tumor pathology (Apr 2013; 30: 117) "Dural angioleiomyoma of the middle cranial fossa: a case report and review of the literature." Author(s):Zhou Z,Yu M,Yang S,Zhou J,Sun R,Yang G PubMed Article URL:http://dx.doi.org/ /s z MA was used in immunohistochemistry to study the correlation between 3-dimensinal Doppler ultrasound indicies and histopathology in uterine fibroids Ultrasound in obstetrics and gynecology : the official journal of the International Society of Ultrasound in Obstetrics and Gynecology (Dec 2012; 40: 714) "Does three-dimensional power Doppler ultrasound predict histopathological findings of uterine fibroids? A preliminary study." Author(s):Minsart AF,Ntoutoume Sima F,Vandenhoute K,Jani J,Van Pachterbeke C PubMed Article URL:http://dx.doi.org/ /uog MA was used in immunohistochemistry to study the clinicomorphology of vesicular and bullous lesions in Kaposi sarcoma Diagnostic pathology (Aug 2012; 7: null) "Histopathological analysis of vesicular and bullous lesions in Kaposi sarcoma." Author(s):Kandemir NO,Barut F,Gün BD,Tekin NS,Keser SH,Ozdamar SO PubMed Article URL:http://dx.doi.org/ /

4 MA was used in immunohistochemistry to report on three cases of epithelioid angiosarcoma arising in schwannoma Human / 1:30 Rabbit / 1:500 Non-human primate / 1:100 Human / 1:100 Mouse / 1:100 Pathology international (Jul 2012; 62: 500) "Epithelioid angiosarcoma arising in schwannoma: report of three Chinese cases with review of the literature." Author(s):Li C,Chen Y,Zhang H,Zheng X,Wang J PubMed Article URL:http://dx.doi.org/ /j x MA was used in immunohistochemistry to study the mechanism by which MFG-E8/lactadherin promotes the tumorigenesis of mammary epithelial cells Oncogene (Mar 2012; 31: 1521) "MFG-E8/lactadherin regulates cyclins D1/D3 expression and enhances the tumorigenic potential of mammary epithelial cells." Author(s):Carrascosa C,Obula RG,Missiaglia E,Lehr HA,Delorenzi M,Frattini M,Rüegg C,Mariotti A PubMed Article URL:http://dx.doi.org/ /onc MA was used in immunohistochemistry to study the efficacy of anti-angiogenic therapy in rabbit VX2 tumors using three-dimensional computed tomographic angiography Academic radiology (Mar 2012; 19: 358) "CTA combined with CT perfusion for assessing the efficacy of anti-angiogenic therapy in rabbit VX2 tumors." Author(s):Wang H,Zheng LF,Feng Y,Xie XQ,Yang XM,Zhang GX PubMed Article URL:http://dx.doi.org/ /j.acra MA was used in immunohistochemistry to study the molecualr basis of lymphatic differentiation in classic Kaposi's sarcoma Pathology oncology research : POR (Dec 2011; 17: 843) "Lymphatic differentiation in classic Kaposi's sarcoma: patterns of D2-40 immunoexpression in the course of tumor progression." Author(s):Kandemir NO,Barut F,Gun BD,Keser SH,Karadayi N,Gun M,Ozdamar SO PubMed Article URL:http://dx.doi.org/ /s MA was used in immunohistochemistry to study the effect of donor age on the recellularization of decellularized kidney sections Tissue engineering. Part A (Dec 2011; 17: 2891) "Renal tissue engineering with decellularized rhesus monkey kidneys: age-related differences." Author(s):Nakayama KH,Batchelder CA,Lee CI,Tarantal AF PubMed Article URL:http://dx.doi.org/ /ten.TEA MA was used in immunohistochemistry to study the expression of vascular growth factors and hypoxia-inducible factor in human gingival tissue of the oral cavity Okajimas folia anatomica Japonica (Aug 2011; 88: 75) "Analysis of vascular distribution and growth factors in human gingival tissue associated with periodontal probing depth." Author(s):Noguchi K,Miwa Y,Sunohara M,Sato I MA was used in immunohistochemistry to investigate the function of NFATc3 in angiogenesis stimulated by secreted frizzled-related protein 2 SFRP2 PloS one (Jun 2011; 6: null) "The role of calcineurin/nfat in SFRP2 induced angiogenesis--a rationale for breast cancer treatment with the calcineurin inhibitor tacrolimus." Author(s):Siamakpour-Reihani S,Caster J,Bandhu Nepal D,Courtwright A,Hilliard E,Usary J,Ketelsen D,Darr D,Shen XJ, Patterson C,Klauber-Demore N PubMed Article URL:http://dx.doi.org/ /journal.pone MA was used in immunohistochemistry to study the levels of decorin and fibromodulin in postburn hypertrophic scar tissue Wound repair and regeneration : official publication of the Wound Healing Society [and] the European Tissue Repair Society (May 2011; 19: 368) "Small leucine-rich proteoglycans, decorin and fibromodulin, are reduced in postburn hypertrophic scar." Author(s):Honardoust D,Varkey M,Hori K,Ding J,Shankowsky HA,Tredget EE PubMed Article URL:http://dx.doi.org/ /j X x

5 MA was used in immunohistochemistry to study the molecular effects of a mtor inhibitor in bladder cancer cells Human / 1:40 Human / 1:100 Human / 1:30 Clinical cancer research : an official journal of the American Association for Cancer Research (May 2011; 17: 2863) "Effects of mtor inhibitor everolimus (RAD001) on bladder cancer cells." Author(s):Chiong E,Lee IL,Dadbin A,Sabichi AL,Harris L,Urbauer D,McConkey DJ,Dickstein RJ,Cheng T,Grossman HB PubMed Article URL:http://dx.doi.org/ / CCR MA was used in immunohistochemistry to study the molecular targets of sorafenib in a xenograft model of renal cell carcinoma British journal of cancer (Mar 2011; 104: 941) "Inhibition of angiogenic and non-angiogenic targets by sorafenib in renal cell carcinoma (RCC) in a RCC xenograft model." Author(s):Yuen JS,Sim MY,Siml HG,Chong TW,Lau WK,Cheng CW,Huynh H PubMed Article URL:http://dx.doi.org/ /bjc MA was used in immunohistochemistry to study the protein levels of COX-2 and survivin in superficial urothelial carcinoma and their correlation with microvessel density The Journal of international medical research (Feb 2011; 38: 1689) "Cyclooxygenase-2 and survivin in superficial urothelial carcinoma of the bladder and correlation with intratumoural microvessel density." Author(s):Yildirim U,Erdem H,Kayikci A,Sahin AF,Uzunlar AK,Albayrak A PubMed Article URL:http://dx.doi.org/ / MA was used in immunohistochemistry to investigate the prognostic significance of inducible cyclooxgenase-2 activation in breast cancer BMC cancer (Nov 2010; 10: null) "COX-2 activation is associated with Akt phosphorylation and poor survival in ER-negative, HER2-positive breast cancer." Author(s):Glynn SA,Prueitt RL,Ridnour LA,Boersma BJ,Dorsey TM,Wink DA,Goodman JE,Yfantis HG,Lee DH,Ambs S PubMed Article URL:http://dx.doi.org/ / MA was used in immunohistochemistry to investigate the efficacy of micropapillary component for adenocarcinoma prognosis Pathology (Sep 2010; 42: 560) "The presence of a micropapillary component predicts aggressive behaviour in early and advanced gastric adenocarcinomas." Author(s):Lee JH,Kim JH,Choi JW,Kim YS PubMed Article URL:http://dx.doi.org/ / MA was used in immunohistochemistry to study the mechanisms by which the interaction of adipose tissue progenitor cells with endothelial cells promotes vasculogenesis Tissue engineering. Part A (Sep 2010; 16: 2953) "Adipose tissue progenitor cells directly interact with endothelial cells to induce vascular network formation." Author(s):Merfeld-Clauss S,Gollahalli N,March KL,Traktuev DO PubMed Article URL:http://dx.doi.org/ /ten.tea MA was used in immunohistochemistry to study the histopathological diagnosis of cutaneous vascular sarcomas Romanian journal of morphology and embryology = Revue roumaine de morphologie et embryologie (Mar 2010; 51: 105) "Histopathological diagnosis of cutaneous vascular sarcomas." Author(s):Costache M,Ene AM,Simionescu O,Sajin M MA was used in immunohistochemistry to study the effect of a MEK inhibitor on the antitumor activity of rapamycin in human hepatocellular carcinoma xenografts Cancer (Mar 2010; 116: 1315) "AZD6244 (ARRY ) enhances the antitumor activity of rapamycin in mouse models of human hepatocellular carcinoma." Author(s):Huynh H PubMed Article URL:http://dx.doi.org/ /cncr.24863

6 MA was used in immunohistochemistry to study the progression of fibroatheromas in the general population using autopsied coronary arteries Non-human primate / Not Cited Human / 1:40 Rhesus monkey / 1:100 Korean circulation journal (Oct 2009; 39: 399) "Progression and observational frequency of atheromatous plaques in autopsied coronary arteries." Author(s):Lee WS,Kim SW,Ryu WS PubMed Article URL:http://dx.doi.org/ /kcj MA was used in immunohistochemistry to study the effect of a MAP/ERK kinase inhibitor on the effectiveness of sorafenib in mouse gastric cancer models Molecular cancer therapeutics (Sep 2009; 8: 2537) "AZD6244 (ARRY ) enhances the therapeutic efficacy of sorafenib in mouse models of gastric cancer." Author(s):Yang S,Ngo VC,Lew GB,Chong LW,Lee SS,Ong WJ,Lam WL,Thng CH,Koong HN,Ong HS,Chung A,Chow P,Lee J, Soo KC,Huynh H PubMed Article URL:http://dx.doi.org/ / MCT MA was used in immunohistochemistry to develop a novel method for the in-vivo imaging of retinal nerve fiber layer vasculature BMC ophthalmology (Aug 2009; 9: null) "In-vivo imaging of retinal nerve fiber layer vasculature: imaging histology comparison." Author(s):Scoles D,Gray DC,Hunter JJ,Wolfe R,Gee BP,Geng Y,Masella BD,Libby RT,Russell S,Williams DR,Merigan WH PubMed Article URL:http://dx.doi.org/ / MA was used in immunohistochemistry to study the expression of Nogo-B in coronary arteries during the progression of atherosclerosis Journal of Korean medical science (Aug 2009; 24: 596) "Atherosclerotic progression attenuates the expression of Nogo-B in autopsied coronary artery: pathology and virtual histology intravascular ultrasound analysis." Author(s):Lee WS,Kim SW,Hong SA,Lee TJ,Park ES,Kim HJ,Lee KJ,Kim TH,Kim CJ,Ryu WS PubMed Article URL:http://dx.doi.org/ /jkms MA was used in immunohistochemistry to study the effect of the mtor inhibitor everolimus on tumour growth in xenograft models of human hepatocellular carcinoma Journal of cellular and molecular medicine (Jul 2009; 13: 1371) "RAD001 (everolimus) inhibits tumour growth in xenograft models of human hepatocellular carcinoma." Author(s):Huynh H,Chow KH,Soo KC,Toh HC,Choo SP,Foo KF,Poon D,Ngo VC,Tran E PubMed Article URL:http://dx.doi.org/ /j x MA was used in immunohistochemistry to compare the CD31 and CD105 endothelial areas in colorectal carcinomas by computer-assisted morphometrical analysis Romanian journal of morphology and embryology = Revue roumaine de morphologie et embryologie (May 2009; 50: 239) "The differences between the endothelial area marked with CD31 and CD105 in colorectal carcinomas by computerassisted morphometrical analysis." Author(s):Jung I,Gurzu S,Raica M,Cîmpean AM,Szentirmay Z MA was used in immunohistochemistry to report on a case of pediatric hepatic hemangiosarcoma in a rhesus macaque Journal of medical primatology (Apr 2009; 38: 121) "Pediatric hepatic hemangiosarcoma in a rhesus macaque (Macaca mulatta)." Author(s):Mejía AF,Gierbolini L,Jacob B,Westmoreland SV PubMed Article URL:http://dx.doi.org/ /j x MA was used in immunohistochemistry to compare tumor microenvironments between African-American and European-American breast cancer patients PloS one (Feb 2009; 4: null) "Differences in the tumor microenvironment between African-American and European-American breast cancer patients." Author(s):Martin DN,Boersma BJ,Yi M,Reimers M,Howe TM,Yfantis HG,Tsai YC,Williams EH,Lee DH,Stephens RM, Weissman AM,Ambs S PubMed Article URL:http://dx.doi.org/ /journal.pone

7 MA was used in immunohistochemistry to investigate the expression of mammalian actin regulatory protein Ena in colorectal lesions Mouse / Not Cited Human / 1:40 Romanian journal of morphology and embryology = Revue roumaine de morphologie et embryologie (Sep 2008; 49: 345) "The expression of cytoskeleton regulatory protein Mena in colorectal lesions." Author(s):Gurzu S,Jung I,Prantner I,Ember I,Pávai Z,Mezei T MA was used in immunohistochemistry to examine the role of cyclooxygenase-2 expression in the development and progression of gastric carcinoma Pathology, research and practice (Jul 2008; 204: 527) "Cyclooxygenase-2 expression and its association with angiogenesis, Helicobacter pylori, and clinicopathologic characteristics of gastric carcinoma." Author(s):Yamac D,Ayyildiz T,Cokun U,Akyürek N,Dursun A,Seckin S,Koybasioglu F PubMed Article URL:http://dx.doi.org/ /j.prp MA was used in immunohistochemistry to study the prognostic value of angiogenesis in colorectal carcinomas with and without lymph node metastases Romanian journal of morphology and embryology = Revue roumaine de morphologie et embryologie (Jun 2008; 49: 149) "The angiogenesis in colorectal carcinomas with and without lymph node metastases." Author(s):Gurzu S,Jung J,Azamfirei L,Mezei T,Cîmpean AM,Szentirmay Z MA was used in immunohistochemistry to investigate the prognostic significance of lymphatic vascular density in oral carcinoma World journal of surgical oncology (Dec 2007; 5: null) "How useful is the assessment of lymphatic vascular density in oral carcinoma prognosis?" Author(s):Longatto Filho A,Oliveira TG,Pinheiro C,de Carvalho MB,Curioni OA,Mercante AM,Schmitt FC,Gattás GJ PubMed Article URL:http://dx.doi.org/ / MA was used in immunohistochemistry to compare the aspects of angiogenesis between anal canal and colorectal carcinomas Romanian journal of morphology and embryology = Revue roumaine de morphologie et embryologie (Dec 2007; 48: 349) "The aspects of angiogenesis in anal canal carcinomas compared with that in colorectal carcinomas." Author(s):Gurzu S,Jung J,Azamfirei L,Mezei T,Cîmpean AM MA was used in immunohistochemistry to study the effect of bevacizumab and rapamycin on tumor growth in a peritoneal ovarian cancer model Molecular cancer therapeutics (Nov 2007; 6: 2959) "Bevacizumab and rapamycin inhibit tumor growth in peritoneal model of human ovarian cancer." Author(s):Huynh H,Teo CC,Soo KC PubMed Article URL:http://dx.doi.org/ / MCT MA was used in immunohistochemistry to report on a case of epithelioid angiosarcoma arising in a deep-seated plexiform schwannoma Human pathology (Jul 2007; 38: 1096) "Epithelioid angiosarcoma arising in a deep-seated plexiform schwannoma: a case report and literature review." Author(s):Lee FY,Wen MC,Wang J PubMed Article URL:http://dx.doi.org/ /j.humpath MA was used in immunohistochemistry to report on a case of myointimoma of the glans penis Pathology international (Mar 2007; 57: 158) "Myointimoma of the glans penis." Author(s):Vardar E,Gunlusoy B,Arslan M,Kececi S PubMed Article URL:http://dx.doi.org/ /j x MA was used in immunohistochemistry to study the relationship between microvessel density, VEGF expression, and tumor-associated macrophages in breast tumors Journal of experimental and clinical cancer research : CR (Sep 2006; 25: 365) "Microvessel density, VEGF expression, and tumor-associated macrophages in breast tumors: correlations with prognostic parameters." Author(s):Bolat F,Kayaselcuk F,Nursal TZ,Yagmurdur MC,Bal N,Demirhan B

8 MA was used in immunohistochemistry to study the role of a novel protease complex of DPP4 and seprase in the migration and invasion of human endothelial cells Human / 1:20-1:40 Human / 1:100 Human / 1:30 Human / 1:25 Cancer research (May 2006; 66: 4652) "The protease complex consisting of dipeptidyl peptidase IV and seprase plays a role in the migration and invasion of human endothelial cells in collagenous matrices." Author(s):Ghersi G,Zhao Q,Salamone M,Yeh Y,Zucker S,Chen WT PubMed Article URL:http://dx.doi.org/ / CAN MA was used in immunohistochemistry to study the effects of angiogenic factor overexpression by human and rodent cholangiocytes in polycystic liver diseases Hepatology (Baltimore, Md.) (May 2006; 43: 1001) "Effects of angiogenic factor overexpression by human and rodent cholangiocytes in polycystic liver diseases." Author(s):Fabris L,Cadamuro M,Fiorotto R,Roskams T,Spirlì C,Melero S,Sonzogni A,Joplin RE,Okolicsanyi L,Strazzabosco M PubMed Article URL:http://dx.doi.org/ /hep MA was used in immunohistochemistry to study the correlation between MMP and VEGF expression and oral tongue cancer invasiveness Journal of surgical oncology (Mar 2006; 93: 330) "Correlations of oral tongue cancer invasion with matrix metalloproteinases (MMPs) and vascular endothelial growth factor (VEGF) expression." Author(s):Kim SH,Cho NH,Kim K,Lee JS,Koo BS,Kim JH,Chang JH,Choi EC PubMed Article URL:http://dx.doi.org/ /jso MA was used in immunohistochemistry to report a clinical case of cystic lymphangioma in the right adrenal gland Pathology oncology research : POR (Jan 2006; 11: 242) "Cystic lymphangioma of the right adrenal gland." Author(s):Ates LE,Kapran Y,Erbil Y,Barbaros U,Dizdaroglu F PubMed Article URL:http://dx.doi.org/PAOR MA was used in immunohistochemistry to report on a case of ectopic cervical anaplastic ependymoma Pathology international (Dec 2005; 55: 781) "Ectopic cervical anaplastic ependymoma." Author(s):Wang Z,Huang G,Yan P,Liang R,Wang J,Yan Q,Zhang J,Cheng H,Hu P,Ma MJ PubMed Article URL:http://dx.doi.org/ /j x MA was used in immunohistochemistry to study the effect of the methotrexate treatment on the expression of ICAM- 3, Ki-67, PCNA and CD31 in psoriatic lesions Archives of dermatological research (Dec 2005; 297: 249) "The changes in expression of ICAM-3, Ki-67, PCNA, and CD31 in psoriatic lesions before and after methotrexate treatment." Author(s):Yazici AC,Tursen U,Apa DD,Ikizoglu G,Api H,Baz K,Tasdelen B PubMed Article URL:http://dx.doi.org/ /s MA was used in immunohistochemistry to study the expression of Prox-1 and CD 31 in normal tissue, lesions, and tumors Pathology, research and practice (Nov 2005; 201: 771) "Differential Prox-1 and CD 31 expression in mucousae, cutaneous and soft tissue vascular lesions and tumors." Author(s):Reis RM,Reis-Filho JS,Longatto Filho A,Tomarev S,Silva P,Lopes JM PubMed Article URL:http://dx.doi.org/ /j.prp MA was used in immunohistochemistry to report on a case of interdigitating dendritic cell tumor with breast and cervical lymph-node involvement Virchows Archiv : an international journal of pathology (May 2005; 446: 546) "Interdigitating dendritic cell tumor with breast and cervical lymph-node involvement: a case report and review of the literature." Author(s):Uluolu O,Akyürek N,Uner A,Cokun U,Ozdemir A,Gökçora N PubMed Article URL:http://dx.doi.org/ /s

9 MA was used in immunohistochemistry to study oseoclast-like multi-nucleated giant cells in Langerhans cell histiocytosis lesions Mouse / Not Cited Human / 1:80 Human / 1:100 Human / 1:100 The Journal of experimental medicine (Mar 2005; 201: 687) "Presence of osteoclast-like multinucleated giant cells in the bone and nonostotic lesions of Langerhans cell histiocytosis." Author(s):da Costa CE,Annels NE,Faaij CM,Forsyth RG,Hogendoorn PC,Egeler RM PubMed Article URL:http://dx.doi.org/ /jem MA was used in immunohistochemistry to study the role of apoptosis in vascular lumen formation and branching in human placental vasculogenesis Biology of reproduction (Mar 2005; 72: 727) "Apoptosis contributes to vascular lumen formation and vascular branching in human placental vasculogenesis." Author(s):Tertemiz F,Kayisli UA,Arici A,Demir R PubMed Article URL:http://dx.doi.org/ /biolreprod MA was used in immunohistochemistry to investigate the process of The Journal of experimental medicine (Oct 2004; 200: 917) "Varicella-zoster virus transfer to skin by T Cells and modulation of viral replication by epidermal cell interferonalpha." Author(s):Ku CC,Zerboni L,Ito H,Graham BS,Wallace M,Arvin AM PubMed Article URL:http://dx.doi.org/ /jem MA was used in immunohistochemistry to report on a case of Mazabraud's syndrome Pathology oncology research : POR (Jun 2004; 10: 121) "Mazabraud's syndrome: intramuscular myxoma associated with fibrous dysplasia." Author(s):Kabukcuoglu F,Kabukcuoglu Y,Yilmaz B,Erdem Y,Evren I PubMed Article URL:http://dx.doi.org/PAOR MA was used in immunohistochemistry to study differences in cytokeratin levels between villous and extravillous trophoblasts using confocal laser scanning microscopy Microscopy research and technique (May 2004; 64: 43) "Confocal laser scanning microscope study of cytokeratin immunofluorescence differences between villous and extravillous trophoblast: cytokeratin downregulation in pre-eclampsia." Author(s):Ockleford CD,Smith RK,Byrne S,Sanders R,Bosio P PubMed Article URL:http://dx.doi.org/ /jemt MA was used in immunohistochemistry to study the cellular proliferative activity of restenotic lesions American journal of kidney diseases : the official journal of the National Kidney Foundation (Jan 2004; 43: 74) "Highly increased cell proliferation activity in the restenotic hemodialysis vascular access after percutaneous transluminal angioplasty: implication in prevention of restenosis." Author(s):Chang CJ,Ko PJ,Hsu LA,Ko YS,Ko YL,Chen CF,Huang CC,Hsu TS,Lee YS,Pang JH MA was used in immunohistochemistry to study whether mesoappendix infiltration predicts a worse prognosis in incidental neuroendocrine tumors of the appendix American journal of clinical pathology (Nov 2003; 120: 706) "Does mesoappendix infiltration predict a worse prognosis in incidental neuroendocrine tumors of the appendix? A clinicopathologic and immunohistochemical study of 15 cases." Author(s):Rossi G,Valli R,Bertolini F,Sighinolfi P,Losi L,Cavazza A,Rivasi F,Luppi G PubMed Article URL:http://dx.doi.org/ /199V-D990-LVHP-TQUM MA was used in immunohistochemistry to study the correlation of allograft inflammatory factor-1 expression with cardiac rejection and development of cardiac allograft vasculopathy Circulation (Oct 2002; 106: 2218) "Allograft inflammatory factor-1 expression correlates with cardiac rejection and development of cardiac allograft vasculopathy." Author(s):Autieri MV,Kelemen S,Thomas BA,Feller ED,Goldman BI,Eisen HJ

10 MA was used in immunohistochemistry to study the role of NK4 in supressing angiogenesis and tumor progression in pancreatic cancer Mouse / 1:50 Clinical cancer research : an official journal of the American Association for Cancer Research (Oct 2002; 8: 3243) "Tumor suppression through angiogenesis inhibition by SUIT-2 pancreatic cancer cells genetically engineered to secrete NK4." Author(s):Saimura M,Nagai E,Mizumoto K,Maehara N,Minamishima YA,Katano M,Matsumoto K,Nakamura T,Tanaka M MA was used in immunohistochemistry to study the role of angiogenic and anti-angigenic factors in papillary thyroid carcinoma 2 Miscellaneous PubMed References Species / Dilution Clinical cancer research : an official journal of the American Association for Cancer Research (May 2002; 8: 1125) "Inhibition of infiltration and angiogenesis by thrombospondin-1 in papillary thyroid carcinoma." Author(s):Tanaka K,Sonoo H,Kurebayashi J,Nomura T,Ohkubo S,Yamamoto Y,Yamamoto S Summary MA was used in immunohistochemistry to assess the prognostic value of FGF18 expression in serous and mucinous ovarian tumors Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine (Mar 2016; 37: 3173) "FGF18 as a potential biomarker in serous and mucinous ovarian tumors." Author(s):El-Gendi S,Abdelzaher E,Mostafa MF,Sheasha GA PubMed Article URL:http://dx.doi.org/ /s MA was used in flow cytometry to compare mesenchymal stem cells versus chitosan in wound healing Rat / 1: Immunohistochemistry (Paraffin) References Species / Dilution PloS one (Sep 2015; 10: null) "The Effect of Mesenchymal Stem Cells and Chitosan Gel on Full Thickness Skin Wound Healing in Albino Rats: Histological, Immunohistochemical and Fluorescent Study." Author(s):El Sadik AO,El Ghamrawy TA,Abd El-Galil TI PubMed Article URL:http://dx.doi.org/ /journal.pone Summary MA was used in immunohistochemistry - paraffin section to describe methods to detect restrictive amino acids and measure differential ribosome codon reading. Human / 1:300 Not Applicable / Not Cited Human / 1:200 Nature (Feb 2016; 530: 490) "Tumour-specific proline vulnerability uncovered by differential ribosome codon reading." Author(s):Loayza-Puch F,Rooijers K,Buil LC,Zijlstra J,Oude Vrielink JF,Lopes R,Ugalde AP,van Breugel P,Hofland I, Wesseling J,van Tellingen O,Bex A,Agami R PubMed Article URL:http://dx.doi.org/ /nature16982 MA was used in immunohistochemistry - paraffin section to study the increased expression of TEM7 and VEGF-C to promote angiogenesis of gliobastomas by a gain-of-function GLI1 transcription factor, TGLI1 Oncotarget (Sep 2015; 6: 22653) "The gain-of-function GLI1 transcription factor TGLI1 enhances expression of VEGF-C and TEM7 to promote glioblastoma angiogenesis." Author(s):Carpenter RL,Paw I,Zhu H,Sirkisoon S,Xing F,Watabe K,Debinski W,Lo HW PubMed Article URL:http://dx.doi.org/ /oncotarget.4248 MA was used in immunohistochemistry - paraffin section to study the clinical significance of aldehyde dehydrogenase 1 expression in the invasive front of nasopharyngeal carcinoma Virchows Archiv : an international journal of pathology (Jan 2014; 464: 35) "Cancer stem cell characteristics, ALDH1 expression in the invasive front of nasopharyngeal carcinoma." Author(s):Luo WR,Yao KT PubMed Article URL:http://dx.doi.org/ /s z

11 MA was used in immunohistochemistry - paraffin section to evaluate the prognostic value of mast cells numbers and peritumoral microvessel density in prostatic adenocarcinomas Human / 1:40 Medicinski glasnik : official publication of the Medical Association of Zenica-Doboj Canton, Bosnia and Herzegovina (Aug 2013; 10: 293) "Mast cells numbers and peritumoral microvessel density of the prostatic adenocarcinomas and correlation with prognostic parameters." Author(s):Erdem H,Kayikci MA,Oktay M,Uzunlar AK,Tekin A,Sener E,Ankarali H,Gursan N,ahiner C,Kadolu N MA was used in immunohistochemistry - paraffin section to investigate the mechanisms that lead to demyelination and neurodegeneration Not Applicable / 1:250 1 Immunocytochemistry References Species / Dilution 1 Flow Cytometry References Species / Dilution Brain : a journal of neurology (Jun 2013; 136: 1799) "Disease-specific molecular events in cortical multiple sclerosis lesions." Author(s):Fischer MT,Wimmer I,Höftberger R,Gerlach S,Haider L,Zrzavy T,Hametner S,Mahad D,Binder CJ,Krumbholz M, Bauer J,Bradl M,Lassmann H PubMed Article URL:http://dx.doi.org/ /brain/awt110 Summary MA was used in immunocytochemistry to investigate the effect of fibronectin on macrophage differentiation of HL60 cells induced by phorbol 12-myristate 13-acetate International journal of hematology (Mar 2009; 89: 167) "Fibronectin promotes the phorbol 12-myristate 13-acetate-induced macrophage differentiation in myeloid leukemia cells." Author(s):Esendagli G,Canpinar H,Yilmaz G,Kaymaz FF,Kansu E,Guc D PubMed Article URL:http://dx.doi.org/ /s Summary MA was used in flow cytometry to compare human saphenous vein endothelial cells with human umbilical vein endothelial cells Not Applicable / Not Cited Atherosclerosis (Apr 2004; 173: 171) "Phenotypic and functional differences between human saphenous vein (HSVEC) and umbilical vein (HUVEC) endothelial cells." Author(s):Tan PH,Chan C,Xue SA,Dong R,Ananthesayanan B,Manunta M,Kerouedan C,Cheshire NJ,Wolfe JH,Haskard DO, Taylor KM,George AJ PubMed Article URL:http://dx.doi.org/ /j.atherosclerosis

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