SPECT/CT Imaging of the Sentinel Lymph Node
|
|
- Duane Crawford
- 6 years ago
- Views:
Transcription
1 IAEA Regional Training Course on Hybrid Imaging SPECT/CT Imaging of the Sentinel Lymph Node Giuliano Mariani Regional Center of Nuclear Medicine, University of Pisa Medical School, Pisa, Italy Vilnius, August 27 31, 2012
2 (in press)
3 The Sentinel Lymph Node Concept in Oncologic Surgery Lymphatic dissemination of solid tumors generally occurs in a sequential fashion. Tumor status of regional lymph nodes is the most important single prognostic factor for a variety of solid tumors. Clinical evaluation and preoperative imaging are generally ineffective in ascertaining tumor status of regional lymph nodes in patients with early cancers. In traditional oncologic surgery, tumor status of a certain lymphatic basin is assessed by complete lymph node dissection and histologic analysis of all resected lymph nodes.
4 The Sentinel Lymph Node Concept in Oncologic Surgery Complete lymph node dissection is burdened with a high rate of short- and long-term complcations. In the majority of patients with early cancers the lymphatic basin of interest is free from metastasis, therefore complete lymph node dissection turns out to be have been performed unnecessarily. Histologic analysis of all resected lymph nodes (up to 20 per basin) is a time-consuming procedure involving a non-negligible risk of underestimating metastatic involvement (only 2-3 sections evaluated per lymph node).
5 The Sentinel Lymph Node Concept in Oncologic Surgery According to orderly progression of lymphatic metastasis, if the first lymph node encountered by lymph draining from the tumor (the sentinel lymph node) is free from metastasis, then it is highly unlikely that subsequent nodes along the same pathway contain metastasis. Therefore, complete lymph node dissection can be replaced by the less aggressive selective resection of the sentinel lymph node(s) only. Concentrating detailed histologic analysis on few lymph nodes increases the chance of detecting metastasis, even as isolated tumor cells.
6 The Sentinel Lymph Node Concept in Oncologic Surgery A certain rate of false-negative results occur in sentinel lymph node biopsy False-negative results are defined as the presence of metastasis in non-sentinel lymph nodes when the sentinel node does not contain metastasis. The above definition implies complete lymph node dissection at the time of primary surgery. Alternatively, false-negative results are defined as the appearance of metastasis during follow-up in a lymphatic basin that had been classified as negative on the basis of sentinel lymph node biopsy.
7 The Sentinel Lymph Node Concept in Oncologic Surgery Despite a certain rate of false-negative results, sentinel lymph node biopsy has proven to be a safe and accurate method of lymphatic staging, mainly in patients with early breast cancer or with melanoma. The most recent TNM classification includes specific notation for sentinel lymph node status. Sentinel lymph node biopsy is now the accepted standard of care for patients with early breast cancer or with melanoma. All other applications are to be considered part of clinical investigation protocols.
8 Intents of Sentinel Lymph Node Biopsy For some tumors (such as breast cancer) sentinel lymph node biopsy is performed with purely stagingprognostic purposes. When metastasis is found in the sentinel lymph node, completion lymphadenectomy of the lymphatic basin is performed primarily for more accurate staging. Whereas, for other tumors (such as melanoma) completion lymphadenectomy after finding a metastatic sentinel lymph node is performed with therapeutic purposes, as it increases the chance of achieving better local control of the disease.
9 Radioguided Sentinel Lymph Node Biopsy Radioguidance is the most accurate method for performing sentinel lymph node biopsy (combined or not with visual blue-dye guidance). Lymphoscintigraphy with a radiocolloid agent injected interstitially at the site of the primary tumor is an integral component of radioguided sentinel lymph node biopsy. Uptake of the radiocolloid reflects a physiologic function of lymph nodes and in no way indicates the presence of metastatic tumor cells. The presence of metastasis in sentinel node(s) is ascertained by histologic analysis (H&E staining, immunohistochemistry, molecular analysis).
10 Radioguided Sentinel Lymph Node Biopsy Intra-operative counting with the hand-held gamma probe is the ultimate guidance for sentinel lymph node biopsy. Nevertheless, preoperative lymphoscintigraphy is crucial for correctly addressing the surgeon to the most likely location of sentinel lymph node(s). This is especially important for patterns of lymphatic drainage outside the expected basins, or for sentinel nodes in unusual locations. Dynamic acquisition is more important for some tumors (such as melanoma) rather than for other tumors (such as breast cancer).
11 OE Nieweg, 2012
12 OE Nieweg, 2012
13 OE Nieweg, 2012
14 OE Nieweg, 2012
15
16 Less Appropriate Definitions of the Sentinel Lymph Node Lymph node closest to the primary lesion. First lymph node depicted on the lymphoscintigraphy images. Lymph node with the highest count rate. Any radioactive lymph node. Lymph node with a count rate that is a certain factor higher than the background or compared to nonsentinel nodes. Lymph node with a count rate that exceeds a certain fraction of the hottest node. Blue lymph node.
17 Modalities for Localizing Anatomically the Sentinel Node on Lymphoscintigraphy Planar imaging without reference landmarks. Planar imaging with contour of the body by moving a radioactive point source. Planar imaging with transmission scan from a flood source beneath the patient s body. SPECT. SPECT/CT.
18
19
20
21
22
23
24
25
26
27 Breast Cancer
28 Breast Cancer
29 Breast Cancer
30 Breast Cancer
31 Breast Cancer
32 Breast Cancer
33 Melanoma
34 Melanoma
35 Melanoma
36 Melanoma
37 Melanoma in head and neck
38 Melanoma in head and neck
39 Penile cancer
40 Penile cancer
41 Penile cancer
42 Head and neck cancer
43 Head and neck cancer
44 Head and neck cancer
45 Head and neck cancer
46 Cervical cancer
47 Endometrial cancer
48 Vulvar cancer
49 Prostate cancer
50 Prostate cancer
51 Testicular cancer
52 Testicular cancer
53 Renal cancer
54 General Indications for SPECT/CT in Sentinel Lymph Node Biopsy In cases without visualization or with poor visualization at planar imaging. Due to the correction for tissue attenuation, SPECT/CT is usually more sensitive than planar imaging, and may be particularly useful in obese patients. Localization of SLNs in areas with complex anatomy and a high number of lymph nodes, such as the head and neck, or in cases with unexpected lymphatic drainage (e.g., between the pectoral muscles, internal mammary chain, level II or III of the axilla, or in the vicinity of the scapula) at planar imaging. Anatomical localization and detection of additional SLNs in areas of deep lymphatic drainage such as the pelvis, abdomen, or mediastinum.
55 Freehand SPECT imaging technology used in CSS300 during surgery Data with tracked non-imaging probe Non-uniform / non-symmetric set <180 covered Center depends on scan < 40 thousand events
56 Accessories of CSS300 Gamma probe with sterile tracking target Sterile patient target
57 Spatial localization system of CSS Handle (can be covered to be used sterile) 2. Optical camera 3. Infrared localization system 4. Non-sterile Handle 4
58 CSS300 for freehand SPECT Imaging & Navigation by SurgicEye s CSS300 freehand SPECT imaging and navigation device Gamma Detection using conventional gamma probe
59
60
61
62
The Concept of GOSTT
IAEA Regional Training Course on Sentinel Lymph Node Mapping and Radioguided Surgery The Concept of GOSTT Giuliano Mariani Regional Center of Nuclear Medicine, University of Pisa Medical School, Pisa,
More informationThe GOSTT concept. (radio)guided intraoperative Scintigraphic Tumor Targeting. Emmanuel Deshayes. GOSTT = Radioguided Surgery
IAEA WorkShop, November 2017 Emmanuel Deshayes With the kind help of Pr Francesco Giammarile The GOSTT concept GOSTT = Radioguided Surgery (radio)guided intraoperative Scintigraphic Tumor Targeting 1 Radioguided
More informationGOSTT General concept
GOSTT General concept Francesco GIAMMARILE «Aut tace aut loquere meliora silentio» Presentation Outline Introduction: GOSTT and radioguided surgery The Sentinel Node Concept Latest technological knowledge
More informationRadionuclide detection of sentinel lymph node
Radionuclide detection of sentinel lymph node Sophia I. Koukouraki Assoc. Professor Department of Nuclear Medicine Medicine School, University of Crete 1 BACKGROUND The prognosis of malignant disease is
More informationSentinel Node Localisation of Melanoma
Sentinel Node Localisation of Melanoma V Bongers, Diakonessenhuis, Utrecht 1. Introduction A melanoma is mostly a malignancy of the skin. The sentinel lymph node (SLN) concept of sequential progression
More information«Aut tace aut loquere meliora silentio» Francesco GIAMMARILE
«Aut tace aut loquere meliora silentio» Francesco GIAMMARILE Presentation Outline Introduction: the GOSTT Concept The EANM Guideline in Melanoma Future trends and concluding remarks I sort of thought your
More informationTechnical Considerations. Imaging Considerations
354 CUTANEOUS MALIGNANCY OF THE HEAD AND NECK desmoplastic melanomas are characterized by a uniform desmoplasia that is prominent throughout the entire tumor (termed pure desmoplastic melanoma), whereas
More informationCutaneous Melanoma: Epidemiology (USA) The Sentinel Node in Head and Neck Melanoma. Cutaneous Melanoma: Epidemiology (USA)
The Sentinel Node in Head and Neck Melanoma Cutaneous Melanoma: Epidemiology (USA) 6 th leading cause of cancer among men and women 68,720 new cases of invasive melanoma in 2009 8,650 deaths from melanoma
More informationQuality ID #264: Sentinel Lymph Node Biopsy for Invasive Breast Cancer National Quality Strategy Domain: Effective Clinical Care
Quality ID #264: Sentinel Lymph de Biopsy for Invasive Breast Cancer National Quality Strategy Domain: Effective Clinical Care 2018 OPTIONS FOR INDIVIDUAL MEASURES: REGISTRY ONLY MEASURE TYPE: Process
More informationMeasure #264: Sentinel Lymph Node Biopsy for Invasive Breast Cancer National Quality Strategy Domain: Effective Clinical Care
Measure #264: Sentinel Lymph Node Biopsy for Invasive Breast Cancer National Quality Strategy Domain: Effective Clinical Care 2016 PQRS OPTIONS FOR INDIVIDUAL MEASURES: REGISTRY ONLY DESCRIPTION: The percentage
More informationAustin Radiological Association Nuclear Medicine Procedure LYMPHOSCINTIGRAPHY (Tc-99m-Sulfur Colloid [Filtered])
Austin Radiological Association Nuclear Medicine Procedure LYMPHOSCINTIGRAPHY (Tc-99m-Sulfur Colloid [Filtered]) Overview Indications The Lymphoscintigraphy Study demonstrates the flow of lymph from the
More informationPractice of Axilla Surgery
Summer School of Breast Disease 2016 Practice of Axilla Surgery Axillary Lymph Node Dissection & Sentinel Lymph Node Biopsy 연세의대외과 박세호 Contents Anatomy of the axilla Axillary lymph node dissection (ALND)
More informationCase 1: 79 yr-old woman with a lump in upper outer quadrant of left breast.
Case 1: 79 yr-old woman with a lump in upper outer quadrant of left breast. Giuliano Mariani Regional Center of Nuclear Medicine, University of Pisa Medical School, Pisa (Italy) Relevant history 79-yr
More informationSurgery for Melanoma and What s on the Horizon
and What s on the Horizon Giorgos C. Karakousis, M.D. Assistant Professor of Surgery Perelman School of Medicine at the University of Pennsylvania Background/Overview 76,870 cases of melanoma estimated
More informationSentinel lymph node (SLN) biopsy is a wellestablished
ORIGINAL ARTICLE DISCORDANT LYMPHATIC DRAINAGE PATTERNS REVEALED BY SERIAL LYMPHOSCINTIGRAPHY IN CUTANEOUS HEAD AND NECK MALIGNANCIES Alliric I. Willis, MD, John A. Ridge, MD, PhD Department of Surgical
More information2019 COLLECTION TYPE: MIPS CLINICAL QUALITY MEASURES (CQMS) MEASURE TYPE: Process
Quality ID #264: Sentinel Lymph Node Biopsy for Invasive Breast Cancer National Quality Strategy Domain: Effective Clinical Care Meaningful Measure Area: Appropriate Use of Healthcare 2019 COLLECTION TYPE:
More informationClinical Study Sentinel Lymph Node Detection Using Laser-Assisted Indocyanine Green Dye Lymphangiography in Patients with Melanoma
International Surgical Oncology Volume 2013, Article ID 904214, 4 pages http://dx.doi.org/10.1155/2013/904214 Clinical Study Sentinel Lymph Node Detection Using Laser-Assisted Indocyanine Green Dye Lymphangiography
More informationMelanoma Quality Reporting
Melanoma Quality Reporting September 1, 2013 December 31, 2016 Laurence McCahill, MD Surgical Oncologist Metro Health Surgical Oncology Metro Health Professional Building 2122 Health Drive SW Wyoming,
More informationNegative axillary sentinel node (SN) biopsy (SNB) Improved Sentinel Node Identification by SPECT/CT in Overweight Patients with Breast Cancer
Improved Sentinel Node Identification by SPECT/CT in Overweight Patients with Breast Cancer Hedva Lerman 1, Gennady Lievshitz 1, Osnat Zak 2, Ur Metser 1,3, Shlomo Schneebaum 3,4, and Einat Even-Sapir
More informationWProbe: Exploring new frontiers in radioguided cancer surgery
Wireless gamma probe for radioguided Sentinel lymph Node (SLN) Localization WProbe: Exploring new frontiers in radioguided cancer surgery Precise. Comfortable. Easy Since 2007 ONCOVISION has been fully
More informationby Gamma and Fluorescence
Double Detection of Sentinel Lymph Nodes by Gamma and Fluorescence Sarl au capital de 15 000 RCS PARIS 432 607 562 Siret 432 607 562 00027 APE4646Z 13 rue Raymond Losserand 75014 Paris- France Tél : 33(0)
More informationdeclipse SPECT Imaging Probe Worldwide first registration-free ultrasound fusion with high-resolution 3D SPECT images
declipse SPECT Imaging Probe Worldwide first registration-free ultrasound fusion with high-resolution 3D SPECT images high-resolution 3D SPECT live ultrasound realtime fusion of SPECT / ultrasound Hybrid
More informationSentinel Lymph Node Biopsy Is Valuable For All Cancer. Surgery Grand Rounds Debate October 6, 2008 Joel Baumgartner
Sentinel Lymph Node Biopsy Is Valuable For All Cancer Surgery Grand Rounds Debate October 6, 2008 Joel Baumgartner History Lymphatics first described by Rasmus Bartholin in 1653 Rudolf Virchow postulated
More informationCanadian Scientific Journal. Intraoperative color detection of lymph nodes metastases in thyroid cancer
Canadian Scientific Journal 2 (2014) Contents lists available at Canadian Scientific Journal Canadian Scientific Journal journal homepage: Intraoperative color detection of lymph nodes metastases in thyroid
More informationIs Sentinel Node Biopsy Practical?
Breast Cancer Is Sentinel Node Biopsy Practical? Benefits and Limitations JMAJ 45(10): 444 448, 2002 Shigeru IMOTO *1, Satoshi EBIHARA *2 and Noriyuki MORIYAMA *3 *1 Breast Surgery Division, National Cancer
More informationPrecision Surgery for Melanoma
Precision Surgery for Melanoma Giorgos C. Karakousis, M.D. Assistant Professor of Surgery Perelman School of Medicine at the University of Pennsylvania Background 87,110 cases of melanoma estimated in
More informationCLAUDIU PEŞTEAN 1,2, ELENA BĂRBUŞ 1,2, ANDRA PICIU 3,4, MARIA IULIA LARG 1,2, ALEXANDRINA SABO 1,5, CRISTINA MOISESCU-GOIA 1,5, DOINA PICIU 6,7
Oncology DOI: 10.15386/cjmed-637 SENTINEL LYMPH NODE SCINTIGRAPHY IN CUTANEOUS MELANOMA USING A PLANAR CALIBRATION PHANTOM FILLED WITH TC-99M PERTECHNETATE SOLUTION FOR BODY CONTOURING CLAUDIU PEŞTEAN
More informationTHE ROLE OF CONTEMPORARY IMAGING AND HYBRID METHODS IN THE DIAGNOSIS OF CUTANEOUS MALIGNANT MELANOMA(CMM) AND MERKEL CELL CARCINOMA (MCC)
THE ROLE OF CONTEMPORARY IMAGING AND HYBRID METHODS IN THE DIAGNOSIS OF CUTANEOUS MALIGNANT MELANOMA(CMM) AND MERKEL CELL CARCINOMA (MCC) I.Kostadinova, Sofia, Bulgaria CMM some clinical facts The incidence
More informationInternational prospective validation trial of sentinel node biopsy in cervical cancer
Cervix cancer committee International prospective validation trial of sentinel node biopsy in cervical cancer N Abu-Rustum, F Lécuru, P Mathevet, M Plante. F Bonnetain (Statistics) G Chatellier (Clinical
More informationSentinel Node Biopsy, Introduction and Application of the Technique in a Senology Unit of a District Hospital - Prospective Study.
ISPUB.COM The Internet Journal of Surgery Volume 20 Number 2 Sentinel Node Biopsy, Introduction and Application of the Technique in a Senology Unit of a District Hospital - Prospective Study. Z Sidiropoulou,
More informationCorrespondence should be addressed to Donald R. Lannin;
Hindawi Surgery Research and Practice Volume 2017, Article ID 5924802, 5 pages https://doi.org/10.1155/2017/5924802 Research Article Intraoperative Injection of Technetium-99m Sulfur Colloid for Sentinel
More informationCOMPARATIVE ANALYSIS OF COLON AND RECTAL CANCERS IN SENTINEL LYMPH NODE MAPPING
Trakia Journal of Sciences, Vol. 5, No. 1, pp 10-14, 2007 Copyright 2007 Trakia University Available online at: http://www.uni-sz.bg ISSN 1312-1723 Original Contribution COMPARATIVE ANALYSIS OF COLON AND
More informationMelanoma Surgery Update James R. Ouellette, DO FACS Premier Health Cancer Institute Wright State University Chief, Surgical Oncology Division
Melanoma Surgery Update 2018 James R. Ouellette, DO FACS Premier Health Cancer Institute Wright State University Chief, Surgical Oncology Division Surgery for Melanoma Mainstay of treatment for potentially
More informationTargeting Surgery for Known Axillary Disease. Abigail Caudle, MD Henry Kuerer, MD PhD Dept. Surgical Oncology MD Anderson Cancer Center
Targeting Surgery for Known Axillary Disease Abigail Caudle, MD Henry Kuerer, MD PhD Dept. Surgical Oncology MD Anderson Cancer Center Nodal Ultrasound at Diagnosis Whole breast and draining lymphatic
More informationENHANCED SENTINEL LYMPHOSCINTIGRAPHIC MAPPING IN BREAST TUMOR USING THE GRADED SHIELD TECHNIQUE
ENHANCED SENTINEL LYMPHOSCINTIGRAPHIC MAPPING IN BREAST TUMOR USING THE GRADED SHIELD TECHNIQUE Yu-Wen Chen, Yung-Chang Lai, Chien-Chin Hsu, and Ming-Feng Hou 1 Departments of Nuclear Medicine and 1 Gastroenteric
More informationSentinel Lymph Node Biopsy for Breast Cancer
Sentinel Lymph Node Biopsy for Breast Cancer Registrar Tutorial Adam Cichowitz Surgical Registrar The Royal Melbourne Hospital Sentinel Lymph Node Biopsy Axillary LN status important prognostic factor
More informationNICE diagnostics guidance on intraoperative tests (RD 100i OSNA system and Metasin test) for detecting sentinel lymph node metastases in breast cancer
NICE diagnostics guidance on intraoperative tests (RD 100i OSNA system and Metasin test) for detecting sentinel lymph node metastases in breast cancer NICE provided the content for this booklet which is
More informationperformed to help sway the clinician in what the appropriate diagnosis is, which can substantially alter the treatment of management.
Hello, I am Maura Polansky at the University of Texas MD Anderson Cancer Center. I am a Physician Assistant in the Department of Gastrointestinal Medical Oncology and the Program Director for Physician
More informationNodal staging in localized melanoma. The experience of the Brescia Melanoma Unit
The British Association of Plastic Surgeons (2003) 56, 534 539 Nodal staging in localized melanoma. The experience of the Brescia Melanoma Unit Giorgio Manca a, *, Fabio Facchetti b, Claudio Pizzocaro
More informationNorthumbria Healthcare NHS Foundation Trust. Breast Sentinel Lymph Node Biopsy. Issued by the Breast Team
Northumbria Healthcare NHS Foundation Trust Breast Sentinel Lymph Node Biopsy Issued by the Breast Team Why do my Lymph Nodes require investigation? The lymphatic system is a pathway of lymph vessels and
More informationUse of the dye guided sentinel lymph node biopsy method alone for breast cancer metastasis to avoid unnecessary axillary lymph node dissection
456 Use of the dye guided sentinel lymph node biopsy method alone for breast cancer metastasis to avoid unnecessary axillary lymph node dissection TOMOKO TAKAMARU 1, GORO KUTOMI 1, FUKINO SATOMI 1, HIROAKI
More information16/09/2015. ACOSOG Z011 changing practice. Presentation outline. Nodal mets #1 prognostic tool. Less surgery no change in oncologic outcomes
ACOSOG Z011 changing practice The end of axillary US/FNA? Preoperative staging of the axilla in the era of Z011 Adena S Scheer MD MSc FRCSC Surgical Oncologist, St. Michael s Hospital Assistant Professor,
More informationHybrid Imaging SPECT/CT PET/CT PET/MRI. SNMMI Southwest Chapter Aaron C. Jessop, MD
Hybrid Imaging SPECT/CT PET/CT PET/MRI SNMMI Southwest Chapter 2014 Aaron C. Jessop, MD Assistant Professor, Department of Nuclear Medicine UT MD Anderson Cancer Center, Houston, Texas Complimentary role
More informationSENTINEL LYMPH NODE CONCEPT IN OESOPHAGEAL CANCER
SENTINEL LYMPH NODE CONCEPT IN OESOPHAGEAL CANCER Sarah K Thompson, M.D. Queenstown ANZGOSA Mtg, 2010 Sentinel Lymph Node (SLN) Sentinel Lymph Node (SLN) Not always on a direct drainage pathway Not always
More informationBreast conservation surgery and sentinal node biopsy: Dr R Botha Moderator: Dr E Osman
Breast conservation surgery and sentinal node biopsy: Dr R Botha Moderator: Dr E Osman Breast anatomy: Breast conserving surgery: The aim of wide local excision is to remove all invasive and in situ
More informationBREAST CANCER SURGERY. Dr. John H. Donohue
Dr. John H. Donohue HISTORY References to breast surgery in ancient Egypt (ca 3000 BCE) Mastectomy described in numerous medieval texts Petit formulated organized approach in 18 th Century Improvements
More informationSentinel lymph node biopsy
INFORMATION FOR PATIENTS Sentinel lymph node biopsy Dermatology department This leaflet has been written to give you information about having a sentinel lymph node biopsy. It is a guide only; your healthcare
More informationSentinel Lymph Node Biopsies in Cutaneous Melanoma: A systematic review of the literature. Sasha Jenkins
Sentinel Lymph Node Biopsies in Cutaneous Melanoma: A systematic review of the literature By Sasha Jenkins A Master s Paper submitted to the faculty of the University of North Carolina at Chapel Hill in
More informationLymphoseek (technetium Tc 99m tilmanocept) Injection
Lymphoseek (technetium Tc 99m tilmanocept) Injection A Novel Receptor-Targeted Lymphatic Mapping Agent Karen B. Randall, B.S., CNMT Navidea Biopharmaceuticals Medical Science Liaison Lymphoseek (technetium
More informationCase 4: 27 yr-old woman with history of kidney stones and hyperparathyroidism.
Case 4: 27 yr-old woman with history of kidney stones and hyperparathyroidism. Giuliano Mariani Regional Center of Nuclear Medicine, University of Pisa Medical School, Pisa (Italy) Hyperparathyroidism
More informationInnovating image-guided surgery: Introducing multimodal approaches for sentinel node detection Brouwer, O.R.
UvA-DARE (Digital Academic Repository) Innovating image-guided surgery: Introducing multimodal approaches for sentinel node detection Brouwer, O.R. Link to publication Citation for published version (APA):
More informationSentinel Lymph Node Identification in Breast Cancer - Comparison of Planar Scintigraphy and SPECT/CT
The Open Nuclear Medicine Journal, 2012, 4, 5-13 5 Open Access Sentinel Lymph Node Identification in Breast Cancer - Comparison of Planar Scintigraphy and SPECT/CT Otakar Kraft *,1,2 and Martin Havel 1
More informationA specific mapping study using fluorescence sentinel lymph node detection in patients with
1 2 3 A specific mapping study using fluorescence sentinel lymph node detection in patients with intermediate- and high-risk prostate cancer undergoing extended pelvic lymph node dissection 4 5 6 Daniel
More informationBio-Optical Devices in Indocyanine Green Fluorescence Guided Sentinel Node Biopsy for Breast Cancer
78 The Open Surgical Oncology Journal, 2010, 2, 78-82 Open Access Bio-Optical Devices in Indocyanine Green Fluorescence Guided Sentinel Node Biopsy for Breast Cancer Toshiyuki Kitai *,1, Masahiro Kawashima
More informationUvA-DARE (Digital Academic Repository)
UvA-DARE (Digital Academic Repository) In search of the sentinel node : validation and sophistication of lymphatic mapping and sentinel node biopsy in breast cancer and melanoma van der Ploeg, I.M.C. Link
More informationMelanoma. Kaushik Mukherjee MD A. Scott Pearson MD
Melanoma Kaushik Mukherjee MD A. Scott Pearson MD Disclosures You still have to study Not all inclusive No Western blots Extensive use of Google Image Search and Sabiston Melanoma Basics 8 th most common
More informationversion 1.0, approved June 15, 2002 I. Purpose Background Information and Definitions
Society of Nuclear Medicine Procedure Guideline for Lymphoscintigraphy and the Use of Intraoperative Gamma Probe for Sentinel Lymph Node Localization in Melanoma of Intermediate Thickness version 1.0,
More informationNuclear medicine in oncology. 1. Diagnosis 2. Therapy
Nuclear medicine in oncology 1. Diagnosis 2. Therapy Diagnosis - Conventional methods - Nonspecific radiopharmaceuticals cumulating in tumours - Specific radiopharmaceuticals (receptor- and immunoscintigraphy)
More informationReview Article Lymphoscintigraphy Defines New Lymphatic Pathways from Cutaneous Melanoma Site: Clinical Implications and Surgical Management
Radiology Research and Practice Volume 2011, Article ID 817043, 5 pages doi:10.1155/2011/817043 Review Article Lymphoscintigraphy Defines New Lymphatic Pathways from Cutaneous Melanoma Site: Clinical Implications
More information1. Written information to patient /GP: fax ASAP to GP & offer copy of consultation letter.
Skin Cancer follow up guidelines If NEW serious diagnosis given: 1. Written information to patient /GP: fax ASAP to GP & offer copy of consultation letter. 2. Free prescription information details. 3.
More informationLymphatic Mapping in Solid Neoplasms: State of the Art
The application and the effects of the lymphatic mapping technique in patients with several different epithelial cancers are reviewed. Wassily Kandinsky (1866-1944). Improvisation V (Park), 1911. Lymphatic
More informationT he purpose of axillary node dissection in breast cancer
546 ORIGINAL ARTICLE Sentinel lymph node biopsy in breast cancer patients after overnight migration of radiolabelled sulphur colloid N Lamichhane, K W Shen, C L Li, Q X Han, Y J Zhang, Z M Shao, Z Z Shen...
More informationAim of the study. Patients: Intervention: Materials and methods
Radioguided Sentinel Node Biopsy and Predictive Value in Lip and Oral Cavity Squamous Cell Carcinoma M.G. Vigili 1, A. Marzetti 1, G. Mancini 1, C. Potenza 2, A Caggiati 2, F. Gabrielli 2, S. Rahimi 3,
More informationThe EANM clinical and technical guidelines for lymphoscintigraphy and sentinel node localization in gynaecological cancers
DOI 10.1007/s00259-014-2732-8 GUIDELINES The EANM clinical and technical guidelines for lymphoscintigraphy and sentinel node localization in gynaecological cancers Francesco Giammarile M. Fani Bozkurt
More informationManagement of the Axilla at Initial Surgery Manejo da Axila em Cirurgia Inicial
DISCIPLINA DE MASTOLOGIA ESCOLA PAULISTA DE MEDICINA UNIVERSIDADE FEDERAL DE SÃO PAULO Management of the Axilla at Initial Surgery Manejo da Axila em Cirurgia Inicial Disciplina de Mastologia Prof. Dr.
More informationBreast Surgery When Less is More and More is Less. E MacIntosh, MD June 6, 2015
Breast Surgery When Less is More and More is Less E MacIntosh, MD June 6, 2015 Presenter Disclosure Faculty: E. MacIntosh Relationships with commercial interests: None Mitigating Potential Bias Not applicable
More informationPROTOCOL SENTINEL NODE BIOPSY (NON OPERATIVE) BREAST CANCER - PATHOLOGY ASSESSMENT
PROTOCOL SENTINEL NODE BIOPSY (NON OPERATIVE) BREAST CANCER - PATHOLOGY ASSESSMENT Author: Dr Sally Ann Hales On behalf of the Breast and pathology CNGs Written: March 2005 Reviewed by CNG: June 2009 &
More informationORIGINAL ARTICLE. (SLN) biopsy is revolutionizing
ORIGINAL ARTICLE Management of Malignant Melanoma of the Head and Neck Using Dynamic Lymphoscintigraphy and Gamma Probe Guided Sentinel Lymph Node Biopsy Grant W. Carlson, MD; Douglas R. Murray, MD; Robert
More informationLYMPHATIC DRAINAGE IN THE HEAD & NECK
LYMPHATIC DRAINAGE IN THE HEAD & NECK Like other parts of the body, the head and neck contains lymph nodes (commonly called glands). Which form part of the overall Lymphatic Drainage system of the body.
More informationLymphoscintigraphy is a special type of nuclear medicine imaging that provides pictures called scintigrams of the lymphatic system.
Scan for mobile link. Lymphoscintigraphy Lymphoscintigraphy helps evaluate your body s lymphatic system for disease using small amounts of radioactive materials called radiotracers that are typically injected
More informationSentinel Node Biopsy in the Treatment of Oral Cancer. Patient Information Leaflet
Sentinel Node Biopsy in the Treatment of Oral Cancer Patient Information Leaflet Introduction Please read carefully through this information sheet, which describes a new procedure we are providing at this
More informationAustin Radiological Association Nuclear Medicine Procedure PROSTATE CANCER STUDY (In-111-Capromab Pendetide [ProstaScint ])
Austin Radiological Association Nuclear Medicine Procedure PROSTATE CANCER STUDY (In-111-Capromab Pendetide [ProstaScint ]) Overview Indications The Prostate Cancer Study with an indium-111 labeled murine
More informationSentinel lymph node biopsy for melanoma
Sentinel lymph node biopsy for melanoma Delivering the best in care UHB is a no smoking Trust To see all of our current patient information leaflets please visit www.uhb.nhs.uk/patient-information-leaflets.htm
More informationUvA-DARE (Digital Academic Repository)
UvA-DARE (Digital Academic Repository) In search of the sentinel node : validation and sophistication of lymphatic mapping and sentinel node biopsy in breast cancer and melanoma van der Ploeg, I.M.C. Link
More informationSentinel Lymph Node Biopsy in Other Tumours: Sentinel Lymph Node Biopsy in Other Tumours. Methodology. Results. Key Questions to Consider
Sentinel Lymph Node Biopsy in Other Tumours Dr. Rona Cheifetz Surgical Oncology Update November 24, 2006 Sentinel Lymph Node Biopsy in Other Tumours: An Operation Looking for an Application Dr. Rona Cheifetz
More informationIndex. Note: Page numbers of article titles are in boldface type. A Age as factor in melanoma, Anorectal melanoma RT for, 1035
Index Note: Page numbers of article titles are in boldface type. A Age as factor in melanoma, 947 948 Anorectal melanoma RT for, 1035 B Bacille Calmette-Guerin (BCG) in melanoma, 1008 BCG. See Bacille
More informationComparison of intra-operative gamma probe detection with postoperative SPECT/CT of sentinel nodes related to the ovary.
Journal of Nuclear Medicine, published on October 13, 2016 as doi:10.2967/jnumed.116.183426 Comparison of intra-operative gamma probe detection with postoperative SPECT/CT of sentinel nodes related to
More informationUpdate on Sentinel Node Biopsy in Endometrial Cancer: Feasibility, Technique, Impact
Update on Sentinel Node Biopsy in Endometrial Cancer: Feasibility, Technique, Impact Bjørn Hagen, MD, PhD St Olavs Hospital Trondheim University Hospital Trondheim, Norway Endometrial Cancer (EC) The most
More informationI. Cancer staging problem
Instrumentation Lab (Craig Levin) Angela Craig Peter Jin Frezghi Guillem Billie Garry Research interests (by imaging modality) I. High resolution radionuclide imaging : positron emission tomography (PET)
More informationMorphological characteristics of the primary tumor and micrometastases in sentinel lymph nodes as a predictor of melanoma progression
Morphological characteristics of the primary tumor and micrometastases in sentinel lymph nodes as a predictor of melanoma progression M.N. Kukushkina, S.I. Korovin, O.I. Solodyannikova, G.G. Sukach, A.Yu.
More informationNonvisualization of sentinel node by lymphoscintigraphy in advanced breast cancer
Radiology Case Reports Nonvisualization of sentinel node by lymphoscintigraphy in advanced breast cancer Volume 5, Issue 3, 2010 Brian Wosnitzer, MD; Rosna Mirtcheva, MD; and Munir Ghesani, MD Previous
More informationImpact of Prognostic Factors
Melanoma Prognostic Factors: where we started, where are we going? Impact of Prognostic Factors Staging Management Surgical intervention Adjuvant treatment Suraj Venna, MD Assistant Clinical Professor,
More informationEight false negative sentinel node procedures in breast cancer: what went wrong?
EJSO 2003; 29: 336±340 doi:10.1053/ejso.2002.1379 Eight false negative sentinel node procedures in breast cancer: what went wrong? S. H. Estourgie*, O. E. Nieweg*, R. A. ValdeÂs Olmos², E. J. Th. Rutgers*,
More informationGeneral Surgery Curriculum Royal Australasian College of Surgeons, General Surgeons Australia & New Zealand Association of General Surgeons
General Surgery Curriculum Royal Australasian College of Surgeons, General Surgeons Australia & New Zealand Association of General Surgeons MODULE TITLE: SURGICAL ONCOLOGY 5-May-2013 DEVELOPED BY: Bruce
More informationKentaro Tanaka, 1 Hiroki Mori, 1 Mutsumi Okazaki, 1 Aya Nishizawa, 2 and Hiroo Yokozeki Introduction. 2. Case Presentation
Case Reports in Oncological Medicine Volume 2013, Article ID 259326, 4 pages http://dx.doi.org/10.1155/2013/259326 Case Report Long-Term Treatment Outcome after Only Popliteal Lymph Node Dissection for
More informationFISABIO HOSPITAL UNIVERSITARIO DOCTOR PESET NUCLEAR MEDICINE
HOSPITAL UNIVERSITARIO DOCTOR PESET HEAD OF RESEARCH SECTION ELISA CABALLERO CALABUIG CABALLERO_ELI@GVA.ES SAN LÁZARO, S/N, 1ª PLANTA / 46017 VALENCIA / SPAIN The research activity of the Department of
More informationThe Role of Selective Lymphadenectomy in Breast Cancer
The Role of Selective Lymphadenectomy in Breast Cancer Douglas Reintgen, MD; Emmanuella Joseph, MD; Gary H. Lyman, MD, MPH; Tim Yeatman, MD; Lodovico Balducci, MD; Ni Ni Ku, MD; Claudia Berman, MD; Alan
More informationInvestigating the role of SPECT/CT in dynamic sentinel lymph node biopsy for penile cancers
Eur J Nucl Med Mol Imaging (2017) 44:1176 1184 DOI 10.1007/s00259-017-3636-1 ORIGINAL ARTICLE Investigating the role of SPECT/CT in dynamic sentinel lymph node biopsy for penile cancers Ziauddin Zia Saad
More informationDRAINAGE PATTERN OF THE UPPER MEDIAL QUADRANT OF THE BREAST IN YOUNG HEALTHY WOMEN AFTER SUBDERMAL INJECTION: A LYMPHSCINTIGRAPHIC STUDY
197 Lymphology 38 (2005) 197-201 DRAINAGE PATTERN OF THE UPPER MEDIAL QUADRANT OF THE BREAST IN YOUNG HEALTHY WOMEN AFTER SUBDERMAL INJECTION: A LYMPHSCINTIGRAPHIC STUDY A. Tassenoy, P. van der Veen, P.
More informationWhat Is a Sentinel Node? Re-Evaluating the 10% Rule for Sentinel Lymph Node Biopsy in Melanoma
Journal of Surgical Oncology 2007;95:623 628 What Is a Sentinel Node? Re-Evaluating the 10% Rule for Sentinel Lymph Node Biopsy in Melanoma HIDDE M. KROON, MD, 1 LORI LOWE, MD, 2 SANDRA WONG, MD, 1 DOUG
More informationDetection of the sentinel lymph node in breast cancer
in breast cancer Santosh K. Somasundaram, Dennis W. Chicken, and Mohammed R. S. Keshtgar * Department of Surgery, Royal Free and University College Medical School, University College London, London, UK
More informationTranslating Evidence into Practice: Primary Cutaneous Melanoma Guidelines. Sentinel Lymph Node Biopsy
American Academy of Dermatology 2018 Annual Meeting San Diego, CA, February 17, 2018 Translating Evidence into Practice: Primary Cutaneous Melanoma Guidelines. Sentinel Lymph Node Biopsy Christopher Bichakjian,
More informationSentinel Lymph Node Detection in Patients with Oral Cancer by MR Lymphography using Superparamagnetic Iron Oxide
Send Orders for Reprints to reprints@benthamscience.net 14 The Open Otorhinolaryngology Journal, 2013, 7, 14-18 Open Access Sentinel Lymph Node Detection in Patients with Oral Cancer by MR Lymphography
More informationIncreasing Age Is Associated with Worse Prognostic Factors and Increased Distant Recurrences despite Fewer Sentinel Lymph Node Positives in Melanoma
Increasing Age Is Associated with Worse Prognostic Factors and Increased Distant Recurrences despite Fewer Sentinel Lymph Node Positives in Melanoma A. J. Page, Emory University A. Li, Emory University
More information5/8/2014. AJCC Stage Introduction and General Rules. Acknowledgements* Introduction. Melissa Pearson, CTR North Carolina Central Cancer Registry
AJCC Stage Introduction and General Rules Linda Mulvihill Public Health Advisor NCRA Annual Meeting May 2014 National Center for Chronic Disease Prevention and Health Promotion Division of Cancer Prevention
More informationIndex. Surg Oncol Clin N Am 16 (2007) Note: Page numbers of article titles are in boldface type.
Surg Oncol Clin N Am 16 (2007) 465 469 Index Note: Page numbers of article titles are in boldface type. A Adjuvant therapy, preoperative for gastric cancer, staging and, 339 B Breast cancer, metabolic
More informationORIGINAL ARTICLE. Reliability of Sentinel Lymph Node Mapping With Biopsy for Head and Neck Cutaneous Melanoma
ORIGINAL ARTICLE Reliability of Sentinel Lymph Node Mapping With Biopsy for Head and Neck Cutaneous Melanoma Cecelia E. Schmalbach, MD; Brian Nussenbaum, MD; Riley S. Rees, MD; Jennifer Schwartz, MD; Timothy
More informationOblique view of preoperative lymphoscintigraphy improves detection of sentinel lymph nodes in esophageal cancer
CASE REPORT Annals of Nuclear Medicine Vol. 19, No. 8, 719 723, 2005 Oblique view of preoperative lymphoscintigraphy improves detection of sentinel lymph nodes in esophageal cancer Chikako TANAKA,* Hirofumi
More informationHead & Neck Squamous Carcinoma: Artifacts, Challenges, and Controversies. Agenda
Head & Neck Squamous Carcinoma: Artifacts, Challenges, and Controversies Jennifer L. Hunt, MD, MEd Aubrey J. Hough Jr, MD, Endowed Professor of Pathology Chair of Pathology and Laboratory Medicine University
More informationCover Page. The handle holds various files of this Leiden University dissertation
Cover Page The handle http://hdl.handle.net/1887/44147 holds various files of this Leiden University dissertation Author: Berg, Nynke van den Title: Advancing surgical guidance : from (hybrid) molecule
More information