Long-Yuan Li ( 李龍緣 ), Ph.D.

Transcription

1 Long-Yuan Li ( 李龍緣 ), Ph.D. Office Address: Center for Molecular Medicine China Medical University Hospital 9F, No. 6, Hsueh-Shih Road, Taichung 404, Tel: ext Fax: lyl@mail.cmu.edu.tw Education Ph.D., Graduate Institute of Microbiology, College of Medicine, National University, Taipei, Professional Experience 1/2007~ Associate Director, Center for Molecular Medicine, China Medical University Hospital 6/2006~ Associate Research Fellow, Center for Molecular Medicine, China Medical University Hospital 8/2006~ Assistant Professor, College of Medicine, China Medical University 8/2006~ Assistant Professor, Asia University Postdoctoral Fellow, Department of Molecular and Cellular Oncology, The University of Texas M. D. Anderson Cancer Center, Houston, Texas, USA Postdoctoral Fellow, President s Laboratory, National Health Research Institutes, Taipei, Awards 2009 Excellence in Research Funding Award, China Medical University, Taichung, 2006 Scholar-in-Training Award, American Association for Cancer Research (AACR), Washington D.C., USA 2006 Trainee Excellence Award, The University of Texas M. D. Anderson Cancer Center, Houston, Texas, USA 2002 Annual Outstanding Ph.D. Student Award for Excellence in Publication, College of Medicine, National University, Taipei, 1

2 2002 Dr. Chien-Tien Hsu s Award for Outstanding Dissertation, 10th Symposium on Recent Advances in Cellular and Molecular Biology, 1995 Professor Zhi-Zhong Yan Scholar Award, Chinese Society of Microbiology, 1995 Mr. Rui-Heng Liu Scholar Award, National Defense Medical Center, Taipei, 1992 Mr. Xiong-Zheng Lin Scholar Award, Board of Directors of Mr. Xiong-Zheng Lin, Research Interest Cancer biology, Molecular and cellular biology, Gene therapy, Tumor virology Grant Funding 1. 1/ /2011 Principle Investigator The effects of nuclear ErbB-2 on tumor progression and metastasis (National Health Research Institutes) 2. 11/2006-7/2007 Principle Investigator The molecular mechanism of ErbB-2 nuclear translocation and its role in tumor progression and metastasis (National Science Council) 3. 12/ /2010 Principle Investigator Adipocyte and osteoblast differentiation of mesenchymal stem cells (National Science Council) 4. 1/ /2009 Principle Investigator Development of novel therapeutic strategies for hepatocellular carcinoma (Department of Health) 5. 12/ /2010 Co- Principle Investigator (PI: Dr. Mien-Chie Hung) Signal pathways and epigenetic regulation of stem cells- Administrative Core (National Science Council) 6. 5/2008-4/2011 Co- Principle Investigator (PI: Dr. Mien-Chie Hung) Development of novel strategies for lung cancer therapy (Department of Health) 2

3 Publications 1. Yang JY, Zong CS, Xia W, Yamaguchi H, Ding Q, Xie X, Lang JY, Lai CC, Chang CJ, Huang WC, Huang H, Kuo HP, Lee DF, Li LY, Lien HC, Cheng X, Chang KJ, Hsiao CD, Tsai FJ, Tsai CH, Sahin AA, Muller WJ, Mills GB, Yu D, Hortobagyi GN, Hung MC. (2008). ERK promotes tumorigenesis by inhibiting FOXO3a via MDM2-mediated degradation. Nat. Cell Biol. 10(2): Qingqing Ding, Longfei Huo, Jer-Yen Yang, Weiya Xia, Yongkun Wei, Yong Liao, Chun-Ju Chang, Dung-Fang Lee, Yan Yang, Chien-Chen Lai, Chia-Jui Yen, Yun-yu Chen, Jung-Mao Hsu, Hsu-Ping Kuo, Chun-Yi Lin, Fuu-Jen Tsai, Long-Yuan Li, Chang-Hai Tsai, Mien-Chie Hung (2008) Downregulation of Mcl-1 through inhibiting Erk/Pin1 pathway by Sorafenib facilitates chemosensitization in breast cancer. Cancer Res 68 (15), Lee, D. F., Kuo, H. P., Chen, C. T., Hsu, J. M., Sun, H. L., Chou, C. K., Wei, Y., Li, L.Y., Ping, B., Huang, W. C., He, X., Hung, J. Y., Lai, C. C., Ding, Q., Su, J. L., Yang, J. Y., Sahin, A.A., Hortobagyi, G.N., Tsai, F. J., Tsai, C. H. and Hung, M. C. (2007). IKKβ Suppression of TSC1 Links Inflammation and Tumor Angiogenesis via the mtor Pathway. Cell 130(3), Ding, Q., He, X., Hsu, J. M., Xia, W., Chen, C. T., Li, L. Y., Lee, D. F., Liu, J. C., Zhong, Q., Wang, X. and Hung, M. C. (2007). Degradation of Mcl-1 by β-trcp mediates GSK-3β-induced tumor suppression and chemosensitization. Mol. Cell. Biol. 27, Ding, Q., He, X., Xia, W., Hsu, J. M., Chen, C. T., Li, L. Y., Lee, D. F., Yang, J.Y., Xie, X., Liu, J.C. and Hung, M.C. (2007). Mcl-1 inversely correlates with GSK-3β activity and associates with poor prognosis in human breast cancers. Cancer Res. 67, Wang, S. C., Nakajima, Y., Yu, Y. L., Xia, W., Chen, C. T., Yang, C. C., McIntush, E. W., Li, L. Y., Hawke, D. H., Kobayashi, R., and Hung, M. C. (2006). Tyrosine phosphorylation controls PCNA function through protein stability. Nat. Cell Biol. 8,

4 7. Li, L. Y., Liu, M. Y., Shih, H. M., Tsai, C. H. and Chen, J. Y. (2006). Human cellular protein VRK2 specifically interacts with Epstein-Barr virus BHRF1, a homologue of Bcl-2, and enhances cell survival. J. Gen. Virol. Pt 10, Li, L. Y., Giri, D. K., Ali-Seyed, M., Lee, D. F., Ling, P., Bartholomeusz G., Wang, S. C. and Hung, M. C. (2005). Endosomal transport of ErbB-2: mechanism for nuclear entry of the cell surface receptor. Mol. Cell. Biol. 25, (, equal contribution). (Part of data in this paper was included in the "Analyze the data" section of Chapter 13: Moving proteins into membranes and organelles on the Instructor's resource CD-ROM which accompanied the Molecular Cell Biology, Harvey Lodish et al., 6th Edition. 2008, published by W. H. Freeman and Company). 9. Chou, S. P., Tsai, C. H., Li, L. Y., Liu, M. Y., and Chen, J. Y. (2004). Characterization of a novel monoclonal antibody to the BHRF1 protein of Epstein-Barr virus. Hybrid Hybridomics. 23, Li, L. Y., Shih, H. M., Liu, M. Y., and Chen, J. Y. (2001). The cellular protein PRA1 modulates the anti-apoptotic activity of Epstein-Barr virus BHRF1, a homologue of Bcl-2, through direct interaction. J. Biol. Chem. 276, Liu, M. Y., Shih, Y. Y., Li, L. Y., Chou, S. P., Sheen, T. S., Chen, C. L., Yang, C. S., and Chen, J. Y. (2000). Expression of the Epstein-Barr virus BHRF1 gene, a homologue of Bcl-2, in nasopharyngeal carcinoma tissue. J. Med. Virol. 61, Tsao, Y. P., Li, L. Y., Tsai, T. C., and Chen, S. L. (1996). Human papillomavirus type 11 and 16 E5 represses p21 (WafI/SdiI/CipI) gene expression in fibroblasts and keratinocytes. J. Virol. 70, Chen, S. L., Lin, Y. K., Li, L. Y., Tsao, Y. P., Lo, H. Y., Wang, W. B., and Tsai, T. C. (1996). E5 proteins of human papillomavirus types 11 and 16 transactivate the c-fos promoter through the NF1 binding element. J. Virol. 70, Tsao, Y. P., Kuo, S. W., Li, S. F., Tsai, T. C., Li, L. Y., and Chen, S. L. (1995). Human papillomavirus 11 E5a delays the growth restriction induced by temperature shift in temperature-sensitive simian virus 40 T antigen-immortalized keratinocytes. Biochem. Biophys. Res. Commun. 217, Book 醫護微生物及免疫學 ( 第三版 ), (ISBN ) 林振文 徐媛曼 項千芸 方世華 李龍緣 林應如 洪千惠 許晉銓 萬磊 湯智昕 賴志河 * 4

5 Arthur M. Lesk: Introduction to Bioinformatics, (ISBN: ) 吳錫金 侯庭鏞 方世華 林振文 項千芸 李龍緣 林應如 許晉銓 萬磊 徐媛曼 洪千惠 湯智昕 賴怡琪 賴志河 * Symposium Presentations 1. Endosomal transport of ErbB-2: mechanism for nuclear entry of the cell surface receptor (2006). American Association for Cancer Research (AACR) Annual Meeting 2006, Washington D.C., USA (oral presentation) 2. Endosomal transport of ErbB-2: mechanism for nuclear entry of the cell surface receptor (2006). Society of Cinese Bioscientists in America (SCBA) Texas Chapter Annual Symposium, Houston, Texas, USA (oral presentation) 3. Novel Signaling Pathway: Translocation of Membrane Receptor to the Nucleus (2007). The 1 st International Cancer Symposium, Taichung, (oral presentation) 4. Nuclear translocation of ErbB-2 via Sec61-mediated retrotranslocation (2007). Growth factor receptor tyrosine kinases in mitogenesis, morphogenesis and tumorigenesis, The Federation of American Societies for Experimental Biology (FASEB), Tucson, Arizona, USA (poster presentation) 5. ER-associated degradation pathway is involved in nuclear trafficking of ErbB-2 (2008). The 48 th Annual Meeting of the American Society for Cell Biology, San Francisco, CA, USA (poster presentation) 5