NCI s Office of of Centers, Training & Resources: Fostering Progress in in Cancer Health Disparities Research

Transcription

1 NCI s Office of of Centers, Training & Resources: Fostering Progress in in Cancer Health Disparities Research July July 17-19, 17-19, Cancer Cancer Health Health Disparities Disparities Summit Summit Bethesda, Bethesda, Maryland Maryland Ernest Hawk, MD, MPH National Cancer Institute Office of Centers, Training & Resources

2 OCTR Mission Major OCTR goals Cancer research infrastructure & capacity building Translational cancer research Anticipating cancer research manpower needs Ensuring diversity among cancer scientists Goals are supported by OCTR grants programs Cancer Centers Branch (CCB) Organ Systems Branch (OSB) Cancer Training Branch (CTB) Comprehensive Minority Biomedical Branch (CMBB)

3 OCTR s Contributions to the Strategic Goal of Overcoming Cancer Health Disparities Institutional health disparities training & research capacity building Research in cancer health disparities Outreach & education efforts to underserved populations Training Persons from minority/underserved groups for cancer research careers For research careers in health disparities Education of professionals in health disparities

4 Cancer Centers - Mission To foster excellence in research across a broad spectrum of scientific and medical concerns relevant to cancer & to extend the benefits of research to patients, their families, and the general public through clinical care, outreach, and education. - Support for 61 centers - More than $240M in 2005

5 NCI-Designated Cancer Centers Characteristics & Components Cancer Focus Intra- & Interdisciplinary Coordination & Collaboration NCI-designated Cancer Center Strong Center Director Organizational Capabilities Institutional Commitment Adequate & Appropriate Facilities Administration Senior Leadership Staff Investigators Planning & Evaluation Scientific Programs Shared Resources - Biostatistics, informatics, etc. Protocol Review & Monitoring System Protocol-specific Research Support Data & Safety Monitoring Data Sharing Developmental Funds - Pilot projects, recruitment, new shared resources, new technologies/methodologies, interim support

6 Current and Emerging NCI Cancer Centers Revised 10/10/05 Cancer Center (22) Comprehensive Cancer Center (39) Planning Grant (7)

7 11/29/2002 Vision for the SPORE Program Phase 1 Pilot Translational Research Concept Breast Prostate Lung SPOREs Ovarian SPOREs Phase 2 Expansion Plan to All Organ Sites Major Organ Sites Reached Critical Density Phase 3 Scientific Diversification Minor Organ Sites Reach Critical Density GI SPOREs Pre-clinical Development Focus Organ-Disease Focus Human Molecular Targets Focus Phase 1 Emphasis on Basic Research into Pre-clinical Studies Initiate Human End Point Studies Phase 2 Emphasis on Human End Point Studies Inter-SPORE Collaborations-same site Initiate inter-site dialogue Initiate linkages to other programs Phase 3 Emphasis on inter-site research Common, molecular mechanisms for interventions Links to other NCI programs Partnerships, collaborations with industry

8 SPOREs & Cancer Health Disparities Research Funding translational research on health disparities Training minorities for careers in translational research (with CMBB) Increasing racial/ethnic diversity in biological specimens available in tissue repositories Tracking minority participation in early-phase translational/clinical trials funded by SPOREs

9 Cancer Training Branch Support Emphasis on endangered disciplines Clinical research, cancer prevention, control, behavior & population science Minority health/health disparities support R25 & K07 mechanisms Overall, more than $150M in FY05

10 Scope of CTB Training & Career Development Opportunities Fellowships Career (K) Awards Career Timeline grad student postdoc new faculty established faculty T32/K12/R25T K22, K25 F33, K05, K24, K25 T32, R25T White 103 AA 3 Asian 24 Hispanic 1 Unknown 6 F32, K01, K07, K08, K23, K25 Research (R) Grant

11 CTB R25E Grants Education Approach Grant Title Short term Research Training Resource Building & Community Outreach Increasing Diversity in Cancer Clinical Research Minority Pre-Doctoral Education to Reduce Disparities Cancer Education Community Health Aides Alaska Cancer Control Capacity Building Native Researchers Deaf Community Cancer Diffusion Strategies Sowing the Seeds: A Program for Latinas Sustaining Breast Cancer Control w Community Stylists Long-term Training Kentucky Cancer Prevention & Control Training Program Cancer Control Training in Multi-ethnic Hawaii

12 CMBB Mission Increase the number of competitive minorities in cancer research Raise the competitive research capacity of Minority-Serving Institutions (MSI) Serve as a resource/model for U.S. programs/organizations with similar objectives

13 CMBB Strategies to Reduce Cancer Health Disparities 1. Continuing Umbrella of Research Experiences (CURE) Train underrepresented minority individuals to become competitive cancer researchers 2. Minority-Serving Institution/Cancer Center Partnership (MI/CCP) Program Increase MSI cancer research capabilities Increase underrepresented minority researchers Improve NCI-designated CC activities that address underrepresented minority populations

14 Continuing Umbrella Research Experiences High School Undergrad Predoctoral Postdoctoral Junior Investigator Research Supplements Supplements to the CURE: Cancer Center Grant: P30 Training Grants:T32 Cancer Education Grant: R25T Cancer Center: P30 MD/POR Clinical Oncology Training Grants: K12 R 0 Fellowships: F31 Career Awards: K01 K08 K23 Transition Career: K22 1

15 CMBB Career Development Portfolio CURE Study Site Target Population Breast Cancer Chemoprevention: Role of SES, Ethnic/Racial Background, Knowledge & Attitudes Diet, Colon Cancer & Cancer Communications Identification of Elderly AA Women at Risk for Diagnosis of Late-stage Breast Cancer Breast Cancer Prevention: Differential Trust & Cancer Care Smoking Intervention Smoking & Weight Control Baylor College of Medicine U. of NC FL A&M U. Stanford U. U. of MN U. of HI AA, Hispanic, Caucasian AA, Caucasian AA women AA AI (Ojibwe) Hispanic women

16 CMBB Research Training & Career Development Awardees/Appointments* (by FY) * Does not include trainees supported by U54 & U56 grants Number Number of Trainees Yearly % Change Fiscal Year

17 Current NCI-Sponsored Minority Serving Institution-Cancer Center Partnerships Guam U54-3 partnerships U56-11 partnerships P20-9 partnerships University of Puerto Rico

18 Future Opportunities to Advance NCI s Mission to Reduce Health Disparities Databases Track health disparities research conducted by cancer centers & SPOREs Coordination Align research areas of emphasis & training program priorities Assessment tools Evaluate health disparities training New Initiatives (TRWG, CaBIG)

19 Acknowledgements H. Nelson Aguila Marilyn Gaston Jorge Gomez Belinda Locke Peter Ogunbiyi Sanya Springfield Devi Vembu Jaye Viner Linda Weiss