American Cancer Society Research Programs

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1 American Cancer Society Research Programs The American Cancer Society dedicates more money to cancer research than any other private, not-for-profit, non-government funder of cancer research in the United States. The Society s research program has 6 components: Extramural Grants, and the 5 programs that make up Intramural Research: Epidemiology, Surveillance and Health Services Research, Econmic & Health Policy Research, the Behavioral Research Center, and the Statistics and Evaluation Center. Who does the Society give research dollars to? The Society is currently supporting investigators at more than 200 leading medical schools, universities, and research institutions across the nation. How does the Society define research? The American Cancer Society uses the following mutually exclusive definitions: Basic cancer research: Research seeking to answer fundamental questions about the nature of cancer, and that is directed towards understanding the mechanisms and concepts related to the development or prevention of cancer at the molecular, cellular, and organism levels, thus providing the foundation for novel approaches in cancer prevention, detection, or treatment. Preclinical cancer research: Research involving laboratory or animal testing to determine the biological activity and safety of compounds or procedures that are intended to be applicable to the prevention, diagnosis, or treatment of cancer, or to the rehabilitation of the cancer patient. Clinical cancer research: Research investigating human subjects or materials and that

2 is directly applicable to the prevention, diagnosis, or treatment of cancer in the individual or group of individuals, or the rehabilitation of the patient. Epidemiologic cancer research: Research investigating the circumstances under which cancer occurs in populations by seeking to identify factors, including psychosocial and behavioral factors, that cause or are associated with risk for the development of cancer, or that promote prevention or control of cancer in populations. Health policy and health services cancer research: Research predicting or influencing the impact of social factors, financing systems, organizational structures and processes, legislation, health technologies, and personal behaviors on access to health care; quality and cost of healthcare; and on cancer outcome in individuals, families, communities, populations, organizations, and institutions. Psychosocial and behavioral cancer research: Research directed at understanding the effect(s) of individual, group, and/or socio-cultural processes on variables that affect cancer control across the continuum from the prevention and early detection of cancer to development, treatment, and progression of disease; the effect of interventions (including the interaction of biological factors with behavioral or social variables) on influencing change in individual, group, and/or socio-cultural processes that affect cancer outcome; and the predictors of or influences (including effects of disease and health care intervention) on quality of life of cancer patients and their caregivers. Health professional training: The Health Professional Training Grant Program is intended to ensure that an adequate number of highly qualified people enter careers in cancer prevention and control practice. Support is provided for nurses, doctors, and social workers to pursue training in outstanding programs that must meet high standards for excellence. What types of grants does the Society award? Extramural grants Research grants Seven major types of research grants were funded by the American Cancer Society in fiscal year 2013; each was carefully reviewed by a rigorous peer review system: 1. Research Scholar Grants (RSG) support research projects initiated by investigators in the first 6 years of their independent research careers, or research projects initiated

3 by investigators at any career stage in the areas of health policy and health services research. 2. Mentored Research Scholar Grants (MRSG) support mentored clinical or applied research by full-time junior faculty, typically within the first 4 years of their appointment, with the goal of helping them become independent investigators in clinical, cancer control and prevention, epidemiologic, psychosocial, behavioral, health services, or health policy research. 3. Clinical Research Professor (CRP) and Research Professor (RP) Awards support outstanding mid-career investigators who are making seminal contributions to basic or clinical cancer research. 4. Postdoctoral Fellowships (PF) support the training of researchers who recently received their doctorates. 5. Institutional Research Grants (IRG) are awarded to institutions as block grants to provide funding for independent junior faculty to initiate pilot research projects. Grantees from this program often go on to obtain larger grants. This results in the Society s return from every dollar investment into this program, which in 2010 meant realizing an approximate $42 million gain into the scientific community and potential cancer research advancements. 6. The Pilot and Exploratory Project Mechanism (PEP) is intended to provide support for a small pilot or exploratory project whose purpose is to test interventions, develop research methodologies, and explore novel areas. Health professional training grants American Cancer Society Health Professional Training Grants (HPTGs) are categorized into 4 types: 1. Cancer Control Career Development Awards for Primary Care Physicians (CCCDA) support primary care physicians with academic ranks from instructor to assistant professor pursuing a career with an emphasis on cancer control. 2. Scholarships in Cancer Nursing (SCN) support students pursuing master s degrees in oncology nursing or doctoral degrees in nursing or a related area. 3. Oncology Social Work Training Grants (SW) support the training of second-year master s degree students to provide psychosocial services to people with cancer and

4 their families, and the training of doctoral students to conduct oncology psychosocial research. 4. Physician Training Awards in Preventive Medicine (PTAPM) support physician training in accredited preventive medicine residency programs that provide cancer prevention and control research and practice opportunities. Intramural research The Epidemiology Research Program conducts and communicates high-quality epidemiologic research to advance our understanding of cancer causes, prevention, and survivorship and, thereby, saves lives from cancer. Go to to learn more about this program. The Surveillance and Health Services Research Program analyzes and disseminates population-based information on cancer occurrence, causes, prevention, and treatment to strengthen the scientific basis for cancer control nationally and globally. In addition to its own independent research, the group also collaborates with other surveillance and health services organizations nationally and internationally and provides scientific expertise to other components of the Society. Go to to learn more about this program. The Behavioral Research Centerconducts original behavioral and psychosocial research; facilitates the transfer of such research and theory to improve cancer control policies related to the prevention, detection, and treatment of cancer; and provides consultation to other parts of the Society. Go to to learn more about this program. The Statistics and Evaluation Centerprovides statistical, methodological, survey, and evaluative consulting services to the Society. It also publishes high quality mathematical, statistical, and survey methods research that allows more effective use of patient resources in cancer clinical trials and that result in transparent and validated models for accurately predicting cancer incidence and mortality. Go to to learn more about this program. The Economic & Health Policy Research Program conducts original research in international tobacco control, with a focus on the economics of tobacco control. Created

5 in 2006, as the International Tobacco Control Research Program, the Economic and Health Policy Research (EHPR) program conducts original and policy-relevant research with a particular emphasis on the economic aspects of tobacco control. EHPR is uniquely capable of translating complex economic concepts into tools for policy change. We build research capacity in low- and middle-income countries in order to generate local-specific research evidence. We are proud of our extensive collaboration with the top investigators and the top research institutions in this highly specialized field. See our web site at to learn more about the work being done by this research program When did the Society start its research program? The Society awarded its first external research grants in Intramural research began in the 1950s, when researchers at the Society first began estimating the number of new cancer cases and deaths and produced some of the first evidence linking tobacco smoking to lung cancer. Where does the Society do its research? The Intramural Research Department and its 6 constituent research programs are based at the American Cancer Society s National Home Office in Atlanta, Georgia. Most of the External Grants are used to fund researchers and institutions across the country. Why does the Society have a research program? In 1945, the American Cancer Society recognized that research held the ultimate answers to the prevention, diagnosis, and control of cancer, and so initiated the first non-governmental cancer research program in the United States. The Society s program is unique because the vast majority of our extramural research budget is dedicated to funding investigators at the beginning of their research careers. Strong emphasis is placed on the training and support of the next generation of cancer researchers, and the Society is able to move quickly to fund new ideas or whole new areas of research through our targeted research programs and research opportunity grants. How does the Society fund extramural research grants?

6 The Society funds grants using a process called external peer review which uses expert judgment and avoids conflicts of interest. It follows this process: Grant applications are ranked on the basis of merit by one of several disciplinespecific Peer Review Committees (PRCs), each of which is made up of 12 to 25 scientific advisors, or peers, who are experts in their fields. Each PRC also has one or more stakeholders as full voting members of the committee. These are people who have been personally touched by cancer and who have a keen personal interest in cancer research. The Council for Extramural Grants, a multidisciplinary committee of mid-level and senior scientists, as well as several stakeholders, approves funding based on the PRC reviews, the Society s mission, and the amount of money available. How much has the Society invested in research? Since 1946, the Society has invested more than $4.6 billion in research. The annual total research expenditure has grown from just over $1 million at its inception to more than $148 million today. Less than 5% of the Extramural Grants budget goes for operating expenses of the grant programs. How many lives have been saved through research? Since 1971, the number of cancer survivors alive today, more than 13 million, has more than tripled and the 5-year survivorship rate is now 67%. Much of this success can be attributed to research. The 2012 Annual Report to the Nation on the Status of Cancer reports that cancer incidence rates (both sexes combined, all sites combined) have stabilized despite population increases and the aging of the population. Cancer death rates have been declining since 1991 and are now decreasing at an average of 1.5% per year between 1999 and What are the results of our research program? Scientists supported by the American Cancer Society have made great contributions. For example, these scientists have: Established the link between cigarette smoking and lung cancer Demonstrated the effectiveness of the Papanicolaou (Pap) smear in detecting cervical cancer at an early stage, decreasing deaths by more than 70%

7 Developed cancer-fighting drugs (like 5-FU) and biologic response modifiers (such as interferon) Dramatically increased the cure rate for childhood leukemia to over 80% Developed monoclonal antibodies to treat lymphoma and breast cancer Shown the importance of estrogen receptors in breast cancer Shown the proficiency of the estrogen antagonist, tamoxifen, in preventing breast cancer recurrence and reducing incidence in high-risk women Proved the safety and effectiveness of mammograms Proved the efficacy of lumpectomy plus radiation compared with mastectomy for some breast cancers Created hormone therapy for prostate cancer Developed the prostate-specific antigen (PSA) screening test Defined the role of new blood vessels (angiogenesis) in tumor growth Defined the structure of DNA Discovered cancer-causing genes and tumor suppressor genes Discovered breast and colon cancer susceptibility genes Developed monoclonal antibodies to treat breast cancer (Herceptin ) and lymphoma (Rituxan ) Used small molecule inhibitors (such as Gleevec ) for treatment of chronic myeloid leukemia Developed antiangiogenesis drugs, such as Avastin, for the treatment of some cancers Used harmless viral particles in the development of cervical cancer vaccines, such as Gardasil The success of the Society s research program is exemplified by the fact that 47 Nobel Prize winners received grant support from the Society before they were awarded the prize. How do I find out about the Society s research program? Visit for more information about Intramural Research and Extramural Research. Investigators may download and print grant reporting forms, applications, and instructions at on the American Cancer Society s Web site.

8 For other information on Extramural Grants, call Cheri Richard at or her at American Cancer Society Research Programs The American Cancer Society dedicates more money to cancer research than any other private, not-for-profit, non-government funder of cancer research in the United States. The Society s research program has 7 components: Extramural Grants, and the 6 programs that make up Intramural Research: Epidemiology, Surveillance, International Tobacco Control, Health Services Research, the Behavioral Research Center, and the Statistics and Evaluation Center. Who does the Society give research dollars to? The Society is currently supporting investigators at more than 200 leading medical schools, universities, and research institutions across the nation. How does the Society define research? The American Cancer Society uses the following mutually exclusive definitions: Basic cancer research: Research seeking to answer fundamental questions about the nature of cancer, and that is directed towards understanding the mechanisms and concepts related to the development or prevention of cancer at the molecular, cellular, and organism levels, thus providing the foundation for novel approaches in cancer prevention, detection, or treatment. Preclinical cancer research: Research involving laboratory or animal testing to determine the biological activity and safety of compounds or procedures that are intended to be applicable to the prevention, diagnosis, or treatment of cancer, or to the rehabilitation of the cancer patient. Clinical cancer research: Research investigating human subjects or materials and that is directly applicable to the prevention, diagnosis, or treatment of cancer in the individual

9 or group of individuals, or the rehabilitation of the patient. Epidemiologic cancer research: Research investigating the circumstances under which cancer occurs in populations by seeking to identify factors, including psychosocial and behavioral factors, that cause or are associated with risk for the development of cancer, or that promote prevention or control of cancer in populations. Health policy and health services cancer research: Research predicting or influencing the impact of social factors, financing systems, organizational structures and processes, legislation, health technologies, and personal behaviors on access to health care; quality and cost of healthcare; and on cancer outcome in individuals, families, communities, populations, organizations, and institutions. Psychosocial and behavioral cancer research: Research directed at understanding the effect(s) of individual, group, and/or socio-cultural processes on variables that affect cancer control across the continuum from the prevention and early detection of cancer to development, treatment, and progression of disease; the effect of interventions (including the interaction of biological factors with behavioral or social variables) on influencing change in individual, group, and/or socio-cultural processes that affect cancer outcome; and the predictors of or influences (including effects of disease and health care intervention) on quality of life of cancer patients and their caregivers. Health professional training: The Health Professional Training Grant Program is intended to ensure that an adequate number of highly qualified people enter careers in cancer prevention and control practice. Support is provided for nurses, doctors, and social workers to pursue training in outstanding programs that must meet high standards for excellence. What types of grants the does the Society award? Extramural grants Research grants Seven major types of research grants were funded by the American Cancer Society in fiscal year 2012; each was carefully reviewed by a rigorous peer review system: 1. Research Scholar Grants (RSG) support research projects initiated by investigators in the first 6 years of their independent research careers, or research projects initiated by investigators at any career stage in the areas of health policy and health services

10 research. 2. Mentored Research Scholar Grants (MRSG) support mentored clinical or applied research by full-time junior faculty, typically within the first 4 years of their appointment, with the goal of helping them become independent investigators in clinical, cancer control and prevention, epidemiologic, psychosocial, behavioral, health services, or health policy research. 3. Clinical Research Professor (CRP) and Research Professor (RP) Awards support outstanding mid-career investigators who are making seminal contributions to basic or clinical cancer research. 4. Postdoctoral Fellowships (PF) support the training of researchers who recently received their doctorates. 5. Institutional Research Grants (IRG) are awarded to institutions as block grants to provide funding for independent junior faculty to initiate pilot research projects. Grantees from this program often go on to obtain larger grants. This results in the Society s return from every dollar investment into this program, which in 2010 meant realizing an approximate $42 million gain into the scientific community and potential cancer research advancements. 6. The Pilot and Exploratory Project Mechanism (PEP) is intended to provide support for a small pilot or exploratory project whose purpose is to test interventions, develop research methodologies, and explore novel areas. Health professional training grants American Cancer Society Health Professional Training Grants (HPTGs) are categorized into 4 types: 1. Cancer Control Career Development Awards for Primary Care Physicians (CCCDA) support primary care physicians with academic ranks from instructor to assistant professor pursuing a career with an emphasis on cancer control. 2. Scholarships in Cancer Nursing (SCN) support students pursuing master s degrees in oncology nursing or doctoral degrees in nursing or a related area. 3. Oncology Social Work Training Grants (SW) support the training of second-year master s degree students to provide psychosocial services to people with cancer and their families, and the training of doctoral students to conduct oncology psychosocial

11 research. 4. Physician Training Awards in Preventive Medicine (PTAPM) support physician training in accredited preventive medicine residency programs that provide cancer prevention and control research and practice opportunities. Intramural research The Epidemiology Research Program conducts and communicates high-quality epidemiologic research to advance our understanding of cancer causes, prevention, and survivorship and, thereby, saves lives from cancer. Go to to learn more about this program. The Surveillance Research Program analyzes and disseminates population-based information on cancer occurrence, causes, prevention, and treatment to strengthen the scientific basis for cancer control nationally and globally. Go to to learn more about this program. The Behavioral Research Centerconducts original behavioral and psychosocial research; facilitates the transfer of such research and theory to improve cancer control policies related to the prevention, detection, and treatment of cancer; and provides consultation to other parts of the Society. Go to to learn more about this program. The Statistics and Evaluation Centerprovides statistical, methodological, survey, and evaluative consulting services to the Society. It also publishes high quality mathematical, statistical, and survey methods research that allows more effective use of patient resources in cancer clinical trials and that result in transparent and validated models for accurately predicting cancer incidence and mortality. See our website to learn more about this program. The Health Services Research Program analyzes cancer treatment and outcomes using data collected by the National Cancer Database (NCDB, a joint project of the American College of Surgeons and the American Cancer Society), SEER, Medicare, and other administrative and registry databases. Research focuses on topics such as defining the role of health insurance in cancer disparities; examining the relationships between insurance status, race/ethnicity, and stage at time of cancer diagnosis; quality of care; and cancer outcomes. Visit

12 to learn more about this program. The International Tobacco Control Research Program conducts original research in international tobacco control, with a focus on the economics of tobacco control. This work is done in collaboration with national and international investigators and is intended to provide the evidence base needed for tobacco control in low- and middleincome countries. See to learn more about the work being done by this research program. When did the Society start its research program? The Society awarded its first external research grants in Intramural research began in the 1950s, when researchers at the Society first began estimating the number of new cancer cases and deaths and produced some of the first evidence linking tobacco smoking to lung cancer. Where does the Society do its research? The Intramural Research Department and its 6 constituent research programs are based at the American Cancer Society s National Home Office in Atlanta, Georgia. Most of the External Grants are used to fund researchers and institutions across the country. Why does the Society have a research program? In 1945, the American Cancer Society recognized that research held the ultimate answers to the prevention, diagnosis, and control of cancer, and so initiated the first non-governmental cancer research program in the United States. The Society s program is unique because the vast majority of our extramural research budget is dedicated to funding investigators at the beginning of their research careers. Strong emphasis is placed on the training and support of the next generation of cancer researchers, and the Society is able to move quickly to fund new ideas or whole new areas of research through our targeted research programs and research opportunity grants. How does the Society fund extramural research grants?

13 The Society funds grants using a process called external peer review which uses expert judgment and avoids conflicts of interest. It follows this process: Grant applications are ranked on the basis of merit by one of several disciplinespecific Peer Review Committees (PRCs), each of which is made up of 12 to 25 scientific advisors, or peers, who are experts in their fields. Each PRC also has one or more stakeholders as full voting members of the committee. These are people who have been personally touched by cancer and who have a keen personal interest in cancer research. The Council for Extramural Grants, a multidisciplinary committee of mid-level and senior scientists, as well as several stakeholders, approves funding based on the PRC reviews, the Society s mission, and the amount of money available. How much has the Society invested in research? Since 1946, the Society has invested over $4.6 billion in research. The annual total research expenditure has grown from just over $1 million at its inception to more than $148 million today. Less than 5% of the Extramural Grants budget goes for operating expenses of the grant programs. How many lives have been saved through research? Since 1971, the number of cancer survivors alive today, more than 13 million, has more than tripled and the 5-year survivorship rate is now 67%. Much of this success can be attributed to research. The 2012 Annual Report to the Nation on the Status of Cancer reports that cancer incidence rates (both sexes combined, all sites combined) have stabilized despite population increases and the aging of the population. Cancer death rates have been declining since 1991 and are now decreasing at an average of 1.5% per year between 1999 and What are the results of our research program? Scientists supported by the American Cancer Society have made great contributions. For example, these scientists have: Established the link between cigarette smoking and lung cancer Demonstrated the effectiveness of the Papanicolaou (Pap) smear in detecting cervical cancer at an early stage, decreasing deaths by more than 70%

14 Developed cancer-fighting drugs (like 5-FU) and biologic response modifiers (such as interferon) Dramatically increased the cure rate for childhood leukemia to over 80% Developed monoclonal antibodies to treat lymphoma and breast cancer Shown the importance of estrogen receptors in breast cancer Shown the proficiency of the estrogen antagonist, tamoxifen, in preventing breast cancer recurrence and reducing incidence in high-risk women Proved the safety and effectiveness of mammograms Proved the efficacy of lumpectomy plus radiation compared with mastectomy for some breast cancers Created hormone therapy for prostate cancer Developed the prostate-specific antigen (PSA) screening test Defined the role of new blood vessels (angiogenesis) in tumor growth Defined the structure of DNA Discovered cancer-causing genes and tumor suppressor genes Discovered breast and colon cancer susceptibility genes Developed monoclonal antibodies to treat breast cancer (Herceptin ) and lymphoma (Rituxan ) Used small molecule inhibitors (such as Gleevec ) for treatment of chronic myeloid leukemia Developed antiangiogenesis drugs, such as Avastin, for the treatment of some cancers Used harmless viral particles in the development of cervical cancer vaccines, such as Gardasil The success of the Society s research program is exemplified by the fact that 47 Nobel Prize winners received grant support from the Society before they were awarded the prize. How do I find out about the Society s research program? Investigators may download and print grant reporting forms, applications, and instructions from the American Cancer Society s Web site at ants/index. For information on Extramural Grants, call Cheri Richard at or her at cheri.richard@cancer.org.

15 More information about Intramural Research is available at American Cancer Society Research Programs The American Cancer Society dedicates more money to cancer research than any other private, not-for-profit, non-government funder of cancer research in the United States. The Society s research program has 6 components: Extramural Grants, and the 5 programs that make up Intramural Research: Epidemiology, Surveillance and Health Services Research, Econmic & Health Policy Research, the Behavioral Research Center, and the Statistics and Evaluation Center. Who does the Society give research dollars to? The Society is currently supporting investigators at more than 200 leading medical schools, universities, and research institutions across the nation. How does the Society define research? The American Cancer Society uses the following mutually exclusive definitions: Basic cancer research: Research seeking to answer fundamental questions about the nature of cancer, and that is directed towards understanding the mechanisms and concepts related to the development or prevention of cancer at the molecular, cellular, and organism levels, thus providing the foundation for novel approaches in cancer prevention, detection, or treatment. Preclinical cancer research: Research involving laboratory or animal testing to determine the biological activity and safety of compounds or procedures that are intended to be applicable to the prevention, diagnosis, or treatment of cancer, or to the rehabilitation of the cancer patient. Clinical cancer research: Research investigating human subjects or materials and that is directly applicable to the prevention, diagnosis, or treatment of cancer in the individual or group of individuals, or the rehabilitation of the patient. Epidemiologic cancer research: Research investigating the circumstances under

16 which cancer occurs in populations by seeking to identify factors, including psychosocial and behavioral factors, that cause or are associated with risk for the development of cancer, or that promote prevention or control of cancer in populations. Health policy and health services cancer research: Research predicting or influencing the impact of social factors, financing systems, organizational structures and processes, legislation, health technologies, and personal behaviors on access to health care; quality and cost of healthcare; and on cancer outcome in individuals, families, communities, populations, organizations, and institutions. Psychosocial and behavioral cancer research: Research directed at understanding the effect(s) of individual, group, and/or socio-cultural processes on variables that affect cancer control across the continuum from the prevention and early detection of cancer to development, treatment, and progression of disease; the effect of interventions (including the interaction of biological factors with behavioral or social variables) on influencing change in individual, group, and/or socio-cultural processes that affect cancer outcome; and the predictors of or influences (including effects of disease and health care intervention) on quality of life of cancer patients and their caregivers. Health professional training: The Health Professional Training Grant Program is intended to ensure that an adequate number of highly qualified people enter careers in cancer prevention and control practice. Support is provided for nurses, doctors, and social workers to pursue training in outstanding programs that must meet high standards for excellence. What types of grants does the Society award? Extramural grants Research grants Seven major types of research grants were funded by the American Cancer Society in fiscal year 2013; each was carefully reviewed by a rigorous peer review system: 1. Research Scholar Grants (RSG) support research projects initiated by investigators in the first 6 years of their independent research careers, or research projects initiated by investigators at any career stage in the areas of health policy and health services research. 2. Mentored Research Scholar Grants (MRSG) support mentored clinical or applied

17 research by full-time junior faculty, typically within the first 4 years of their appointment, with the goal of helping them become independent investigators in clinical, cancer control and prevention, epidemiologic, psychosocial, behavioral, health services, or health policy research. 3. Clinical Research Professor (CRP) and Research Professor (RP) Awards support outstanding mid-career investigators who are making seminal contributions to basic or clinical cancer research. 4. Postdoctoral Fellowships (PF) support the training of researchers who recently received their doctorates. 5. Institutional Research Grants (IRG) are awarded to institutions as block grants to provide funding for independent junior faculty to initiate pilot research projects. Grantees from this program often go on to obtain larger grants. This results in the Society s return from every dollar investment into this program, which in 2010 meant realizing an approximate $42 million gain into the scientific community and potential cancer research advancements. 6. The Pilot and Exploratory Project Mechanism (PEP) is intended to provide support for a small pilot or exploratory project whose purpose is to test interventions, develop research methodologies, and explore novel areas. Health professional training grants American Cancer Society Health Professional Training Grants (HPTGs) are categorized into 4 types: 1. Cancer Control Career Development Awards for Primary Care Physicians (CCCDA) support primary care physicians with academic ranks from instructor to assistant professor pursuing a career with an emphasis on cancer control. 2. Scholarships in Cancer Nursing (SCN) support students pursuing master s degrees in oncology nursing or doctoral degrees in nursing or a related area. 3. Oncology Social Work Training Grants (SW) support the training of second-year master s degree students to provide psychosocial services to people with cancer and their families, and the training of doctoral students to conduct oncology psychosocial research. 4. Physician Training Awards in Preventive Medicine (PTAPM) support physician

18 training in accredited preventive medicine residency programs that provide cancer prevention and control research and practice opportunities. Intramural research The Epidemiology Research Program conducts and communicates high-quality epidemiologic research to advance our understanding of cancer causes, prevention, and survivorship and, thereby, saves lives from cancer. Go to to learn more about this program. The Surveillance and Health Services Research Program analyzes and disseminates population-based information on cancer occurrence, causes, prevention, and treatment to strengthen the scientific basis for cancer control nationally and globally. In addition to its own independent research, the group also collaborates with other surveillance and health services organizations nationally and internationally and provides scientific expertise to other components of the Society. Go to to learn more about this program. The Behavioral Research Centerconducts original behavioral and psychosocial research; facilitates the transfer of such research and theory to improve cancer control policies related to the prevention, detection, and treatment of cancer; and provides consultation to other parts of the Society. Go to to learn more about this program. The Statistics and Evaluation Centerprovides statistical, methodological, survey, and evaluative consulting services to the Society. It also publishes high quality mathematical, statistical, and survey methods research that allows more effective use of patient resources in cancer clinical trials and that result in transparent and validated models for accurately predicting cancer incidence and mortality. Go to to learn more about this program. The Economic & Health Policy Research Program conducts original research in international tobacco control, with a focus on the economics of tobacco control. Created in 2006, as the International tobacco Control Research Program, the Economic and Health Policy Research (EHPR) program conducts original and policy-relevant research with a particular emphasis on the economic aspects of tobacco control. EHPR is uniquely capable of trnaslating complex economic concepts into tools for policy change.

19 We build research capacity in low- and middle-income countries in order to generate local-specific research evidence. We are proud of our extensive collaboration with the top investigators and the top research institutions in this highly specialized field. See our web site at to learn more about the work being done by this research program When did the Society start its research program? The Society awarded its first external research grants in Intramural research began in the 1950s, when researchers at the Society first began estimating the number of new cancer cases and deaths and produced some of the first evidence linking tobacco smoking to lung cancer. Where does the Society do its research? The Intramural Research Department and its 6 constituent research programs are based at the American Cancer Society s National Home Office in Atlanta, Georgia. Most of the External Grants are used to fund researchers and institutions across the country. Why does the Society have a research program? In 1945, the American Cancer Society recognized that research held the ultimate answers to the prevention, diagnosis, and control of cancer, and so initiated the first non-governmental cancer research program in the United States. The Society s program is unique because the vast majority of our extramural research budget is dedicated to funding investigators at the beginning of their research careers. Strong emphasis is placed on the training and support of the next generation of cancer researchers, and the Society is able to move quickly to fund new ideas or whole new areas of research through our targeted research programs and research opportunity grants. How does the Society fund extramural research grants? The Society funds grants using a process called external peer review which uses expert judgment and avoids conflicts of interest. It follows this process:

20 Grant applications are ranked on the basis of merit by one of several disciplinespecific Peer Review Committees (PRCs), each of which is made up of 12 to 25 scientific advisors, or peers, who are experts in their fields. Each PRC also has one or more stakeholders as full voting members of the committee. These are people who have been personally touched by cancer and who have a keen personal interest in cancer research. The Council for Extramural Grants, a multidisciplinary committee of mid-level and senior scientists, as well as several stakeholders, approves funding based on the PRC reviews, the Society s mission, and the amount of money available. How much has the Society invested in research? Since 1946, the Society has invested more than $4.6 billion in research. The annual total research expenditure has grown from just over $1 million at its inception to more than $148 million today. Less than 5% of the Extramural Grants budget goes for operating expenses of the grant programs. How many lives have been saved through research? Since 1971, the number of cancer survivors alive today, more than 13 million, has more than tripled and the 5-year survivorship rate is now 67%. Much of this success can be attributed to research. The 2012 Annual Report to the Nation on the Status of Cancer reports that cancer incidence rates (both sexes combined, all sites combined) have stabilized despite population increases and the aging of the population. Cancer death rates have been declining since 1991 and are now decreasing at an average of 1.5% per year between 1999 and What are the results of our research program? Scientists supported by the American Cancer Society have made great contributions. For example, these scientists have: Established the link between cigarette smoking and lung cancer Demonstrated the effectiveness of the Papanicolaou (Pap) smear in detecting cervical cancer at an early stage, decreasing deaths by more than 70% Developed cancer-fighting drugs (like 5-FU) and biologic response modifiers (such as interferon)

21 Dramatically increased the cure rate for childhood leukemia to over 80% Developed monoclonal antibodies to treat lymphoma and breast cancer Shown the importance of estrogen receptors in breast cancer Shown the proficiency of the estrogen antagonist, tamoxifen, in preventing breast cancer recurrence and reducing incidence in high-risk women Proved the safety and effectiveness of mammograms Proved the efficacy of lumpectomy plus radiation compared with mastectomy for some breast cancers Created hormone therapy for prostate cancer Developed the prostate-specific antigen (PSA) screening test Defined the role of new blood vessels (angiogenesis) in tumor growth Defined the structure of DNA Discovered cancer-causing genes and tumor suppressor genes Discovered breast and colon cancer susceptibility genes Developed monoclonal antibodies to treat breast cancer (Herceptin ) and lymphoma (Rituxan ) Used small molecule inhibitors (such as Gleevec ) for treatment of chronic myeloid leukemia Developed antiangiogenesis drugs, such as Avastin, for the treatment of some cancers Used harmless viral particles in the development of cervical cancer vaccines, such as Gardasil The success of the Society s research program is exemplified by the fact that 47 Nobel Prize winners received grant support from the Society before they were awarded the prize. How do I find out about the Society s research program? Visit for more information about Intramural Research and Extramural Research. Investigators may download and print grant reporting forms, applications, and instructions at on the American Cancer Society s Web site. For other information on Extramural Grants, call Cheri Richard at or her at cheri.richard@cancer.org.

22 Last Medical Review: 11/23/2017 Last Revised: 11/29/ Copyright American Cancer Society

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