Urinary Bladder: WHO Classification and AJCC Staging Update 2017
|
|
- Toby Lesley Robinson
- 6 years ago
- Views:
Transcription
1 Urinary Bladder: WHO Classification and AJCC Staging Update 2017 Houston Society of Clinical Pathologists 58 th Annual Spring Symposium Houston, TX April 8, 2017 Jesse K. McKenney, MD
2
3
4 Classification Overview Early papillary lesions Variants Plasmacytoid Nested Microcystic Micropapillary Staging scenarios pt1 Urethra Diverticula
5 Classification of Urothelial Neoplasia
6 Bladder Neoplasia: WHO 2016 Papillary Papilloma PUNLMP Low Grade CA High Grade CA Flat Lesions with Atypia Reactive Atypia Atypia UMP/Dysplasia Carcinoma in situ High Grade CA
7 Bladder Neoplasia: WHO 2016 Flat Hyperplasia? Papillary Hyperplasia (Atypia)? Early / Incipient Lesions?
8 Urothelial Proliferation of Uncertain Malignant Potential
9 Urothelial Proliferation of Uncertain Malignant Potential
10 Urothelial Proliferation of Uncertain Malignant Potential
11 Urothelial Proliferation of Uncertain Malignant Potential
12 NOT Urothelial Proliferation of Uncertain Malignant Potential
13 NOT Urothelial Proliferation of Uncertain Malignant Potential
14 Variants of Invasive Urothelial Carcinoma
15
16
17 Plasmacytoid Carcinoma Recognition Inflammatory cells Gastric and breast cancer Prognosis Poor response to chemotherapy Unusual patterns of disease failure
18 Plasmacytoid Carcinoma
19 Plasmacytoid Carcinoma
20 Plasmacytoid Carcinoma
21 Plasmacytoid Carcinoma
22 Plasmacytoid Carcinoma Cytokeratin AE1/3
23 Plasmacytoid Rhabdoid
24 Plasmacytoid Carcinoma: Presence of Signet Ring-Like Cells
25 Plasmacytoid Carcinoma Signet-ring Adenocarcinoma
26
27 Saphir O. Am J Pathol 1955; 31:223-31
28 Saphir O. Am J Pathol 1955; 31:223-31
29
30 Plasmacytoid Carcinoma in Peri-Ureteral Tissue Plasmacytoid Carcinoma: Presence of Signet Ring-Like Cells
31 WHO 2016 Criteria Plasmacytoid Carcinoma NO extracellular mucin Similar to diffuse type gastric CA or lobular breast CA Mucinous AdenoCA with Signet-Ring Cells Extracellular mucin Similar to mucinous adenoca of colon
32 Saphir O. Am J Pathol 1955; 31:223-31
33
34 Peritoneal spread common Bowel serosa and mesentery Ovary Peritoneal carcinomatosis Malignant effusions (pleural)
35 Plasmacytoid Carcinoma: Peritoneal Spread
36 Plasmacytoid Carcinoma in Peri-Ureteral Tissue
37 Plasmacytoid Carcinoma in Peri-Ureteral Tissue
38 Plasmacytoid Carcinoma in Peri-Prostatic Tissue
39 Plasmacytoid Carcinoma in Lymph Node Cytokeratin AE1/3
40 Plasmacytoid Carcinoma Differential Diagnosis Metastatic carcinomas to bladder? Lobular breast Diffuse type gastric Hematopoietic
41 Urothelial Carcinoma with Plasmacytoid Features GATA-3 Lobular breast CA: GATA-3
42 GATA-3 Positive Urothelial CA Breast CA T-lymphocyte subset Salivary gland CA Paraganglioma Parathyroid Subset of squamous cell CA Prostatic basal cells (patchy) GYN tract urothelial neoplasia
43 Gastric Carcinoma Met to Bladder Stomach Urinary bladder
44 Immunohistochemical Differential Mammaglobin Type GATA3 S100p CK7 CK20 ER PR CD138 P63 Urothelial Gastric Breast
45 Invasive urothelial carcinomas. Deceptively benign and Under-diagnosed
46
47 Invasive Urothelial Carcinoma: Nested Variant
48 Invasive Urothelial Carcinoma: Nested Variant
49 Invasive Urothelial Carcinoma: Nested Variant
50 Invasive Urothelial Carcinoma: Nested Variant
51 Invasive Urothelial Carcinoma: Nested Variant
52 Invasive Urothelial Carcinoma: Nested Variant Cytology
53 Invasive Florid Von urothelial Brunn s carcinoma, nest proliferation nested variant?
54 Nested Variant with Lymph Node Met
55 Invasive Urothelial Carcinoma: Large Nested
56 Invasive Urothelial Carcinoma: Large Nested
57 Invasive Urothelial Carcinoma: Large Nested
58 Invasive Urothelial Carcinoma: Large Nested
59
60 Invasive Urothelial Carcinoma: Microcystic Variant
61 Invasive Urothelial Carcinoma: Microcystic Variant
62 Invasive Urothelial Carcinoma: Microcystic Variant
63 Invasive Urothelial Carcinoma: Microcystic Variant
64 Invasive Urothelial Carcinoma: Microcystic Variant
65 Invasive Urothelial Carcinoma: Microcystic Variant
66 Invasive Urothelial Carcinoma: Microcystic Variant
67 Invasive Urothelial Carcinoma: Microcystic Variant
68 Deceptively Bland Carcinomas: Nested and Microcystic Prognosis Stage-for-stage behaves as aggressively as a high-grade carcinoma
69 Deceptively Bland Carcinomas Differential Diagnosis Nephrogenic adenoma von Brunn nests Inverted/Endophytic Urothelial Neoplasia
70 Deceptively Bland Carcinoma Nested Benign Mimics of Carcinoma Von Brunn s nests (ureter; renal pelvis) Urothelium Lamina Propria Muscularis Propria Tubular Microcystic Nephrogenic adenoma Von Brunn s nests (bladder)
71
72 Slender, delicate filiform processes or tight papillary clusters reminiscent of papillary serous carcinoma of ovary
73 Bladder Micropapillary CA Ovarian Serous Carcinoma
74 Invasive Micropapillary Carcinoma in Muscularis Propria
75 Invasive Micropapillary Carcinoma with LVI
76 Lymph Node Metastasis
77 Therapeutic Significance: On TURBT IF: pt1 (no invasion of muscularis propria) AND: micropapillary morphology THEN: suggest re-staging biopsies
78 J Urol 2006; 175:
79 Micropapillary Carcinoma: Cystectomy for pta and pt1 Disease? Pathologic assessment Extent of micropapillary component? Definition of non-invasive micropapillary? Definition of invasive micropapillary? Kamat, Gee, Dinney et al. J Urol 2006;175: Kamat, Dinney, Gee et al. Cancer 2007;110:62-67.
80 When does typical urothelial carcinoma become micropapillary?
81
82 Recommended Restricted Criteria Major feature 1 Multiple small nests in same lacunar space Frequently seen features 1 Epithelial ring forms 2 Back to back lacunae 3 Peripheral nuclei 4 Cytoplasmic vacuolization
83 Features Suggesting NOT Micropapillary Major features 1 Large nests (> 5 cells across narrowest width) 2 Epithelial confluence and branching
84 Back-to-Back Lacunae Multiple Nests in Same Lacunar Space
85 Epithelial Ring Forms Back-to-Back Lacunae
86 Intracytoplasmic Vacuoles
87 NOT Classic Micropapillary
88 NOT Classic Micropapillary
89 NOT Classic Micropapillary
90 Not Classic Micropapillary, But What Is It?
91 Urothelial CA with Distinct Mixed Features: Quantitative Problem 99% 1%
92 Even small foci of micropapillary differentiation portend a poor prognosis: report %
93
94 Micropapillary 96% Usual UC with Retrxn 63% MUC-1 33% 13% CA % 8% Her2/neu Sangoi et al. Mod Pathol 2009; 22:660
95
96 Non-invasive Micropapillary Carcinoma (pta) Included in studies proposing immediate surgery Criteria problems Qualitative threshold Definition? Quantitative threshold Glandular (villoglandular) differentiation
97 Non-Invasive Papillary Urothelial Carcinoma, Micropapillary
98 Non-Invasive Papillary Urothelial Carcinoma Does Cribriform = Micropapillary?
99 Non-Invasive Papillary Urothelial Carcinoma Micropapillary or Villoglandular/Glandular?
100 Clinical outcome is similar to other noninvasive high-grade urothelial carcinomas
101 WHO 2016 If these processes (micropapillary) are only present in the non-invasive component, the tumor should NOT be classified as micropapillary carcinoma
102 Micropapillary Reporting Recommendation 1. Use restrictive criteria for invasive micropapillary carcinoma 2. Report presence of ANY invasive micropapillary component and give percentage 3. Per WHO: do NOT diagnosis pta carcinoma using micropapillary term
103 BLADDER STAGING
104
105 Substaging in TUR pt1 Probably important! Not standardized Not recommended by consensus groups
106 Invasion of Prostatic Stroma: Which Route?
107 Invasion of Prostatic Stroma (pt4) pt2 pt3 Bladder pt4 Urethral pt2 Prostate
108 Staging in Bladder Diverticula
109 Classification Summary Early papillary lesions Variants Plasmacytoid Nested Microcystic Micropapillary Staging scenarios pt1 Urethra Diverticula
110 Urinary Bladder: WHO Classification and AJCC Staging Update 2017 Jesse K. McKenney, MD
4/12/2018. MUSC Pathology Symposium Kiawah Island April 18, Jesse K. McKenney, MD
MUSC Pathology Symposium Kiawah Island April 18, 2018 Jesse K. McKenney, MD 1 Urothelial Carcinoma with Alternative Differentiation 2 Urothelial Carcinoma with Alternative Differentiation Recognition as
More informationBLADDER CANCER EPIDEMIOLOGY
BLADDER CANCER WHAT IS NEW AND CLINICALLY RELEVANT Canadian Geese - Geist Reservoir (my backyard), Indianapolis, USA BLADDER CANCER EPIDEMIOLOGY Urinary bladder 17,960 2% Urinary bladder 4,390 1.6% Siegel
More informationACCME/Disclosures. Case History 4/13/2016. USCAP GU Specialty Conference Case 3. Ann Arbor, MI
USCAP GU Specialty Conference Case 3 March 2016 L. Priya Kunju, M.D. University of Michigan Health System Ann Arbor, MI University of Michigan Health System ACCME/Disclosures The USCAP requires that anyone
More informationUpdate on Bladder Cancer: What s New in the 2016 WHO Classification of Bladder Tumors and 8 th Edition of AJCC Staging Manual
Update on Bladder Cancer: What s New in the 2016 WHO Classification of Bladder Tumors and 8 th Edition of AJCC Staging Manual Rajal B. Shah, M.D. Director, Urologic Pathology SHAHR6@ccf.org @rajalbshah
More informationUnknown Slides Conference
Unknown Slides Conference Jae Y. Ro, MD, PhD Weill Medical College of Cornell Univ. The Methodist Hospital, and UT MD Anderson Cancer Center Houston, TX November 9, 2013 Amman, Jordan 25 th Congress of
More informationUnusual Variants of Bladder Cancer Cristina Magi-Galluzzi, MD, PhD
Unusual Variants of Bladder Cancer Cristina Magi-Galluzzi, MD, PhD Director of Genitourinary Pathology, Professor of Pathology, Lerner College of Medicine Cleveland Clinic Objectives Update on variants
More information5/21/2018. Prostate Adenocarcinoma vs. Urothelial Carcinoma. Common Differential Diagnoses in Urological Pathology. Jonathan I.
Common Differential Diagnoses in Urological Pathology Jonathan I. Epstein Prostate Adenocarcinoma vs. Urothelial Carcinoma 1 2 NKX3.1 NKX3.1 3 4 5 6 Proposed ISUP Recommendations Option to use PSA as a
More informationSynonyms. Nephrogenic metaplasia Mesonephric adenoma
Nephrogenic Adenoma Synonyms Nephrogenic metaplasia Mesonephric adenoma Definition Benign epithelial lesion of urinary tract with tubular, glandular, papillary growth pattern Most frequently in the urinary
More informationJesse K. McKenney, MD
Jesse K. McKenney, MD Outline Microscopic anatomy of the urinary bladder Diagnosing invasion Subtle patterns (variants) of carcinoma Clinically important variants of carcinoma Microanatomy of Bladder Initial
More informationBladder Case 1 SURGICAL PATHOLOGY REPORT. Procedure: Cystoscopy, transurethral resection of bladder tumor (TURBT)
Bladder Case 1 February 17, 2007 Specimen (s) received: Bladder Tumor Pre-operative Diagnosis: Bladder Cancer Post operative Diagnosis: Bladder Cancer Procedure: Cystoscopy, transurethral resection of
More informationUrothelial carcinoma is the most common tumor in the
Micropapillary Variant of Urothelial Carcinoma in the Upper Urinary Tract A Clinicopathologic Study of 11 Cases Charles C. Guo, MD; Pheroze Tamboli, MD; Bogdan Czerniak, MD, PhD Context. Micropapillary
More informationCarcinoma of the Urinary Bladder Histopathology
Carcinoma of the Urinary Bladder Histopathology Reporting Proforma (Radical & Partial Cystectomy, Cystoprostatectomy) Includes the International Collaboration on Cancer reporting dataset denoted by * Family
More informationA215- Urinary bladder cancer tissues
A215- Urinary bladder cancer tissues (formalin fixed) For research use only Specifications: No. of cases: 45 Tissue type: Urinary bladder cancer tissues No. of spots: 2 spots from each cancer case (90
More informationThe pathology of bladder cancer
1 The pathology of bladder cancer Charles Jameson Introduction Carcinoma of the bladder is the seventh most common cancer worldwide [1]. It comprises 3.2% of all cancers, with an estimated 260 000 new
More informationIndex 179. Genital tract contaminants, 17, 20, 22, 150 papilloma virus-infected cells, 47 squamous cells, sources of, 7
Index Accuracy of urinary cytology, 166 Acute inflammatory cells, 38 catheter sample, 39 herpes simplex infections, 44 carcinomas, 104, 105 non-viral inclusions, 52, 53 voided urine, 17 Adenocarcinoma
More informationUpdates in Urologic Pathology WHO Made Those Changes?! Peyman Tavassoli Pathology Department BC Cancer Agency
Updates in Urologic Pathology WHO Made Those Changes?! Peyman Tavassoli Pathology Department BC Cancer Agency World Health Organization Available in Feb 2016 Frame work for reporting Major contributing
More informationKidney, Bladder and Prostate Neoplasia. David Bingham MD
Kidney, Bladder and Prostate Neoplasia David Bingham MD typical malignant cytology of bladder washings 1 benign 2 malignant typical malignant cytology of bladder washings b Bladder tumor Non invasive papillary
More informationCondyloma Acuminatum. Mimics of Bladder Cancer. Squamous Papilloma. Squamous epithelium in bladder
Mimics of Bladder Cancer Murali Varma Cardiff, UK wptmv@cf.ac.uk Squamous epithelium in bladder Non-keratinising vaginal type mucosa common in trigone region in women Normal variant Sarajevo Nov 2013 Squamous
More informationMicrocystic transitional cell carcinoma: a rare tumor of the urinary bladder
PATHOLOGICA 2017;109:151-155 Case report Microcystic transitional cell carcinoma: a rare tumor of the urinary bladder M. TRIKI 1, L. AYADI 1, R. KALLEL 1, S. CHARFI 1, I. SAGUEM 1, N. MHIRI 2, T.S. BOUDAWARA
More informationUpdate on bladder neoplasia: 2016 WHO classification and recent developments within the pathologic, molecular & clinical domains of the disease
Update on bladder neoplasia: 2016 WHO classification and recent developments within the pathologic, molecular & clinical domains of the disease Biology of urothelial tumorigenesis: insights from genetically
More informationGUIDELINES ON NON-MUSCLE- INVASIVE BLADDER CANCER
GUIDELINES ON NON-MUSCLE- INVASIVE BLADDER CANCER (Limited text update December 21) M. Babjuk, W. Oosterlinck, R. Sylvester, E. Kaasinen, A. Böhle, J. Palou, M. Rouprêt Eur Urol 211 Apr;59(4):584-94 Introduction
More informationMody. AIS vs. Invasive Adenocarcinoma of the Cervix
Common Problems in Gynecologic Pathology Michael T. Deavers, M.D. Houston Methodist Hospital, Houston, Texas Common Problems in Gynecologic Pathology Adenocarcinoma in-situ (AIS) of the Cervix vs. Invasive
More informationLow-grade serous neoplasia. Robert A. Soslow, MD
Low-grade serous neoplasia Robert A. Soslow, MD soslowr@mskcc.org Outline Orientation Ovarian tumor overview Non serous borderline tumors Serous borderline tumors Clinical summary Morphologic description
More information2007 Multiple Primary and
2007 Multiple Primary and Histology Coding Rules Beyond the Basics Florida Cancer Data System Annual Conference Tampa, FL July 26,2007 Steven Peace, CTR Westat Carol Johnson, CTR NCI SEER Peggy Adamo,
More informationCase 3 - GYN. History: 66 year old, routine Pap test. Dr. Stelow
Case 3 - GYN History: 66 year old, routine Pap test Dr. Stelow Case 3 66 year year old woman Routine Pap Test Cytologic Features 3 dimensional clusters of cells with small to moderate amount of
More informationProstate Pathology: Prostate Carcinoma, variants and Gleason Grading (Part 1)
Prostate Pathology: Prostate Carcinoma, variants and Gleason Grading (Part 1) Jae Y. Ro, MD, PhD June 7, 2012 Ten Leading Cancer Types for the Estimated New Cancer Cases and Deaths By Sex, United States,
More informationQ&A. Fabulous Prizes. Collecting Cancer Data: Bladder, Renal Pelvis, and Ureter 5/2/13. NAACCR Webinar Series
Collecting Cancer Data Bladder & Renal Pelvis NAACCR 2012 2013 Webinar Series Q&A Please submit all questions concerning webinar content through the Q&A panel. Reminder: If you have participants watching
More informationBasement membrane in lobule.
Bahram Memar, MD Basement membrane in lobule. Normal lobule-luteal phase Normal lobule-follicular phase Lactating breast Greater than 95% are adenocarcinomas in situ carcinomas and invasive carcinomas.
More informationPatient identifiers Date of request Accession/Laboratory number. TUMOUR FOCALITY (Note 4) (Note 3)
Carcinoma of the Bladder Histopathology Reporting Guide Cystectomy, Cystoprostatectomy and Diverticulectomy Specimen Family/Last name Given name(s) Date of birth DD MM YYYY Patient identifiers Date of
More informationINTRADUCTAL LESIONS OF THE PROSTATE. Jonathan I. Epstein
INTRADUCTAL LESIONS OF THE PROSTATE Jonathan I. Epstein Topics Prostatic intraepithelial neoplasia (PIN) Intraductal adenocarcinoma (IDC-P) Intraductal urothelial carcinoma Ductal adenocarcinoma High Prostatic
More informationCarcinoma of the Renal Pelvis and Ureter Histopathology
Carcinoma of the Renal Pelvis and Ureter Histopathology Reporting Proforma (NEPHROURETERECTOMY AND URETERECTOMY) Includes the International Collaboration on Cancer reporting dataset denoted by * Family
More informationBreast cancer: IHC classification. Mogens Vyberg Professor of Clinical Pathology Director of NordiQC Aalborg University Hospital, Aalborg, Denmark
Breast cancer: IHC classification Mogens Vyberg Professor of Clinical Pathology Director of NordiQC Aalborg University Hospital, Aalborg, Denmark http://upload.wikimedia.org/wikipedia/commons/1/1a/breast.svg
More informationCoordinate Expression of Cytokeratins 7 and 20 in Prostate Adenocarcinoma and Bladder Urothelial Carcinoma
Anatomic Pathology / CYTOKERATINS 7 AND 20 IN PROSTATE AND BLADDER CARCINOMAS Coordinate Expression of Cytokeratins 7 and 20 in Prostate Adenocarcinoma and Bladder Urothelial Carcinoma Nader H. Bassily,
More informationJoseph Misdraji, M.D. GI pathology Unit Massachusetts General Hospital
Joseph Misdraji, M.D. GI pathology Unit Massachusetts General Hospital jmisdraji@partners.org Low-grade appendiceal mucinous neoplasm (LAMN) High-grade appendiceal mucinous neoplasm (HAMN) Adenocarcinoma
More informationMorphologic diversity in urothelial carcinoma; pathological and clinical correlates
Morphologic diversity in urothelial carcinoma; pathological and clinical correlates Victor E. Reuter, M.D. Memorial Sloan Kettering Cancer Center A Practical Approach to Genitourinary Pathology Firenze,
More informationEpithelial tumors. Dr. F.F. Khuzin, PhD Dr. M.O. Mavlikeev
Epithelial tumors Dr. F.F. Khuzin, PhD Dr. M.O. Mavlikeev Epithelial tumors Tumors from the epithelium are the most frequent among tumors. There are 2 group features of these tumors: The presence in most
More informationUrinary Bladder, Ureter, and Renal Pelvis
Urinary Bladder, Ureter, and Renal Pelvis Protocol applies to all carcinomas of the urinary bladder, ureter, and renal pelvis. Protocol revision date: January 2005 Based on AJCC/UICC TNM, 6th edition Procedures
More informationList of Available TMAs in the PRN
TMA RPCI_BrainCa01 RPCI_BrCa03 RPCI_BrCa04 RPCI_BrCa05 RPCI_BrCa0 RPCI_BrCa07 RPCI_BrCa08 RPCI_BrCa15 RPCI_BrCa1 RPCI_BrCa17 RPCI_BrCa18 RPCI_BrCa19 RPCI_BrCa20 RPCI_BrCa21 RPCI_BrCa24 RPCI_BrCa25 RPCI_BrCa2
More informationSalivary Glands 3/7/2017
Salivary Glands 3/7/2017 Goals and objectives Focus on the entities unique to H&N Common board type facts Information for your future practice Salivary Glands Salivary Glands Major gland. Paratid. Submandibular.
More informationGOBLET CELL CARCINOID. Hanlin L. Wang, MD, PhD University of California Los Angeles
GOBLET CELL CARCINOID Hanlin L. Wang, MD, PhD University of California Los Angeles Disclosure of Relevant Financial Relationships USCAP requires that all planners (Education Committee) in a position to
More informationGOBLET CELL CARCINOID
GOBLET CELL CARCINOID Hanlin L. Wang, MD, PhD University of California Los Angeles Disclosure of Relevant Financial Relationships USCAP requires that all planners (Education Committee) in a position to
More informationAnkur R Sangoi 1, John P Higgins 1, Robert V Rouse 1,2, Anne G Schneider 3 and Jesse K McKenney 1,3,4, *
& 2009 USCAP, Inc All rights reserved 0893-3952/09 $32.00 www.modernpathology.org Immunohistochemical comparison of MUC1, CA125, and Her2Neu in invasive micropapillary carcinoma of the urinary tract and
More informationPSA. HMCK, p63, Racemase. HMCK, p63, Racemase
Case 1 67 year old male presented with gross hematuria H/o acute prostatitis & BPH Urethroscopy: small, polypoid growth with a broad base emanating from the left side of the verumontanum Serum PSA :7 ng/ml
More informationSEER Summary Stage Still Here!
SEER Summary Stage Still Here! CCRA NORTHERN REGION STAGING SYMPOSIUM SEPTEMBER 20, 2017 SEER Summary Stage Timeframe: includes all information available through completion of surgery(ies) in the first
More informationUrinary Bladder, Ureter, and Renal Pelvis
Urinary Bladder, Ureter, and Renal Pelvis Protocol applies to all carcinomas of the urinary bladder, ureter, and renal pelvis. Protocol revision date: January 2005 Based on AJCC/UICC TNM, 6th edition Procedures
More informationPapillary Lesions of the Breast: WHO Update
Papillary Lesions of the Breast: WHO Update Stuart J. Schnitt, M.D. Department of Pathology Beth Israel Deaconess Medical Center and Harvard Medical School Boston, MA, USA Papillary Lesions of the Breast
More informationGross appearance of nodular hyperplasia in material obtained from suprapubic prostatectomy. Note the multinodular appearance and the admixture of
Tiền liệt tuyến Tiền liệt tuyến Gross appearance of nodular hyperplasia in material obtained from suprapubic prostatectomy. Note the multinodular appearance and the admixture of solid and microcystic areas.
More informationThey Do Look Alike : Mimics of Prostate Cancer in Biopsy Samples
They Do Look Alike : in Biopsy Samples Gladell P. Paner, MD Departments of Pathology and Surgery (Urology) University of Chicago, IL USA Gladell.paner@uchospitals.edu Benign in Needle Biopsy 1. Benign
More informationPathology of the Prostate. PathoBasic Tatjana Vlajnic
Pathology of the Prostate PathoBasic 24.01.17 Tatjana Vlajnic Overview Adenocarcinoma of the prostate Grading Special variants Mimickers of prostate adenocarcinoma Atrophy Inflammatory conditions Granulomatous
More informationRecent advances in breast cancers
Recent advances in breast cancers Breast cancer is a hetrogenous disease due to distinct genetic alterations. Similar morphological subtypes show variation in clinical behaviour especially in response
More informationUpdate on staging colorectal carcinoma, the 8 th edition AJCC. General overview of staging. When is staging required? 11/1/2017
Update on staging colorectal carcinoma, the 8 th edition AJCC Dale C. Snover, MD November 3, 2017 General overview of staging Reason for uniform staging Requirements to use AJCC manual and/or CAP protocols
More informationImmunohistochemistry and Bladder Tumours
Immunohistochemistry and Bladder Tumours Dr. Andrew J. Evans MD PhD FRCPC Consultant in Genitourinary Pathology University Health Network Toronto, ON Objec ves Review markers of urothelial differen a on
More informationComparative Analysis of Stage and Other Prognostic Factors Among Urethral, Ureteral, and Renal Pelvis Malignant Tumors
Comparative Analysis of Stage and Other Prognostic Factors Among Urethral, Ureteral, and Renal Pelvis Malignant Tumors Presented to NAACCR Annual Conference 2012 Serban Negoita, MD, DrPH; Marsha Dunn,
More informationPRELIMINARY CYTOLOGIC DIAGNOSIS: Suspicious for Acinic Cell Carcinoma. Cell Block: Immunohistochemical Studies CYTOLOGIC DIAGNOSIS:
1 PRELIMINARY CYTOLOGIC DIAGNOSIS: Suspicious for Acinic Cell Carcinoma. Cell Block: Immunohistochemical Studies GCDFP-15 S-100 CYTOLOGIC DIAGNOSIS: Consistent with mammary analogue secretory carcinoma.
More informationCase Presentation 58 year old male with recent history of hematuria, for which he underwent cystoscopy. A 1.5 cm papillary tumor was found in the left lateral wall of the bladder. Pictures of case Case
More informationPapillary Lesions of the Breast A Practical Approach to Diagnosis. (Arch Pathol Lab Med. 2016;140: ; doi: /arpa.
Papillary Lesions of the Breast A Practical Approach to Diagnosis (Arch Pathol Lab Med. 2016;140:1052 1059; doi: 10.5858/arpa.2016-0219-RA) Papillary lesions of the breast Span the spectrum of benign,
More informationAdenocarcinoma of the Cervix
Question 1. Each of the following statements about cervical adenocarcinoma is true except: Adenocarcinoma of the Cervix SAMS a) A majority of women with cervical adenocarcinoma have stage I tumors at diagnosis.
More informationUpdate in Salivary Gland Pathology. Benjamin L. Witt University of Utah/ARUP Laboratories February 9, 2016
Update in Salivary Gland Pathology Benjamin L. Witt University of Utah/ARUP Laboratories February 9, 2016 Objectives Review the different appearances of a selection of salivary gland tumor types Establish
More informationHow to Recognize Gynecologic Cancer Cells from Pelvic Washing and Ascetic Specimens
How to Recognize Gynecologic Cancer Cells from Pelvic Washing and Ascetic Specimens Wenxin Zheng, M.D. Professor of Pathology and Gynecology University of Arizona zhengw@email.arizona.edu http://www.zheng.gynpath.medicine.arizona.edu/index.html
More informationQuiz. b. 4 High grade c. 9 Unknown
Quiz 1. 10/11/12 CT scan abdomen/pelvis: Metastatic liver disease with probable primary colon malignancy. 10/17/12 Colonoscopy with polypectomy: Adenocarcinoma of sigmoid colon measuring at least 6 mm
More informationJ of Evolution of Med and Dent Sci/ eissn , pissn / Vol. 3/ Issue 24/June 16, 2014 Page 6628
ADENOCARCINOMA OF BLADDER-SIGNET RING CELL MUCINOUS VARIANT S. Senthil Kumar 1, D. Prem Charles 2, B. Krishnaswamy 3, P. Viswanathan 4, S. Sarath Chandran 5 HOW TO CITE THIS ARTICLE: S. Senthil Kumar,
More informationProtocol for the Examination of Specimens From Patients With Carcinoma of the Urethra and Periurethral Glands
Protocol for the Examination of Specimens From Patients With Carcinoma of the Urethra and Periurethral Glands Version: Protocol Posting Date: June 2017 Includes ptnm requirements from the 8 th Edition,
More informationNew Developments in Immunohistochemistry for Gynecologic Pathology
New Developments in Immunohistochemistry for Gynecologic Pathology Michael T. Deavers, M.D. Professor, Departments of Pathology and Gynecologic Oncology Immunohistochemistry in Gynecologic Pathology Majority
More informationTHE DIFFICULT DIAGNOSIS IN THE URINARY BLADDER: A SELECTIVE CONSIDERATION, MULLERIAN AND MULLERIAN- LIKE CONDITIONS. Robert H. Young, M.D.
THE DIFFICULT DIAGNOSIS IN THE URINARY BLADDER: A SELECTIVE CONSIDERATION, MULLERIAN AND MULLERIAN- LIKE CONDITIONS Robert H. Young, M.D. Benign and malignant müllerian lesions Mullerian-like appearances
More informationNeuroendocrine tumors of GI and Pancreatobiliary tracts. N. Volkan Adsay, MD
Neuroendocrine tumors of GI and Pancreatobiliary tracts N. Volkan Adsay, MD New (2017) WHO WHO 2017 (endocrine book; for pancreas) WHO 2017 (endocrine book; for pancreas) PD-NE ca WD-NE Tumor Intended
More informationPresentation material is for education purposes only. All rights reserved URMC Radiology Page 1 of 98
Presentation material is for education purposes only. All rights reserved. 2011 URMC Radiology Page 1 of 98 Radiology / Pathology Conference February 2011 Brooke Koltz, Cytopathology Resident Presentation
More informationCutaneous metastases. Thaddeus Mully. University of California, San Francisco Professor, Departments of Pathology and Dermatology
Cutaneous metastases Thaddeus Mully University of California, San Francisco Professor, Departments of Pathology and Dermatology DISCLOSURE OF RELATIONSHIPS WITH INDUSTRY Thaddeus Mully Course C005 Essential
More informationHistology Coding ANSWERS
Histology Coding ANSWERS 1.) Biopsy of a right thyroid nodule reveals papillary carcinoma. What is the ICD-O-3 code? a. 8050/3 - Papillary carcinoma b. 8260/3 - Papillary adenocarcinoma Rationale/comment:
More informationAtypical Hyperplasia/EIN
EIN Atypical Hyperplasia/EIN Based on scientific and diagnostic advances, in 2014 the WHO moved that the precursor lesion for endometrioid carcinoma be atypical hyperplasia/ein, rather than what was previously
More information3/28/2017. Disclosure of Relevant Financial Relationships. GU Evening Subspecialty Case Conference. Differential Diagnosis:
GU Evening Subspecialty Case Conference Rajal B. Shah, M.D. VP, Medical Director, Urologic Pathology Miraca Life Sciences, Irving, Texas Clinical Associate Professor of Pathology Baylor College of Medicine,
More informationOncocytic-Appearing Salivary Gland Tumors. Oncocytic, Cystic, Mucinous, and High Grade Salivary Gland Tumors SALIVARY GLAND FNA: PART II
William C. Faquin, MD, PhD Professor of Pathology Harvard Medical School Director of Head and Neck Pathology Massachusetts Eye and Ear Massachusetts General Hospital SALIVARY GLAND FNA: PART II Oncocytic,
More information6/3/2010. Outline of Talk. Lobular Breast Cancer: Definition of lobular differentiation. Common Problems in Diagnosing LCIS in Core Biopsies
Outline of Talk Lobular Breast Cancer: Common Problems in Diagnosing LCIS in Core Biopsies Definition of lobular differentiation Variants of LCIS that: carry risk for unsampled invasive cancer mimic DCIS
More informationProtocol for the Examination of Specimens From Patients With Carcinoma of the Urinary Bladder
Protocol for the Examination of Specimens From Patients With Carcinoma of the Urinary Bladder Version: Protocol Posting Date: June 2017 Includes ptnm requirements from the 8 th Edition, AJCC Staging Manual
More informationProtocol for the Examination of Specimens from Patients with Carcinoma of the Urinary Bladder
Protocol for the Examination of Specimens from Patients with Carcinoma of the Urinary Bladder Protocol applies primarily to invasive and noninvasive carcinomas, including carcinoma in situ. Version: Protocol
More informationUropathology January Jon Oxley
Uropathology January 2012 Jon Oxley Background to seminar These slides were available to view via the web from scanned slides The junior pathologists answered questions on them via the web The answers
More informationInt J Clin Exp Pathol 2015;8(3): /ISSN: /IJCEP Shogo Tajima 1, Kenji Koda 2
Int J Clin Exp Pathol 2015;8(3):3288-3293 www.ijcep.com /ISSN:1936-2625/IJCEP0005608 Case Report Transition between urothelial carcinoma in situ and non-invasive micropapillary carcinoma as a pivot connection
More informationInteractive Staging Bee
Interactive Staging Bee ROBIN BILLET, MA, CTR GA/SC REGIONAL CONFERENCE NOVEMBER 6, 2018? Clinical Staging includes any information obtained about the extent of cancer obtained before initiation of treatment
More informationCase Report Aggressive invasive micropapillary salivary duct carcinoma of the parotid gland
Pathology International 2008; 58: 322 326 doi:10.1111/j.1440-1827.2008.02231.x Case Report Aggressive invasive micropapillary salivary duct carcinoma of the parotid gland Hidetaka Yamamoto, 1 Hideoki Uryu,
More information6/5/2010. Renal vein invasion & Capsule Penetration (T3a) Adrenal Gland involvement (T4 vs. M1) Beyond Gerota s Fascia? (?T4).
GU Cancer Staging: Updates and Challenging Areas 13 th Current Issues in Surgical Pathology San Francisco, CA June 5, 2010 Jeffry P. Simko, PhD, MD Associate Professor Departments of Urology and Anatomic
More informationA patient with recurrent bladder cancer presents with the following history:
MP/H Quiz A patient with recurrent bladder cancer presents with the following history: 9/23/06 TURB 1/12/07 TURB 4/1/07 TURB 7/12/07 TURB 11/14/07 Non-invasive papillary transitional cell carcinoma from
More informationStaging Challenges in Lower GI Cancers. Disclosure of Relevant Financial Relationships. AJCC 8 th edition and CAP protocol updates
Staging Challenges in Lower GI Cancers Sanjay Kakar, MD University of California, San Francisco March 05, 2017 Disclosure of Relevant Financial Relationships USCAP requires that all planners (Education
More informationPathology of bladder cancer in Egypt; a current study.
Pathology of bladder cancer in Egypt; a current study. Thesis Submitted for partial fulfillment of Master degree in urology By Mohamed Atef Mohamed Ahmed M.B.B.CH Supervised by Prof.Dr.: Omar Mohamed Abdel-
More informationProtocol for the Examination of Cystectomy Specimens From Patients With Carcinoma of the Urinary Bladder
Protocol for the Examination of Cystectomy Specimens From Patients With Carcinoma of the Urinary Bladder Version: UrinaryBladder 4.0.1.1 Protocol Posting Date: February 2019 CAP Laboratory Accreditation
More informationBreast Pathology. Breast Development
Breast Pathology Lecturer: Hanina Hibshoosh, M.D. Reading: Kumar, Cotran, Robbins, Basic Pathology, 6th Edition, pages 623-635 Breast Development 5th week - thickening of the epidermis - milk line 5th
More informationGuidelines for the Management of Bladder Cancer West Midlands Expert Advisory Group for Urological Cancer
Guidelines for the Management of Bladder Cancer West Midlands Expert Advisory Group for Urological Cancer West Midlands Clinical Networks and Clinical Senate Coversheet for Network Expert Advisory Group
More informationInternational Society of Gynecological Pathologists Symposium 2007
International Society of Gynecological Pathologists Symposium 2007 Anais Malpica, M.D. Department of Pathology The University of Texas M.D. Anderson Cancer Center Grading of Ovarian Cancer Histologic grade
More information비뇨병리연구회공청회 조남훈 연세대학교병리학교실
비뇨병리연구회공청회 조남훈 연세대학교병리학교실 종양분류코드 - 방광암 표재성방광암 근층비침윤암 (Ta, Tis/ T1) 종양분류코드 진단서 ICD vs. ICO 사보험지급기준 중증질환분류 암등록사업 공보험 80-90% 지급기준 0 기암 -pta, ptis 특이한유형 면역 / 항암치료필요 재발과병기진행 다발성여부 진단확정주체 병리진단서 임상소견서 의무기록사 종양분류코드의변천사
More informationURINARY TRACT CARCINOMA - TRANSURETHRAL RESECTION AND BIOPSY STRUCTURED REPORTING PROTOCOL (1st Edition 2018)
URINARY TRACT CARCINOMA - TRANSURETHRAL RESECTION AND BIOPSY STRUCTURED REPORTING PROTOCOL (1st Edition 2018) Incorporating the: International Collaboration on Cancer Reporting (ICCR) Dataset for the reporting
More informationNeoplasms of the Prostate and Bladder
Neoplasms of the Prostate and Bladder 2015-2016 FCDS Educational Webcast Series Steven Peace, BS, CTR September 19, 2015 2015 Focus o Anatomy o SSS 2000 o MPH Rules o AJCC TNM 1 CDC & Florida DOH Attribution
More informationLesions Mimicking Adenoid Cystic Carcinoma. Diagnostic Problems in Salivary Gland Pathology An Update 5/29/2009
Diagnostic Problems in Salivary Gland Pathology An Update Lesions Mimicking Adenoid Cystic Carcinoma Stacey E. Mills, M.D. W.S. Royster Professor of Pathology Director of Surgical and Cytopathology University
More informationMacro- and microacinar proliferations of the prostate
Macro- and microacinar proliferations of the prostate (with emphasis on cancer mimics) Rodolfo Montironi, MD (IT), FRCPath (UK), IFCAP (USA) Polytechnic University of Marche Region (Ancona) School of Medicine,
More informationObjectives. Atypical Glandular Cells. Atypical Endocervical Cells. Reactive Endocervical Cells
2013 California Society of Pathologists 66 th Annual Meeting San Francisco, CA Atypical Glandular Cells to Early Invasive Adenocarcinoma: Cervical Cytology and Histology Christina S. Kong, MD Associate
More informationBLADDER CANCER: PATIENT INFORMATION
BLADDER CANCER: PATIENT INFORMATION The bladder is the balloon like organ located in the pelvis that stores and empties urine. Urine is produced by the kidneys, is conducted to the bladder by the ureters,
More informationThe Depth of Tumor Invasion is Superior to 8 th AJCC/UICC Staging System to Predict Patients Outcome in Radical Cystectomy.
30 th Congress of the European Society of Pathology Tuesday, September 11, 2018 The Depth of Tumor Invasion is Superior to 8 th AJCC/UICC Staging System to Predict Patients Outcome in Radical Cystectomy.
More information04/10/2018. Intraductal Papillary Neoplasms Of Breast INTRADUCTAL PAPILLOMA
Intraductal Papillary Neoplasms Of Breast Savitri Krishnamurthy MD Professor of Pathology Deputy Division Head The University of Texas MD Anderson Cancer Center 25 th Annual Seminar in Pathology Pittsburgh,
More informationperformed to help sway the clinician in what the appropriate diagnosis is, which can substantially alter the treatment of management.
Hello, I am Maura Polansky at the University of Texas MD Anderson Cancer Center. I am a Physician Assistant in the Department of Gastrointestinal Medical Oncology and the Program Director for Physician
More informationPlasmacytoid Variant Urothelial Carcinoma: Diagnostic and Grossing Challenges. Kailyn Gibson MS, PA-ASCP, Congli Wang, MD
1 Plasmacytoid Variant Urothelial Carcinoma: Diagnostic and Grossing Challenges Kailyn Gibson MS, PA-ASCP, Congli Wang, MD Johns Hopkins Hospital Department of Surgical Pathology 2 Plasmacytoid Variant
More informationEQA Circulation 43 Educational Cases
EQA Circulation 43 Educational Cases E1-E2 Monica Agarwal Monklands Hospital E1 38 yrs male Submandibular gland tumour E1 Formal excision following diagnosis of poorly differentiated carcinoma on core
More information