Endocrine Immunology

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1 Endocrine Immunology

2 Frontiers of Hormone Research Vol. 48 Series Editor Ezio Ghigo Turin Co-Editor Federica Guaraldi Turin

3 Endocrine Immunology Volume Editors Wilson Savino Rio de Janeiro Federica Guaraldi Turin 19 figures, 12 in color, and 11 tables, 2017 Basel Freiburg Paris London New York Chennai New Delhi Bangkok Beijing Shanghai Tokyo Kuala Lumpur Singapore Sydney

4 Frontiers of Hormone Research Founded 1972 by Tj.B. van Wimersma Greidanus, Utrecht Continued by Ashley B. Grossman, Oxford ( ) Wilson Savino, PhD Laboratory on Thymus Research National Institute of Science and Technology on Neuroimmunomodulation (INCT-NIM) Oswaldo Cruz Institute, Oswaldo Cruz Foundation Rio de Janeiro (Brazil) Federica Guaraldi, MD, PhD Division of Endocrinology, Diabetes and Metabolism Department of Medical Sciences University of Turin Turin (Italy) Library of Congress Cataloging-in-Publication Data Names: Savino, W. (Wilson), editor. Guaraldi, Federica, editor. Title: Endocrine immunology / volume editors, Wilson Savino, Federica Guaraldi. Other titles: Frontiers of hormone research ; v Description: Basel ; New York : Karger, [2017] Series: Frontiers of hormone research, ISSN ; vol. 48 Includes bibliographical references and index. Identifiers: LCCN ISBN (hard cover : alk. paper) ISBN (electronic version) Subjects: MESH: Endocrine System--immunology Endocrine System--physiology Immunomodulation--immunology Hormones--immunology Autoimmunity--immunology Classification: LCC RC649 NLM WK 100 DDC 616.4/071--dc23 LC record available at Bibliographic Indices. This publication is listed in bibliographic services, including Current Contents and PubMed/MEDLINE. Disclaimer. The statements, opinions and data contained in this publication are solely those of the individual authors and contributors and not of the publisher and the editor(s). The appearance of advertisements in the book is not a warranty, endorsement, or approval of the products or services advertised or of their effectiveness, quality or safety. The publisher and the editor(s) disclaim responsibility for any injury to persons or property resulting from any ideas, methods, instructions or products referred to in the content or advertisements. Drug Dosage. The authors and the publisher have exerted every effort to ensure that drug selection and dosage set forth in this text are in accord with current recommendations and practice at the time of publication. However, in view of ongoing research, changes in government regulations, and the constant flow of information relating to drug therapy and drug reactions, the reader is urged to check the package insert for each drug for any change in indications and dosage and for added warnings and precautions. This is particularly important when the recommended agent is a new and/or infrequently employed drug. All rights reserved. No part of this publication may be translated into other languages, reproduced or utilized in any form or by any means electronic or mechanical, including photocopying, recording, microcopying, or by any information storage and retrieval system, without permission in writing from the publisher. Copyright 2017 by S. Karger AG, P.O. Box, CH 4009 Basel (Switzerland) Printed on acid-free and non-aging paper (ISO 9706) ISSN e-issn ISBN e-isbn

5 Contents VII Preface Savino, W. (Rio de Janeiro); Guaraldi, F.; Ghigo, E. (Turin) 1 Immune-Neuro-Endocrine Reflexes, Circuits, and Networks: Physiologic and Evolutionary Implications del Rey, A.; Besedovsky, H.O. (Marburg) 19 Inflammation and Thymus Ageing Lepletier, A. (Melbourne/Brisbane); Alsharif, A.; Chidgey, A.P. (Melbourne) 37 Intrahypophyseal Immune-Endocrine Interactions: Endocrine Integration of the Inflammatory Inputs Renner, U. (Munich); Sapochnik, M. (Buenos Aires); Lucia, K.; Stalla, G.K. (Munich); Arzt, E. (Buenos Aires) 48 Pituitary Autoimmunity Guaraldi, F.; Giordano, R.; Grottoli, S.; Ghizzoni, L.; Arvat, E.; Ghigo, E. (Turin) 69 Prolactin: An Immunomodulator in Health and Disease Savino, W. (Rio de Janeiro) 76 A Novel Clinical Entity of Autoimmune Endocrinopathy: Anti-PIT-1 Antibody Syndrome Iguchi, G.; Bando, H.; Takahashi, Y. (Kobe) 84 Leptin, Neuroinflammation and Obesity Dragano, N.R.V.; Haddad-Tovolli, R.; Velloso, L.A. (Campinas) 97 Thyroid Autoimmunity and Cancer Felicetti, F.; Catalano, M.G.; Fortunati, N. (Turin) 110 Role of Cortistatin in the Stressed Immune System Delgado, M.; Gonzalez-Rey, E. (Granada) 121 Steroids and Autoimmunity Trombetta, A.C.; Meroni, M.; Cutolo, M. (Genova) 133 Endocrine Autoimmunity in Down s Syndrome Guaraldi, F.; Rossetto Giaccherino, R.; Lanfranco, F.; Motta, G. (Turin); Gori, D. (Bologna); Arvat, E.; Ghigo, E.; Giordano, R. (Turin) 147 The Somatotrope Growth Hormone-Releasing Hormone/Growth Hormone/ Insulin-Like Growth Factor-1 Axis in Immunoregulation and Immunosenescence Bodart, G.; Farhat, K.; Charlet-Renard, C. (Liege-Sart Tilman); Salvatori, R. (Baltimore, Md.); Geenen, V.; Martens, H. (Liege-Sart Tilman) V

6 160 Endocrine Immunology of Chagas Disease Savino, W. (Rio de Janeiro) 176 Author Index 177 Subject Index VI Contents

7 Preface In the last decades, in vivo and in vitro studies have demonstrated the existence of a complex and bidirectional network between the immune, nervous and endocrine systems. Thymus, brain, and the hypothalamic pituitary system play a pivotal role in the processing, modulation, integration, and regulation of immune (both innate and acquired systems)-neuro-endocrine responses, which, in turn, influence immune tolerance, course of transmissible infections, inflammatory and neoplastic diseases. More recently, dopamine agonists (D2) have been demonstrated to be efficacious in the treatment of some systemic autoimmune diseases associated with hyperprolactinemia, thus highlighting the importance of hormones in the regulation of the immune system function, in both health and disease. This volume provides an authoritative and comprehensive update on the genetic and molecular mechanisms underlying the physiological interplay between neuroendocrine and immune systems, and some illustrative examples of altered immune function associated with infectious and neoplastic diseases. Therefore, it is primarily addressed to clinicians and basic scientists working in the field of endocrinology and immunology, but could be also useful for internists and general practitioners. We are very grateful to the authors for their dedication and expert contribution, and to Rebecca Ganz and Thomas Nold at Karger Publishing for their valuable assistance at all stages of the volume conception and production. Wilson Savino, Rio de Janeiro, Brazil Volu me E d itor Federica Guaraldi, Turin, Italy Volume Editor and Series Co-Editor Ezio Ghigo, Turin, Italy S er ie s E d itor VII

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