NEW IHC A n t i b o d i e s

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1 NEW IHC Antibodies

2 TABLE OF CONTENTS NEW IHC ANTIBODIES from Cell Marque CITED1 (5H6) Claudin 7 (5D10F3) GATA1 (4F5) Transgelin (2A10C2) NEW IHC ANTIBODIES using RabMAb Technology from Abcam CD103 (EP206) ERG (EP111) IMP3 (EP286) Islet-1 (EP283) MCM3 (EP202) Mesothelin (EP140)... 3 NKX3.1 (EP356)... 3 SATB2 (EP281)... 3 ADDITIONAL ADVANCES using RabMAb Technology from Abcam Alpha-Fetoprotein (EP209)... 4 BCL6 (EP278) Carbonic Anhydrase IX (CA IX) (EP161)... 4 CD2 (EP222)... 4 CD4 (EP204)... 4 CD5 (EP77) CD7 (EP132)... 4 CD19 (EP169) CD31 (EP78)... 4 CD138 (EP201) Cyclin D1 (EP12)... 4 Cytokeratin 17 (EP98)... 4 Desmin (EP15) FSH (EP257) GH (EP267)... 5 Glucagon (EP74) Granzyme B (EP230) Hepatocyte Specific Antigen (Hep-Par1) (EP265) Her2/Neu (EP3)... 5 IgA (EP170) IgD (EP173) IgG4 (EP138) Kappa (EP171) Lambda (EP172)... 5 Lysozyme (EP134) Mammaglobin (EP249) Myeloperoxidase (EP151) Myogenin (EP162)... 5 Napsin A (EP205) Neurofilament (EP79)... 6 Olig2 (EP112) PAX-2 (EP235) PAX-5 (EP156) Prolactin (EP193) Somatostatin (EP130) SOX-10 (EP268)... 6 TSH (EP254) TTF-1 (EP229) Villin (EP163).... 6

3 New IHC Antibodies 1 CITED1 (5H6) CITED1 is a nuclear transcription factor that regulates self-renewing nephrogenic progenitor cells of the embryonal kidney. CITED1 is a highly specific marker for Wilms Tumor and can be comparable to, if not exceed, the specificity of WT1. CITED1 is positively expressed in 90% of Wilms Tumor cases. 0.1 ml, concentrate M ml, concentrate M ml, concentrate M ml, predilute M ml, predilute M-18 5 Positive control slides S Claudin 7 (5D10F3) Claudin 7 is a sensitive and specific marker for differentiating chromophobe renal cell carcinoma (a malignancy) from benign renal oncocytoma. Morphologic similarities may make this differential diagnosis difficult without the aid of immunohistochemistry. Chromophobe renal cell carcinoma strongly expresses claudin 7, and anti-claudin 7 should be used in a renal cell panel as a complimentary antibody to anti-s100a1, which is strongly expressed in claudin 7-negative oncocytoma. 0.1 ml, concentrate M ml, concentrate M ml, concentrate M ml, predilute M ml, predilute M-18 5 Positive control slides S GATA1 (4F5) Acute megakaryoblastic leukemia (AMKL) is a subtype of acute myeloid leukemia (AML) that can be challenging to diagnose due to morphologic heterogeneity, poor bone marrow (BM) aspiration secondary to fibrosis, and few reliable markers to confirm megakaryocytic differentiation in decalcified, paraffin-embedded tissue sections. Although rare, this subtype of AML occurs more frequently in children and proper identification is critical for guidance of clinical management, prognostication, and appropriate ancillary testing. The transcription factor GATA1 plays a key role in physiologic megakaryocytic and erythroid development, and mutations in this gene underlie some leukemias deriving from these cell types. GATA1 expression in BM is limited to megakaryocytic and erythroid lineages. The sensitivity and specificity for GATA1 staining in AMKL are 70% and 94%, respectively. Down s Syndrome patients that are GATA1 negative may have mutations that alter the epitope recognized by the antibody ml, concentrate M ml, concentrate M ml, concentrate M ml, predilute M ml, predilute M-18 5 Positive control slides S Transgelin (2A10C2) Leiomyosarcoma (LMS) is the most frequent soft tissue sarcoma histotype (15% of sarcomas). Transgelin is a sensitive marker for differentiating LMS from rhabdomyosarcoma. In a study that compared transgelin with other myogenic markers such as smooth muscle actin, desmin, h-caldesmon, and calponin, transgelin was the best overall marker for differentiating leiomyosarcoma from other sarcomas, and GIST ml, concentrate M ml, concentrate M ml, concentrate M ml, predilute M ml, predilute M-18 5 Positive control slides S

4 New IHC Antibodies 2 CD103 (EP206) Various markers are utilized for hairy cell leukemia diagnosis; CD103 rabbit monoclonal is one of the newest markers available for immunohistochemistry. According to literature, among the CD103 antibodies used in the diagnosis of hairy cell leukemia for applications such as flow cytometry, the rabbit monoclonal antibody is the only one that works on formalin fixed, paraffin embedded tissue ml, concentrate R ml, concentrate R ml, concentrate R ml, predilute R ml, predilute R-18 5 Positive control slides S ERG (EP111) ERG is an important novel marker for the identification of vascular neoplasms due its strong and specific nuclear expression in endothelial cells. ERG is strongly expressed in Kaposi sarcoma, which is usually associated with HHV-8, as well as other vascular tumors such as hemangioendothelioma and angiosarcoma. ERG has shown to be a valuable addition to an endothelial panel that includes Factor VIII, CD31, CD34, and D2-40. ERG is also helpful in identifying prostate adenocarcinoma. With its nuclear staining properties, ERG is able to differentiate prostate adenocarcinoma from low grade PIN and hyperplastic cells. ERG is a more specific marker than the established P504s for prostate cancer. 0.1 ml, concentrate R ml, concentrate R ml, concentrate R ml, predilute R ml, predilute R-18 5 Positive control slides S IMP3 (EP286) IMP3 is a useful marker in identifying pancreatic ductal adenocarcinoma and distinguishing this from benign pancreatic lesions, such as chronic pancreatitis. IMP3 is also known to be strongly expressed in Reed-Sternberg (RS) cells in classic Hodgkin s lymphoma (chl). The advantage of this marker for chl is that it does not stain immunoblasts or background neutrophils, eosinophils and macrophages and is more sensitive than the more traditional markers CD30 and CD15. It is also positive in the popcorn cells of nodular lymphocyte predominant Hodgkin s lymphoma that are usually negative for CD30 and CD ml, concentrate R ml, concentrate R ml, concentrate R ml, predilute R ml, predilute R-18 5 Positive control slides S Islet-1 (EP283) Islet-1 is a neuroendocrine marker that labels islets in the pancreas. According to literature, Islet-1 is helpful in distinguishing between well-differentiated and poorly-differentiated pancreatic neuroendocrine neoplasms. It has also demonstrated positivity in the majority of extrapancreatic neuroendocrine neoplasms ml, concentrate R ml, concentrate R ml, concentrate R ml, predilute R ml, predilute R-18 5 Positive control slides S

5 New IHC Antibodies 3 MCM3 (EP202) MCM3 is a cost-effective proliferation marker. MCM3 s staining of proliferating cells is comparable to Ki-67 but unlike Ki-67, MCM3 also marks cells present in the intermediate layer of the epithelium which is typically negative for Ki-67. It is also more sensitive for salivary tumors compared to Ki-67. MCM3 can be most useful in a panel with markers such as PHH3 and Ki ml, concentrate R ml, concentrate R ml, concentrate R ml, predilute R ml, predilute R-18 5 Positive control slides S Mesothelin (EP140) Mesothelin is a marker utilized in differentiating mesothelioma from lung adenocarcinoma. Due to mesothelin s high sensitivity for mesothelioma, a negative stain essentially excludes mesothelioma. Mesothelin should be used in a panel with calretinin, cytokeratin 5&6, and Ep-CAM (Ber-EP4). 0.1 ml, concentrate R ml, concentrate R ml, concentrate R ml, predilute R ml, predilute R-18 5 Positive control slides S NKX3.1 (EP356) NKX3.1 is a transcription factor that is specific for prostate cancer. It is useful in distinguishing prostate from bladder and other non-prostate metastases. This nuclear marker has higher sensitivity and specificity than the already established PSA antibody for prostate carcinoma. 0.1 ml, concentrate R ml, concentrate R ml, concentrate R ml, predilute R ml, predilute R-18 5 Positive control slides S SATB2 (EP281) SATB2 is a nuclear marker that is valuable in diagnosing adenocarcinomas of the lower GI tract. It is useful in a diagnostic panel that includes cytokeratin 7, cytokeratin 20, and CDX-2. When used with cytokeratin 7 and cytokeratin 20, the specificity for colorectal carcinoma increases to 100% with the sensitivity over 90%. SATB2 has also been shown to identify medullary carcinomas of the colon that are often negative for cytokeratin 20 and CDX ml, concentrate R ml, concentrate R ml, concentrate R ml, predilute R ml, predilute R-18 5 Positive control slides S

6 Additional Advances 4 Alpha-Fetoprotein (EP209) 0.1 ml, concentrate R ml, concentrate R ml, concentrate R ml, predilute R ml, predilute R-18 5 Positive control slides S BCL6 (EP278) 0.1 ml, concentrate R ml, concentrate R ml, concentrate R ml, predilute R ml, predilute R-28 5 Positive control slides S Carbonic Anhydrase IX (CA IX) (EP161) 0.1 ml, concentrate R ml, concentrate R ml, concentrate R ml, predilute R ml, predilute R-18 5 Positive control slides S CD2 (EP222) 0.1 ml, concentrate R ml, concentrate R ml, concentrate R ml, predilute R ml, predilute R-18 5 Positive control slides S CD4 (EP204) 0.1 ml, concentrate R ml, concentrate R ml, concentrate R ml, predilute R ml, predilute R-28 5 Positive control slides S CD5 (EP77) 0.1 ml, concentrate R ml, concentrate R ml, concentrate R ml, predilute R ml, predilute R-28 5 Positive control slides S CD7 (EP132) 0.1 ml, concentrate R ml, concentrate R ml, concentrate R ml, predilute R ml, predilute R-18 5 Positive control slides S CD19 (EP169) 0.1 ml, concentrate R ml, concentrate R ml, concentrate R ml, predilute R ml, predilute R-18 5 Positive control slides S CD31 (EP78) 0.1 ml, concentrate R ml, concentrate R ml, concentrate R ml, predilute R ml, predilute R-28 5 Positive control slides S CD138 (EP201) 0.1 ml, concentrate R ml, concentrate R ml, concentrate R ml, predilute R ml, predilute R-28 5 Positive control slides S Cyclin D1 (EP12) 0.1 ml, concentrate R ml, concentrate R ml, concentrate R ml, predilute R ml, predilute R-48 5 Positive control slides S Cytokeratin 17 (EP98) 0.1 ml, concentrate R ml, concentrate R ml, concentrate R ml, predilute R ml, predilute R-18 5 Positive control slides S Desmin (EP15) 0.1 ml, concentrate R ml, concentrate R ml, concentrate R ml, predilute R ml, predilute R-18 5 Positive control slides S FSH (EP257) 0.1 ml, concentrate R ml, concentrate R ml, concentrate R ml, predilute R ml, predilute R-18 5 Positive control slides S

7 Additional Advances 5 GH (EP267) 0.1 ml, concentrate R ml, concentrate R ml, concentrate R ml, predilute R ml, predilute R-18 5 Positive control slides S Glucagon (EP74) 0.1 ml, concentrate R ml, concentrate R ml, concentrate R ml, predilute R ml, predilute R-18 5 Positive control slides S Granzyme B (EP230) 0.1 ml, concentrate R ml, concentrate R ml, concentrate R ml, predilute R ml, predilute R-18 5 Positive control slides S Hepatocyte Specific Antigen (Hep-Par1) (EP265) 0.1 ml, concentrate R ml, concentrate R ml, concentrate R ml, predilute R ml, predilute R-18 5 Positive control slides S Her2/Neu (EP3) 0.1 ml, concentrate R ml, concentrate R ml, concentrate R ml, predilute R ml, predilute R-28 5 Positive control slides S IgA (EP170) 0.1 ml, concentrate R ml, concentrate R ml, concentrate R ml, predilute R ml, predilute R-18 5 Positive control slides S IgD (EP173) 0.1 ml, concentrate R ml, concentrate R ml, concentrate R ml, predilute R ml, predilute R-18 5 Positive control slides S IgG4 (EP138) 0.1 ml, concentrate R ml, concentrate R ml, concentrate R ml, predilute R ml, predilute R-18 5 Positive control slides S Kappa (EP171) 0.1 ml, concentrate R ml, concentrate R ml, concentrate R ml, predilute R ml, predilute R-18 5 Positive control slides S Lambda (EP172) 0.1 ml, concentrate R ml, concentrate R ml, concentrate R ml, predilute R ml, predilute R-18 5 Positive control slides S Lysozyme (EP134) 0.1 ml, concentrate R ml, concentrate R ml, concentrate R ml, predilute R ml, predilute R-18 5 Positive control slides S Mammaglobin (EP249) 0.1 ml, concentrate R ml, concentrate R ml, concentrate R ml, predilute R ml, predilute R-28 5 Positive control slides S Myeloperoxidase (EP151) 0.1 ml, concentrate R ml, concentrate R ml, concentrate R ml, predilute R ml, predilute R-28 5 Positive control slides S Myogenin (EP162) 0.1 ml, concentrate R ml, concentrate R ml, concentrate R ml, predilute R ml, predilute R-18 5 Positive control slides S

8 Additional Advances 6 Napsin A (EP205) 0.1 ml, concentrate R ml, concentrate R ml, concentrate R ml, predilute R ml, predilute R-18 5 Positive control slides S Neurofilament (EP79) 0.1 ml, concentrate R ml, concentrate R ml, concentrate R ml, predilute R ml, predilute R-18 5 Positive control slides S Olig2 (EP112) 0.1 ml, concentrate R ml, concentrate R ml, concentrate R ml, predilute R ml, predilute R-18 5 Positive control slides S PAX-2 (EP235) 0.1 ml, concentrate R ml, concentrate R ml, concentrate R ml, predilute R ml, predilute R-18 5 Positive control slides S PAX-5 (EP156) 0.1 ml, concentrate R ml, concentrate R ml, concentrate R ml, predilute R ml, predilute R-28 5 Positive control slides S Prolactin (EP193) 0.1 ml, concentrate R ml, concentrate R ml, concentrate R ml, predilute R ml, predilute R-18 5 Positive control slides S References Somatostatin (EP130) 0.1 ml, concentrate R ml, concentrate R ml, concentrate R ml, predilute R ml, predilute R-18 5 Positive control slides S SOX-10 (EP268) 0.1 ml, concentrate R ml, concentrate R ml, concentrate R ml, predilute R ml, predilute R-18 5 Positive control slides S TSH (EP254) 0.1 ml, concentrate R ml, concentrate R ml, concentrate R ml, predilute R ml, predilute R-18 5 Positive control slides S TTF-1 (EP229) 0.1 ml, concentrate R ml, concentrate R ml, concentrate R ml, predilute R ml, predilute R-18 5 Positive control slides S Villin (EP163) 0.1 ml, concentrate R ml, concentrate R ml, concentrate R ml, predilute R ml, predilute R-18 5 Positive control slides S 1. King RL, et al. GATA1 Immunohistochemistry Is a Sensitive and Specific Marker for Pediatric Acute Megakaryoblastic Leukemia. Poster presented at: United States & Canadian Academy of Pathology Annual Meeting; March 2014; San Diego, CA. 2. Robin YM, et al. Mod Pathol. 2013; 26: Morgan EA, et al. Am J Clin Pathol. 2013; 139: Agaimy A, et al. Mod Pathol. 2013; 26: Sigma-Aldrich Co. LLC. All rights reserved. SIGMA-ALDRICH and Cell Marque are trademarks of Sigma-Aldrich Co. Rev. 0.0 Toll-Free: Direct:

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