MR spectroscopy in breast cancer: retrospective study of a population with high prevalence of disease

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1 MR spectroscopy in breast cancer: retrospective study of a population with high prevalence of disease Poster No.: C-2025 Congress: ECR 2015 Type: Scientific Exhibit Authors: D. De Falco Alfano 1, R. N. Abousiam 2, R. Duati 2, E. Cagnati 2, N. Keywords: DOI: Murri dello Diago 2, M. Giganti 2 ; 1 Cona/IT, 2 Ferrara/IT Cancer, Diagnostic procedure, MR-Spectroscopy, Breast /ecr2015/C-2025 Any information contained in this pdf file is automatically generated from digital material submitted to EPOS by third parties in the form of scientific presentations. References to any names, marks, products, or services of third parties or hypertext links to thirdparty sites or information are provided solely as a convenience to you and do not in any way constitute or imply ECR's endorsement, sponsorship or recommendation of the third party, information, product or service. ECR is not responsible for the content of these pages and does not make any representations regarding the content or accuracy of material in this file. As per copyright regulations, any unauthorised use of the material or parts thereof as well as commercial reproduction or multiple distribution by any traditional or electronically based reproduction/publication method ist strictly prohibited. You agree to defend, indemnify, and hold ECR harmless from and against any and all claims, damages, costs, and expenses, including attorneys' fees, arising from or related to your use of these pages. Please note: Links to movies, ppt slideshows and any other multimedia files are not available in the pdf version of presentations. Page 1 of 10

2 Aims and objectives Aim of the present study is to evaluate the correlation between histologic grading of breast carcinoma and presence of choline peak ( tcho) using MR spetroscopy sequence. Methods and materials 58 women (range years) were retrospectively analyzed; suspected malignacy lesions were detected by mammography or ultrasound and than Magnetic Resonance Spectroscopy was performed in all patients (between February 2010 through April 2014). 60 lesions were analyzed, 20 of which were found at the histological examination as grade II, 20 as grade III and 20 grade I lesions. Non-continuous variables were considered, especially the variable grading and the tcho variable. The sensitivity of spectroscopic examination and its IC95 (confidence interval 95%) has been calculated and statistical analysis has been made to evaluate the relationship between Grading variables and tcho, in particular it has been used Pearson's Chi-square test (#²) and Fisher's exact test (considering significant P-value < 0.05). Images for this section: Page 2 of 10

3 Fig. 1: CUP Syndrome: small area of enhancement surrounded by area of non masslike enhancement to the passage of the lower quadrants of the left breast. They are also recognizable axillary lymph nodes that represent the clinical onset of the disease. Page 3 of 10

4 Fig. 2: Analysis of dynamic enhancement. Page 4 of 10

5 Fig. 3: Analysis of dynamic enhancement shows a type 2 (plateau) signal intensity time Page 5 of 10

6 Fig. 4: DWI sequence: the ADC value is compatible with the proliferative disease Page 6 of 10

7 Fig. 5: Sequence of proton spectroscopy demonstrates the presence of a significant peak of Choline Page 7 of 10

8 Results The sensitivity were (76%). The histologic grade and the peak of choline showed a statistically significant relationship: # ² =6.592 p = Fisher's exact test produced similar results to those obtained using the Chi-square test (# ²): F = p = Conclusion With the increase of the histological grading (Gold Standard) it has been seen an increase in percentage of choline peaks. Personal information Daniele De Falco Alfano Morphology, Surgery and Experimental Medicine Diagnostic Imaging Section Ferrara University Hospital 4, Aldo Moro Street Ferrara Italy mail:defalco.md@gmail.com References 1. Sivajaran U, Jayapragasam KJ, Ramhat et al: Dynamic contrastenhancement MRI evaluation of breast lesions- amorphological and quantitative analysis. J HK Coll Radiol 2009; 12:46-55 Page 8 of 10

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