Sixth International Breast Cancer Prevention Symposium: Environmental impact, Nutrition and Cell Fate City of Hope, CA, USA October 12-13, 2016

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Sixth International Breast Cancer Prevention Symposium: Environmental impact, Nutrition and Cell Fate City of Hope, CA, USA October 12-13, 2016 Symposium (open to all) Tuesday, October 11, 2016 6:00

1 Sixth International Breast Cancer Prevention Symposium: Environmental impact, Nutrition and Cell Fate City of Hope, CA, USA October 12-13, 2016 Symposium (open to all) Tuesday, October 11, :00 pm Welcome Cocktail Party:, courtyard area Wednesday, October 12, :30-9:00 am Registration 9:00-9:15 am Welcome by the Co-Chairs (Drs. Seewaldt, Lelièvre, Weaver, Bellanger) and Dr. Timothy Ratliff, Purdue Center for Cancer Research, Purdue University :00 am Symposium Keynote: Pepper Schedin, PhD, Cell, Developmental & Cancer Biology, Oregon Health & Science University, Knight Cancer Center, Portland, OR, USA. "Developmental Windows of Breast Cancer Risk Provide Opportunities for Targeted Prevention" Session 1 Breast Cancer Prevention from around the world Chair: Graciela Sabini, MD, Ministry of Health, Montevideo, Uruguay Co-Chair: Ellen Gruenbaum, PhD, Department of Anthropology, Purdue University, USA 10:00-10:30 am Françoise Clavel-Chapelon, PhD, Institut National de la Santé et de la Recherche Médicale, Institut Gustave Roussy, France The French E3N and E4N cohorts. Major results and future projects 10:30-11:00 am Sundus Shalabi, MD, Al-Maqassed Hospital, Jerusalem, Palestine "Breast cancer in Palestine: Some Facts and Future Prospects" 11:00-11:20 am Break 11:20-11:50 am Carmen Marino Donangelo, PhD, University of the Republic, Uruguay "Challenges in understanding the impact of nutrition on breast cancer in Uruguay"

2 11:50 am-12:20 pm Hye-Kyung Na, PhD, Sungshin Women's University, South Korea Breast Cancer Preventive Potential of Some Dietary Phytochemicals" 12:20-2:20 pm Symposium opening lunch Susan Bulkeley Butler Leadership Excellence Award and lecture: Harold P. Freeman, MD., Patient Navigation Institute in New York City, NY, USA The Origin, Principles and Current Status of Patient Navigation Session 2 Bioactives in diet to prevent breast cancer Chair: Connie M. Weaver, PhD, Nutrition Science, Purdue University, USA Co-Chair: Lie-Fen Shyur, PhD, Agricultural Biotechnology Research Center, Tapei, Taiwan 2:30-3:00 pm Ailsa Welch, PhD, University of East Anglia, Norwich, England, UK Bioactives and prevention of breast cancer with an emphasis on carotenoids 3:00-3:30 pm Lisa D. Yee, MD, Surgical Oncology and High Risk Breast Cancer Program, The Ohio State University, USA Omega 3 fatty acids and breast cancer prevention 3:30-4:00 pm Pamela R. Pehrsson, PhD, USDA Agricultural Research Service, Beltsville, MD, USA USDA food composition databases: Support of research and programs to reduce breast cancer risk 4:00-4:30 pm Debate 4:30-5:00 pm Break Session 3 Environmental influence and population diversity Chair: Martine Bellanger, PhD, National School of Public Health, Rennes, France Co-Chair: Seth Wiafe, MPH, PhD, Loma Linda University School of Public Health, Loma Linda CA, USA 5:00-5:30 pm Victoria Seewaldt, PhD, Ruth Zigler Professor, Chair of the Department of Population Science, and Associate Cancer Center Director City of Hope Duarte, CA, USA Water, risk and imprinting

3 5:30-6:00 pm Susan Neuhausen, Ph.D., Beckman Research Institute, City of Hope, CA, USA Environmental chemicals and potential risk of breast cancer during the menopausal transition 7:00-9:00 pm Poster Session & Reception with Welcome Buffet Thursday, October :30-9:00 am (Registration- continued) Session 4 Epigenetics and [stem] cell fate Chair: Sharon Ross, PhD, Division of Cancer Prevention, National Cancer Institute, National Institutes of Health, Bethesda, MD, USA Co-Chair: Rihab Nasr, PhD, American University of Beirut 9:00-9:15 am Sharon Ross, introductory remarks 9:15-9:45 am Mark LaBarge, PhD, Life Science Division, Lawrence Berkeley National Laboratory, Berkeley CA, USA Age-related microenvironment-imposed epigenetic states make breast epithelia more susceptible to cancer 9:45-10:15 am Nicoletta Sacchi, Ph.D, Department of Cancer Genetics, Roswell Park Cancer Institute, Buffalo, NY, USA Tracing anti-cancer and cancer-promoting actions of all-trans retinoic acid to an epigenetic mechanism of mammary epithelial morphogenesis 10:15-11:00 am: Debate 11:00-11:20 am Break 11:20-11:50 am Special topic: Chun-Ju Chang, PhD, Department of Food Science, National Taiwan Ocean University, Taiwan "Dietary Constituents Regulate Cancer Progression and HER2 Expression in Mammary Epithelial Cells"

4 11:50 am-12:35 pm CATHERINE PEACHEY ORAL PRESENTATIONS (Graduate and postgraduate trainees) Chair: Rabih Talhouk, PhD, American University of Beirut, Lebanon 12:35-2:00 pm Lunch Emma Brew Abaidoo, BSc, Msc, Peace & Love Hospital, Kumasi, Ghana Incidence of triple negative breast cancer in Ghanaian women below age 50 Abena Ofosuah Addai, Peace & Love Hospital, Kumasi, Ghana Extending Survivorship through the HOPE Peer-Nurse Navigation in Ghana Parijat Senapati, PhD, City of Hope National Medical Center, Department of Diabetes and Metabolic Diseases Research, USA Hyperinsulinemia induced changes in chromatin acetylation and gene expression in triple negative breast cancer Session 5 Big data: Combining environmental impact and primary prevention Chair: Mary Beth Terry, PhD, Columbia University, New York, USA Co-Chair: Farah Naja, PhD, American University of Beirut, Lebanon 2:00-2:30 pm Nadia Atallah, PhD, Bioinformatician, Purdue Center for Cancer Research, Purdue University, West Lafayette, IN, USA Using single-cell transcriptomics to transform cancer prevention and treatment 2:30-3:00 pm Humam Kadara, PhD, American University of Beirut, Lebanon, Genomic architecture of lung cancer pathogenesis 3:00-3:30 pm Panel of experts/debate 3:30-4:00 pm Break Session 6 Environmental ethics and primary prevention of disease (Public Lectures) Chair: Leslie Reinlib, PhD, National Institute of Environment and Health Science, Washington, DC, USA Co-Chair: Delia Sánchez, MD, MPH, Academic Unit of Bioethics, School of Medicine, Universidad de la República, Montevideo, Uruguay

5 4:00-4:30 pm William Sherlaw, PhD, National School of Public Health, Rennes, France Health, health inequities, breast cancer & nutrition: Models & Insights from non-health sector policy and the disability world 4:30-5:00 pm Beatrice Wiafe-Addai, MD, PhD, Peace & Love Hospital, Kumasi, Ghana Environmental prevention strategies for reducing breast cancer in our communities 5:00-5:30 pm Peter Duncan, PhD, Kings College, London, UK Values, Ethics, Health Inequality and Cancer Policy: A French- English Case Study 5:30-5:50 pm Debate- wrap up [shopping time] 7:00 9:00 pm Symposium Party

Introduction: Developing a Global Collaboration to Study Diet and Non- Communicable Disease Prevention

Introduction: Developing a Global Collaboration to Study Diet and Non- Communicable Disease Prevention Connie Weaver, Ph.D. Purdue University West Lafayette, IN 47907 weavercm@purdue.edu Session- International