Editorial. The Puzzle of Prostatic Carcinoma
|
|
- Miles Fitzgerald
- 6 years ago
- Views:
Transcription
1 Editorial The Puzzle of Prostatic Carcinoma Carcinoma of the prostate is the most common malignant tumor in elderly men. Data from autopsy studies based on routine tissue sections indicate that the rate of occurrence of prostatic carcinoma increases sharply in persons older than 50 years of age. In the eighth decade of life, a mean of 34% of men (range, 20 to 52%) living in the Western hemisphere will harbor occult foci of this tumor. If histologic step sections are used, the rate of occurrence of occult cancer in persons of the same age group increases to a mean of 53% (range, 18 to 100%). 1 Thus, autopsy data strongly suggest that the clinically obvious cases represent only a fraction of all prostatic cancers. Nonetheless, cancer of the prostate as a clinical disease is the second most common cancer in American men, second only to lung cancer but with an exceedingly different behavior pattern, inasmuch as the course of the disease is often slow and the behavior of the tumor can be manipulated by hormonal therapy. 2 The issue is complicated further because of an apparent racial and geographic diversity associated with prostatic carcinoma. For example, the disease is more common and seems to behave more aggressively in American Blacks than in Whites. 3 Furthermore, overt prostatic carcinoma is rare in Japan, even though the rate of occult cancer in that country is similar to that in the United States. 3,4 Thus, the progression of occult carcinoma to overt clinical cancer is obviously not a simple cause-and-effect event. The reasons for these behavioral and biologic variables are totally obscure at this time. From the purely practical standpoint, cancer of the prostate poses two major diagnostic and therapeutic dilemmas. The first dilemma pertains Personal work cited in this editorial is supported by Grant CA from the National Cancer Institute, National Institutes of Health. Address reprint requests to Dr. L. G. Koss, Department of Pathology, Montefiore Medical Center, 111 East 210th Street, Bronx, NY Mayo Clin Proc 63: , to occult prostatic cancers that are disclosed as an incidental finding as a consequence of a transurethral resection or prostatectomy for benign disease or as a result of the increasingly used and effective thin-needle aspiration biopsy. 5 Whether to treat or not to treat patients with these lesions is the question. The second dilemma, which is at the other end of the diagnostic spectrum, is the problem of assessment of the effects of treatment and hence prognosis on clinically overt carcinomas, inasmuch as the behavior of these tumors is so capricious. The puzzle of occult prostatic carcinoma has been approached from many different points of view. Biochemical factors, such as elevation of the specific prostatic acid phosphatase and, more recently, specific prostatic antigen, have been proposed to identify men at risk for occult prostatic cancer or to follow the progression of the disease. 6-8 The question of what proportion of occult carcinomas, still confined to the prostate, will progress to metastatic disease has not been answered on prospective bases, in the absence of a long-term follow-up on a large group of patients, which is necessary for determining whether and to what extent the biochemical or microscopic abnormalities translate into clinical disease. The existing information is anecdotal. Thus, in a study of 117 patients with stage A prostatic cancer followed up without treatment, Cantrell and associates 9 reported progression of the disease in 32% of the patients. The progression was correlated to some extent with size and histologic grade of the tumor. Reciprocally, 68% of these patients apparently remained free of disease, a suggestion that most of the incidentally discovered prostatic carcinomas are not lifethreatening. Nevertheless, the urologist confronted with the dilemma and unable to predict the natural course of the disease will often choose to treat the patient, sometimes by orchiectomy with or without hormonal therapy and sometimes "for cure" by a prostatectomy. The results of treatment for stages A and B prostatic cancer in the absence of metastatic lesions seem to be excellent Hence, the iconoclastic question: Was the treatment necessary in the first place, and did it, in fact, contribute to the patient's survival and quality of life?
2 194 EDITORIAL Mayo Clin Proc, February 1988, Vol 63 The question is complicated by the fact that even patients with advanced stages of prostatic carcinoma who have no skeletal metastatic lesions may experience good survival. In some of these patients, the disease is arrested or perhaps even cured by surgical treatment, as reported by Winkler and associates in a study of patients with stage Dl prostatic carcinoma in this issue of the Proceedings (pages 103 to 112). Can the puzzle of occult prostatic carcinoma be solved? A common approach to the prognosis of patients with cancer has been histologic grading, pioneered by Broders at the Mayo Clinic in the 1920s. The application of this concept to the prostate, most notably the grading system suggested by Gleason and colleagues, 15 Utz and Farrow, 16 and Mostofi, 17 had as its purpose a correlation of histologic patterns with prognosis. Briefly, tumors that formed glands similar to normal prostatic glandular architecture were thought to be of low grade and hence associated with a better prognosis than tumors with growth patterns that showed various degrees of deviation from normal. Some problems with grading are that it often lacks reproducibility 18 and that the tumor patterns may vary from one histologic site to another, as noted by Gleason and coworkers, 15 who introduced a numerical grading system based on a combination of patterns. A grading of prostatic tumors into three groups based on Cytologie patterns in aspiration biopsy specimens was proposed by Esposti. 19 Usually, very well differentiated tumors have a protracted course, whereas poorly differentiated tumors, regardless of grading system, are associated with a poor prognosis and behave aggressively, the end result of which is rapid dissemination of the disease and death. For the bulk of prostatic carcinomas that have an intermediate grade of differentiation, the histologic or Cytologie grading sheds limited light on tumor behavior and thus on the potential for survival of the individual patient. The recognition that the prognostic value of histologic or Cytologie patterns of human cancer has severe limitations can be traced to the 1930s, when several German pathologists began to measure components of tumor cells in histologic sections in an attempt to extract objective useful data not immediately evident to the human eye. 20 These efforts were superseded by the developments in cytochemistry that led to measurement of specific cell components in Cytologie preparations, by using either ultraviolet light or the DNA-specific Feulgen stain, in a static laboratory procedure known as cytophotometry. 20 Further technical developments resulted in the construction of machines known as flow cytometers, which facilitate rapid measurement of DNA and other cell components in a large number of cells. 21 Fundamentally, flow cytometers are instruments that measure fluorescence; hence, the measurements must be based on the binding of the cell component to be measured (such as DNA in the cell nucleus) with an appropriate fluorescent dye for example, propidium iodide, as used by Winkler and associates in their current study. A method developed by Hedley and colleagues 22,23 allowed application of flow cytometry and cytophotometry to archival, paraffin-embedded tissue samples; thus, the scope of these measurements was extended substantially to include patients with a known clinical outcome. The concept that measuring DNA in human tumors may be of prognostic value was summarized in a recent editorial that addressed the issue of colonic cancer. 24 With the increasing availability of instrumentation, the search for objective prognostic measurements in patients with prostatic carcinoma continues. Prior studies, such as those by Auer and Zetterberg 25 who used cytophotometry on archival smears of prostatic aspirates and by Tribukait 26 who used flow cytometry of fresh cell and tissue samples, suggested that prostatic carcinomas with a dominant DNA content in the diploid range are associated with a better clinical outcome than are tumors with DNA values outside the normal range (that is, tetraploid and aneuploid). Furthermore, data presented by Tribukait 27 indicated that 80% of carcinomas still confined to the prostate were in the diploid range, whereas tumors that spread beyond the prostate were, for the most part, either aneuploidtetraploid or outright aneuploid. These data strongly suggested that DNA ploidy measurements may be of prognostic value. The current article by Winkler and co-workers, based on archival material, extends this concept still further namely, to stage Dl prostatic carcinomas treated surgically: those patients with tumors in the diploid range had a statistically significant better survival than patients with tumors that were either aneuploid-tetraploid or aneuploid. Somewhat similar although not quite
3 Mayo Clin Proc, February 1988, Vol 63 EDITORIAL 195 as optimistic information was reported by Stephenson and co-workers, 28 who measured DNA in metastatic lesions of prostatic cancer and who pointed out that patients with diploid-range tumors lived longer than patients with nondiploid tumors. Although retrospective studies have severe limitations for several technical reasons such as problems with preparation of samples and interpretation of histograms the broad canvas of this information is obviously encouraging and promises that measurement of DNA in prostatic cancer may be the flickering light in the prognostic darkness that ultimately may guide urologists in selecting optimal treatment for their patients. Unfortunately, stages C and D prostatic carcinomas with diploid-range DNA content are relatively few. Although Winkler and associates do not report what proportion of all advanced prostatic cancers seen at the Mayo Clinic had diploidrange histograms, experience from other sources suggests that only a relatively small group of patients have such cancers. Tribukait's data suggest that only 12% of T3 tumors (corresponding to stage C) and 2% of T4 tumors (corresponding to stage D) had DNA histograms in the diploid range. ' Tribukait's data are in agreement with results of studies being conducted by my colleagues and me, which consist of a prospective and a retrospective arm. 29 In the prospective study, we attempt to measure DNA in fresh tissue and cell samples from carcinomas still confined to the prostate (stages A and B), whereas in the retrospective study (based on archival, paraffinembedded tissues and archival prostatic aspiration smears), the emphasis is on stages C and D prostatic carcinomas. Although the results are not final and the numbers of patients are still small (63 patients in the prospective study and 67 in the retrospective study), a trend seems to emerge that has not changed significantly with accrual of additional patients most prostatic carcinomas of stages A and B have a diploid DNA pattern (diploid:aneuploid ratio, 4:1), whereas most carcinomas of stages C and D are nondiploid (diploid:aneuploid ratio, 1:4). The correlation of ploidy patterns with histologic grading by Gleason's system was satisfactory only in poorly differentiated tumors (numerical values 5 to 9) that were, for the most part, aneuploid. In the prospective study, almost all patients who underwent prostatectomy for treatment of stage A or B carcinoma have had diploid-range tumors and excellent survival to date. What do these findings mean? Why do tumors in the diploid range behave differently from tumors that are not diploid? Do the immune defense mechanisms of the host recognize and hence provide better control of the proliferation of tumor cells that resemble normal than cells that have lost their identity? Could "diploid" tumors become aneuploid? The available evidence suggests that such an evolution usually does not occur. Could diploid tumors have a small, undetectable subpopulation of aneuploid tumor cells capable of overgrowing the diploid component and changing the behavior of the tumor? It has been shown that some tumors, such as some malignant lymphomas with an aggressive behavior pattern, may have a normal DNA content. In such tumors, substantial chromosomal abnormalities may occur in the form of balanced translocations, which may lead to activation of oncogenes. 30 The information on chromosomal makeup of prostatic carcinoma is scanty and does not shed light on this question. Nevertheless, an increased expression of ras oncogene p21 protein in prostatic cancer was recently correlated with the degree of tumor differentiation but unfortunately not with DNA content. 31 The changes in leukemias and lymphomas, however, may have little in common with carcinomas. The answers to these and many other questions about tumor behavior and host response to prostatic carcinoma are currently unknown. Because of the relatively scanty data available to date, a definitive conclusion in reference to the prognostic value of DNA measurements in prostatic cancer would be premature, but perhaps a hypothesis could be proposed based on our studies, Tribukait's data, and the current contribution by Winkler and co-workers. It seems reasonable to assume that most cancers still confined to the prostate are diploid; most of these tumors, possibly 80%, are unlikely to progress beyond the prostate during the lifetime of the patient. The relatively small proportion of early stage prostatic cancers that are nondiploid ab initio are likely to progress and spread beyond the prostate. Therefore, prostatic carcinomas in clinically advanced stages are generally nondiploid. Even in patients with clinically advanced stages of pros-
4 196 EDITORIAL Mayo Clin Proc, February 1988, Vol 63 tatic carcinoma, the minority with diploid-range tumors will have a considerably greater chance of either long-term survival or cure. This hypothesis is in agreement with the autopsy data cited at the onset, with the clinical data pertaining to the excellent results of treatment of stages A and B prostatic carcinomas, and with the data presented by Winkler and colleagues. Are we currently able to answer the hypothetical question raised before in reference to the need for treatment of stage A and possibly B prostatic carcinomas? Should the DNA content in these tumors be considered a dependable guide to the dilemma of whether to treat or not to treat the patient? Although it is entirely premature to offer definitive conclusions at this time, it may be safely stated that all tumors that are clearly not diploid must be treated. How to manage the diploid-range tumors is uncertain at this time because at least some of them will progress beyond the prostate. Distinguishing those diploid tumors that will progress from those that will not is an obvious task that lies ahead. In the interim, if an occult, incidentally discovered prostatic carcinoma has an unequivocal, clearly diploid DNA pattern, the decision "not to treat" may be somewhat easier to make under suitable clinical circumstances. Acknowledgment. I thank Dr. Selwyn Z. Freed, Chairman of the Department of Urology at Montefiore Medical Center, Albert Einstein College of Medicine, and his faculty for their participation in the project on prostatic carcinoma. Drs. Robert Wersto and Daniel Deitch assist with the prospective arm of this study. Dr. James B. Amberson, formerly an American Cancer Society Fellow at our institution and now in the Department of Pathology, Cornell University Medical School, is in charge of the retrospective arm of the study. Leopold G. Koss, M.D. Department of Pathology Montefiore Medical Center Albert Einstein College of Medicine Bronx, New York REFERENCES 1. Petersen RO: Urologie Pathology. Philadelphia, JB Lippincott Company, 1986, pp Huggins C, Hodges CV: Studies on prostatic cancer. I. The effect of castration, of estrogen and of androgen injection on serum phosphatases in metastatic carcinoma of the prostate. Cancer Res 1: , Wynder EL, Mabuchi K, Whitmore WF Jr: Epidemiology of cancer of the prostate. Cancer 28: , Oota K: Latent carcinoma of the prostate among the Japanese. Acta Un Int Cancr 17: , Koss LG, Woyke S, Olszewski W: Aspiration Biopsy: Cytologie Interpretation and Histologie Bases. New York, Igaku-Shoin, Foti AG, Cooper JF, Herschman H, Malvaez RR: Detection of prostatic cancer by solid-phase radioimmunoassay of serum prostatic acid phosphatase. N Engl J Med 297: , Vihko P, Kontturi M, Lukkarinen O, Ervasti J, Vihko R: Screening for carcinoma of the prostate: rectal examination, and enzymatic and radioimmunologic measurements of serum acid phosphatase compared. Cancer 56: , Stamey TA, Yang N, Hay AR, McNeal JE, Freiha FS, Redwine E: Prostate-specific antigen as a serum marker for adenocarcinoma of the prostate. N Engl J Med 317: , Cantrell BB, DeKlerk DP, Eggleston JC, Boitnott JK, Walsh PC: Pathological factors that influence prognosis in stage A prostatic cancer: the influence of extent versus grade. J Urol 125: , Culp OS, Meyer JJ: Radical prostatectomy in the treatment of prostatic cancer. Cancer 32: , Correa RJ Jr, Anderson RG, Gibbons RP, Mason JT: Latent carcinoma of the prostate why the controversy? J Urol 111: , Correa RJ Jr, Gibbons RP, Cummings KB, Mason JT: Total prostatectomy for stage B carcinoma of the prostate. J Urol 117: , Walsh PC, Jewett HJ: Radical surgery for prostatic cancer. Cancer 45: , Elder JS, Gibbons RP, Correa RJ Jr, Brennen GE: Efficacy of radical prostatectomy for stage A2 carcinoma of the prostate. Cancer 56: , Gleason DF, Mellinger GT, Veterans Administration Cooperative Urological Research Group: Prediction of prognosis for prostatic adenocarcinoma by combined histological grading and clinical staging. J Urol 111:58-64, Utz DC, Farrow GM: Pathologic differentiation and prognosis of prostatic carcinoma. JAMA 209: , Mostofi FK: Grading of prostatic carcinoma. Cancer Chemother Rep 59: , Murphy GP, Whitmore WF Jr: A report of the workshops on the current status of the histologic grading of prostate cancer. Cancer 44: , Esposti PL: Cytologie malignancy grading of prostatic carcinoma by transrectal aspiration biopsy: a five-year follow-up study of 469 hormone-treated patients. Scand J Urol Nephrol 5: , Koss LG: Analytical and quantitative cytology: a historical perspective. Anal Quant Cytol 4: , Koss LG: Diagnostic Cytology and Its Histopathologic Bases. Third edition. Philadelphia, JB Lippincott Company, 1979
5 Mayo Clin Proc, February 1988, Vol 63 EDITORIAL Hedley DW, Friedlander ML, Taylor IW, Rugg CA, Mus- 27. grove EA: Method for analysis of cellular DNA content of paraffin-embedded pathological material using flow cytometry. J Histochem Cytochem 31: , Hedley DW, Friedlander ML, Taylor IW, Rugg CA, Musgrove EA: DNA flow cytometry of paraffin-embedded tissue (letter to the editor). Cytometry 5:660,1984 Koss LG, Greenebaum E: Measuring DNA in human 29. cancer (editorial). JAMA 255: ,1986 Auer G, Zetterberg A: The prognostic significance of 30. nuclear DNA content in malignant tumors of breast, prostate, and cartilage. In Advances in Clinical Cytology. Vol 2. Edited by LG Koss, DV Coleman. New York, Masson Publishing USA, 1984, pp Tribukait B: Flow cytometry in surgical pathology and cytology of tumors of the genito-urinary tract. In Advances in Clinical Cytology. Vol 2. Edited by LG Koss, DV Coleman. New York, Masson Publishing USA, 1984, pp Tribukait B: Flow cytometry in assessing the clinical aggressiveness of genito-urinary neoplasms. World J Urol 5: ,1987 Stephenson RA, James BC, Gay H, Fair WR, Whitmore WF Jr, Melamed MR: Flow cytometry of prostate cancer: relationship of DNA content to survival. Cancer Res 47: ,1987 Koss LG: Objective cell parameters in prostatic carcinoma. Organ Systems Newslett 3:5-7, September 1987 Weiss LM, Warnke RA, Sklar J, Cleary ML: Molecular analysis of the t(14;18) chromosomal translocation in malignant lymphomas. N Engl J Med 317: , 1987 Viola MV, Fromowitz F, Oravez S, Deb S, Finkel G, Lundy J, Hand P, Thor A, Schlom J: Expression of ras oncogene p21 in prostate cancer. N Engl J Med 314: ,1986
Outcomes of Radical Prostatectomy in Thai Men with Prostate Cancer
Original Article Outcomes of Radical Prostatectomy in Thai Men with Prostate Cancer Sunai Leewansangtong, Suchai Soontrapa, Chaiyong Nualyong, Sittiporn Srinualnad, Tawatchai Taweemonkongsap and Teerapon
More informationASSESSMENT OF GLEASON SYSTEM USE ON DIFFERENT TYPES OF PROSTATIC TISSUE SAMPLES
ASSESSMENT OF GLEASON SYSTEM USE ON DIFFERENT TYPES OF PROSTATIC TISSUE SAMPLES I. E. PLEŞEA*, B. ZAHARIA*, S. D. ENACHE**, G. MITROI***, P. TOMESCU***, O. T. POP*, P. BADEA****, A. KOŻOKIĆ***** *Department
More informationTHE SIGNIFICANCE OF HYPOECHOIC LESION DIRECTED AND TRANSITION ZONE BIOPSIES IN IMPROVING THE DIAGNOSTIC ABILITY IN PROSTATE CANCER
Clinical Urology Brazilian Journal of Urology Official Journal of the Brazilian Society of Urology Vol. 27 (3): 222-226, May - June, 2001 THE SIGNIFICANCE OF HYPOECHOIC LESION DIRECTED AND TRANSITION ZONE
More informationPrognostic value of the Gleason score in prostate cancer
BJU International (22), 89, 538 542 Prognostic value of the Gleason score in prostate cancer L. EGEVAD, T. GRANFORS*, L. KARLBERG*, A. BERGH and P. STATTIN Department of Pathology and Cytology, Karolinska
More informationPercent Gleason pattern 4 in stratifying the prognosis of patients with intermediate-risk prostate cancer
Review Article Percent Gleason pattern 4 in stratifying the prognosis of patients with intermediate-risk prostate cancer Meenal Sharma 1, Hiroshi Miyamoto 1,2,3 1 Department of Pathology and Laboratory
More informationProstate cancer ~ diagnosis and impact of pathology on prognosis ESMO 2017
Prostate cancer ~ diagnosis and impact of pathology on prognosis ESMO 2017 Dr Puay Hoon Tan Division of Pathology Singapore General Hospital Prostate cancer (acinar adenocarcinoma) Invasive carcinoma composed
More informationOverview. What is Cancer? Prostate Cancer 3/2/2014. Davis A Romney, MD Ironwood Cancer and Research Centers Feb 18, 2014
Prostate Cancer Davis A Romney, MD Ironwood Cancer and Research Centers Feb 18, 2014 Overview Start with the basics: Definition of cancer Most common cancers in men Prostate, lung, and colon cancers Cancer
More informationSupplemental Information
Supplemental Information Prediction of Prostate Cancer Recurrence using Quantitative Phase Imaging Shamira Sridharan 1, Virgilia Macias 2, Krishnarao Tangella 3, André Kajdacsy-Balla 2 and Gabriel Popescu
More informationSince the beginning of the prostate-specific antigen (PSA) era in the. Characteristics of Insignificant Clinical T1c Prostate Tumors
2001 Characteristics of Insignificant Clinical T1c Prostate Tumors A Contemporary Analysis Patrick J. Bastian, M.D. 1 Leslie A. Mangold, B.A., M.S. 1 Jonathan I. Epstein, M.D. 2 Alan W. Partin, M.D., Ph.D.
More informationOutcomes Following Negative Prostate Biopsy for Patients with Persistent Disease after Radiotherapy for Prostate Cancer
Clinical Urology Post-radiotherapy Prostate Biopsy for Recurrent Disease International Braz J Urol Vol. 36 (1): 44-48, January - February, 2010 doi: 10.1590/S1677-55382010000100007 Outcomes Following Negative
More informationPREVALENCE OF PROSTATE CANCER AMONG HYPOGONADAL MEN WITH PROSTATE-SPECIFIC ANTIGEN LEVELS OF 4.0 ng/ml OR LESS
ADULT UROLOGY PREVALENCE OF PROSTATE CANCER AMONG HYPOGONADAL MEN WITH PROSTATE-SPECIFIC ANTIGEN LEVELS OF 4.0 ng/ml OR LESS ABRAHAM MORGENTALER AND ERNANI LUIS RHODEN ABSTRACT Objectives. To determine
More informationFlow Cytometric Determination of DNA Content in Renal Cell Carcinoma with Special Reference to Tumor Heterogeneity'
The Seoul Journal of Medicine Vol. 32, No. 3: 161-169, September 1991 Flow Cytometric Determination of DNA Content in Renal Cell Carcinoma with Special Reference to Tumor Heterogeneity' Sang Eun Leet2
More informationAlthough current American Cancer Society guidelines
ORIGINAL ARTICLE Diffuse Adenosis of the Peripheral Zone in Prostate Needle Biopsy and Prostatectomy Specimens Tamara L. Lotan, MD* and Jonathan I. Epstein, MD*w z Abstract: We have observed a group of
More informationRare Small Cell Carcinoma in Genitourinary Tract: Experience from E-Da Hospital
E-Da Medical Journal 20;():-5 Original Article Rare Small Cell Carcinoma in Genitourinary Tract: Experience from E-Da Hospital Wei-Ting Kuo, I-Wei Chang2, Kevin Lu, Hua-Pin Wang, Tsan-Jung u, Victor C.
More informationACCME/Disclosures. Cribriform Lesions of the Prostate. Case
Cribriform Lesions of the Prostate Ming Zhou, MD, PhD Departments of Pathology and Urology New York University Langone Medical Center New York, NY Ming.Zhou@NYUMC.ORG ACCME/Disclosures The USCAP requires
More informationCoordinate Expression of Cytokeratins 7 and 20 in Prostate Adenocarcinoma and Bladder Urothelial Carcinoma
Anatomic Pathology / CYTOKERATINS 7 AND 20 IN PROSTATE AND BLADDER CARCINOMAS Coordinate Expression of Cytokeratins 7 and 20 in Prostate Adenocarcinoma and Bladder Urothelial Carcinoma Nader H. Bassily,
More informationThe Prostate Specific-Antigen (PSA):
The Prostate Specific-Antigen (PSA): Why it could not detect prostate cancer reliably in the past and How it became a sensitive and specific tumor marker Hans H. Glaettli, dipl. Phys. ETH 0. Summary PSA
More informationCorrelation of Gleason Scores Between Needle-Core Biopsy and Radical Prostatectomy Specimens in Patients with Prostate Cancer
ORIGINAL ARTICLE Correlation of Gleason Scores Between Needle-Core Biopsy and Radical Prostatectomy Specimens in Patients with Prostate Cancer Teng-Fu Hsieh, Chao-Hsian Chang, Wen-Chi Chen, Chien-Lung
More informationperformed to help sway the clinician in what the appropriate diagnosis is, which can substantially alter the treatment of management.
Hello, I am Maura Polansky at the University of Texas MD Anderson Cancer Center. I am a Physician Assistant in the Department of Gastrointestinal Medical Oncology and the Program Director for Physician
More informationAcute: Symptoms that start and worsen quickly but do not last over a long period of time.
Cancer Glossary Acute: Symptoms that start and worsen quickly but do not last over a long period of time. Adjuvant therapy: Treatment given after the main treatment. It usually refers to chemotherapy,
More informationNPQR Quality Payment Program (QPP) Measures 21_18247_LS.
NPQR Quality Payment Program (QPP) Measures 21_18247_LS MEASURE ID: QPP 99 MEASURE TITLE: Breast Cancer Resection Pathology Reporting pt Category (Primary Tumor) and pn Category (Regional Lymph Nodes)
More informationBiochemistry of Cancer and Tumor Markers
Biochemistry of Cancer and Tumor Markers The term cancer applies to a group of diseases in which cells grow abnormally and form a malignant tumor. It is a long term multistage genetic process. The first
More informationMultiparameter Flow Cytometric Analysis of Colon Polyps
Multiparameter Flow Cytometric Analysis of Colon Polyps BARBARA F. BANNER, M.D., MARY S. CHACHO, M.D., DAVID L. ROSEMAN, M.D., AND JOHN S. COON, M.D., PH.D. Sixty-eight colonic polyps of various histologic
More informationINTRADUCTAL LESIONS OF THE PROSTATE. Jonathan I. Epstein
INTRADUCTAL LESIONS OF THE PROSTATE Jonathan I. Epstein Topics Prostatic intraepithelial neoplasia (PIN) Intraductal adenocarcinoma (IDC-P) Intraductal urothelial carcinoma Ductal adenocarcinoma High Prostatic
More informationPSA. HMCK, p63, Racemase. HMCK, p63, Racemase
Case 1 67 year old male presented with gross hematuria H/o acute prostatitis & BPH Urethroscopy: small, polypoid growth with a broad base emanating from the left side of the verumontanum Serum PSA :7 ng/ml
More informationRadical prostatectomy as radical cure of prostate cancer in a high risk group: A single-institution experience
MOLECULAR AND CLINICAL ONCOLOGY 1: 337-342, 2013 Radical prostatectomy as radical cure of prostate cancer in a high risk group: A single-institution experience NOBUKI FURUBAYASHI 1, MOTONOBU NAKAMURA 1,
More informationKEY WORDS : Total Prostate Specific Antigen, Prostatic Acid Phosphatase, Benign Prostatic Hyperplasia, Prostate Cancer, and Sudanese.
International Journal of Pharmaceutical Science Invention ISSN (Online): 2319 6718, ISSN (Print): 2319 670X Volume 3 Issue 1 January 2014 PP.36-40 Serum Total Prostatic Specific Antigen and Prostatic Acid
More informationElevated PSA. Dr.Nesaretnam Barr Kumarakulasinghe Associate Consultant Medical Oncology National University Cancer Institute, Singapore 9 th July 2017
Elevated PSA Dr.Nesaretnam Barr Kumarakulasinghe Associate Consultant Medical Oncology National University Cancer Institute, Singapore 9 th July 2017 Issues we will cover today.. The measurement of PSA,
More informationAFTER DIAGNOSIS: PROSTATE CANCER Understanding Your Treatment Options
AFTER DIAGNOSIS: PROSTATE CANCER Understanding Your Treatment Options INTRODUCTION This booklet describes how prostate cancer develops, how it affects the body and the current treatment methods. Although
More informationMast Cell Tumors in Dogs
Mast Cell Tumors in Dogs 803-808-7387 www.gracepets.com These notes are provided to help you understand the diagnosis or possible diagnosis of cancer in your pet. For general information on cancer in pets
More informationGUIDELINES ON PROSTATE CANCER
10 G. Aus (chairman), C. Abbou, M. Bolla, A. Heidenreich, H-P. Schmid, H. van Poppel, J. Wolff, F. Zattoni Eur Urol 2001;40:97-101 Introduction Cancer of the prostate is now recognized as one of the principal
More informationWhat Is Prostate Cancer? Prostate cancer is the development of cancer cells in the prostate gland (a gland that produces fluid for semen).
What Is Prostate Cancer? Prostate cancer is the development of cancer cells in the prostate gland (a gland that produces fluid for semen). It is a very common cancer in men; some cancers grow very slowly,
More informationReceived: 11 Feb. 2013; Accepted: 7 Jun. 2013
ORIGINAL REPORT Inter-Observer Reproducibility before and after Web-Based Education in the Gleason Grading of the Prostate Adenocarcinoma among the Iranian Pathologists Alireza Abdollahi 1*, Sara Sheikhbahaei
More informationISPUB.COM. Interpretation Of Prostatic Biopsies: A Review. A Chitale, S Khubchandani INTRODUCTION NON-NEOPLASTIC LESIONS GRADING: GLEASON'S SCORE
ISPUB.COM The Internet Journal of Urology Volume 3 Number 1 A Chitale, S Khubchandani Citation A Chitale, S Khubchandani.. The Internet Journal of Urology. 2004 Volume 3 Number 1. Abstract The incidence
More informationWhen to worry, when to test?
Focus on CME at the University of Calgary Prostate Cancer: When to worry, when to test? Bryan J. Donnelly, MSc, MCh, FRCSI, FRCSC Presented at a Canadian College of Family Practitioner s conference (October
More informationThe Royal Marsden. Prostate case study. Presented by Mr Alan Thompson Consultant Urological Surgeon
Prostate case study Presented by Mr Alan Thompson Consultant Urological Surgeon 2 Part one Initial presentation A 62 year old male solicitor attends your GP surgery. He has rarely seen you over the last
More informationWhat is Cancer? Understanding the basics of
What is Cancer? Understanding the basics of A process of physical and biological changes that occur when normal healthy cells are transformed into cancer cells What is Cancer? Cancer is an umbrella term
More informationSTUDY OF PROSTATIC LESION FOR A PERIOD OF FIVE YEARS
Page222 IJPBS Volume 4 Issue 2 APR-JUN 2014 222-226 Research Article Biological Sciences STUDY OF PROSTATIC LESION FOR A PERIOD OF FIVE YEARS B. Rajashekar Reddy 1, Rameswarapu Suman Babu 1 and Sujatha.P*
More informationPloidy Level Determinations in High-Grade and Low-Grade Malignant Variants of Prostatic Carcinoma1
(CANCER RESEARCH 50. 4281-4285. July 15. 1990] Ploidy Level Determinations in High-Grade and Low-Grade Malignant Variants of Prostatic Carcinoma1 Gun Forsslund and Anders Zetterberg2 Division of Tumor
More informationORIGINAL ARTICLE Nuclear morphometry and texture analysis on cytological smears of thyroid neoplasms: a study of 50 cases
Malaysian J Pathol 2017; 39(1) : 33 37 ORIGINAL ARTICLE Nuclear morphometry and texture analysis on cytological smears of thyroid neoplasms: a study of 50 cases Lopamudra DEKA MD, Shilpa GUPTA MD, Ruchika
More informationHigh-Dose Estrogen Therapy for Advanced Prostatic Cancer
Jpn. J. Clin. Oncol. 98, () ~ 8 High-Dose Estrogen Therapy for Advanced Prostatic Cancer KENKICHI KOISO, M.D., MIKINOBU OHTANI, M.D., HIROYUKI ASAKAGE, M.D., MAKOTO FUJIME, M.D., HIDEICHI AKIMA, M.D.,
More informationPreoperative Gleason score, percent of positive prostate biopsies and PSA in predicting biochemical recurrence after radical prostatectomy
JBUON 2013; 18(4): 954-960 ISSN: 1107-0625, online ISSN: 2241-6293 www.jbuon.com E-mail: editorial_office@jbuon.com ORIGINAL ARTICLE Gleason score, percent of positive prostate and PSA in predicting biochemical
More informationADENOCARCINOMA OF THE PROSTATE
Ref : ADENOCARCINOMA OF THE PROSTATE Div. of Urology, Dept. Surgery Medical Faculty, University of Sumatera Utara Clinical Manual of Urology, (Philip M. Hanno et al eds), McGraw-Hill Int ed, 3 rd ed, 2001
More informationA Study of Thyroid Swellings and Correlation between FNAC and Histopathology Results
International Journal of Current Microbiology and Applied Sciences ISSN: 2319-7706 Volume 6 Number 4 (2017) pp. 265-269 Journal homepage: http://www.ijcmas.com Original Research Article https://doi.org/10.20546/ijcmas.2017.604.030
More informationInsignificant Prostate Cancer in Radical Prostatectomy Specimen: TimeTrends and Preoperative Prediction
European Urology European Urology 43 (2003) 455 460 Insignificant Prostate Cancer in Radical Prostatectomy Specimen: TimeTrends and Preoperative Prediction Herbert Augustin a,b, Peter G. Hammerer a,c,*,
More informationTransurethral Prostatic Resection for Acute Urinary Retention in Patients with Prostate Cancer
ORIGINAL ARTICLE Transurethral Prostatic Resection for Acute Urinary Retention in Patients with Prostate Cancer Chang-Chi Chang, Junne-Yih Kuo*, Kuang-Kuo Chen, Alex Tong-Long Lin, Yen-Hwa Chang, Howard
More informationSignificance of Aneuploidy in Melanoma of the Extremity
Significance of Aneuploidy in elanoma of the xtremity. W. van Oven,.D.,*. C. Baas,.D.,t J. W. Oosferhuis,.D., h.d.,* H. Schraffordf Koops,.D., h.d.,t and A. Dameiring, B.S.* 09 Tumor nuclear DNA content
More informationIntraductal carcinoma of the prostate on needle biopsy: histologic features and clinical significance
& 2006 USCAP, Inc All rights reserved 0893-3952/06 $30.00 www.modernpathology.org Intraductal carcinoma of the prostate on needle biopsy: histologic features and clinical significance Charles C Guo 1 and
More informationThe Relation of Surgery for Prostatic Hypertrophy to Carcinoma of the Prostate
American Journal of Epidemiology Vol. 138, No. 5 Copyright C 1993 by The Johns Hopkins University School of Hygiene and Public Health Printed in U.SA. All rights reserved The Relation of Surgery for Prostatic
More informationAre Prostate Carcinoma Clinical Stages T1c and T2 Similar?
Clinical Urology Are Clinical Stages T1c and T2 Similar? International Braz J Urol Vol. 32 (2): 165-171, March - April, 2006 Are Prostate Carcinoma Clinical Stages T1c and T2 Similar? Athanase Billis,
More informationPathologic characteristics of prostatic adenocarcinomas: a mapping analysis of Korean patients
Pathologic characteristics of prostatic adenocarcinomas: a mapping analysis of Korean patients SY Song 1 *, SR Kim 1, G Ahn 1 & HY Choi 2 1 Department of Pathology, Sungkyunkwan University School of Medicine,
More informationChapter 2. Understanding My Diagnosis
Chapter 2. Understanding My Diagnosis With contributions from Nancy L. Brown, Ph.D.,Palo Alto Medical Foundation Research Institute; and Patrick Swift, M.D., Alta Bates Comprehensive Cancer Program o Facts
More informationGUIDELINEs ON PROSTATE CANCER
GUIDELINEs ON PROSTATE CANCER (Text update March 2005: an update is foreseen for publication in 2010. Readers are kindly advised to consult the 2009 full text print of the PCa guidelines for the most recent
More informationIn 2005, International Society of Urological Pathology
ORIGINAL ARTICLE Gleason Score 3+4=7 Prostate Cancer With Minimal Quantity of Gleason Pattern 4 on Needle Biopsy Is Associated With Low-risk Tumor in Radical Prostatectomy Specimen Cheng Cheng Huang, MD,*
More informationCellular Dyscohesion in Fine-Needle Aspiration of Breast Carcinoma Prognostic Indicator for Axillary Lymph Node Metastases?
natomic Pathology / PROGNOSTIC INDICTOR FOR XILLRY LYMPH NODE METSTSES Cellular Dyscohesion in Fine-Needle spiration of reast Carcinoma Prognostic Indicator for xillary Lymph Node Metastases? nne. Schiller,
More informationPost Radical Prostatectomy Adjuvant Radiation in Patients with Seminal Vesicle Invasion - A Historical Series
Post Radical Prostatectomy Adjuvant Radiation in Patients with Seminal Vesicle Invasion - A Historical Series E. Z. Neulander 1, K. Rubinov 2, W. Mermershtain 2, Z. Wajsman 3 1 Department of Urology, Soroka
More informationExpression of Oncogenic Antigen 519 (OA- 519) in Prostate Cancer Is a Potential Prognostic Indicator
ANATOMIC PATHOLOGY Original Article Expression of Oncogenic Antigen 519 (OA- 519) in Prostate Cancer Is a Potential Prognostic Indicator MAHAMMAD S. SHURBAJI, M.D., 1 " 2 FRANCIS P. KUHAJDA, M.D., 3 GARY
More informationProstate Cancer Case Study 1. Medical Student Case-Based Learning
Prostate Cancer Case Study 1 Medical Student Case-Based Learning The Case of Mr. Powers Prostatic Nodule The effervescent Mr. Powers is found by his primary care provider to have a prostatic nodule. You
More informationNormal Morphology. Anatomic Considerations. Normal Urothelial Histology and Cytology
1 Normal Morphology Anatomic Considerations The urinary tract can be divided into three regions: the kidney; the calyces, pelves and ureters (upper collecting system or upper tract); and the bladder and
More informationPercentage of Gleason Pattern 4 and 5 Predicts Survival After Radical Prostatectomy
1967 Percentage of Gleason Pattern 4 and 5 Predicts Survival After Radical Prostatectomy Liang Cheng, MD 1,2 Darrell D. Davidson, MD, PhD 1 Haiqun Lin, MD, PhD 3 Michael O. Koch, MD 2 1 Department of Pathology
More information-The cause of testicular neoplasms remains unknown
- In the 15- to 34-year-old age group, they are the most common tumors of men. - include: I. Germ cell tumors : (95%); all are malignant. II. Sex cord-stromal tumors: from Sertoli or Leydig cells; usually
More informationTHE incidence of cancer of the prostate gland among men who have symptoms
PROSTATE GLAND BIOPSY EUGENE F. POUTASSE, Department of Urology M.D. THE incidence of cancer of the prostate gland among men who have symptoms of bladder neck obstruction is about one out of five. The
More informationANATOMICAL PATHOLOGY TARIFF
ANATOMICAL PATHOLOGY TARIFF A GUIDE TO UTILISATION. The following guidelines have been agreed by consensus of Anatomical Pathologists who are members of the Anatomical Pathologist s Group, or the National
More informationHyperplastic, Premalignant and Malignant Lesions of the Prostate Gland
Jehoram Tei Anim, md, FRCPath; Sitara Abdul Sathar, MB; Mohammed Ejaz Bhatti, MSc From the Department of Pathology, Faculty of Medicine, Kuwait University, Kuwait. Address reprint requests and correspondence
More informationP rare and, therefore, their histopathologic
PROSTATIC ADENOCARCINOMA OF DUCTAL ORIGIN VOLKER E. DUBE, MD,+ GEORGE M. FARROW, AND LAURENCE F. GREENE, MD+ MD+ Clinical and histopathologic features of prostatic ductal adenocarcinomas have been incompletely
More informationLOCALIZED PROSTATIC CANCER IN PATIENTS SUBMITTED TO RENAL TRANSPLANT
Clinical Urology International Braz J Urol Official Journal of the Brazilian Society of Urology Vol. 28 (4): 330-334, July - August, 2002 LOCALIZED PROSTATIC CANCER IN PATIENTS SUBMITTED TO RENAL TRANSPLANT
More informationReview of Clinical Manifestations of Biochemicallyadvanced Prostate Cancer Cases
Original Article Review of Clinical Manifestations of Biochemicallyadvanced Prostate Cancer Cases Edmund Chiong, 1,2 Alvin Fung Wean Wong, 2 Yiong Huak Chan 3 and Chong Min Chin, 1,2 1 Department of Surgery,
More informationIncidence of Surgically Treated Benign Prostatic Hypertrophy and of Prostate Cancer among Blacks and Whites in a Prepaid Health Care Plan
American Journal of EpKtermotogy Vo! 134, No 8 Copyright C 1991 by The Johns Hopkrts Uruversfty School of Hygiene and Put*: Health Printed in US A AS rights reserved A BRIEF ORIGINAL CONTRIBUTION Incidence
More informationMetachronous anterior urethral metastasis of prostatic ductal adenocarcinoma
http://dx.doi.org/10.7180/kmj.2016.31.1.66 KMJ Case Report Metachronous anterior urethral metastasis of prostatic ductal adenocarcinoma Jeong Hyun Oh 1, Taek Sang Kim 1, Hyun Yul Rhew 1, Bong Kwon Chun
More informationBY Mrs. K.SHAILAJA., M. PHARM., LECTURER DEPT OF PHARMACY PRACTICE, SRM COLLEGE OF PHARMACY
BY Mrs. K.SHAILAJA., M. PHARM., LECTURER DEPT OF PHARMACY PRACTICE, SRM COLLEGE OF PHARMACY Cancer is a group of more than 100 different diseases that are characterized by uncontrolled cellular growth,
More informationMammary Tumors. by Pamela A. Davol
Mammary Tumors by Pamela A. Davol Malignant tumors of the mammary glands occur with a higher incident than any other form of cancer in female dogs. Additionally, evidence suggests that females with benign
More informationThe Prognostic Importance of Prostate-Specific Antigen in Monitoring Patients Undergoing Maximum Androgen Blockage for Metastatic Prostate Cancer
Research Article TheScientificWorldJOURNAL (005) 5, 8 4 ISSN 57-744X; DOI 0.00/tsw.005.9 The Prognostic Importance of Prostate-Specific Antigen in Monitoring Patients Undergoing Maximum Androgen Blockage
More informationresponse of PCa to testosterone deprivation in the early 1940s, testosterone has been considered as fuel to the fire of PCa.
BJUI BJU INTERNATIONAL Low testosterone levels are related to poor prognosis factors in men with prostate cancer prior to treatment Eduardo Garc í a-cruz, Marta Piqueras, Jorge Huguet, Lluis Peri, Laura
More informationWhat s New in Pathology of Genitourinary Tumors. Jiaoti Huang, MD, PhD Department of Pathology Duke University School of Medicine
What s New in Pathology of Genitourinary Tumors Jiaoti Huang, MD, PhD Department of Pathology Duke University School of Medicine Kidney Tumors Multilocular cystic renal neoplasm of low malignant potential
More informationProstate Overview Quiz
Prostate Overview Quiz 1. The path report reads: Gleason 3 + 4 = 7. The Gleason s score is a. 3 b. 4 c. 7 d. None of the above 2. The path report reads: Moderately differentiated adenocarcinoma of the
More informationTHE PROSTATE. SMALL GLAND BIG PROBLEM By John Crow. Chapter 4
THE PROSTATE SMALL GLAND BIG PROBLEM By John Crow Chapter 4 In this chapter I want to address the big issue CANCER. What is CANCER? As you will already know, our body tissue is made up of literally Billions
More informationCytological evaluation of effusion fluid with cell block technique and cytology smears among Sudanese patients
EUROPEAN ACADEMIC RESEARCH Vol. IV, Issue 3/ June 2016 ISSN 2286-4822 www.euacademic.org Impact Factor: 3.4546 (UIF) DRJI Value: 5.9 (B+) Cytological evaluation of effusion fluid with cell block technique
More informationNeoplasia 2018 lecture 11. Dr H Awad FRCPath
Neoplasia 2018 lecture 11 Dr H Awad FRCPath Clinical aspects of neoplasia Tumors affect patients by: 1. their location 2. hormonal secretions 3. paraneoplastic syndromes 4. cachexia Tumor location Even
More informationROLE OF PROSTATIC BASAL CELL MARKER IN DIAGNOSIS OF PROSTATIC LESIONS
Original Research Article Pathology International Journal of Pharma and Bio Sciences ISSN 0975-6299 ROLE OF PROSTATIC BASAL CELL MARKER IN DIAGNOSIS OF PROSTATIC LESIONS SUBATHRA K* Department of pathology,
More informationDuctal adenocarcinoma of the prostate: A clinicopathological study
20 B. SATHESAN, S. A. S. GOONEWARDENA, H. W. D. ANURUDDHIKA AND M. V. C. DE SILVA Sri Lanka Journal of Urology, 2008, 9, 20-24 Original Article Ductal adenocarcinoma of the prostate: A clinicopathological
More informationProstate-Specific Antigen (PSA) Test
Prostate-Specific Antigen (PSA) Test What is the PSA test? Prostate-specific antigen, or PSA, is a protein produced by normal, as well as malignant, cells of the prostate gland. The PSA test measures the
More informationof Nebraska - Lincoln
University of Nebraska - Lincoln DigitalCommons@University of Nebraska - Lincoln U.S. Department of Veterans Affairs Staff Publications U.S. Department of Veterans Affairs 8-2000 Detection, Characterization,
More informationTHE DILEMMA OF PROSTATE CANcer
ORIGINAL CONTRIBUTION Biological Determinants of Cancer Progression in Men With Prostate Cancer Thomas A. Stamey, MD John E. McNeal, MD Cheryl M. Yemoto Bronislava M. Sigal, PhD Iain M. Johnstone, PhD
More informationRubin H. Flocks and Colloidal Gold Treatments for Prostate Cancer
Research Article TheScientificWorldJOURNAL (2011) 11, 1560 1567 ISSN 1537-744X; DOI 10.1100/tsw.2011.145 Rubin H. Flocks and Colloidal Gold Treatments for Prostate Cancer Henry M. Rosevear 1, Andrew J.
More informationInvasion of the muscular wall of the seminal vesicles by prostate cancer is generally
PROSTATE CANCER Seminal Vesicle Invasion by Prostate Cancer: Prognostic Significance and Therapeutic Implications Steven R. Potter, MD,* Jonathan I. Epstein, MD,* Alan W. Partin, MD, PhD* *The James Buchanan
More informationBIT 120. Copy of Cancer/HIV Lecture
BIT 120 Copy of Cancer/HIV Lecture Cancer DEFINITION Any abnormal growth of cells that has malignant potential i.e.. Leukemia Uncontrolled mitosis in WBC Genetic disease caused by an accumulation of mutations
More informationSome prostatic diseases
Some prostatic diseases Benign Prostatic Hyperplasia (Nodular Hyperplasia) Extremely common Present in a significant number of men by the age of 40 & its frequency rises progressively with age, reaching
More informationInstitute for Cancer Genetics and Informatics
Organization Institute for Cancer Genetics and Informatics Annual Report 217 The Institute for Cancer Genetics and Informatics, ICGI, is a department at Oslo University Hospital (OUS), located at the Norwegian
More informationNeoplasia part I. Dr. Mohsen Dashti. Clinical Medicine & Pathology nd Lecture
Neoplasia part I By Dr. Mohsen Dashti Clinical Medicine & Pathology 316 2 nd Lecture Lecture outline Review of structure & function. Basic definitions. Classification of neoplasms. Morphologic features.
More informationAnatomic distribution and pathologic characterization of small-volume prostate cancer (o0.5 ml) in whole-mount prostatectomy specimens
& 2005 USCAP, Inc All rights reserved 0893-3952/05 $30.00 www.modernpathology.org Anatomic distribution and pathologic characterization of small-volume prostate cancer (o0.5 ml) in whole-mount prostatectomy
More informationConcurrent Multilocular Cystic Renal Cell Carcinoma and Leiomyoma in the Same Kidney: Previously Unreported Association
218 Concurrent Multilocular Cystic Renal Cell Carcinoma and Leiomyoma in the Same Kidney: Previously Unreported Association Min Su Cheong a Dong Hun Koo a In-Sung Kim a Kyung Chul Moon b Ja Hyeon Ku a
More informationPost Radical Prostatectomy Radiation in Intermediate and High Risk Group Prostate Cancer Patients - A Historical Series
Post Radical Prostatectomy Radiation in Intermediate and High Risk Group Prostate Cancer Patients - A Historical Series E. Z. Neulander 1, Z. Wajsman 2 1 Department of Urology, Soroka UMC, Ben Gurion University,
More informationProstate Pathology: Prostate Carcinoma, variants and Gleason Grading (Part 1)
Prostate Pathology: Prostate Carcinoma, variants and Gleason Grading (Part 1) Jae Y. Ro, MD, PhD June 7, 2012 Ten Leading Cancer Types for the Estimated New Cancer Cases and Deaths By Sex, United States,
More information1. Q: What has changed from the draft recommendations posted for public comment in November/December 2011?
Frequently Asked Questions (FAQs) in regard to Molecular Testing Guideline for Selection of Lung Cancer Patients for EGFR and ALK Tyrosine Kinase Inhibitors 1. Q: What has changed from the draft recommendations
More informationA Competing Risk Analysis of Men Age Years at Diagnosis Managed Conservatively for Clinically Localized Prostate Cancer
A Competing Risk Analysis of Men Age 55-74 Years at Diagnosis Managed Conservatively for Clinically Localized Prostate Cancer Peter C. Albertsen, MD 1 James A. Hanley, PhD 2 Donald F.Gleason, MD, PhD 3
More informationAge-specific reference ranges for prostate-specific antigen (PSA) in Jordanian patients
(2003) 6, 256 260 & 2003 Nature Publishing Group All rights reserved 1365-7852/03 $25.00 www.nature.com/pcan Age-specific reference ranges for prostate-specific antigen (PSA) in Jordanian patients 1, *
More informationEfficacy of FNAC in early diagnosis of prostatic carcinoma
Original Research Article Efficacy of FNAC in early diagnosis of prostatic carcinoma S. Dhanraj Reddy 1*, M. Sandhya Rani 1 1 Associate Professor, Department of Pathology, MNR Medical College and Hospital,
More informationProstate Cancer Screening Guidelines in 2017
Prostate Cancer Screening Guidelines in 2017 Pocharapong Jenjitranant, M.D. Division of Urology, Department of Surgery, Faculty of Medicine, Ramathibodi Hospital Prostate Specific Antigen (PSA) Prostate
More informationDifferentiation of Tumors with Specific Red Cell Adherence (SRCA) test
753 Differentiation of Tumors with Specific Red Cell Adherence (SRCA) test Dr. Abhishek A Mangaonkar *, Dr. A G Valand 1 Intern, Grant Medical College and Sir J.J. Group of Hospitals, Mumbai, India 2 Professor,
More informationKidney, Bladder and Prostate Neoplasia. David Bingham MD
Kidney, Bladder and Prostate Neoplasia David Bingham MD typical malignant cytology of bladder washings 1 benign 2 malignant typical malignant cytology of bladder washings b Bladder tumor Non invasive papillary
More information