9. Richie, J.P., Jr. (1989) Antioxidants and the free radical theory of aging. Assoc. Anthropol. Gerontol. Newsletter 10:4-5.

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1 John Richie, Ph.D. All Publications 1. Richie, J.P., Jr., Mills, B.J., and Lang, C.A. (1984) The verification of a mammalian toxicant classification using a mosquito screening. Fundam. Appl. Toxicol. 4: Richie, J.P., Jr., and Lang, C.A. (1985) Aging effects on acetaminophen toxicity and glutathione status in the mosquito. Drug Metab. Dispos. 13: Richie, J.P., Jr., Mills, B.J., and Lang, C.A. (1986) Dietary nordihydroguaiaretic acid increases the life span of the mosquito. Proc. Soc. Exp. Biol. Med. 183: Lang, C.A., and Richie, J.P., Jr. (1986) Biogerontological precepts of Nathan Shock which influenced our aging research. Exp. Gerontol. 21: Richie, J.P., Jr., Mills, B.J., and Lang, C.A. (1987) Correction of a glutathione deficiency in the aging mosquito increases its longevity. Proc. Soc. Exp. Biol. Med. 184: Richie, J.P., Jr., and Lang, C.A. (1987) The determination of glutathione, cyst(e)ine, and other thiols and disulfides in biological samples using high performance liquid chromatography with dual electrochemical detection. Anal. Biochem. 163: Richie, J.P., Jr., and Lang, C.A. (1988) A decrease in cysteine levels causes the glutathione deficiency of aging in the mosquito. Proc. Soc. Exp. Biol. Med. 187: Chen, T.S., Richie, J.P., Jr., and Lang, C.A. (1989) The effect of aging on glutathione and cysteine levels in different regions of the mouse brain. Proc. Soc. Exp. Biol. Med. 190: Richie, J.P., Jr. (1989) Antioxidants and the free radical theory of aging. Assoc. Anthropol. Gerontol. Newsletter 10: Mills, B.J., Richie, J.P., Jr., and Lang, C.A. (1990) Sample processing alters the values of glutathione and cysteine in blood. Anal. Biochem. 184: Chen, T.S., Richie, J.P., Jr., and Lang, C.A. (1990) Life span profiles of glutathione and acetaminophen detoxification. Drug Metab. Dispos. 18: Forinash, K., Richie, J.P., Jr., and Jones, T. (1990) Wind Chimes Phys. Am. J. Physiol. 58:82-83.

2 13. Richie, J.P., Jr., and Williams, G.M. (1991) Aging and Cancer. In The Potential for Nutritional Modulation of Aging Processes (Ingram, D.K. et al., eds.), Food and Nutrition Press: Westport, CT, pp Richie, J.P., Jr., Leutzinger, Y., Axelrad, C.M., and Haley, N.J. (1991) Contribution of trans-3'-hydroxycotinine and glucuronide conjugates of nicotine metabolites to the measurement of cotinine by RIA. In Effects of Nicotine on Biological Systems (Adlkofer, F., and Thurau, K., eds.), Birkhauser Verlag: Basel, pp Hebert, J.R., Miller, D.R., Barone, J., and Richie, J.P., Jr. (1991) Erythrocyte membrane fatty acids and natural killer cell activity in a longitudinal intervention trial. Immunol. Infec. Dis. 1: Richie, J.P., Jr. (1991) The role of nutrition in cancer of the oral cavity. J. Appl. Nutr. 43(1): Richie, J.P., Jr. (1992) Prevention of chronic diseases and promotion of longevity: the current challenges of nutritional research. J. Optimal Nutr. 1(1): Richie, J.P., Jr., Lang, C.A., and Chen, T.S. (1992) Acetaminophen-induced depletion of glutathione and cysteine in the aging mouse kidney. Biochem. Pharmacol. 44: Richie, J.P., Jr. (1992) The role of glutathione in aging and cancer. Exp. Gerontol. 27: Vogt, B.L., and Richie, J.P., Jr. (1993) Fasting-induced depletion of glutathione in the aging mouse. Biochem. Pharmacol. 46: Sohn, O.S., Surace, A., Fiala, E.S., Richie, J.P., Jr., Colosimo, S., Zang, E., and Weisburger, J.H. (1994) Effects of green and black tea on hepatic xenobiotic metabolizing systems in the male F344 rat. Xenobiotica 24(2): Mills, B.J., Richie, J.P., Jr., and Lang, C.A. (1994) Glutathione disulfide variability in normal human blood. Anal. Biochem. 222: Richie, J.P., Jr., Leutzinger, Y., Parthasarathy, S., Malloy, V., Orentreich, N., and Zimmerman, J.A. (1994) Methionine restriction increases blood glutathione and longevity in F344 rats. FASEB J. 8: Lazarus, P., Garewal, H.S., Sciubba, J., Zwiebel, N., Calcagnotto, A., and Richie, J.P., Jr. (1995) A low incidence of p53 mutations in pre-malignant lesions of the oral cavity from non-tobacco users. Int. J. Cancer 60: Carmella, S.G., Akerkar, S.A., Richie, J.P., Jr., and Hecht, S.S. (1995) Intraindividual and interindividual differences in metabolites of the tobacco-specific lung carcinogen 4- (methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK) in smokers's urine. Cancer Epidemiol. Biomark. Prev. 4: Kleinman, W.A., and Richie, J.P., Jr. (1995) Determination of thiols and disulfides using high-performance liquid chromatography with electrochemical detection. J. Chromatogr. 672:73-80.

3 27. Leutzinger, Y., and Richie, J.P., Jr. (1995) The effect of animal age on tumor induction. In Chemical Induction of Cancer (Arcos, J.C., ed.), Birkhäuser: Boston, pp Hecht, S.S., Chung, F.-L., Richie, J.P., Jr., Akerkar, S.A., Borukhova, A., Skowronski, L., and Carmella, S.G. (1995) Effects of watercress consumption on metabolism of a tobacco-specific lung carcinogen in smokers. Cancer Epidemiol. Biomark. Prev. 4: Richie, J.P., Jr., Skowronski, L., Abraham, P., and Leutzinger, Y. (1996) Blood glutathione concentrations in a large-scale human study. Clin. Chem. 42: Lazarus, P., Stern, J., Zwiebel, N., Fair, A., Richie, J.P., Jr., and Schantz, S. (1996) Relationship between p53 mutation incidence in oral cavity squamous cell carcinomas and patient tobacco use. Carcinogenesis 17: Richie, J.P., Jr., Abraham, P., and Leutzinger, Y. (1996) Long-term stability of blood glutathione and cysteine in humans. Clin. Chem. 42: Muscat, J.E., Richie, J.P., Jr., Thompson, S., and Wynder, E.L. (1996) Gender differences in smoking and risk for oral cancer. Cancer Res. 56: Richie, J.P., Jr., Carmella, S.G., Muscat, J.E., Scott, D.G., Akerkar, S.A., and Hecht, S.S. (1997) Differences in the urinary metabolites of the tobacco-specific lung carcinogen 4- (methylnitrosamino)-1-(3-pyridyl)-1-butanone in black and white smokers. Cancer Epidemiol. Biomark. Prev. 6: Park, J.Y., Muscat, J.E., Ren, Q., Schantz, S.P., Harwick, R.D., Stern, J.C., Pike V., Richie, J.P., Jr., and Lazarus, P. (1997) CYP1A1 and GSTM1 polymorphisms and oral cancer risk. Cancer Epidemiol. Biomark. Prev. 6: El-Bayoumy, K., Chung, F.-L., Richie, J.P., Jr., Reddy, B.S., Cohen, L., Weisburger, J., and Wynder, E.L. (1997) Dietary control of cancer. Proc. Soc. Exp. Biol. Med. 216: Nath, R.G., Ocando, J.E., Richie, J.P., Jr., and Chung, F.-L. (1997) Effect of glutathionedepletion on exocyclic adduct levels in the liver DNA of F344 rats. Chem. Res.Toxicol. 10: Muscat, J.E., Stellman, S., Richie, J.P., Jr. and Wynder, E.L. (1998) Lung cancer risk and workplace exposures in black men and women. Environ. Res. 76: Zhao, Z., Khachik, F., Richie, J.P., Jr., and Cohen, L.A. (1998) Lycopene uptake and tissue disposition in male and female rats. Proc. Soc. Exp. Biol. Med. 218: Lazarus, P., Sheikh, S.N., Ren, Q., Schantz, S.P., Stern, J.C., Richie, J.P., Jr., and Park, J.Y. (1998) p53, but not p56 mutations in oral squamous cell carcinomas are associated with specific CYP1A1 and GSTM1 polymorphic genotypes and patient tobacco use. Carcinogenesis 19:

4 40. Whysner, J., Steward 3rd, R.E., Chen, D., Conaway, C.C., Verna, L.K., Richie, J.P., Jr., Ali, N., and Williams, G.M. (1998) Formation of 8-oxodeoxyguanosine in brain DNA of rats exposed to acrylonitrile. Arch. Toxicol. 72: Kaur, T.B., Travaline, J.M., Gaughan, J.P., Richie, J.P., Jr., Stellman, S.D., and Lazarus, P. (2000) Role of polymorphisms in codons 143 and 160 of the O 6 -alkyguanine DNA alkyltransferase gene in lung cancer risk. Cancer Epidemiol. Biomark. Prev. 9: Park, J.Y., Muscat, J.E., Kaur, T., Schantz, S.P., Stern, J.C., Richie, J.P., Jr., and Lazarus, P. (2000) Comparison of GSTM polymorphisms and risk for oral cancer between African-Americans and Caucasians. Pharmacogenetics 10: Kleinman, W.A., and Richie, J.P., Jr. (2000) Status of glutathione and other thiols and disulfides in human plasma. Biochem. Pharmacol. 60: Chen, T.S., Richie, J.P., Jr., Nagasawa, H.T. and Lang, C.A. (2000) Glutathione monoethyl ester protects against glutathione deficiencies due to aging and acetaminophen in mice. Mech. Age. Dev. 120: Hurt, R.D., Croghan, G.A., Wolter, T.D., Croghan, I.T., Offord, K.P., Williams, G.M., Djordjevic, M.V., Richie, J.P., Jr. and Jeffrey, A.M. (2000) Does smoking reduction result in reduction of biomarkers associated with harm? A pilot study using a nicotine inhaler. Nicotine and Tobacco Research 2: El-Bayoumy, K., Richie, J.P., Jr., Boyiri, T., Komninou, D., Kleinman, W.A., Cox, J., Pittman, B., and Colosimo, S. (2002) Influence of selenium-enriched yeast supplementation on biomarkers of oxidative damage and hormone status in healthy adult males: a clinical pilot study. Cancer Epidemiol. Biomark. Prev. 11: Muscat, J.E., Richie, J.P., Jr., and Stellman, S.D. (2002) Mentholated cigarettes and smoking habits in whites and blacks. Tobacco Control 11: Lang, C.A., Mills, B.J., Lang, H.L., Liu, M.C., Usui, W.M., Richie, J.P., Jr., Mastropaolo, W. and Murrell, S.A. (2002) High blood glutathione levels accompany excellent physical and mental health in women ages 60 to103 years. J. Lab. Clin. Med. 140: Kleinman, W.A., Komninou, D., Leutzinger, Y., Colosimo, S., Cox, J., Lang, C.A., and Richie, J.P., Jr. (2003) Protein glutathiolation in human blood. Biochem. Pharmacol. 65: Muscat, J., Chen, S., Richie, J.P., Jr., Altorki, N., Citron, M., Olson, S., Neugut, A., and Stellman, S.D. (2003) Risk of lung carcinoma among users of nonsteroidal antiinflammatory drugs. Cancer 97: Komninou, D., Ayonote, A., Richie, J.P., Jr., and Rigas, B. (2003) Insulin resistance and its contribution to colon carcinogenesis. Exp. Biol. Med. 228: Stellman, S.D., Chen, Y., Muscat, J.E., Djordevic, M.V., Richie, J.P., Jr., Lazarus, P., Thompson, S., Altorki, N., Berwick, M., Citron, M.L., Kaur, T.B., Neugut, A.I., Olson, S., Travaline, J.M., Witorsch, P., Zhang, Z.F. (2003) Lung cancer risk in white and black americans. Ann. Epidemiol. 13(4):

5 53. Elahi, A., Bendaly, J., Zheng, Z., Muscat, J.E., Richie, J.P. Jr., Schantz, SP, Lazarus, P. (2003) Detection of UGT1A10 polymorphisms and their association with orolaryngeal carcinoma risk. Cancer 98(4): Muscat, J.E., Kleinman, W, Colosimo, S., Muir, A., Lazarus, P., Park, J., and Richie, J.P., Jr. (2004) Enhanced protein glutathiolation and oxidative stress in cigarette smokers. Free Radical Biol. Med. 36: Richie, J.P., Jr., Komninou, D., Leutzinger, Y., Kleinman, W., Orentreich, N., Malloy, V., and Zimmerman, J.A. (2004) Tissue glutathione and cysteine levels in methionine restricted rats. Nutrition, 20: Chung, F-L., Komninou, D., Zhang, L., Nath, R., Pan, J., Amin, S. and Richie, J. (2005) Glutathione depletion enhances the formation of endogenous cyclic DNA adduct derived from t-4-hydroxy-2-nonenal in rat liver. Chem. Res. Toxicol. 18: Muscat, J., Djordjevic, M.V., Stellman, S.D., Stephenson, G., Cox, J. and Richie, Jr. J.P. (2005) Racial Differences in Exposure and Glucuronidation of the Tobacco-Specific Carcinogen 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK). Cancer 103: Rundle, A., Orjuela, M., Tang, D., Kim, M., Calcagnotto, A., Richie, J.P., Jr., Perera, F. (2005) Moderate physical activity is associated with increased blood levels of glutathione among smokers. Biomarkers 10: Komninou, D., Leutzinger Y., Reddy,B.S. and Richie, J.P., Jr. (2006) Methionine Restriction Inhibits Colon Carcinogenesis. Nutr. Cancer 54: Richie, J.P., Jr., Kleinman, W., Desai, D.H., Das, A. Amin, S.G., Pinto. J.T. and El- Bayoumy, K. (2006) The Organoselenium Compound 1,4-Phenylenebis(methylene)- selenocyanate Inhibits 4-(Methylnitrosamino)-1-(3-pyridyl)-1-butanone-induced tumorgenesis and enhances glutathione-related antioxidant levels in A/J mouse lung. Chem. Biol. Int. 161: Huang, Z., Komninou, D., Kleinman, W., Pinto, J.T., Gilhooly, E.M., Calcagnotto, A., and Richie, J.P., Jr. (2006) Enhanced levels of Glutathione and Protein Glutathiolation in Rat Tongue Epithelium During 4-NQO-induced Carcinogenesis. Int. J. Cancer 120: Gallagher CJ, Muscat JE, Hicks AN, Zheng Y, Dyer A-M, Chase GA, Richie JP Jr, Lazarus P. (2006) The UDP-glucuronosyltransferase 2B17 gene deletion polymorphism: Sexspecific association with urinary NNAL glucuronidation phenotype and risk for lung cancer. Cancer Epideiol. Biomark. Prev. (in press). 63. Richie, J.P., Jr., Komninou, D. and Albino, A. (2007) Induction of colon tumorigenesis by glutathione depletion in p53-knockout mice. Int. J. Oncology (in press). 64. Vogt, B.L. and Richie, J.P., Jr. (2007) Glutathione depletion and recovery after acute ethanol administration in the aging mouse. Biochem. Pharmacol. 73:

6 65. Melikian, A.A., Djordjevic, M.V., Chen, S., Richie, J. Jr. and Stellman, S.D. (2007) Effect of delivered dosage of cigarette smoke toxins on the levels of urinary biomarkers of exposure. Cancer Epidemiol. Biomarkers Prev. 16: Huang, Z., Pinto, J.T., Deng, H., and Richie, J.P., Jr. (2007) Inhibition of caspase-3 activity and activation by protein glutathionylation. Biochem. Pharm. 75: Richie J.P., Jr., Kleinman, W., Marina, P., Abraham, P., Wynder,,E.L., and Muscat, J.E. (2008) Blood iron, glutathione and micronutrient levels and the risk of oral cancer and premalignancy. Nutr. Cancer (in press). 68. Nichenametla, S.N., Ellison, I., Calcagnotto, A., Lazarus, P., Muscat, J.E., and Richie, J.P., Jr. (2008) Functional significance of the GAG trinucleotide-repeat polymorphism in the gene for the catalytic subunit of -glutamylcysteine ligase. Free Radic. Biol. Med. (in press). 69. Muscat, J.E., Pitman, B., Kleinman, W., Lazarus, P., Stellman, S.D., and Richie, J.P., Jr. Comparison of CYP1A2 and NAT2 phenotypes between black and white smokers. Biochem. Pharm. 76:929-37, PMCID: PMC [Available on 2009/10/01] 70. Gallagher, C., Ahn K, Knipe, A., Dyer, A-M, Richie, J.P., Jr., Lazarus, P., and Muscat, J.E. Association of haplotypes of manganese superoxide dismutase (SOD2), smoking and lung cancer risk. Free Radic. Biol. Med. 46:20-24, PMCID: PMC [Available on 2010/01/01] 71. Muscat, J.E., Gang, C., Knipe, A, Stellman, S.D., Lazarus, P. and Richie, J.P., Jr. Effects of menthol and tobacco exposure, nicotine dependence, and NNAL glucuronidation in black and white smokers. Cancer Epidemiol. Biomarkers Prev. 18:35-41, Wilson RT, Wang J, Chinchilli V, Richie JP, Jr., Virtamo, J., Moore, L.E., Albanes, D. Fish, vitamin D, and flavonoids in relation to renal cell cancer among smokers. Am J Epidemiol. 170:717-29, Chen K-M, Sacks PG, Spratt TE, Lin J-M, Boyiri T, Schwartz J, Richie JP, Jr., Calcagnotto, A., Das, A., Bortner, J., Zhao, Z., Amin, S., Guttenplan, J., El-Bayoumy, K. Modulations of benzo[a]pyrene-induced DNA adduct, cyclin D1 and PCNA in oral tissue by 1,4-phenylenebis(methylene)selenocyanate. Biochem. Biophys. Res. Commun. 22:383:151-5, PMCID: PMC Muscat JE, Chen G, Knipe A, Stellman SD, Lazarus P, Richie JP, Jr. Effects of menthol on tobacco smoke exposure, nicotine dependence and NNAL glucuronidation. Cancer Epidemiol. Biomarkers Prev. 18:35-41, PMCID: PMC Manni A, Xu H, Washington S, Aliaga C, Cooper T, Richie J, et al. The impace of fish oil on the chemopreventive efficacy of tamoxifen against development of N-methyl-Nnitrosourea (MNU)-induced rat mammary carcinogenesis. Cancer Prev. Res. 3:322-30, Muscat JE, Stellman SD, Caraballo R, Richie JP, Jr. Time to first cigarette after waking predicts cotinine levels. Cancer Epidemiol. Biomarkers Prev. 18: , 2009

7 77. Rundle, A., Richie, J., Steindorf, K.,Peluso, M., Overvad, K., et al., Physical activity and lung cancer among non-smokers: A pilot molecular epidemiologic study within EPIC. Biomarker 15:20-30, Emmert SW, Desai D, Richie JP Jr. Enhanced Nrf2-dependent induction of glutathione in mouse embryonic fibroblasts by isoselenocyanate analog of sulforaphane. Bioorg Med Chem Lett (in press) ABSTRACTS OF PRESENTATIONS 1. Richie, J.P., Jr. and Lang, C.A. (1980) The Teton Method: A simple quantitative analysis of life span profiles. Fed. Proc. 39: Richie, J.P., Jr., Mills, B.J., and Lang, C.A. (1981) Increased longevity of adult mosquitoes fed nordihydroguaiaretic acid. Fed. Proc. 40: Richie, J.P., Jr., Mills, B.J., and Lang, C.A. (1981) On the mechanism of nordihydroguaiaretic acid-enhanced longevity. Gerontologist 21: Richie, J.P., Jr. and Lang, C.A. (1982) Acetaminophen toxicity increases with aging in the mosquito. Fed. Proc. 41: Richie, J.P., Jr. and Lang, C.A. (1982) Correlation of acetaminophen toxicity and glutathione levels in senescence. Pharmacologist 24:100 and Toxicologist. 6. Richie, J.P., Jr. and Lang, C.A. (1982) Aging relationships between acetaminophen toxicity and glutathione status. Gerontologist 22: Richie, J.P., Jr., Mills, B.J., and Lang, C.A. (1983) A new bioassay of acute toxicity using the mosquito. Fed. Proc. 42: Richie, J.P., Jr., Mills, B.J., and Lang, C.A. (1983) Magnesium thiazolidine-4-carboxylic acid increases both glutathione levels and longevity. Gerontologist 23: Lang, C.A., Richie, J.P., Jr., and Mills, B.J. (1983) High blood glutathione and top physical health in long-lived women. Gerontologist 23: Richie, J.P., Jr. and Lang, C.A. (1984) Aging differences in acetaminophen metabolism in the mosquito. Fed. Proc. 43: Richie, J.P., Jr., Mills, B.J., and Lang, C.A. (1984) Age-specific biomedical changes in healthy very old women. Gerontologist 24: Mills, B.J., Hollander, J., and Richie, J.P., Jr. (1985) Glutathione stability in stored blood. Fed. Proc. 44:1264.

8 13. Richie, J.P., Jr. and Lang, C.A. (1985) The role of cyst(e)ine in the glutathione deficiency of aging. AGE 8:81. (Selected for oral presentation at the 1st International Congress of Biomedical Gerontology, New York City, July 1985). 14. Richie, J.P., Jr. and Lang, C.A. (1985) On the mechanism for the thiazolidine carboxylic acid induction of glutathione and longevity. Gerontologist 25: Fonda, M.L., Richie, J.P., Jr., Crews, D.E., and Lang, C.A. (1986) Comparison of serum pyridoxal phosphate, age and blood proteins in healthy elderly women. Fed. Proc. 45: Richie, J.P., Jr. and Lang, C.A. (1986) Dietary thiazolidine carboxylates correct the agingspecific cysteine and glutathione deficiencies in the mosquito. Fed. Proc. 45: Richie, J.P., Jr. and Lang, C.A. (1986) The determination of glutathione, cyst(e)ine and other thiols and disulfides in biological samples using HPLC and dual electrochemical detection. Fed. Proc. 45: Mills, B.J., Hollander, J.L., and Richie, J.P., Jr. (1986) Glutathione and cyst(e)ine changes in blood with incubation after cold storage. Fed. Proc. 45: Richie, J.P., Jr. and Lang, C.A. (1986) The maintenance of high glutathione levels in healthy, very old women. Gerontologist 26:80A. 20. Mills, B.J., Lang, C.A., and Richie, J.P., Jr. (1987) Comparison of sample processing methods on glutathione values of human blood. Fed. Proc. 46: Richie, J.P., Jr., Lang, C.A., and Chen, T.S. (1987) Acetaminophen induced depletion of kidney glutathione and cysteine in the mouse. Fed. Proc. 46: Chen, T.S., Richie, J.P., Jr., and Lang, C.A. (1987) The aging decrease in acetaminophen detoxification by glutathione in the mouse. Presented at the Xth International Congress of Pharmacology, Sydney, Australia. 23. Chen, T.S., Richie, J.P., Jr., and Lang, C.A. (1988) A glutathione and cysteine deficiency in the aging mouse kidney leads to impaired acetaminophen detoxification. FASEB J. 2:A Lang, C.A., Richie, J.P., Jr., and Chen, T.S. (1988) Differential glutathione and cyst(e)ine levels in the brain of the aging mouse. FASEB J. 2:A Chen, T.S., Richie, J.P., Jr., and Lang, C.A. (1988) Glutathione ester protects against glutathione deficiencies due to aging and acetaminophen. Pharmacologist 30:A Sepkovic, D.W., Richie, J.P., Jr., Axelrad, C.M., DeNicola, M.A., and Haley, N.J. (1988) Nicotine metabolism in naive and nicotine treated rats. International Conference on Nicotine Receptors in the CNS. Uppsala (Sweden). 27. Richie, J.P., Jr., Aebig, K.W., Axelrad, C.A., Cronin, P.A., and Haley, N.J. (1988) Comparison of total cholesterol values obtained using the Kodak DT-60 portable

9 analyzer and the Kodak Ektachem 400 Clinical Analyzer. The National Cholesterol Conference, Arlington, VA. Abstr. T-9, p Mills, B.J., Richie, J.P., Jr., and Lang, C.A. (1989) The determination of glutathione disulfide in human blood. FASEB J. 3:A Chen, T.S., Richie, J.P., Jr., and Lang, C.A. (1990) Glutathione ester corrects the kidney glutathione and cysteine deficiencies in the aging mouse. The Toxicologist 10: Richie, J.P., Jr., Haley, N.J., Kabat, G.C., Strong, E.W., and Wynder, E.L. (1990) The role of nutritional factors in oral cavity cancer. J. Cancer Res. Clin. Oncol. 116:S Vogt, B.L., Haley, N.J., Mattison, D.R., and Richie, J.P., Jr. (1991) Preparation of antibodies to acetaldehyde-protein adducts formed in vitro. Alcohol Clin. Exp. Res. 15: Hebert, J., Barone, J., Miller, D., Richie, J.P., Jr., and Reddy, MM. (1991) Changes in erythrocyte fatty acids and natural killer cell activity in humans. FASEB J. 5:A Vogt, B.L. and Richie, J.P., Jr. (1992) The role of glutathione in ethanol toxicity during aging. Alcohol Clin. Exp. Res. 16: Leutzinger, Y., Parthasarathy, S., Malloy, V., Zimmerman, J.A., and Richie, J.P., Jr. (1992) High blood glutathione in aging F344 rats fed a methionine-restricted diet. Age 15: Arpadi, S., Muscat, J., Zang, E., and Richie, J.P., Jr. (1993 Glutathione in HIV-infected children with growth failure. IXth Intl. Conf. on AIDS, IVth STD World Congress, Berlin, Abstract PO B , p Vogt, B.L. and Richie, J.P., Jr. (1993) Fasting-induced depletion of glutathione in the aging mouse. Age Hecht, S.S., Carmella, S.G., Akerkar, S., and Richie, J.P., Jr. (1994) 4- (Methylnitrosamino)-1-(3-pyridyl)-1-butanol (NNAL) and its glucuronide, metabolites of a tobacco-specific lung carcinogen, in the urine of black and white smokers. Proc. Am. Assoc. Ca. Res. 35: Lazarus, P., Garewal, H.S., Sciubba, J., Zweibel, N., Muscat, J., and Richie, J.P. Jr. (1994) P53 mutations in preneoplastic lesions of the oral cavity. ASCO, Dallas. 39. Richie, J.P., Jr. Role of glutathione deficiency in the biological aging process. (1994) Therapeutic Potential of Biological Antioxidants Symposium, Tiburon, CA. 40. Hecht, S.S., Carmella, S.G., Murphy, S.E., Idris, A.M., Richie, J.P., Jr., and Hoffmann, D. (1994) Recent studies on tobacco-specific nitrosamines. XVI International Cancer Congress, New Delhi. 41. Hecht, S.S., Staretz, M.E., Trushin, N., Carmella, S.G., Richie, J.P., Jr., Chung, F.-L., Anderson, L.M., and Rice, J.M. (1994) Chemoprevention of lung cancer with isothiocyanates. XVI International Cancer Congress, New Delhi.

10 42. Richie, J.P., Jr., Skowronski, L.A., Leutzinger, Y., Zimmerman, J.A., and Orentreich, N. (1994) The role of glutathione in the enhancement of longevity by methionine restriction in F344 rats. AGE, Washington, D.C. 43. Richie, J.P., Jr., Scott, D., and Muscat, J.E. (1995) Acetylation and CYPIA2 phenotypes in Black and White Smokers. Proc. Am. Assoc. Ca. Res. 36: Richie, J.P., Jr., Komninou, D., Orentreich, N., Zimmerman, J.A., and Leutzinger, Y. (1996) Effects of methionine restriction on tissue glutathione in F-344 rats. FASEB J 45. Komninou, D., Leutzinger, Y., Reddy, B.S., Richie, J.P., Jr. (1996) Effects of aging and methionine restriction on preneoplastic aberrant crypt foci formation in rat colon. Proc. Am. Assoc. Ca. Res. 37: Muscat, J.E., Carmella, S.G., Akerkar, S.A., Scott, D., Hecht, S.S., and Richie, J.P., Jr. (1996) Gender differences in the metabolism of the tobacco-specific nitrosamine 4- (methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK). Proc. Am. Assoc. Ca. Res. 37: Muscat, J.E., Stellman, S.D., Carmella, S.G., Akerkar, S., Fallon, J., Hecht, S.S. and Richie, J.P., Jr. (1997) Body mass, lung cancer histology and metabolism of the tobacco-specific nitrosamine 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK). Proc. Am. Assoc. Ca. Res. 38: Zhao, Z., Khachik, F., Richie, J.P., Jr., and Cohen, L. (1997) Uptake and tissue disposition of dietary lycopene in F344 rats. Proc. Am. Assoc. Ca. Res. 38: Djordjevic, M., Fan, J., Akerkar, S., Fallon, J., Richie, J.P., Jr., and Hoffmann, D. (1997) Does nicotine addiction increase the risk for lung cancer? Proc. Am. Assoc. Ca. Res. 38: Nath, R.G., Ocando, J.E., Richie, J.P., Jr., and Chung, F-L. (1997) Effects of L- buthionine-[s,r]-sulfoximine on 1, N 2 -propanodeoxyguanosine adduct levels in tissue DNA of F344 rats. Proc. Am. Assoc. Ca. Res. 38: Komninou, D., Leutzinger, Y., Reddy, B.S., and Richie, J.P., Jr. (1997) Enhanced colon carcinogenesis in aging rats. AGE, Philadelphia. 52. Komninou, D., Leutzinger, Y., Reddy, B.S., Fiala, E.S., and Richie, J.P., Jr. (1998) Enhanced colon carcinogenesis in aging rats. Proc. Am. Assoc. Ca. Res. 39: Park, J., Ren, Q., Schantz, S.P., Stern, J., Richie, J.P., Jr., Sheikh, S.N., and Lazarus, P. (1998) p53 mutations in oral tumors are associated with specific CYP1A1 and GSTM1 polymorphic genotypes and patient tobacco use. Proc. Am. Assoc. Ca. Res 39: Richie, J.P., Jr., Winters, B., Kleinman, W.A., and Wynder, E.L. (1998) Measurement and stability of total plasma fatty acid levels in human subjects. FASEB J 12:A Kleinman, W.A., Leutzinger, Y., Abraham, P., Skowronski, L., and Richie, J.P., Jr. (1998) Individual variation in free and bound GSH levels in human blood. FASEB J:12:A559.

11 56. Kaur, T., Stellman, S., Travaline, J., Albino, A., Richie, J.P., Jr., Ren, Q., and Lazarus, P. (1999) Role of the O 6 -alkylguanine DNA alkyltransferase codon 160 polymorphysism in lung cancer risk. Proc. Am. Assoc. Ca. Res. 40: Djordjevic, M.V., Thompson, S., Richie, J.P., Jr., and Stellman, S.D. (1999) Smoking behavior affects delivered doses of nicotine and carcinogens. SRNT 58. Richie, J.P., Jr., Komninou D., and Albino, A.P.(2000) Glutathione depletion induces colon carcinogenesis in p53-knockout mice. Proc. Am. Assoc. Ca. Res. 41: Komninou D. and Richie, J.P., Jr. (2000) Oral glutathione inhibits colon carcinogenesis in rats. Proc. Am. Assoc. Ca. Res. 41: Conaway, C.C., Krzeminski, J., Amin, S., Kleinman, W.A., Richie, J.P., Jr., Dong, Z., Wang, C.-X., and Chung, F.L. (2000) N-Acetylcysteine conjugates of isothiocyanates inhibit lung tumors induced by a tobacco carcinogen at post-initiation stages. Proc. Am. Assoc. Ca. Res. 41: Djordjevic, M.V., Stellman, S.D., Anagnostopoulos, H., Richie, J.P., Jr. (2000) Gender differences in levels of urinary biomarkers of exposure to nicotine and carcinogens in cigarette smoke. Tobacco Science Research Conference. 62. Stellman, S.D., Djordjevic, M.V., Muscat J.E., Richie, J.P., Jr. (2001) Gender differences in levels of urinary biomarkers of exposure to nicotine and carcinogens in cigarette smoke. Am. Soc. Prev. Oncol. 63. Muscat J.E., Djordjevic, M.V., Day Stephenson, G., Cox, J., Stellman, S.D., and Richie, J.P., Jr. (2001) Differences in exposure to tobacco smoke constituents in healthy black and white smokers. Proc. Am. Assoc. Ca. Res. 42: El-Bayoumy, K., Richie, J.P., jr., Kleinman, W.A., Komninou, D., and Cox, J. (2001) Selenium-enriched yeast enhances blood glutathione levels in healthy American and Caucasian men in a randomized controlled trial. Proc. Am. Assoc. Ca. Res. 42: Narayanan, N.K., Narayanan, B.A., Komninou, D., Kleinman, W.A., Reinhart, L., Richie, J.P., jr. and Albino, A.P. (2001) Glutathione depletion impacts global gene expression profiles in melanoma and colon cancer cells. Proc. Am. Assoc. Ca. Res. 42: Muscat, J.E., Kleinman, W.A., Colosimo, S., Czander, A., Stellman, S.D. and Richie, J.P., Jr. (2002) Comparison of glutathione (GSH) levels in healthy black and white smokers. Proc. Am. Assoc. Ca. Res. 43: Stephenson, G.D., Chen S., Djordjevic, M., Muscat, J.E., Stellman, S.D. and Richie, J.P., Jr. (2002) Effects of dietary intake of cruciferous vegetables on carcinogen metabolism in smokers. Proc. Am. Assoc. Ca. Res. 43: Komninou, D., Chung, F-L., Zheng, L., Pan, J. and Richie, J.P., Jr. (2002) In vivo glutathione depletion enhances the formation of t-4-hydroxy-2-nonenal-derived DNA adducts in rats. Proc. Am. Assoc. Ca. Res. 43:4260.

12 69. Komninou, D., Spratt, T., Sohn, O-S., Shah, S., Gilhooly, E.M., Fiala, E.S. and Richie, J.P., Jr. (2002) Repair capacity for AOM-induced DNA adducts in rat colon during aging. Proc. Am. Assoc. Ca. Res. 43: Richie, J.P., Jr., Komninou, D., Huang, Z., Kleinman, W.A., Calcagnotto, A., and Schwartz, J.L. (2003) Enhanced protein glutathiolation in oral carcinogenesis. Proc. Am. Assoc. Ca. Res. 44:1254, # Muscat, J.E., Kleinman, W.A., Muir, A., Stellman, S.D., and Richie, J.P., Jr. (2003) Alcohol and smoking effects on blood levels of glutathione (GSH) and proteinglutathiolation. Proc. Am. Assoc. Ca. Res. 44:897, # Zhang, J., Hosey, J., Chen, S., Zang,E., Muscat, J.E., Czander,A., Tika, M., Djordjevic, M., Stellman, S., and Richie, J.P., Jr. (2003) Higher uptake and/or metabolic activation of polycyclic aromatic hydrocarbons from mainstream smoke in menthol versus nonmenthol cigarette smokers. Proc. Am. Assoc. Ca. Res. 44:1282, #R Bendaly, J., Dosset, N., Elahi, A., Mericle, L., Richie, J.P., Jr. (2003) UGT1A9 and UGT2B7 polymorphisms: identification and prevalence in multiple racial groups. Proc. Am. Assoc. Ca. Res. 44:509, #2590.