Ten years CHMG: Highlights. Andreas Engert on behalf of the CHMG

Size: px
Start display at page:

Download "Ten years CHMG: Highlights. Andreas Engert on behalf of the CHMG"

Transcription

1 Ten years CHMG: Highlights Andreas Engert on behalf of the CHMG

2 Ten years CHMG: Highlights Cochrane Collaboration CHMG Highlights Summary

3 Cochrane Collaboration: Background International, independent non-profit organisation First Cochrane Center Oxford 1992 Cochrane Collaboration founded Cochrane Review Groups Generation, publication and dissemination of Cochrane Reviews Impact factor now 6.186!

4 Steering Group Cochrane Collaboration: Organisation Cochrane Centers Fields Consumer Network Cochrane Review Groups Methods Groups

5 Cochrane Review: a structured process Clinical relevant question Title registered with the Collaboration Protocol published Sensitive search strategy Trial identification (in duplicate) Data extraction (in duplicate) Data synthesis (with/without meta-analysis) According to PRISMA

6 Ten years CHMG: Highlights Cochrane Collaboration CHMG Highlights Summary

7 CHMG History 1999: Grant application Competence Network Malignant Lymphoma (KML) 2001: CHMG registered with the Cochrane Collaboration 2011: Comprehensive international and multidisciplinary network of clinicians, scientists and patient representatives

8 CHMG Scope Hodgkin and Non Hodgkin Lymphoma Acute and chronic leukemias Myelodysplastic Syndromes Multiple Myeloma Stem Cell Transplantation Aplastic Anaemia Haematopoietic Growth Factors Supportive Care in Hematology

9 CHMG Contributors 354 authors 15 editors 8 staff at the Editorial Base 1 consumer editor

10 CHMG authors from 30 countries

11 Protocols and Reviews by the CHMG

12 CHMG Co-operation (selection) German Cochrane Center German National Library of Medicine JNCI (Biannual reports) NICE, UK Agency for Healthcare Research and Quality, USA Institute for Quality and Efficiency in Health Care German Hodgkin Study Group German CLL Study Group EORTC

13 Projects Editorial Base (selection) Cochrane Reviews (BMBF) - Network Meta-Analyses (CLL, CML, G-CSF) - IPDs (ESAs, NHL, HL) - Prognostic factor project (CLL) - Cochrane Reviews Consumer Network (German Cancer Aid) Evidence-based S3 Guideline on HL (DKH)

14 CHMG: Selected papers G-CSF and GM-CSF in malignant lymphoma Bohlius et al, Br J Haematol 2003 Recombinant human erythropoietin in cancer patients Bohlius et al, JNCI 2005 Consort statement in reporting clinical trials in Hodgkins lymphoma Kober et al, JNCI 2006 Recombinant human erythropoietins and cancer patients Bohlius et al, JNCI 2006 High-dose chemotherapy in first-line aggressive NHL Greb et al, Cancer Treat Rev 2007 Rituximab and OS in indolent lymphoma Schulz et al, JNCI 2007 IPD on ESAs in cancer patients Bohlius et al, Lancet 2009

15 CHMG Funding Kompetenznetz Maligne Lymphome (KML) German Ministry of Education and Research (BMBF) German Cancer Aid German Research Foundation (DFG) University Hospital Cologne

16 Cochrane Collaboration: Funding

17 Ten years CHMG: Highlights Cochrane Collaboration CHMG Highlights Summary

18 Costs of new drugs in cancer medicine Garattini 2002

19 Anemia: Rationale for SRs on ESAs Anemia frequent among cancer patients Impacts organ function and QoL Negative prognostic factor in several malignancies Erythropoiesis-stimulating agents (ESAs) effective Total annual EPO sales >10 Billion US$ Safety concerns; impact on OS unclear

20 Thrombosis related to ESAs (35 studies) Bohlius et al, JNCI 2005

21 Literature-based SR on ESAs (OS) Period Studies Patients RR 95% CI Bohlius et al, JNCI 2005, 2006

22 IPD on ESAs: Methods Analyses predefined in peer-reviewed, published protocol Analyses performed in two academic centers Steering Committee consisting of clinicians and methodologists Individual patient data contributed by companies (Amgen, J&J, Roche) and independent trialists Funded by German Federal Ministry of Education and Research (BMBF) and OncoSuisse

23 IPD on ESAs: Studies included n Pts All Chemotherapy Radiochemotherapy Radiotherapy None Others Bohlius et al, Lancet 2009

24 IPD on ESAs: Endpoints On study mortality - All cancer patients; chemotherapy only trials Overall survival - All cancer patients; chemotherapy only trials

25 IPD on ESAs: On study mortality* n HR P-value All cancer patients 13, ( ) Chemotherapy trials 10, ( ) 0.12 There was no statistically significant heterogeneity among trials *Deaths during active study phase

26 IPD on ESAs: Summary ESA increased on-study mortality and worsened overall survival in cancer patients For patients undergoing chemotherapy, the increase was less pronounced, but could not be excluded The increased mortality must be balanced against the benefits of ESAs, taking into account each patient s clinical circumstances and preferences Bohlius, ASCO 2009

27 Impact in the Media

28 Ten years CHMG: Highlights Cochrane Collaboration CHMG Highlights Summary

29 Ten years CHMG: Summary CHMG successfully established Generates Systematic Reviews in hematology (>50 reviews&protocols) Published in Cochrane Library and other high-impact journals (Lancet, JNCI) Strategic national & international collaboration Developed HTA reports (NICE, AHRQ, IQWIG) and clinical guidelines (HL, ESAs, G-CSF ) EbM extremely relevant in decision-making

30 Co-ordinating Editor Andreas Engert Editorial Base Kathrin Bauer Ursula Georgi- Mikolajczyk Sabine Kluge Ina Monsef Michaela Rancea Bettina Schmidtke Nicole Skoetz Andrea Will Editoren Julia Bohlius, CH Michael Crump, CDN Benjamin Djulbegovic, USA Ambuj Kumar, USA Jörg J. Meerpohl, D Pia Raanani, IL Sue Richards, UK Guido Schwarzer, D Laurie Sehn, CDN Ofer Shpilberg, IL Lena Specht, DK Sven Trelle, CH Olaf Weingart, D Keith Wheatley, UK Consumer Editor Céline Fournier

31 Special thanks to: Thilo Kober Julia Bohlius Gail Higgins Olaf Weingart Michael Hallek Gerd Antes Editorial Base Team Editors and Reviewers Colleagues & Friends at Med I BMBF, German Cancer Aid, DFG Bettina Schmidtke Nicole Skoetz

COCHRANE HAEMATOLOGICAL MALIGNANCIES GROUP NEWSLETTER

COCHRANE HAEMATOLOGICAL MALIGNANCIES GROUP NEWSLETTER F COCHRANE HAEMATOLOGICAL MALIGNANCIES GROUP NEWSLETTER Issue 4 October 2008 Welcome to our fourth newsletter! Inside this issue First Impact Factor for Cochrane Reviews News from the Editorial Base New

More information

COCHRANE HAEMATOLOGICAL MALIGNANCIES GROUP NEWSLETTER

COCHRANE HAEMATOLOGICAL MALIGNANCIES GROUP NEWSLETTER F COCHRANE HAEMATOLOGICAL MALIGNANCIES GROUP NEWSLETTER Issue 5 October 2009 Welcome to our fifth newsletter! Inside this issue The 2008 Impact Factor for Cochrane Reviews Free trial access News from the

More information

COCHRANE HAEMATOLOGICAL MALIGNANCIES GROUP

COCHRANE HAEMATOLOGICAL MALIGNANCIES GROUP COCHRANE HAEMATOLOGICAL MALIGNANCIES GROUP NEWSLETTER Welcome to our sixth newsletter! Issue 6 October 2010 INSIDE THIS ISSUE First announcement: 10 years CHMG CHMG and its funding sources The 2009 impact

More information

Systematic Reviews in Hematological Malignancies

Systematic Reviews in Hematological Malignancies Systematic Reviews in Hematological Malignancies Pia Raanani, MD Davidoff Cancer Center Rabin Medical Center, Israel 1 2 Disorder CHMG Systematic review* Title Protocol Full Review Myelodysplastic syndrome

More information

New Evidence reports on presentations given at EHA/ICML Bendamustine in the Treatment of Lymphoproliferative Disorders

New Evidence reports on presentations given at EHA/ICML Bendamustine in the Treatment of Lymphoproliferative Disorders New Evidence reports on presentations given at EHA/ICML 2011 Bendamustine in the Treatment of Lymphoproliferative Disorders Report on EHA/ICML 2011 presentations Efficacy and safety of bendamustine plus

More information

Effective Health Care

Effective Health Care Number 3 Effective Health Care Comparative Effectiveness of Epoetin and Darbepoetin for Managing Anemia in Patients Undergoing Cancer Treatment Executive Summary Background Anemia (deficiency of red blood

More information

German Hodgkin Study Group

German Hodgkin Study Group German Hodgkin Study Group Deutsche Hodgkin Studiengruppe Avoiding Relapse of Hodgkin Lymphoma: Have We Moved The Needle? Andreas Engert, MD Chairman, German Hodgkin Study Group University Hospital of

More information

Media Release. Basel, 7 November 2013

Media Release. Basel, 7 November 2013 Media Release Basel, November 2013 Roche s Gazyva helped people with one of the most common forms of blood cancer live significantly longer without their disease worsening compared to MabThera/Rituxan

More information

Donor Lymphocyte Infusion for Malignancies Treated with an Allogeneic Hematopoietic Stem-Cell Transplant

Donor Lymphocyte Infusion for Malignancies Treated with an Allogeneic Hematopoietic Stem-Cell Transplant Last Review Status/Date: September 2014 Page: 1 of 8 Malignancies Treated with an Allogeneic Description Donor lymphocyte infusion (DLI), also called donor leukocyte or buffy-coat infusion is a type of

More information

Blood Cancers. Blood Cells. Blood Cancers: Progress and Promise. Bone Marrow and Blood. Lymph Nodes and Spleen

Blood Cancers. Blood Cells. Blood Cancers: Progress and Promise. Bone Marrow and Blood. Lymph Nodes and Spleen Blood Cancers: Progress and Promise Mike Barnett & Khaled Ramadan Division of Hematology Department of Medicine Providence Health Care & UBC Blood Cancers Significant health problem Arise from normal cells

More information

Lorne A. Becker MD Emeritus Professor SUNY Upstate Medical University. Co-Chair, Cochrane Collaboration Steering Group

Lorne A. Becker MD Emeritus Professor SUNY Upstate Medical University. Co-Chair, Cochrane Collaboration Steering Group Lorne A. Becker MD Emeritus Professor SUNY Upstate Medical University Co-Chair, Cochrane Collaboration Steering Group Many different types Vary in Complexity Trustworthiness of conclusions http://www.ahrq.gov/clinic/uspstf/uspscopd.htm

More information

Epoetin and Darbepoetin for Managing Anemia in Patients Undergoing Cancer Treatment: Comparative Effectiveness Update

Epoetin and Darbepoetin for Managing Anemia in Patients Undergoing Cancer Treatment: Comparative Effectiveness Update Comparative Effectiveness Review Number 113 Epoetin and Darbepoetin for Managing Anemia in Patients Undergoing Cancer Treatment: Comparative Effectiveness Update Comparative Effectiveness Review Number

More information

Media Release. Basel, 10 December 2017

Media Release. Basel, 10 December 2017 Media Release Basel, 10 December 2017 Phase II data showed Roche s investigational polatuzumab vedotin plus bendamustine and MabThera/Rituxan (BR) increased complete response rates compared to BR alone

More information

CONSIDERATIONS IN DESIGNING ACUTE GVHD PREVENTION TRIALS: Patient Selection, Concomitant Treatments, Selecting and Assessing Endpoints

CONSIDERATIONS IN DESIGNING ACUTE GVHD PREVENTION TRIALS: Patient Selection, Concomitant Treatments, Selecting and Assessing Endpoints CONSIDERATIONS IN DESIGNING ACUTE GVHD PREVENTION TRIALS: Patient Selection, Concomitant Treatments, Selecting and Assessing Endpoints CENTER FOR INTERNATIONAL BLOOD AND MARROW TRANSPLANT RESEARCH Potential

More information

Funding of patient-oriented clinical research by the German Federal Ministry of Education and Research (BMBF)

Funding of patient-oriented clinical research by the German Federal Ministry of Education and Research (BMBF) Funding of patient-oriented clinical research by the German Federal Ministry of Education and Research (BMBF) Dr. Steinmüller/ Dr. Jacobs July 8th, 2011, Cologne Overview Health research programme of the

More information

June 12, Dear Dr. Phurrough:

June 12, Dear Dr. Phurrough: June 12, 2007 Steve E. Phurrough, MD, MPA Director, Coverage and Analysis Group Centers for Medicare & Medicaid Services Mail Stop C1-09-06 7500 Security Boulevard Baltimore, MD 21244 Dear Dr. Phurrough:

More information

Anaemia & Cancer. John de Vos Consultant Haematologist RSCH

Anaemia & Cancer. John de Vos Consultant Haematologist RSCH Anaemia & Cancer John de Vos Consultant Haematologist RSCH overview Definitions & setting the scene Causes Consequences Biology Treatment Personal approach Patient Clinical team Anaemia - Definition :

More information

Comparing outcome between Belgian haematopoietic stem cell transplant centres

Comparing outcome between Belgian haematopoietic stem cell transplant centres ENCR2016, 2014/06/10 1 Comparing outcome between Belgian haematopoietic stem cell transplant centres Gilles Macq 1, Evelien Vaes 1, Geert Silversmit 1, Marijke Vanspauwen 1, Liesbet Van Eycken 1 & Yves

More information

Chemotherapy alone versus chemotherapy plus radiotherapy for early stage Hodgkin lymphoma (Review)

Chemotherapy alone versus chemotherapy plus radiotherapy for early stage Hodgkin lymphoma (Review) Chemotherapy alone versus chemotherapy plus radiotherapy for early stage Hodgkin lymphoma (Review) Herbst C, Rehan FA, Skoetz N, Bohlius J, Brillant C, Schulz H, Monsef I, Specht L, Engert A This is a

More information

Are the ESMO guidelines adapted to the elderly? D. Schrijvers, MD, PhD Ziekenhuisnetwerk Antwerpen(ZNA)-Middelheim Antwerp Belgium

Are the ESMO guidelines adapted to the elderly? D. Schrijvers, MD, PhD Ziekenhuisnetwerk Antwerpen(ZNA)-Middelheim Antwerp Belgium Are the ESMO guidelines adapted to the elderly? D. Schrijvers, MD, PhD Ziekenhuisnetwerk Antwerpen(ZNA)-Middelheim Antwerp Belgium Clinical practice guidelines Definition > Systemically developed statements

More information

April 12, Coverage of ESAs for Patients with Conditions Other than End-Stage Renal Disease

April 12, Coverage of ESAs for Patients with Conditions Other than End-Stage Renal Disease [ASH Comments to the Centers for Medicare and Medicaid Services on coverage for Erythropoiesis Stimulating Agents (ESAs) filed electronically on April 12, 2007] April 12, 2007 The American Society of Hematology

More information

Literature Scan: Erythropoiesis Stimulating Agents

Literature Scan: Erythropoiesis Stimulating Agents Copyright 2012 Oregon State University. All Rights Reserved Drug Use Research & Management Program Oregon State University, 500 Summer Street NE, E35 Salem, Oregon 97301-1079 Phone 503-947-5220 Fax 503-947-1119

More information

Dissemination experiences from CONSORT and other reporting guidelines

Dissemination experiences from CONSORT and other reporting guidelines Dissemination experiences from CONSORT and other reporting guidelines Doug Altman Centre for Statistics in Medicine, Oxford EQUATOR Network [Altman and Goodman, JAMA 1994] 2 Passive

More information

Problems related to the management of malignant hemopathies in older patients

Problems related to the management of malignant hemopathies in older patients Problems related to the management of malignant hemopathies in older patients Dr Marie Maerevoet Gent, 25 January 2013 BHS satellite symposium on Elderly Malignant Hemopathies in older patients - 33% of

More information

EBMT Society EBMT. History Organisation Studies Activity Philosophy. EBMT Website. European Group for Blood and Marrow Transplantation

EBMT Society EBMT. History Organisation Studies Activity Philosophy. EBMT Website. European Group for Blood and Marrow Transplantation EBMT EBMT Organisation and Activities J Apperley 13th. ESH-EBMT Training Course Targu Mures May 24 26, 2010 History Organisation Studies Activity Philosophy EBMT Website www.ebmt.org EBMT Society European

More information

Erythropoiesis stimulationg agents: evidence for their use for the treatment of anemia in

Erythropoiesis stimulationg agents: evidence for their use for the treatment of anemia in Erythropoiesis stimulationg agents: evidence for their use for the treatment of anemia in thoracic tumors and MICU Dr Dipesh Maskey Senior Resident Dept of Pulmonary & CCM 14 th Oct 2011 Anemia and cancer

More information

Erythropoietin or Darbepoetin for patients with cancer - meta-analysis based on individual patient data (Review)

Erythropoietin or Darbepoetin for patients with cancer - meta-analysis based on individual patient data (Review) Erythropoietin or Darbepoetin for patients with cancer - meta-analysis based on individual patient data (Review) Bohlius J, Schmidlin K, Brillant C, Schwarzer G, Trelle S, Seidenfeld J, Zwahlen M, Clarke

More information

Induction Chemo-Immunotherapy with the Matrix Regimen in Patients with Newly Di... Advertisement

Induction Chemo-Immunotherapy with the Matrix Regimen in Patients with Newly Di... Advertisement Page 1 of 5 Induction Chemo-Immunotherapy with the Matrix Regimen in Patients with Newly Diagnosed PCNSL - a Multicenter Retrospective Analysis on Feasibility and Effectiveness in Routine Clinical Practice

More information

Update: Non-Hodgkin s Lymphoma

Update: Non-Hodgkin s Lymphoma 2008 Update: Non-Hodgkin s Lymphoma ICML 2008: Update on non-hodgkin s lymphoma Diffuse Large B-cell Lymphoma Improved outcome of elderly patients with poor-prognosis diffuse large B-cell lymphoma (DLBCL)

More information

Media Release. CHMP recommends EU approval of Roche s Gazyvaro for people with previously untreated advanced follicular lymphoma. Basel, 21 July 2017

Media Release. CHMP recommends EU approval of Roche s Gazyvaro for people with previously untreated advanced follicular lymphoma. Basel, 21 July 2017 Media Release Basel, 21 July 2017 CHMP recommends EU approval of Roche s Gazyvaro for people with previously untreated advanced follicular lymphoma Pivotal GALLIUM study demonstrated that Gazyvaro-based

More information

Principal Investigator. General Information. Certification. Research Proposal. Project Title

Principal Investigator. General Information. Certification. Research Proposal. Project Title Principal Investigator First Name: Craig Last Name: French Degree: MD Primary Affiliation: Monash University E-mail: howard.l.corwin@gmail.com Phone number: 603 252-6829 Address: Department of Intensive

More information

July 3, The Physician Compare Team Centers for Medicare and Medicaid Services 7500 Security Boulevard Baltimore, MD 21244

July 3, The Physician Compare Team Centers for Medicare and Medicaid Services 7500 Security Boulevard Baltimore, MD 21244 July 3, 2013 The Physician Compare Team Centers for Medicare and Medicaid Services 7500 Security Boulevard Baltimore, MD 21244 Re: Physician Compare Intelligent Search To Whom it May Concern, The American

More information

Leukine. Leukine (sargramostim) Description

Leukine. Leukine (sargramostim) Description Federal Employee Program 1310 G Street, N.W. Washington, D.C. 20005 202.942.1000 Fax 202.942.1125 Subject: Leukine Page: 1 of 6 Last Review Date: November 30, 2018 Leukine Description Leukine (sargramostim)

More information

Roche to present new clinical data across a variety of blood diseases at American Society of Hematology 2015 Annual Meeting

Roche to present new clinical data across a variety of blood diseases at American Society of Hematology 2015 Annual Meeting Media Release Basel, 5 November 2015 Roche to present new clinical data across a variety of blood diseases at American Society of Hematology 2015 Annual Meeting Gazyva/Gazyvaro (obinutuzumab) and investigational

More information

Venous Thromboembolic Events and Erythropoiesis-Stimulating Agents: An Update

Venous Thromboembolic Events and Erythropoiesis-Stimulating Agents: An Update Venous Thromboembolic Events and Erythropoiesis-Stimulating Agents: An Update Mario Dicato Hematology-Oncology Service, Luxembourg Medical Centre, Luxembourg Key Words. Erythropoiesis-stimulating agents

More information

Media Release. Roche receives EU approval of Gazyvaro for people with previously untreated advanced follicular lymphoma. Basel, 22 September 2017

Media Release. Roche receives EU approval of Gazyvaro for people with previously untreated advanced follicular lymphoma. Basel, 22 September 2017 Media Release Basel, 22 September 2017 Roche receives EU approval of Gazyvaro for people with previously untreated advanced follicular lymphoma Approval is based on phase III GALLIUM study results, which

More information

Lymphocyte Predominant Hodgkin s Lymphoma. Case Presentation. How would you treat the patient?

Lymphocyte Predominant Hodgkin s Lymphoma. Case Presentation. How would you treat the patient? Lymphocyte Predominant Hodgkin s Lymphoma Wei Ai, MD, PhD Assistant Clinical Professor University of California, San Francisco January 2010 Case Presentation 32 yo male, diagnosed with stage IIIA lymphocyte

More information

Obinutuzumab in combination with bendamustine for treating rituximab-refractory follicular lymphoma

Obinutuzumab in combination with bendamustine for treating rituximab-refractory follicular lymphoma Obinutuzumab in combination with bendamustine for treating rituximab-refractory follicular lymphoma 1 st Appraisal Committee meeting Background and Clinical Effectiveness Committee A Lead team John Watkins

More information

Epogen / Procrit. Epogen / Procrit (epoetin alfa) Description

Epogen / Procrit. Epogen / Procrit (epoetin alfa) Description Federal Employee Program 1310 G Street, N.W. Washington, D.C. 20005 202.942.1000 Fax 202.942.1125 5.10.06 Section: Prescription Drugs Effective Date: April1, 2014 Subject: Epogen / Procrit Page: 1 of 7

More information

Executive Summary. Positron emission tomography (PET and PET/CT) in malignant lymphoma 1. IQWiG Reports Commission No. D06-01A

Executive Summary. Positron emission tomography (PET and PET/CT) in malignant lymphoma 1. IQWiG Reports Commission No. D06-01A IQWiG Reports Commission No. D06-01A Positron emission tomography (PET and PET/CT) in malignant lymphoma 1 Executive Summary 1 Translation of the executive summary of the final report Positronenemissionstomographie

More information

Bendamustine for relapsed follicular lymphoma refractory to rituximab

Bendamustine for relapsed follicular lymphoma refractory to rituximab LONDON CANCER NEW DRUGS GROUP RAPID REVIEW Bendamustine for relapsed follicular lymphoma refractory to rituximab Bendamustine for relapsed follicular lymphoma refractory to rituximab Contents Summary 1

More information

12 th Annual Hematology & Breast Cancer Update Update in Lymphoma

12 th Annual Hematology & Breast Cancer Update Update in Lymphoma 12 th Annual Hematology & Breast Cancer Update Update in Lymphoma Craig Okada, MD, PhD Assistant Professor, Hematology January 14, 2010 Governors Hotel, Portland Oregon Initial Treatment of Indolent Lymphoma

More information

Medication Prior Authorization Form

Medication Prior Authorization Form Procrit, Aranesp and (Epoetin Alfa) Policy Number: 1043 Policy History Approve Date: 12/11/2015 Effective Date: 12/11/2015 Preauthorization All Plans Benefit plans vary in coverage and some plans may not

More information

CARE at ASH 2014 Lymphoma. Dr. Diego Villa Medical Oncologist British Columbia Cancer Agency Vancouver Cancer Centre

CARE at ASH 2014 Lymphoma. Dr. Diego Villa Medical Oncologist British Columbia Cancer Agency Vancouver Cancer Centre CARE at ASH 2014 Lymphoma Dr. Diego Villa Medical Oncologist British Columbia Cancer Agency Vancouver Cancer Centre High-yield lymphoma sessions Sat, Dec 6 th Sun, Dec 7 th Mon, Dec 8 th EDUCATIONAL SESSIONS

More information

Clinical Policy Title: Erythropoietin for end-stage renal disease

Clinical Policy Title: Erythropoietin for end-stage renal disease Clinical Policy Title: Erythropoietin for end-stage renal disease Clinical Policy Number: 00.02.07 Effective Date: June 1, 2015 Initial Review Date: February 19, 2014 Most Recent Review Date: January 11,

More information

Richter s Syndrome: Risk, Predictors and Treatment

Richter s Syndrome: Risk, Predictors and Treatment Richter s Syndrome: Risk, Predictors and Treatment 10/23/2015 John N. Allan MD Assistant Professor of Medicine Division of Hematology and Medical Oncology CLL Research Center Weill Cornell Medicine Agenda

More information

Roche s GAZYVARO approved in Switzerland for people with previously untreated follicular lymphoma which are in need of systemic treatment

Roche s GAZYVARO approved in Switzerland for people with previously untreated follicular lymphoma which are in need of systemic treatment Media Release Basel, 25 July 2017 Roche s GAZYVARO approved in Switzerland for people with previously untreated follicular lymphoma which are in need of systemic treatment Approval is based on phase III

More information

a resource for physicians Recommended Referral Timing for Stem Cell Transplant Evaluation

a resource for physicians Recommended Referral Timing for Stem Cell Transplant Evaluation a resource for physicians Recommended Referral Timing for Stem Cell Transplant Evaluation This resource has been developed to help guide you regarding the appropriate timing and conditions for a referral

More information

The QUOROM Statement: revised recommendations for improving the quality of reports of systematic reviews

The QUOROM Statement: revised recommendations for improving the quality of reports of systematic reviews The QUOROM Statement: revised recommendations for improving the quality of reports of systematic reviews David Moher 1, Alessandro Liberati 2, Douglas G Altman 3, Jennifer Tetzlaff 1 for the QUOROM Group

More information

Surviving Leukemia And Hodgkin's Lymphoma: An Overview Of Effective Treatment Methods By Melinda Baxter READ ONLINE

Surviving Leukemia And Hodgkin's Lymphoma: An Overview Of Effective Treatment Methods By Melinda Baxter READ ONLINE Surviving Leukemia And Hodgkin's Lymphoma: An Overview Of Effective Treatment Methods By Melinda Baxter READ ONLINE If you are searched for a ebook Surviving Leukemia and Hodgkin's Lymphoma: An Overview

More information

Meta-analyses: analyses:

Meta-analyses: analyses: Meta-analyses: analyses: how do they help, and when can they not? Lee Hooper Senior Lecturer in research synthesis & nutrition l.hooper@uea.ac.uk 01603 591268 Aims Systematic Reviews Discuss the scientific

More information

Top Regimens by Diagnostic Group. April July 2012

Top Regimens by Diagnostic Group. April July 2012 Top Regimens by Diagnostic Group April July 2012 Introduction The Top Regimens by Diagnostic Group report provides an overview of the most frequently administered regimens for major tumour sites. Within

More information

Roche presents new data from GALLIUM study reinforcing clinical benefit of Gazyva/Gazyvaro in people with previously untreated follicular lymphoma

Roche presents new data from GALLIUM study reinforcing clinical benefit of Gazyva/Gazyvaro in people with previously untreated follicular lymphoma Media Release Basel, 23 June 2017 Roche presents new data from GALLIUM study reinforcing clinical benefit of Gazyva/Gazyvaro in people with previously untreated follicular lymphoma Longer follow-up showed

More information

Meta-analysis: Methodology

Meta-analysis: Methodology Meta-analysis: Methodology Example: Assessment of cardiovascular safety profile of new generation BCR-ABL TKIs in patients with CML Haguet Hélène 04/03/2016 Meta-analysis = statistical combination of results

More information

BR for previously untreated or relapsed CLL

BR for previously untreated or relapsed CLL 1 Protocol synopsis Title Rationale Study Objectives Multicentre phase II trial of bendamustine in combination with rituximab for patients with previously untreated or relapsed chronic lymphocytic leukemia

More information

CHMP recommends EU approval of Roche s Gazyvaro for people with previously treated follicular lymphoma

CHMP recommends EU approval of Roche s Gazyvaro for people with previously treated follicular lymphoma Media Release Basel, 29 April 2016 CHMP recommends EU approval of Roche s Gazyvaro for people with previously treated follicular lymphoma In the pivotal study, treatment with Gazyvaro plus bendamustine

More information

National Institute for Clinical Excellence. Cancer Treatment Induced Anaemia: Epoetin (alfa and beta) and Darbepoetin alfa.

National Institute for Clinical Excellence. Cancer Treatment Induced Anaemia: Epoetin (alfa and beta) and Darbepoetin alfa. National Institute for Clinical Excellence Cancer Treatment Induced Anaemia: Epoetin (alfa and beta) and Darbepoetin alfa Submission from: Breakthrough Breast Cancer CancerBACUP Leukaemia CARE 8 th November

More information

Leukine. Leukine (sargramostim) Description

Leukine. Leukine (sargramostim) Description Federal Employee Program 1310 G Street, N.W. Washington, D.C. 20005 202.942.1000 Fax 202.942.1125 5.85.08 Subject: Leukine Page: 1 of 5 Last Review Date: September 15, 2017 Leukine Description Leukine

More information

Bendamustine is Effective Therapy in Patients with Rituximab-Refractory, Indolent B-Cell Non-Hodgkin Lymphoma

Bendamustine is Effective Therapy in Patients with Rituximab-Refractory, Indolent B-Cell Non-Hodgkin Lymphoma Bendamustine is Effective Therapy in Patients with Rituximab-Refractory, Indolent B-Cell Non-Hodgkin Lymphoma Kahl BS et al. Cancer 2010;116(1):106-14. Introduction > Bendamustine is a novel alkylating

More information

Idelalisib treatment is associated with improved cytopenias in patients with relapsed/refractory inhl and CLL

Idelalisib treatment is associated with improved cytopenias in patients with relapsed/refractory inhl and CLL Idelalisib treatment is associated with improved cytopenias in patients with relapsed/refractory inhl and CLL Susan M O Brien, Andrew J Davies, Ian W Flinn, Ajay K Gopal, Thomas J Kipps, Gilles A Salles,

More information

Recombinant human erythropoiesis-stimulating agents and mortality in patients with cancer: a meta-analysis of randomised trials

Recombinant human erythropoiesis-stimulating agents and mortality in patients with cancer: a meta-analysis of randomised trials Recombinant human erythropoiesis-stimulating agents and mortality in patients with cancer: a meta-analysis of randomised trials Julia Bohlius, Kurt Schmidlin, Corinne Brillant, Guido Schwarzer, Sven Trelle,

More information

BL-8040: BEST-IN-CLASS CXCR4 ANTAGONIST FOR TREATMENT OF ONCOLOGICAL MALIGNANCIES. Overview and Mechanism of Action Dr.

BL-8040: BEST-IN-CLASS CXCR4 ANTAGONIST FOR TREATMENT OF ONCOLOGICAL MALIGNANCIES. Overview and Mechanism of Action Dr. BL-8040: BEST-IN-CLASS CXCR4 ANTAGONIST FOR TREATMENT OF ONCOLOGICAL MALIGNANCIES Overview and Mechanism of Action Dr. Leah Klapper, CSO 88 BL-8040: Novel CXCR4 Antagonist For Hematological Cancers Indications:

More information

Hematology Measure #2: Myelodysplastic Syndrome (MDS): Documentation of Iron Stores in Patients Receiving Erythropoietin Therapy

Hematology Measure #2: Myelodysplastic Syndrome (MDS): Documentation of Iron Stores in Patients Receiving Erythropoietin Therapy Hematology Measure #2: Myelodysplastic Syndrome (MDS): Documentation of Iron Stores in Patients Receiving Erythropoietin Therapy This measure may be used as an Accountability measure Clinical Performance

More information

ANCO: ASCO Highlights 2018 Hematologic Malignancies

ANCO: ASCO Highlights 2018 Hematologic Malignancies ANCO: ASCO Highlights 2018 Hematologic Malignancies Brian A. Jonas, M.D., Ph.D. UC Davis Comprehensive Cancer Center August 25, 2018 Brian Jonas, MD, PhD ANCO: ASCO Highlights 2018 Relevant financial relationships

More information

Building the Evidence for Global Public Health

Building the Evidence for Global Public Health School of Population Health University of Melbourne Building the Evidence for Global Public Health Exploratory Meeting of the Proposed Cochrane Public Health Collaborative Review Group Monday 29th October

More information

Investor Update. Downloads. Services PDF. Basel, 23 June 2017

Investor Update. Downloads. Services PDF. Basel, 23 June 2017 Investor Update Basel, 23 June 2017 FDA approves Rituxan Hycela (rituximab and hyaluronidase human) for subcutaneous injection in certain blood cancers Treatment can be administered in five to seven minutes,

More information

Mantle cell lymphoma An update on management

Mantle cell lymphoma An update on management Mantle cell lymphoma An update on management Dr Kim Linton Consultant Medical Oncologist The Christie NHS Foundation Trust 6 th October 2016 This educational meeting is organised and sponsored by Janssen-Cilag

More information

Annual Conference of the Canadian Blood and Marrow Transplant Group. June 11 to 14, 2014 The Westin Nova Scotian 1181 Hollis Street Halifax, NS

Annual Conference of the Canadian Blood and Marrow Transplant Group. June 11 to 14, 2014 The Westin Nova Scotian 1181 Hollis Street Halifax, NS Annual Conference of the Canadian Blood Preliminary Program In conjunction with the Canadian National, Canadian Apheresis Group, Society, and Vector CBMTG Head Office Malachite Management Inc 375 West

More information

BL-8040: A Novel CXCR4 Antagonist

BL-8040: A Novel CXCR4 Antagonist BL-8040: A Novel CXCR4 Antagonist December 2012 Forward Looking Statements This presentation contains "forward-looking statements." These statements include words like "may," "expects," "believes," plans,

More information

The case against maintenance rituximab in Follicular lymphoma. Jonathan W. Friedberg M.D., M.M.Sc.

The case against maintenance rituximab in Follicular lymphoma. Jonathan W. Friedberg M.D., M.M.Sc. The case against maintenance rituximab in Follicular lymphoma Jonathan W. Friedberg M.D., M.M.Sc. Follicular lymphoma: What are goals of treatment? Change natural history of disease: Decrease transformation

More information

HMO: Medical (provider setting); Rx (out patient) PPO/CDHP: Rx

HMO: Medical (provider setting); Rx (out patient) PPO/CDHP: Rx BENEFIT DESCRIPTION AND LIMITATIONS OF COVERAGE ITEM: PRODUCT LINES: COVERED UNDER: DESCRIPTION: CPT/HCPCS Code: Company Supplying: Setting: Epogen, Procrit (epoetin alfa, injection) Commercial HMO/PPO/CDHP

More information

MDS - Diagnosis and Treatments. Dr Helen Enright, Adelaide and Meath Hospital Dr Catherine Flynn, St James Hospital

MDS - Diagnosis and Treatments. Dr Helen Enright, Adelaide and Meath Hospital Dr Catherine Flynn, St James Hospital MDS - Diagnosis and Treatments Dr Helen Enright, Adelaide and Meath Hospital Dr Catherine Flynn, St James Hospital Overview What is myelodysplasia? Symptoms Diagnosis and prognosis Myelodysplasia therapy

More information

Technology appraisal guidance Published: 26 November 2014 nice.org.uk/guidance/ta323

Technology appraisal guidance Published: 26 November 2014 nice.org.uk/guidance/ta323 Erythropoiesis-stimulating agents (epoetin and darbepoetin) for treating anaemia in people with cancer having chemotherapy Technology appraisal guidance Published: 26 November 2014 nice.org.uk/guidance/ta323

More information

The UK Cochrane Centre. Trusted evidence. Informed decisions. Better Health.

The UK Cochrane Centre. Trusted evidence. Informed decisions. Better Health. The UK Cochrane Centre Trusted evidence. Informed decisions. Better Health. Who are we and what do we do? Click to edit Master subtitle style Who are we and what do we do? The original Cochrane Centre

More information

Strategies for the Treatment of Elderly DLBCL Patients, New Combination Therapy in NHL, and Maintenance Rituximab Therapy in FL

Strategies for the Treatment of Elderly DLBCL Patients, New Combination Therapy in NHL, and Maintenance Rituximab Therapy in FL New Evidence reports on presentations given at ASH 2009 Strategies for the Treatment of Elderly DLBCL Patients, New Combination Therapy in NHL, and Maintenance Rituximab Therapy in FL From ASH 2009: Non-Hodgkin

More information

Hodgkin Lymphoma Status of the art of treatment

Hodgkin Lymphoma Status of the art of treatment 11.05.2016 1 Hodgkin Lymphoma Status of the art of treatment Peter Borchmann German Hodgkin Study Group University of Cologne, Germany Question No 1: Which statement regarding 1 st line treatment of early

More information

Strategic Plan - Jan Dec 16 (southasia.cochrane.org)

Strategic Plan - Jan Dec 16 (southasia.cochrane.org) Strategic Plan - Jan 2015- Dec 16 (southasia.cochrane.org) Our Network Centre s C o c h r a n e S o u t h A s i a C a r m a n B l o c k, 2 n d F l o o r, C h r i s t i a n M e d i c a l C o l l e g e,

More information

YEREVAN STATE MEDICAL UNIVERSITY DEPARTMENT OF HEMATOLOGY COURSE DESCRIPTION HEMATOLOGY

YEREVAN STATE MEDICAL UNIVERSITY DEPARTMENT OF HEMATOLOGY COURSE DESCRIPTION HEMATOLOGY 1. Module/unit Code II. 1.2. 2. Module/unit Title Hematology 3. Subject Field Internal Diseases Group 4. Faculty/Department General Medicine, Department of Hematology 5. Programme(s) to which the Doctor

More information

Checkpoint Blockade in Hematology and Stem Cell Transplantation

Checkpoint Blockade in Hematology and Stem Cell Transplantation Checkpoint Blockade in Hematology and Stem Cell Transplantation Saad S. Kenderian, MD Assistant Professor of Medicine and Oncology Mayo Clinic College of Medicine October 14, 2016 2015 MFMER slide-1 Disclosures

More information

Study No.: Title: Rationale: Phase: Study Period: Study Design: Centres: Indication: Treatment: Objectives: Primary Outcome/Efficacy Variable:

Study No.: Title: Rationale: Phase: Study Period: Study Design: Centres: Indication: Treatment: Objectives: Primary Outcome/Efficacy Variable: The study listed may include approved and non-approved uses, formulations or treatment regimens. The results reported in any single study may not reflect the overall results obtained on studies of a product.

More information

Maintenance rituximab following response to first-line therapy in mantle cell lymphoma

Maintenance rituximab following response to first-line therapy in mantle cell lymphoma LONDON CANCER NEW DRUGS GROUP RAPID REVIEW Maintenance rituximab following response to first-line therapy in mantle cell lymphoma Maintenance rituximab following response to first-line therapy in mantle

More information

Reporting of Randomized Controlled Trials in Hodgkin Lymphoma in Biomedical Journals

Reporting of Randomized Controlled Trials in Hodgkin Lymphoma in Biomedical Journals Reporting of Randomized Controlled Trials in Hodgkin Lymphoma in Biomedical Journals Thilo Kober, Sven Trelle, Andreas Engert Background : Randomized controlled trials (RCTs) are the best tool to evaluate

More information

Media Release. Basel, 5 December 2016

Media Release. Basel, 5 December 2016 Media Release Basel, 5 December 2016 Roche s Gazyva/Gazyvaro Helped People With Previously Untreated Follicular Lymphoma Live Significantly Longer Without Their Disease Worsening Compared to MabThera/Rituxan

More information

Myelodyplastic Syndromes Paul J. Shami, M.D.

Myelodyplastic Syndromes Paul J. Shami, M.D. Myelodyplastic Syndromes Paul J. Shami, M.D. Professor of Hematology, University of Utah Member, Huntsman Cancer Institute Objectives Define Myelodysplastic Syndromes (MDS) Explain how MDS are diagnosed

More information

Peer Review Report. [erythropoietin-stimulating agents]

Peer Review Report. [erythropoietin-stimulating agents] 21 st Expert Committee on Selection and Use of Essential Medicines Peer Review Report [erythropoietin-stimulating agents] (1) Does the application adequately address the issue of the public health need

More information

CLINICAL REGISTRIES Use and Emerging Best Practices

CLINICAL REGISTRIES Use and Emerging Best Practices CLINICAL REGISTRIES Use and Emerging Best Practices Tim Friede Department of Medical Statistics University Medical Center Göttingen DZHK (German Center for Cardiovascular Research) OUTLINE Background:

More information

AHSCT in Hodgkin lymphoma - indication and challenges. Bastian von Tresckow German Hodgkin Study Group Cologne University Hospital

AHSCT in Hodgkin lymphoma - indication and challenges. Bastian von Tresckow German Hodgkin Study Group Cologne University Hospital AHSCT in Hodgkin lymphoma - indication and challenges Bastian von Tresckow German Hodgkin Study Group Cologne University Hospital AHSCT in Hodgkin Lymphoma The role of AHSCT in HL Mobilisation failure

More information

Jemal A, Siegel R, Ward E, et al: Cancer statistics, CA: Cancer J Clin 59(4):225-49, 2009

Jemal A, Siegel R, Ward E, et al: Cancer statistics, CA: Cancer J Clin 59(4):225-49, 2009 Ovarian cancer 2010-22,500 cases diagnosed per year in the United States and 16,500 deaths per year1. - Most patients are diagnosed in late stages; no screening test exists. - Pathology: 4 different types

More information

Clinical Commissioning Policy Proposition: Bendamustine with rituximab for relapsed indolent non-hodgkin s lymphoma (all ages)

Clinical Commissioning Policy Proposition: Bendamustine with rituximab for relapsed indolent non-hodgkin s lymphoma (all ages) Clinical Commissioning Policy Proposition: Bendamustine with rituximab for relapsed indolent non-hodgkin s lymphoma (all ages) Reference: NHS England 1607 1 First published: TBC Prepared by NHS England

More information

Hematologic Malignancies 2013 Retrospective Study at Truman Medical Center

Hematologic Malignancies 2013 Retrospective Study at Truman Medical Center Hematologic Malignancies 2013 Retrospective Study at Truman Medical Center Kristen Strasser, MD & Abdulraheem Qasem, MD Introduction: Hematologic Malignancies includes malignant diseases of the bone marrow

More information

Revlimid. Revlimid (lenalidomide) Description. Section: Prescription Drugs Effective Date: July 1, 2015

Revlimid. Revlimid (lenalidomide) Description. Section: Prescription Drugs Effective Date: July 1, 2015 Federal Employee Program 1310 G Street, N.W. Washington, D.C. 20005 202.942.1000 Fax 202.942.1125 5.04.47 Subject: Revlimid Page: 1 of 6 Last Review Date: June 19, 2015 Revlimid Description Revlimid (lenalidomide)

More information

London Cancer New Drugs Group APC/DTC Briefing

London Cancer New Drugs Group APC/DTC Briefing London Cancer New Drugs Group APC/DTC Briefing Rituximab for Mantle Cell Lymphoma g Contents Summary Summary & Background 1-2 Introduction 3 Discussion points/issues for Consideration 9 References 12 Background

More information

Treatment of low risk MDS

Treatment of low risk MDS Treatment of low risk MDS Matteo G Della Porta Cancer Center IRCCS Humanitas Research Hospital & Humanitas University Rozzano Milano, Italy matteo.della_porta@hunimed.eu International Prognostic Scoring

More information

Annual Report Division of Hematology Department of Medicine, Jewish General Hospital April 1, December 31, 2011

Annual Report Division of Hematology Department of Medicine, Jewish General Hospital April 1, December 31, 2011 Annual Report Division of Hematology Department of Medicine, Jewish General Hospital April 1, 2011 - December 31, 2011 I HIGHLIGHTS A) Segal Cancer Center After more than five years of operation in the

More information

TREATMENT CONSIDERATIONS IN CLL/SLL AND FL. June 6, 2018

TREATMENT CONSIDERATIONS IN CLL/SLL AND FL. June 6, 2018 TREATMENT CONSIDERATIONS IN CLL/SLL AND FL June 6, 2018 0 PRESENTATION OVERVIEW IN CLL/SLL AND FL: Discuss key considerations that influence patient outcomes Highlight the importance of patients quality

More information

What s a Transplant? What s not?

What s a Transplant? What s not? What s a Transplant? What s not? How to report the difference? Daniel Weisdorf MD University of Minnesota Anti-cancer effects of BMT or PBSCT [HSCT] Kill the cancer Save the patient Restore immunocompetence

More information

Radiotherapy in aggressive lymphomas. Umberto Ricardi

Radiotherapy in aggressive lymphomas. Umberto Ricardi Radiotherapy in aggressive lymphomas Umberto Ricardi Is there (still) a role for Radiation Therapy in DLCL? NHL: A Heterogeneous Disease ALCL PMLBCL (2%) Burkitt s MCL (6%) Other DLBCL (31%) - 75% of aggressive

More information

Clinical Policy Title: Erythropoietin for end-stage renal disease

Clinical Policy Title: Erythropoietin for end-stage renal disease Clinical Policy Title: Erythropoietin for end-stage renal disease Clinical Policy Number: 00.02.07 Effective Date: June 1, 2015 Initial Review Date: February 19, 2014 Most Recent Review Date: January 18,

More information

INFLUENCE OF LOW PROTEIN DIET IN IMPROVING ANEMIA TREATED WITH ERYTHROPOETIN

INFLUENCE OF LOW PROTEIN DIET IN IMPROVING ANEMIA TREATED WITH ERYTHROPOETIN INFLUENCE OF LOW PROTEIN DIET IN IMPROVING ANEMIA TREATED WITH ERYTHROPOETIN, Idrizi A, Barbullushi M, Gjyzari A, Duraku A Department of Nephrology, University Hospital Center, Tirana, Albania Introduction

More information

ABVD or BEACOPP for advanced Hodgkin lymphoma. Not to BEACOPP. Massimo Federico University of Modena and Reggio Emilia Italy

ABVD or BEACOPP for advanced Hodgkin lymphoma. Not to BEACOPP. Massimo Federico University of Modena and Reggio Emilia Italy ABVD or BEACOPP for advanced Hodgkin lymphoma Not to BEACOPP Massimo Federico University of Modena and Reggio Emilia Italy What is the best Induction Therapy for Advanced Hodgkin Lymphoma? How to treat

More information