Detection and Clinical Significance of Lymph Node Micrometastasis in Gastric Cardia Adenocarcinoma

Save this PDF as:
 WORD  PNG  TXT  JPG

Size: px
Start display at page:

Download "Detection and Clinical Significance of Lymph Node Micrometastasis in Gastric Cardia Adenocarcinoma"

Transcription

1 The Journal of International Medical Research 2012; 40: [first published online ahead of print as 40(1) 3] Detection and Clinical Significance of Lymph Node Micrometastasis in Gastric Cardia Adenocarcinoma Y RU, L ZHANG, Q CHEN, SG GAO, GP WANG, ZF QU, TY SHAN, N QIAN AND XS FENG Department of Oncology, Cancer Institute, First Affiliated Hospital of Henan University of Science and Technology, Luoyang, China OBJECTIVES: Lymph node micro metastasis was investigated in gastric cardia adenocarcinoma (GCA) patients without lymph node metastasis on routine pathological examination. The relationship between micrometastasis and clinicopathological features was also evaluated. METHODS: A total of 349 lymph nodes were obtained from 45 patients with GCA. Micrometastases were detected by immunohistochemical staining for the markers cytokeratin 19 (CK19) and CD44 variant 6 (CD44v6). RESULTS: A total of 33 lymph nodes (9.5%) from 15 patients (33.3%) were positive for CK19. Of these, 27 lymph nodes (7.7%) from 12 patients (26.7%) were also positive for CD44v6. Micrometastasis was significantly related to depth of tumour invasion and Lauren classification (intestinal or diffuse). The recurrence rate was significantly higher and 2-year survival rate significantly lower in patients with than in those without lymph node micrometastasis, showing the necessity of detecting micrometastasis in GCA patients who test negative for lymph node metastasis on routine examination. CONCLUSION: CK19 and CD44v6 were shown to be good markers for micrometastasis detection. KEY WORDS: GASTRIC CARDIA CARCINOMA; PROGNOSIS; LYMPH NODE MICROMETASTASIS; DETECTION; CYTOKERATIN 19; CD44 VARIANT 6; IMMUNOHISTOCHEMISTRY Introduction Metastasis is one of the fundamental biological characteristics of malignant tumours and is the leading cause of death in cancer patients. It is the result of a series of multiple intrinsically linked steps. Tumour micrometastasis, in which single, scattered or clustered cancer cells exist in tissues or organs outside those of the primary tumour, is an early stage in the development of metastatic spread. These transferred cells are usually not detectable by haematoxylin and eosin (H&E) staining or other routinely used methods. One of the most common malignancies in China is gastric carcinoma, for which the most important prognostic factor is lymph node metastasis. 1 3 Recent advances in immunohistochemical and molecular biology techniques have made it possible to detect lymph node micrometastasis not found on routine H&E evaluation. 4 8 Lymph node micrometastasis has an impact on the staging of gastric carcinoma and is a 293

2 significant risk factor in determining the prognosis of these patients. 9 In recent years the incidence of gastric cardia adenocarcinoma (GCA) has risen rapidly, whereas that of distal gastric adenocarcinoma has steadily decreased. These trends suggest that GCA is different in nature from distal gastric adenocarcinoma. There are a number of reports on lymph node micrometastasis in distal gastric adenocarcinoma 10,11 but little has been published on such micrometastases in GCA. Cytokeratin 19 (CK19), which originates from epithelial cells, is a good tissue-specific marker for epithelial tumour micro - metastasis and is highly expressed in the intestinal tract but not in normal lymph node tissue or blood. In addition, the cell surface adhesion molecule, CD44, has been gaining interest: CD44 variant 6 (CD44v6), a CD44 splicing variant, can influence tumour cell invasion and metastatic behaviour and shows tumour specificity. 12 In the present study, immunohisto - chemical staining with anti-ck19 and anti- CD44v6 monoclonal antibodies was performed to detect lymph node micrometastasis in GCA patients testing negative for lymph node metastasis on routine pathological examination. Possible correlated factors were investigated and the clinical significance of lymph node micrometastasis is discussed. Patients and methods PATIENTS Patients with no lymph node metastases were recruited from those with pathologically confirmed GCA undergoing gastrectomy and lymphadenectomy at the First Affiliated Hospital of Henan University of Science and Technology, Luoyang, China, between January 2004 and December None of the patients had received preoperative chemotherapy or radiotherapy. Patients were followed for up to 41 months; recurrence in the stomach and mortality rates during the follow-up period were recorded. All patients provided written informed consent for samples to be taken and the study protocol was approved by the Ethics Committee of the First Affiliated Hospital of Henan University of Science and Technology, Luoyang, China. TUMOUR EVALUATION Tumour size (defined as the maximum diameter of the surface of the primary tumour), the depth of invasion and the degree of differentiation, were recorded. Tumours were staged using the tumour, node, metastasis (TNM) classification 13 and histological type was determined, according to the Lauren classification of gastric adenocarcinomas, into intestinal and diffuse types. 14 HISTOPATHOLOGY Lymph nodes were collected from each patient, fixed in formalin, paraffinembedded and sliced (4 µm thick) for histopathological examination. One slice from each lymph node biopsy was then selected at random for H&E staining and examined under a microscope independently by two experts in biopsy film reading. Samples obtained during the surgical removal of benign gastric lesions were used as negative controls and those from GCA patients showing metastases on H&E examination were used as positive controls. IMMUNOHISTOCHEMISTRY Three slices (4 µm thick) cut from the formalin-fixed, paraffin-embedded lymph node specimens were used for immunohistochemical testing, using mouse 294

3 antihuman CD44v6 and CK19 monoclonal antibodies, with a streptavidin peroxidase kit (Fuzhou Maixin Biotechnology Development, Fuzhou, China) according to the manufacturer s instructions. The results were visualized using a diaminobenzidine chromogenic enzyme substrate kit (Fuzhou Maixin Biotechnology Development); CK19- positive and CD44v6-positive staining appeared as a brown/yellow coloration in the cell membrane and/or cytoplasm and was regarded as a definite positive result when found in two adjacent biopsies from the same specimen. A double-blind method was used to observe the results. Specimens staining positive for CK19 or CD44v6 were examined using a high-power ( 400) microscope to confirm the presence of micrometastases. STATISTICAL ANALYSES Calculation of the sample size required was determined using Power and Precision software (Biostat, Englewood, NJ, USA). Relationships between lymph node micrometastasis and clinicopathological parameters were investigated using the χ 2 - test. Survival of patients with GCA was evaluated using Kaplan Meier survival analysis and the log-rank test. A P-value < 0.05 was considered to be statistically significant. Data were analysed using SPSS version 17.0 (SPSS Inc., Chicago, IL, USA). The study was designed with the help of an expert statistician. Results A total of 45 patients with pathologically confirmed GCA with no lymph node metastases on routine pathological examination were included in the study. They comprised 36 men and nine women, ranging in age from 41 to 77 years, with a mean age of 62.6 years. Tumour diameter was 2 cm in 11 patients and > 2 cm in 34 patients. Tumours were staged as T 1 (n = 6), T 2 (n = 15), T 3 (n = 20) or T 4 (n = 4). On histopathological examination there were nine cases of welldifferentiated, 17 cases of moderately differentiated and 19 cases of poorly differentiated adenocarcinoma. A total of 349 lymph nodes were collected, giving a mean of 7.8 per patient. Ten lymph nodes from patients with benign gastric conditions (seven cases of gastric ulcer and three of leiomyoma) were used as negative controls. Two metastatic lymph nodes from GCA patients with positive H&E staining were used as positive controls. All 349 lymph node specimens were confirmed negative for metastases on H&E staining. A total of 33 lymph nodes (9.5%) from 15 patients (33.3%) were positive for CK19. Of these, 27 lymph nodes (7.7%) from 12 patients (26.7%) were also positive for CD44v6 (Fig. 1). Positive cells were either scattered singly or gathered in small groups of two, three or more cells in the lymph sinuses, mainly the marginal sinus. 15 All 10 control lymph nodes from patients with benign conditions were negative on H&E, CK19 and CD44v6 staining. The two control lymph nodes showing positive H&E staining were also positive for both CK19 and CD44v6. The relationships between lymph node micrometastasis and various clinicopathological features are shown in Table 1. The presence of CK19-positive or CD44v6-positive cells was significantly related to depth of invasion (P = and P = 0.046, respectively) and Lauren classification (P = and P = 0.007, respectively), but not to age, sex, tumour size or degree of differentiation. Three patients were lost to follow-up. The remaining 42 patients were followed up for 6 295

4 A B 25 µm 25 µm FIGURE 1: Lymph node sections from a patient with gastric cardia adenocarcinoma showing small clusters of cells immunohistochemically positive for (A) cytokeratin 19 or (B) CD44 variant 6 TABLE 1: Relationships between lymph node micrometastases, as indicated by the presence of cells positive for cytokeratin-19 (CK19) and CD44 variant 6 (CD44v6), and clinicopathological parameters in patients with gastric cardia adenocarcinoma CK19-positive CD44v6-positive Total No. of Statistical Statistical Parameter patients n significance n significance Sex NS NS Male Female Age NS NS < 50 years years Tumour size NS NS 2 cm > 2 cm Depth of invasion P = P = Mucosa Lamina muscularis mucosae Serous membrane Degree of differentiation NS NS Well differentiated Moderately differentiated Poorly differentiated Lauren classification P = P = Intestinal type Diffuse type NS, no statistically significant difference (P > 0.05; χ 2 -test). 41 months. Among the 15 patients with lymph node micrometastasis, recurrence occurred in seven (46.7%) and four died 6 25 months after surgery. Among the

5 patients without lymph node micrometastasis, recurrence occurred in one (3.7%); this patient died 14 months after surgery. The recurrence rate was significantly higher in the micrometastasis group than in the nonmicrometastasis group (χ 2 = 8.925, P = 0.003). In addition, the 2-year survival rate (63.6%) in the micrometastasis group was significantly lower than that in the nonmicrometastasis group (95.6%) (P = 0.011; Fig. 2). Discussion The occurrence of GCA and its evolution is a very complex process. Lymph node metastasis is the most important prognostic factor for GCA. 16 Determining the presence of lymph node metastasis is also important for postsurgical treatment staging. Lymph node micrometastasis, where tumour diameter is < 2 mm, is difficult to detect on routine pathological examination. Cytokeratins are components of epithelial cells and the intermediate filaments of epithelial cancer cells. They occur widely in epithelial cells but not in mesenchymal tissues. In the process of cell malignant transformation and tumorigenesis, keratin continues to exist in epithelial tumours, however mesenchymal cells fail to express keratin even after malignant transformation. This provides a theoretical basis for the idea that the presence of keratin in the digestive tract indicates that metastasis to the digestive tract has occurred. More than 20 kinds of cytokeratins have been discovered to date. CK19 is highly expressed in the digestive tract, but not in normal lymph node tissue or blood, and is a good tissue-specific marker for epithelial tumour micrometastasis. In recent years CD44, which is a typical cell surface adhesion molecule, has gained increasing interest. Its structure and function 100 Positive for LNM 80 Survival (%) Negative for LNM Survival time (months) FIGURE 2: Kaplan Meier survival curve for the patients with gastric cardia adenocarcinoma according to whether they were positive (n = 15) or negative (n = 27) for lymph node micrometastasis (LNM); the between-group 2-year survival rate differed significantly (63.6% versus 95.6%, P = 0.011) 297

6 undergo significant changes during the process of malignant transformation, affecting tumour cell invasion and transfer behaviour. CD44v6, a splicing variant of CD44, belongs to a class of single-chain membrane glycoproteins. It is involved in lymphocyte homing, cell adhesion and migration, as well as a number of other functional activities. Protein expression of CD44v6 has been shown to be related to disease progression, lymph node metastasis and prognosis in gastric carcinoma. 17,18 In the present study, micrometastasis indicated by the presence of CK19 with or without CD44v6 was seen in 33 lymph nodes (9.5%) from 15 patients (33.3%); this is consistent with the results of Yun et al. 10 We found that lymph node micrometastasis was correlated with the depth of invasion and Lauren classification: the micrometastasis rate was much higher in diffuse than in intestinal cancers. This finding may be explained by the association of an E- cadherin gene mutation with diffuse-type gastric cancer, which results in decreased cell adhesion and easily separated and aggressive tumour cells. 19 As in previous reports, 20,21 in the present study there was no significant correlation between lymph node micrometastasis and age, sex, tumour size or degree of tumour differentiation. Lee et al. 4 and Yasuda et al. 5 reported that the 5-year survival rate was lower in gastric cancer patients with lymph node micrometastasis than in those without. Other studies, however, have reported that lymph node micrometastasis is not associated with prognosis. 20 In the present study, the recurrence rate was higher and the 2-year survival rate lower in the micrometastasis group than in the nonmicrometastasis group. This suggests that the detection of lymph node micrometastasis enables accurate prognostic and recurrence predictions. It has been shown that lymph node micrometastasis can be seen even in the early stages of gastric cancer. 22 Endoscopic resection for early-stage gastric cancer must, therefore, be performed with utmost precision. Even though minimally invasive endoscopic treatment had been selected to treat early gastric cancer in the patients included the present study, it was possible that micrometastases were present. In conclusion, the results of the present study have demonstrated the need to test for micrometastasis in GCA patients who are negative for lymph node metastasis on routine examination, because the presence of micrometastasis is an important prognostic indicator. CK19 and CD44v6 were shown to be good markers for micrometastasis detection. Conflicts of interest The authors had no conflicts of interest to declare in relation to this article. Received for publication 15 June 2011 Accepted subject to revision 4 July 2011 Revised accepted 21 December 2011 Copyright 2012 Field House Publishing LLP References 1 Saito H, Fukumoto Y, Osaki T, et al: Prognostic significance of level and number of lymph node metastases in patients with gastric cancer. Ann Surg Oncol 2007; 14: Barbour AP, Rizk NP, Gonen M, et al: Lymphadenectomy for adenocarcinoma of the gastroesophageal junction (GEJ): impact of adequate staging on outcome. Ann Surg Oncol 2007; 14: Al-Moundhri MS, Al-Bahrani B, Burney IA, et al: The prognostic determinants of gastric cancer treatment outcome in Omani Arab patients. Oncology 2006; 70: Lee E, Chae Y, Kim I, et al: Prognostic relevance of immunohistochemically detected lymph 298

7 node micrometastasis in patients with gastric carcinoma. Cancer 2002; 94: Yasuda K, Adachi Y, Shiraishi N, et al: Prognostic effect of lymph node micrometastasis in patients with histologically node-negative gastric cancer. Ann Surg Oncol 2002; 9: Ajisaka H, Miwa K: Micrometastases in sentinel nodes of gastric cancer. Br J Cancer 2003; 89: Higashi H, Natsugoe S, Ishigami S, et al: Distribution of lymph node metastasis including micrometastasis in gastric cancer with submucosal invasion. World J Surg 2003; 27: Karube T, Ochiai T, Shimada H, et al: Detection of sentinel lymph nodes in gastric cancers based on immunohistochemical analysis of micrometastases. J Surg Oncol 2004; 87: Wu ZY, Li JH, Zhan WH, et al: Effect of lymph node micrometastases on prognosis of gastric carcinoma. World J Gastroenterol 2007; 13: Yun HY, Bandou E, Kawamura T, et al: Influence of micrometastasis on N stage in gastric cancer and clinical application. J Exp Clin Cancer Res 2005; 24: Kim JJ, Song KY, Hur H, et al: Lymph node micrometastasis in node negative early gastric cancer. Eur J Surg Oncol 2009; 35: Okayama H, Kumamoto K, Saitou K, et al: CD44v6, MMP-7 and nuclear Cdx2 are significant biomarkers for prediction of lymph node metastasis in primary gastric cancer. Oncol Rep 2009; 22: Edge SB, Byrd DR, Compton CC, et al: AJCC Cancer Staging Manual, 7th edn. New York: Springer, Lauren P: The two histological main types of gastric carcinoma: diffuse and so-called intestinal-type carcinoma. Acta Pathol Microbiol Scand 1965; 64: Zhao A, Li J, Sun W: Detection and significance of lymph node micrometastases in patients with histologically node-negative gastric carcinoma. Zhonghua Zhong Liu Za Zhi 2000; 22: [in Chinese, English abstract]. 16 Zhang CH, He YL, Zhan WH, et al: Multivariate prognostic analysis for patients with curative resection of gastric cardia cancer. Zhonghua Wei Chang Wai Ke Za Zhi 2006; 9: [in Chinese, English abstract]. 17 Yamaguchi A, Goi T, Yu J, et al: Expression of CD44v6 in advanced gastric cancer and its relationship to hematogenous metastasis and long-term prognosis. J Surg Oncol 2002; 79: Xin Y, Grace A, Gallagher MM, et al: CD44V6 in gastric carcinoma: a marker of tumor progression. Appl Immunohistochem Mol Morphol 2001; 9: Wu ZY, Zhan WH, Li JH, et al: Lymph node micrometastases and its correlation with the expression of E-cadherin in gastric carcinoma. Chin J Exp Surg 2005; 22: Choi HJ, Kim YK, Kim YH, et al: Occurrence and prognostic implications of micrometastasis in lymph nodes from patients with submucosal gastric carcinoma. J Ann Surg Oncol 2002; 9: Xia Q, Chen XL, Wang XW: Role of cytokeratin in determining the lymph node micrometastasis in gastric carcinoma. J Shandong University (Health Sciences) 2006; 44: Endo K, Kohnoe S, Okamura T, et al: Evaluation of endoscopic mucosal resection and nodal micrometastasis in pn0 submucosal gastric cancer. Oncol Rep 2005; 13: Author s address for correspondence Dr Xiao-shan Feng Department of Oncology, Cancer Institute, First Affiliated Hospital of Henan University of Science and Technology, 24 Jing Hua Road, Luoyang , Henan Province, China

Characterization and significance of MUC1 and c-myc expression in elderly patients with papillary thyroid carcinoma

Characterization and significance of MUC1 and c-myc expression in elderly patients with papillary thyroid carcinoma Characterization and significance of MUC1 and c-myc expression in elderly patients with papillary thyroid carcinoma Y.-J. Hu 1, X.-Y. Luo 2, Y. Yang 3, C.-Y. Chen 1, Z.-Y. Zhang 4 and X. Guo 1 1 Department

More information

Clinicopathological and prognostic differences between mucinous gastric carcinoma and signet-ring cell carcinoma

Clinicopathological and prognostic differences between mucinous gastric carcinoma and signet-ring cell carcinoma Original Article Clinicopathological and prognostic differences between mucinous gastric carcinoma and signet-ring cell carcinoma Zhaode Bu, Zhixue Zheng, Ziyu Li, Xiaojiang Wu, Lianhai Zhang, Aiwen Wu,

More information

Clinical significance of CD44 expression in children with hepatoblastoma

Clinical significance of CD44 expression in children with hepatoblastoma Clinical significance of CD44 expression in children with hepatoblastoma H.-Y. Cai 1 *, B. Yu 1 *, Z.-C. Feng 2, X. Qi 1 and X.-J. Wei 1 1 Department of General Surgery, General Hospital of Beijing Military

More information

Risk Factors and Tumor Recurrence in pt1n0m0 Gastric Cancer after Surgical Treatment

Risk Factors and Tumor Recurrence in pt1n0m0 Gastric Cancer after Surgical Treatment pissn : 293-582X, eissn : 293-5641 J Gastric Cancer 216;16(4):215-22 https://doi.org/1.523/jgc.216.16.4.215 Original Article Risk Factors and Tumor Recurrence in pt1nm Gastric Cancer after Surgical Treatment

More information

Satisfactory surgical outcome of T2 gastric cancer after modified D2 lymphadenectomy

Satisfactory surgical outcome of T2 gastric cancer after modified D2 lymphadenectomy Original Article Satisfactory surgical outcome of T2 gastric cancer after modified D2 lymphadenectomy Shupeng Zhang 1, Liangliang Wu 2, Xiaona Wang 2, Xuewei Ding 2, Han Liang 2 1 Department of General

More information

Gastric Cancer Histopathology Reporting Proforma

Gastric Cancer Histopathology Reporting Proforma Gastric Cancer Histopathology Reporting Proforma Mandatory questions (i.e. protocol standards) are in bold (e.g. S1.01). S1.01 Identification Family name Given name(s) Date of birth Sex Male Female Intersex/indeterminate

More information

Characteristics of intramural metastasis in gastric cancer. Tatsuya Hashimoto Kuniyoshi Arai Yuichi Yamashita Yoshiaki Iwasaki Tsunekazu

Characteristics of intramural metastasis in gastric cancer. Tatsuya Hashimoto Kuniyoshi Arai Yuichi Yamashita Yoshiaki Iwasaki Tsunekazu ORIGINAL ARTICLE Characteristics of intramural metastasis in gastric cancer Tatsuya Hashimoto Kuniyoshi Arai Yuichi Yamashita Yoshiaki Iwasaki Tsunekazu Hishima Author for correspondence: T. Hashimoto

More information

Clinicopathological Characteristics and Outcome Indicators of Stage II Gastric Cancer According to the Japanese Classification of Gastric Cancer

Clinicopathological Characteristics and Outcome Indicators of Stage II Gastric Cancer According to the Japanese Classification of Gastric Cancer Clinicopathological Characteristics and Outcome Indicators of Stage II Gastric Cancer According to the Japanese Classification of Gastric Cancer HITOSHI OJIMA 1, KEN-ICHIRO ARAKI 1, TOSHIHIDE KATO 1, KAORI

More information

Perigastric lymph node metastases in gastric cancer: comparison of different staging systems

Perigastric lymph node metastases in gastric cancer: comparison of different staging systems Gastric Cancer (1999) 2: 201 205 Original article 1999 by International and Japanese Gastric Cancer Associations Perigastric lymph node metastases in gastric cancer: comparison of different staging systems

More information

Expression and significance of Bmi-1 and Ki67 in colorectal carcinoma tissues

Expression and significance of Bmi-1 and Ki67 in colorectal carcinoma tissues [Chinese Journal of Cancer 27:12, 568-573; December Expression 2008]; 2008 and significance Sun Yat-sen of University Bmi-1 and Cancer Ki67 in Center colorectal carcinoma tissues Clinical Research Paper

More information

Clinicopathological significance of oestrogen receptor expression in non-small cell lung cancer

Clinicopathological significance of oestrogen receptor expression in non-small cell lung cancer Research Report Clinicopathological significance of oestrogen receptor expression in non-small cell lung cancer Journal of International Medical Research 2017, Vol. 45(1) 51 58! The Author(s) 2016 Reprints

More information

Micrometastasis in lymph nodes of mucosal gastric cancer

Micrometastasis in lymph nodes of mucosal gastric cancer Gastric Cancer (2000) 3: 91 96 2000 by International and Japanese Gastric Cancer Associations Original article Micrometastasis in lymph nodes of mucosal gastric cancer Jianhui Cai 1, Masahide Ikeguchi

More information

Peritoneal Involvement in Stage II Colon Cancer

Peritoneal Involvement in Stage II Colon Cancer Anatomic Pathology / PERITONEAL INVOLVEMENT IN STAGE II COLON CANCER Peritoneal Involvement in Stage II Colon Cancer A.M. Lennon, MB, MRCPI, H.E. Mulcahy, MD, MRCPI, J.M.P. Hyland, MCh, FRCS, FRCSI, C.

More information

Combined use of AFP, CEA, CA125 and CAl9-9 improves the sensitivity for the diagnosis of gastric cancer

Combined use of AFP, CEA, CA125 and CAl9-9 improves the sensitivity for the diagnosis of gastric cancer He et al. BMC Gastroenterology 2013, 13:87 RESEARCH ARTICLE Open Access Combined use of AFP, CEA, CA125 and CAl9-9 improves the sensitivity for the diagnosis of gastric cancer Chao-Zhu He 1,2, Kun-He Zhang

More information

ORIGINAL ARTICLE. International Journal of Surgery

ORIGINAL ARTICLE. International Journal of Surgery International Journal of Surgery (2013) 11(S1), S90 S94 Contents lists available at ScienceDirect International Journal of Surgery journal homepage: www.journal-surgery.net ORIGINAL ARTICLE Lymph node

More information

Chen et al. BMC Surgery 2014, 14:110

Chen et al. BMC Surgery 2014, 14:110 Chen et al. BMC Surgery 2014, 14:110 RESEARCH ARTICLE Open Access Cervical lymph node metastasis classified as regional nodal staging in thoracic esophageal squamous cell carcinoma after radical esophagectomy

More information

Title: Synuclein Gamma Predicts Poor Clinical Outcome in Colon Cancer with Normal Levels of Carcinoembryonic Antigen

Title: Synuclein Gamma Predicts Poor Clinical Outcome in Colon Cancer with Normal Levels of Carcinoembryonic Antigen Author's response to reviews Title: Synuclein Gamma Predicts Poor Clinical Outcome in Colon Cancer with Normal Levels of Carcinoembryonic Antigen Authors: Caiyun Liu (liucaiyun23@yahoo.com.cn) Bin Dong

More information

Prognostic Value of Plasma D-dimer in Patients with Resectable Esophageal Squamous Cell Carcinoma in China

Prognostic Value of Plasma D-dimer in Patients with Resectable Esophageal Squamous Cell Carcinoma in China 1663 Ivyspring International Publisher Research Paper Journal of Cancer 2016; 7(12): 1663-1667. doi: 10.7150/jca.15216 Prognostic Value of Plasma D-dimer in Patients with Resectable Esophageal Squamous

More information

Diagnostic and prognostic value of CEA, CA19 9, AFP and CA125 for early gastric cancer

Diagnostic and prognostic value of CEA, CA19 9, AFP and CA125 for early gastric cancer Feng et al. BMC Cancer (2017) 17:737 DOI 10.1186/s12885-017-3738-y RESEARCH ARTICLE Open Access Diagnostic and prognostic value of CEA, CA19 9, AFP and CA125 for early gastric cancer Fan Feng 1, Yangzi

More information

Prognostic implication of isolated tumor cells and micrometastases in regional lymph nodes of gastric cancer

Prognostic implication of isolated tumor cells and micrometastases in regional lymph nodes of gastric cancer PO Box 2345, Beijing 100023, China World J Gastroenterol 2005;11(38):5920-5925 www.wjgnet.com World Journal of Gastroenterology ISSN 1007-9327 wjg@wjgnet.com ELSEVIER 2005 The WJG Press and Elsevier Inc.

More information

RESEARCH ARTICLE. Qian Liu, Jian-Jun Bi, Yan-Tao Tian, Qiang Feng, Zhao-Xu Zheng, Zheng Wang* Abstract. Introduction. Materials and Methods

RESEARCH ARTICLE. Qian Liu, Jian-Jun Bi, Yan-Tao Tian, Qiang Feng, Zhao-Xu Zheng, Zheng Wang* Abstract. Introduction. Materials and Methods RESEARCH ARTICLE Outcome after Simultaneous Resection of Gastric Primary Tumour and Synchronous Liver Metastases: Survival Analysis of a Single-center Experience in China Qian Liu, Jian-Jun Bi, Yan-Tao

More information

Wen-Bin Shen 1, Hong-Mei Gao 2, Shu-Chai Zhu 1*, You-Mei Li 1, Shu-Guang Li 1 and Jin-Rui Xu 1

Wen-Bin Shen 1, Hong-Mei Gao 2, Shu-Chai Zhu 1*, You-Mei Li 1, Shu-Guang Li 1 and Jin-Rui Xu 1 Shen et al. World Journal of Surgical Oncology (2017) 15:192 DOI 10.1186/s12957-017-1259-4 RESEARCH Analysis of the causes of failure after radical surgery in patients with P T 3 N 0 M 0 thoracic esophageal

More information

Descriptor Definition Author s notes TNM descriptors Required only if applicable; select all that apply multiple foci of invasive carcinoma

Descriptor Definition Author s notes TNM descriptors Required only if applicable; select all that apply multiple foci of invasive carcinoma S5.01 The tumour stage and stage grouping must be recorded to the extent possible, based on the AJCC Cancer Staging Manual (7 th Edition). 11 (See Tables S5.01a and S5.01b below.) Table S5.01a AJCC breast

More information

Disclosures. Outline. What IS tumor budding?? Tumor Budding in Colorectal Carcinoma: What, Why, and How. I have nothing to disclose

Disclosures. Outline. What IS tumor budding?? Tumor Budding in Colorectal Carcinoma: What, Why, and How. I have nothing to disclose Tumor Budding in Colorectal Carcinoma: What, Why, and How Disclosures I have nothing to disclose Soo-Jin Cho, MD, PhD Assistant Professor UCSF Dept of Pathology Current Issues in Anatomic Pathology 2017

More information

Update on staging colorectal carcinoma, the 8 th edition AJCC. General overview of staging. When is staging required? 11/1/2017

Update on staging colorectal carcinoma, the 8 th edition AJCC. General overview of staging. When is staging required? 11/1/2017 Update on staging colorectal carcinoma, the 8 th edition AJCC Dale C. Snover, MD November 3, 2017 General overview of staging Reason for uniform staging Requirements to use AJCC manual and/or CAP protocols

More information

Quiz Adenocarcinoma of the distal stomach has been increasing in the last 20 years. a. True b. False

Quiz Adenocarcinoma of the distal stomach has been increasing in the last 20 years. a. True b. False Quiz 1 1. Which of the following are risk factors for esophagus cancer. a. Obesity b. Gastroesophageal reflux c. Smoking and Alcohol d. All of the above 2. Adenocarcinoma of the distal stomach has been

More information

Introduction. Keywords Staging system Survival outcome Gastric cancer Chinese patients

Introduction. Keywords Staging system Survival outcome Gastric cancer Chinese patients Gastric Cancer https://doi.org/10.1007/s10120-017-0779-5 ORIGINAL ARTICLE The 8th edition of the American Joint Committee on Cancer tumor node metastasis staging system for gastric cancer is superior to

More information

Towards a more personalized approach in the treatment of esophageal cancer focusing on predictive factors in response to chemoradiation Wang, Da

Towards a more personalized approach in the treatment of esophageal cancer focusing on predictive factors in response to chemoradiation Wang, Da University of Groningen Towards a more personalized approach in the treatment of esophageal cancer focusing on predictive factors in response to chemoradiation Wang, Da IMPORTANT NOTE: You are advised

More information

Correlation Between GATA-3, Ki67 and p53 Expressions to Histopathology Grading of Breast Cancer in Makassar, Indonesia

Correlation Between GATA-3, Ki67 and p53 Expressions to Histopathology Grading of Breast Cancer in Makassar, Indonesia Cancer Research Journal 2016; 4(3): 43-47 http://www.sciencepublishinggroup.com/j/crj doi: 10.11648/j.crj.20160403.11 ISSN: 2330-8192 (Print); ISSN: 2330-8214 (Online) Correlation Between GATA-3, Ki67

More information

Downregulation of long non-coding RNA LINC01133 is predictive of poor prognosis in colorectal cancer patients

Downregulation of long non-coding RNA LINC01133 is predictive of poor prognosis in colorectal cancer patients European Review for Medical and Pharmacological Sciences 2017; 21: 2103-2107 Downregulation of long non-coding RNA LINC01133 is predictive of poor prognosis in colorectal cancer patients J.-H. ZHANG 1,

More information

Greater Manchester & Cheshire Guidelines for Pathology Reporting for Oesophageal and Gastric Malignancy

Greater Manchester & Cheshire Guidelines for Pathology Reporting for Oesophageal and Gastric Malignancy Greater Manchester & Cheshire Guidelines for Pathology Reporting for Oesophageal and Gastric Malignancy Authors: Dr Gordon Armstrong, Dr Sue Pritchard 1. General Comments 1.1 Cancer reporting: Biopsies

More information

Biomedical Research 2017; 28 (21): ISSN X

Biomedical Research 2017; 28 (21): ISSN X Biomedical Research 2017; 28 (21): 9497-9501 ISSN 0970-938X www.biomedres.info Analysis of relevant risk factor and recurrence prediction model construction of thyroid cancer after surgery. Shuai Lin 1#,

More information

Poorly Differentiated, Solid-type Adenocarcinoma of the Stomach

Poorly Differentiated, Solid-type Adenocarcinoma of the Stomach Upsala Journal of Medical Sciences ISSN: 0300-9734 (Print) 2000-1967 (Online) Journal homepage: http://www.tandfonline.com/loi/iups20 Poorly Differentiated, Solid-type Adenocarcinoma of the Stomach Takashi

More information

In 1989, Deslauriers et al. 1 described intrapulmonary metastasis

In 1989, Deslauriers et al. 1 described intrapulmonary metastasis ORIGINAL ARTICLE Prognosis of Resected Non-Small Cell Lung Cancer Patients with Intrapulmonary Metastases Kanji Nagai, MD,* Yasunori Sohara, MD, Ryosuke Tsuchiya, MD, Tomoyuki Goya, MD, and Etsuo Miyaoka,

More information

Greater Manchester and Cheshire HPB Unit Guidelines for the Assessment & Management of Hepatobiliary and Pancreatic Disease Chapter 14

Greater Manchester and Cheshire HPB Unit Guidelines for the Assessment & Management of Hepatobiliary and Pancreatic Disease Chapter 14 Greater Manchester and Cheshire HPB Unit Guidelines for the Assessment & Management of Hepatobiliary and Pancreatic Disease Chapter 14 Contents 14. Neuroendocrine Tumours 161 14.1. Diagnostic algorithm

More information

Total Versus Subtotal Gastrectomy for Signet Ring Cell Carcinoma of the Stomach

Total Versus Subtotal Gastrectomy for Signet Ring Cell Carcinoma of the Stomach ORIGINAL ARTICLE Total Versus Subtotal Gastrectomy for Signet Ring Cell Carcinoma of the Stomach Ilker Murat Arer 1, Hakan Yabanoglu 1, Aydincan Akdur 2, Nezih Akkapulu 1 and Murat Kus 1 ABSTRACT Objective:

More information

Comparison of prognostic nomograms based on different nodal staging systems in patients with resected gastric cancer

Comparison of prognostic nomograms based on different nodal staging systems in patients with resected gastric cancer 950 Ivyspring International Publisher Research Paper Journal of Cancer 2017; 8(6): 950-958. doi: 10.7150/jca.17370 Comparison of prognostic nomograms based on different nodal staging systems in patients

More information

Metastatic mechanism of spermatic cord tumor from stomach cancer

Metastatic mechanism of spermatic cord tumor from stomach cancer Int Canc Conf J (2013) 2:191 195 DOI 10.1007/s13691-013-0-9 CANCER BOARD CONFERENCE Metastatic mechanism of spermatic cord tumor from stomach cancer Masahiro Seike Yoshikazu Kanazawa Ryuji Ohashi Tadashi

More information

Prognostic Factors for Node-Negative Advanced Gastric Cancer after Curative Gastrectomy

Prognostic Factors for Node-Negative Advanced Gastric Cancer after Curative Gastrectomy pissn : 293-582X, eissn : 293-564 J Gastric Cancer 26;6(3):6-66 http://dx.doi.org/.523/jgc.26.6.3.6 Original Article Prognostic Factors for Node-Negative Advanced Gastric Cancer after Curative Gastrectomy

More information

Translating Evidence into Practice: Primary Cutaneous Melanoma Guidelines. Sentinel Lymph Node Biopsy

Translating Evidence into Practice: Primary Cutaneous Melanoma Guidelines. Sentinel Lymph Node Biopsy American Academy of Dermatology 2018 Annual Meeting San Diego, CA, February 17, 2018 Translating Evidence into Practice: Primary Cutaneous Melanoma Guidelines. Sentinel Lymph Node Biopsy Christopher Bichakjian,

More information

NPQR Quality Payment Program (QPP) Measures 21_18247_LS.

NPQR Quality Payment Program (QPP) Measures 21_18247_LS. NPQR Quality Payment Program (QPP) Measures 21_18247_LS MEASURE ID: QPP 99 MEASURE TITLE: Breast Cancer Resection Pathology Reporting pt Category (Primary Tumor) and pn Category (Regional Lymph Nodes)

More information

COLORECTAL CANCER: PROGNOSTIC VALUES

COLORECTAL CANCER: PROGNOSTIC VALUES & COLORECTAL CANCER: PROGNOSTIC VALUES Suzana Manxhuka-Kerliu¹*, Skender Telaku², Halil Ahmetaj³, Arijeta Baruti¹, Sadushe Loxha¹, Agron Kerliu³ ¹ Institute of Pathology, Faculty of Medicine, University

More information

Reduced Lymph Node Harvest after Neoadjuvant Chemotherapy in Gastric Cancer

Reduced Lymph Node Harvest after Neoadjuvant Chemotherapy in Gastric Cancer The Journal of International Medical Research 2011; 39: 2086 2095 Reduced Lymph Node Harvest after Neoadjuvant Chemotherapy in Gastric Cancer Z-M WU 1, R-Y TENG 2, J-G SHEN 2, S-D XIE 2, C-Y XU 2,3 AND

More information

Ratio of maximum standardized uptake value to primary tumor size is a prognostic factor in patients with advanced non-small cell lung cancer

Ratio of maximum standardized uptake value to primary tumor size is a prognostic factor in patients with advanced non-small cell lung cancer Original Article Ratio of maximum standardized uptake value to primary tumor size is a prognostic factor in patients with advanced non-small cell lung cancer Fangfang Chen 1 *, Yanwen Yao 2 *, Chunyan

More information

VULVAR CARCINOMA. Page 1 of 5

VULVAR CARCINOMA. Page 1 of 5 VULVAR CARCINOMA EXAMPLE OF A VULVAR CARCINOMA USING PROPOSED TEMPLATE Case: Invasive squamous cell carcinoma arising in D-VIN Tumor in left labia major Left partial vaginectomy and sentinel lymph node

More information

c-erbb-2 expression and prognosis of gastric cancer: a meta-analysis

c-erbb-2 expression and prognosis of gastric cancer: a meta-analysis c-erbb-2 expression and prognosis of gastric cancer: a meta-analysis Z.Q. Wang and B.J. Sun Department of Surgery, Affiliated Tongren Hospital, Shanghai Jiaotong University, Shanghai, China Corresponding

More information

Case Scenario year-old white male presented to personal physician with dyspepsia with reflux.

Case Scenario year-old white male presented to personal physician with dyspepsia with reflux. Case Scenario 1 57-year-old white male presented to personal physician with dyspepsia with reflux. 7/12 EGD: In the gastroesophageal junction we found an exophytic tumor. The tumor occupies approximately

More information

Mucosal Esophageal Squamous Cell Carcinoma With Intramural Gastric Metastasis Invading Liver and Pancreas: A Case Report

Mucosal Esophageal Squamous Cell Carcinoma With Intramural Gastric Metastasis Invading Liver and Pancreas: A Case Report Int Surg 2014;99:458 462 DOI: 10.9738/INTSURG-D-13-00069.1 Case Report Mucosal Esophageal Squamous Cell Carcinoma With Intramural Gastric Metastasis Invading Liver and Pancreas: A Case Report Nobuhiro

More information

Coordinate Expression of Cytokeratins 7 and 20 in Prostate Adenocarcinoma and Bladder Urothelial Carcinoma

Coordinate Expression of Cytokeratins 7 and 20 in Prostate Adenocarcinoma and Bladder Urothelial Carcinoma Anatomic Pathology / CYTOKERATINS 7 AND 20 IN PROSTATE AND BLADDER CARCINOMAS Coordinate Expression of Cytokeratins 7 and 20 in Prostate Adenocarcinoma and Bladder Urothelial Carcinoma Nader H. Bassily,

More information

Urinary Bladder: WHO Classification and AJCC Staging Update 2017

Urinary Bladder: WHO Classification and AJCC Staging Update 2017 Urinary Bladder: WHO Classification and AJCC Staging Update 2017 Houston Society of Clinical Pathologists 58 th Annual Spring Symposium Houston, TX April 8, 2017 Jesse K. McKenney, MD Classification

More information

Case Scenario 1. The patient has now completed his neoadjuvant chemoradiation and has been cleared for surgery.

Case Scenario 1. The patient has now completed his neoadjuvant chemoradiation and has been cleared for surgery. Case Scenario 1 July 10, 2010 A 67-year-old male with squamous cell carcinoma of the mid thoracic esophagus presents for surgical resection. The patient has completed preoperative chemoradiation. This

More information

Histopathology: Colorectal polyps and carcinoma

Histopathology: Colorectal polyps and carcinoma Histopathology: Colorectal polyps and carcinoma These presentations are to help you identify, and to test yourself on identifying, basic histopathological features. They do not contain the additional factual

More information

Prognostic factors in patients with thoracic esophageal carcinoma staged pt 1-4a N 0 M 0 undergone esophagectomy with three-field lymphadenectomy

Prognostic factors in patients with thoracic esophageal carcinoma staged pt 1-4a N 0 M 0 undergone esophagectomy with three-field lymphadenectomy Original Article Page 1 of 7 Prognostic factors in patients with thoracic esophageal carcinoma staged pt 1-4a N 0 M 0 undergone esophagectomy with three-field lymphadenectomy Xiaohui Chen 1, Junqiang Chen

More information

ORIGINAL ARTICLE. Valeria Barresi & Luca Reggiani Bonetti & Giovanni Branca & Carmela Di Gregorio & Maurizio Ponz de Leon & Giovanni Tuccari

ORIGINAL ARTICLE. Valeria Barresi & Luca Reggiani Bonetti & Giovanni Branca & Carmela Di Gregorio & Maurizio Ponz de Leon & Giovanni Tuccari DOI 10.1007/s00428-012-1326-8 ORIGINAL ARTICLE Colorectal carcinoma grading by quantifying poorly differentiated cell clusters is more reproducible and provides more robust prognostic information than

More information

Esophageal cancer is the eighth most common cancer worldwide.

Esophageal cancer is the eighth most common cancer worldwide. Original Article Prognostic Value of Bone Marrow Micrometastasis in Patients with Operable Esophageal Squamous Cell Carcinoma A Long-Term Follow-Up Study Shao-bin Chen, MD,* Xiao-dong Su, MD,* Guo-wei

More information

Although metastasis in regional lymph nodes is one of

Although metastasis in regional lymph nodes is one of Nodal Occult Metastasis in Patients With Peripheral Lung Adenocarcinoma of 2.0 cm or Less in Diameter Jian Wu, MD, Yasuhiko Ohta, MD, Hiroshi Minato, MD, Yoshio Tsunezuka, MD, Makoto Oda, MD, Yoh Watanabe,

More information

High risk stage II colon cancer

High risk stage II colon cancer High risk stage II colon cancer Joel Gingerich, MD, FRCPC Assistant Professor Medical Oncologist University of Manitoba CancerCare Manitoba Disclaimer No conflict of interests 16 October 2010 Overview

More information

Author's response to reviews

Author's response to reviews Author's response to reviews Title: Estimation of groin recurrence risk in patients with squamous cell vulvar carcinoma by the assessment of marker gene expression in the lymph nodes. Authors: Magdalena

More information

Cancer staging system is commonly used to unify clinicopathological

Cancer staging system is commonly used to unify clinicopathological Original Article Proposed Modification of Nodal Staging as an Alternative to the Seventh Edition of the American Joint Committee on Cancer Tumor-Node-Metastasis Staging System Improves the Prognostic Prediction

More information

Rare Small Cell Carcinoma in Genitourinary Tract: Experience from E-Da Hospital

Rare Small Cell Carcinoma in Genitourinary Tract: Experience from E-Da Hospital E-Da Medical Journal 20;():-5 Original Article Rare Small Cell Carcinoma in Genitourinary Tract: Experience from E-Da Hospital Wei-Ting Kuo, I-Wei Chang2, Kevin Lu, Hua-Pin Wang, Tsan-Jung u, Victor C.

More information

Bone Metastases in Muscle-Invasive Bladder Cancer

Bone Metastases in Muscle-Invasive Bladder Cancer Journal of the Egyptian Nat. Cancer Inst., Vol. 18, No. 3, September: 03-08, 006 AZZA N. TAHER, M.D.* and MAGDY H. KOTB, M.D.** The Departments of Radiation Oncology* and Nuclear Medicine**, National Cancer

More information

Prostate cancer ~ diagnosis and impact of pathology on prognosis ESMO 2017

Prostate cancer ~ diagnosis and impact of pathology on prognosis ESMO 2017 Prostate cancer ~ diagnosis and impact of pathology on prognosis ESMO 2017 Dr Puay Hoon Tan Division of Pathology Singapore General Hospital Prostate cancer (acinar adenocarcinoma) Invasive carcinoma composed

More information

Original Article Effect of splenectomy on the survival of patients underwent radical surgery for gastric cardia cancer

Original Article Effect of splenectomy on the survival of patients underwent radical surgery for gastric cardia cancer Int J Clin Exp Med 2016;9(11):22217-22221 www.ijcem.com /ISSN:1940-5901/IJCEM0030103 Original Article Effect of splenectomy on the survival of patients underwent radical surgery for gastric cardia cancer

More information

EXPERIMENTAL AND THERAPEUTIC MEDICINE 8: , 2014

EXPERIMENTAL AND THERAPEUTIC MEDICINE 8: , 2014 EXPERIMENTAL AND THERAPEUTIC MEDICINE 8: 769-774, 2014 Helicobacter pylori infection promotes the invasion and metastasis of gastric cancer through increasing the expression of matrix metalloproteinase

More information

Clinical study on postoperative recurrence in patients with pn0 esophageal squamous cell carcinoma

Clinical study on postoperative recurrence in patients with pn0 esophageal squamous cell carcinoma Guo et al. Journal of Cardiothoracic Surgery 2014, 9:150 RESEARCH ARTICLE Open Access Clinical study on postoperative recurrence in patients with pn0 esophageal squamous cell carcinoma Xu-feng Guo, Teng

More information

Esophageal cancer: Biology, natural history, staging and therapeutic options

Esophageal cancer: Biology, natural history, staging and therapeutic options EGEUS 2nd Meeting Esophageal cancer: Biology, natural history, staging and therapeutic options Michael Bau Mortensen MD, Ph.D. Associate Professor of Surgery Centre for Surgical Ultrasound, Upper GI Section,

More information

Primary enteric adenocarcinoma with predominantly signet ring features of the lung: A case report with clinicopathological and molecular findings

Primary enteric adenocarcinoma with predominantly signet ring features of the lung: A case report with clinicopathological and molecular findings CASE REPORT Primary enteric adenocarcinoma with predominantly signet ring features of the lung: A case report with clinicopathological and molecular findings Makoto Nagashima 1, Ayako Moriyama 1, Yasuo

More information

Kidney Case 1 SURGICAL PATHOLOGY REPORT

Kidney Case 1 SURGICAL PATHOLOGY REPORT Kidney Case 1 Surgical Pathology Report February 9, 2007 Clinical History: This 45 year old woman was found to have a left renal mass. CT urography with reconstruction revealed a 2 cm medial mass which

More information

Polypoid Melanoma, A Virulent Variant of the Nodular Growth Pattern

Polypoid Melanoma, A Virulent Variant of the Nodular Growth Pattern Polypoid Melanoma, A Virulent Variant of the Nodular Growth Pattern ELIZABETH A. MANCI, M.D., CHARLES M. BALCH, M.D..TARIQ M. MURAD, M.D., PH.D., AND SENG/JAW SOONG, PH.D. Manci, Elizabeth A., Balch, Charles

More information

Proceedings of the 36th World Small Animal Veterinary Congress WSAVA

Proceedings of the 36th World Small Animal Veterinary Congress WSAVA www.ivis.org Proceedings of the 36th World Small Animal Veterinary Congress WSAVA Oct. 14-17, 2011 Jeju, Korea Next Congress: Reprinted in IVIS with the permission of WSAVA http://www.ivis.org 14(Fri)

More information

Protocol for the Examination of Specimens From Patients With Merkel Cell Carcinoma of the Skin

Protocol for the Examination of Specimens From Patients With Merkel Cell Carcinoma of the Skin Protocol for the Examination of Specimens From Patients With Merkel Cell Carcinoma of the Skin Version: Protocol Posting Date: June 2017 Includes ptnm requirements from the 8 th Edition, AJCC Staging Manual

More information

Central Poorly Differentiated Adenocarcinoma of the Maxilla: Report of a Case

Central Poorly Differentiated Adenocarcinoma of the Maxilla: Report of a Case Kobe J. Med. Sci., Vol. 49, No. 2, pp. 45-49, 2003 Central Poorly Differentiated Adenocarcinoma of the Maxilla: Report of a Case MASAHIRO UMEDA 1), SATOSHI YOKOO 1), YASUYUKI SHIBUYA 1), TAKAHIDE KOMORI

More information

Michael A. Choti, MD, FACS Department of Surgery Johns Hopkins Medicine, Baltimore, MD

Michael A. Choti, MD, FACS Department of Surgery Johns Hopkins Medicine, Baltimore, MD Michael A. Choti, MD, FACS Department of Surgery Johns Hopkins Medicine, Baltimore, MD Surgical Therapy of Gastric Cancer CLINICAL QUESTIONS 1. How much of the stomach should be removed? 2. How many lymph

More information

Pathology of the Urachus

Pathology of the Urachus Pathology of the Urachus Gladell P. Paner, MD, (BS) MT Departments of Pathology and Surgery, Section of Urology University of Chicago, Chicago, IL USA Gladell.paner@uchospitals.edu Updates in Epithelial

More information

AJCC 8 th edition update*: Colorectal cancer

AJCC 8 th edition update*: Colorectal cancer AJCC 8 th edition update*: Colorectal cancer Dr Caroline Cooper Pathology Queensland- Princess Alexandra Hospital, Brisbane * and other prognostic controversies Chapter 20 Colorectal adenocarcinoma High

More information

Safety and efficacy of endoscopic submucosal dissection for early gastric remnant cancers post-proximal gastrectomy with jejunal interposition

Safety and efficacy of endoscopic submucosal dissection for early gastric remnant cancers post-proximal gastrectomy with jejunal interposition Omori et al. 47 CASE REPORT SERIES PEER REVIEWED OPEN ACCESS Safety and efficacy of endoscopic submucosal dissection for early gastric remnant cancers post-proximal gastrectomy with jejunal interposition

More information

Analysis of clinical characteristics and prognosis of patients with anaplastic lymphoma kinase-positive and surgically resected lung adenocarcinoma

Analysis of clinical characteristics and prognosis of patients with anaplastic lymphoma kinase-positive and surgically resected lung adenocarcinoma Thoracic Cancer ISSN 1759-7706 ORIGINAL ARTICLE Analysis of clinical characteristics and prognosis of patients with anaplastic lymphoma kinase-positive and surgically resected lung adenocarcinoma Hong

More information

Prognosis of esophageal squamous cell carcinoma patients with preoperative radiotherapy: Comparison of different cancer staging systems

Prognosis of esophageal squamous cell carcinoma patients with preoperative radiotherapy: Comparison of different cancer staging systems Thoracic Cancer ISSN 1759-7706 ORIGINAL ARTICLE Prognosis of esophageal squamous cell carcinoma patients with preoperative radiotherapy: Comparison of different cancer staging systems Qifeng Wang 1 *,

More information

FDG-PET/CT in Gynaecologic Cancers

FDG-PET/CT in Gynaecologic Cancers Friday, August 31, 2012 Session 6, 9:00-9:30 FDG-PET/CT in Gynaecologic Cancers (Uterine) cervical cancer Endometrial cancer & Uterine sarcomas Ovarian cancer Little mermaid (Edvard Eriksen 1913) honoring

More information

Please Silence Your Cell Phones. Thank You

Please Silence Your Cell Phones. Thank You Please Silence Your Cell Phones Thank You TUMOR BUDDING IN PRE OPERATIVE BIOPSIES AND RESECTIONS Alessandro Lugli, MD Institute of Pathology and Translational Research Unit (TRU) University of Bern Bern,

More information

following radiotherapy

following radiotherapy British Journal of Cancer (1995) 72, 1536-154 r) 1995 Stockton Press All rights reserved 7-92/95 $12. Serum tumour markers in carcinoma of the uterine cervix and outcome following radiotherapy ARM Sproston',

More information

Definition of Synoptic Reporting

Definition of Synoptic Reporting Definition of Synoptic Reporting The CAP has developed this list of specific features that define synoptic reporting formatting: 1. All required cancer data from an applicable cancer protocol that are

More information

Low levels of serum mir-99a is a predictor of poor prognosis in breast cancer

Low levels of serum mir-99a is a predictor of poor prognosis in breast cancer Low levels of serum mir-99a is a predictor of poor prognosis in breast cancer J. Li 1, Z.J. Song 2, Y.Y. Wang 1, Y. Yin 1, Y. Liu 1 and X. Nan 1 1 Tumor Research Department, Shaanxi Provincial Tumor Hospital,

More information

Melanoma-Back to Basics I Thought I Knew Ya! Paul K. Shitabata, M.D. Dermatopathologist APMG

Melanoma-Back to Basics I Thought I Knew Ya! Paul K. Shitabata, M.D. Dermatopathologist APMG Melanoma-Back to Basics I Thought I Knew Ya! Paul K. Shitabata, M.D. Dermatopathologist APMG At tumor board, a surgeon insists that all level II melanomas are invasive since they have broken through the

More information

Hiroyuki Hanakawa, Nobuya Monden, Kaori Hashimoto, Aiko Oka, Isao Nozaki, Norihiro Teramoto, Susumu Kawamura

Hiroyuki Hanakawa, Nobuya Monden, Kaori Hashimoto, Aiko Oka, Isao Nozaki, Norihiro Teramoto, Susumu Kawamura Accepted Manuscript Radiation-induced laryngeal angiosarcoma: Case report Hiroyuki Hanakawa, Nobuya Monden, Kaori Hashimoto, Aiko Oka, Isao Nozaki, Norihiro Teramoto, Susumu Kawamura PII: S2468-5488(18)30005-5

More information

Supplemental Information

Supplemental Information Supplemental Information Prediction of Prostate Cancer Recurrence using Quantitative Phase Imaging Shamira Sridharan 1, Virgilia Macias 2, Krishnarao Tangella 3, André Kajdacsy-Balla 2 and Gabriel Popescu

More information

Prognostic correlation of breast neoplasm with MAGS (Microscopic Angiogenesis Grading System) score

Prognostic correlation of breast neoplasm with MAGS (Microscopic Angiogenesis Grading System) score Original article: Prognostic correlation of breast neoplasm with MAGS (Microscopic Angiogenesis Grading System) score 1 Dr. Vinita Singh*, 2 Dr. Suresh Singh, 3 Dr. Aseem Kapadia 1Assistant Professor,

More information

Tumor necrosis is a strong predictor for recurrence in patients with pathological T1a renal cell carcinoma

Tumor necrosis is a strong predictor for recurrence in patients with pathological T1a renal cell carcinoma ONCOLOGY LETTERS 9: 125-130, 2015 Tumor necrosis is a strong predictor for recurrence in patients with pathological T1a renal cell carcinoma KEIICHI ITO 1, KENJI SEGUCHI 1, HIDEYUKI SHIMAZAKI 2, EIJI TAKAHASHI

More information

Prognostic significance of overexpressed long non-coding RNA TUG1 in patients with clear cell renal cell carcinoma

Prognostic significance of overexpressed long non-coding RNA TUG1 in patients with clear cell renal cell carcinoma European Review for Medical and Pharmacological Sciences 2017; 21: 82-86 Prognostic significance of overexpressed long non-coding RNA TUG1 in patients with clear cell renal cell carcinoma P.-Q. WANG, Y.-X.

More information

ANTICANCER RESEARCH 28: (2008)

ANTICANCER RESEARCH 28: (2008) Comparative Analysis of Four Histopathological Classification Systems to Discriminate Benign and Malignant Behaviour in Gastrointestinal Stromal Tumors D. VALLBÖHMER 1, H.E. MARCUS 1, S.E. BALDUS 2, J.

More information

Uncommon secondary tumour of the stomach

Uncommon secondary tumour of the stomach Uncommon secondary tumour of the stomach B. Bancel, Hôpital CROIX ROUSSE LYON Bucharest Nov 2013 Case report 33-year old man Profound mental retardation and motor disturbances (sequelae of neonatal meningeal

More information

Revisit of Primary Malignant Neoplasms of the Trachea: Clinical Characteristics and Survival Analysis

Revisit of Primary Malignant Neoplasms of the Trachea: Clinical Characteristics and Survival Analysis Jpn J Clin Oncol 1997;27(5)305 309 Revisit of Primary Malignant Neoplasms of the Trachea: Clinical Characteristics and Survival Analysis -, -, - - 1 Chest Department and 2 Section of Thoracic Surgery,

More information