Stephen Finn University of Dublin Trinity College and St. James s Hospital, Dublin, Ireland

Size: px
Start display at page:

Download "Stephen Finn University of Dublin Trinity College and St. James s Hospital, Dublin, Ireland"

Transcription

1 Evaluation of NGS and other methods for ALK translocation detection in NSCLC patients in Europe: results of the European Thoracic Oncology Platform (ETOP) Lungscape Project Stephen Finn University of Dublin Trinity College and St. James s Hospital, Dublin, Ireland

2 Disclosures Commercial research support: Janssen and Astellas Honoraria: Merck, Pfizer, Astra Zeneca, Roche, Boehringer Ingelheim, BMS

3 Current ALK testing ALK translocation: 2 7% inversion or translocation of chromosome 2p resulting in transforming fusion gene targetable by TKI Reported prevalence varies across studies as a consequence of patient-selection criteria and detection methodology FISH and, now, IHC are widely used However, RT-PCR is possible, and NGS is the emerging major testing platform because of the possibility to detect multiple biomarkers using both DNA and RNA (EGFR, KRAS, BRAF, HER2 mutation, ALK, ROS1, RET, NTRK1 3) Question of LDTs vs CE-IVD also in the mix for laboratories to consider ALK, anaplastic lymphoma kinase; BRAF, B-Raf proto-oncogene; CE-IVD, Conformité Européene in vitro diagnostics; DNA, deoxyribonucleic acid; EGFR, epidermal growth factor receptor; FISH, fluorescent in-situ hybridization; HER2, human epidermal growth factor receptor 2; IHC, immunohistochemistry; KRAS, Kirsten rat sarcoma viral oncogene homologue; LDTs, laboratory developed tests; NGS, next generation sequencing; NTRK1 3, neurotrophic receptor tyrosine kinase 1 3; RET, rearranged during transfection; RNA, ribonucleic acid; ROS1, reactive oxygen species 1; RT-PCR, reverse transcription-polymerase chain reaction; TKI, tyrosine kinase inhibitor. Soda M et al. Nature. 2007;448: Wojas-Krawczyk K, et al. Contemp Oncol. 2013;17:

4 Lungscape Translational research program Designed, implemented, and conducted by ETOP Involving leading hospitals across Europe and beyond Multiple decentralized biobanks Virtual central ibiobank EQA Follow-up EQA, external quality assessment; ETOP, European Thoracic Oncology Platform. Available from: view=article&id=115523&itemid=197. Accessed August 2017.

5 Prevalence and clinical outcomes for patients with ALK-positive resected stage 1 to 3 adenocarcinoma: results from the European Thoracic Oncology Platform Lungscape Project Retrospective surgical cohort 16 European centers 1,281 patients screened (adenocarcinoma only) 6.2% positive by IHC 2.2% (at least) positive by FISH IHC is proposed as a screening tool for further FISH assessment H-score cut-off of 120 for 5A4 clone Blackhall FH, et al. J Clin Oncol. 2014;32:

6 Current study A comparison of multiple technologies for assessment of ALK status in the cohort published in 2014 A unique opportunity to assess in a large European cohort Refine and optimize diagnostic strategies

7 Methods 96 cases selected from ETOP Lungscape ibiobank 1,772 screened by IHC stage 1 3 based on any degree of IHC staining 5A4 (Novocastra, UK) decentralized, EQA-controlled FISH on all cases with positive staining decentralized, EQA-controlled RT-PCR for most frequent fusions centralized Targeted NGS centralized Oncomine Solid Tumour Fusion Transcript kit* screens for 70 ALK, RET, and ROS1-specific fusion transcripts novel ALK translocations using 3 5 ALK gene expression assay Macro-dissection for enrichment The same RNA used for both NGS and RT-PCR NSCLC, non-small-cell lung cancer. *IVD.For In vitro Diagnostc Use

8 3 5 assay for targeted NGS The assay measures the difference in expression between the 5 assay and the 3 assay of the ALK gene Samples that do not contain a fusion are expected to have similar expression of the 5 assay compared with the 3 assay of the driver gene Samples that contain a fusion are often expected to have elevated expression of the 3 assay compared with the 5 assay The 3 5 assay is therefore included for 2 alternate purposes to confirm a specific fusion to screen for a fusion other than those specifically sequenced No evidence Uncertain Strong evidence ALK

9 Results 1 IHC screen primary selection criterion (n = 96) IHC H-score 120 positive (n = 23) FISH 88 cases: 24 positive, 64 negative Tumour cellularity median 70% (range 10 90) RNA yield: median 47 ng/μl (range 9 300) RT-PCR successful in 77 of 96 cases (80.2%) B-actin-amplified ALK rearrangement detected in 16 cases RT-PCR Negative: 61 (79.2%) Positive: 16 (20.8%) Not available: 19 (19.8% of 96) Negative: 64 (72.7%) Positive: 24 (27.3%) Not available: 8 (8.3% of 96) 96 ETOP Lungscape cases Negative: 67 (74.4%) Positive: 23 (25.6%) 1+: 58 (60.4%) 2+: 16 (16.7%) 3+: 22 (22.9%) NGS Not available: 6 (6.3% of 96) FISH IHC level H-score < 120: 69 (75.0%) 120: 23 (25.0%) Not available: 4 (4.2% of 96) 70 cases with available results for all 4 methods

10 Results 2 Targeted NGS 95 cases analysed and passed initial QC Specific ALK rearrangement detected in 15 cases Imbalance assay performed on remaining cases 6 cases: strong evidence of imbalance 11 cases: uncertain (considered failed assays) 63 cases: no evidence finally 77 cases accepted 21 positive and 56 negative 3 5 Assay Specific ALK assay Positive For imbalance No evidence Uncertain Strong evidence QC, quality control.

11 Box-plots of 3 5 assay scores by ALK status assay scores Negative Positive Note 1: ALK status is defined by the concordant result of at least 2 of the 3 other methods: RT-PCR, FISH, IHC H-scoring. Note 2: 4 extreme outliers (with values of 1.96, 0.82, 0.71, 0.21) are excluded from the display of negative group.

12 Concordance of methodologies H-score not tested NGS-positive NGS-positive (strong imb. only) NGS-negative NGS failed (uncertain imb.) NGS failed NGS not tested for imb. FISH-positive FISH-negative FISH not tested RT-PCR-positive RT-PCR-negative RT-PCR not tested 200 H-score FISH RT-PCR IHC

13 Variants detected E13A20 4 E20A20 1 E6aA20 3 E6bA20 1 E6(a/b)A20 E6(a/b/b)A Strong imbalance

14 Summary: defining a gold standard Joint concordance of all 4 methods evaluable in 60 cases 55 cases showed full agreement Gold standard to determine sensitivity and specificity gold standard positivity was defined as positive using both IHC-positive threshold (H-score > 120) and FISH positivity evaluable in 82 cases Gold standard positive Sensitivity (%) Specificity (%) NGS RT-PCR 70 79

15 Conclusions NGS is a useful screening tool for ALK rearrangement status, superior to RT-PCR when RNA yield is limited When using NGS, it is critically important to integrate the 3 5 assay and to confirm with one or more additional methods in the imbalance cases These data further highlight the possibility of missing actionable rearrangements when only one screening methodology is available

16 Conclusions (cont.) If maximal sensitivity and specificity for ALK rearrangement detection are sought, confirmation of ALK status using 2 techniques or more in discordant cases is mandatory Accepted and recommended IHC should be the first step (inexpensive and easy technique for screening out negative cases); further confirmation by a molecular technique FISH (cytogenetics) or RT-PCR vs NGS (RNA-based techniques) should ideally follow In discordant cases, a third type of assay could be applied

17 Proposal ALK assessment 2 techniques of: NGS, IHC, and/or FISH Concordant Concordant+ Discordant No ALK rearrangement ALK rearrangement present Third technique

18 Panel testing More information DNA BRAF, HER2 exon 20, MET exon 14, KRAS, EGFR RNA RET, ROS1, NTRK, MET exon 14 Quality assurance Optimal use of scant material Access to clinical trials

19 ETOP NGS ALK I. Letovanec 1 *, S. Finn 2 *, P. Zygoura 3, P. Smyth 2, A. Soltermann 4, L. Bubendorf 5, E.-J. Speel 6, A. Marchetti 7, D. Nonaka 8, K. Monkhorst 9, H. Hager 10, M. Martorell 11, A. Sejda 12, R. Cheney 13, J. Hernandez-Losa 14, E. Verbeken 15, W. Weder 4, S. Savic 5, A. Di Lorito 7, A. Navarro 11, E. Felip 16, A. Warth 17, P. Baas 18, P. Meldgaard 10, F. Blackhall 19, A.-M. Dingemans 6, H. Dienemann 17, R. Dziadziuszko 20, J. Vansteenkiste 15, Cathal O'Brien 2, T. Geiger 21, J. Sherlock 22, J. Schageman 23, U. Dafni 24, R. Kammler 21, K.M. Kerr 25, E. Thunnissen 26, R. Stahel 27, S. Peters 1 on behalf of the ETOP Lungscape Consortium 21 1 Centre Hospitalier Universitaire Vaudois CHUV, Lausanne/Switzerland, 2 St James's Hospital and Trinity College, Dublin/Ireland, 3 Frontier Science Foundation-Hellas, Athens/Greece, 4 University Hospital Zurich, Zurich/Switzerland, 5 University Hospital Basel, Basel/Switzerland, 6 Maastricht University Medical Center, Maastricht/Netherlands, 7 Ospedale Clinicizzato, Chieti/Italy, 8 The Christie NHS Foundation Trust, Manchester/United Kingdom, 9 The Netherlands Cancer Institute, Amsterdam/Netherlands, 10 Aarhus University Hospital, Aarhus/Denmark, 11 Consorcio Hospital General Universitario de Valencia, Valencia/Spain, 12 Medical University Gdansk, Gdansk/Poland, 13 Roswell Park Cancer Institute, Buffalo, NY/United States of America, 14 Vall d'hebron University Hospital, Barcelona/Spain, 15 University Hospital KU Leuven, Leuven/Belgium, 16 Vall D'Hebron University Hospital, Barcelona/Spain, 17 Heidelberg University Hospital, Heidelberg/Germany, 18 The Netherlands Cancer Institute-Antoni Van Leeuwenhoek Hospital, Amsterdam/Netherlands, 19 Christie Hospital NHS Foundation Trust, Manchester/United Kingdom, 20 Medical University of Gdansk, Gdansk/Poland, 21 European Thoracic Oncology Platform, Bern/Switzerland, 22 Thermo Fisher Scientific, Paisley/United Kingdom, 23 Thermo Fisher Scientific, Austin, TX/United States of America, 24 Frontier Science Foundation-Hellas & University of Athens, Athens/Greece, 25 Aberdeen University Medical School, Aberdeen/United Kingdom, 26 VU University Medical Center, Amsterdam/Netherlands, 27 University Hospital Zurich, Zurich/Switzerland.

20 Thank you for your attention!

21 Thermo Fisher Scientific and its affiliates are not endorsing, recommending, or promoting any use or application of Thermo Fisher Scientific products presented by third parties during this seminar. Information and materials presented or provided by third parties are provided as-is and without warranty of any kind, including regarding intellectual property rights and reported results. Parties presenting images, text and material represent they have the rights to do so.

MET skipping mutation, EGFR

MET skipping mutation, EGFR New NSCLC biomarkers in clinical research: detection of MET skipping mutation, EGFR T790M, and other important biomarkers Fernando López-Ríos Laboratorio de Dianas Terapéuticas Hospital Universitario HM

More information

Solange Peters, MD-PhD Oncology Department Lausanne - CHUV BIOMARKERS IN CLINICAL TRIALS OF TARGETED TREATMENT MODALITIES

Solange Peters, MD-PhD Oncology Department Lausanne - CHUV BIOMARKERS IN CLINICAL TRIALS OF TARGETED TREATMENT MODALITIES Solange Peters, MD-PhD Oncology Department Lausanne - CHUV BIOMARKERS IN CLINICAL TRIALS OF TARGETED TREATMENT MODALITIES Prognostic and predictive factors Prognostic Provides information on outcome independent

More information

Molecular Testing in Lung Cancer

Molecular Testing in Lung Cancer Molecular Testing in Lung Cancer Pimpin Incharoen, M.D. Assistant Professor, Thoracic Pathology Department of Pathology, Ramathibodi Hospital Genetic alterations in lung cancer Source: Khono et al, Trans

More information

NGS in Lung Cancer Cytology

NGS in Lung Cancer Cytology Institute of Pathology NGS in Lung Cancer Cytology Spasenija Savic University Hospital Basel, Switzerland Disclosures Speakers honoraria and advisory boards: Astra Zeneca, BMS, MSD, Novartis, Pfizer, Roche

More information

Advances in Pathology and molecular biology of lung cancer. Lukas Bubendorf Pathologie

Advances in Pathology and molecular biology of lung cancer. Lukas Bubendorf Pathologie Advances in Pathology and molecular biology of lung cancer Lukas Bubendorf Pathologie Agenda The revolution of predictive markers Liquid biopsies PD-L1 Molecular subtypes (non-squamous NSCLC) Tsao AS et

More information

GENETIC TESTING FOR TARGETED THERAPY FOR NON-SMALL CELL LUNG CANCER (NSCLC)

GENETIC TESTING FOR TARGETED THERAPY FOR NON-SMALL CELL LUNG CANCER (NSCLC) CANCER (NSCLC) Non-Discrimination Statement and Multi-Language Interpreter Services information are located at the end of this document. Coverage for services, procedures, medical devices and drugs are

More information

Targeted therapy in non-small cell lung cancer: a focus on epidermal growth factor receptor mutations

Targeted therapy in non-small cell lung cancer: a focus on epidermal growth factor receptor mutations Review Article Page 1 of 5 Targeted therapy in non-small cell lung cancer: a focus on epidermal growth factor receptor mutations Gérard A. Milano Oncopharmacology Unit, EA 3836 UNS, Centre Antoine Lacassagne,

More information

Integration of Genomics Into Clinical Pathways. Precision Medicine and Decision Support

Integration of Genomics Into Clinical Pathways. Precision Medicine and Decision Support Integration of Genomics Into Clinical Pathways Precision Medicine and Decision Support Faculty Andrew Hertler, MD, FACP Chief Medical Officer New Century Health Andrew Hertler, MD, FACP is employed by

More information

LUNG CANCER. pathology & molecular biology. Izidor Kern University Clinic Golnik, Slovenia

LUNG CANCER. pathology & molecular biology. Izidor Kern University Clinic Golnik, Slovenia LUNG CANCER pathology & molecular biology Izidor Kern University Clinic Golnik, Slovenia 1 Pathology and epidemiology Small biopsy & cytology SCLC 14% NSCC NOS 4% 70% 60% 50% 63% 62% 61% 62% 59% 54% 51%

More information

Liquid biopsy: the experience of real life case studies

Liquid biopsy: the experience of real life case studies Liquid biopsy: the experience of real life case studies 10 th September 2018 Beatriz Bellosillo Servicio de Anatomía Patológica Hospital del Mar, Barcelona Agenda Introduction Experience in colorectal

More information

Do You Think Like the Experts? Refining the Management of Advanced NSCLC With ALK Rearrangement. Reference Slides Introduction

Do You Think Like the Experts? Refining the Management of Advanced NSCLC With ALK Rearrangement. Reference Slides Introduction Do You Think Like the Experts? Refining the Management of Advanced NSCLC With ALK Rearrangement Reference Slides Introduction EML4-ALK Fusion Oncogene Key Driver in 3% to 7% NSCLC Inversion or Translocation

More information

Updated Molecular Testing Guideline for the Selection of Lung Cancer Patients for Treatment with Targeted Tyrosine Kinase Inhibitors

Updated Molecular Testing Guideline for the Selection of Lung Cancer Patients for Treatment with Targeted Tyrosine Kinase Inhibitors Q: How is the strength of recommendation determined in the new molecular testing guideline? A: The strength of recommendation is determined by the strength of the available data (evidence). Strong Recommendation:

More information

Personalized Medicine: Lung Biopsy and Tumor

Personalized Medicine: Lung Biopsy and Tumor Personalized Medicine: Lung Biopsy and Tumor Mutation Testing Elizabeth H. Moore, MD Personalized Medicine: Lung Biopsy and Tumor Mutation Testing Genomic testing has resulted in a paradigm shift in the

More information

Joachim Aerts Erasmus MC Rotterdam, Netherlands. Drawing the map: molecular characterization of NSCLC

Joachim Aerts Erasmus MC Rotterdam, Netherlands. Drawing the map: molecular characterization of NSCLC Joachim Aerts Erasmus MC Rotterdam, Netherlands Drawing the map: molecular characterization of NSCLC Disclosures Honoraria for advisory board/consultancy/speakers fee Eli Lilly Roche Boehringer Ingelheim

More information

Rearrangement of the anaplastic lymphoma kinase (ALK)

Rearrangement of the anaplastic lymphoma kinase (ALK) Brief Report Clinical Implications of Variant ALK FISH Rearrangement Patterns Xin Gao, MD,* Lynette M. Sholl, MD,* Mizuki Nishino, MD,* Jennifer C. Heng, BS, Pasi A. Jänne, MD, PhD,* and Geoffrey R. Oxnard,

More information

DM Seminar. ALK gene rearrangements & ALK targeted therapy in NSCLC Dr Sarat

DM Seminar. ALK gene rearrangements & ALK targeted therapy in NSCLC Dr Sarat DM Seminar ALK gene rearrangements & ALK targeted therapy in NSCLC Dr Sarat Introduction Discovery of activating mutations in kinase domain of epidermal growth factor receptor (EGFR) opened a new era of

More information

NGS in Cancer Pathology After the Microscope: From Nucleic Acid to Interpretation

NGS in Cancer Pathology After the Microscope: From Nucleic Acid to Interpretation NGS in Cancer Pathology After the Microscope: From Nucleic Acid to Interpretation Michael R. Rossi, PhD, FACMG Assistant Professor Division of Cancer Biology, Department of Radiation Oncology Department

More information

The oncologist s point of view: the promise and challenges of increasing options for targeted therapies in NSCLC

The oncologist s point of view: the promise and challenges of increasing options for targeted therapies in NSCLC The oncologist s point of view: the promise and challenges of increasing options for targeted therapies in NSCLC Egbert F. Smit Department of Thoracic Oncology, Netherlands Cancer Institute, and Department

More information

Virtual Journal Club: Front-Line Therapy and Beyond Recent Perspectives on ALK-Positive Non-Small Cell Lung Cancer.

Virtual Journal Club: Front-Line Therapy and Beyond Recent Perspectives on ALK-Positive Non-Small Cell Lung Cancer. Virtual Journal Club: Front-Line Therapy and Beyond Recent Perspectives on ALK-Positive Non-Small Cell Lung Cancer Reference Slides ALK Rearrangement in NSCLC ALK (anaplastic lymphoma kinase) is a receptor

More information

SUBJECT: GENOTYPING - EPIDERMAL GROWTH

SUBJECT: GENOTYPING - EPIDERMAL GROWTH MEDICAL POLICY SUBJECT: GENOTYPING - EPIDERMAL GROWTH Clinical criteria used to make utilization review decisions are based on credible scientific evidence published in peer reviewed medical literature

More information

Lukas Bubendorf Pathologie. Liquid biopsies

Lukas Bubendorf Pathologie. Liquid biopsies Lukas Bubendorf Pathologie Liquid biopsies Liquid biopsies 1. Circulating cell-free tumor-dna (ctdna) 2. Circulating tumor cells (CTC) Source: Sysmex CTCs ctdna ctrna exosomes Quantification Protein RNA

More information

ALK Fusion Oncogenes in Lung Adenocarcinoma

ALK Fusion Oncogenes in Lung Adenocarcinoma ALK Fusion Oncogenes in Lung Adenocarcinoma Vincent A Miller, MD Associate Attending Physician, Thoracic Oncology Service Memorial Sloan-Kettering Cancer Center New York, New York The identification of

More information

TARGETED THERAPY FOR LUNG CANCER. Patient and Caregiver Guide

TARGETED THERAPY FOR LUNG CANCER. Patient and Caregiver Guide TARGETED THERAPY FOR LUNG CANCER Patient and Caregiver Guide TARGETED THERAPY FOR LUNG CANCER Patient and Caregiver Guide TABLE OF CONTENTS Why Targeted Therapy?...2 Lung Cancer Basics...2 Changes in

More information

The seventh edition of the tumor, node, metastasis (TNM)

The seventh edition of the tumor, node, metastasis (TNM) Original Article Lungscape: Resected Non Small-Cell Lung Cancer Outcome by Clinical and Pathological Parameters Solange Peters, MD, PhD,* Walter Weder, MD, Urania Dafni, ScD, Keith M. Kerr, PhD, Lukas

More information

Transform genomic data into real-life results

Transform genomic data into real-life results CLINICAL SUMMARY Transform genomic data into real-life results Biomarker testing and targeted therapies can drive improved outcomes in clinical practice New FDA-Approved Broad Companion Diagnostic for

More information

Corporate Medical Policy

Corporate Medical Policy Corporate Medical Policy Molecular Analysis for Targeted Therapy for Non-Small Cell Lung File Name: Origination: Last CAP Review: Next CAP Review: Last Review: molecular_analysis_for_targeted_therapy_for_non_small_cell_lung_cancer

More information

Predictive markers for treatment with Immune checkpoint inhibitors - PD-L1 et al -

Predictive markers for treatment with Immune checkpoint inhibitors - PD-L1 et al - Predictive markers for treatment with Immune checkpoint inhibitors - PD-L1 et al - Lukas Bubendorf Pathology Improved overall survival as a result of combination therapy Predictive biomarkers for the treatment

More information

Updated Molecular Testing Guideline for the Selection of Lung Cancer Patients for Treatment with Targeted Tyrosine Kinase Inhibitors

Updated Molecular Testing Guideline for the Selection of Lung Cancer Patients for Treatment with Targeted Tyrosine Kinase Inhibitors Updated Molecular Testing Guideline for the Selection of Lung Cancer Patients for Treatment with Targeted Tyrosine Kinase Inhibitors Guideline from the College of American Pathologists, the International

More information

UCL-Advanced Diagnostics. 2015/16 Service Update

UCL-Advanced Diagnostics. 2015/16 Service Update UCL-Advanced Diagnostics 2015/16 Service Update About UCL-Advanced Diagnostics UCL Advanced Diagnostics (UCL-AD) is the immunohistochemistry, in situ and molecular diagnostics service arm of the UCL-Cancer

More information

Biomarcatori per la immunoterapia: cosa e come cercare Paolo Graziano

Biomarcatori per la immunoterapia: cosa e come cercare Paolo Graziano Biomarcatori per la immunoterapia: cosa e come cercare Paolo Graziano Unit of Pathology Fondazione IRCCS Casa Sollievo della Sofferenza San Giovanni Rotondo, Foggia,Italy p.graziano@operapadrepio.it Disclosure

More information

Molecular Testing Updates. Karen Rasmussen, PhD, FACMG Clinical Molecular Genetics Spectrum Medical Group, Pathology Division Portland, Maine

Molecular Testing Updates. Karen Rasmussen, PhD, FACMG Clinical Molecular Genetics Spectrum Medical Group, Pathology Division Portland, Maine Molecular Testing Updates Karen Rasmussen, PhD, FACMG Clinical Molecular Genetics Spectrum Medical Group, Pathology Division Portland, Maine Keeping Up with Predictive Molecular Testing in Oncology: Technical

More information

When Policy Topic is covered Crizotinib may be considered medically necessary in patients 18 years or older when the following criteria are met:

When Policy Topic is covered Crizotinib may be considered medically necessary in patients 18 years or older when the following criteria are met: Xalkori (crizotinib) Policy Number: 5.01.539 Last Review: 6/2018 Origination: 7/2012 Next Review: 6/2019 Policy Blue Cross and Blue Shield of Kansas City (Blue KC) will provide coverage for crizotinib

More information

Molecular Targets in Lung Cancer

Molecular Targets in Lung Cancer Molecular Targets in Lung Cancer Robert Ramirez, DO, FACP Thoracic and Neuroendocrine Oncology November 18 th, 2016 Disclosures Consulting and speaker fees for Ipsen Pharmaceuticals, AstraZeneca and Merck

More information

Tumor Agnostic Therapies and Clinical Trial Design

Tumor Agnostic Therapies and Clinical Trial Design Disclosures Tumor Agnostic Therapies and Clinical Trial Design Current employment: Xcenda Megan Pollack, PharmD, BCOP, BCPS Xcenda Assistant Director, Oncology Medical Communications Objectives Recognize

More information

Overview of the ESP Lung and Colon EQA schemes with a focus on Dutch laboratories

Overview of the ESP Lung and Colon EQA schemes with a focus on Dutch laboratories Overview of the ESP Lung and Colon EQA schemes with a focus on Dutch laboratories Dr. Nils t Hart University Medical Center Groningen, The Netherlands Drs. Cleo Keppens Catholic University of Leuven, Belgium

More information

Beyond ALK and EGFR: Novel molecularly driven targeted therapies in NSCLC Federico Cappuzzo AUSL della Romagna, Ravenna, Italy

Beyond ALK and EGFR: Novel molecularly driven targeted therapies in NSCLC Federico Cappuzzo AUSL della Romagna, Ravenna, Italy Beyond ALK and EGFR: Novel molecularly driven targeted therapies in NSCLC Federico Cappuzzo AUSL della Romagna, Ravenna, Italy Oncogenic drivers in NSCLC Certain tumours arise as a result of aberrant activation

More information

MP Circulating Tumor DNA Management of Non-Small-Cell Lung Cancer (Liquid Biopsy)

MP Circulating Tumor DNA Management of Non-Small-Cell Lung Cancer (Liquid Biopsy) Medical Policy BCBSA Ref. Policy: 2.04.143 Last Review: 10/18/2018 Effective Date: 10/18/2018 Section: Medicine Related Policies 2.04.121 Miscellaneous Genetic and Molecular Diagnostic Tests 2.04.45 Molecular

More information

Tumor mutational burden and its transition towards the clinic

Tumor mutational burden and its transition towards the clinic Tumor mutational burden and its transition towards the clinic G C C A T C A C Wolfram Jochum Institute of Pathology Kantonsspital St.Gallen CH-9007 St.Gallen wolfram.jochum@kssg.ch 30th European Congress

More information

Plotting the course: optimizing treatment strategies in patients with advanced adenocarcinoma

Plotting the course: optimizing treatment strategies in patients with advanced adenocarcinoma Pieter E. Postmus University of Liverpool Liverpool, UK Plotting the course: optimizing treatment strategies in patients with advanced adenocarcinoma Disclosures Advisor Bristol-Myers Squibb AstraZeneca

More information

http://www.eortc.org/carefor/ Brussels, October 14 2015 Which organizations do clinical research? Pharmaceutical industry [in vitro]medical device industry Academic sponsors Universities & hospitals Networks

More information

Circulating Tumor DNA for Management of Non-Small-Cell Lung Cancer (Liquid Biopsy)

Circulating Tumor DNA for Management of Non-Small-Cell Lung Cancer (Liquid Biopsy) Circulating Tumor DNA for Management of Non-Small-Cell Lung Cancer (Liquid Biopsy) Policy Number: 2.04.143 Last Review: 1/2019 Origination: 1/2018 Next Review: 1/2020 Policy Blue Cross and Blue Shield

More information

Improving outcomes for NSCLC patients with brain metastases

Improving outcomes for NSCLC patients with brain metastases Improving outcomes for NSCLC patients with brain metastases Martin Schuler West German Cancer Center, Essen, Germany In Switzerland, afatinib is approved as monotherapy for patients with non-small cell

More information

Personalised Healthcare (PHC) with Foundation Medicine (FMI) Fatma Elçin KINIKLI, FMI Turkey, Science Leader

Personalised Healthcare (PHC) with Foundation Medicine (FMI) Fatma Elçin KINIKLI, FMI Turkey, Science Leader Personalised Healthcare (PHC) with Foundation Medicine (FMI) Fatma Elçin KINIKLI, FMI Turkey, Science Leader Agenda PHC Approach Provides Better Patient Outcome FMI offers Comprehensive Genomic Profiling,

More information

Studying First Line Treatment of Chronic Myeloid Leukemia (CML) in a Real-world Setting (SIMPLICITY)

Studying First Line Treatment of Chronic Myeloid Leukemia (CML) in a Real-world Setting (SIMPLICITY) A service of the U.S. National Institutes of Health Studying First Line Treatment of Chronic Myeloid Leukemia (CML) in a Real-world Setting (SIMPLICITY) This study is currently recruiting participants.

More information

VENTANA ALK (D5F3) Rabbit Monoclonal Primary Antibody. ALK IHC Biomarker Testing Aiding in patient diagnosis

VENTANA ALK (D5F3) Rabbit Monoclonal Primary Antibody. ALK IHC Biomarker Testing Aiding in patient diagnosis VENTANA (D5F3) Rabbit Monoclonal Primary Antibody IHC Biomarker Testing Aiding in patient diagnosis 2 IHC Biomarker Testing Lung cancer is the leading cause of death Lung cancer is the most prevalent form

More information

Product Introduction

Product Introduction Product Introduction Product Codes: HCL026, HCL027 and HCL028 Contents Introduction to HER2 2 HER2 immunohistochemistry 3 Cell lines as controls 5 HER2 Analyte Control DR IHC 7 HER2 Analyte Control DR

More information

CDx in oncology Prof. Christophe Le Tourneau, MD, PhD FEAM Geneva September 27, 2018

CDx in oncology Prof. Christophe Le Tourneau, MD, PhD FEAM Geneva September 27, 2018 CDx in oncology Prof. Christophe Le Tourneau, MD, PhD Institut Curie Paris & Saint-Cloud France Head, Department of Drug Development and Innovation (D 3 i) INSERM U900 Research unit Versailles Saint-Quentin-en-Yvelines

More information

Next generation diagnostics Bringing high-throughput sequencing into clinical application

Next generation diagnostics Bringing high-throughput sequencing into clinical application Next generation diagnostics Bringing high-throughput sequencing into clinical application Leonardo A. Meza-Zepeda, PhD Translational Genomics Group Institute for Cancer Research Leonardo.Meza-Zepeda@rr-research.no

More information

ALK Rearrangements in NSCLC Detection and Issues in Modern Pathology. 3rd ITOCD Dresden September 13, 2012

ALK Rearrangements in NSCLC Detection and Issues in Modern Pathology. 3rd ITOCD Dresden September 13, 2012 ALK Rearrangements in NSCLC Detection and Issues in Modern Pathology 3rd ITOCD Dresden September 13, 2012 Agenda The Importance of Targeted Therapies in NSCLC (Prof. Kenneth O Byrne, Thoracic Oncology

More information

Personalized Genetics

Personalized Genetics Personalized Genetics Understanding Your Genetic Test Results Tracey Evans, MD September 29, 2017 Genetics 101 Punnett Square Genetic Pedigree 2 Genetics 101 Punnett Square Genetic Pedigree 3 It s not

More information

Original Articles. Implications for Optimal Clinical Testing

Original Articles. Implications for Optimal Clinical Testing Original Articles Comparison of Reverse Transcription-Polymerase Chain Reaction, Immunohistochemistry, and Fluorescence In Situ Hybridization Methodologies for Detection of Echinoderm Microtubule-Associated

More information

CLINICAL MEDICAL POLICY

CLINICAL MEDICAL POLICY Policy Name: Policy Number: Responsible Department(s): CLINICAL MEDICAL POLICY Molecular Tumor Markers for Non-Small Cell Lung Cancer (NSCLC) MP-061-MD-DE Medical Management Provider Notice Date: 10/15/2018;

More information

Identification of Novel Variant of EML4-ALK Fusion Gene in NSCLC: Potential Benefits of the RT-PCR Method

Identification of Novel Variant of EML4-ALK Fusion Gene in NSCLC: Potential Benefits of the RT-PCR Method International journal of Biomedical science ORIGINAL ARTICLE Identification of Novel Variant of EML4-ALK Fusion Gene in NSCLC: Potential Benefits of the RT-PCR Method Martin K. H. Maus 1, 2, Craig Stephens

More information

Next-generation sequencing based clinical testing for lung cancer in Japan

Next-generation sequencing based clinical testing for lung cancer in Japan Review Article Next-generation sequencing based clinical testing for lung cancer in Japan Masayuki Takeda 1, Kazuko Sakai 2, Kazuhiko Nakagawa 1, Kazuto Nishio 2 1 Department of Medical Oncology, 2 Department

More information

Evolution of Pathology

Evolution of Pathology 1 Traditional pathology Molecular pathology 2 Evolution of Pathology Gross Pathology Cellular Pathology Morphologic Pathology Molecular/Predictive Pathology Antonio Benivieni (1443-1502): First autopsy

More information

Medical Policy An independent licensee of the Blue Cross Blue Shield Association

Medical Policy An independent licensee of the Blue Cross Blue Shield Association Circulating Tumor DNA Management of Non-Small-Cell Lung Cancer (Liquid Biopsy) Page 1 of 36 Medical Policy An independent licensee of the Blue Cross Blue Shield Association Title: Circulating Tumor DNA

More information

Other Driver Mutations: cmet, B-RAF, RET, NTRK

Other Driver Mutations: cmet, B-RAF, RET, NTRK Other Driver Mutations: cmet, B-RAF, RET, NTRK Luis E. Raez MD FACP FCCP Chief of Hematology/Oncology and Medical Director, Memorial Cancer Institute Clinical Professor of Medicine Herbert Wertheim College

More information

A case of different EGFR mutations in surgically resected synchronous triple lung cancer

A case of different EGFR mutations in surgically resected synchronous triple lung cancer Case Report A case of different EGFR mutations in surgically resected synchronous triple lung cancer Naoki Haratake 1, Mitsuhiro Takenoyama 1, Makoto Edagawa 1, Shinichiro Shimamatsu 1, Ryo Toyozawa 1,

More information

Strengths and Weaknesses of PD-L1 testing: Pathology perspective

Strengths and Weaknesses of PD-L1 testing: Pathology perspective Strengths and Weaknesses of PD-L1 testing: Pathology perspective Prof Keith M Kerr Department of Pathology Aberdeen University Medical School, Aberdeen Royal Infirmary Foresterhill, Aberdeen Disclosures

More information

QIAGEN Complete Solutions for Liquid Biopsy Molecular Testing

QIAGEN Complete Solutions for Liquid Biopsy Molecular Testing QIAGEN Complete Solutions for Liquid Biopsy Molecular Testing Christopher Swagell, PhD Market Development Manager, Advanced Molecular Pathology QIAGEN 1 Agenda QIAGEN Solid Tumor Testing and Liquid Biopsy

More information

Disclosures Genomic testing in lung cancer

Disclosures Genomic testing in lung cancer Disclosures Genomic testing in lung cancer No disclosures Objectives Understand how FISH and NGS provide complementary data for the evaluation of lung cancer Recognize the challenges of performing testing

More information

Association of molecular status and organs with metastases at diagnosis in patients with non-small cell lung cancer (NSCLC)

Association of molecular status and organs with metastases at diagnosis in patients with non-small cell lung cancer (NSCLC) Association of molecular status and organs with metastases at diagnosis in patients with non-small cell lung cancer (NSCLC) Chantal Kuijpers* 1,2, Lizza Hendriks 3, Jules Derks 3, Anne-Marie Dingemans

More information

7/6/2015. Cancer Related Deaths: United States. Management of NSCLC TODAY. Emerging mutations as predictive biomarkers in lung cancer: Overview

7/6/2015. Cancer Related Deaths: United States. Management of NSCLC TODAY. Emerging mutations as predictive biomarkers in lung cancer: Overview Emerging mutations as predictive biomarkers in lung cancer: Overview Kirtee Raparia, MD Assistant Professor of Pathology Cancer Related Deaths: United States Men Lung and bronchus 28% Prostate 10% Colon

More information

8/22/2016. Major risk factors for the development of lung cancer are: Outline

8/22/2016. Major risk factors for the development of lung cancer are: Outline Carcinomas of the Lung: Changes in Staging, Adenocarcinoma Classification and Genetics Grace Y. Lin, M.D., Ph.D. Outline Background Staging of Lung Cancer: Review of the 2010 7 th Edition of the AJCC Cancer

More information

2/3/2015. The Pathologist and the Healthcare System: Refining and Redefining Our Role

2/3/2015. The Pathologist and the Healthcare System: Refining and Redefining Our Role The Pathologist and the Healthcare System: Refining and Redefining Our Role Jennifer L. Hunt, MD, MEd Aubrey J. Hough Jr, MD, Endowed Professor of Pathology Chair of Pathology and Laboratory Medicine University

More information

Molecular Diagnosis of Lung Cancer

Molecular Diagnosis of Lung Cancer Molecular Diagnosis of Lung Cancer Lucian R. Chirieac, M.D. Assistant Professor of Pathology Harvard Medical School Staff Pathologist, Department of Pathology Brigham and Women's Hospital 75 Francis Street

More information

Refining Prognosis of Early Stage Lung Cancer by Molecular Features (Part 2): Early Steps in Molecularly Defined Prognosis

Refining Prognosis of Early Stage Lung Cancer by Molecular Features (Part 2): Early Steps in Molecularly Defined Prognosis 5/17/13 Refining Prognosis of Early Stage Lung Cancer by Molecular Features (Part 2): Early Steps in Molecularly Defined Prognosis Johannes Kratz, MD Post-doctoral Fellow, Thoracic Oncology Laboratory

More information

PD-L1 Analyte Control DR

PD-L1 Analyte Control DR Quality in Control PD-L1 Analyte Control DR PD-L1_PI_v2 Product Codes: HCL019, HCL020 and HCL021 Contents PD-L1 Analyte Control DR 2 What is PD-L1? 3 The Role of PD-L1 in Cancer 3 PD-L1 Assessment 4 PD-L1

More information

NCCN Non Small Cell Lung Cancer V Meeting July 8, 2016

NCCN Non Small Cell Lung Cancer V Meeting July 8, 2016 NSCL 3 Submission from Myriad requesting the following statement to be listed as an additional high risk factor in footnote p : For lung ADC, a highrisk 46 gene molecular prognostic score determined by

More information

Matthew Smolkin, MD HCLD Medical Director Molecular Pathology Diagnostic Laboratory

Matthew Smolkin, MD HCLD Medical Director Molecular Pathology Diagnostic Laboratory Molecular Profiling Matthew Smolkin, MD HCLD Medical Director Molecular Pathology Diagnostic Laboratory Objectives Defining molecular profiling Technologies Why do we profile tumors? Current testing &

More information

NGS IN ONCOLOGY: FDA S PERSPECTIVE

NGS IN ONCOLOGY: FDA S PERSPECTIVE NGS IN ONCOLOGY: FDA S PERSPECTIVE ASQ Biomed/Biotech SIG Event April 26, 2018 Gaithersburg, MD You Li, Ph.D. Division of Molecular Genetics and Pathology Food and Drug Administration (FDA) Center for

More information

ECMC cfdna consensus meeting

ECMC cfdna consensus meeting ECMC cfdna consensus meeting State of the art for cfdna technologies 24 th November 2014 Applications of ctdna analysis for drug development Potential of ctdna analysis to: Identify the right patients

More information

The human kinome consists of more than 500 structurally

The human kinome consists of more than 500 structurally ORIGINAL ARTICLE Preclinical Rationale for Use of the Clinically Available Multitargeted Tyrosine Kinase Inhibitor Crizotinib in ROS1 -Translocated Lung Cancer Hiroyuki Yasuda, MD, Lorena L. de Figueiredo-Pontes,

More information

Next-Generation Sequencing: Targeting Targeted Therapies. Justine N. McCutcheon and Giuseppe Giaccone

Next-Generation Sequencing: Targeting Targeted Therapies. Justine N. McCutcheon and Giuseppe Giaccone Next-Generation Sequencing: Targeting Targeted Therapies Justine N. McCutcheon and Giuseppe Giaccone Lombardi Comprehensive Cancer Center, Georgetown University, Washington, DC Corresponding Author: Giuseppe

More information

[(Lung Cancer Therapy Annual 7)] [Author: Rolf A. Stahel] Published On (August, 2012) By Rolf A. Stahel READ ONLINE

[(Lung Cancer Therapy Annual 7)] [Author: Rolf A. Stahel] Published On (August, 2012) By Rolf A. Stahel READ ONLINE [(Lung Cancer Therapy Annual 7)] [Author: Rolf A. Stahel] Published On (August, 2012) By Rolf A. Stahel READ ONLINE If searching for a ebook [(Lung Cancer Therapy Annual 7)] [Author: Rolf A. Stahel] published

More information

Molecular Testing Guideline for Selection of Lung Cancer Patients for EGFR and ALK Tyrosine Kinase Inhibitors

Molecular Testing Guideline for Selection of Lung Cancer Patients for EGFR and ALK Tyrosine Kinase Inhibitors SPECIAL Article Molecular Testing Guideline for Selection of Lung Cancer Patients for EGFR and ALK Tyrosine Kinase Inhibitors Guideline from the College of American Pathologists, International Association

More information

Positive response to Icotinib in metastatic lung adenocarcinoma with acquiring EGFR Leu792H mutation after AZD9291 treatment: a case report

Positive response to Icotinib in metastatic lung adenocarcinoma with acquiring EGFR Leu792H mutation after AZD9291 treatment: a case report Wang and Chen BMC Cancer (2019) 19:131 https://doi.org/10.1186/s12885-019-5352-7 CASE REPORT Open Access Positive response to Icotinib in metastatic lung adenocarcinoma with acquiring EGFR Leu792H mutation

More information

How could molecular profiling impact histology independent labels in the future?

How could molecular profiling impact histology independent labels in the future? How could molecular profiling impact histology independent labels in the future? Marlene Thomas Senior international scientific director for personalised healthcare F. Hoffman-La Roche Ltd The information

More information

Personalized cancer therapy has attracted much attention

Personalized cancer therapy has attracted much attention ORIGINAL ARTICLE EML4-ALK Translocation Predicts Better Outcome in Lung Adenocarcinoma Patients with Wild-Type EGFR Shang-Gin Wu, MD,* Yao-Wen Kuo, MD,* Yih-Leong Chang, MD, Jin-Yuan Shih, MD, PhD, Ya-Hui

More information

Targeted therapies for advanced non-small cell lung cancer. Tom Stinchcombe Duke Cancer Insitute

Targeted therapies for advanced non-small cell lung cancer. Tom Stinchcombe Duke Cancer Insitute Targeted therapies for advanced non-small cell lung cancer Tom Stinchcombe Duke Cancer Insitute Topics ALK rearranged NSCLC ROS1 rearranged NSCLC EGFR mutation: exon 19/exon 21 L858R and uncommon mutations

More information

Quality in Control. ROS1 Analyte Control. Product Codes: HCL022, HCL023 and HCL024

Quality in Control. ROS1 Analyte Control. Product Codes: HCL022, HCL023 and HCL024 Quality in Control ROS1 Analyte Control Product Codes: HCL022, HCL023 and HCL024 Contents What is ROS1? 2 The Role of ROS1 in Cancer 3 ROS1 Assessment 3 ROS1 Analyte Control Product Details 4 ROS1 Analyte

More information

Quan Zhang, Na Qin, Jinghui Wang, Jialin Lv, Xinjie Yang, Xi Li, Jingying Nong, Hui Zhang, Xinyong Zhang, Yuhua Wu & Shucai Zhang

Quan Zhang, Na Qin, Jinghui Wang, Jialin Lv, Xinjie Yang, Xi Li, Jingying Nong, Hui Zhang, Xinyong Zhang, Yuhua Wu & Shucai Zhang Thoracic Cancer ISSN 1759-7706 ORIGINAL ARTICLE Crizotinib versus platinum-based double-agent chemotherapy as the first line treatment in advanced anaplastic lymphoma kinase-positive lung adenocarcinoma

More information

Role of the pathologist in the diagnosis and mutational analysis of lung cancer Professor J R Gosney

Role of the pathologist in the diagnosis and mutational analysis of lung cancer Professor J R Gosney Role of the pathologist in the diagnosis and mutational analysis of lung cancer Professor J R Gosney Consultant Thoracic Pathologist Royal Liverpool University Hospital Disclosure JRG is a paid advisor

More information

NGS ONCOPANELS: FDA S PERSPECTIVE

NGS ONCOPANELS: FDA S PERSPECTIVE NGS ONCOPANELS: FDA S PERSPECTIVE CBA Workshop: Biomarker and Application in Drug Development August 11, 2018 Rockville, MD You Li, Ph.D. Division of Molecular Genetics and Pathology Food and Drug Administration

More information

Biomedical Research 2017; 28 (14): ISSN X

Biomedical Research 2017; 28 (14): ISSN X Biomedical Research 2017; 28 (14): ISSN 0970-938X www.biomedres.info Study of the relationship between EGFR mutation status and bone metastasis in advanced lung adenocarcinoma. Xiaoye Ai, Adalati Yasheng,

More information

Identifying ALK+ NSCLC patients for targeted treatment

Identifying ALK+ NSCLC patients for targeted treatment VENTANA (D5F3) CDx Assay Identifying + NSCLC patients for targeted treatment VENTANA (D5F3) CDx Assay Identify + NSCLC patients eligible for treatment with XORI, ZYKADIA or ALECENSA NSCLC tissue samples

More information

2015 EUROPEAN CANCER CONGRESS

2015 EUROPEAN CANCER CONGRESS 2015 EUROPEAN CANCER CONGRESS 25-29 September 2015 Vienna, Austria SUMMARY The European Cancer Congress (ECC 2015) combined the 40th European Society for Medical Oncology (ESMO) congress with the 18th

More information

MICROSCOPY PREDICTIVE PROFILING

MICROSCOPY PREDICTIVE PROFILING Immunomodulatory therapy in NSCLC: a year into clinical practice Professor J R Gosney Consultant Thoracic Pathologist Royal Liverpool University Hospital Disclosure JRG is a paid advisor to and speaker

More information

Select analysis on the next pages. Sample request and sending address see last page. Institut für Pathologie und Molekularpathologie

Select analysis on the next pages. Sample request and sending address see last page. Institut für Pathologie und Molekularpathologie Diagnostic Tumor Genome Analysis Schmelzbergstrasse 12 8091 Zürich Tel.: (+41) 044 255 3929 Fax.: (+41) 044 255 4416 Client (address, telephone number): ngs.pathologie@usz.ch www.pathologie.usz.ch Sample-Nr:

More information

Anaplastic lymphoma kinase tyrosine kinase inhibitors in non-small cell lung cancer

Anaplastic lymphoma kinase tyrosine kinase inhibitors in non-small cell lung cancer Review Article Anaplastic lymphoma kinase tyrosine kinase inhibitors in non-small cell lung cancer Tiziana Vavalà 1, Annapaola Mariniello 2, Silvia Novello 2 1 SC of Oncology, ASL CN1, Ospedale Civile

More information

Detection of Anaplastic Lymphoma Kinase (ALK) gene in Non-Small Cell lung Cancer (NSCLC) By CISH Technique

Detection of Anaplastic Lymphoma Kinase (ALK) gene in Non-Small Cell lung Cancer (NSCLC) By CISH Technique Cancer and Clinical Oncology; Vol. 7, No. 1; 2018 ISSN 1927-4858 E-ISSN 1927-4866 Published by Canadian Center of Science and Education Detection of Anaplastic Lymphoma Kinase (ALK) gene in Non-Small Cell

More information

D Ross Camidge, MD, PhD

D Ross Camidge, MD, PhD i n t e r v i e w D Ross Camidge, MD, PhD Dr Camidge is Director of the Thoracic Oncology Clinical Program and Associate Director for Clinical Research at the University of Colorado Cancer Center in Aurora,

More information

Quality in Control ALK-Lung Analyte Control (EML4-ALK) ALK-Lymphoma Analyte Control (NPM-ALK)

Quality in Control ALK-Lung Analyte Control (EML4-ALK) ALK-Lymphoma Analyte Control (NPM-ALK) Quality in Control ALK-Lung Analyte Control (EML4-ALK) ALK-Lymphoma Analyte Control (NPM-ALK) 10 Product Codes: HCL007, HCL008 and HCL009 HCL010, HCL011 and HCL012 Page 1 of Contents 1. What is ALK?...

More information

Carcinoma Urotelial: La Célula Inflamatoria Clave en la Inmunoterapia Fernando López-Ríos

Carcinoma Urotelial: La Célula Inflamatoria Clave en la Inmunoterapia Fernando López-Ríos Carcinoma Urotelial: La Célula Inflamatoria Clave en la Inmunoterapia Fernando López-Ríos Laboratorio de Dianas Terapéuticas Hospital Universitario HM Sanchinarro Madrid, Spain Contents Background Immunotherapy

More information

1. Q: What has changed from the draft recommendations posted for public comment in November/December 2011?

1. Q: What has changed from the draft recommendations posted for public comment in November/December 2011? Frequently Asked Questions (FAQs) in regard to Molecular Testing Guideline for Selection of Lung Cancer Patients for EGFR and ALK Tyrosine Kinase Inhibitors 1. Q: What has changed from the draft recommendations

More information

Medical Policy. MP Molecular Analysis for Targeted Therapy of Non-Small-Cell Lung Cancer

Medical Policy. MP Molecular Analysis for Targeted Therapy of Non-Small-Cell Lung Cancer Medical Policy MP 2.04.45 BCBSA Ref. Policy: 2.04.45 Last Review: 10/30/2017 Effective Date: 10/30/2017 Section: Medicine Related Policies 2.04.115 Molecular Panel Testing of Cancers to Identify Targeted

More information

Qué hemos aprendido hasta hoy? What have we learned so far?

Qué hemos aprendido hasta hoy? What have we learned so far? Qué hemos aprendido hasta hoy? What have we learned so far? Luís Costa Hospital de Santa Maria & Instituto de Medicina Molecular Faculdade de Medicina de Lisboa Disclosures Research Grants: Amgen; Novartis;

More information

Lung Cancer Genetics: Common Mutations and How to Treat Them David J. Kwiatkowski, MD, PhD. Mount Carrigain 2/4/17

Lung Cancer Genetics: Common Mutations and How to Treat Them David J. Kwiatkowski, MD, PhD. Mount Carrigain 2/4/17 Lung Cancer Genetics: Common Mutations and How to Treat Them David J. Kwiatkowski, MD, PhD Mount Carrigain 2/4/17 Histology Adenocarcinoma: Mixed subtype, acinar, papillary, solid, micropapillary, lepidic

More information

Implementation of nation-wide molecular testing in oncology in the French Health care system : quality assurance issues & challenges

Implementation of nation-wide molecular testing in oncology in the French Health care system : quality assurance issues & challenges Implementation of nation-wide molecular testing in oncology in the French Health care system : quality assurance issues & challenges Frédérique Nowak - 21 october 2015 "Putting Science into Standards event:

More information

Fusion Analysis of Solid Tumors Reveals Novel Rearrangements in Breast Carcinomas

Fusion Analysis of Solid Tumors Reveals Novel Rearrangements in Breast Carcinomas Fusion Analysis of Solid Tumors Reveals Novel Rearrangements in Breast Carcinomas Igor Astsaturov Philip Ellis Jeff Swensen Zoran Gatalica David Arguello Sandeep Reddy Wafik El-Deiry Disclaimers Dr. Igor

More information