Strength of the Data Regarding Nutrition and Cancer

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1 1. Nutrition and Cancer 2. Strength of the Data Regarding Nutrition and Cancer Page - 1

2 3. Major Source of the DATA 4. Nutrition and Cancer Page - 2

3 5. Diets high in what dietary factors 6. Diets low in what dietary factors Page - 3

4 7. Foods and Risk of Cancer 8. Foods and Risk of Cancer Page - 4

5 9. Learning Objectives 10. Leading Causes of Death in US (1998) Page - 5

6 11. Cancer Mortality, 2002 (Females) 12. Cancer Mortality, 2002 (Males) Page - 6

7 13. Estimated Causes of Cancer in US, Causes of Cancer Page - 7

8 15. Cross-country Comparisons 16. Cancer: Definition Page - 8

9 17. Cancer Cells Themes: Role of Nutrition Page - 9

10 19. Nutrition and Cancer 20. Two Stages in Cancer Development Page - 10

11 21. Cancer Formation and Nutrition 22. Examples of ROS Page - 11

12 23. Theme 1: Antioxidants as Protectors of Initiation 24. Theme 1: Antioxidants as Protectors Against Initiation Page - 12

13 25. Cancer and Antioxidant Protection 26. Theme 2: Fat Intake as a Promoter of Cancer Page - 13

14 27. Theme 2: Fat Intake as a Promoter of Cancer 28. : Slide 28 Page - 14

15 29. Breast Cancer Incidence Rates in Migrant Pops. 30. Risk Factors for Breast Cancer Page - 15

16 31. Theme 2: Fat Intake 32. Case-Control Studies in Breast Cancer Page - 16

17 33. Dietary Fat and Breast Cancer (Nurse's Study) 34. Dietary Fat and Breast Cancer (Nurse s Study) Page - 17

18 35. Comparison of Estradiol Levels in British and Chinese Women Diet Intervention Study (N=55 pre-menopausal women) Page - 18

19 37. Nutrition Intervention Studies of Low Fat/High Fiber 38. Nutrition Intervention Trial: Women s Health Initiativ... Page - 19

20 39. Colon Cancer and Fat Intake: Promoter 40. Colon Cancer and Fat Intake Page - 20

21 41. Age-Adjusted Relative Risk of Colon Cancer 42. Intervention Studies in Colorectal Cancer (Fat and Fiber)... Page - 21

22 43. Intervention Trials on Fiber in Colorectal Cancer 44. Intervention Trials on Fiber in Colon Rectal Cancer Page - 22

23 45. Theme 3: Fiber Intake as an Anti-promoter 46. Quote Page - 23

24 47. Relative Risk of Colorectal Cancer 48. Relative Risk of Colorectal Cancer Page - 24

25 49. Theme 4: Differentiation and Vitamin A 50. Theme 4: Vitamin A and Differentiation Page - 25

26 51. Theme 4: Vitamin A and Differentiation 52. Theme 5: Phytochemicals Page - 26

27 53. Theme 5: Phytochemicals 54. : Slide 54 Page - 27

28 55. Theme 5: Phytochemicals Functions of Phytochemicals are Dive Theme 5: Phytochemicals Function of Phytochemicals, cont... Page - 28

29 57. : Slide : Slide 58 Page - 29

30 59. : Slide : Slide 60 Page - 30

31 61. Principles 62. Theme 5: Phytochemicals Page - 31

32 63. Summary: 5 Themes 64. Types of Studies on Nutrition and Cancer Page - 32

33 65. Challenges in Diet and Cancer 66. Bradford-Hill Criteria Page - 33

34 67. Cancers with the Strongest Links to Nutritional Factors 68. Current Dietary Recommendations to Decrease Risk of Cancer... Page - 34

35 69. Nutrition and Cancer Summary 70. Nutrigenomics Page - 35

36 71. Interaction Between Nutrition and the Human Genome 72. Direct and Indirect Effects of Nutrients on Gene Expression... Page - 36

37 73. Example: Type of Fat (n-3 fatty acids) 74. Concept Page - 37

38 75. Special Role of n-3 Fatty Acids Page - 38

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