Republican Research and Practical Center for Radiation Medicine and Human Ecology. Ilya Veyalkin Head of Laboratory of Epidemiology Gomel, Belarus

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1 Republican Research and Practical Center for Radiation Medicine and Human Ecology Ilya Veyalkin Head of Laboratory of Epidemiology Gomel, Belarus

2 The contaminated area in the Republic of Belarus consisted of 3600 settlements (including 27 cities), where 2.2 million people lived. Currently, there live about 1.5 million people related to the affected population.

3 Radiation affected population monitoring; Obtaining the reliable data on the medical and biological effects of the Chernobyl accident; Provision of information to support dispensary examination, planning and carrying out therapeutic measures.

4 Maintenance of a personalized automated records of persons affected by the accident; Dynamic replenishment of necessary information about the persons affected by the accident; Development of normative-legal acts for the medical monitoring of the various categories of the affected citizens.

5 1 GPR - persons who participated in the liquidation of the Chernobyl accident and its consequences, divided into two subgroups 2 GPR persons evacuated or who left the areas of evacuation on their own in 1986; 3 GPR people living or working in the areas of primary and subsequent resettlement, as well as those who were resettled or who left these areas after the accident on their own; 4 GPR - persons born from people of 1-3groups, except for children belonging to the 2 and 3 groups; 5 GPR - people living or working in areas with the right of resettlement and of periodic radiation monitoring, as well as residents of other settlements, where the average equivalent radiation dose exceeds 1 msv per year. 6 GPR - persons who participated in the liquidation or affected by the accidents and their consequences at other nuclear facilities of civil or military purposes, as well as the victims of these accidents or as a result of trials, tests or other work related to nuclear facilities, including nuclear weapons; 7 GPR disabled people due to the Chernobyl NPP accident from the number of people who have no status affected due to the Chernobyl NPP accident, as well as children and adolescents upon detection of diseases of blood-forming organs (acute leukemia), thyroid gland (adenoma, cancer) and malignant tumors if they are not assigned to other groups of primary accounting.

6 GPR Total number UnderObservation at Number of Cancer Cases ( ) 1GPR (Liquidators) GPR (Evacuees) GPR (Residents) GPR (Offspring)

7 Total Children

8 Minsk Region Grodno Region Minsk city [ПРОЦЕНТ] Mogilev Region [ПРОЦЕНТ] [ПРОЦЕНТ] [ПРОЦЕНТ] Brest Region [ПРОЦЕНТ] Gomel Region [ПРОЦЕНТ]

9 n Residents Liquidators Offspring Evacuees

10 Median of Age, years Liquidators Evacuees Residents Offspring

11 Per Birth Rate Mortality Rate Birth Rate Belarus Mortality Rate Belarus

12 Per (World standard) Belarus Liquidators Evacuees Residents

13 Affected Belarus 6.9% 8.0% 59.5% 8% 10% 56% 9.4% 12% 16.1% Cardiovascular diseases 14% Neoplasm Symptoms, signs and abnormal clinical and laboratory findings, not elsewhere classified Injury, poisoning and certain other consequences of external causes

14 Affected Diseases of the respiratory system Belarus 9.1% 26.9 % 49.8 % Cardiovascular diseases 10% 25% Diseases of the musculoskeletal system and connective tissue 52% 4.0% 5.9% 4.2% Diseases of the skin and subcutaneous tissue 5% 5% 3% Injury, poisoning and certain other consequences of external causes Other

15 From 1986 to 2014 the number of registered cases of cancer in Belarus increased from to (2 times)

16 In general there were many speculations, assumptions and predictions about the role of Chernobyl accident in cancer growth in Belarus. Most assumptions have been varying with the time. And till the present the question about role of Chernobyl accident has not been answered. But the growth of Thyroid cancer has been evident.

17 From 1978 to 2014 the number of registered cases of cancer in Belarus increased from to GR=3,4% a year GR=3,3% a year

18 Rate per population Rate per population Stomach (males) Stomach (females) Lip (males) The left scale is for incidence rates of stomach cancer (males, females). The right scale is for incidence rates of lip cancer. Years

19 Rate per population Lip (females) 4.00 Esophageas (females) Larynx (females) 3.00 Lung (females) 2.00 Pancreatic (females) 1.00 Liver (females) Urinary bladder (females) 0.00 Years

20 Rate per population Colon (males) Colon (females) Melanoma (males) Melanoma (females) Rate per population Corpus uteri Kidney (females) Breast The right scale is for incidence rates of breast cancer. The left scale is for all presented sites Years

21 Rate per population Esophageas (males) Rectal (males) Pancreatic (males) Rate per population Larynx (males) Thyroid (males) Ovaries Rectal (females) Urinary bladder (males) Lung (мужчины) The right scale is for incidence rates of lung cancer (males). The left scale is for all presented sites Years

22 Rate per population Skin (males) Rate per population Skin(females) Kidney (males) Prostate Thyroid (females) Years

23 Leukaemia (С91-С95) Chronic myeloid leukaemia (C92.1, C93.1, C94.1) Chronic lymphatic leukaemia (C91.1) Acute myeloid leukaemia (C92.0, C93.0, C94.0, C94.2, C94.4-C94.5) Acute lymphatic leukaemia (C91.0) Non-Hodgkin lymphoma (C82.0-C85.9, C96) С00-С96 All malignant C90 Multiple myeloma C81 Hodgkin lymphoma C73 Thyroid C71 Brain C67 Bladder C64 Kidney C62 Testis C61 Prostate C56 Ovary C54 Corpus uteri C53 Cervix uteri C50 Breast (MALES) C50 Breast (FEMALES) C45 Mesothelioma C44 Other skin C43 Melanoma of skin C40-41 Bone C33-34 Trachea, bronchus and lung C32 Larynx C25 Pancreas C23-24 Gallbladder etc. C22 Liver C20 Rectum C19 Rectosigmoid junction C18 Colon C16 Stomach C15 Oesophagus C12-13 Hypopharynx C11 Nasopharynx C07-08 Salivary glands C03-06 Mouth C01-02 Tongue C00 Lip

24 Leukaemia (С91-С95) Chronic myeloid leukaemia (C92.1, C93.1, C94.1) Chronic lymphatic leukaemia (C91.1) cute myeloid leukaemia (C92.0, C93.0, C94.0, C94.2, C94.4-C94.5) Acute lymphatic leukaemia (C91.0) Non-Hodgkin lymphoma (C82.0-C85.9, C96) С00-С96 All malignant C90 Multiple myeloma C81 Hodgkin lymphoma C73 Thyroid C71 Brain C67 Bladder C64 Kidney C62 Testis C61 Prostate C56 Ovary C54 Corpus uteri C53 Cervix uteri C50 Breast (MALES) C50 Breast (FEMALES) C45 Mesothelioma C44 Other skin C43 Melanoma of skin C40-41 Bone C33-34 Trachea, bronchus and lung C32 Larynx C25 Pancreas C23-24 Gallbladder etc. C22 Liver C20 Rectum C19 Rectosigmoid junction C18 Colon C16 Stomach C15 Oesophagus C12-13 Hypopharynx C11 Nasopharynx C07-08 Salivary glands C03-06 Mouth C01-02 Tongue C00 Lip

25 Leukaemia (С91-С95) Chronic myeloid leukaemia (C92.1, C93.1, C94.1) Chronic lymphatic leukaemia (C91.1) Acute myeloid leukaemia (C92.0, C93.0, C94.0, C94.2, C94.4-C94.5) Acute lymphatic leukaemia (C91.0) Non-Hodgkin lymphoma (C82.0-C85.9, C96) С00-С96 All malignant C90 Multiple myeloma C81 Hodgkin lymphoma C73 Thyroid C71 Brain C67 Bladder C64 Kidney C62 Testis C61 Prostate C56 Ovary C54 Corpus uteri C53 Cervix uteri C50 Breast (MALES) C50 Breast (FEMALES) C45 Mesothelioma C44 Other skin C43 Melanoma of skin C40-41 Bone C33-34 Trachea, bronchus and lung C32 Larynx C25 Pancreas C23-24 Gallbladder etc. C22 Liver C20 Rectum C19 Rectosigmoid junction C18 Colon C16 Stomach C15 Oesophagus C12-13 Hypopharynx C11 Nasopharynx C07-08 Salivary glands C03-06 Mouth C01-02 Tongue C00 Lip

26 Leukaemia (С91-С95) Chronic myeloid leukaemia (C92.1, C93.1, C94.1) Chronic lymphatic leukaemia (C91.1) Acute myeloid leukaemia (C92.0, C93.0, C94.0, C94.2, C94.4-C94.5) Acute lymphatic leukaemia (C91.0) Non-Hodgkin lymphoma (C82.0-C85.9, C96) С00-С96 All malignant C90 Multiple myeloma C81 Hodgkin lymphoma C73 Thyroid C71 Brain C67 Bladder C64 Kidney C62 Testis C61 Prostate C56 Ovary C54 Corpus uteri C53 Cervix uteri C50 Breast (MALES) C50 Breast (FEMALES) C45 Mesothelioma C44 Other skin C43 Melanoma of skin C40-41 Bone C33-34 Trachea, bronchus and lung C32 Larynx C25 Pancreas C23-24 Gallbladder etc. C22 Liver C20 Rectum C19 Rectosigmoid junction C18 Colon C16 Stomach C15 Oesophagus C12-13 Hypopharynx C11 Nasopharynx C07-08 Salivary glands C03-06 Mouth C01-02 Tongue C00 Lip

27 Leukaemia (С91-С95) Chronic myeloid leukaemia (C92.1, C93.1, C94.1) Chronic lymphatic leukaemia (C91.1) Acute myeloid leukaemia (C92.0, C93.0, C94.0, C94.2, C94.4-C94.5) Acute lymphatic leukaemia (C91.0) Non-Hodgkin lymphoma (C82.0-C85.9, C96) С00-С96 All malignant C90 Multiple myeloma C81 Hodgkin lymphoma C73 Thyroid C71 Brain C67 Bladder C64 Kidney C62 Testis C61 Prostate C56 Ovary C54 Corpus uteri C53 Cervix uteri C50 Breast (MALES) C50 Breast (FEMALES) C45 Mesothelioma C44 Other skin C43 Melanoma of skin C40-41 Bone C33-34 Trachea, bronchus and lung C32 Larynx C25 Pancreas C23-24 Gallbladder etc. C22 Liver C20 Rectum C19 Rectosigmoid junction C18 Colon C16 Stomach C15 Oesophagus C12-13 Hypopharynx C11 Nasopharynx C07-08 Salivary glands C03-06 Mouth C01-02 Tongue C00 Lip

28 Leukaemia (С91-С95) Chronic myeloid leukaemia (C92.1, C93.1, C94.1) Acute myeloid leukaemia (C92.0, C93.0, C94.0, C94.2, C94.4-C94.5) Acute lymphatic leukaemia (C91.0) Non-Hodgkin lymphoma (C82.0-C85.9, C96) С00-С96 All malignant C81 Hodgkin lymphoma C73 Thyroid C71 Brain C69 Eye C67 Bladder C64 Kidney C62 Testis C43 Melanoma of skin C22 Liver C20 Rectum C07-08 Salivary glands

29 PER All Adults (14+ years at diag.) Children (0-14 years at diag.) YEARS

30 Incidence rates of thyroid cancer by age groups (0-19) female (per )

31 Incidence rates of thyroid cancer by age groups (0-19) female (per )

32 Incidence rates of thyroid cancer by age groups (0-19) female (per )

33 Incidence rates of thyroid cancer by age groups (0-19) females (per ) They were born in

34 Leukaemia (С91-С95) Chronic myeloid leukaemia (C92.1, C93.1, C94.1) Acute myeloid leukaemia (C92.0, C93.0, C94.0, C94.2, C94.4-C94.5) Acute lymphatic leukaemia (C91.0) Non-Hodgkin lymphoma (C82.0-C85.9, C96) С00-С96 All malignant C81 Hodgkin lymphoma C73 Thyroid C71 Brain C69 Eye C67 Bladder C64 Kidney C62 Testis C43 Melanoma of skin C22 Liver

35 Leukaemia (С91-С95) Chronic myeloid leukaemia (C92.1, C93.1, C94.1) Acute myeloid leukaemia (C92.0, C93.0, C94.0, C94.2, C94.4-C94.5) Acute lymphatic leukaemia (C91.0) Non-Hodgkin lymphoma (C82.0-C85.9, C96) С00-С96 All malignant C81 Hodgkin lymphoma C73 Thyroid C71 Brain C69 Eye C67 Bladder C64 Kidney C62 Testis C43 Melanoma of skin C22 Liver C20 Rectum C07-08 Salivary glands

36 Leukaemia (С91-С95) Chronic myeloid leukaemia (C92.1, C93.1, C94.1) Acute myeloid leukaemia (C92.0, C93.0, C94.0, C94.2, C94.4-C94.5) Acute lymphatic leukaemia (C91.0) Non-Hodgkin lymphoma (C82.0-C85.9, C96) С00-С96 All malignant C81 Hodgkin lymphoma C73 Thyroid C71 Brain C69 Eye C67 Bladder C64 Kidney C62 Testis C43 Melanoma of skin C22 Liver C20 Rectum C07-08 Salivary glands

37 Thyroid Cancer Incidence

38 The contamination of the territory of Belarus with iodine-131 (reconstruction) estimated 10 May, 1986

39 SIR Liquidators Evaquees Residents

40 Per APC=0,3% в год Brest region Vitebsk region Gomel region Grodno region Minsk region Minsk city Mogilev region Belarus

41 Liquidators Evacuees Residents Offspring

42 Liquidators Evacuees Residents Offspring

43 Liquidators Evacuees Residents

44 Liqudators Evacuees Residents Offspring

45 Liquidators Evacuees Residents Offspring

46 SIR Liquidators Evacuees Residents

47 THANK YOU FOR YOUR ATTENTION

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