Management of Hyperthermic Intraperitoneal Chemotherapy (HIPEC) after Cytoreductive Surgery (CRS)

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1 Management of Hyperthermic Intraperitoneal Chemotherapy (HIPEC) after Cytoreductive Surgery (CRS) MARCH 2015 HAMBURG EUROPEAN SCHOOL OF PERITONEAL SURFACE ONCOLOGY

Management of Hyperthermic Intraperitoneal Chemotherapy (HIPEC) after Cytoreductive Surgery (CRS) Course directors Chair: Beate Rau, Charité Campus Mitte, Berlin, DE Co-Chair: Marcello Deraco,

2 Management of Hyperthermic Intraperitoneal Chemotherapy (HIPEC) after Cytoreductive Surgery (CRS) Course directors Chair: Beate Rau, Charité Campus Mitte, Berlin, DE Co-Chair: Marcello Deraco, Fondazione IRCCS Istituto Nazionale dei Tumori, Milano, IT Experts in the field Dario Baratti MD, Fondazione IRCCS Istituto Nazionale dei Tumori, Milano, IT Tom Cecil MD, Basingstoke and North Hampshire Hospital, Basingstoke, UK Olivier Glehen MD, Centre Hospitalier Lyon-Sud, Pierre Bénite, Lyon, FR Gabriel Glockzin MD, University of Regensburg, Regensburg, DE Santiago González-Moreno MD, MD Anderson Cancer Center, Madrid, ES Ludwig K. Groebler DVM, European Surgical Institute (ESI), Hamburg, DE Jens Hartmann MD, AKH, Celle DE Maik Kilian MD, Charité Campus Mitte, Berlin, DE Christhardt Köhler MD, Asklepios Klinik Hamburg, Hamburg, DE Shigeki Kusamura MD, Fondazione IRCCS Istituto Nazionale dei Tumori, Milano, IT Massimo Milione MD, Institute of Pathology, Fondazione IRCCS Istituto Nationale Tumori, Milano, IT Jörg Pelz MD, University of Wuerzburg, Wuerzburg, DE Pompiliu Piso MD, St. John of God Hospital, Regensburg, DE Paolo Proto MD, Fondazione IRCCS Istituto Nazionale dei Tumori, Milano, IT Horst-Geunter Rau, Amperklinikum, Dachau, DE Pascal Rousset MD, Centre Hospitalier Lyon-Sud, Pierre Bénite, Lyon, FR Paul H. Sugarbaker MD, Washington Cancer Center, Washington, US Peter Thuss-Patience MD, Charité Campus Virchow-Klinikum, Berlin, DE Kurt Van der Speeten MD, Ziekenhuis Oost-Limburg, Genk, BE Florent Wallet MD, Centre Hospitalier Lyon-Sud, Pierre Bénite, Lyon, FR Victor J. Verwaal MD, The Netherlands Cancer Institute, Amsterdam, NL

3 Aim of the Advanced Course The ESSO Advanced Course Management of HIPEC after CRS aims to discuss evidence-based clinical decision-making in the management of primary and secondary peritoneal cancer and will offer a multidisciplinary programme combining both practical aspects and theoretical problems. Technical and clinical approaches will be revisited and updated. Presentations will include the state of the art and latest advancements, videos with tips and tricks by the experts in the field, and case reports. Participants will perform cytoreductive surgery in small groups in the wet lab using several new technical devices with supervision by the experts. Therefore the workshop is limited to a small number of participants (first come first serve). Ideal Advanced Course Candidate Senior residents (last two years of training) Experienced consultant surgeons Good in English, written and spoken Educational Methods Interdisciplinary approach Plenary lectures Workshops Video discussions Case reports Hands on: several operations procedures in the operating room Textbook and Video Atlas edited by Paul Sugarbaker offered by FARGO (Foundation for Applied Research in Gastrointestinal Oncology) Partnerships ESSO acknowledges the collaboration of the European Surgical Institute (ESI) and the Berufsverband der Deutschen Chirurgen (BDC). Course Venue European Surgical Institute Hummelsbütteler Steindamm 71 D Norderstedt Tel. +49 (0) Website:

Course Accommodation Steigenberger Hotel Treudelberg Hamburg Lemsahler Landstraße 45 D-22397 Hamburg Tel. +49 40 608 22 0 Fax +49 40 608 22 8888 Website: www.treudelberg.

4 Course Accommodation Steigenberger Hotel Treudelberg Hamburg Lemsahler Landstraße 45 D Hamburg Tel Fax Website: Course coordination Ana Galán European Society of Surgical Oncology (ESSO) . Ana.galan@essoweb.org Application Procedure Application must include: Complete Application Form, available at (education/projects & courses) Short CV (maximum 2 pages) Applications must be sent by to Ana.galan@essoweb.org Participation fee The participation fee is 800 EUR for members and 950 EUR for non-members. It includes the registration to the 2-day course, 2-nights accommodation, coffee breaks and lunches and a social dinner. Accreditation An application for accreditation has been submitted to the European Accreditation Council for CME (EACCME) of the European Union of Medical Specialists (UEMS).

5 Programme 14:00-14:50 Introduction Thursday 19 March Beate Rau 14:50-16:50 Treatment principles for peritoneal surface malignancies: surgical approach and clinical-pathological pathway Chairs Beate Rau - Marcello Deraco 14:50-15:20 Techniques of cytoreductive surgery with peritonectomy procedures (CRS) Paul Sugarbaker 15:20-15:35 Pharmacology of different techniques of Intraperitoneal drug administration; role of heat and carriers Kurt Van der Speeten 15:35-15:50 HIPEC: different techniques and role of intra abdominal pressure Shigeki Kusamura 15:50-16:05 Clinical diagnostic pathway for PSM Dario Baratti 16:05-16:20 Pathological diagnostic pathway for PSM Massimo Milione 16:20-17:00 Coffee Break 17:00-18:45 Perioperative Management Chairs Paul Sugarbaker - Tom Cecil 17:00-17:15 OR personnel safety related to HIPEC Jörg Pelz 17:15-17:30 Preoperative staging in peritoneal metastases: necessary and nice to have (morphologic exams and peritoneal carcinomatosis) Pascal Rousset 17:30-17:45 To speak the same language: PCI, CCR and PSS Gabriel Glockzin 17:45-18:00 Perioperative management of CRS and HIPEC: view of anaesthesiologist Paolo Proto 18:00-18:15 Prevention and management of postoperative general complications Florent Wallet 18:15-18:30 Prevention and management of postoperative surgical complications related to CRS and HIPEC Maik Kilian 18:30-18:45 How to start a new center for the treatment of PSM Shigeki Kusamura

6 Friday 20 March 08:30-17:30 Operation room: hands on Tutors Dario Baratti, Tom Cecil, Marcello Deraco, Olivier Glehen, Gabriel Glockzin, Santiago González-Moreno, Jens Hartmann, Christhardt Köhler, Maik Kilian, Shigeki Kusamura, Jörg Pelz, Pompiliu Piso, Beate Rau, Horst-Geunter Rau, Paul Sugarbaker, Kurt Van der Speeten, Vic Verwaal 08:30-08:40 Preparation for the hands on: anatomical structure in animal Ludwig K. Groebler 08:40-08:50 Debreefing from human to animal Beate Rau 08:40-11:05 Right upper abdomen 11:05-11:25 Coffee Break Right abdominal wall Interenteric Right diaphram arcus tendineum Resection gastric surface Bursa omentalis Splenectomy Pancreatic tail resection 11:25-12:30 Left upper abdomen 12:30-13:30 Lunch Left abdominal wall Left diaphram arcus tendineum Resection of serosal surface of bowel mesenterium Hepatoduodenal ligament Cholecystectomy Resection of small bowel Triangle ligament Morrison pouch 13:30-14:30 Pelvic 14:30-15:00 Coffee Break Resection of omentum Resection of serosal surface of bowel Resection of peritoneal surface of the bladder Lymph node preparation central mesenterical route 15:00-15:30 Devices HIPEC open and devices HIPEC close 16:00-17:30 Discussion with the experts1

7 Saturday 21 March :30-10:40 Frequent indications and systemic treatment Chairs Pompiliu Piso - Santiago González-Moreno 08:30-08:50 Pseudomyxoma peritonei (particularities of CRS, HIPEC and CCR score) Tom Cecil 08:50-09:10 Malignant peritoneal mesothelioma and primay peritoneal carcinoma (particularities of CRS, HIPEC and CCR score) Marcello Deraco 09:10-09:30 Peritoneal metastases from ovarian cancer (particularities of CRS, HIPEC and CCR score) Christhardt Köhler 09:30-09:50 Peritoneal metastases from gastric cancer (particularities of CRS, HIPEC and CCR score) Santiago González-Moreno 09:50-10:10 Peritoneal metastases from colorectal cancer (particularities of CRS, HIPEC and CCR score) Vic Verwaal Treatment options in peritoneal metastases from gastrointestinal origin: the medical oncology point of view Peter Thuss-Patience Ongoing clinical trials on G.I. cancer Olivier Glehen 10:40-11:10 Coffee Break 11:10-13:00 Selection is the key! Case reports (Videos) Chairs Christhardt Köhler - Marcello Deraco 11:10-11:30 Selection criteria for CRS and HIPEC Pompiliu Piso 11:30-11:45 Case 1 (PCI, SCORE, strategy, prognosis) Colorectal Cancer Vic Verwaal 11:45-12:00 Case 2 (PCI, SCORE, strategy, prognosis) Ovarian Cancer Christhardt Köhler 12:00-12:15 Case 3 (PCI, SCORE, strategy, prognosis) Mesothelioma Dario Baratti 12:15-12:30 Case 4 (PCI, SCORE, strategy, prognosis) Gastric Cancer Jens Hartmann 12:30-13:00 Conclusions and end of the course

8 ESSO is grateful for the continuous support of its corporate sponsors The advanced course is supported by: European Society of Surgical Oncology (ESSO) Avenue E. Mounier 83 B 1200 Brussels Tel: +32 (0) Fax : +32 (0) info@essoweb.org Website :

Beate Rau, Charité University of Berlin Campus Virchow-Klinikum, Berlin, DE François Quenet, Centre Régional du Cancer, Montpellier, Montpellier, FR

Chairs Beate Rau, Charité University of Berlin Campus Virchow-Klinikum, Berlin, DE François Quenet, Centre Régional du Cancer, Montpellier, Montpellier, FR Faculty members Frédéric Bibeau, Caen University