CME. Personalized Medicine. Annual Oncology Symposium: Friday, May 8, Glaser Auditorium Swedish First Hill 747 Broadway Seattle, Wash.

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1 Annual Oncology Symposium: Personalized Medicine CME CONTINUING MEDICAL EDUCATION Friday, May 8, 2015 Glaser Auditorium Swedish First Hill 747 Broadway Seattle, Wash.

2 Needs statement Personalized medicine is defined by the National Cancer Institute as a form of medicine that uses information about a person s genes, proteins and environment to prevent, diagnose and treat disease. Breakthroughs in molecular biology research have enabled genomic testing on a patient s cancer which can provide vital information about the treatment options for that individual and increase his or her chance of survival. Cancer care is rapidly evolving to a model where the patient s individual genomic profile is utilized in defining approaches to risk assessment, prevention, screening, early diagnosis, therapeutics and survivorship. Ultimately, the unique attributes of the person, and his or her cancer, will determine appropriate interventions, as opposed to focusing solely on the site of anatomic origin. These methods are still in early stages and many centers do not have the knowledge of these research programs and treatment options, creating a need to educate those involved in the care of cancer patients about these new technologies, tools and approaches to improve the outcomes of cancer patients. Additionally, while the biomedical treatment of cancer is advancing, the medical community often fails to address the needs of the whole patient and their families, including psychological and psychosocial problems worsened by the disease. Recent research has proven the positive effects of addressing these and other nonmedical issues, with a resulting improvement in patient outcomes. Due to limited skill training in this area during medical school, there is a need to provide further education, tools and techniques to all health care professionals involved in the care of cancer patients. Through didactic lectures and multidisciplinary panels, this symposium will review the tools and techniques health care professionals can and should utilize to address not only the medical needs of cancer care, but the overall needs of the whole patient and their families to ultimately improve patient care and outcomes. Course description Personalized medicine is a disruptive innovation, part of the paradigm shift from volume-based to value-based, reactive to predictive, and passive to participatory health care. The goal of this symposium is to introduce personalized medicine to all health care professionals involved in the care of cancer patients, emphasizing the double meaning: one, caring for the whole patient, i.e., addressing the socioeconomic, psychological, environmental and integrative medicine needs of patients and their families; and two, using genomic and epigenomic alterations to identify personalized approaches to cancer risk assessment, prevention, screening, diagnosis, therapeutics and survivorship. Participants will learn practical applications for integrating genomic medicine, research and holistic approaches to personalize patient care. Accreditation Accreditation with commendation Swedish Medical Center is accredited by the Accreditation Council for Continuing Medical Education to provide continuing medical education for physicians. AMA PRA Category 1 Credits Swedish Medical Center designates this live activity for a maximum of 7 AMA PRA Category 1 Credits. Physicians should claim only the credit commensurate with the extent of their participation in the activity. AAFP prescribed credits Application for CME credit has been filed with the American Academy of Family Physicians. Determination of credit is pending. Nursing CE contact hours 7.0 nursing contact hours will be provided by Swedish Medical Center Clinical Education and Practice, an approved provider of continuing nursing education by the Washington State Nurses Association Continuing Education Approval & Recognition Program (CEARP), an accredited approver by the American Nurses Credentialing Center s Commission on Accreditation. For further information Phone: Fax: cme@swedish.org Web:

3 Agenda 7:20 a.m. Registration and continental breakfast 7:50 a.m. Welcome and introductions 8 a.m. Biology of Genomic Medicine: Next Generation Clinical Trials in the Era of Personalized Medicine C. Anthony Blau, M.D. 8:40 a.m. Estrogen Receptor Positive Breast Cancer: A Model for Targeted Therapy Robert B. Livingston, M.D. 9:20 a.m. Break 9:40 a.m. Ethics, Access and Disparities in Care Wylie Burke, M.D., Ph.D. 10:20 a.m. Palliative Care and Oncology in the Era of Personalized Medicine Ira Byock, M.D. 11:20 a.m. Morning panel Moderator: Thomas Brown, M.D., MBA Participants: C. Anthony Blau, M.D.; Ira Byock, M.D.; Wylie Burke, M.D., Ph.D.; Robert B. Livingston, M.D. 11:45 a.m. Lunch 12:40 p.m. Economics of and Access to Genomic Medicine Scott Ramsey, M.D., Ph.D. 1:20 p.m. Molecular Pathology Practical Guide to Modern Cancer Care Anna B. Berry, M.D. 1:45 p.m. Integrating NGS, Immunoprofiling and Microbiome Analysis to Stratify Patients for Clinical Trials and Ultimately Tailor Immunotherapy for Patients with Cancer Bernard A. Fox, Ph.D. 2:10 p.m. Break 2:25 p.m. Host-Pathogen Relationships and their Relevance in Cancer Delphine J. Lee, M.D., Ph.D., FAAD 2:50 p.m. Personalized Medicine for Primary Brain Tumors and Novel Translational Research at the Ben and Catherine Ivy Center for Advanced Brain Tumor Treatment Charles S. Cobbs, M.D. 3:15 p.m. Afternoon panel Moderator: John M. Pagel, M.D., Ph.D. Participants: Anna B. Berry, M.D.; Charles S. Cobbs, M.D.; Bernard A. Fox, Ph.D.; Delphine J. Lee, M.D., Ph.D., FAAD; Scott Ramsey, M.D., Ph.D. 3:45 p.m. Extraordinary Caring in Practice Patient Case Discussion Moderator: Ellyn M. Lee, M.D., FACP Participants: Sandra S. Johnson, MSW, LICSW; Barbara Kollar, MCHES, MHA; Robert Resta, MS; David S. Zucker, M.D., Ph.D. 4:30 p.m. Adjourn Intended audience This conference is targeted toward all health care workers involved in the care of oncology patients, including physicians, midlevel providers, nurses, pharmacists, allied health professionals, residents/fellows and researchers. It is especially relevant for the following specialties: medical oncology, radiation oncology, surgery, pathology, primary care, family medicine, internal medicine, research, genetic counseling, palliative care, social work and naturopathy. Acknowledgments This symposium is financially supported in part by educational grants in accordance with ACCME s Standards for Commercial Support. At the time of this printing, a complete listing of commercial supporters was not available. Appropriate acknowledgment will be given to all supporters at the time of the symposium.

4 Course objectives At the conclusion of this symposium, the participant will provide better patient care through an increased ability to: List three obstacles associated with traditional clinical trial designs in patients with cancer, describe the features of next generation clinical trials in patients with cancer and name two regulatory issues that may significantly impact the development of clinical trials in patients with cancer Review rationale for combined endocrine therapies, describe likely mechanisms of endocrine resistance and discuss second generation only development targeted to resistance mechanisms Describe three ways in which genomic research can contribute to oncology care and identify the potential impacts of genomic testing in health care disparity Identify at least four of the six characteristics of high quality care (safe, effective, patient-centered, timely, efficient and equitable); distinguish advance directives from plans for care, DNR orders and Comfort Measure Only orders; and recognize potentially valuable clinical goals in caring for patients who are facing the end of their lives, such as: completion of affairs and relationships, a sense of well-being, affirming inherent dignity and honoring and celebrating their lives Review genomic medicine and palliative care recommendations with expert faculty Review comparative effectiveness research and how it applies in oncology, apply approaches to estimate the comparative effectiveness of genomically driven cancer care and discuss how payment models can be used to improve the evidence base for genomically driven cancer care Explain, in broad terms, the basic technology used in cancer genomics; describe the utility of genomic testing in cancer care and devise a strategy for practical implementation of genomic testing for cancer patients Review the impact of the human microbiome on cancer and discuss immunologic impact of the gut microbiome Review the basic biology of glioblastoma cancer stem cells, discuss the concept of high throughput screening for cancer stem cell inhibitors and recognize the clinical trial design for personalized medicine utilizing combination therapy based on high throughput screening for cancer stem cell inhibitors Review the role of genomic medicine in cancer care with expert faculty and discuss practical applications for integrating genomic medicine, research and holistic approaches to personalize patient care Discuss treatment guidelines to provide whole patient care, utilize complementary treatment methods in the treatment of cancer care and review the effects of cancer treatment on patients through patient cases Location Swedish Medical Center is located at 747 Broadway in Seattle, Wash. The conference will be held in the Glaser Auditorium on the first floor of the medical center. Parking is available in the Broadway Garage at 747 Broadway at a maximum fee of $15. From Interstate 5, northbound and southbound, take the James Street exit. Travel east on James Street. Turn left (north) onto Broadway. Turn left into the main hospital entrance and follow the signs to the Broadway underground parking garage. Planning committee Thomas Brown, M.D., MBA, course chair Anna B. Berry, M.D. Caye Boosalis, CME manager Patricia L. Dawson, M.D., Ph.D., FACS Selin Demir Charles W. Drescher, M.D. Philip J. Gold, M.D. Mariko Tameishi Nancy Thompson, MSN, RN, AOCNS Danielle Westley, CME specialist

5 Annual Oncology Symposium: Personalized Medicine Faculty Anna B. Berry, M.D. Scientific director, Personalized Medicine Program Medical director of Molecular Diagnostics Cellnetix Pathology & Laboratories Clinical associate professor University of California, San Francisco C. Anthony Blau, M.D. Professor of medicine/hematology Adjunct professor of genome sciences Director, Center for Cancer Innovation Co-director, Institute for Stem Cell and Regenerative Medicine Thomas Brown, M.D., MBA Executive director Wylie Burke, M.D., Ph.D. Professor, Department of Bioethics and Humanities Ira Byock, M.D. Chief medical officer Providence Institute for Human Caring Torrance, Calif. Charles S. Cobbs, M.D. Medical director Ben and Catherine Ivy Center for Advanced Brain Tumor Treatment Neurosurgeon Swedish Neuroscience Institute Bernard A. Fox, Ph.D. Harder Family Endowed Chair for Cancer Research Member and chief, Molecular and Tumor Immunology Robert W. Franz Cancer Research Center Earle A. Chiles Research Institute Providence Cancer Center Knight Cancer Institute and Department of Molecular Microbiology and Immunology Oregon Health and Science University Barbara Kollar, MCHES, MHA Director of Supportive Care Services Sandra S. Johnson, MSW, LICSW Manager, Oncology Social Work Delphine J. Lee, M.D., Ph.D., FAAD Director, Carolyn Dirks and Brett Dougherty Laboratory for Cancer Research Director, Translational Immunology Department John Wayne Cancer Institute at Providence Saint John s Health Center Ellyn M. Lee, M.D., FACP Medical director, Palliative Care Robert B. Livingston, M.D. Professor of medicine The University of Arizona Cancer Center John M. Pagel, M.D., Ph.D. Chief of Hematologic Malignancies Program Director of Hematopoietic Stem Cell Transplantation Program Scott Ramsey, M.D., Ph.D. Director, Hutchinson Institute for Cancer Outcomes Research, Public Health Sciences Fred Hutchinson Cancer Research Center Adjunct professor, Department of Health Services Comprehensive Cancer Prevention, Early Detection, and Survivorship Program Seattle Cancer Care Alliance Professor of medicine, Division of General Internal Medicine Professor (adjunct), Pharmaceutical Outcomes, Research, and Policy Program, Department of Pharmacy Robert Resta, MS Certified/licensed genetic counselor Hereditary Cancer Clinic David S. Zucker, M.D., Ph.D. Medical director and program leader Cancer Rehabilitation Services

6 Registration information: Preregistration is required as space is limited. Participants who register by the advance registration deadline will receive a confirmation postcard after Monday, April 27. Registrations will only be processed when accompanied by full payment. If using the registration form, please mail or fax it to: Continuing Medical Education Swedish Medical Center 747 Broadway Seattle, WA Fax: Cancellation: To receive a refund, notice of cancellation must be received no later than Friday, May 1, Please note: No registrations are accepted by phone or . If you have special needs, please contact the CME office at Registration fees: The fee for this course includes catering, all instruction materials, online syllabus access and a certificate of AMA PRA Category 1 Credits. Save time register online! R E G I S T R A T I O N Annual Oncology Symposium: Personalized Medicine Friday, May 8, 2015 Please print or type information NAME ADDRESS CITY/STATE/ZIP PHONE FAX EMERGENCY CONTACT NAME AND PHONE NUMBER (OPTIONAL) SPECIALTY F O R M TITLE/CREDENTIALS Registration fees: Please check one of the following: Advance Registration After April 27 M.D. or D.O. $245 $275 Allied health professional $125 $155 Medical student No charge Resident or fellow No charge Payment: Check enclosed, payable to: Swedish CME Credit card # VISA MasterCard Discover AMEX Signature Expiration date PLEASE DETACH

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