Genetic polymorphisms in the TERT-CLPTM1L region and lung cancer susceptibility in Chinese males
|
|
- Priscilla Harvey
- 6 years ago
- Views:
Transcription
1 1588 Genetic polymorphisms in the TERT-CLPTM1L region nd lung cncer susceptibility in Chinese mles XUYANG XIAO 1 nd WUBIN HE 2 1 Deprtment of Thorcic Surgery nd 2 Biologicl Therpy Center Lbortory, The First Affilited Hospitl of Jinzhou Medicl University, Jinzhou, Lioning , P.R. Chin Received Jnury 25, 2017; Accepted My 18, 2017 DOI: /ol Abstrct. The objective of the present study ws to nlyze the reltionship between genetic polymorphisms of the rs locus of the telomerse reverse trnscriptse (TERT) gene nd the rs locus of the cleft lip nd plte trnsmembrne protein 1 (CLPTM1L) gene nd the risk of developing lung cncer in mles in Jinzhou. A totl of 214 lung cncer ptients who were dmitted in Jinzhou Medicl University were nlyzed, nd 216 helthy mles were selected s controls. Venous blood from ll subjects nd dt on relevnt risk fctors were collected. DNA ws extrcted from peripherl blood by the phenol-chloroform method. Rel-time fluorescent quntittive PCR (TqMn rel time PCR) ws used for DNA mplifiction. The genotyping results of the genetic polymorphisms of the TERT rs nd CLPTM1L rs loci were detected. The risk of developing lung cncer in the popultion with the TERT rs locus crrying the T llele ws times tht with the TERT rs locus crrying the C llele fter djustment of the ge fctor. The risk of developing lung cncer in the popultion crrying the TT mutnt genotype nd the CT genotype incresed significntly compred with tht crrying the CC wild genotype [odds rtio (OR)=1.815, 95% CI= ; OR=2.417, 95% CI= ]. Bsed on comprison between the combintion of the two mutnt genotypes (CT+TT) nd the wild homozygous genotype (CC), the mutnt genotype incresed the risk of developing lung cncer (OR=1.955, 95% CI= ). The risk of developing lung cncer in the popultion with the CLPTM1L rs locus crrying the T llele ws times tht crrying the C llele (OR=1.343, 95% CI= ). The popultion with the TERT rs locus crrying the mutnt genotype (CT+TT) ws ssocited with the number of tumors Correspondence to: Dr Wubin He, Biologicl Therpy Center Lbortory, The First Affilited Hospitl of Jinzhou Medicl University, 2 People's Street, Gut, Jinzhou, Lioning , P.R. Chin E-mil: w0f8v5@163.com Key words: telomerse reverse trnscriptse, cleft lip nd plte trnsmembrne protein 1, lung cncer, mononucleotide polymorphism, hereditry susceptibility (OR=0.553, 95% CI= ). In conclusion, in mles, the TERT rs nd CLPTM1L rs T lleles re the susceptibility fctors for developing lung cncer. Individuls, including the smoking popultion, who crry both the TERT rs nd CLPTM1L rs T lleles re more likely to develop lung cncer. Introduction Tumorigenesis is multi-fctor, multi-stge, nd multi-gene process. In ddition to environmentl fctors, dietry fctors, biologicl fctors, nd hereditry fctors ply importnt roles in tumor progression (1,2). Genetic susceptibility is determined by single nucleotide on the individul genome (3,4). During tumorigenesis, environmentl fctors ply n inititing role, while hereditry fctors determine the susceptibility of individuls to tumorigenesis. In recent yers, reserch on genetic susceptibility to tumors hs ttrcted much ttention. Recent reserch in moleculr epidemiology hs imed to identify nd determine the mutnt loci of tumor-relted genes, nd further study the interctions between the environment nd genes, nd the interctions between genes by studying mononucleotide polymorphisms (4). Within DNA sequence, polymorphisms rising from muttion of single nucleotide (A, T, C, nd G) re clled single nucleotide polymorphisms (SNPs) (5). SNPs re mjor form of genome polymorphism (6). The gene coding region of n SNP is clled coding region SNP (csnp), which my led to chnges in the mino cid sequence of proteins, nd chnges in protein function. csnps hve importnt biologicl significnce (7). Bsed on estimtion, 1 in 1,000 people hve one SNP in the genome. The 3 billion humn bsic groups hve totl of over 3 million SNPs (8). Different individuls hve different susceptibilities to crcinogenic fctors in the environment becuse of polymorphisms. Therefore, SNPs cn be used to screen popultions susceptible to tumors in rpid nd lrge-scle mnner. Reserch on SNPs relted to tumors hs lso been focus in moleculr epidemiology in recent yers. The chromosome 5p15.33 region hs two known genes, humn telomerse reverse trnscriptse (TERT) nd cleft lip nd plte trnsmembrne protein 1 (CLPTM1L) (9-11). These genes hve multiple cncer risk loci nd my be ssocited with tumorigenesis. TERT is the ctlytic subunit of telomerse, nd is locted on chromosome 5p It spns 35 kb, nd comprises 16 exons
2 XIAO nd HE: GENETIC POLYMORPHISMS IN THE TERT-CLPTM1L REGION AND LUNG CANCER SUSCEPTIBILITY 1589 nd 15 introns. It is rte-limiting fctor for synthesizing the telomerse holoenzyme (12). Its expression correltes with the expression of telomerse. Chnges in TERT cn lso reflect corresponding chnges in the ctivity of intrcellulr telomerse (13). TERT is n importnt trget site for inhibiting telomerse ctivity. TERT cn increse the risk of tumors by influencing telomerse ctivity nd telomere length. In ddition, telomerse prticiptes in processes such s poptosis, DNA dmge repir, nd regultion of gene expression, thus influencing tumorigenesis nd progression (14,15). The CLPTM1L gene encodes for trnsmembrne protein, which induces poptosis in cispltin-resistnt cell lines. It is expressed in multiple norml nd mlignnt tissues such s the skin, lung, ovry, cervix, nd thymus (16,17). However, the functions of CLPTM1L, nd its role in tumorigenesis remin uncler. At present, CLPTM1L hs been confirmed to be overexpressed in humn ovrin tumor cell lines nd is resistnt to cispltin. CLPTM1L overexpression in pulmonry tumor cells cn protect them from poptosis induced by genotoxic stress, indicting tht it my hve ntipoptotic function. CLPTM1L is lso highly expressed in other tumor tissues. The forementioned observtions suggest tht CLPTM1L my be ssocited with the genesis of multiple tumor types. The genome-wide ssocition study reported tht the SNPs, TERT rs nd CLPTM1L rs401681, re significntly correlted with cncer risk (18). Regrding reserch on the reltionship between genetic polymorphisms of specific loci nd lung cncer susceptibility, Zhng et l studied the reltionship between the genetic polymorphism t rs , nd the risk of developing lung cncer in 400 lung cncer ptients nd 400 helthy subjects (controls) in the Asin popultion in Their results showed tht genetic muttion t the rs locus increses the risk of developing lung cncer (19). Currently, there is no reserch on the reltionship between the rs locus nd the risk of developing lung cncer. Using cse-control design method, the im of the present study ws to nlyze the reltionship between the genetic polymorphism of the rs locus of the TERT gene nd the rs locus of the CLPTM1L gene nd the risk of developing lung cncer in mles in Jinzhou city. Ptients nd methods Selection of reserch subjects. Mle ptients definitely dignosed with lung cncer bsed on histopthology who received opertive tretment in Grde 3, Clss A hospitls in Jinzhou city were selected, with cse-control reserch method, nd ssigned to the cse group. Inclusion criteri for the cse group: i) mle; ii) primry lung cncer, excluding metsttic lung cncer nd iii) received no chemotherpy or rdioctive therpy. A totl of 201 lung cncer ptients ged from 30 to 87 yers who sought medicl dvice in Grde 3, Clss A hospitls in Jinzhou city from 2008 to 2013 were included s reserch subjects. In ddition, 211 helthy mles who underwent physicl exmintions in the physicl exmintion center during the corresponding period were selected s controls using the frequency mtching method. All reserch subjects signed n informed consent form. Next, blood smples from ll reserch subjects were collected. Dt on demogrphic chrcteristics, relevnt clinicl indexes, nd exposure to environmentl fctors were obtined by questionnires. This study ws pproved by the Ethics Committee of the First Affilited Hospitl of Jinzhou Medicl University. Signed written informed consents were obtined from ll prticipnts before the study. Epidemiologicl investigtion. Uniformly prepred questionnires were used. An epidemiologicl investigtion into the reserch subjects ws mde by two trined investigtors. The content of the investigtion included demogrphic dt (nmes nd ges), smoking history, nd clinicl indexes. Non-smokers referred to individuls who smoked <100 cigrettes in their lives. The relevnt clinicl indexes were grouped ccording to the rnge of stndrd reference vlues. All investigtion dt were checked repetedly nd coded. A dtbse ws estblished with the EpiDt softwre version 3.5 (Tree str Inc., Ashlnd, OR, USA), nd dt were entered. DNA extrction. Frozen nticogulted blood from lung cncer ptients ws thwed in wter bth t 37 C. A totl of 1 ml of whole blood ws tken, nd 4 ml of erythrocyte lysis buffer (Sigm-Aldrich, St. Louis, MO, USA) ws dded. Smples were shken sufficiently, mixed well, nd llowed to stnd for 30 min. Smples were centrifuged t x g, nd the superntnt ws discrded. A totl of 1 ml of the buffer + 11 ml protese K (Qigen, Vlenci, CA, USA) were dded nd shken in wter bth for 20 h t 37 C until the leukocyte blocks disppered. An equl volume of blnce phenol (Qigen) ws dded. Smples were inverted gently for 10 min, nd centrifuged t 1,006.2 x g. The superntnt ws pipetted into 5 ml EP tubes. This step ws repeted once. An equl mount of 24:1 chloroform-isomylol (Promeg Corportion, Mdison, WI, USA) ws dded. Smples were shken gently for 10 min, nd centrifuged t 1,006.2 x g. The superntnt ws then pipetted. This step ws repeted once. The superntnt ws pipetted into 2 ml EP tubes. Cold nhydrous ethnol ws dded (Beijing Chemicl Regent Co., Ltd., Beijing, Chin). Smples were centrifuged t 10,500 x g for 10 min. The superntnt ws discrded. A totl of 200 ml of 70% ethnol ws dded. Smples were wshed twice. Smples were then inverted slowly for 1 min, nd centrifuged t 10,500 x g for 10 min. The superntnt ws discrded. Smples were ir dried t room temperture. A totl of 100 ml of TE ws dded to dissolve the DNA. The OD vlue (Thermo Fisher Scientific, Wlthm, MA, USA) ws mesured. Smples were plced t -20 C. Rel-time PCR genotyping. The TqMn genotyping technique ws used for the detection of TERT rs nd CLPTM1L rs polymorphisms. The PCR TqMn probe nd primers were designed nd synthesized by ABI PE Applied Biosystems (Foster City, CA, USA). TqMn Mster mix ws from ABI PE Applied Biosystems. PCR rection system: 2.50 µl of 2x TqMn Mster mix, 0.25 µl of 20x primer nd probe mixture, 1.25 µl of H 2 O, nd 1.00 µl of DNA, for totl of 5.00 µl. PCR mplifiction conditions: PCR rections nd fluorescence signl reding were performed on n ABI 7500 fluorescent quntittion PCR mplifier (ABI PE Applied Biosystems). The mplifiction conditions were s
3 1590 Tble I. Bsic informtion on the cse group nd control group. Chrcteristics Cse group (%) Control group (%) P-vlue Mles Averge ge 56.36± ± Smokers 130 (60.7) 82 (34.1) Non-smokers 84 (39.3) 134 (64.4) CRP 161 (75.23) SCCA (mg/l) 56 (26.1) CEA (mg/l) 78 (36.4) TNM stge I+II 90 (42.0) TNM stge III+IV 124 (58.0) No lymphtic metstsis 182 (85.0) Lymphtic metstsis 32 (15.0) No. of tumors =1 105 (49.0) 2 99 (51.0) Two-sided test; the differences were considered sttisticlly significnt when P<0.05. CRP, C-rective protein; SCCA, squmous cell crcinom ntigen; CEA, crcinoembryonic ntigen; TNM, tumor-node-metstsis. follows: pre-denturtion for 10 min t 95 C; denturtion for 30 sec t 92 C, nneling nd extension for 1 min t 60 C, for 47 cycles in totl. SDS softwre version 4.0 (ABI PE Applied Biosystems) ws used for genotype nlysis. The genotypes of smples were judged by detecting FAM nd VIC fluorescence intensity mrked by different lleles of the sme gene. Sttisticl nlysis. SPSS 19.0 softwre (SPSS, Inc., Chicgo, IL, USA) ws used for dt nlysis. A two-sided test ws conducted to detect the differences in distribution of demogrphic chrcteristics, relevnt risk fctors, nd SNP genotype between the cse group nd control group. P<0.05 ws considered sttisticlly significnt. The logistic regression model ws used to compute the odds rtio (OR) of vrious fctors nd their 95% confidence intervl (95% CI), nd nlyze the reltionship between genetic polymorphisms nd the risk of developing lung cncer. Results Generl conditions of reserch subjects. The bsic conditions of the cse group nd control group re shown in Tble I. A totl of 214 mle lung cncer ptients nd 216 helthy mles were included s reserch subjects. The ges of the cse group nd control group rnged from 30 to 86 yers. The verge ge of the cse group ws 56.36±10.43 yers, nd the verge ge of the control group ws 57.27±12.32 yers. There were no significnt differences in ge between the two groups (P=0.513). Bsed on sttisticl nlysis, there were no significnt differences in distribution of ptients with or without history of smoking between the cse group nd control group (P=0.256). The distribution of relevnt clinicl indexes of the lung cncer ptients [crcinoembryonic ntigen, tumor-nodemetstsis (TNM) stging, lymphtic metstsis, nd number of tumors] is shown in Tble I. Figure 1. Detection of the genotype of the TERT rs locus. The red points represent CC homozygous individuls. The blue points represent TT homozygous individuls. The green points represent CT heterozygous individuls. TERT, telomerse reverse trnscriptse. Distribution of TERT nd CLPTMlL polymorphism genotypes nd the reltionship between the distribution nd risk of developing lung cncer in mles. The genotypes of the TERT rs nd CLPTM1L rs loci re shown in Fig. 1. The verticl coordintes represent the C lleles, nd the horizontl coordintes represent the T lleles.
4 XIAO nd HE: GENETIC POLYMORPHISMS IN THE TERT-CLPTM1L REGION AND LUNG CANCER SUSCEPTIBILITY 1591 Tble II. Reltionship between the genetic polymorphism of TERT nd CLPM1L nd lung cncer susceptibility in mles. Genotype Cse group Control group P-vlue OR (95% CI) TERT rs CC CT ( ) TT ( ) CT+TT ( ) T llele ( ) CLPTM1L rs CC CT ( ) TT ( ) CT+TT ( ) T llele ( ) The OR vlue ws subjected to ge correction. The differences were considered sttisticlly significnt t P<0.05. TERT, telomerse reverse trnscriptse; CLPTM1L, cleft lip nd plte trnsmembrne protein 1; OR, odds rtio. Tble III. Reltionship between the joint ction of the genetic polymorphism of TERT nd CLPTM1L nd lung cncer susceptibility in mles. TERT rs CLPTM1L rs Cse group Control group P-vlue OR (95% CI) CC CC 23 6 CC CT+TT ( ) CT+TT CC ( ) CT+TT CT+TT < ( ) The OR vlue ws subjected to ge correction. The differences were considered sttisticlly significnt t P<0.05. TERT, telomerse reverse trnscriptse; CLPTM1L, cleft lip nd plte trnsmembrne protein 1; OR, odds rtio. Reltionship between the genetic polymorphisms of TERT nd CLPTM1L nd lung cncer susceptibility in mles. The genotype frequencies of the two genetic loci, TERT rs nd CLPTM1L rs401681, in both the cse group nd control group complied with Hrdy-Weinberg equilibrium. The polymorphisms of the two genetic loci nd the distribution of the lleles in both groups re shown in Tble II. The results showed tht the risk of developing lung cncer in the popultion with the TERT rs locus crrying the T llele ws times the risk of developing lung cncer in the popultion crrying the C llele (OR=1.614, 95% CI= ) following djustment of the ge fctor. Furthermore, the risk of developing lung cncer in the popultion crrying the TT mutnt gene nd the CT genotype incresed significntly compred with tht in the popultion crrying the CC wild genotype. The differences were sttisticlly significnt (OR=1.815, 95% CI= ); (OR=2.417, 95% CI= ). In ddition, bsed on comprison between the combintion of two mutnt genotypes (CT+TT) nd the wild homozygous genotype (CC), the mutnt genotype incresed the risk of developing lung cncer. The differences were sttisticlly significnt (OR=1.955, 95% CI= ). The risk of developing lung cncer in the popultion crrying the T llele t the CLPTM1L rs locus ws times the risk of developing lung cncer in the popultion crrying the C llele (OR=1.343, 95% CI= ). Bsed on comprison between the combintion of two mutnt genotypes (CT+TT) nd the wild homozygous (CC) genotype, the mutnt genotype incresed the risk of developing lung cncer. The differences were sttisticlly significnt (OR=1.744, 95% CI= ). Next, the genetic polymorphisms of the TERT rs nd CLPTM1L rs loci were combined to nlyze the joint ction of the two genes. The results of nlysis re shown in Tble III. The risk of developing lung cncer in individuls with mutnt genotypes of the TERT rs nd CLPTM1L rs loci incresed significntly (OR=4.457, 95% CI= ). The differences were sttisticlly significnt. The results in Tble IV show tht individuls crrying the mutnt genotypes (CT+TT), CC of TERT rs , nd mutnt genotype (CT+TT) of CLPTMlL rs in the smoking popultion hd significntly higher risk of developing lung cncer compred with those crrying the wild homozygous genotype (CC) in the non-smoking popultion (OR=2.348, 95% CI= ; OR=2.785, 95% CI= ). The differences were sttisticlly significnt.
5 1592 Tble IV. Reltionship between the joint ction of genetic polymorphism of TERT nd CLPTM1L nd smoking, nd lung cncer susceptibility in mles. Smokers Genotype Cse group Control group P-vlue OR (95% CI) TERT rs CC CT+TT ( ) + CC ( ) + CT+TT ( ) CLPTM1L rs CC CT+TT ( ) + CC ( ) + CT+TT ( ) The OR vlue ws subjected to ge correction. The differences were considered sttisticlly significnt t P<0.05. TERT, telomerse reverse trnscriptse; CLPTM1L, cleft lip nd plte trnsmembrne protein 1; OR, odds rtio. Tble V. Anlysis of the correltion between the genetic polymorphism of the TERT rs locus nd the progression of course of disese of the mle lung cncer ptients. Indexes of progression of course of disese Genotype I+II III+IV P-vlue OR (95% CI) CC CT ( ) TT ( ) CT+TT ( ) Lymphtic metstsis (-) Lymphtic metstsis (+) CC CT ( ) TT ( ) CT+TT ( ) One tumor More thn two tumors CC CT ( ) TT ( ) CT+TT ( ) The OR vlue ws subjected to ge correction. The differences were considered sttisticlly significnt t P<0.05. TERT, telomerse reverse trnscriptse; OR, odds rtio. Anlysis of the correltion between the genetic polymorphism of TERT nd CLPTM1L nd progression of lung cncer. The results in Tbles V nd VI show tht in lung cncer ptients, crrying the mutnt genotype (CT+TT) t the TERT rs locus is ssocited with the number of tumors (OR=0.553, 95% CI= ). The differences were sttisticlly significnt. The indexes relted to progression of other lung cncers (TNM stging nd lymphtic metstsis) were not correlted with the genetic polymorphism. Discussion The incidence of lung cncer is multi-fctor nd multi-stge process cused by genetic nd environmentl fctors (1). In recent yers, numerous studies hve focused on the
6 XIAO nd HE: GENETIC POLYMORPHISMS IN THE TERT-CLPTM1L REGION AND LUNG CANCER SUSCEPTIBILITY 1593 Tble VI. Anlysis of the correltion between the genetic polymorphism of the CLPTM1L rs locus nd the progression of the course of disese of mle lung cncer ptients. Indexes of progression of course of disese Genotype I+II III+IV P-vlue OR (95% CI) CC CT ( ) TT ( ) CT+TT ( ) Lymphtic metstsis ( ) Lymphtic metstsis (+) CC CT ( ) TT ( ) CT+TT ( ) One tumor More thn two tumors CC CT ( ) TT ( ) CT+TT ( ) The OR vlue ws subjected to ge correction. The differences were considered sttisticlly significnt t P<0.05. CLPTM1L, cleft lip nd plte trnsmembrne protein 1; OR, odds rtio. reltionship between relevnt genetic polymorphisms nd lung cncer susceptibility. Studying mles from Jinzhou city s reserch subjects, we investigted the reltionship between the risk of developing lung cncer nd polymorphisms of TERT nd CLPTM1L s well s exposure to risk fctors. Both SNPs t the TERT rs locus nd CLPTM1L rs locus cn increse the risk of developing lung cncer. The interctions between the two fctors nd genetic nd environmentl fctors significntly increse the risk of developing lung cncer. TERT is the ctlytic subunit of telomerse, nd is locted on chromosome 5p It spns 35 kb, nd comprises 16 exons nd 15 introns. It is rte-limiting fctor for synthesizing the telomerse holoenzyme. The rs locus is locted on the second exon of the gene. The moleculr weight of the TERT protein is pproximtely 127 kd, nd is primrily distributed in the nucleus. Muttion of its non-ctive structurl domin, DAT, influences the binding between TERT nd telomere DNA, thus ffecting the ctivity of telomerse in extending telomeres. Moreover, it hs higher tumor specificity (19). Our results showed tht there were significnt differences in genotype frequencies between the cse group nd control group. The risk of developing lung cncer in the popultion crrying the T llele is incresed significntly compred with the popultion crrying the C llele. The risk of developing lung cncer in the popultion crrying the mutnt genotype nd the CT genotype is incresed significntly compred with the popultion crrying the CC wild genotype. The differences were sttisticlly significnt. These results indicte tht genetic polymorphism of the TERT rs locus my be n independent risk fctor for the incidence of lung cncer in mles. CLPTM1L is locted on the chromosome 5p15.33 region, nd encodes for trnsmembrne protein. It cn induce cell poptosis in cispltin-resistnt cell lines. It is expressed in multiple norml nd mlignnt tissues such s the skin, lung, ovry, cervix, nd thymus (20,21). Currently, CLPTM1L is confirmed to be overexpressed nd resistnt to cispltin in humn ovrin tumor cell lines. Its overexpression in pulmonry tumor cells cn protect ginst poptosis induced by genotoxic stress (22-24), indicting tht it hs nti-poptotic function. However, the functions of CLPTM1L, nd its role in tumorigenesis remin uncler. We studied the reltionship between the genetic polymorphism of the CLPTM1L rs locus nd lung cncer in mles. The risk of developing lung cncer in the popultion crrying the T llele is incresed significntly compred with those crrying the C llele. Bsed on comprison between the combintion of the two mutnt genotypes (CT+TT) nd the wild homozygous genotype (CC), the mutnt genotype increses the risk of developing lung cncer. There is no reserch on the reltionship between the genetic polymorphism nd lung cncer, wheres gret del on lung cncer, but there re differences mong the results. This study hd limittions. The smple-size ws reltively smll. The nlysis only involved SNPs of two genes in the chromosome 5p15.33 region. Future studies require n expnded popultion rnge nd incresed smple-size. Furthermore, the nlysis should involve multiple genetic loci. The reltionship between genetic polymorphisms of the
7 1594 rs nd rs loci nd the progression of the disese requires further vlidtion in future studies. In conclusion, there is correltion between genetic polymorphisms of TERT nd CLPTM1L nd lung cncer in mles. The TERT rs nd CLPTMlL rs401681t lleles increse the risk of developing lung cncer in mles. They ply role in understnding the pthogenesis of lung cncer nd screening for the high-risk popultion. Acknowledgements The present study ws funded by Jinzhou Medicl University specil fund XZJJ References 1. Yin J, Li Y, Yin M, Sun J, Liu L, Qin Q, Li X, Long L, Nie S nd Wei S: TERT-CLPTM1L polymorphism rs contributes to cncers risk: evidence from met-nlysis bsed on 29 publictions. PLoS One 7: e50650, Mocellin S, Verdi D, Pooley KA, Lndi MT, Egn KM, Bird DM, Prescott J, De Vivo I nd Nitti D: Telomerse reverse trnscriptse locus polymorphisms nd cncer risk: field synopsis nd met-nlysis. J Ntl Cncer Inst 104: , Chen XF, Ci S, Chen QG, Ni ZH, Tng JH, Xu DW nd Wng XB: Multiple vrints of TERT nd CLPTM1L constitute risk fctors for lung denocrcinom. Genet Mol Res 11: , Jing M, Wu H nd Qin C: Genetic vrint rs t 5p15.33 modifies susceptibility to lung cncer but not esophgel squmous cell crcinom. PLoS One 8: e84277, Yng IA, Hollowy JW nd Fong KM: Genetic susceptibility to lung cncer nd co-morbidities. J Thorc Dis 5 (Suppl 5): , Zhong R, Liu L, Zou L, Zhu Y, Chen W, Zhu B, Shen N, Rui R, Long L, Ke J, et l: Genetic vritions in TERT-CLPTM1L locus re ssocited with risk of lung cncer in Chinese popultion. Mol Crcinog 52 (Suppl 1): E118-E126, Li C, Yin Z, Wu W, Li X, Ren Y nd Zhou B: Genetic vritions in TERT-CLPTM1L genes nd risk of lung cncer in Chinese women nonsmokers. PLoS One 8: e64988, Ln Q, Cwthon R, Go Y, Hu W, Hosgood HD III, Brone-Adesi F, Ji BT, Bssig B, Chow WH, Shu X, et l: Longer telomere length in peripherl white blood cells is ssocited with risk of lung cncer nd the rs (CLPTM1L-TERT) polymorphism in prospective cohort study mong women in Chin. PLoS One 8: e59230, Myneni AA, Chng SC, Niu R, Liu L, Ochs-Blcom HM, Li Y, Zhng C, Zho B, Shi J, Hn X, et l: Genetic polymorphisms of TERT nd CLPTM1L nd risk of lung cncer - cse-control study in Chinese popultion. Lung Cncer 80: , Zho Z, Li C, Yng L, Zhng X, Zho X, Song X, Li X, Wng J, Qin J, Yng Y, et l: Significnt ssocition of 5p15.33 (TERT CLPTM1L genes) with lung cncer in Chinese Hn popultion. Exp Lung Res 39: 91-98, Wng H, Zho Y, M J, Zhng G, Mu Y, Qi G, Fng Z, Wng L, Fn Q nd M Z: The genetic vrint rs401681c/t is ssocited with the risk of non-smll cell lung cncer in Chinese minlnd popultion. Genet Mol Res 12: 67-73, Tseng TS, Prk JY, Zblet J, Moody-Thoms S, Sothern MS, Chen T, Evns DE nd Lin HY: Role of nicotine dependence on the reltionship between vrints in the nicotinic receptor genes nd risk of lung denocrcinom. PLoS One 9: e107268, Yin Z, Cui Z, Ren Y, Zhng H, Yn Y, Zho Y, M R, Wng Q, He Q nd Zhou B: Genetic polymorphisms of TERT nd CLPTM1L, cooking oil fume exposure, nd risk of lung cncer: cse-control study in Chinese non-smoking femle popultion. Med Oncol 31: 114, Wng Z, Zhu B, Zhng M, Prikh H, Ji J, Chung CC, Smpson JN, Hoskins JW, Hutchinson A, Burdette L, et l: Imputtion nd subset-bsed ssocition nlysis cross different cncer types identifies multiple independent risk loci in the TERT-CLPTM1L region on chromosome 5p Hum Mol Genet 23: , Zhng Y, Zho M, Shen L, Ren Y, Su L, Li X, Yin Z nd Zhou B: Genetic polymorphisms of TERT nd CLPTM1L nd risk of lung cncer: cse-control study in northest Chinese mle popultion. Med Oncol 31: 18, Zho MM, Zhng Y, Shen L, Ren YW, Li XL, Yin ZH nd Zhou BS: Genetic vritions in TERT-CLPTM1L genes nd risk of lung cncer in Chinese popultion. Asin Pc J Cncer Prev 15: , Azd AK, Qiu X, Boyd K, Kung Q, Emmi M, Perer N, Plepu P, Ptel D, Chen Z, Cheng D, et l: A genetic sequence vrint (GSV) t susceptibility loci of 5p15.33 (TERT CLPTM1L) is ssocited with survivl outcome in loclly dvnced nd metsttic non smll-cell lung cncer (NSCLC). Lung Cncer 84: , Wu H nd Zhu R: Quntittive ssessment of common genetic vrints on chromosome 5p15 nd lung cncer risk. Tumour Biol 35: , Zhng C, Doherty JA, Burgess S, Hung RJ, Lindström S, Krft P, Gong J, Amos CI, Sellers TA, Monteiro AN, et l; GECCO nd GAME-ON Network: CORECT, DRIVE, ELLIPSE, FOCI, nd TRICL: Genetic determinnts of telomere length nd risk of common cncers: Mendelin rndomiztion study. Hum Mol Genet 24: , Liu SG, M L, Cen QH, Hung JS, Zhng JX nd Zhng JJ: Assocition of genetic polymorphisms in TERT-CLPTM1L with lung cncer in Chinese popultion. Genet Mol Res 14: , Rennert G, Kremer R, Rennert HS, Wollner M, Agbry A, Pinchev M, Lejbkowicz F, Spitz MR nd Musct JE: Lower lung cncer rtes in Jewish smokers in Isrel nd the USA. Int J Cncer 137: , Kocrnik JM, Prk SL, Hn J, Dumitrescu L, Cheng I, Wilkens LR, Schumcher FR, Kolonel L, Crlson CS, Crwford DC, et l: Pleiotropic nd sex-specific effects of cncer GWAS SNPs on melnom risk in the popultion rchitecture using genomics nd epidemiology (PAGE) study. PLoS One 10: e , Kchuri L, Ltifovic L, Liu G nd Hung RJ: Systemtic review of genetic vrition in chromosome 5p15.33 nd telomere length s predictive nd prognostic biomrkers for lung cncer. Cncer Epidemiol Biomrkers Prev 25: , Krmi S, Hn Y, Pnde M, Cheng I, Rudd J, Pierce BL, Nutter EL, Schumcher FR, Kote-Jri Z, Lindstrom S, et l; GECCO nd the GAME-ON Network: CORECT, DRIVE, ELLIPSE, FOCI, nd TRICL: Telomere structure nd mintennce gene vrints nd risk of five cncer types. Int J Cncer 139: , 2016.
CheckMate 153: Randomized Results of Continuous vs 1-Year Fixed-Duration Nivolumab in Patients With Advanced Non-Small Cell Lung Cancer
CheckMte 53: Rndomized Results of Continuous vs -Yer Fixed-Durtion Nivolumb in Ptients With Advnced Non-Smll Cell Lung Cncer Abstrct 297O Spigel DR, McCleod M, Hussein MA, Wterhouse DM, Einhorn L, Horn
More informationStudy on the association between PI3K/AKT/mTOR signaling pathway gene polymorphism and susceptibility to gastric
JBUON 2017; 22(6): 1488-1493 ISSN: 1107-0625, online ISSN: 2241-6293 www.jbuon.com E-mil: editoril_office@jbuon.com ORIGINAL ARTICLE Study on the ssocition between PI3K/AKT/mTOR signling pthwy gene polymorphism
More informationEfficacy of Pembrolizumab in Patients With Advanced Melanoma With Stable Brain Metastases at Baseline: A Pooled Retrospective Analysis
Efficcy of Pembrolizumb in Ptients With Advnced Melnom With Stble Brin Metstses t Bseline: A Pooled Retrospective Anlysis Abstrct 1248PD Hmid O, Ribs A, Dud A, Butler MO, Crlino MS, Hwu WJ, Long GV, Ancell
More informationRESEARCH ARTICLE. Wen Li 1, Jing Deng 2 *, Shuang-Shuang Wang 1, Liang Ma 1, Jiang Pei 1, Xiao-Xi Zeng 1, Jian-Xin Tang 1. Abstract.
DOI:http://dx.doi.org/10.7314/APJCP.2014.15.24.10937 Methyltion of the RAR-β Gene nd Cigrette Smoking in NSCLC in Southern-Centrl Chinese RESEARCH ARTICLE Assocition of Methyltion of the RAR-β Gene with
More informationA118G Polymorphism in l-opioid Receptor Gene and Interactions with Smoking and Drinking on Risk of Oesophageal Squamous Cell Carcinoma
Journl of Clinicl Lbortory Anlysis 31: e22018 (2017) A118G Polymorphism in l-opioid Receptor Gene nd Interctions with Smoking nd Drinking on Risk of Oesophgel Squmous Cell Crcinom Xinfng Xu,* Boneng Mo,
More informationClinical Study Report Synopsis Drug Substance Naloxegol Study Code D3820C00018 Edition Number 1 Date 01 February 2013 EudraCT Number
EudrCT Number 2012-001531-31 A Phse I, Rndomised, Open-lbel, 3-wy Cross-over Study in Helthy Volunteers to Demonstrte the Bioequivlence of the Nloxegol 25 mg Commercil nd Phse III Formultions nd to Assess
More informationEsophageal carcinoma is the eighth most common cancer
ORIGINAL ARTICLE Tumor-Strom Rtio Is n Independent Predictor for Survivl in Esophgel Squmous Cell Crcinom Ki Wng, MD,* Wei M, MD,* Jinbo Wng, MD,* Ling Yu, MD, Xiomei Zhng, MD, Zhenbo Wng, MD, Bingxu Tn,
More informationA cross-sectional and follow-up study of leukopenia in tuberculosis patients: prevalence, risk factors and impact of anti-tuberculosis
Originl Article A cross-sectionl nd follow-up study of leukopeni in tuberculosis ptients: prevlence, risk fctors nd impct of nti-tuberculosis tretment Fei-Shen Lin 1 *, Mei-Ying Wu 2 *, Wen-Jun Tu 3, Hong-Qiu
More informationAssociation between LAPTM4B gene polymorphism and susceptibility to and prognosis of diffuse large B cell lymphoma
264 Assocition between LAPTM4B gene polymorphism nd susceptibility to nd prognosis of diffuse lrge B cell lymphom HUIRONG DING 1*, XIAOJING CHENG 2*, NING DING 3*, ZHIHUA TIAN 1, JUN ZHU 3, CHUNLIAN ZHOU
More informationImpact of Positive Nodal Metastases in Patients with Thymic Carcinoma and Thymic Neuroendocrine Tumors
Originl Article Impct of Positive Nodl Metstses in Ptients with Thymic Crcinom nd Thymic Neuroendocrine Tumors Benny Weksler, MD, Anthony Holden, MD, nd Jennifer L. Sullivn, MD Introduction: Thymic crcinoms
More informationInvasive Pneumococcal Disease Quarterly Report. July September 2017
Invsive Pneumococcl Disese Qurterly Report July September 2017 Prepred s prt of Ministry of Helth contrct for scientific services by Rebekh Roos Helen Heffernn October 2017 Acknowledgements This report
More informationExtraction and Some Functional Properties of Protein Extract from Rice Bran
Ksetsrt J. (Nt. Sci.) 40 : 209-214 (2006) Extrction nd Some Functionl Properties of Protein Extrct from Rice Brn Chockchi Theerkulkit*, Siree Chiseri nd Siriwt Mongkolknchnsiri ABSTRACT Rice brn protein
More informationBody mass index, waist-to-hip ratio, and metabolic syndrome as predictors of middle-aged men's health
Originl Article - Sexul Dysfunction/Infertility pissn 2005-6737 eissn 2005-6745 Body mss index, wist-to-hip rtio, nd metbolic syndrome s predictors of middle-ged men's helth Jung Hyun Prk *, In-Chng Cho
More informationAssociation on polymorphisms in LncRNA HOTAIR and susceptibility to HNSCC in Chinese population
Europen Review for Medicl nd Phrmcologicl Sciences 2018; 22: 702-706 Assocition on polymorphisms in LncRNA HOTAIR nd susceptibility to HNSCC in Chinese popultion B. WU 1, J. LIU 2, B. WANG 2, X. LIAO 1,
More informationCopy Number ID2 MYCN ID2 MYCN. Copy Number MYCN DDX1 ID2 KIDINS220 MBOAT2 ID2
Copy Numer Copy Numer Copy Numer Copy Numer DIPG38 DIPG49 ID2 MYCN ID2 MYCN c DIPG01 d DIPG29 ID2 MYCN ID2 MYCN e STNG2 f MYCN DIPG01 Chr. 2 DIPG29 Chr. 1 MYCN DDX1 Chr. 2 ID2 KIDINS220 MBOAT2 ID2 Supplementry
More informationClinical statistics analysis on the characteristics of pneumoconiosis of Chinese miner population
Originl Article Clinicl sttistics nlysis on the chrcteristics of pneumoconiosis of Chinese miner popultion Mei-Fng Wng 1 *, Run-Ze Li 2 *, Ying Li 2, Xue-Qin Cheng 1, Jun Yng 1, Wen Chen 3, Xing-Xing Fn
More informationLung cancer is the leading cause of cancer death worldwide, EGFR Mutation and Brain Metastasis in Pulmonary Adenocarcinomas
Originl Article EGFR Muttion nd Brin Metstsis in Pulmonry Adenocrcinoms Dong-Yeop Shin, MD,* Im Il N, MD,* Cheol Hyeon Kim, MD, PhD, Sunhoo Prk, MD, PhD, HeeJong Bek, MD, PhD, nd Sung Hyun Yng, MD, PhD*
More informationJournal of Hainan Medical University.
132 Journl of Hinn Medicl University 2017; 23(11): 132-136 Journl of Hinn Medicl University http://www.hnykdxxb.com Assessment of the efficcy nd sfety of bronchil rtery perfusion chemotherpy combined with
More informationPrognostic significance of pretreatment serum levels of albumin, LDH and total bilirubin in patients with nonmetastatic
Crcinogenesis, 2015, Vol. 36, No. 2, 243 248 doi:10.1093/crcin/bgu247 Advnce Access publiction December 18, 2014 Originl Mnuscript originl mnuscript Prognostic significnce of pretretment serum levels of
More informationOriginal Article CD40-1C>T polymorphism and the risk of lung cancer in a Chinese population
Int J Clin Exp Pthol 2015;8(11):15163-15169 www.ijcep.com /ISSN:1936-2625/IJCEP0015790 Originl Article CD40-1C>T polymorphism nd the risk of lung cncer in Chinese popultion Gng Zhou 1*, Ying Wng 1,2*,
More informationENERGY CONTENT OF BARLEY
ENERGY CONTENT OF BARLEY VARIATION IN THE DIETARY ENERGY CONTENT OF BARLEY Shwn Firbirn, John Ptience, Hnk Clssen nd Ruurd Zijlstr SUMMARY Formultion of commercil pig diets requires n incresing degree
More information8/1/2017. Correlating Radiomics Information with Clinical Outcomes for Lung SBRT. Disclosure. Acknowledgements
Correlting Rdiomics Informtion with Clinicl Outcomes for Lung SBRT Fng-Fng Yin, PhD Duke University Medicl Center AAPM 2017 Denver CO Disclosure This reserch is prtilly funded by reserch grnt from Vrin
More informationOne of the most important biological mechanisms of
Brief Report Serum Thymidine Kinse 1 Activity in the Prognosis nd Monitoring of Chemotherpy in Lung Cncer Ptients: A Brief Report Benjmin Nismn, PhD,* Hovv Nechushtn, MD, PhD,* Him Birn, MD, Hds Gntz-Sorotsky,
More informationSignificance of Expression of TGF- in Pulmonary Metastasis in Non-small Cell Lung Cancer Tissues
Originl Article Significnce of Expression of in Pulmonry Metstsis in Non-smll Cell Lung Cncer Tissues Hisshi Sji, Hruhiko Nkmur, Idiris Awut, Norihito Kwski, Msru Hgiwr, Akihiko Ogt, Mkoto Hosk, Tkmoto
More informationInput from external experts and manufacturer on the 2 nd draft project plan Stool DNA testing for early detection of colorectal cancer
Input externl experts nd mnufcturer on the 2 nd drft project pln Stool DNA testing for erly detection of colorectl cncer (Project ID:OTJA10) All s nd uthor s replies on the 2nd drft project pln Stool DNA
More informationEffects of blueberries on migration, invasion, proliferation, the cell cycle and apoptosis in hepatocellular carcinoma cells
BIOMEDICAL REPORTS 5: 579-584, 2016 Effects of blueberries on migrtion, invsion, prolifertion, the cell cycle nd poptosis in heptocellulr crcinom cells WEI ZHAN 1*, XIN LIAO 2*, LEI YU 3, TIAN TIAN 3,
More informationThe potential future of targeted radionuclide therapy: implications for occupational exposure? P. Covens
The potentil future of trgeted rdionuclide therpy: implictions for occuptionl exposure? Introduction: Trgeted Rdionuclide Therpy (TRT) Systemic tretment Molecule lbelled with rdionuclide delivers toxic
More informationIntroduction. These patients benefit less from conventional chemotherapy than patients identified as MMR proficient or microsatellite stable 3-5
Nivolumb + Ipilimumb Combintion in Ptients With DNA Mismtch Repir-Deficient/Microstellite Instbility-High Metsttic Colorectl Cncer: First Report of the Full Cohort From CheckMte-142 Abstrct 553 André T,
More informationAssessment of Depression in Multiple Sclerosis. Validity of Including Somatic Items on the Beck Depression Inventory II
Assessment of Depression in Multiple Sclerosis Vlidity of Including Somtic Items on the Beck Depression Inventory II Peggy Crwford, PhD; Noh J. Webster, MA Signs nd symptoms of multiple sclerosis (MS)
More informationHuman leukocyte antigen-drb1 polymorphism in childhood acute lymphoblastic leukemia
MOLECULAR AND CLINICAL ONCOLOGY 3: 425-429, 2015 Humn leukocyte ntigen-drb1 polymorphism in childhood cute lymphoblstic leukemi MERVAT M. EL ANSARY 1, LAMIAA A. MOHAMMED 2, TAMER H. HASSAN 3, AHMED BARAKA
More informationEvaluation of the detection of 14 high-risk human papillomaviruses with HPV 16 and HPV 18 genotyping for cervical cancer screening
1332 Evlution of the detection of 14 high-risk humn ppillomviruses with HPV 16 nd HPV 18 genotyping for cervicl cncer screening MEI-LU BIAN, JIAO-YING CHENG, LI MA, XIAO CONG, JUN LIU, YING CHEN nd XI
More informationA Comparison of Serum Magnesium Level in Pregnant Women with and without Gestational Diabetes Mellitus (GDM)
Brief Report J Bbol Univ Med Sci Vol 18, Issu 12; Dec 2016. P:71-75 A Comprison of Serum Mgnesium Level in Pregnnt Women with nd without Gesttionl Dibetes Mellitus (GDM) Z. Bouzri (MD) 1, F. Elmi(MD) 2,
More informationGeographical influence on digit ratio (2D:4D): a case study of Andoni and Ikwerre ethnic groups in Niger delta, Nigeria.
Journl of Applied Biosciences 27: 1736-1741 ISSN 1997 5902 Geogrphicl influence on digit rtio (2D:4D): cse study of Andoni nd Ikwerre ethnic groups in Niger delt, Nigeri. Gwunirem, Isrel U 1 nd Ihemelndu,
More informationSYNOPSIS Final Abbreviated Clinical Study Report for Study CA ABBREVIATED REPORT
Finl Arevited Clinicl Study Report Nme of Sponsor/Compny: Bristol-Myers Squi Ipilimum Individul Study Tle Referring to the Dossier (For Ntionl Authority Use Only) Nme of Finished Product: Yervoy Nme of
More informationSupplementary Online Content
Supplementry Online Content Zulmn DM, Pl Chee C, Ezeji-Okoye SC, et l. Effect of n intensive outptient progrm to ugment primry cre for high-need Veterns Affirs ptients: rndomized clinicl tril. JAMA Intern
More informationPaper-based skin patch for the diagnostic screening of cystic fibrosis
Electronic Supplementry Mteril (ESI) for ChemComm. This journl is The Royl Society of Chemistry 2015 Supplementry informtion Pper-bsed skin ptch for the dignostic screening of cystic fibrosis Xun Mu,*
More informationRheumatoid-susceptible alleles of HLA-DRB 1 are genetically recessive to non-susceptible alleles in the progression of bone destruction in the wrists
Annls of the Rheumtic Diseses 1994; 53: 587-592 587 Deprtment of Orthopedic Surgery, Knsi Medicl University, Otokoym Hospitl, Kyoto, Jpn Y Tod Y Mori Deprtment of Orthopedic Surgery, Knsi Medicl University,
More informationOriginal Article Serum tumor markers used for predicting esophagogastric junction adenocarcinoma in esophageal malignancy
Int J Clin Exp Med 2016;9(6):11859-11864 www.ijcem.com /ISSN:1940-5901/IJCEM0025330 Originl Article Serum tumor mrkers used for predicting esophgogstric junction denocrcinom in esophgel mlignncy Yongkng
More informationAssociation of PTEN expression with liver function and inflammatory changes in patients with liver cancer after chemotherapy
ONCOLOGY LETTERS Assocition of PTEN expression with liver function nd inflmmtory chnges in ptients with liver cncer fter chemotherpy JIXIANG ZHOU nd XIAOLI LI Deprtment of Heptobiliry Surgery, Xingy Hospitl,
More informationAnalysis of detection results of thyroid function-related indexes in pregnant women and establishment of the reference interval
EXPERIMENTAL AND THERAPEUTIC MEDICINE Anlysis of detection results of thyroid function-relted indexes in pregnnt women nd estblishment of the reference intervl QI ZHOU 1*, YANLI ZHANG 1*, JIANHUA ZHOU
More informationUsing Paclobutrazol to Suppress Inflorescence Height of Potted Phalaenopsis Orchids
Using Pcloutrzol to Suppress Inflorescence Height of Potted Phlenopsis Orchids A REPORT SUBMITTED TO FINE AMERICAS Linsey Newton nd Erik Runkle Deprtment of Horticulture Spring 28 Using Pcloutrzol to Suppress
More informationThe Effects of Small Sized Rice Bowl on Carbohydrate Intake and Dietary Patterns in Women with Type 2 Diabetes
Originl Article doi: 10.4093/kdj.2010.34.3.166 pissn 1976-9180 eissn 2093-2650 The Effects of Smll Sized Rice Bowl on Crbohydrte Intke nd Dietry Ptterns in Women with Type 2 Dibetes Hee-Jung Ahn 1, *,
More informationAnalysis of Regulatory of Interrelated Activity of Hepatocyte and Hepatitis B Viruses
Interntionl Journl of Biomedicl Mterils Reserch 8 6(): -7 http://www.sciencepublishinggroup.com/j/ijbmr doi:.648/j.ijbmr.86. ISSN: 33-756 (Print) ISSN: 33-7579 (Online) Anlysis of Regultory of Interrelted
More informationPNEUMOVAX 23 is recommended by the CDC for all your appropriate adult patients at increased risk for pneumococcal disease 1,2 :
PNEUMOVAX 23 is recommended y the CDC for ll your pproprite dult ptients t incresed risk for pneumococcl disese 1,2 : Adults ged
More informationAnalysis of Risk Factors for the Development of Incisional and Parastomal Hernias in Patients after Colorectal Surgery
Originl Article Journl of the Koren Society of J Koren Soc Coloproctol 2012;28(6):299-303 http://dx.doi.org/10.3393/jksc.2012.28.6.299 pissn 2093-7822 eissn 2093-7830 Anlysis of Risk Fctors for the Development
More informationEpidemiological survey and analysis of asthma in children aged 0-14 years old in urban and rural areas of Chengdu region
Originl Article Epidemiologicl survey nd nlysis of sthm in children ged 0-14 yers old in urbn nd rurl res of Chengdu region Min Li 1, Qiong Zhng 2, Wei-Jun Shi 2, Ln Li 1, Yn Li 2, Ying Png 1, Bin Yo 1,
More informationJournal of Hainan Medical University 2017; 23(2): Journal of Hainan Medical University.
Journl of Hinn Medicl University 2017; 23(2): 151-155 151 Journl of Hinn Medicl University http://www.hnykdxxb.com Reltionship between DEXA bone minerl density mesurement results nd serum cytokines s well
More informationFeeding state and age dependent changes in melaninconcentrating hormone expression in the hypothalamus of broiler chickens
Supplementry Mterils Epub: No 2017_23 Vol. 65, 2018 https://doi.org/10.183/bp.2017_23 Regulr pper Feeding stte nd ge dependent chnges in melninconcentrting hormone expression in the hypothlmus of broiler
More informationOriginal Article Prognostic and clinicopathologic significance of AEG-1/MTDH and E-cadherin expression in human gallbladder carcinoma
Int J Clin Exp Pthol 2018;11(12):6025-6031 www.ijcep.com /ISSN:1936-2625/IJCEP0086349 Originl Article Prognostic nd clinicopthologic significnce of AEG-1/MTDH nd E-cdherin expression in humn gllbldder
More informationCHEST. Thyroid transcription factor 1 (TTF-1) is an important. Original Research
CHEST Originl Reserch Clinicl Significnce of Thyroid Trnscription Fctor-1 in Advnced Lung Adenocrcinom Under Epiderml Growth Fctor Receptor Tyrosine Kinse Inhibitor Tretment Kuei-Pin Chung, MD; Yen-Tsung
More informationRisk of Colorectal Cancer by Subsite in a Swedish Prostate Cancer Cohort
Specil Report Risk of Colorectl Cncer by Subsite in Swedish Prostte Cncer Cohort Yunxi Lu, MD, PhD, Rickrd Ljung, MD, PhD, Ann Mrtling, MD, PhD, nd Mts Lindbld, MD, PhD Bckground: The reltionship between
More informationCommunity. Profile Powell County. Public Health and Safety Division
Community Helth Profile 2015 Powell County Public Helth nd Sfety Division Tble of Contents Demogrphic Informtion 1 Communicble Disese 3 Chronic Disese 4 Mternl nd Child Helth 10 Mortlity 12 Behviorl Risk
More informationCommunity. Profile Yellowstone County. Public Health and Safety Division
Community Helth Profile 2015 Yellowstone County Public Helth nd Sfety Division Tble of Contents Demogrphic Informtion 1 Communicble Disese 3 Chronic Disese 4 Mternl nd Child Helth 10 Mortlity 12 Behviorl
More informationInhaled Corticosteroid Is Associated With an Increased Risk of TB in Patients With COPD
CHEST Originl Reserch Inhled Corticosteroid Is Associted With n Incresed Risk of TB in Ptients With COPD Jung-Hyun Kim, MD ; Ji-Soo Prk, MD ; Kyung-Ho Kim, MD ; Hye-Cheol Jeong, MD ; Eun-Kyung Kim, MD
More informationCommunity. Profile Lewis & Clark County. Public Health and Safety Division
Community Helth Profile 2015 Lewis & Clrk County Public Helth nd Sfety Division Tble of Contents Demogrphic Informtion 1 Communicble Disese 3 Chronic Disese 4 Mternl nd Child Helth 10 Mortlity 12 Behviorl
More informationCommunity. Profile Missoula County. Public Health and Safety Division
Community Helth Profile 2015 Missoul County Public Helth nd Sfety Division Tble of Contents Demogrphic Informtion 1 Communicble Disese 3 Chronic Disese 4 Mternl nd Child Helth 10 Mortlity 12 Behviorl Risk
More informationA review of the patterns of docetaxel use for hormone-resistant prostate cancer at the Princess Margaret Hospital
MEDICAL ONCOLOGY A review of the ptterns of docetxel use for hormone-resistnt prostte cncer t the Princess Mrgret Hospitl S.N. Chin MD,* L. Wng MSc, M. Moore MD,* nd S.S. Sridhr MD MSc* ABSTRACT Bckground
More informationphosphatase isoenzyme activity: estimation of
J Clin Pthol 1988;41:202-206 Quntittive method for determining serum lkline phosphtse isoenzyme ctivity: estimtion of intestinl component M J PEAKE, M PEJAKOVIC, G H WHITE From the Deprtment ofbiochemistry
More informationOpioid Use and Survival at the End of Life: A Survey of a Hospice Population
532 Journl of Pin nd Symptom Mngement Vol. 32 No. 6 December 2006 NHPCO Originl Article Opioid Use nd Survivl t the End of Life: A Survey of Hospice Popultion Russell K. Portenoy, MD, Un Sibircev, BA,
More informationComparison of three simple methods for the
J. clin. Pth. (1967), 2, 5 Comprison of three simple methods for the ssessment of 'free' thyroid hormone T. M. D. GIMLETTE1 From the Rdio-Isotope Lbortory, St. Thoms's Hospitl, London SYNOPSIS A dilysis
More informationEvaluation of the TEST 1 erythrocyte sedimentation rate system and intra- and inter-laboratory quality control using new latex control materials
Clin Chem Lb Med 2010;48(7):1043 1048 2010 by Wlter de Gruyter Berlin New York. DOI 10.1515/CCLM.2010.162 Evlution of the TEST 1 erythrocyte sedimenttion rte system nd intr- nd inter-lbortory qulity control
More informationCommunity. Profile Big Horn County. Public Health and Safety Division
Community Helth Profile 2015 Big Horn County Public Helth nd Sfety Division Tble of Contents Demogrphic Informtion 1 Communicble Disese 3 Chronic Disese 4 Mternl nd Child Helth 10 Mortlity 12 Behviorl
More informationComparative effectiveness of the tumour diagnostics,
Gut, 1987, 28, 323-329 Comprtive effectiveness of the tumour dignostics, C 19-9, C 125 nd crcinoembryonic ntigen in ptients with diseses of the digestive system K SKMOTO, Y HG, R YOSHIMR, H GMI, Y YOKOYM,
More informationCommunity. Profile Anaconda- Deer Lodge County. Public Health and Safety Division
Community Helth Profile 2015 Ancond- Deer Lodge County Public Helth nd Sfety Division Tble of Contents Demogrphic Informtion 1 Communicble Disese 3 Chronic Disese 4 Mternl nd Child Helth 10 Mortlity 12
More informationRecall Bias in Childhood Atopic Diseases Among Adults in The Odense Adolescence Cohort Study
Syddnsk Universitet Recll Bis in Childhood Atopic Diseses Among Adults in The Odense Adolescence Cohort Study Mørtz, Chrlotte G; Andersen, Klus Ejner; Bindslev-Jensen, Crsten Published in: Act Dermto-Venereologic
More informationFat intake in patients newly diagnosed with type 2 diabetes: a 4-year follow-up study in general practice
Originl ppers Ft intke in ptients newly dignosed with type 2 dibetes: 4-yer follow-up study in generl prctice Floris A vn de Lr, Eloy H vn de Lisdonk, Peter L B J Lucssen, J M H Tigchelr, Sski Meyboom,
More information27 June Bmnly L. WALTER ET AL.: RESPONSE OF CERVICAL CANCERS TO IRRADIATION
27 June 1964 Bmnly MEDICAL JOURNAL L. WALTER ET AL.: RESPONSE OF CERVICAL CANCERS TO IRRADIATION x 1,638.) FIG. 2.-Foci of sme tumour s in Fig. 1 contining vible tumour cells with scnty cytoplsm, reltively
More informationAbstract. Background. Aim. Patients and Methods. Patients. Study Design
Impct of the Use of Drugs nd Substitution Tretments on the Antivirl Tretment of Chronic Heptitis C: Anlysis of Complince, Virologicl Response nd Qulity of Life (CHEOBS). Melin, 1 J.-. Lng, D. Ouzn, 3 M.
More informationEstimating the impact of the 2009 influenza A(H1N1) pandemic on mortality in the elderly in Navarre, Spain
Rpid communictions Estimting the impct of the influenz pndemic on mortlity in the elderly in Nvrre, Spin J Cstill (jcstilc@nvrr.es) 1, J Etxeberri 1, E Ardnz 1, Y Floristán 1, R López Escudero 1, M Guevr
More informationEFFECTS OF AN ACUTE ENTERIC DISEASE CHALLENGE ON IGF-1 AND IGFBP-3 GENE EXPRESSION IN PORCINE SKELETAL MUSCLE
Swine Dy 22 Contents EFFECTS OF AN ACUTE ENTERIC DISEASE CHALLENGE ON IGF-1 AND IGFBP-3 GENE EXPRESSION IN PORCINE SKELETAL MUSCLE B. J. Johnson, J. P. Kyser, J. D. Dunn, A. T. Wyln, S. S. Dritz 1, J.
More informationEffects of physical exercise on working memory and prefrontal cortex function in post-stroke patients
Effects of physicl exercise on working memory nd prefrontl cortex function in post-stroke ptients M Moriy, C Aoki, K Sktni Grdute School of Helth Sciences Reserch, Mjor of Physicl Therpy, TeikyoHeisei
More informationUtilization of dental services in Southern China. Lo, ECM; Lin, HC; Wang, ZJ; Wong, MCM; Schwarz, E
Title Utiliztion of dentl services in Southern Chin Author(s) Lo, ECM; Lin, HC; Wng, ZJ; Wong, MCM; Schwrz, E Cittion Journl Of Dentl Reserch, 2001, v. 80 n. 5, p. 1471-1474 Issued Dte 2001 URL http://hdl.hndle.net/10722/53200
More informationCME/SAM. Study on Hyperuricemia in HBV-Associated Glomerulonephritis
AJCP / Originl Article Study on Hyperuricemi in HBV-Associted Glomerulonephritis Yongze Zhung, MD, PhD, 1 Yingho Yu, MD, PhD, 2 Yingfng Hung, MD, 3 nd Xiorong Zhong, MD 1 From the 1 Deprtment of Nephrology,
More informationClassic Papillary Thyroid Carcinoma with Tall Cell Features and Tall Cell Variant Have Similar Clinicopathologic Features
The Koren Journl of Pthology 2014; 48: 201-208 ORIGINAL ARTICLE Clssic Ppillry Thyroid Crcinom with Tll Cell Fetures nd Tll Cell Vrint Hve Similr Clinicopthologic Fetures Woo Jin Oh 1 Young Sub Lee 1 Uiju
More informationHypertension, hyperinsulinaemia and obesity in middle-aged Finns with impaired glucose tolerance
Journl of Humn Hypertension (1998) 12, 265 269 1998 Stockton Press. All rights reserved 0950-9240/98 $12.00 ORIGINAL ARTICLE Hypertension, hyperinsulinemi nd obesity in middle-ged Finns with impired glucose
More informationMETHOD 4010 SCREENING FOR PENTACHLOROPHENOL BY IMMUNOASSAY
METHOD 4010 SCREENING FOR PENTACHLOROPHENOL BY IMMUNOASSAY 1.0 SCOPE AND APPLICATION 1.1 Method 4010 is procedure for screening solids such s soils, sludges, nd queous medi such s wste wter nd lechtes
More informationXII. HIV/AIDS. Knowledge about HIV Transmission and Misconceptions about HIV
XII. HIV/AIDS Knowledge bout HIV Trnsmission nd Misconceptions bout HIV One of the most importnt prerequisites for reducing the rte of HIV infection is ccurte knowledge of how HIV is trnsmitted nd strtegies
More informationAnalysis of alternatives for insulinizing patients to achieve glycemic control and avoid accompanying risks of hypoglycemia
284 Anlysis of lterntives for izing ptients to chieve glycemic control nd void ccompnying risks of hypoglycemi JIALIN GAO 1,2*, QIANYIN XIONG 1,2*, JUN MIAO 1*, YAO ZHANG 2,3, LIBING XIA 1, MEIQIN LU 1,
More informationA FACTORIAL STUDY ON THE EFFECTS OF β CYCLODEXTRIN AND POLOXAMER 407 ON THE SOLUBILITY AND DISSOLUTION RATE OF PIROXICAM
IJRPC 20, (3) Chowdry et l. ISSN: 223 278 INTERNATIONAL JOURNAL OF RESEARCH IN PHARMACY AND CHEMISTRY Aville online t www.ijrpc.com Reserch Article A FACTORIAL STUDY ON THE EFFECTS OF β CYCLODEXTRIN AND
More informationCommunity. Profile Carter County. Public Health and Safety Division
Community Helth Profile 2015 Crter County Public Helth nd Sfety Division Tble of Contents Demogrphic Informtion 1 Communicble Disese 3 Chronic Disese 4 Mternl nd Child Helth 10 Mortlity 12 Behviorl Risk
More informationBlood pressure and diurnal variation in sodium, potassium, and water excretion
Journl of Humn Hypertension (1998) 12, 363 371 1998 Stockton Press. All rights reserved 0950-9240/98 $12.00 http://www.stockton-press.co.uk/jhh ORIGINAL ARTICLE Blood pressure nd diurnl vrition in sodium,
More informationDoes increasing physical activity reduce the excess risk of work disability among overweight individuals? 1
1 Does incresing physicl ctivity reduce the excess risk of work disbility mong overweight individuls? 1 by Jenni Ervsti, PhD, 2 Jkko Airksinen, PhD, Jn Pentti, MSc, Jussi Vhter, MD, PhD, Skri Suominen,
More informationEffect of vitamin D on the recurrence rate of rheumatoid arthritis
1812 Effect of vitmin D on the recurrence rte of rheumtoid rthritis JUNXIA YANG 1, LIN LIU 1, QINGLIN ZHANG 2, MEIRONG LI 1 nd JINGYA WANG 1 1 Deprtment of Rheumtology, 2 Centrl Lbortory, Xuzhou Centrl
More informationMOLECULAR AND CLINICAL ONCOLOGY 7: , 2017
MOLECULAR AND CLINICAL ONCOLOGY 7: 787-797, 2017 Evlution of epiderml growth fctor receptor serum levels nd their ssocition with clinicopthologicl chrcteristics in ptients with colorectl cncer MEHMET KARABULUT
More informationNutritional Epidemiology of Cancer in Korea: Recent Accomplishments and Future Directions
Nutritionl Epidemiology of Cncer in Kore RESEARCH COMMUNICATION Nutritionl Epidemiology of Cncer in Kore: Recent Accomplishments nd Future Directions He Dong Woo, Jeongseon Kim* Abstrct Becuse diet is
More informationUrinary Tract Infection in Men
C H A P T E R 1 9 Urinry Trct Infection in Men Toms L. Griebling, MD Associte Professor & Vice Chir of Urology University of Knss Knss City, Knss Contents INTRODUCTION........................................623
More informationHigh EGFR mrna expression is a prognostic factor for reduced survival in pancreatic cancer after gemcitabine-based adjuvant chemotherapy
INTERNATIONAL JOURNAL OF ONCOLOGY 38: 629-641, 2011 High EGFR mrna expression is prognostic fctor for reduced survivl in pncretic cncer fter gemcitbine-bsed djuvnt chemotherpy Hyto Fujit 1, Kenoki Ohuchid
More informationCorrelation between CT features and liver function and p53 expression in hepatitis, cirrhosis and hepatocellular carcinoma
ONCOLOGY LETTERS Correltion between CT fetures nd liver function nd p53 expression in heptitis, cirrhosis nd heptocellulr crcinom YAHUI HU, JING WU, SHA LI nd XIAOXIAO ZHAO Deprtment of Nucler Medicine,
More informationSTATISTICAL DATA ANALYSIS IN EXCEL
Microrry Center STATISTICAL DATA ANALYSIS IN EXCEL Prt 1 Introduction to Sttistics Dr. Petr Nzrov 14-06-2010 petr.nzrov@crp-snte.lu Sttisticl dt nlysis in Excel COURSE OVERVIEW Objectives The course: Reminds
More informationClinical manifestations in patients with alpha-fetoprotein producing gastric cancer
Curr Oncol, Vol. 21, pp. e394-399; doi: http://dx.doi.org/10.3747/co.21.1768 CLINICAL MANIFESTATIONS IN AFP PRODUCING GASTRIC CANCER ORIGINAL ARTICLE Clinicl mnifesttions in ptients with lph-fetoprotein
More informationHealth-Related Quality of Life and Symptoms of Depression in Extremely Obese Persons Seeking Bariatric Surgery
Oesity Surgery, 15, 3-39 Helth-Relted Qulity of Life nd Symptoms of Depression in Extremely Oese Persons Seeking Britric Surgery Anthony N. Frictore, PhD; Thoms A. Wdden, PhD; Dvid B. Srwer, PhD; Myles
More informationOriginal Article. T Akter 1, N Islam 2, MA Hoque 3, S Khanam 4, HA khan 5, BK Saha 6. Abstract:
Fridpur Med. Coll. J. 214;9(2):61-67 Originl Article Nebuliztion by Isotonic Mgnesium Sulphte Solution with Provide Erly nd Better Response s Compred to Conventionl Approch ( Plus Norml Sline) in Acute
More informationDose-dependent effect of daptomycin on the artificial prolongation of prothrombin time in coagulation abnormalities: in vitro verification
Hshimoto et l. BMC Phrmcology nd Toxicology (2017) 18:74 DOI 10.1186/s40360-017-0180-3 RESEARCH ARTICLE Open Access Dose-dependent effect of dptomycin on the rtificil prolongtion of prothrombin time in
More informationRESEARCH ARTICLE. Abstract. Introduction
DOI:http://dx.doi.org/10.7314/APJCP.2015.16.11.4699 Occuptionl Rdition Exposure nd Brest nd Esophgus Cnce Ris RESEARCH ARTICLE Nested Cse-control Study of Occuptionl Rdition Exposure nd Brest nd Esophgus
More informationImpact of Pharmacist Intervention on Diabetes Patients in an Ambulatory Setting
Impct of Phrmcist Intervention on Dibetes Ptients in n Ambultory Setting Julie Stding, PhrmD, CDE, Jmie Herrmnn, PhrmD, Ryn Wlters, MS, Chris Destche, PhrmD, nd Aln Chock, PhrmD Dibetes is the seventh-leding
More informationScientific research on the biological value of olive oil
Scientific reserch on the biologicl vlue olive oil Cov F.G. Ally M. (ed.). L' économie de l' olivier Pr : CIHEAM Options Méditerrnéennes : Série Etudes; n. 1988-V 1988 pges 149-152 Article vilble on le
More informationA genetic variant in ERCC2 is associated with gastric cancer prognosis in a Chinese population
Mutgenesis vol. 28 no. 4 pp. 441 446 Advnce Access puliction 16 My 2013 doi:10.1093/mutge/get023 A genetic vrint in ERCC2 is ssocited with gstric cncer prognosis in Chinese popultion Hiyn Chu 1,2,, Dongying
More informationUniversity of Texas Health Science Center, San Antonio, San Antonio, Texas, USA
Lung Cncer Chemotherpy Given Ner the End of Life by Community Oncologists for Advnced Non-Smll Cell Lung Cncer Jose R. Murillo, Jr., Jim Koeller b,c Methodist Hospitl, Houston, Texs, USA; b University
More information