Florida Oncology Symposium:

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1 2nd ANNUAL Florida Oncology Symposium: Clinical Pathways to Personalized Medicine The Ritz-Carlton Hotel Naples, Florida

2 Florida Oncology Symposium: Clinical Pathways to Personalized Medicine The Ritz-Carlton Hotel Naples, Florida COURSE DESCRIPTION Our second symposium offers learning opportunities and networking for those clinicians wanting to learn more about the latest clinical research applications to patient care in the diagnosis and management of various cancers: Hematology, Genitourinary Cancers, Melanoma, HPV and Sarcoma. In addition, an update on the progress of Moffitt s newly developed clinical pathways will be offered as a concurrent breakout session. These pathways have been developed to assist and to improve clinical outcomes in these disease sites: breast, prostate, lung, acute leukemia, sarcoma and pancreas. The objective is to catalyze clinician consensus and to reduce clinician variation toward the best possible outcome given a patient s unique clinical factors, genetics, and personal preferences. These pathways are primarily designed to support the administration of therapies proven to optimize efficacy and reduce toxicity, and secondarily to manage cost when prudent choices between clinically similar alternatives can drive more affordable, quality care. We are proud to share the early progress toward clinical pathways development with the conference participants to achieve an even better product by incorporating related feedback and collaboration. TARGET AUDIENCE This educational activity is planned to meet the educational needs of clinical and surgical oncologists in both academia and private practice. Primary care physicians and nurses in oncology will benefit from the presentations and small group discussions in the latest cancer treatment modalities. PROGRAM OBJECTIVES Upon completion of this program, participants should be able to: Discuss circulating tumor cells and how they can serve as a new platform to provide personalized medicine. To tailor therapies for chronic leukemias. Understand how HPV vaccination can be used to prevent different cancers in both women and men. Assess the current role of robotic cystectomy in the management of localized bladder cancer. Evaluate management options for prostate, bladder and kidney cancer. Describe new drugs and targets that are important in early phase clinical trials. Discuss the diagnosis and treatment of GIST, soft tissue and bone sarcomas. Recognize how clinical pathways use a patient s genetic signature to formulate personalized therapy. Recognize the benefits of immunotherapy for melanoma and hematologic malignancies. ACCREDITATION Physicians USF Health is accredited by the Accreditation Council for Continuing Medical Education to provide continuing medical education for physicians. USF Health designates this educational activity for a maximum of AMA PRA Category 1 Credits. Physicians should only claim credit commensurate with the extent of their participation in the activity. Nurses The University of South Florida College of Nursing is accredited as a provider of continuing nursing education by the American Nurses Credentialing Center s Commission on Accreditation. A maximum of contact hours may be earned by learners who successfully complete this continuing nursing education activity.

3 AGENDA MAY 5, 2011 THURSDAY 11:00 am 7:00 pm Registration 12:45 1:00 pm Welcome and Introduction Daniel Sullivan, MD 1:00 3:00 pm Personalized Medicine: New and Exciting Molecular Platforms Chairperson: Timothy Yeatman, MD, FACS Circulating Tumor Cells as a Guide to Personalized Medicine in Cancer David Nelson, PhD Integrating Biomarkers into Colorectal Cancer Clinical Trials Scott Kopetz, MD, PhD The Next Generation of Translational Oncology Levi Garraway, MD, PhD 3:00 3:15 pm Break 3:15 5:15 pm Molecular Determinants of Response in Clinical Oncology Microarrays for Diagnosis, Prognosis and Treatment Planning of Breast Cancer Stefan Glück, MD, PhD, FRCPC Biomarkers That Determine Response in Multiple Myeloma and Non-Hodgkin s Lymphoma Steven Grant, MD Biomarker-Driven Trials in Ovarian Cancer Johnathan Lancaster, MD, PhD Bio-marker Driven Trials in NSCLC Scott Antonia, MD, PhD 7:00 9:00 pm Dinner with Keynote speaker Molecular Signatures for Guiding Therapies of Non-Small Cell Lung Cancer David Carbone, MD, PhD MAY 6, 2011 FRIDAY 7:00 7:55 am Breakfast and Exhibits 7:55 8:00 am Welcome and Introduction Alan List, MD, Course Director 8:00-10:00 am SESSION 1: Hematology/Oncology Chairperson: Eduardo Sotomayor, MD AML in the Elderly: New Therapies Jeffrey Lancet, MD Consolidation therapy in AML: Should we transplant everyone? Hugo Fernandez, MD Targeted Therapies for Chronic Leukemias Javier Pinilla-Ibarz, MD, PhD Radioimmunotherapy for Hematologic Malignancies Michael Tomblyn, MD 10:00 10:30 am Break and Exhibits 10:30 11:30 am SESSION 2: Prevention of HPV Related Cancers: Current Practice and Future Horizons Chairperson: Dana Rollison, PhD Cancer Prevention through HPV Vaccination in Men and Women Kevin Collins, MD Cutaneous HPV and Non-Melanoma Skin Cancer Dana Rollison, PhD 11:30 am 12:45 pm Luncheon with Keynote Speaker Quality, Measurement and Economics of Health Care Systems Lisa Slama, PhD 12:45 2:30 pm SESSION 3: Genitourinary Cancers Chairperson: Julio Pow-Sang, MD Active Surveillance and Surgical Options for Localized Prostate Cancer Julio Pow-Sang, MD Radiation Therapy Options for Localized Prostate Cancer - Richard Wilder, MD (FRIDAY CONTINUED) Treatment Options for Hormone Refractory Prostate Cancer Jingsong Zhang, MD, PhD Management Options for Small Renal Tumors Philippe Spiess, MD Emerging Role of Robotic Cystectomy in the Management of Invasive Bladder Cancer Wade Sexton, MD 2:30-4:30 pm SESSION 4: Moffitt Pathways Chairperson: Robert Wenham, MD 2:30 3:00 pm Pathways to Improving Clinical Outcomes Mark Schippits, MD 3:00-3:30 pm Break and Exhibits 3:30 4:00 pm Break Out Sessions (select one) Breast Hatem Soliman, MD Prostate Mayer Fishman, MD, PhD and J. Zhang, MD, PhD Lung Mary Pinder, MD Acute Leukemia Jeffrey Lancet, MD Sarcoma Damon Reed, MD Pancreatic Gregory Springett, MD, PhD 4:00 4:30 pm Break Out Sessions Repeated (select one) Breast Hatem Soliman, MD Prostate Mayer Fishman, MD, PhD and J. Zhang, MD, PhD Lung Mary Pinder, MD Acute Leukemia Jeffrey Lancet, MD Sarcoma Damon Reed, MD Pancreatic Gregory Springett, MD, PhD Evening on Your Own MAY 7, 2011 SATURDAY 7:00 8:00 am Breakfast 8:00 9:30 am SESSION 5: Advances in the Treatment of Metastatic Melanoma Chairperson: Jeffrey Weber, MD, PhD INTRODUCTION: Melanoma: Poster Child for Novel and Targeted Therapies Jeffrey Weber, MD, PhD Regional Treatment for Melanoma: Liver or Limb? Jonathan Zager, MD Targeted Therapy for Melanoma is Here At Last Ragini Kudchadkar, MD Novel Immunotherapies for Melanoma Prolong Survival Jeffrey Weber, MD, PhD 9:30 10:00 am Break and Exhibits 10:00 11:30 am SESSION 6: Advances in Drug Development Chairperson: Saïd Sebti, MD, PhD Targeting the Akt Pathway: From Basic Science to Hypothesis-driven Clinical Trials Saïd Sebti, MD, PhD Disruptors of the Binding of Raf1 Kinase to the Tumor Suppressor Rb as Novel Anticancer Drugs Kumar Chellappan, MD Targeting Shp2 Protein Phosphatase for Drug Discovery Jerry Wu, MD 11:30 am 1:00 pm Lunch with Guest Speaker 1:00 2:30 pm SESSION 7: Sarcoma Chairperson: Douglas Letson, MD GIST Updates and Future Direction Rick Gonzalez, MD Bone Sarcomas: What Have we Learned and Where are the Opportunities for Improvement? Damon Reed, MD Soft Tissue Sarcoma: Breaking Tradition Anthony Conley, MD 2:30 pm Closing Remarks/Conference Adjourns

4 REGISTRATION FORM FLORIDA ONCOLOGY SYMPOSIUM The Ritz-Carlton Hotel Naples, Florida REGISTRATION FEE INCLUDES: Conference materials and all meal functions during conference. Name Degree/Credentials Date of Birth (MM/DD) Specialty License # Organization PAYMENT METHOD Address Check (payable to Moffitt Cancer Center) City State ZIP MasterCard Visa American Express Discover Phone Fax Amount $ Credit Card # Attendance Thursday keynote dinner Yes Attendance Saturday night dinner Yes Complimentary nurse registration accompanying physician Name License # Attendance Thursday keynote dinner Yes Attendance Saturday night dinner Yes FEES Please place a check mark next to your registration type. Physician...$ Expiration Date Cardholder Name Signature REGISTRATION OPTIONS On-line at Paper Registration, please mail along with payment to: Moffitt Cancer Center MBC-CONFPLAN Magnolia Drive Tampa, FL For further information, contact Melissa Pearson at or Melissa.Pearson@moffitt.org Physician Assistant...$ Nurse...$ Other Health Care Professional...$ Dinner Guests Thursday night dinner...$40.00 # of guests Saturday night reception and dinner...$75.00 # of guests Children (7-14) Saturday dinner...$25.00 # of children TOTAL AMOUNT On-line registration deadline May 2, On-site registration will be available. $ REFUND POLICY: An administrative fee of $50.00 will be assessed for cancellations received on or before April 22, 2011 and no refunds will be issued after this date. Events, activities, programs and facilities of the University of South Florida are available to all without regard to race, color, marital status, gender, sexual orientation, religion, national origin, disability, age, Vietnam or disabled veteran status as provided by law and in accordance with the university s respect for personal dignity. USF HPCC is an Equal Opportunity/Equal Access Institution. For disability accommodations contact USF HPCC at , a minimum of five (5) working days in advance. Program # CH /1160

5 FACULTY COURSE DIRECTOR Alan List, MD Executive Vice President & Physician-in-Chief The Frank & Carol Morsani Endowed Chair Moffitt Cancer Center Tampa, Florida Guest Faculty David Carbone, MD, PhD Professor of Medicine and Cancer Biology Vanderbilt University Cancer Center Nashville, Tennessee Kevin Collins, MD Director, Clinical Services Student Health Florida Gulf Coast University Fort Myers, Florida Levi Garraway, MD, PhD Assistant Professor Department of Medical Oncology Harvard Medical School Dana-Farber Cancer Institute Boston, Massachusetts Stefan Glück, MD, PhD, FRCPC Sylvester Professor, Department of Medicine University of Miami Leonard M. Miller School of Medicine Assistant Director, Associate Chief Division of Hematology/Oncology Sylvester Comprehensive Cancer Center Miami, Florida Steven Grant, MD Associate Director, Translational Research Co-Director, Cancer Cell Biology Program Virginia Commonwealth University Massey Cancer Center Richmond, Virginia Scott Kopetz, MD, PhD Assistant Professor GI Medical Oncology University of Texas M.D. Anderson Cancer Center Houston, Texas David Nelson, PhD President and CEO Epic Sciences San Diego, California Lisa Slama, PhD Associate Vice President Sg2 Skokie, Illinois USF Health Faculty at Moffitt Cancer Center Scott Antonia, MD, PhD Professor of Oncologic Sciences Chairman, Thoracic Oncology Department Co-Leader, Immunology Program Srikumar Chellappan, PhD Professor of Molecular Medicine & Oncologic Sciences Professor & Chair, Department of Tumor Biology Scientific Director, National Functional Genomics Center Anthony Conley, MD Sarcoma Program Hugo Fernandez, MD Associate Chair & Clinical Director Department of Blood & Marrow Transplantation Mayer Fishman, MD, PhD Associate Genitourinary Oncology Experimental Therapeutics Program Ricardo Gonzalez, MD Surgical Oncologist, Sarcoma Program & Cutaneous Oncology Ragini Kudchadkar, MD Cutaneous Oncology Program Johnathan Lancaster, MD, PhD Associate Professor, Department of Oncologic Sciences Chair, Department of Women s Oncology Director, Center for Women's Oncology Jeffrey Lancet, MD Associate Section Head, Leukemia Department of Malignant Hematology Douglas Letson, MD Professor of Radiology, Orthopaedic Oncology & Surgery Division Chair, Sarcoma Program Mary Pinder-Schneck, MD Medical Oncology Thoracic Oncology Program Javier Pinilla-Ibarz, MD, PhD Department of Malignant Hematology Julio Pow-Sang, MD Professor of Surgery & Oncologic Sciences Chief, Surgery Services Director, Robotics Program Department of GU Oncology Damon Reed, MD Medical Oncologist, Sarcoma Program Dana Rollison, PhD VP/Chief, of Health Informatics Associate Professor of Oncologic Sciences Scientific Director, Moffitt Cancer Registry Co-Scientific Director, Moffitt Tissue Core Mark Schippits, MD Director, Clinical Informatics Program Saïd Sebti, PhD Professor of Molecular Medicine & Oncologic Sciences Garcia Endowed Professor & Chair Director, Drug Discovery Comprehensive Research Center Department of Drug Discovery Wade Sexton, MD Associate Professor of Oncologic Sciences Genitourinary Program Fellowship Director Hatem Soliman, MD Comprehensive Breast Program Department of Women s Oncology Eduardo Sotomayor, MD Susan and John Sykes Endowed Chair in Malignant Hematology Department of Malignant Hematology Phillip Spiess, MD Genitourinary Oncology & Urology Gregory Springett, MD, PhD Department of Gastrointestinal Oncology Section of Pancreatic Oncology Experimental Therapeutics & Drug Discovery Department Daniel Sullivan, MD Professor of Medicine, Molecular Medicine& Oncologic Sciences Executive Vice President & Associate Center Director for Clinical Investigations Leader, Phase I Program Blood & Marrow Transplantation Department Michael Tomblyn, MD, MS, Department of Radiation Oncology Jeffrey Weber, MD, PhD Director, Donald A. Adam Comprehensive Melanoma Research Center Robert Wenham, MD, MS, FACOG Clinical Director, Gynecologic Oncology Medical Director, Moffitt Clinical Research Network Principal Investigator, Total Cancer Care Department of Women's Oncology Richard Wilder, MD, MBA, MS Associate Professor of Radiology & Oncologic Sciences Radiation Oncology/Genitourinary Oncology Department of Radiation Oncology Jie Wu, PhD Professor of Molecular Medicine & Oncologic Sciences Department of Molecular Oncology Timothy Yeatman, MD, FACS Professor of Surgery & Oncologic Sciences Executive Vice President and Founding Chief Scientific Officer Moffitt Medical Group Jonathan Zager, MD, FACS Assistant Professor of Surgery & Oncologic Sciences Cutaneous Oncology Program Sarcoma Program Jingsong Zhang, MD, PhD Genitourinary Program Experimental Therapeutics Program FACULTY DISCLOSURE USF Health adheres to the ACCME Standards regarding commercial support of continuing medical education. It is the policy of USF Health and Moffitt Cancer Center that the faculty and planning committee disclose real or apparent conflicts of interest relating to the topics of this educational activity, that relevant conflict(s) of interest are resolved, and also that speakers will disclose any unlabeled/unapproved use of drug(s) or device(s) during their presentation. Detailed disclosure will be made in the course syllabus. ACCOMMODATIONS THE RITZ-CARLTON NAPLES 280 Vanderbilt Beach Road Naples, Florida The Ritz-Carlton, Naples offers dazzling views of the Gulf of Mexico, three miles of pristine beaches, world-class restaurants and impeccable service, The Ritz-Carlton in Naples, Florida, offers an unforgettable retreat in one of the world s most beautiful locations. A block of rooms have been reserved for our conference for the special price of $ single/double occupancy. Reserve your room by calling and reference the Moffitt Cancer Center conference or on the Reservations page of by entering group code QNEQNEA. Reservations must be made on or before April 5, Check-in 4:00 pm; check-out 12 noon. Valet parking only for cost of $15 per night. H. LEE MOFFITT CANCER CENTER & RESEARCH INSTITUTE, AN NCI COMPREHENSIVE CANCER CENTER - TAMPA, FL MOFFITT 2011 H. LEE MOFFITT CANCER CENTER AND RESEARCH INSTITUTE, INC. All rights reserved. 2/11

6 H. Lee Moffitt Cancer Center & Research Institute Magnolia Drive Tampa, FL nd ANNUAL Florida Oncology Symposium: Clinical Pathways to Personalized Medicine The Ritz-Carlton Hotel Naples, Florida NON-PROFIT ORG US POSTAGE PAID TAMPA FL PERMIT NO 2849