COMPANY PRESENTATION. Hervé Brailly, CEO Jefferies 2014 Healthcare Conference. Page 1
|
|
- Drusilla Greer
- 6 years ago
- Views:
Transcription
1 COMPANY PRESENTATION Hervé Brailly, CEO Jefferies 2014 Healthcare Conference Page 1
2 Forward Looking Statement This document has been prepared by Innate Pharma S.A. (the Company ) solely for the purposes of a presentation to investors concerning the Company. This document is not to be reproduced by any person, nor to be distributed. This document contains forward-looking statements. Although the Company believes its expectations are based on reasonable assumptions, these forward-looking statements are subject to various risks and uncertainties, which could cause the Company s actual results or financial condition to differ materially from those anticipated. Please refer to the risk factors outlined from time to time in the Company s regulatory filings or publications. This document contains data pertaining to the Company's potential markets and the industry and environment in which it operates. Some of these data comes from external sources that are recognized in the field or from Company s estimates based on such sources. The information contained herein has not been independently verified. No representation, warranty or undertaking, express or implied, is made as to, and no reliance should be placed on, the fairness, accuracy, completeness or correctness of the information or opinions contained herein. The Company is under no obligation to keep current the information contained in this presentation and any opinion expressed is subject to change without notice. The Company shall not bear any liability whatsoever for any loss arising from any use of this document or its contents or otherwise arising in connection therewith. Please refer to the Document de Référence filed with the Autorité des marchés financiers ( AMF ) on April 7, 2014, available on the AMF s website ( and on the Company s website ( Such documents may not be necessarily up to date. This document and the information contained herein do not constitute an offer to sell or a solicitation of an offer to buy or subscribe to shares of the Company in any country. Page 2
3 Innate Pharma at a glance Leading scientific edge in innate immunity pharmacology First-in-class immunomodulating antibodies targeting innate immunity Portfolio of first-in-class immunomodulating mabs Primary focus in immunooncology Potential for developments in chronic Inflammation Page 3
4 NK cell activation improves survival in AML patients Following allo-transplantation, NK cells protect against tumor relapse in AML patients NK activation NK inhibition Effects are: Durable Safe Controlled by KIR Mediated by NK cells Ruggeri et al, Blood, 2007 Page 4
5 Innate Pharma s pipeline PROGRAM TARGET INDICATION Valid PC PI PII PIII Lirilumab (IPH2102/BMS ) licensed to Bristol-Myers Squibb KIR2DL1,2,3 Acute Myeloid Leukemia Solid tumors, comb. with ipilimumab Solid tumors, comb. with nivolumab IPH2201 NKG2A Cancer IPH4102 KIR3DL2 Cutaneous T-cell lymphomas IPH33 TLR3 Inflammation / Autoimmunity IPH43 MICA Cancer Page 5
6 Innate Pharma positioning in immuno-oncology Clinical pipeline of immunomodulating antibodies in cancer TARGET PHASE I PHASE II PHASE III MARKET Inhibitory receptors CTLA-4 AZN BMS PD-1 / PD-L1 Merck KGaA, AZN, AMP/GSK, BMS BMS, Merck, Roche, AZN KIR IPH/BMS LAG-3 BMS IMP NKG2A IPH Activating receptors CD137 Pfizer BMS CSF-1R B7-H3 CD40 OX40 GITR CD27 AMG, LLY, Roche Servier/MGNX CRUK, Roche AZN GITR Inc, Merck Celldex Page 6
7 Lirilumab Page 7
8 First-in-class NK cell checkpoint inhibitor Fully human antibody blocking NK cell inhibitory receptor KIR2DL1/2/3 (IgG4) MHC class I KIR receptor - o Blocks interaction with MHC class 1 molecules Stressed cell Activating ligand NK Cell + Activating receptor KIR signaling inhibits NK cell Development and commercialization rights licenced to Bristol-Myers Squibb in 2011 o $35 million upfront, up to $430 million in milestone payments, double-digit royalties Stressed cell NK Cell + KIR-blockade allows NK activation Page 8
9 Intergroup ALFA/Goelams EFFIKIR Phase II trial Double-blind placebo-controled randomized trial of lirilumab in AML First randomized Phase II of lirilumab Sponsored by Innate 1:1:1 Elderly CR1 Max 2 consolidations Not eligible for HST Minimization Center 1º vs 2 nd AML No. consolidations Cytogenetics R A N D O M I Z E Lirilumab 0.1 mg/kg q 12 weeks Intermittent full KIR occupancy Lirilumab 1.0 mg/kg q 4 weeks Continuous full KIR occupancy Placebo q 4 weeks Treatment for 2 years Primary endpoint: Leukemia-Free Survival (Independent Review Committee) N=50 per arm (100 events) for overall α at 0.05 one-sided and power of 0.80, assuming median LFS of 12 months in the control group vs. 20 months in the treatment groups Recruitment period: months; Maximum follow-up period: 24 months after last patient entry Page 9
10 Phase I study of lirilumab in combination with nivolumab Patients with advanced solid tumors Dose escalation completed Cohort expansion in various solid tumors: > Nivolumab 3mg/kg, every other weeks and lirilumab 3mg/kg, every four weeks > Patients dosed for up to two years Participating centers (USA): > Memorial Sloan-Kettering Cancer Center, New York, NY > Dana-Farber Cancer Institute, Boston, MA > University of Chicago Comprehensive Cancer Center, Chicago, IL > Johns Hopkins Comprehensive Cancer Center, Baltimore, MD > Providence Portland Medical Center, Portland, OR Estimated enrollment: Page 10
11 Phase I study of lirilumab in combination with ipilimumab Patients with advanced solid tumors Regimen schedule: concurrent administration q3 weeks x 4 then q12 weeks x 4 Dose escalation: observation period of 9 weeks after first cycle Dosage during dose escalation Dose level number Total number of patients Cohort expansion: > Treat at the MTD or maximum administered dose Indications: > Non-small cell lung cancer > Castrate resistant prostate cancer > Melanoma Lirilumab, mg/kg Ipilimumab, mg/kg Total Participating centers (USA) > Memorial Sloan-Kettering Cancer Center, New York, NY > Dana-Farber Cancer Institute, Boston, MA > Ohio State University, Columbus, OH > Sarah Cannon Research Institute/ Tennessee Oncology, Nashville, TN > Moffitt Cancer Center, Tampa, FL > Masonic Cancer Center, University of Minnesota, MN Page 11
12 Lirilumab enhances efficacy of rituximab KIR blockade enhances ADCC function of NK cells in vivo and in vitro Kohrt et al., Blood, 2013 Page 12
13 IPH2201, anti-nkg2a Page 13
14 NKG2A: a checkpoint receptor on infiltrating NK and T cells NK cell CD8+ T cell Effector functions Effector functions NKG2D NKp CD94/NKG2A TCR + - CD94/NKG2A CD8 MIC-A??? HLA-E HLA-A, B (C, E) HLA-E Target cell (tumor or infected cell, stressed cell in chronic inflammation) Page 14
15 Potential for development of IPH2201 in diverse types of hematological and solid tumors HLA-E upregulated on a wide variety of tumor types; can correlate with poor prognosis Internal data Page 15
16 Phase II ready Dose-escalation safety trial conducted by Novo Nordisk A/S o 92 pts, moderate RA, low-dose MTX o IV single dose (SD, up to 10 mg/kg) and SC SD and MD (up to 4 mg/kg) o No safety issues identified, MTD not reached, no DLT Favorable safety profile, and first-in-class target, suggest wide potential for combination therapy Page 16
17 IPH2201 initial development plan H&N Phase 2 single agent H&N Phase 2 combo cetuximab CLL Phase 2 combo ibrutinib Ovarian Phase 2 single agent Ovarian Phase 2 combo SOC Page 17
18 Portfolio of first-in-class therapeutic mabs with diverse MOAs Compound Ab type MOA Anti-KIR2DL1/2/3 IgG4 Activate NK cells Anti-NKG2A IgG4 Activate NK and CD8+ T cells Anti-KIR3DL2 IgG1 ADCC, target tumor antigen Rare disease Anti-TLR3 IgG4 Blocking inflammation Anti-MICA Other targets ADC technology TBD ADCC, target tumor antigen Modulating NK cells Beyond I-O Beyond Cancer Beyond NK cells Page 18
19 Corporate information Cash on hand: 37.2 million at March 31, 2014 Listed on Euronext, IPO in November 2006 Euronext Paris: FR IPH 128m raised since inception Stock liquidity (in 2013) 46.7m outstanding shares (48.1m diluted) Average daily trading volume > Analyst coverage: Goldman Sachs, Leerink, Gilbert Dupont 55.3% Shareholders Novo Nordisk A/S * BPI Groupe * 11.1% 5.9% 2.6% 10.4% 8.8% 5.9% Wellington Management Company OrbiMed Fidelity Management Management Other/Autre * Shareholders represented at the Supervisory Board Page 19
20 Investor relations Laure-Hélène Mercier Director, Investor relations Tel: +33 (0) Fax: +33 (0) Page 20
NOVEL CHECKPOINTS IN IMMUNO-ONCOLOGY KIR NKG2A. C5aR. NKp46 HALF-YEAR RESULTS. Tumor antigen KIR3DL2 CD39 MICA/B CD73 SEPTEMBER 18, 2017
NOVEL CHECKPOINTS IN IMMUNO-ONCOLOGY KIR NKG2A NKp46 C5aR Tumor antigen HALF-YEAR RESULTS KIR3DL2 MICA/B CD73 CD39 SEPTEMBER 18, 2017 Page 2 FORWARD LOOKING STATEMENT This document has been prepared by
More informationAACR WRAP UP CALL NICOLAI WAGTMANN APRIL 19 TH, 2016
AACR WRAP UP CALL NICOLAI WAGTMANN APRIL 19 TH, 216 FORWARD LOOKING STATEMENT This document has been prepared by Innate Pharma S.A. (the Company ) solely for the purposes of a presentation to investors
More informationANTI-C5AR ACQUISITION
KIR2DL1,2,3 NKG2A NKP46 KIR3DL2 MICA/B CD73 CD39 ANTIC5AR ACQUISITION JUNE 2017 NOVEL CHECKPOINTS IN IMMUNOONCOLOGY Page 2 FORWARD LOOKING STATEMENT This document has been prepared by Innate Pharma S.A.
More informationTHE INNATE IMMUNITY COMPANY
THE INNATE IMMUNITY COMPANY NEXT GENERATION IMMUNOTHERAPIES: NK CELLS AND OTHER TARGETS STEPHANIE CORNEN 5TH IMMUNOTHERAPY OF CANCER CONFERENCE (ITOC5) MARCH 2018 Page 2 FORWARD LOOKING STATEMENT This
More informationUnderstanding Checkpoint Inhibitors: Approved Agents, Drugs in Development and Combination Strategies. Michael A. Curran, Ph.D.
Understanding Checkpoint Inhibitors: Approved Agents, Drugs in Development and Combination Strategies Michael A. Curran, Ph.D. MD Anderson Cancer Center Department of Immunology Disclosures I have research
More informationBreakthrough Cancer Therapies: Directing the Immune System to Eliminate Tumor Cells. Corporate Presentation June 2015
Breakthrough Cancer Therapies: Directing the Immune System to Eliminate Tumor Cells Corporate Presentation June 2015 Forward-looking statements / safe harbor This presentation and the accompanying oral
More informationImmuno-Oncology Clinical Trials Update: Therapeutic Anti-Cancer Vaccines Issue 7 April 2017
Delivering a Competitive Intelligence Advantage Immuno-Oncology Clinical Trials Update: Therapeutic Anti-Cancer Vaccines Issue 7 April 2017 Immuno-Oncology CLINICAL TRIALS UPDATE The goal of this MONTHLY
More informationCORPORATE PRESENTATION
CORPORATE PRESENTATION June 2017 FORWARD LOOKING SAFE HARBOR STATEMENT This presentation contains forward-looking statements within the meaning of the Private Securities Litigation Reform Act of 1995.
More informationDetermined to realize a future in which people with cancer live longer and better than ever before Q Conference Call
Reimagining Cancer Treatment Determined to realize a future in which people with cancer live longer and better than ever before Q1 2016 Conference Call 1 Forward-Looking Statements Disclosure This presentation
More informationCorporate Presentation
Corporate Presentation Leerink Global Healthcare Conference February 14 th -15 th, 2018 C O N F I D E N T I A L a n d P R O P R I E T A R Y Forward Looking Statements / Safe Harbor This presentation contains
More informationCorporate Presentation November Transforming Immuno-Oncology Using Next-Generation Immune Cell Engagers
Corporate Presentation November 2015 Transforming Immuno-Oncology Using Next-Generation Immune Cell Engagers Forward-looking statements / safe harbor This presentation and the accompanying oral commentary
More informationCowen Health Care Conference
Cowen Health Care Conference Dr. Fouad Namouni Head of Medical March 7, 2016 1 Forward-Looking Information This presentation contains statements about the Company s future plans and prospects that constitute
More informationONO PHARMACEUTICAL CO., LTD. and Bristol-Myers Squibb Announce Strategic Immuno-Oncology Collaboration in Japan, South Korea and Taiwan
ONO PHARMACEUTICAL CO., LTD. and Bristol-Myers Squibb Announce Strategic Immuno-Oncology Collaboration in Japan, South Korea and Taiwan Companies to develop and commercialize Opdivo (nivolumab), ipilimumab,
More informationDetermined to realize a future in which people with cancer live longer and better than ever before
Determined to realize a future in which people with cancer live longer and better than ever before 4Q 2016 EARNINGS PRESENTATION MARCH 2017 1 Forward-looking statements disclosure This presentation contains
More informationCorporate Presentation May Transforming Immuno-Oncology Using Next-Generation Immune Cell Engagers
Corporate Presentation May 2016 Transforming Immuno-Oncology Using Next-Generation Immune Cell Engagers Forward-looking statements / safe harbor This presentation and the accompanying oral commentary contain
More informationIMMUNOMEDICS, INC. Advanced Antibody-Based Therapeutics. Jefferies 2014 Global Healthcare Conference Cynthia L. Sullivan, President and CEO
IMMUNOMEDICS, INC. Advanced Antibody-Based Therapeutics Oncology Autoimmune Diseases Jefferies 2014 Global Healthcare Conference Cynthia L. Sullivan, President and CEO Forward-Looking Statements This presentation,
More informationQ4 Report Webcast February 7, 2019 Presenters: Renée Aguiar-Lucander, CEO Fredrik Johansson, CFO
Q4 Report 2018 Webcast February 7, 2019 Presenters: Renée Aguiar-Lucander, CEO Fredrik Johansson, CFO Disclaimer Important information This presentation has been prepared by Calliditas Therapeutics AB
More informationImmuno-Oncology Clinical Trials Update: Checkpoint Inhibitors Others (not Anti-PD-L1/PD-1) Issue 4 January 2017
Delivering a Competitive Intelligence Advantage Immuno-Oncology Clinical Trials Update: Checkpoint Inhibitors Others (not Anti-PD-L1/PD-1) Issue 4 January 2017 Immuno-Oncology CLINICAL TRIALS UPDATE The
More informationASCO 2018 Investor Meeting
ASCO 2018 Investor Meeting June 4, 2018 1 Forward-Looking Information This presentation contains statements about the Company s future plans and prospects that constitute forward-looking statements for
More informationDetermined to realize a future in which people with cancer live longer and better than ever before
Determined to realize a future in which people with cancer live longer and better than ever before 3Q 2018 EARNINGS PRESENTATION NOVEMBER 2018 1 Forward-looking statements disclosure This presentation
More informationCOMPANY PRESENTATION. January 2019
COMPANY PRESENTATION January 2019 1 FORWARD-LOOKING STATEMENT This presentation does not constitute or form part of any offer or invitation to purchase or subscribe for, or any offer to underwrite or otherwise
More informationCorporate Presentation March 2016
Corporate Presentation March 2016 Forward Looking Safe Harbor Statement This presentation contains forward-looking statements within the meaning of the Private Securities Litigation Reform Act of 1995.
More informationImmune checkpoint inhibitors in Hodgkin and non-hodgkin Lymphoma: How do they work? Where will we use them? Stephen M. Ansell, MD, PhD Mayo Clinic
Immune checkpoint inhibitors in Hodgkin and non-hodgkin Lymphoma: How do they work? Where will we use them? Stephen M. Ansell, MD, PhD Mayo Clinic Conflicts of Interest Research Funding from Bristol Myers
More informationCorporate Presentation: Jefferies Global Healthcare Conference June 7, 2018
Corporate Presentation: Jefferies Global Healthcare Conference June 7, 2018 2018 CytomX Therapeutics, Inc. 1 Forward Looking Statements Special Note Regarding Forward-Looking Statements This presentation
More informationASCO 2014 Highlights*
ASCO 214 Highlights* Investor Meeting June 2, 214 *American Society of Clinical Oncology, May 3 June 3, 214 Forward-Looking Information During this meeting, we will make statements about the Company s
More informationDawson James Conference
Dawson James Conference October 2018 Forward-looking Statements Except for historical information, this presentation contains forward-looking statements, which reflect IMV s current expectations regarding
More informationJune IMMUNE DESIGN The in vivo generation of cytotoxic CD8 T cells (CTLs)
June 2015 IMMUNE DESIGN The in vivo generation of cytotoxic CD8 T cells (CTLs) 1 Forward-looking Statements This presentation contains forward-looking statements with respect to, among other things, our
More informationBank of America Merrill Lynch 2018 Health Care Conference. Reinventing Therapeutic Antibodies for the Treatment of Cancer
Bank of America Merrill Lynch 2018 Health Care Conference Reinventing Therapeutic Antibodies for the Treatment of Cancer May 17, 2018 1 Forward Looking Statements Special Note Regarding Forward-Looking
More informationNovel RCC Targets from Immuno-Oncology and Antibody-Drug Conjugates
Novel RCC Targets from Immuno-Oncology and Antibody-Drug Conjugates Christopher Turner, MD Vice President, Clinical Science 04 November 2016 Uveal Melanoma Celldex Pipeline CANDIDATE INDICATION Preclinical
More informationJP Morgan Healthcare Conference
JP Morgan Healthcare Conference Lamberto Andreotti Chief Executive Officer January 14, 2014 Forward-Looking Information During this meeting, we will make statements about the Company s future plans and
More informationMore cancer patients are being treated with immunotherapy, but
Bristol-Myers Squibb and Five Prime Present Phase 1a/1b Data Evaluating Cabiralizumab (anti-csf-1 receptor antibody) with Opdivo (nivolumab) in Patients with Advanced Solid Tumors PRINCETON, N.J. & SOUTH
More informationClinical Activity and Safety of Anti-PD-1 (BMS , MDX-1106) in Patients with Advanced Non-Small-Cell Lung Cancer
Clinical Activity and Safety of Anti-PD-1 (BMS-936558, MDX-1106) in Patients with Advanced Non-Small-Cell Lung Cancer J.R. Brahmer, 1 L. Horn, 2 S.J. Antonia, 3 D. Spigel, 4 L. Gandhi, 5 L.V. Sequist,
More informationALLIGATOR BIOSCIENCE AB (PUBL) 30 January 2018 Per Norlén, CEO
ALLIGATOR BIOSCIENCE AB (PUBL) 30 January 2018 Per Norlén, CEO 1 Disclaimer FORWARD LOOKING STATEMENTS This presentation contains forward-looking statements that provide Alligator s expectations or forecasts
More informationNational Bank 8th Annual Quebec Conference TSX: IMV. May 30, IMV Inc. All rights reserved.
National Bank 8th Annual Quebec Conference TSX: IMV May 30, 2018 Forward-looking Statements Except for historical information, this presentation contains forward-looking statements, which reflect IMV Inc.
More informationCorporate Overview. June 2018 NASDAQ:FPRX
Corporate Overview June 2018 NASDAQ:FPRX Forward-Looking Statements Disclaimer This presentation contains forward-looking statements within the meaning of the Private Securities Litigation Reform Act of
More information2018 KSMO Immune Oncology Forum. Immune checkpoint inhibitors in hematologic. malignancies: evidences and perspectives 서울아산병원종양내과 홍정용
2018 KSMO Immune Oncology Forum Immune checkpoint inhibitors in hematologic malignancies: evidences and perspectives 서울아산병원종양내과 홍정용 2018-07-18 Contents Introduction Immune checkpoint inhibtors in lymphomas
More informationDISCOVERING AND DEVELOPING NEW IMMUNE ACTIVATING MECHANISMS AND ANTIBODIES TO IMPROVE CANCER SURVIVAL
DISCOVERING AND DEVELOPING NEW IMMUNE ACTIVATING MECHANISMS AND ANTIBODIES TO IMPROVE CANCER SURVIVAL Annual General Meeting 24 April 2018 Björn Frendéus, Acting CEO & CSO 1 IMMUNOTHERAPY HAS TRANSFORMED
More informationCiti Global Healthcare Conference
Citi Global Healthcare Conference Francis Cuss, MB BChir, FRCP Chief Scientific Officer February 24, 2014 1 Forward-Looking Information During this meeting, we will make statements about the Company s
More informationPLEO-CMT Top-line Results. Presentation October 16, 2018
PLEO-CMT Top-line Results Presentation October 16, 2018 Disclaimer References herein to this presentation (the Presentation ) shall mean and include this document, any oral presentation accompanying this
More informationLeerink Immuno-Oncology Roundtable Conference
Leerink Immuno-Oncology Roundtable Conference September 28, 2017 NASDAQ:FPRX Forward-Looking Statements Disclaimer This presentation contains forward-looking statements within the meaning of the Private
More informationBringing Breakthrough Pioneering Therapies to Patients with Life-Threatening Diseases. Corporate Presentation. March 2017
Bringing Breakthrough Pioneering Therapies to Patients with Life-Threatening Diseases Corporate Presentation March 2017 Disclaimer In addition to historical facts or statements of current condition, this
More informationGSK Oncology. Axel Hoos, MD, PhD Senior Vice President, Oncology R&D. March 8, 2017
GSK Oncology Axel Hoos, MD, PhD Senior Vice President, Oncology R&D March 8, 217 GSK pipeline Oncology R&D Strategy Maximizing survival through transformational medicines and combinations Cancer Epigenetics
More informationRecurrent Ovarian Cancer Phase 1b Results
Recurrent Ovarian Cancer Phase 1b Results December 5 th, 2017 Forward-looking Statements Except for historical information, this presentation contains forward-looking statements, which reflect Immunovaccine
More informationCorporate Overview June 2014 Jefferies Healthcare Conference NASDAQ: GLYC
Corporate Overview June 2014 Jefferies Healthcare Conference NASDAQ: GLYC Forward-Looking Statements To the extent that statements contained in this presentation are not descriptions of historical facts
More informationNewLink Genetics Corporation Provides Operational Update and Reports Second Quarter 2015 Financial Results
July 31, 2015 NewLink Genetics Corporation Provides Operational Update and Reports Second Quarter 2015 Financial Results -Management to Host Conference Call Today at 8:30 a.m. ET- AMES, Iowa, July 31,
More informationImmuno-Oncology. Axel Hoos, MD, PhD Senior Vice President, Oncology R&D. February 24, 2016
Immuno-Oncology Axel Hoos, MD, PhD Senior Vice President, Oncology R&D February 24, 216 GSK Pipeline Oncology R&D strategy Focusing on 3 areas fundamental to oncology Cancer Epigenetics Long-Term Survival
More informationTransforming science into medicine
Transforming science into medicine 2 Forward-looking statements This presentation contains forward-looking statements. These statements include words like may, expects, believes, plans, scheduled, and
More informationCorporate Presentation: 2018 Wedbush PacGrow Healthcare Conference August 14, 2018
Corporate Presentation: 2018 Wedbush PacGrow Healthcare Conference August 14, 2018 2018 CytomX Therapeutics, Inc. 1 Forward Looking Statements Special Note Regarding Forward-Looking Statements This presentation
More informationDetermined to realize a future in which people with cancer live longer and better than ever before 4Q18 EARNINGS PRESENTATION MARCH 2019
Determined to realize a future in which people with cancer live longer and better than ever before 4Q18 EARNINGS PRESENTATION MARCH 2019 Forward-looking statements disclosure This presentation contains
More informationANNUAL REPORT 2017 PRESS & ANALYST CONFERENCE CALL MARTINSRIED, MARCH 22, 2018
ANNUAL REPORT 2017 PRESS & ANALYST CONFERENCE CALL MARTINSRIED, MARCH 22, 2018 Prof. Dolores J. Schendel, CEO/CSO Dr. Thomas Taapken, CFO Dr. Kai Pinkernell, SVP Clinical Affairs/CMO "Safe Harbor" Statement
More informationNektar Investor & Analyst Call. Nektar & z Bristol-Myers Squibb Collaboration. February 14, 2018
Nektar Investor & Analyst Call Nektar & z Bristol-Myers Squibb Collaboration February 14, 2018 This presentation includes forward-looking statements regarding Nektar s proprietary drug candidates, the
More informationCelldex Provides Corporate Update and Reports First Quarter 2018 Results
May 10, 2018 Celldex Provides Corporate Update and Reports First Quarter 2018 Results HAMPTON, N.J., May 10, 2018 (GLOBE NEWSWIRE) -- Celldex Therapeutics, Inc. (NASDAQ:CLDX) today reported business and
More informationESMO 2016 * Investor Meeting October 9, *European Society of Medical Oncology, October 7-11, 2016 ESMO 2016 NOT FOR PRODUCT PROMOTIONAL USE
ESMO 2016 * Investor Meeting October 9, 2016 *European Society of Medical Oncology, October 7-11, 2016 1 Forward-Looking Information During this meeting, we will make statements about the Company s future
More informationBuilding a Fully Integrated Biopharmaceutical Company. June 2014
Building a Fully Integrated Biopharmaceutical Company June 2014 Forward-Looking Statements This presentation contains forward-looking statements within the meaning of The Private Securities Litigation
More informationGSK Oncology R&D Update
GSK Oncology R&D Update Axel Hoos, MD Senior Vice President, Oncology R&D February 2019 Cautionary statement regarding forward-looking statements This presentation may contain forward-looking statements.
More information3Q 2016 presentation
Arming the patient s immune system to fight cancer 3Q 2016 presentation 17 November 2016 Important notice and disclaimer This report contains certain forward-looking statements based on uncertainty, since
More informationNOXOPHARM CORPORATE PRESENTATION FNN SHAW&PARTNERS INVESTOR EVENT ASX: NOX
Date: 14 August, 2018 Sydney, Australia ASX: NOX Noxopharm Limited NOXOPHARM CORPORATE PRESENTATION FNN SHAW&PARTNERS INVESTOR EVENT ABN 50 608 966 123 Registered Office and Operations Office: Suite 3,
More informationCompany presentation. Biotech Showcase, San Fransisco, 10 January Per Norlén, CEO
Company presentation Biotech Showcase, San Fransisco, 10 January 2017 Per Norlén, CEO Disclaimer This presentation regarding Alligator Bioscience AB ( Alligator ) and its contents are confidential and
More informationIncyte Reports 2014 Second Quarter Financial Results and Updates Shareholders on Key Clinical Programs
Print Page Close Window Press Release Incyte Reports 2014 Second Quarter Financial Results and Updates Shareholders on Key Clinical Programs $84.0 million of 2014 second quarter net product revenues from
More information(generic name: ipilimumab) Injection 50 mg ( Yervoy ), a human anti-human CTLA-4 monoclonal. August 21, 2018
August 21, 2018 Opdivo Approved for Supplemental Applications for Expanded Indications of Malignant Pleural Mesothelioma and Adjuvant Treatment of Melanoma, Change in Dosage and Administration (D&A) of
More informationDynavax Corporate Presentation
Dynavax Corporate Presentation Forward-Looking Statements This presentation contains forward-looking statements, including statements regarding our HEPLISAV-B TM regulatory submissions, product profile,
More informationClinical: Ipilimumab (MDX-010) Update and Next Steps
Clinical: Ipilimumab (MDX-010) Update and Next Steps Geoffrey M. Nichol, M.D., M.B.A. Senior Vice President, Product Development Medarex, Inc. R&D Day December 9, 2005 Ipilimumab: New Class of Cancer Therapy
More informationForward-Looking Statements
Forward-Looking Statements This presentation contains forward-looking statements, including statements related to Seattle Genetics corporate priorities, financial guidance and anticipated upcoming activities,
More informationImmune Checkpoints. PD Dr med. Alessandra Curioni-Fontecedro Department of Hematology and Oncology Cancer Center Zurich University Hospital Zurich
Immune Checkpoints PD Dr med. Alessandra Curioni-Fontecedro Department of Hematology and Oncology Cancer Center Zurich University Hospital Zurich Activation of T cells requires co-stimulation Science 3
More informationCOMPANY OVERVIEW. June CytomX Therapeutics, Inc.
COMPANY OVERVIEW June 2016 2016 CytomX Therapeutics, Inc. Forward Looking Statements Special Note Regarding Forward-Looking Statements This presentation may contain projections and other forward-looking
More informationJefferies 2016 Healthcare Conference. Reid Huber, PhD Chief Scientific Officer
Jefferies 2016 Healthcare Conference Reid Huber, PhD Chief Scientific Officer June 8, 2016 Forward-looking Statements Except for the historical information set forth herein, the matters set forth in this
More informationLION. Corporate Presentation June 2016 BIOTECHNOLOGIES. Leadership & Innovation in Oncology
LION BIOTECHNOLOGIES Leadership & Innovation in Oncology Corporate Presentation June 2016 Forward-Looking Statements This presentation contains forward-looking statements within the meaning of the Private
More informationBringing Breakthrough Pioneering Therapies to Patients with Life-Threatening Diseases. Corporate Presentation. September 2017
Bringing Breakthrough Pioneering Therapies to Patients with Life-Threatening Diseases Corporate Presentation September 2017 Disclaimer In addition to historical facts or statements of current condition,
More informationBL-8040: A Novel CXCR4 Antagonist
BL-8040: A Novel CXCR4 Antagonist December 2012 Forward Looking Statements This presentation contains "forward-looking statements." These statements include words like "may," "expects," "believes," plans,
More informationJP Morgan Healthcare Conference
JP Morgan Healthcare Conference Giovanni Caforio Chief Executive Officer January 12, 2016 1 Forward-Looking Information This presentation contains statements about the Company s future plans and prospects
More informationSunesis Pharmaceuticals Reports Second Quarter 2011 Financial Results
Investor and Media Inquiries: David Pitts Argot Partners 212-600-1902 Eric Bjerkholt Sunesis Pharmaceuticals Inc. 650-266-3717 Sunesis Pharmaceuticals Reports Second Quarter 2011 Financial Results SOUTH
More informationJefferies 2017 Global Healthcare Conference. Stephen Doberstein, Ph.D. Senior Vice President & Chief Scientific Officer
Jefferies 2017 Global Healthcare Conference Stephen Doberstein, Ph.D. Senior Vice President & Chief Scientific Officer June 7, 2017 This presentation includes forward-looking statements regarding Nektar
More informationOncology Pipeline Analytics
Oncology Pipeline Analytics Trials, Drug Classes, Indications, Correlations and Strategies Report Brochure O n c o l o g y P i p e l i n e A n a l y t i c s Greystone Research Associates is pleased to
More informationLiving Immunotherapies. Corporate Presentation OCTOBER 2018
Living Immunotherapies Corporate Presentation OCTOBER 2018 All of the information herein has been prepared by the Company solely for use in this presentation. The information contained in this presentation
More informationFIRSTQUARTER2018 RESULTSPRESENTATION
FIRSTQUARTER2018 RESULTSPRESENTATION May 14 th 2018 Juan Lladó CEO 1 DISCLAIMER This document has been prepared by Técnicas Reunidas S.A. (the Company) solely for use at presentations held in connection
More informationChallenges in Distinguishing Clinical Signals to Support Development Decisions: Case Studies
Challenges in Distinguishing Clinical Signals to Support Development Decisions: Case Studies David Feltquate MD, PhD Head of Early Clinical Development, Oncology Bristol-Myers Squibb, Princeton, NJ Challenges
More informationJanssen Hematologic Malignancy Portfolio
Janssen Hematologic Malignancy Portfolio Recorded Webcast: Update for Analysts and Investors January 216 Oncology 1 Safe Harbor Statement This webcast contains "forward-looking statements" as defined in
More informationThe Next Generation of Immunotherapy Platforms. 36 th Annual J.P. Morgan Healthcare Conference January 2018
The Next Generation of Immunotherapy Platforms 36 th Annual J.P. Morgan Healthcare Conference January 2018 Forward-Looking Statements This presentation contains certain forward-looking information about
More informationHeat Biologics. Corporate Presentation March 9, 2018
Heat Biologics Corporate Presentation March 9, 2018 Forward Looking Statements This presentation includes statements that are, or may be deemed, forward-looking statements within the meaning of the Private
More informationNASDAQ & TSX: IMV. BIO Investor Forum. October IMV Inc. All rights reserved.
NASDAQ & TSX: IMV BIO Investor Forum October 2018 Forward-looking Statements Except for historical information, this presentation contains forward-looking statements, which reflect IMV s current expectations
More informationNASDAQ: PBMD, ASX: PRR
NASDAQ: PBMD, ASX: PRR Notice: Forward Looking Statements The purpose of the presentation is to provide an update of the business of Prima BioMed Ltd ACN 009 237 889 (ASX:PRR; NASDAQ:PBMD). These slides
More informationInducing Tumor-Specific Ischemic Necrosis to Enhance the Efficacy of Checkpoint Inhibitors and Chemotherapy
Inducing Tumor-Specific Ischemic Necrosis to Enhance the Efficacy of Checkpoint Inhibitors and Chemotherapy Company Overview, September 2018 Safe Harbor Statement This presentation contains forward-looking
More informationADAPTIMMUNE INVESTOR PRESENTATION. August 2016
ADAPTIMMUNE INVESTOR PRESENTATION August 2016 DISCLAIMER This presentation contains forward-looking statements, as that term is defined under the Private Securities Litigation Reform Act of 1995 (PSLRA),
More informationFrédéric Triebel MD, PhD World Immunotherapy Congress Basel, October 30, 2018
Two ACTive immunotherapies in melanoma (TACTI-mel): results of a phase I trial combining a soluble LAG-3 receptor (Eftilagimod Alpha) with Pembrolizumab Frédéric Triebel MD, PhD World Immunotherapy Congress
More informationNew Systemic Therapies in Advanced Melanoma
New Systemic Therapies in Advanced Melanoma Sanjay Rao, MD FRCPC Medical Oncologist (BCCA-CSI) Clinical Assistant Professor, UBC Faculty of Medicine SON Fall Update October 22, 2016 Disclosures Equity
More informationNASDAQ: PBMD, ASX: PRR
NASDAQ: PBMD, ASX: PRR Notice: Forward Looking Statements The purpose of the presentation is to provide an update of the business of Prima BioMed Ltd ACN 009 237 889 (ASX:PRR; NASDAQ:PBMD). These slides
More informationFive Prime Therapeutics, Inc. Corporate Overview
Five Prime Therapeutics, Inc. Corporate Overview June 2015 NASDAQ:FPRX Forward-Looking Statements Disclaimer This presentation contains forward-looking statements within the meaning of the Private Securities
More informationCorporate Presentation June Curis, Inc All Rights Reserved
Corporate Presentation June 2018 Curis, Inc. 2018 All Rights Reserved Forward Looking Statements This presentation contains certain forward-looking statements about Curis, Inc. ( we, us, or the Company
More informationDisclosures. Speakers Bureau. Clinical Trial Research Funding
Interim Results of an Ongoing Phase 1, Dose Escalation Study of MGA271 (Enoblituzumab), an Fc optimized Humanized Anti B7 H3 Monoclonal Antibody, in Patients with Advanced Solid Cancer Powderly J a, Cote
More informationInvestor presentation. Bioshares Biotech Summit July 2017
Investor presentation Bioshares Biotech Summit 2017 22 July 2017 1 Disclaimer Some of the information in this presentation may refer to Dimerix Limited ( Dimerix or the Company ) based on information available
More informationObsEva Reports First Quarter 2018 Financial Results and Provides Business Update
ObsEva Reports First Quarter 2018 Financial Results and Provides Business Update -Key First Quarter 2018 Clinical Milestones Achieved Patient randomization completed in Phase 2b EDELWEISS trial of OBE2109
More informationActinium Pharmaceuticals, Inc.
, Inc. Actimab-A MRD Consolidation Strategy in MRD+ AML July 10, 2018 1 Disclaimer and Safe Harbor Some of the information presented herein may contain projections or other forward-looking statements regarding
More informationINTERIM RESULTS AS OF JUNE 30, 2016 CSE/OMX:BAVA, OTC:BVNRY
INTERIM RESULTS AS OF JUNE 30, 2016 Q2 CSE/OMX:BAVA, OTC:BVNRY FORWARD-LOOKING STATEMENTS This presentation includes forward-looking statements that involve risks, uncertainties and other factors, many
More informationThird Quarter 2018 Financial Results. November 1, 2018
Third Quarter 2018 Financial Results November 1, 2018 Agios Conference Call Participants Prepared Remarks Introduction RENEE LECK, Associate Director, Investor Relations Business Highlights & 2018 Key
More informationNatural Killer (NK) cells and Programmed cell death protein-1 (PD-1)
Natural Killer (NK) cells and Programmed cell death protein-1 (PD-1) Sujan Badal, MS2; Zachary B. Davis, PhD; Jeffrey Miller, MD Department of Medicine, Division of Hematology, Oncology, and Transplantation
More informationNew Data from Ongoing Melanoma Study and Clinical Development Strategy Update
New Data from Ongoing Melanoma Study and Clinical Development Strategy Update Webcast - 29 th / 30 th May 2018 (ASX: IMM, NASDAQ: IMMP) Notice: Forward Looking Statements The purpose of the presentation
More informationReleasing the Brakes on Tumor Immunity: Immune Checkpoint Blockade Strategies
Releasing the Brakes on Tumor Immunity: Immune Checkpoint Blockade Strategies Jason Muhitch, PhD MIR 509 October 1 st, 2014 Email: jason.muhitch@roswellpark.org 0 Holy Grail of Tumor Immunity Exquisite
More informationQ Financial Update November 6, 2018 NASDAQ:FPRX
Q3 2018 Financial Update November 6, 2018 NASDAQ:FPRX 2 Forward-Looking Statements Disclaimer Forward-looking statements contained in this presentation include statements regarding (i) the timing of initiation,
More informationTarGeting B-Cell Diseases
TarGeting B-Cell Diseases Forward Looking Safe Harbor Statement This presentation contains forward-looking statements within the meaning of the Private Securities Litigation Reform Act of 1995. These statements
More informationName of Policy: Yervoy (Ipilimumab)
Name of Policy: Yervoy (Ipilimumab) Policy #: 335 Latest Review Date: October 2013 Category: Pharmacology Policy Grade: A Background/Definitions: As a general rule, benefits are payable under Blue Cross
More information