COMPANY PRESENTATION. Hervé Brailly, CEO Jefferies 2014 Healthcare Conference. Page 1

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1 COMPANY PRESENTATION Hervé Brailly, CEO Jefferies 2014 Healthcare Conference Page 1

2 Forward Looking Statement This document has been prepared by Innate Pharma S.A. (the Company ) solely for the purposes of a presentation to investors concerning the Company. This document is not to be reproduced by any person, nor to be distributed. This document contains forward-looking statements. Although the Company believes its expectations are based on reasonable assumptions, these forward-looking statements are subject to various risks and uncertainties, which could cause the Company s actual results or financial condition to differ materially from those anticipated. Please refer to the risk factors outlined from time to time in the Company s regulatory filings or publications. This document contains data pertaining to the Company's potential markets and the industry and environment in which it operates. Some of these data comes from external sources that are recognized in the field or from Company s estimates based on such sources. The information contained herein has not been independently verified. No representation, warranty or undertaking, express or implied, is made as to, and no reliance should be placed on, the fairness, accuracy, completeness or correctness of the information or opinions contained herein. The Company is under no obligation to keep current the information contained in this presentation and any opinion expressed is subject to change without notice. The Company shall not bear any liability whatsoever for any loss arising from any use of this document or its contents or otherwise arising in connection therewith. Please refer to the Document de Référence filed with the Autorité des marchés financiers ( AMF ) on April 7, 2014, available on the AMF s website ( and on the Company s website ( Such documents may not be necessarily up to date. This document and the information contained herein do not constitute an offer to sell or a solicitation of an offer to buy or subscribe to shares of the Company in any country. Page 2

3 Innate Pharma at a glance Leading scientific edge in innate immunity pharmacology First-in-class immunomodulating antibodies targeting innate immunity Portfolio of first-in-class immunomodulating mabs Primary focus in immunooncology Potential for developments in chronic Inflammation Page 3

4 NK cell activation improves survival in AML patients Following allo-transplantation, NK cells protect against tumor relapse in AML patients NK activation NK inhibition Effects are: Durable Safe Controlled by KIR Mediated by NK cells Ruggeri et al, Blood, 2007 Page 4

5 Innate Pharma s pipeline PROGRAM TARGET INDICATION Valid PC PI PII PIII Lirilumab (IPH2102/BMS ) licensed to Bristol-Myers Squibb KIR2DL1,2,3 Acute Myeloid Leukemia Solid tumors, comb. with ipilimumab Solid tumors, comb. with nivolumab IPH2201 NKG2A Cancer IPH4102 KIR3DL2 Cutaneous T-cell lymphomas IPH33 TLR3 Inflammation / Autoimmunity IPH43 MICA Cancer Page 5

6 Innate Pharma positioning in immuno-oncology Clinical pipeline of immunomodulating antibodies in cancer TARGET PHASE I PHASE II PHASE III MARKET Inhibitory receptors CTLA-4 AZN BMS PD-1 / PD-L1 Merck KGaA, AZN, AMP/GSK, BMS BMS, Merck, Roche, AZN KIR IPH/BMS LAG-3 BMS IMP NKG2A IPH Activating receptors CD137 Pfizer BMS CSF-1R B7-H3 CD40 OX40 GITR CD27 AMG, LLY, Roche Servier/MGNX CRUK, Roche AZN GITR Inc, Merck Celldex Page 6

7 Lirilumab Page 7

8 First-in-class NK cell checkpoint inhibitor Fully human antibody blocking NK cell inhibitory receptor KIR2DL1/2/3 (IgG4) MHC class I KIR receptor - o Blocks interaction with MHC class 1 molecules Stressed cell Activating ligand NK Cell + Activating receptor KIR signaling inhibits NK cell Development and commercialization rights licenced to Bristol-Myers Squibb in 2011 o $35 million upfront, up to $430 million in milestone payments, double-digit royalties Stressed cell NK Cell + KIR-blockade allows NK activation Page 8

9 Intergroup ALFA/Goelams EFFIKIR Phase II trial Double-blind placebo-controled randomized trial of lirilumab in AML First randomized Phase II of lirilumab Sponsored by Innate 1:1:1 Elderly CR1 Max 2 consolidations Not eligible for HST Minimization Center 1º vs 2 nd AML No. consolidations Cytogenetics R A N D O M I Z E Lirilumab 0.1 mg/kg q 12 weeks Intermittent full KIR occupancy Lirilumab 1.0 mg/kg q 4 weeks Continuous full KIR occupancy Placebo q 4 weeks Treatment for 2 years Primary endpoint: Leukemia-Free Survival (Independent Review Committee) N=50 per arm (100 events) for overall α at 0.05 one-sided and power of 0.80, assuming median LFS of 12 months in the control group vs. 20 months in the treatment groups Recruitment period: months; Maximum follow-up period: 24 months after last patient entry Page 9

10 Phase I study of lirilumab in combination with nivolumab Patients with advanced solid tumors Dose escalation completed Cohort expansion in various solid tumors: > Nivolumab 3mg/kg, every other weeks and lirilumab 3mg/kg, every four weeks > Patients dosed for up to two years Participating centers (USA): > Memorial Sloan-Kettering Cancer Center, New York, NY > Dana-Farber Cancer Institute, Boston, MA > University of Chicago Comprehensive Cancer Center, Chicago, IL > Johns Hopkins Comprehensive Cancer Center, Baltimore, MD > Providence Portland Medical Center, Portland, OR Estimated enrollment: Page 10

11 Phase I study of lirilumab in combination with ipilimumab Patients with advanced solid tumors Regimen schedule: concurrent administration q3 weeks x 4 then q12 weeks x 4 Dose escalation: observation period of 9 weeks after first cycle Dosage during dose escalation Dose level number Total number of patients Cohort expansion: > Treat at the MTD or maximum administered dose Indications: > Non-small cell lung cancer > Castrate resistant prostate cancer > Melanoma Lirilumab, mg/kg Ipilimumab, mg/kg Total Participating centers (USA) > Memorial Sloan-Kettering Cancer Center, New York, NY > Dana-Farber Cancer Institute, Boston, MA > Ohio State University, Columbus, OH > Sarah Cannon Research Institute/ Tennessee Oncology, Nashville, TN > Moffitt Cancer Center, Tampa, FL > Masonic Cancer Center, University of Minnesota, MN Page 11

12 Lirilumab enhances efficacy of rituximab KIR blockade enhances ADCC function of NK cells in vivo and in vitro Kohrt et al., Blood, 2013 Page 12

13 IPH2201, anti-nkg2a Page 13

14 NKG2A: a checkpoint receptor on infiltrating NK and T cells NK cell CD8+ T cell Effector functions Effector functions NKG2D NKp CD94/NKG2A TCR + - CD94/NKG2A CD8 MIC-A??? HLA-E HLA-A, B (C, E) HLA-E Target cell (tumor or infected cell, stressed cell in chronic inflammation) Page 14

15 Potential for development of IPH2201 in diverse types of hematological and solid tumors HLA-E upregulated on a wide variety of tumor types; can correlate with poor prognosis Internal data Page 15

16 Phase II ready Dose-escalation safety trial conducted by Novo Nordisk A/S o 92 pts, moderate RA, low-dose MTX o IV single dose (SD, up to 10 mg/kg) and SC SD and MD (up to 4 mg/kg) o No safety issues identified, MTD not reached, no DLT Favorable safety profile, and first-in-class target, suggest wide potential for combination therapy Page 16

17 IPH2201 initial development plan H&N Phase 2 single agent H&N Phase 2 combo cetuximab CLL Phase 2 combo ibrutinib Ovarian Phase 2 single agent Ovarian Phase 2 combo SOC Page 17

18 Portfolio of first-in-class therapeutic mabs with diverse MOAs Compound Ab type MOA Anti-KIR2DL1/2/3 IgG4 Activate NK cells Anti-NKG2A IgG4 Activate NK and CD8+ T cells Anti-KIR3DL2 IgG1 ADCC, target tumor antigen Rare disease Anti-TLR3 IgG4 Blocking inflammation Anti-MICA Other targets ADC technology TBD ADCC, target tumor antigen Modulating NK cells Beyond I-O Beyond Cancer Beyond NK cells Page 18

19 Corporate information Cash on hand: 37.2 million at March 31, 2014 Listed on Euronext, IPO in November 2006 Euronext Paris: FR IPH 128m raised since inception Stock liquidity (in 2013) 46.7m outstanding shares (48.1m diluted) Average daily trading volume > Analyst coverage: Goldman Sachs, Leerink, Gilbert Dupont 55.3% Shareholders Novo Nordisk A/S * BPI Groupe * 11.1% 5.9% 2.6% 10.4% 8.8% 5.9% Wellington Management Company OrbiMed Fidelity Management Management Other/Autre * Shareholders represented at the Supervisory Board Page 19

20 Investor relations Laure-Hélène Mercier Director, Investor relations Tel: +33 (0) Fax: +33 (0) Page 20

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