International Journal of Scientific & Engineering Research, Volume 8, Issue 8, August-2017 ISSN ,956
|
|
- Dennis Byrd
- 6 years ago
- Views:
Transcription
1 1,956 Differences in survival by race/ethnicity among cutaneous melanoma patients in the United States over a period of thirty years ( ) Abdulrahman M Nasiri 1, Elharith S Al-Akeel 1. 1College of Medicine, Al Imam Mohammad Ibn Saud Islamic University (IMSIU), Riyadh, Saudi Arabia Abdulrahman M Nasiri, MBBS student College of Medicine Al Imam Mohammad Ibn Saud Islamic University (IMSIU) P.O.Box Riyadh Saudi Arabia nassri88@hotmail.com Elharith S Al-Akeel, MBBS student College of Medicine Al Imam Mohammad Ibn Saud Islamic University (IMSIU) P.O.Box Riyadh Saudi Arabia al.7areth@hotmail.com 2017
2 1,957 List of abbreviations: HR, hazard ratio CI, confidence interval IRB, institutional review board SEER: National Cancer Institute s Surveillance, Epidemiology, and End Result 2017
3 1,958 ABSTRACT Melanoma is an aggressive skin cancer with a high mortality rate. The incidence of melanoma has increased in recent years from 1:1500 in 1935 to 1:50 in The aim of this study is to investigate survival by race/ethnicity, taking site into account, among melanoma patients in the United States. This study is a secondary analysis of the Surveillance, Epidemiology, and End Results (SEER) Program. SEER collects data through a non-concurrent cohort study design. The sample size was participants. The chi-square test was used to examine the association between categorical variables. Kaplan-Meier survival analysis was used to estimate the overall survival curve and to estimate the survival curve per race/ethnicity. Collinearity was assessed using Pearson correlation. Cox proportional hazards regression was used to calculate the unadjusted and adjusted hazard ratios (HR). Non-Hispanic White (NHW) and Other patients were older in age (70 years or older), while non- Hispanic Black (NHB) and Hispanic patients were younger (30-39 years). Melanoma in NHW patients was mostly located in trunk whereas melanoma for NHB, Hispanic and Other patients was mostly located in the lower limbs. For all races/ethnicities except for NHB, more individuals were diagnosed between 2002 and Patients with melanoma in upper limbs lived more frequently. Fewer women died (6.8%) compared to men (17.1%). Patients who were diagnosed between the ages of were more likely to die. NHB had an adjusted HR of 3 (95% CI 2.7, 3.3) compared to NHW. The adjusted HR of lower limb was 1.6 (95% CI 1.5, 1,6) compared to the reference group (Head and Neck). The hazard for trunk and lower limb were about the same as the reference. Those who were 70 years or older had an adjusted HR of 2.2 (95% CI 2.0, 2.4). Women had an adjusted HR of 0.4 (95% CI 0.4, 0.5), and diagnosis during the decade had an adjusted HR of 2.6 (95% CI 2.4, 2.7). NHB patients and patients of ages years were more likely to die. The poorest survival was for diagnosis between 1982 and However, more individuals were diagnosed between 2002 and The lower limb had a worse prognosis with adjusted HR of 1.6 (95% CI 1.5, 1,6), and more men were diagnosed than women. 2017
4 1,959 INTRODUCTION Melanoma is an aggressive skin cancer, which affects pigment-producing cells called melanocytes 1. Although it accounts for only about 10% of skin cancer cases, melanoma has a high mortality rate. Furthermore, melanoma has different types, which affect different races and different sites 2. Unlike other types of cancers, the incidence of melanoma has increased in recent years 3. According to Sandru et al, the likelihood of getting melanoma increased from 1:1500 in 1935 to 1:50 in Lifetime risk of developing melanoma is related to internal and external factors. Internal factors that increase risk include genetics and age, while external factors include fair skin, red hair, light eyes, abundance of freckles, atypical moles or a large amount of moles 2. Fare skin, skin lesions, nevi and advanced age increase risk of developing melanoma. The Surveillance, Epidemiology, and End Results (SEER) database, a National Cancer Institute program that collects cancer and survival data of U.S. cancer patients, has also shown that the increase in incidence of melanoma varies among different areas and races/ethnicities. The incidence rate as found in SEER shows the highest incidence in Caucasians (19.1 females and 29.7 males per 100,000), followed by Hispanics (4.7 females and 4.4 males per 100,000), followed by Asians and Blacks (1.0 females and 1.1 males per 100,000) 4. These numbers are supported by another smaller study 7. Different sites of melanoma have different impact and prognosis. For example, in men, melanoma located on the scalp/neck has a worse prognosis and survival rate compared to other sites 5. In men the most frequent site of melanoma was the trunk, followed by the lower and upper extremities, while in women, the lower extremities were the predominant site. Common melanoma sites vary by race. Non-Hispanic Whites develop the lesion more frequently in the trunk and upper extremities, while African-Americans, Hispanics, and Asians develop the lesion more frequently in lower extremities 6. Many papers have studied the overall survival for melanoma patients of different races/ethnicities, but with different scopes. Some have studied a specific population while others focused on a 2017
5 1,960 specific state. Those who studied the overall survival of melanoma patients by race/ethnicity used a short period of follow-up time or did not analyze recent data. The aim of this study is to investigate survival by race/ethnicity, taking site into account, among melanoma patients in the United States over a period of 30 years ( ). This study will be important in determining whether there have been differences in the survival by race/ethnicity, which could influence the ways interventions for melanoma are targeted. METHODS This study is a secondary analysis of data from the SEER Program, which is the largest registry in the world to provide cancer statistics 6,7. SEER collects data through a non-concurrent cohort study design. The inclusion criteria for this study were adults 18 years or older with primary cutaneous melanoma located on head and neck, trunk, upper extremities or lower extremities who were diagnosed in the period of 1982 to 2011.The exclusion criteria were other cancers or sites, secondary lesions, multiple or unspecified melanoma sites, and patient less than 18 years. After excluding duplicate cases (n=20366), those who were less than 18 years (n=1300), those who received their diagnosis prior to 1982 (n=16426), and cases that were missing information related to survival (n=25864; 12.3%), the final sample size was participants. The variables included in the study were race, age at diagnosis, site, gender and year of diagnosis. Race/ethnicity was divided into four groups: non-hispanic White (NHW), non-hispanic black (NHB), Hispanic, and Other, which included Asian/Pacific Islander, American Indian/Alaska Native and other/unspecified. Age at diagnosis was grouped into six categories: under 30 years, 30 to 39, 40 to 49, 50 to 59, 60 to 69 and 70 and above 8. Site was classified into head and neck (H/N), trunk, upper limb (UL) and lower limb (LL). Eyelid and ears were considered part of the head and neck category. Both men and women were studied and year of diagnosis was grouped into three decades: , and Cross-tables were used to compare the different variables. The chi-square test was used to examine the association between categorical variables. A p-value of 0.05 was used as criteria to select confounders. Kaplan-Meier survival analysis was used to estimate the overall survival curve and to estimate the survival curves per race. Collinearity was assessed using Pearson correlation. Cox proportional hazards regression was used to calculate the unadjusted and adjusted hazard ratios 2017
6 1,961 (HR) and confidence interval (CI) of 95% was used to indicate the significance of the results. SPSS statistical package for Windows version 22 (IBM) was used to analyze the data. Ethical Review The present study using secondary analysis of anonymous data was exempt from IRB review by the FIU IRB under exemption category #4 ( Existing data, documents, and records specimens ). RESULTS Table 1 describes the demographic characteristics of U.S. adult patients with primary cutaneous melanoma in the period of NHW as well as Other patients with cutaneous melanoma tended to be older (70 years or older). NHB and Hispanic patientss with cutaneous melanoma tended to be younger (30-39 years). Melanoma was commonly located in the lower limbs for NHB, Hispanic and Other patients (43.2%, 28.9% and 28.5 respectively), while melanoma in NHW was located in the trunk (31%). Unlike other races/ethnicities, NHB men had a greater proportion of cutaneous melanoma than NHB women. More individuals were diagnosed in the last decade ( ) in all races except for NHB. Table 2 describes the associations between vital status and race, as well as other factors. All associations were significant. NHB were more likely to die compared with other races. Patients who were diagnosed between the ages of 30 to 39 were more likely to die. Patients with melanoma at UL lived more frequently. Fewer women died (6.8%) compared to men (17.1%). Only 5.2% of individuals diagnosed in died. No collinearity was observed in the adjusted model. The median follow up time was 81 month. Survival for each race was calculated using Kaplan-Meier analysis. Table 3 describes unadjusted and adjusted hazard ratios. NHB patients had an adjusted HR of 3 (95% CI 2.7, 3.3) compared to NHW patients; this HR decreased after adjustment. In the unadjusted model, individuals diagnosed between ages 30 to 39 years had an HR of 1.6 (95% CI 1.5, 1.7), while those 70 years or older had an HR of 1.2 (95% CI 1.1, 1.2). In the adjusted model, those 70 or older had a HR of 2.2 (95% CI 2.0, 2.4). In the unadjusted model, the HR for individuals diagnosed between ages 40 to 49 was not statistically significant; the estimate became significant in the adjusted model (HR=1.2; 95% 2017
7 1,962 CI 1.1, 1.3). The adjusted HR of lower limb was two times higher than that of other sites (HR=1.6; 95% CI 1.5, 1,6). Women had an adjusted HR of 0.4 (95% CI 0.4, 0.5), and diagnosis during the decade had an adjusted HR of 2.6 (95% CI 2.4, 2.7). DISCUSSION This study set out to examine differences in survival by race/ethnicity. NHB patients had 3 times the hazard of dying compared to NHW (HR=3; 95% CI 2.7, 3.3); this hazard was high even before adjusting for other variables (HR=4.3; 95% CI 4.0, 4.5). This finding is similar to that of other studies 6,9,10. In the unadjusted model, patients diagnosed between ages 30 to 39 years had an HR of 1.6 (95% CI 1.5, 1.7) in comparison to the reference group, but after adjusting this HR was closer to 1 (HR=1.4; 95% CI 1.3, 1.5) and increased for individuals diagnosed at 70 years or older (HR=2.2; 95% CI 2.0, 2.4). In the unadjusted model, the hazard ratios by site were similar to the reference group, but in the adjusted model the HR for lower limb increased to 1.6 (95% CI 1.5, 1,6). The sample for this study included 91.7% NHW, which was in contrast with most of the literature 11. There was an increase in the number of cases of cutaneous melanoma between The highest number of cutaneous melanoma cases was among NHW patients 70 years or older, which is similar to trends in a previous study conducted in ,13. When it comes to site, this study showed that NHW were more frequently diagnosed with melanoma in the trunk (31%), more than any site. In NHB and Hispanic patients, lower limb melanoma was more common (43.2% and 28.9%, respectively). This is similar to what Cormier et al found. However, the sample size in this study is larger and the observation period longer than what Cormier et al reported 14,15. More men had melanoma compared to women, and this was observed for men of all races (56.8% NHW, 71.9% NHB, 55.1% Hispanic & 56.5% Other), which is similar to findings in another study 16. Regarding decade of diagnosis, diagnosis from 1982 to 1991 had an adjusted HR of 2.6 (95% CI 2.4, 2.7) 17. One of the strengths of this study is the large population included, which enhances the external validity and applicability to the U.S. population. The secondary nature of this analysis may be considered a limitation. However, the data used were from SEER, which is a high-quality database that follows patients for a long period of time. One limitation was the loss of approximately 12% 2017
8 1,963 of cases due to missing information related to survival. However, this didn t affect the overall result because of the large sample size. Additionally, this study did not take variables such as frequency of outdoor activities, socioeconomic status, ulceration, tumor thickness and tumor width into account. Furthermore, this study did not differentiate sites in the head and neck. One article studied the head and neck in more details by splitting them into additional sites, which showed differences in prognosis 18,19. However, in other studies the head and neck were studied as one site 20. Finally, the follow up period was not equal among the three decades of diagnosis. For example, individuals diagnosed in 1982 had the longest possible follow up time, while individuals diagnosed in 2011 had the shortest length of follow up. CONCLUSION: In conclusion, this study showed that NHB patients had the poorest survival compared to other races. LL, which had a higher HR compared to other sites, was the most common melanoma site among NHB and Hispanic patients, while the trunk was the most common site for NHW patients. These findings add something valuable in the field of melanoma. References: 1. H. William Higgins II M, MBE,a Kachiu C. Lee, MD, MPH,a Anjela Galan, MD,c and David J. Leffell, MD. Melanoma in situ : Part I. Epidemiology, screening, and clinical features. J Am Acad Dermatol. 2011;73(2): Melanoma. Ferri's Clinical Advisor: Expert Consult; 2016: Edgar P. Simard P, MPH; Elizabeth M. Ward, PhD; Rebecca Siegel, MPH; Ahmedin Jemal, DVM, PhD. Cancers With Increasing Incidence Trends in theunited States: 1999 Through CA Cancer J Clin. 2012;62: Fisher EBHaDE. Melanoma Epidemiology, Risk Factors, and Clinical Phenotypes. InTech; Anne M. Lachiewicz MMB, PhD, MPH; Charles L. Wiggins, PhD, MSPH; Nancy E. Thomas, MD, PhD. Survival Differences Between Patients With Scalp or Neck Melanoma and Those With 2017
9 1,964 Melanoma of Other Sites in the Surveillance, Epidemiology, and End Results (SEER) Program. JAMA Dermatol. 2008;144(4): Jason A. Zell PC, Mehrdad Mobasher, Argyrios Ziogas, Frank L. Meyskens Jr, and Hoda Anton- Culver. Survival for Patients With Invasive Cutaneous Melanoma Among Ethnic Groups: The Effects of Socioeconomic Status and Treatment. J Clin Oncol. 2008;26(1): Institute TNC. The Surveillance, Epidemiology, and End Results (SEER) Program. Accessed Julay 28, Magnus Thorn H-OA, Ulrik Ringborg,: Reinhold Bergstrom, Ullabrith Krusemo. The Association Between Anatomic Site and Survival in Malignant Melanoma. An Analysis of 12,353 Cases from The Swedish Cancer Registry. Eur J Cancer Clin Oncol. 1988;25(3): Douglas S. Reintgen MKMM, Jr, MD, PhD; Edwin Cox, MD; Hilliard F. Seigler, MD. Malignant Melanoma in Black American and White American Populations. JAMA. 1982;248: Shasa Hu MRMS-V, PhD; Dorothy F. Parker, MHS; Robert S. Kirsner, MD, PhD. Comparison of Stage at Diagnosis of Melanoma Among Hispanic, Black, and White Patients in Miami-Dade County, Florida. Arch Dermatol. 2006; Crombie IK. Racial Differences In Melanoma Incidence. Br. J. Cancer. 1979;40: Eleni Linos SMS, Myles G. Cockburn, Graham A. Colditz and Christina A. Clarke. Increasing Burden of Melanoma in the United States. J Invest Dermatol. 2009;129: Ahmedin Jemal SSD, Patricia Hartge, Margaret A. Tucker. Recent Trends in Cutaneous Melanoma Incidence Among Whites in the United States. J Natl Cancer Inst. 2001;93(9): Janice N. Cormier M, MPH; Yan Xing, MD; Meichun Ding, PhD, et al. Ethnic Differences Among Patients With Cutaneous Melanoma. JAMA Intern Med. 2006; Rosemary D. Cress EAH. Incidence of cutaneous melanoma among non-hispanic Whites, Hispanics, Asians, and Blacks: an analysis of California Cancer Registry data, Cancer Causes and Control. 1997;8: Claus Garbe M, Ulrike Leiter, MD. Melanoma epidemiology and trends. Clin Dermatol. 2009;27(1): H. Irene Hall P, a Donald R. Miller, PhD,b Joseph D. Rogers, BS,a and Barbara Bewerse. Update on the incidence and mortality from melanoma in the United States. J Am Acad Dermatol. 1999;40:
10 1, Peter Gillgren MEM-B, MD; Jan Frisell, MD, PhD; Hemming Johansson, BA; Olle Larsson, MD, PhD; Ulrik Ringborg, MD, PhD. A Prospective Population-Based Study of Cutaneous Malignant Melanoma of the Head and Neck. Laryngoscope. 2000;110( ). 19. Claus Garbe MD, Petra Biiftner, Ph.D.,tJochen Bertz, M.D, et al. Primary cutaneous melanoma. Prognostic classification of anatomic location. Cancer. 1995;75(10): Xiao-Cheng Wu M, MPH,a Melody J. Eide, MD, MPH,b Jessica King, MPH (CDC), et al. Racial and ethnic variations in incidence and survival of cutaneous melanoma in the United States, J Am Acad Dermatol. 2011;
Racial differences in six major subtypes of melanoma: descriptive epidemiology
Wang et al. BMC Cancer (2016) 16:691 DOI 10.1186/s12885-016-2747-6 RESEARCH ARTICLE Racial differences in six major subtypes of melanoma: descriptive epidemiology Yu Wang 1, Yinjun Zhao 2 and Shuangge
More information1 Cancer Council Queensland, Brisbane, Queensland, Australia.
Title: Diagnosis of an additional in situ does not influence survival for patients with a single invasive : A registry-based follow-up study Authors: Danny R Youlden1, Kiarash Khosrotehrani2, Adele C Green3,4,
More informationSTUDY. A Trend Analysis of Melanoma Incidence and Stage at Diagnosis Among Whites, Hispanics, and Blacks in Florida
STUDY Disparity in Melanoma A Trend Analysis of Melanoma Incidence and Stage at Diagnosis Among Whites, Hispanics, and Blacks in Florida Shasa Hu, MD; Yisrael Parmet, PhD; Glenn Allen, MPH; Dorothy F.
More informationSTUDY. CME available online at
STUDY Survival Differences Between Patients With Scalp or Neck Melanoma and Those With Melanoma of Other Sites in the Surveillance, Epidemiology, and End Results (SEER) Program Anne M. Lachiewicz, MPH;
More informationEthnic disparities in melanoma diagnosis and survival
Ethnic disparities in melanoma diagnosis and survival The effects of socioeconomic status and health insurance coverage Amy M. Anderson-Mellies, MPH 1 Matthew J. Rioth, MD 1,2,3 Myles G. Cockburn, PhD
More informationTHE NEW ZEALAND MEDICAL JOURNAL
THE NEW ZEALAND MEDICAL JOURNAL Journal of the New Zealand Medical Association The incidence and thickness of cutaneous malignant melanoma in New Zealand 1994 2004 Ann Richardson, Lynn Fletcher, Mary Jane
More informationCitation for published version (APA): Huismans, A. (2015). Regional aspects of melanoma diagnosis and treatment [S.l.]: [S.n.]
University of Groningen Regional aspects of melanoma diagnosis and treatment Huismans, Annemarleen IMPORTANT NOTE: You are advised to consult the publisher's version (publisher's PDF) if you wish to cite
More informationSentinel Lymph Node Status is the Most Important Prognostic Factor in Patients With Melanoma of the Scalp
The Laryngoscope VC 2013 The American Laryngological, Rhinological and Otological Society, Inc. Sentinel Lymph Node Status is the Most Important Prognostic Factor in Patients With Melanoma of the Scalp
More informationCenters for Disease Control and Prevention (CDC)
American Cancer Society Ahmedin Jemal, DVM, PhD; Helmneh M. Sineshaw, MD, MPH Centers for Disease Control and Prevention (CDC) Manxia Wu, MD, MPH Florida Cancer Data System Brad Alan Wohler-Torres, MSc
More informationAnnual Report to the Nation on the Status of Cancer, , Featuring Survival Questions and Answers
EMBARGOED FOR RELEASE CONTACT: Friday, March 31, 2017 NCI Media Relations Branch: (301) 496-6641 or 10:00 am EDT ncipressofficers@mail.nih.gov NAACCR: (217) 698-0800 or bkohler@naaccr.org ACS Press Office:
More informationPoor prognosis for thin ulcerated melanomas and implications for a more aggressive approach to treatment
Poor prognosis for thin ulcerated melanomas and implications for a more aggressive approach to treatment Makenzie L. Hawkins, MSPH 1 Matthew J. Rioth, MD 1,2 Megan M. Eguchi, MPH 1 Myles Cockburn, Phd
More informationScarlett Gomez, MPH, PhD Cancer Prevention Institute of California NAACCR 2017 conference, Albuquerque NM June 2017
The influence of socioeconomic status and ethnic enclave on endometrial cancer mortality among Hispanic and Asian American/Pacific Islander women in California Scarlett Gomez, MPH, PhD Cancer Prevention
More informationAn Overview of Survival Statistics in SEER*Stat
An Overview of Survival Statistics in SEER*Stat National Cancer Institute SEER Program SEER s mission is to provide information on cancer statistics in an effort to reduce the burden of cancer among the
More informationSurvival Inequalities among Children, Adolescents and Young Adults with Acute Leukemia in California Renata Abrahão, MD MSc PhD
Survival Inequalities among Children, Adolescents and Young Adults with Acute Leukemia in California Renata Abrahão, MD MSc PhD California Cancer Registrars Association Sacramento November 3 rd, 2016 Objectives
More informationTB EPIDEMIOLOGY. Outline. Estimated Global TB Burden, TB epidemiology
TB EPIDEMIOLOGY TB Clinical Intensive Course Curry International Tuberculosis Center September 30, 2015 Varsha Nimbal, MPH Tuberculosis Control Branch California Department of Public Health 1 Outline TB
More informationIdentifying Geographic & Socioeconomic Disparities in Access to Care for Pediatric Cancer Patients in Texas
Identifying Geographic & Socioeconomic Disparities in Access to Care for Pediatric Cancer Patients in Texas Mary T. Austin, MD, MPH Assistant Professor, Pediatric Surgery University of Texas Health Science
More informationTreatment disparities for patients diagnosed with metastatic bladder cancer in California
Treatment disparities for patients diagnosed with metastatic bladder cancer in California Rosemary D. Cress, Dr. PH, Amy Klapheke, MPH Public Health Institute Cancer Registry of Greater California Introduction
More informationCharacteristics, treatment patterns, and survival outcomes of primary GI melanoma cases compared to cutaneous melanoma, SEER:
Characteristics, treatment patterns, and survival outcomes of primary GI melanoma cases compared to cutaneous melanoma, SEER:1973-2015 Amanda Kahl, MPH Mary E. Charlton, PhD, Imran Hassan, MD, Paolo Goffredo,
More informationBreast Cancer Subtypes Defined by HR/HER2 among Black Cases in the US by Birthplace
NAACCR 2018 Annual Conference Breast Cancer Subtypes Defined by HR/HER2 among Black Cases in the US by Birthplace Hyuna Sung, PhD; Carol Desantis, MPH; Stacey Fedawa, PhD; Ahmedin Jemal, DVM, PhD Surveillance
More informationMalignant Fibrous Histiocytoma: Database Review Suggests a Favorable Prognosis in the Head and Neck
The Laryngoscope VC 2017 The American Laryngological, Rhinological and Otological Society, Inc. Malignant Fibrous Histiocytoma: Database Review Suggests a Favorable Prognosis in the Head and Neck Robert
More informationUsing Cancer Registry Data to Estimate the Percentage of Melanomas Attributable to UV Exposure
Using Cancer Registry Data to Estimate the Percentage of Melanomas Attributable to UV Exposure Meg Watson, MPH Epidemiologist NAACCR Annual Conference June 16, 2016 National Center for Chronic Disease
More informationTemporal Trends in Demographics and Overall Survival of Non Small-Cell Lung Cancer Patients at Moffitt Cancer Center From 1986 to 2008
Special Report Temporal Trends in Demographics and Overall Survival of Non Small-Cell Lung Cancer Patients at Moffitt Cancer Center From 1986 to 2008 Matthew B. Schabath, PhD, Zachary J. Thompson, PhD,
More informationMorphologic characteristics of nevi associated with melanoma: a clinical, dermatoscopic and histopathologic analysis
DERMATOLOGY PRACTICAL & CONCEPTUAL www.derm101.com Morphologic characteristics of nevi associated with melanoma: a clinical, dermatoscopic and histopathologic analysis Temeida Alendar 1, Harald Kittler
More informationSTUDY. Incidence and Survival Patterns in the United States,
STUDY Acral Lentiginous Melanoma Incidence and Survival Patterns in the United States, 1986-2005 Porcia T. Bradford, MD; Alisa M. Goldstein, PhD; Mary L. McMaster, MD; Margaret A. Tucker, MD Objective:
More informationFACTORS ASSOCIATED WITH NEVUS VOLATILITY IN EARLY ADOLESCENCE
FACTORS ASSOCIATED WITH NEVUS VOLATILITY IN EARLY ADOLESCENCE The Harvard community has made this article openly available. Please share how this access benefits you. Your story matters Citation Oliveria,
More informationPopulation Based Survival of Female Breast Cancer Cases in Riyadh Region, Saudi Arabia
RESEARCH COMMUNICATION Population Based Survival of Female Breast Cancer Cases in Riyadh Region, Saudi Arabia K Ravichandran 1, Nasser Al Hamdan 2, Abdul Rahman Al Dyab 3 Abstract Breast cancer is the
More informationPatient age and cutaneous malignant melanoma: Elderly patients are likely to have more aggressive histological features and poorer survival
MOLECULAR AND CLINICAL ONCOLOGY 7: 1083-1088, 2017 Patient age and cutaneous malignant melanoma: Elderly patients are likely to have more aggressive histological features and poorer survival FARUK TAS
More informationSTUDY. Anatomic Distribution of Malignant Melanoma on the Non-Hispanic Black Patient,
STUDY Anatomic Distribution of Malignant Melanoma on the Non-Hispanic Black Patient, 1998-2007 Zachary M. Myles, MPH; Natasha Buchanan, PhD; Jessica B. King, MPH; Simple Singh, MD, MPH; Arica White, PhD,
More informationARTICLE. Epidemiology of melanoma in situ in New Zealand: Sam Rice, Lifeng Zhou, Richard Martin ABSTRACT
Epidemiology of melanoma in situ in New Zealand: 2008 2012 Sam Rice, Lifeng Zhou, Richard Martin ABSTRACT AIM: The incidence of melanoma in situ varies throughout the world. It is associated with excellent
More informationAnnual Report to the Nation on the Status of Cancer, , with a Special Feature Regarding Survival
University of Nebraska - Lincoln DigitalCommons@University of Nebraska - Lincoln Public Health Resources Public Health Resources 7-1-2004 Annual Report to the Nation on the Status of Cancer, 1975 2001,
More informationEpidemiology DATA AND METHODS
British Journal of Cancer () 9, 91 9 All rights reserved 7 9/ $3. www.bjcancer.com Recent trends in cutaneous malignant melanoma in the Yorkshire region of England; incidence, mortality and survival in
More informationAnnual Report to the Nation on the Status of Cancer, , Featuring Survival
JNCI J Natl Cancer Inst (217) 19(9): djx3 doi: 1.193/jnci/djx3 First published online March 31, 217 Article Annual Report to the Nation on the Status of Cancer, 1975 214, Featuring Survival Ahmedin Jemal,
More informationColorectal Cancer Demographics and Survival in a London Cancer Network
Cancer Research Journal 2017; 5(2): 14-19 http://www.sciencepublishinggroup.com/j/crj doi: 10.11648/j.crj.20170502.12 ISSN: 2330-8192 (Print); ISSN: 2330-8214 (Online) Colorectal Cancer Demographics and
More informationChildhood brain tumors in California
Childhood brain tumors in California Danielle N. Rodriguez, MPH Eric Stewart, BA Cancer Registry of Greater California Agenda Background Methods of Analysis Results Discussion Future Directions Background
More informationLife expectancy in the United States continues to lengthen.
Reduced Mammographic Screening May Explain Declines in Breast Carcinoma in Older Women Robert M. Kaplan, PhD and Sidney L. Saltzstein, MD, MPH wz OBJECTIVES: To examine whether declines in breast cancer
More informationEthnic Disparities in the Treatment of Stage I Non-small Cell Lung Cancer. Juan P. Wisnivesky, MD, MPH, Thomas McGinn, MD, MPH, Claudia Henschke, PhD,
Ethnic Disparities in the Treatment of Stage I Non-small Cell Lung Cancer Juan P. Wisnivesky, MD, MPH, Thomas McGinn, MD, MPH, Claudia Henschke, PhD, MD, Paul Hebert, PhD, Michael C. Iannuzzi, MD, and
More informationNIH Public Access Author Manuscript Cancer Epidemiol Biomarkers Prev. Author manuscript; available in PMC 2011 January 1.
NIH Public Access Author Manuscript Published in final edited form as: Cancer Epidemiol Biomarkers Prev. 2010 January ; 19(1): 144 147. doi:10.1158/1055-9965.epi-09-0807. Feasibility Study for Collection
More informationCUTANEOUS MALIGNANT MELANOMA AMONG WHITE HISPANICS AND NON-HISPANICS
CUTANEOUS MALIGNANT MELANOMA AMONG WHITE HISPANICS AND NON-HISPANICS IN THE UNITED STATES Aim: To explore whether disparities exist in melanoma incidence and prognosis between White Hispanics and White
More informationAn Overview of Melanoma. Harriet Kluger, M.D. Associate Professor Section of Medical Oncology Yale Cancer Center
An Overview of Melanoma Harriet Kluger, M.D. Associate Professor Section of Medical Oncology Yale Cancer Center Melanoma Statistics Median age at presentation 45-55 55 years Incidence: 2003 54,200 cases
More informationPopulation-based Patterns of HIV-related Hodgkin Lymphoma in the Greater San Francisco Bay Area:
Population-based Patterns of HIV-related Hodgkin Lymphoma in the Greater San Francisco Bay Area: 1988-98 Sally Glaser, Ph.D. Christina Clarke, Ph.D. Northern California Cancer Center Margaret Gulley, M.D.
More informationUpdates on the Conflict of Postoperative Radiotherapy Impact on Survival of Young Women with Cancer Breast: A Retrospective Cohort Study
International Journal of Medical Research & Health Sciences Available online at www.ijmrhs.com ISSN No: 2319-5886 International Journal of Medical Research & Health Sciences, 2017, 6(7): 14-18 I J M R
More informationGreater Atlanta Affiliate of Susan G. Komen Quantitative Data Report
Greater Atlanta Affiliate of Susan G. Komen Quantitative Data Report 2015-2019 Contents 1. Purpose, Intended Use, and Summary of Findings... 4 2. Quantitative Data... 6 2.1 Data Types... 6 2.2 Breast Cancer
More informationCutaneous Melanoma: Epidemiology (USA) The Sentinel Node in Head and Neck Melanoma. Cutaneous Melanoma: Epidemiology (USA)
The Sentinel Node in Head and Neck Melanoma Cutaneous Melanoma: Epidemiology (USA) 6 th leading cause of cancer among men and women 68,720 new cases of invasive melanoma in 2009 8,650 deaths from melanoma
More informationNAACCR CINA Database Studies
IRB # Study 03-01 2003-Urban-rural variation in the incidence of selected cancer sites, United States, 1995-1999. 1995-1999 Holly Howe Terminated Standard 6 /1 /2005 03-02 2003-Mini-Proposal: Urban-Rural
More informationDermatofibrosarcoma protuberans (DFSP) is
Incidence and Survival of Primary Dermatofibrosarcoma Protuberans in the United States Kathryn L. Kreicher, BA,* David E. Kurlander, MD, Haley R. Gittleman, MS, Jill S. Barnholtz-Sloan, PhD, and Jeremy
More informationTrends in Cancer CONS Disparities between. W African Americans and Whites in Wisconsin. Carbone Cancer Center. July 2014
Photo Illustration by Lois Bergerson/UW SMPH Media Solutions Trends in Cancer CONS IN IS Disparities between W s and s in Wisconsin July 214 Carbone Cancer Center Dane County Cancer Profile 214 UNIVERSITY
More informationRetention in HIV care predicts subsequent retention and predicts survival well after the first year of care: a national study of US Veterans
Retention in HIV care predicts subsequent retention and predicts survival well after the first year of care: a national study of US Veterans Thomas P. Giordano, MD, MPH, Jessica A. Davila, PhD, Christine
More informationSurvival Comparison of Adenosquamous, Squamous Cell, and Adenocarcinoma of the Lung After Lobectomy
Survival Comparison of Adenosquamous, Squamous Cell, and Adenocarcinoma of the Lung After Lobectomy David T. Cooke, MD, Danh V. Nguyen, PhD, Ying Yang, MS, Steven L. Chen, MD, MBA, Cindy Yu, MD, and Royce
More informationSurvival Difference between Non-Hispanic Black and Non-Hispanic White Women with Localized Breast Cancer: The Impact of Guideline-Concordant Therapy
o r i g i n a l c o m m u n i c a t i o n Survival Difference between Non-Hispanic Black and Non-Hispanic White Women with Localized Breast Cancer: The Impact of Guideline-Concordant Therapy Xiaocheng
More informationAssociated Detection Patterns, Lesion Characteristics, and Patient Characteristics
1562 Thin Primary Cutaneous Melanomas Associated Detection Patterns, Lesion Characteristics, and Patient Characteristics Jennifer L. Schwartz, M.D. 1 Timothy S. Wang, M.D. 1 Ted A. Hamilton, M.S. 1 Lori
More informationDuring the past 2 decades, an increase in the ageadjusted
CLINICAL GASTROENTEROLOGY AND HEPATOLOGY 2006;4:104 110 Racial Differences in Survival of Hepatocellular Carcinoma in the United States: A Population-Based Study JESSICA A. DAVILA* and HASHEM B. EL SERAG*,
More informationMelanoma Thickness Trends in the United States,
ORIGINAL ARTICLE in the United States, 26 Vincent D. Criscione 1,2 and Martin A. Weinstock 1,2 Over the past two decades, numerous efforts have been initiated to improve screening and early detection of
More informationCutaneous Melanoma Incidence and Survival Among Black, Asian and Pacific Islander and White Populations in the United States
Clinical Medicine Insights: Dermatology Original Research Open Access Full open access to this and thousands of other papers at http://www.la-press.com. Cutaneous Melanoma Incidence and Survival Among,
More informationThe effect of delayed adjuvant chemotherapy on relapse of triplenegative
Original Article The effect of delayed adjuvant chemotherapy on relapse of triplenegative breast cancer Shuang Li 1#, Ding Ma 2#, Hao-Hong Shi 3#, Ke-Da Yu 2, Qiang Zhang 1 1 Department of Breast Surgery,
More informationHIV/AIDS IN MIAMI-DADE COUNTY THROUGH 2015
HIV/AIDS IN MIAMI-DADE COUNTY THROUGH 2015 Florida Department of Health in Miami-Dade County, Epidemiology, Disease Control & Immunization Services, HIV/AIDS Surveillance Unit By Rodolfo Boucugnani Please
More informationAdjuvant Chemotherapy for Patients with Stage III Colon Cancer: Results from a CDC-NPCR Patterns of Care Study
COLON CANCER ORIGINAL RESEARCH Adjuvant Chemotherapy for Patients with Stage III Colon Cancer: Results from a CDC-NPCR Patterns of Care Study Rosemary D. Cress 1, Susan A. Sabatino 2, Xiao-Cheng Wu 3,
More informationTrends in HPV-Associated Cancers United States,
National Center for Chronic Disease Prevention and Health Promotion Trends in HPV-Associated Cancers United States, 1999 2014 Elizabeth A. Van Dyne, MD, MPH Division of Cancer Prevention and Control Epidemiology
More informationColumbus Affiliate of Susan G. Komen Quantitative Data Report
Columbus Affiliate of Susan G. Komen Quantitative Data Report 2015-2019 Contents 1. Purpose, Intended Use, and Summary of Findings... 4 2. Quantitative Data... 6 2.1 Data Types... 6 2.2 Breast Cancer Incidence,
More informationSurvival among Native American Adolescent and Young Adult Cancer Patients in California
Survival among Native American Adolescent and Young Adult Cancer Patients in California Cyllene R. Morris, 1 Yi W. Chen, 1 Arti Parikh-Patel, 1 Kenneth W. Kizer, 1 Theresa H. Keegan 2 1 California Cancer
More informationIncidence of Primary Liver Cancer in American Indians and Alaska Natives
Incidence of Primary Liver Cancer in American Indians and Alaska Natives Stephanie C. Melkonian, PhD Epidemiologist Epidemiology and Applied Research Branch NAACCR Annual Conference June 21, 2017 Overview
More informationHormone receptor and Her2 neu (Her2) analysis
ORIGINAL ARTICLE Impact of Triple Negative Phenotype on Breast Cancer Prognosis Henry G. Kaplan, MD* and Judith A. Malmgren, PhD à *Swedish Cancer Institute at Swedish Medical Center; HealthStat Consulting
More information6/20/2012. Co-authors. Background. Sociodemographic Predictors of Non-Receipt of Guidelines-Concordant Chemotherapy. Age 70 Years
Sociodemographic Predictors of Non-Receipt of Guidelines-Concordant Chemotherapy - among Locoregional Breast Cancer Patients Under Age 70 Years Xiao-Cheng Wu, MD, MPH 2012 NAACCR Annual Conference June
More informationMiami-Dade County HIV/AIDS Epidemiological Data. July 8, 2010
Miami-Dade County HIV/AIDS Epidemiological Data July 8, 21 Data provided by the Florida Department of Health HIV/AIDS Surveillance Program Prepared by Behavioral Science Research EPI DATA HELPS US Fulfill
More information10-Year Mortality of Older Acute Myocardial Infarction Patients Treated in U.S. Community Practice
10-Year Mortality of Older Acute Myocardial Infarction Patients Treated in U.S. Community Practice Ajar Kochar, MD on behalf of: Anita Y. Chen, Puza P. Sharma, Neha J. Pagidipati, Gregg C. Fonarow, Patricia
More informationChanges in Caries in Primary Dentition from to Among U.S. Children Aged 2-5 Years: A Closer Look
Changes in Caries in Primary Dentition from 1988-1994 to 1999-2004 Among U.S. Children Aged 2-5 Years: A Closer Look Laurie Barker, MSPH Mathematical Statistician Presenting for Mei Lin, MD, MPH, MS, Epidemiologist
More informationWisconsin Cancer Health Disparities Surveillance Reports: Trends in Cancer Disparities Among African Americans and Whites in Wisconsin
Wisconsin Cancer Health Disparities Surveillance Reports: s in Cancer Disparities Among s and s in Wisconsin 29 1 Authors: Nathan R. Jones, PhD 1,2 Amy A. Williamson, MPP 1,2 Paul D. Creswell, BA 1,2 Rick
More informationBurden of Cancer in California
Burden of Cancer in California California Cancer Reporting and Epidemiologic Surveillance Institute for Population Health Improvement UC Davis Health August 22, 2018 Outline 1. Incidence and Mortality
More informationWe have no disclosures
Pulmonary Artery Pressure Changes Differentially Effect Survival in Lung Transplant Patients with COPD and Pulmonary Hypertension: An Analysis of the UNOS Registry Kathryn L. O Keefe MD, Ahmet Kilic MD,
More informationMelanoma Surveillance in the United States: Overview of Methods
Melanoma Surveillance in the United States: Overview of Methods Meg Watson, MPH Epidemiologist Epidemiology and Applied Research Branch Division of Cancer Prevention and Control Centers for Disease Control
More informationImpact of Screening Colonoscopy on Outcomes in Colon Cancer Surgery
Impact of Screening Colonoscopy on Outcomes in Colon Cancer Surgery The Harvard community has made this article openly available. Please share how this access benefits you. Your story matters. Citation
More informationNorth Carolina Triangle to the Coast Affiliate of Susan G. Komen Quantitative Data Report
North Carolina Triangle to the Coast Affiliate of Susan G. Komen Quantitative Data Report 2015-2019 Contents 1. Purpose, Intended Use, and Summary of Findings... 4 2. Quantitative Data... 6 2.1 Data Types...
More informationHIV and Syphilis Co-Infection in Maricopa County
HIV and Syphilis Co-Infection in Maricopa County Item Type Thesis Authors Thomas, Sarah Rights Copyright is held by the author. Digital access to this material is made possible by the College of Medicine
More informationAanvraag gegevens ten behoeve van wetenschappelijk onderzoek
Aanvraag gegevens ten behoeve van wetenschappelijk onderzoek Registatie waarvan gegevens worden opgevraagd: NBCA Contactpersoon Nederland: Naam: Dr. A.C.M. van Bommel of Dr. H.A. Rakhorst Centrum/Ziekenhuis:
More informationChibueze Onyemkpa 1, Alan Davis 1, Michael McLeod 1, Tolutope Oyasiji 1,2. Original Article
Original Article Typical carcinoids, goblet cell carcinoids, mixed adenoneuroendocrine carcinomas, neuroendocrine carcinomas and adenocarcinomas of the appendix: a comparative analysis of survival profile
More informationBreast Cancer Statistics, 2017, Racial Disparity in Mortality by State
CA CANCER J CLIN 2017;67:439 448 Breast Cancer Statistics, 2017, Racial Disparity in Mortality by State Carol E. DeSantis, MPH 1 ; Jiemin Ma, PhD 2 ; Ann Goding Sauer, MSPH 3 ; Lisa A. Newman, MD, MPH
More informationBreast Cancer in Women from Different Racial/Ethnic Groups
Cornell University Program on Breast Cancer and Environmental Risk Factors in New York State (BCERF) April 2003 Breast Cancer in Women from Different Racial/Ethnic Groups Women of different racial/ethnic
More informationSusan G. Komen Tri-Cities Quantitative Data Report
Susan G. Komen Tri-Cities Quantitative Data Report 2014 Contents 1. Purpose, Intended Use, and Summary of Findings... 4 2. Quantitative Data... 6 2.1 Data Types... 6 2.2 Breast Cancer Incidence, Death,
More informationTable of Contents. 2 P age. Susan G. Komen
NEVADA Table of Contents Table of Contents... 2 Introduction... 3 About... 3 Susan G. Komen Affiliate Network... 3 Purpose of the State Community Profile Report... 4 Quantitative Data: Measuring Breast
More informationA DISSERTATION SUBMITTED TO THE FACULTY OF THE GRADUATE SCHOOL OF THE UNIVERSITY OF MINNESOTA BY. Helen Mari Parsons
A Culture of Quality? Lymph Node Evaluation for Colon Cancer Care A DISSERTATION SUBMITTED TO THE FACULTY OF THE GRADUATE SCHOOL OF THE UNIVERSITY OF MINNESOTA BY Helen Mari Parsons IN PARTIAL FULFILLMENT
More information2017 HIV/AIDS Epidemiology Update 2016 Data. James Dowling Health Program Coordinator Division of Public Health
2017 HIV/AIDS Epidemiology Update 2016 Data James Dowling Health Program Coordinator Division of Public Health Primary Sources Evaluation HIV/AIDS Reporting System (EHARS) Collects infection data from
More informationCalifornia Medicaid Enrollment and Melanoma Stage at Diagnosis A Population-Based Study
California Medicaid Enrollment and Melanoma Stage at Diagnosis A Population-Based Study Ricardo A. Pollitt, PhD, Christina A. Clarke, PhD, MPH, Sarah J. Shema, MS, Susan M. Swetter, MD Background: Methods:
More informationResearch Article Clinical Features and Outcomes Differ between Skeletal and Extraskeletal Osteosarcoma
Sarcoma, Article ID 902620, 8 pages http://dx.doi.org/10.1155/2014/902620 Research Article Clinical Features and Outcomes Differ between and Osteosarcoma Sheila Thampi, 1 Katherine K. Matthay, 1 W. John
More informationImpacts of Early Exposure to Work on Smoking Initiation Among Adolescents and Older Adults: the ADD Health Survey. David J.
Impacts of Early Exposure to Work on Smoking Initiation Among Adolescents and Older Adults: the ADD Health Survey David J. Lee, PhD University of Miami Miller School of Medicine Department of Public Health
More informationWellness Coaching for People with Prediabetes
Wellness Coaching for People with Prediabetes PUBLIC HEALTH RESEARCH, PRACTICE, AND POLICY Volume 12, E207 NOVEMBER 2015 ORIGINAL RESEARCH Wellness Coaching for People With Prediabetes: A Randomized Encouragement
More informationThyroid Cancer in New Mexico
Thyroid Cancer in New Mexico Time Trends and Surgical Treatment Preferences Ihsan Mahdi MD MPH Introduction The incidence of thyroid cancer incidence is increasing more rapidly than any other malignancy
More informationSurgical resection improves survival in pancreatic cancer patients without vascular invasion- a population based study
Original article Annals of Gastroenterology (2013) 26, 346-352 Surgical resection improves survival in pancreatic cancer patients without vascular invasion- a population based study Subhankar Chakraborty
More informationLow birthweight and respiratory disease in adulthood: A population-based casecontrol
Page 26 of 36 Online Data Supplement Low birthweight and respiratory disease in adulthood: A population-based casecontrol study Eric C. Walter, MD; William J. Ehlenbach, MD; David L. Hotchkin, MD, Jason
More informationPsychological factors associated with skin cancer detection behaviors in individuals with a family history of melanoma
University of South Florida Scholar Commons Graduate Theses and Dissertations Graduate School 2003 Psychological factors associated with skin cancer detection behaviors in individuals with a family history
More informationCancer Prevention Institute of California, Fremont, California. 2. Stanford Cancer Institute, Stanford, California. 3
How much of the racial/ethnic disparities in cancer survival in California is explained by differences in tumor, sociodemographic, institutional and neighborhood characteristics? Elizabeth Ellis 1,2, Alison
More informationCharacteristics of Philadelphia Census Tracts with High Prostate Cancer Risk
Characteristics of Philadelphia Census Tracts with High Prostate Cancer Risk Charnita Zeigler-Johnson, PhD, MPH Thomas Jefferson University Philadelphia, PA Using Cancer Registry Data in Disparities Research
More informationDEVELOPMENT OF MULTIPLE PRIMARY CANCERS IN LUNG CANCER PATIENTS: APPALACHIAN VS. NON-APPALACHIAN POPULATIONS OF KENTUCKY
University of Kentucky UKnowledge Theses and Dissertations--Public Health (M.P.H. & Dr.P.H.) College of Public Health 2016 DEVELOPMENT OF MULTIPLE PRIMARY CANCERS IN LUNG CANCER PATIENTS: APPALACHIAN VS.
More informationCDC HPV Typing of Cancers Study: Evaluating Representativeness
CDC HPV Typing of Cancers Study: Evaluating Representativeness NAACCR Annual Conference June 22, 2011 Meg Watson, MPH National Center for Chronic Disease Prevention and Health Promotion Division of Cancer
More informationCancer Statistics, 2008
CA Cancer J Clin 8;58:71 96 Cancer Statistics, 8 Ahmedin Jemal, DVM, PhD; Rebecca Siegel, MPH; Elizabeth Ward, PhD; Yongping Hao, PhD; Jiaquan Xu*, MD; Taylor Murray; Michael J. Thun, MD, MS ABSTRACT Each
More informationDemographics and Health Data
Demographics and Health Data Information for Local Planners City of Lakewood, WA Demographic Characteristics Environmental Health Division 3629 South D Street, Tacoma, WA 98418 (253) 798-6470 Table 1 presents
More informationRisk Factors in African-American Women. Michele L. Cote, PhD Associate Professor Wayne State t University
Risk Factors in African-American Women Michele L. Cote, PhD Associate Professor Wayne State t University it Age Adjusted Incidence and Mortality Rates for all Endometrial Cancers 2000-2010 by Race/Ethnicity
More informationDisparities in Progress against Cancer in the USA
Disparities in Progress against Cancer in the USA Ahmedin Jemal, DVM, PhD American Cancer Society ASPO Webinar November 29, 2018 Progress in reducing cancer death rates in the US, 1970-2015 240 220 215
More informationTHE BURDEN OF CANCER IN NEBRASKA: RECENT INCIDENCE AND MORTALITY DATA
THE BURDEN OF CANCER IN NEBRASKA: RECENT INCIDENCE AND MORTALITY DATA Presented by: Bryan Rettig, MS Nebraska Dept. of Health & Human Services Division of Public Health May 31, 2017 Nebraska Cancer Registry
More informationOUTCOME DISPARITIES BY AGE AND 21-GENE RECURRENCE SCORE RESULT IN HORMONE RECEPTOR-POSITIVE (HR+) BREAST CANCER
OUTCOME DISPARITIES BY AGE AND 21-GENE RECURRENCE SCORE RESULT IN HORMONE RECEPTOR-POSITIVE (HR+) BREAST CANCER Shak S, 1 Miller DP, 1 Howlader N, 2 Gliner N, 1 Howe W, 3 Schussler N, 3 Cronin K, 2 Baehner
More informationTrends in Basal Cell Carcinoma Incidence and Identification of High-Risk Subgroups,
Research Original Investigation Trends in Basal Cell Carcinoma Incidence and Identification of High-Risk Subgroups, 1998-2012 Maryam M. Asgari, MD, MPH; Howard H. Moffet, MPH; G. Thomas Ray, MBA; Charles
More information