16 TH -17 TH INNOVATIONS IN ONCOLOGY NOVEMBER HEIDELBERG

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1 16 TH -17 TH 2015 NOVEMBER INNOVATIONS IN ONCOLOGY HEIDELBERG

2 INNOVATIONS IN ONCOLOGY HEIDELBERG, NOVEMBER 16 TH - 17 TH 2015 German Cancer Research Center (DKFZ) Heidelberg - Germany Hosted by the National Center for Tumor Diseases (NCT) Heidelberg, the German Cancer Research Center (DKFZ), the Felix Burda Foundation and the German Network Against Colorectal Cancer, our 2015 Innovations in Oncology Workshop will bring together scientists and physicians from academics to industry to discuss the latest findings in cancer science and medicine. The workshop is designed to foster interdisciplinary communication and collaboration through an exciting range of sessions and panel discussions on Big Data in Genomic Analysis, Familial Risk of Cancer, Personalized Diagnostics for Targeted Therapies of Cancer and Innovative Therapeutic Approaches of Cancer Immunotherapy. We hope that you will join us at our Innovation Workshop on November, 16 th -17 th 2015 in the beautiful city of Heidelberg and strengthen our links in cancer research and medicine. The Organizing Committee Dr. Christa Maar CEO Felix Burda Foundation President of German Network Against Colorectal Cancer Dr. Georg Ralle General Secretary German Network Against Colorectal Cancer Prof. Dr. Christof von Kalle Director, Translational Oncology National Center for Tumor Diseases Prof. Dr. Dirk Jäger Director, Medical Oncology National Center for Tumor Dieseases

3 SATELLITE SYMPOSIUM* NOVEMBER 16 TH :30 12:00 Welcome Lunch 12:00-14:00 Session: Big Data in Genomic Analysis Challenges & Opportunities Chair: Gerd Maass / Christof von Kalle 12:00 12:20 Comprehensive genomic profiling in oncology clinical care and clinical trials Garrett Frampton, Foundation Medicine Inc., Cambridge 12:30 12:50 Real-time processing of genomic and clinical data Werner Eberhardt, SAP Deutschland SE & Co. KG, Walldorf 13:00 13:20 Engineering the medical revolution big data in clinical decision making Stephan Brock, Molecular Health GmbH, Heidelberg 13:30 13:50 Bioinformatics concepts for the molecular tumor board Benedikt Brors, DKFZ and National Center for Tumor Diseases (NCT), Heidelberg 14:00-14:30 Panel Discussion: Moderation: Gerd Maass Stephan Brock, Molecular Health GmbH, Heidelberg Benedikt Brors, DKFZ and National Center for Tumor Diseases (NCT), Heidelberg Werner Eberhardt, SAP Deutschland SE & Co. KG, Walldorf, Heidelberg Christof von Kalle, National Center for Tumor Diseases (NCT), Heidelberg Garrett Frampton, Foundation Medicine Inc., Cambridge 14:30 15:00 Coffee Break / Get Together *WITH FRIENDLY SUPPORT OF: (PROMOTION AND PRESENTATION) (3.000 ) (5.000 ) ( )

4 NOVEMBER 16 TH :00-15:15 Welcome Speech Christa Maar, German Network Against Colorectal Cancer, Munich Christof von Kalle, National Center for Tumor Diseases (NCT), Heidelberg 15:15-18:15 Session I: Familial Risk of Cancer Chairs: Rita Schmutzler / Christa Maar 15:15-15:35 How to predict breast cancer risk Douglas Easton, University of Cambridge, Cambridge 15:45 16:05 Stratification of breast cancer into 10 genomic driver-based subtypes and its implications Carlos Caldas, University of Cambridge, Cambridge 16:15 16:35 Challenges for the implementation of risk-stratified prevention Kerstin Rhiem, University Hospital Cologne, Cologne 16:45 17:15 Coffee Break 17:15 17:35 Hereditary colorectal cancer Jewel Samadder, Huntsman Cancer Institute, Salt Lake City 17:45 18:05 Better understanding family history of colorectal cancer to tailor screening recommendations Polly A. Newcomb, Fred Hutchinson Cancer Research Center, Seattle

5 NOVEMBER 16 TH :15-19:00 Panel Discussion I: Familial Risk of Cancer Moderation: Christina Berndt Hermann Brenner, German Cancer Research Center (DKFZ), Heidelberg Carlos Caldas, University of Cambridge, Cambridge Douglas Easton, University of Cambridge, Cambridge Christa Maar, German Network Against Colorectal Cancer, Munich Polly A. Newcomb, Fred Hutchinson Cancer Research Center, Seattle Kerstin Rhiem, University Hospital Cologne, Cologne Jewel Samadder, Huntsman Cancer Institute, Utah Rita Schmutzler, University Hospital Cologne, Cologne Barbara Zimmer, Competence Centre Oncology (KCO), Düsseldorf 19:00 20:00 Get Together at DKFZ 20:00 Speakers Dinner

6 NOVEMBER 17 TH :00-11:30 Session II: Personalized Diagnostics for Targeted Therapies of Cancer Chairs: Christof von Kalle / Tim Hubbard 08:00 08:20 The UK 100,000 genomes project: towards personalised health in the NHS Tim Hubbard, King s College, London 08:30 08:50 Blood biopsy as a window into tumor heterogeneity Jens G. Lohr, Dana-Farber Cancer Institute, Boston 09:00 09:20 Clinical implementation of cross-entity cancer genome sequencing Stefan Fröhling, National Center for Tumor Diseases (NCT), Heidelberg 09:30 09:50 Precision Medicine: the example of chronic lymphocytic leukemia Michael Hallek, Center for Integrated Oncology (CIO) Cologne/Bonn, University Hospital Cologne, Cologne 10:00 10:30 Coffee Break 10:30 10:50 CEA AND CYFRA21-1 IMPROVE THE SPECIFICITY OF A 29-GENE BLOOD-BASED TEST FOR EARLY DETECTION OF COLORECTAL CANCER Nichita Cristina, Lausanne University Hospital, Lausanne 11:00 11:20 Tumour-educated monocytes for diagnosis and disease follow-up of colorectal cancer Alexander Hamm, Heidelberg University Hospital, Heidelberg 11:30 11:45 Coffee Break

7 NOVEMBER 17 TH :45-13:00 Session III: Oncology Pipeline Chairs: Wolff Schmiegel / Georg Ralle 11:45 11:55 New medicines impacting lives of cancer patients Daniel Kalanovic, Pfizer Pharma GmbH, Berlin 12:00 12:10 Immuno-oncology by MSD: pembrolizumab and beyond Carine Keppens, MSD Sharp & Dohme GmbH, Haar 12:15 12:25 An insight into the Roche pipeline - an outlook into the future Jan Pintoffl, Roche Pharma AG, Grenzach-Wyhlen 12:30 12:40 Detection of neoplasia in the colorectum Impact of novel endoscopic techniques Alexander Dechêne, University Hospital Essen (on behalf of Olympus Deutschland GmbH), Hamburg 12:45 12:55 Innovations in colonoscopic colorectal cancer screening Friedrich Kilian, Heidelberg University Hospital, Heidelberg (on behalf of Norgine GmbH, Marburg) 13:00 14:00 Lunch

8 NOVEMBER 17 TH :00-17:00 Session IV: Innovative Therapeutic Approaches: Immunotherapy Chairs: Dirk Jäger / Ugur Sahin 14:00 14:20 Recent breakthroughs in immunotherapy of cancer Pedro Romero, Ludwig Center for Cancer Research, University of Lausanne, Lausanne 14:30 14:50 Immunotherapy for brain tumors Michael Platten, German Cancer Research Center (DKFZ) and National Center for Tumor Diseases (NCT), Heidelberg 15:00 15:20 Biomarker-supported development of an immune-effector-mobilizing antibody against a novel cancer cell surface target Özlem Türeci, Ganymed Pharmaceuticals AG, Mainz 15:30 16:00 Coffee Break 16:00 16:20 Engineering of chimeric antigen receptor (CAR)-modified T cells for immunotherapy of cancer Michael Hudecek, University Hospital Würzburg, Würzburg 16:30 16:50 The immune biology of DNA mismatch repair deficient cancer: basic concepts and clinical applications Magnus von Knebel Doeberitz, Heidelberg University Hospital, Heidelberg

9 NOVEMBER 17 TH :00-18:00 Panel Discussion II: Innovations in Oncology Moderation: Joachim Müller-Jung / Johannes Bruns Michael Hallek, Center for Integrated Oncology (CIO) Cologne/Bonn, University Hospital Cologne, Cologne Jan Helfrich, DAK-Gesundheit, Hamburg Ursula Marschall, BARMER GEK Krankenkasse, Berlin Hagen Pfundner, Roche Pharma AG, Grenzach-Wyhlen Wolff Schmiegel, Ruhr-University/German Cancer Society (DKG), Bochum 18:00 Get Together at DKFZ **WITH FRIENDLY SUPPORT OF (PROMOTION AND PRESENTATION): ( ) ( ) ( ) ( )

10 Hosted by: Location: German Cancer Research Center (DKFZ) Communication Center, Lecture Hall Im Neuenheimer Feld 280, Heidelberg Information and Registration: Viktoria Reinhardt Phone: +49 (0) Fax: +49 (0) Online Registration: Site Map: UniversitätsKlinikum Heidelberg Stand: Sept. 2015