Title: Synuclein Gamma Predicts Poor Clinical Outcome in Colon Cancer with Normal Levels of Carcinoembryonic Antigen

Size: px
Start display at page:

Download "Title: Synuclein Gamma Predicts Poor Clinical Outcome in Colon Cancer with Normal Levels of Carcinoembryonic Antigen"

Transcription

1 Author's response to reviews Title: Synuclein Gamma Predicts Poor Clinical Outcome in Colon Cancer with Normal Levels of Carcinoembryonic Antigen Authors: Caiyun Liu Bin Dong Aiping Lu Xiaofang Xing Like Qu Lin Meng Jian Jian Wu Eric Shi Chengchao Shou Version: 3 Date: 18 December 2009 Author's response to reviews: see over

2 Dear members of BioMed Central Editorial Team: We appreciate your kind consideration of our manuscript (No: ) and the valuable comments from the reviewers. We have revised the manuscript according to the reviewer s concerns point-to-point as below (Responses to the comments from the reviewers). For your convenience, both the original comments and questions are kept in this letter below. All the changes in the manuscript have also been highlighted by track-change function. We understand the significance for us to provide clarification and additional analysis for our data. We have done with our best to fulfill this goal. Please let us know if there are any additional questions and comments. Yours sincerely, Chengchao Shou, Ph.D, MD Professor and Director Department of Biochem & Mol Biol Peking University School of Oncology Beijing Cancer Hospital & Institute 52# Fu-Cheng road, Haidian district Beijing, , PRC Tel Fax: scc@bjcancer.org

3 Responses to the comments from the reviewers Reviewer 1: 1. Introduction: In colon cancer, CEA is mainly used as a marker for serial follow-up to detect tumor recurrence and progression rather than as a prognostic/predictive marker. The rationale to study synuclein as a prognostic marker in conjunction with serum CEA levels is therefore not clear. Thanks for what the reviewer concerned. The data from different labs about the utility of preoperative CEA in CRC remains controversial as regards to its application in the diagnosis, prognosis, and management and follow up of CRC patients. The preoperative CEA in CRC patients identifies subsets with favorable, indolent and uneven biological behavior (The cut-off for a positive CEA ranges from 3 to 15 ng/ml between the various studies) (Tan E, et al. Surg Oncol. 2009;18:15-24). Moreover, the addition of preoperative CEA level to conventional staging forms a strong prognostic tool and supplies adopted practice guideline initiative for follow up and therapy in CRC (El-Awady S,et al. Hepatogastroenterology 2009;56: ). The serum CEA has high specificity but insufficient sensitivity for detecting CRC recurrence (Tan E, et al. Surg Oncol. 2009;18:15-24) and approximate 30% of all CRC recurrences have normal CEA serum levels (Safi F, et al. Dis Colon Rectum 1993; 36: ). Since any single marker is not sufficiently predictive, combination of different markers representing different aspects of tumor biology will have a better prognostic evaluation (Zlobec I, et al.cancer 2008, 112: , Uen YH, et al. Ann Surg 2007, 246: ). In the present study we found SNCG overexpression correlates with poor outcome and is an independent prognostic indicator. As SNCG level was not associated with preoperative serum CEA level, we were interested in investigating whether a combination of SNCG and CEA could improve prognostic evaluation in CRC. 2. Materials and Methods: Overall survival should be calculated from the date of surgery to the date of recorded death. Data of patients with lost follow-up should be censored. Same applies for disease free survival.

4 According to the reviewer s comments, we have corrected Overall survival time was calculated from the date of surgery to the date of death due to any cause or last follow-up visit. Disease-free survival (DFS) time was calculated for patients from the date of surgery to the date of disease progression (local recurrence or distant metastasis) or last follow-up visit. to Overall survival time was calculated from the date of surgery to the date of death due to any cause. Disease-free survival (DFS) time was calculated for patients from the date of surgery to the date of disease progression (local recurrence or distant metastasis).. 3. In the results section, where the correlation between SNCG expression and survival is presented, the second half of the first paragraph A significant difference in survival rate was observed is redundant to the first half of this paragraph. Additionally, in the first half a p-value of < is presented for survival association, while in the second half a p-value of is presented. Which one is correct? Please clarify and remove repetitions. According to the reviewer s comments, we have deleted the repetitions A significant difference in survival rate was observed in 5-year follow up. While there were 58.0% for DFS and 58.7% for OS in patients without SNCG expression, SNCG-positive patients had a 32.9% DFS and 32.5% OS. from the paragraph. The P< in the first half represented the difference of mean time for survival between SNCG negative group and SNCG positive group (P<0.0001),while in the second half the P=0.001 showed the hazard ratio of death according to SNCG level was (95%CI, , P=0.001). 4. Results: The conclusion that SNCG is a stronger predictive factor than intravascular embolus or weaker then depth of tumor invasion cannot be drawn from the data presented. This conclusion could only be drawn if the 95% confidence intervals of the hazard ratios for both markers were not overlapping. According to the reviewer s comments, we have corrected Multivariate analysis revealed that the

5 influence of SNCG on DFS and OS (P=0.039, 0.048) of the 229 patients was significantly stronger than intravascular embolus (P=0.049, 0.050) but weaker than TNM stage (P=0.008, 0.006) and depth of tumor invasion (P=0.025, 0.028). Based on these analyses, we concluded that tumor SNCG level can be considered as an independent prognostic factor for DFS and OS of the patients with colon adenocarcinoma. to Multivariate analysis revealed that SNCG was an independent prognostic factor for DFS (P=0.039) and OS(P= 0.048) of the patients with colon adenocarcinoma. 5. The same applies for the comparison of hazard ratios. If the 95% confidence intervals overlap (which is the case for all data presented in the next paragraph regarding CEA/SNCG combo versus CEA and SNCG alone), no statement regarding which one of the investigated markers is better than the other can be made. Instead they are then assumed to be of NO significant difference in this study population. Therefore all the statements about the suggested superiority of the marker combination compared to the single marker analyses may be wrong. According to the reviewer s comments, we have corrected Very importantly, the hazard ratio of combined CEA and SNCG for DFS and OS were and 3.645, significantly higher than those of CEA (2.440 and 2.639), and SNCG (2.213 and 2.141), respectively. These data suggest that combination of CEA and SNCG indicates a worsen survival outcome than either SNCG or CEA alone. to Very importantly, the hazard ratio of combined CEA and SNCG for DFS and OS were and 3.645, and for CEA, and and for SNCG, respectively. These data suggested that the combination of CEA and SNCG was a strong prognostic indicator.. 6. The same mistake is unfortunately carried on in the next (last) paragraph of the results as well: You really cannot compare pure hazard ratios. For all the markers (SNCG, Tumor size, Tumor differentiation) the 95% confidence intervals are largely overlapping (Table 4). There is NO significant difference in the presented study population for these markers.

6 We have corrected The hazard ratio of recurrence according to combined SNCG with CEA was (95%CI, , P=0.001), higher than SNCG (2.958, 95% CI, , P = 0.002) and CEA (3.401, 95%CI, , P=0.001). Combination of CEA with SNCG improves prognostic evaluation for patients with colon adenocarcinoma. to The hazard ratio of recurrence according to combined SNCG with CEA was (95%CI, , P=0.001), for SNCG (95% CI, , P = 0.002) and for CEA (95%CI, , P=0.001). Combination of CEA with SNCG might improve prognostic evaluation for patients with colon adenocarcinoma.. 7. What is the rationale to look at the subgroup of CEA negative patients in specific? The sample size becomes pretty small and CEA is not a strong predictive marker for colon cancer anyway, rather than a serial follow-up marker. As the information gathered from this subgroup does not add any useful data to the observations among the whole study population, I would suggest to remove this sub-evaluation. Approximate 30% of all CRC recurrences is negative of CEA serum levels and few studies have investigated the surveillance of those sub-patients. Our results showed SNCG was overexpressed in 35% (34/97) of colon cancer tissues from patients with negative CEA level and SNCG level still was an independent prognostic factor for DFS and OS for colon cancer patients with negative serum CEA level. 8. Discussion: The discussion is mainly based on the assumed higher prognostic value of SNCG or the CEA/SNCG combo which is unfortunately statistically wrong as it cannot be assessed within the available data. It should therefore be rewritten accordingly. We have corrected We investigated the impact of SNCG level on the clinical outcome of patients with normal preoperative serum CEA levels. Our results demonstrated that SNCG remained an independent prognostic variable for these patients and affected patients survival more than TNM stage, lymph node metastasis, depth of invasion, tumor size and differentiation grade into We investigated the impact of SNCG level on the clinical outcome of patients with normal

7 preoperative serum CEA levels and our results demonstrated that SNCG remained an independent prognostic variable for these patients and affected patients survival, but the clinicopathologic factors such as TNM stage, lymph node metastasis, and depth of invasion,, all didn t influence the patients survival. The sentence We also demonstrated that combination of CEA and SNCG has a significant additive value and provides a higher prognostic value in colon cancer than each of them considered separately for patients with stages I-II and III-IV. Tumor SNCG and preoperative CEA can provide mutual complementary prognostic value and combined analyses of SNCG with CEA provide a better prognosis on survival outcome for patients compared with either marker was modified to We also demonstrated that combination of CEA and SNCG has a significant additive value and provides a high prognostic value in colon cancer. Tumor SNCG and preoperative CEA may provide mutual complementary prognostic value and combined analyses of SNCG with CEA provide a strong prognosis on survival outcome for patients with colon cancer. 9. Mat/Met: Was the analysis carried out on whole tissue sections, or were the cases arrayed in a tissue-micro-array? Please specify. The analysis carried out on whole tissue sections, which was specified in the Method section. 10. I don t understand the scoring system for synuclein expression. Specifically a total score for area adding grade of 3 remains unclear. Finally the authors only derive a positive and negative category for their statistical evaluation. What is the reason to use the complex scoring system? Please clarify. This is a classical immunohistochemical category method that is called four-value classification scale (Lee JC et al. Eur J Cancer.2000; 36: ).

8 We have changed A semiquantitative scoring system was performed according to the following scoring system:.. into Immunoreactivity for SNCG in tumour cells was graded as either negative or positive according to a four-value classification scale as follows: 11. Results: What exactly was the heterogeneous expression pattern of synuclein? Was there a predominance of staining e.g. at the tumor margins? Or was the staining randomly dispersed among the tumor cells? It is well known that the cells in cancer tissue are heterogeneous in terms of morphology and differentiation status, even if the cancer tissue consists of progeny developed from a single neoplastic cell. (Nowell, PC. Science 1976, 194:23-28). Heterogeneous expression between cells has only been fully realized with the staining of sections of tumors with monoclonal antibodies. ( Edwards PAW. Br J Cancer 1985; 51: ) 12. If 4 cases showed staining of normal mucosa, synuclein is not specifically expressed in tumors and is not limited to adenocarcinomas. Please rephrase. We changed SNCG specifically expressed in colon adenocarcinoma cells and SNCG level was associated with intravascular embolus into SNCG is overexpressed in colon adenocarcinoma cells and is associated with intravascular embolus and deleted the phrase These data indicate that expression of SNCG in colon epithelium is limited to colon adenocarcinomas. Reviewer 2: 1. The authors should specifically address the frequency, rate of DFS, and OS of SNCG negative patients that are CEA positive. This will give insight to the readers as to how useful SNCG expression is to improving current diagnostic methods (CEA positive versus negative) versus improving diagnostic tests for patients who have normal CEA levels.

9 Thanks for the suggestions. We have added There were 42% (45/108) of patients with elevated CEA levels in the SNCG negative group, rates of DFS and OS of these patients were 43% and 39% at 5 year after surgery in section 4 of results. 2. para. 1 of Background section - "Traditionally, TNM stage is the..." The word system should be removed from this sentence. According to the reviewer s suggestions, we have removed system from this sentence. 3. para. 1 of Background section "...but accurate classification of intermediate-stage cases is imprecise and prognosis varies greatly in CRC patients even in the same stage." It is unclear why the authors are making this point since this paragraph is motivating the This sentence want to tell readers why it is necessary for discovery new biomarkers for predicting prognosis of CRC patients. To make it is more clearly, we have changed but accurate classification of intermediate-stage cases is imprecise and prognosis varies greatly in CRC patients even in the same stage into but current classification of CRC cann t predict prognosis precisely even for the patients in the same clinical stage." 4. para. 1 of Background section - Correct the grammar. "Approximately 30% of all CRC recurrences..." We have corrected Approximately 30% of all CRC recurrences... into Approximate 30% of all CRC recurrences. 5. para. 3 of Background section - Correct the grammar. "However, the prognostic significance of SNCG in other cancers remains unknown.." We have corrected However, prognostic significance of SNCG in other cancers has remained unknown. to However, the prognostic significance of SNCG in other cancers remains

10 unknown. 6. para. 3 of Background section - The authors need to be more specific as to how SNCG can be used prognostically. In particular, the authors are comparing SNCG levels as assessed by immunohistochemistry of tumor sections with serum CEA levels for their prognostic value. The current manner in which these points are described may be confusing to the reader. For example, "In the current study, we investigated whether SNCG expression levels as assessed by immunohistochemical analysis of excised tumor sections could be a useful prognostic marker for colon cancer patients and particularly for those with normal preoperative serum CEA level." According to the reviewer s suggestions, we have changed However, prognostic significance of SNCG in other cancers has remained unknown. In the current study, we investigated whether SNCG level could be a useful prognostic marker for colon cancer patients and particularly for those with normal preoperative serum CEA level. We also evaluated whether combination of SNCG with CEA could improve prognostic value. into However, the prognostic significance of SNCG in other cancers remains unknown. In the current study, SNCG level as assessed by immunohistochemistry of tumor sections is an independent prognostic factor of a shorter DFS and OS for colon cancer patients. Importantly, SNCG remains a prognostic determinant of DFS and OS for colon cancer patients with normal preoperative serum CEA level.. 7. para. 3 of Background section - The last sentence of this paragraph needs to be clarified. According to the reviewer s suggestions, we have changed In the current study, we investigated whether SNCG level could be a useful prognostic marker for colon cancer patients and particularly for those with normal preoperative serum CEA level. We also evaluated whether combination of SNCG with CEA could improve prognostic value. into In the current study, SNCG level as assessed by immunohistochemistry of tumor sections is an independent prognostic factor of a shorter DFS and OS for colon cancer patients. Importantly, SNCG remains a prognostic determinant of DFS and OS for colon cancer patients with normal preoperative serum CEA

11 level.. 8. The authors should comment on what is considered positive versus negative CEA levels and how that compares with the cut off they used in their analysis. We have changed The serum levels of CEA were considered positive when they were equal to or higher than 5.0 ng/ml according to the manufacture s instructions. into The serum levels of CEA were considered positive when they were equal to or higher than 5.0 ng/ml (cutoff value) and negative when lower than that according to the manufacture s instructions.. 9. Section title 1 of Results section - grammar should be improved. We have corrected SNCG specifically expressed in colon adenocarcinoma cells and SNCG level was associated with intravascular embolus into SNCG is overexpressed in colon adenocarcinoma cells and is associated with intravascular embolus 10. para. 2, section 1, results - Correct the grammar. "Interestingly, in contrast to previous observations of an association between SNCG expression and tumor stage..." We have corrected Interestingly, in contrast to previous observation of association between SNCG expression and tumor stages in many different cancers [11,15], into Interestingly, in contrast to previous observations of an association between SNCG expression and tumor stage in many different cancers [11,15],. 11. para. 2, section 1, results - Correct the grammar. "Expression of SNCG in primary tumors (p=0.023) was..."

12 We have corrected Expression of SNCG in primary tumor (P=0.023) also into Expression of SNCG in primary tumors (P=0.023) was also. 12. para. 2, section 1, results - Correct the grammar. "There were 61 patients that developed tumor recurrence during the follow-up period." We have corrected There were 61 patients developed recurrence during the follow-up. into There were 61 patients developed tumor recurrence during the follow-up period para. 2, section 1, results - Correct the grammar. "While 37% patients with SNCG positive primary tumor developed recurrence, only 22% patients with SNCG negative tumors developed recurrence (P = 0.02)." We have corrected While 37% patients with SNCG positive primary tumor developed recurrence, only 22% patients with SNCG negative tumors developed recurrence (P = 0.02). into While 37% of patients with SNCG positive primary tumor developed tumor recurrence, only 22% of patients with SNCG negative tumors developed tumor recurrence (P = 0.02) Section title 2 of Results section - grammar should be improved. We have changed SNCG overexpression correlated with poor outcome and was an independent prognostic indicator into SNCG overexpression correlates with poor outcome and is an independent prognostic indicator. 15. Throughout, "in SNCG negative group" should be written as "in the SNCG negative group" and likewise for the SNCG positive group.

13 We have changed in SNCG negative/positive group into in the SNCG negative/positive group throughout the manuscript. 16. para. 1 section 3, results - Correct the grammar. "whether a combination of SNCG and CEA." We have corrected whether combination of SNCG and CEA into whether a combination of SNCG and CEA. 17. para. 1, section 3, results - The last sentence of this paragraph needs to be corrected to be grammatically correct. We have corrected These data suggest that combination of CEA and SNCG indicates a worsen survival outcome than either SNCG or CEA alone. into These data suggested that the combination of CEA and SNCG was a strong prognostic indicator para. 2, section 3, results - Correct the grammar. "Figure 2 illustrates..." We have corrected Figure 2 illustrated into Figure 2 illustrates. 19. para. 2, section 3, results - The grammar of this paragraph needs to be improved. We have corrected Combination of CEA with SNCG improves prognostic evaluation for patients with colon adenocarcinoma. Into Combination of CEA with SNCG might improve prognostic evaluation for patients with colon adenocarcinoma The grammar of the title of Table 2 needs to be corrected.

14 We have corrected SNCG Specifically Expressed on Colon Adenocarcinoma. SNCG level in total 460 clinical colon specimens was investigated by immunohistochemistry into SNCG Expressing Profile in Colon Adenocarcinoma. according to the reviewer s suggestions. Reviewer 3: 1. For the most part the introduction and discussion lack description of the potential biological function of synuclein gamma. More detailed introduction and discussion of the biological role of this protein should be provided. Thanks very much for the suggestions. We have added the potential biological function of synuclein gamma in the Introduction section. 2. The quality of Figure 1 panel A should be improved. Particularly the normal crypts are difficult to visualize as the image is too bright. We have improved the quality of Figure 1 panel A according to the reviewer s comments.

Author's response to reviews

Author's response to reviews Author's response to reviews Title: Brain metastasis development and poor survival associated with carcinoembryonic antigen (CEA) level in advanced non-small cell lung cancer: a prospective analysis Authors:

More information

Synuclein gamma predicts poor clinical outcome in colon cancer with normal levels of carcinoembryonic antigen

Synuclein gamma predicts poor clinical outcome in colon cancer with normal levels of carcinoembryonic antigen RESEARCH ARTICLE Open Access Research article Synuclein gamma predicts poor clinical outcome in colon cancer with normal levels of carcinoembryonic antigen Caiyun Liu 1,2, Bin Dong 3, Aiping Lu 3, Like

More information

Title: Survival endpoints in colorectal cancer. The effect of second primary other cancer on disease free survival.

Title: Survival endpoints in colorectal cancer. The effect of second primary other cancer on disease free survival. Author's response to reviews Title: Survival endpoints in colorectal cancer. The effect of second primary other cancer on disease free survival. Authors: Helgi Birgisson (helgi.birgisson@surgsci.uu.se)

More information

Title: Use of food labels by adolescents to make healthier choices on snacks: a cross sectional study from Sri Lanka

Title: Use of food labels by adolescents to make healthier choices on snacks: a cross sectional study from Sri Lanka Author s response to reviews Title: Use of food labels by adolescents to make healthier choices on snacks: a cross sectional study from Sri Lanka Authors: Ishanka Talagala (drmaheshkeerthi@gmail.com;drishanka@gmail.com)

More information

Title: Small cell carcinoma arising in Barrett's esophagus: a case report and review of the literature

Title: Small cell carcinoma arising in Barrett's esophagus: a case report and review of the literature Author's response to reviews Title: Small cell carcinoma arising in Barrett's esophagus: a case report and review of the literature Authors: Haridimos Markogiannakis (markogiannakis@easy.com) Dimitrios

More information

Title:Continuity of GP care is associated with lower use of complementary and alternative medical providers A population-based cross-sectional survey

Title:Continuity of GP care is associated with lower use of complementary and alternative medical providers A population-based cross-sectional survey Author's response to reviews Title:Continuity of GP care is associated with lower use of complementary and alternative medical providers A population-based cross-sectional survey Authors: Anne Helen Hansen

More information

Author's response to reviews

Author's response to reviews Author's response to reviews Title: Intensive post-operative follow-up of breast cancer patients with tumour markers: CEA, TPA or CA15.3 vs MCA and MCA-CA15.3 vs CEA-TPA-CA15.3 panel in the early detection

More information

RE: Title: Practical fecal calprotectin cut-off value for Japanese patients with ulcerative colitis

RE: Title: Practical fecal calprotectin cut-off value for Japanese patients with ulcerative colitis September 10, 2018 Professor Xue-Jiao Wang, MD Science Editor Editorial Office 'World Journal of Gastroenterology' RE: 40814 Title: Practical fecal calprotectin cut-off value for Japanese patients with

More information

Original Article CREPT expression correlates with esophageal squamous cell carcinoma histological grade and clinical outcome

Original Article CREPT expression correlates with esophageal squamous cell carcinoma histological grade and clinical outcome Int J Clin Exp Pathol 2017;10(2):2030-2035 www.ijcep.com /ISSN:1936-2625/IJCEP0009456 Original Article CREPT expression correlates with esophageal squamous cell carcinoma histological grade and clinical

More information

WHAT SHOULD WE DO WITH TUMOUR BUDDING IN EARLY COLORECTAL CANCER?

WHAT SHOULD WE DO WITH TUMOUR BUDDING IN EARLY COLORECTAL CANCER? CANCER STAGING TNM and prognosis in CRC WHAT SHOULD WE DO WITH TUMOUR BUDDING IN EARLY COLORECTAL CANCER? Alessandro Lugli, MD Institute of Pathology University of Bern Switzerland Maastricht, June 19

More information

Title: Socioeconomic conditions and number of pain sites in women

Title: Socioeconomic conditions and number of pain sites in women Author's response to reviews Title: Socioeconomic conditions and number of pain sites in women Authors: Finn E Skjeldestad (fisk@fhi.no) Toril Rannestad (Toril.Rannestad@hist.no) Version: 2 Date: 17 January

More information

Title:COX-2 overexpression in resected pancreatic head adenocarcinomas correlates with favourable prognosis

Title:COX-2 overexpression in resected pancreatic head adenocarcinomas correlates with favourable prognosis Author's response to reviews Title:COX-2 overexpression in resected pancreatic head adenocarcinomas correlates with favourable prognosis Authors: Ewa Pomianowska (ewa.pomianowska@medisin.uio.no) Aasa R

More information

Title: Peritumoral Vascular Invasion and NHERF1 expression define an immunophenotype of grade 2 invasive breast cancer associated with poor prognosis

Title: Peritumoral Vascular Invasion and NHERF1 expression define an immunophenotype of grade 2 invasive breast cancer associated with poor prognosis Author's response to reviews Title: Peritumoral Vascular Invasion and NHERF1 expression define an immunophenotype of grade 2 invasive breast cancer associated with poor prognosis Authors: Andrea Malfettone

More information

Title: TIMP-1 and VEGF-165 serum concentration during first-line therapy of ovarian cancer patients

Title: TIMP-1 and VEGF-165 serum concentration during first-line therapy of ovarian cancer patients Author's response to reviews Title: TIMP-1 and VEGF-165 serum concentration during first-line therapy of ovarian cancer patients Authors: Sven Mahner (Sven.Mahner@gmx.de) Linn Woelber (lwoelber@uke.uni-hamburg.de)

More information

High expression of fibroblast activation protein is an adverse prognosticator in gastric cancer.

High expression of fibroblast activation protein is an adverse prognosticator in gastric cancer. Biomedical Research 2017; 28 (18): 7779-7783 ISSN 0970-938X www.biomedres.info High expression of fibroblast activation protein is an adverse prognosticator in gastric cancer. Hu Song 1, Qi-yu Liu 2, Zhi-wei

More information

Cover Letter. Reviewer 1:

Cover Letter. Reviewer 1: Cover Letter Michael Yang, M.D., Ph.D. Managing Editor of Cancer Research Frontiers 1188 Willis Ave, #109, Albertson, NY 11507, USA Phone: +1-917-426-1571 http://cancer-research-frontiers.org/ Dear Dr.

More information

Title: Human breast cancer associated fibroblasts exhibit subtype specific gene expression profiles

Title: Human breast cancer associated fibroblasts exhibit subtype specific gene expression profiles Author's response to reviews Title: Human breast cancer associated fibroblasts exhibit subtype specific gene expression profiles Authors: Julia Tchou (julia.tchou@uphs.upenn.edu) Andrew V Kossenkov (akossenkov@wistar.org)

More information

Title: Intention-to-treat and transparency of related practices in randomized, controlled trials of anti-infectives

Title: Intention-to-treat and transparency of related practices in randomized, controlled trials of anti-infectives Author s response to reviews Title: Intention-to-treat and transparency of related practices in randomized, controlled trials of anti-infectives Authors: Robert Beckett (rdbeckett@manchester.edu) Kathryn

More information

Rare Small Cell Carcinoma in Genitourinary Tract: Experience from E-Da Hospital

Rare Small Cell Carcinoma in Genitourinary Tract: Experience from E-Da Hospital E-Da Medical Journal 20;():-5 Original Article Rare Small Cell Carcinoma in Genitourinary Tract: Experience from E-Da Hospital Wei-Ting Kuo, I-Wei Chang2, Kevin Lu, Hua-Pin Wang, Tsan-Jung u, Victor C.

More information

Lower lymph node yield following neoadjuvant therapy for rectal cancer has no clinical significance

Lower lymph node yield following neoadjuvant therapy for rectal cancer has no clinical significance Original Article Lower lymph node yield following neoadjuvant therapy for rectal cancer has no clinical significance Dedrick Kok Hong Chan 1,2, Ker-Kan Tan 1,2 1 Division of Colorectal Surgery, University

More information

Author s response to reviews

Author s response to reviews Author s response to reviews Title: Association between Charlson comorbidity index score and outcome in patients with stage IIIB-IV non-small cell lung cancer Authors: Lei Zhao (zhaoleilei0507@126.com)

More information

Title: Prediction of HIV-1 virus-host protein interactions using virus and host sequence motifs

Title: Prediction of HIV-1 virus-host protein interactions using virus and host sequence motifs Author's response to reviews Title: Prediction of HIV-1 virus-host protein interactions using virus and host sequence motifs Authors: Perry PE Evans (evansjp@mail.med.upenn.edu) Will WD Dampier (wnd22@drexel.edu)

More information

Title: The effect of Breast Cancer Awareness Month on Internet search activity - a comparison with awareness campaigns for lung and prostate cancer

Title: The effect of Breast Cancer Awareness Month on Internet search activity - a comparison with awareness campaigns for lung and prostate cancer Author's response to reviews Title: The effect of Breast Cancer Awareness Month on Internet search activity - a comparison with awareness campaigns for lung and prostate cancer Authors: Ronan W Glynn (ronanglynn@doctors.net.uk)

More information

Early colorectal cancer Quality and rules for a good pathology report Histoprognostic factors

Early colorectal cancer Quality and rules for a good pathology report Histoprognostic factors Early colorectal cancer Quality and rules for a good pathology report Histoprognostic factors Frédéric Bibeau, MD, PhD Pathology department Biopathology unit Institut du Cancer de Montpellier France Quality

More information

Title:Fulvic acid attenuates homocysteine-induced cyclooxygenase-2 expression in human monocytes

Title:Fulvic acid attenuates homocysteine-induced cyclooxygenase-2 expression in human monocytes Author's response to reviews Title:Fulvic acid attenuates homocysteine-induced cyclooxygenase-2 expression Authors: Shao-Ju Chien (csjdc@adm.cgmh.org.tw) Te-Chuan Chen (ma4671@gmail.com) Hsing-Chun Kuo

More information

An exploratory analysis of g-synuclein expression in endometrioid endometrial cancer

An exploratory analysis of g-synuclein expression in endometrioid endometrial cancer Open Access Research An exploratory analysis of g-synuclein expression in endometrioid endometrial cancer Jing Zou, Yujuan J Fan, Yaqing Q Meng, Hong Xu, Jiangtao Fan To cite: Zou J, Fan YJ, Meng YQ, et

More information

Surgical Management of Metastatic Colon Cancer: analysis of the Surveillance, Epidemiology and End Results (SEER) database

Surgical Management of Metastatic Colon Cancer: analysis of the Surveillance, Epidemiology and End Results (SEER) database Surgical Management of Metastatic Colon Cancer: analysis of the Surveillance, Epidemiology and End Results (SEER) database Hadi Khan, MD 1, Adam J. Olszewski, MD 2 and Ponnandai S. Somasundar, MD 1 1 Department

More information

Lymph node ratio as a prognostic factor in stage III colon cancer

Lymph node ratio as a prognostic factor in stage III colon cancer Lymph node ratio as a prognostic factor in stage III colon cancer Emad Sadaka, Alaa Maria and Mohamed El-Shebiney. Clinical Oncology department, Faculty of Medicine, Tanta University, Egypt alaamaria1@hotmail.com

More information

Title:Modern contraceptive use among sexually active men in Uganda: Does discussion with a health worker matter?

Title:Modern contraceptive use among sexually active men in Uganda: Does discussion with a health worker matter? Author's response to reviews Title:Modern contraceptive use among sexually active men in Uganda: Does discussion with a health worker matter? Authors: Allen Kabagenyi Ms. (allenka79@yahoo.com) Patricia

More information

Expression of mir-1294 is downregulated and predicts a poor prognosis in gastric cancer

Expression of mir-1294 is downregulated and predicts a poor prognosis in gastric cancer European Review for Medical and Pharmacological Sciences 2018; 22: 5525-5530 Expression of mir-1294 is downregulated and predicts a poor prognosis in gastric cancer Y.-X. SHI, B.-L. YE, B.-R. HU, X.-J.

More information

Colorectal Cancer and FDG PET/CT

Colorectal Cancer and FDG PET/CT Hybrid imaging in colorectal & esophageal cancer Emmanuel Deshayes IAEA WorkShop, November 2017 Colorectal Cancer and FDG PET/CT 1 Clinical background Cancer of the colon and rectum is one of the most

More information

Surgical Issues in Melanoma

Surgical Issues in Melanoma Surgical Issues in Melanoma Mark B. Faries, MD, FACS Director, Donald L. Morton Melanoma Research Program Director, Surgical Oncology Training Program Professor of Surgery John Wayne Cancer Institute Surgical

More information

Disclosures. Outline. What IS tumor budding?? Tumor Budding in Colorectal Carcinoma: What, Why, and How. I have nothing to disclose

Disclosures. Outline. What IS tumor budding?? Tumor Budding in Colorectal Carcinoma: What, Why, and How. I have nothing to disclose Tumor Budding in Colorectal Carcinoma: What, Why, and How Disclosures I have nothing to disclose Soo-Jin Cho, MD, PhD Assistant Professor UCSF Dept of Pathology Current Issues in Anatomic Pathology 2017

More information

Guideline. Associated Documents ASCO CAP 2018 GUIDELINES and SUPPLEMENTS -

Guideline. Associated Documents ASCO CAP 2018 GUIDELINES and SUPPLEMENTS - Guideline Subject: ASCO CAP 2018 HER2 Testing for Breast Cancer Guidelines - Recommendations for Practice in Australasia Approval Date: December 2018 Review Date: December 2022 Review By: HER2 testing

More information

Taiwan. Taiwan. 807, Taiwan. Taiwan

Taiwan. Taiwan. 807, Taiwan. Taiwan Annals of Surgical Oncology 15(8):2120 2128 DOI: 10.1245/s10434-008-9961-7 Persistent Presence of Postoperative Circulating Tumor Cells is a Poor Prognostic Factor for Patients with Stage I III Colorectal

More information

Although the international TNM classification system

Although the international TNM classification system Prognostic Significance of Perioperative Serum Carcinoembryonic Antigen in Non-Small Cell Lung Cancer: Analysis of 1,000 Consecutive Resections for Clinical Stage I Disease Morihito Okada, MD, PhD, Wataru

More information

Management of Vulvar Cancer: How to Handle Close Margins?

Management of Vulvar Cancer: How to Handle Close Margins? Management of Vulvar Cancer: How to Handle Close Margins? Sven Mahner, MD Department of Gynecology and Obstetrics University of Munich AGO Study Group Munich, Germany Surgical Resection of Vulvar Cancer

More information

Title: Evaluation of the Housing First Program in patients with severe mental disorders in France: study protocol for a randomised controlled trial

Title: Evaluation of the Housing First Program in patients with severe mental disorders in France: study protocol for a randomised controlled trial Author's response to reviews Title: Evaluation of the Housing First Program in patients with severe mental disorders in France: study protocol for a randomised controlled trial : Aurelie Tinland (laurent.boyer@ap-hm.fr)

More information

Scientific Editing Report

Scientific Editing Report Acknowledge editing support International publication guidelines such as ICMJE guidelines state that all non-author contributions, including editing, should be acknowledged. If you are satisfied with the

More information

Title:The role of BRCA1 and BRCA2 mutations in prostate, pancreatic and stomach cancers.

Title:The role of BRCA1 and BRCA2 mutations in prostate, pancreatic and stomach cancers. Author's response to reviews Title:The role of BRCA1 and BRCA2 mutations in prostate, pancreatic and stomach cancers. Authors: Helen Cavanagh (helen21987@hotmail.com) Katherine MA Rogers (k.rogers@qub.ac.uk)

More information

Preoperative CA 15-3 and CEA serum levels as predictor for breast cancer outcomes

Preoperative CA 15-3 and CEA serum levels as predictor for breast cancer outcomes Annals of Oncology 19: 675 681, 2008 doi:10.1093/annonc/mdm538 Published online 23 November 2007 Preoperative CA 15-3 and CEA serum levels as predictor for breast cancer outcomes B.-W. Park 1,4 *, J.-W.

More information

Chairman, Department of Sports Rehabilitation, Shanghai University of Sport

Chairman, Department of Sports Rehabilitation, Shanghai University of Sport Author s response to reviews Title: Effects of whole body vibration exercise on neuromuscular function for individuals with knee osteoarthritis: study protocol for a randomized controlled trial Authors:

More information

Title: Concurrence of villous adenoma and non-muscle invasive bladder cancer arising in the bladder: a case report

Title: Concurrence of villous adenoma and non-muscle invasive bladder cancer arising in the bladder: a case report Author's response to reviews Title: Concurrence of villous adenoma and non-muscle invasive bladder cancer arising in the bladder: a case report Authors: Yoichiro Kato (j2c789@bma.biglobe.ne.jp) Susumu

More information

2. Could you insert a reference, proving your statement on p. 5, l. 66/67?

2. Could you insert a reference, proving your statement on p. 5, l. 66/67? Author s response to reviews Title: Representative survey on idiopathic environmental intolerance attributed to electromagnetic fields in Taiwan and comparison with the international literature Authors:

More information

Author s response to reviews

Author s response to reviews Author s response to reviews Title: Robot-assisted radical prostatectomy significantly reduced biochemical recurrence compared to retro pubic radical prostatectomy Authors: Tetsuya Fujimura (tfujimura-jua@umin.ac.jp)

More information

Adjuvant/neoadjuvant systemic treatment of colorectal cancer

Adjuvant/neoadjuvant systemic treatment of colorectal cancer 5th ESO-ESMO Eastern Europe and Balkan Region Masterclass in Medical Oncology Belgrade, June 19 th 2018 Adjuvant/neoadjuvant systemic treatment of colorectal cancer Carlotta Antoniotti Polo Oncologico

More information

Title: Persistent tumor cells in bone marrow of early breast cancer patients after primary surgery are associated with inferior outcome

Title: Persistent tumor cells in bone marrow of early breast cancer patients after primary surgery are associated with inferior outcome Author's response to reviews Title: Persistent tumor cells in bone marrow of early breast cancer patients after primary surgery are associated with inferior outcome Authors: Kjersti Tjensvoll (ktje@sus.no)

More information

논문투고및투고후소통하기 : 영문교정작업, 실제논문투고하기, revision 답변달기, query form 작성하기

논문투고및투고후소통하기 : 영문교정작업, 실제논문투고하기, revision 답변달기, query form 작성하기 Apr 28, 2018 9:20-9:40 JGO Workshop 논문투고및투고후소통하기 : 영문교정작업, 실제논문투고하기, revision 답변달기, query form 작성하기 연세의대이정윤 좋은아이디어를얻기위하여, 타인으로부터유익한암시를받을때가있음. 새로운아이디어는두사람이상의지식및아이디어를함께모을때생겨나는경우가있음. 토론은잘못의발견에유익한방법임. 혼자독립하여동료와이야기를나누지않는연구자는틀린길을걸어가다많은시간을낭비하게되는경우가있음.

More information

Prosigna BREAST CANCER PROGNOSTIC GENE SIGNATURE ASSAY

Prosigna BREAST CANCER PROGNOSTIC GENE SIGNATURE ASSAY Prosigna BREAST CANCER PROGNOSTIC GENE SIGNATURE ASSAY Methodology The test is based on the reported 50-gene classifier algorithm originally named PAM50 and is performed on the ncounter Dx Analysis System

More information

Prosigna BREAST CANCER PROGNOSTIC GENE SIGNATURE ASSAY

Prosigna BREAST CANCER PROGNOSTIC GENE SIGNATURE ASSAY Prosigna BREAST CANCER PROGNOSTIC GENE SIGNATURE ASSAY GENE EXPRESSION PROFILING WITH PROSIGNA What is Prosigna? Prosigna Breast Cancer Prognostic Gene Signature Assay is an FDA-approved assay which provides

More information

Dear Mrs. Burch and editors of the BMJ,

Dear Mrs. Burch and editors of the BMJ, Dear Mrs. Burch and editors of the BMJ, We are pleased that our manuscript entitled: Sacrospinous hysteropexy versus vaginal hysterectomy with uterosacral ligament suspension in women with uterine prolapse

More information

Surveillance following treatment of primary ocular melanoma

Surveillance following treatment of primary ocular melanoma Surveillance following treatment of primary ocular melanoma Introduction 50% of UM patients relapse with predominantly liver metastases Risk of metastatic disease can be predicted relatively accurately

More information

National Surgical Adjuvant Breast and Bowel Project (NSABP) Foundation Annual Progress Report: 2009 Formula Grant

National Surgical Adjuvant Breast and Bowel Project (NSABP) Foundation Annual Progress Report: 2009 Formula Grant National Surgical Adjuvant Breast and Bowel Project (NSABP) Foundation Annual Progress Report: 2009 Formula Grant Reporting Period July 1, 2012 June 30, 2013 Formula Grant Overview The National Surgical

More information

Carcinoembryonic Antigen

Carcinoembryonic Antigen Other Names/Abbreviations CEA 190.26 - Carcinoembryonic Antigen Carcinoembryonic antigen (CEA) is a protein polysaccharide found in some carcinomas. It is effective as a biochemical marker for monitoring

More information

What Pathology can tell us in the approach of localized colorectal cancer

What Pathology can tell us in the approach of localized colorectal cancer What Pathology can tell us in the approach of localized colorectal cancer A/Prof Tony Lim Kiat Hon Department of Anatomical Pathology Singapore General Hospital ESMO 2017 Singapore Nov 1 2 Do we still

More information

Title: Identifying work ability promoting factors for home care aides and assistant nurses

Title: Identifying work ability promoting factors for home care aides and assistant nurses Author's response to reviews Title: Identifying work ability promoting factors for home care aides and assistant nurses Authors: Agneta Larsson (agneta.larsson@ltu.se) Lena Karlqvist (lena.karlqvist@ltu.se)

More information

The Depth of Tumor Invasion is Superior to 8 th AJCC/UICC Staging System to Predict Patients Outcome in Radical Cystectomy.

The Depth of Tumor Invasion is Superior to 8 th AJCC/UICC Staging System to Predict Patients Outcome in Radical Cystectomy. 30 th Congress of the European Society of Pathology Tuesday, September 11, 2018 The Depth of Tumor Invasion is Superior to 8 th AJCC/UICC Staging System to Predict Patients Outcome in Radical Cystectomy.

More information

Update on 2015 WHO Classification of Lung Adenocarcinoma 1/3/ Mayo Foundation for Medical Education and Research. All rights reserved.

Update on 2015 WHO Classification of Lung Adenocarcinoma 1/3/ Mayo Foundation for Medical Education and Research. All rights reserved. 1 Our speaker for this program is Dr. Anja Roden, an associate professor of Laboratory Medicine and Pathology at Mayo Clinic as well as consultant in the Anatomic Pathology Laboratory and co-director of

More information

Combined use of AFP, CEA, CA125 and CAl9-9 improves the sensitivity for the diagnosis of gastric cancer

Combined use of AFP, CEA, CA125 and CAl9-9 improves the sensitivity for the diagnosis of gastric cancer He et al. BMC Gastroenterology 2013, 13:87 RESEARCH ARTICLE Open Access Combined use of AFP, CEA, CA125 and CAl9-9 improves the sensitivity for the diagnosis of gastric cancer Chao-Zhu He 1,2, Kun-He Zhang

More information

Title:Number of tumor foci predicts prognosis in papillary thyroid cancer

Title:Number of tumor foci predicts prognosis in papillary thyroid cancer Author's response to reviews Title:Number of tumor foci predicts prognosis in papillary thyroid cancer Authors: Qing-hai Ji (quningfudan@hotmail.com) Ning Qu (jonathan_qn@163.com) Ling Zhang (zhangling@163.com)

More information

A nonresponding small cell lung cancer combined with adenocarcinoma

A nonresponding small cell lung cancer combined with adenocarcinoma Case Report A nonresponding small cell lung cancer combined with adenocarcinoma Hongyang Lu 1,2, Shifeng Yang 3 1 Zhejiang Key Laboratory of Diagnosis & Treatment Technology on Thoracic Oncology (Lung

More information

Title:Inhibitory effects of astaxanthin on azoxymethane-induced colonic preneoplastic lesions in C57/BL/KsJ-db/db mice

Title:Inhibitory effects of astaxanthin on azoxymethane-induced colonic preneoplastic lesions in C57/BL/KsJ-db/db mice Author's response to reviews Title:Inhibitory effects of astaxanthin on azoxymethane-induced colonic preneoplastic lesions in C57/BL/KsJ-db/db mice Authors: Takahiro Kochi (kottii924@yahoo.co.jp) Masahito

More information

The Impact of Adjuvant Chemotherapy in Pulmonary Large Cell Neuroendocrine Carcinoma (LCNC)

The Impact of Adjuvant Chemotherapy in Pulmonary Large Cell Neuroendocrine Carcinoma (LCNC) The Impact of Adjuvant Chemotherapy in Pulmonary Large Cell Neuroendocrine Carcinoma (LCNC) Disclosure None Background Torino, Italy LCNC Rare tumor (2% to 3% all resected primary lung cancers) Preoperative

More information

THE RELEVANCE OF SOME TUMORAL MARKERS IN PATIENTS WITH PANCREATIC CANCER

THE RELEVANCE OF SOME TUMORAL MARKERS IN PATIENTS WITH PANCREATIC CANCER THE RELEVANCE OF SOME TUMORAL MARKERS IN PATIENTS WITH PANCREATIC CANCER DANIEL TIMOFTE 1, RADU DANILA 1*, ALIN CIOBICA 2, CORNELIU DIACONU 1, ROXANA LIVADARIU 3, LIDIA IONESCU 1 Keywords: pancreatic cancer,

More information

Title: Value of fecal calprotectin in the evaluation of patients with abdominal discomfort: an observational study

Title: Value of fecal calprotectin in the evaluation of patients with abdominal discomfort: an observational study Author's response to reviews Title: Value of fecal calprotectin in the evaluation of patients with abdominal discomfort: an observational study Authors: Michael Manz (michael.manz@claraspital.ch) Emanuel

More information

Only Estrogen receptor positive is not enough to predict the prognosis of breast cancer

Only Estrogen receptor positive is not enough to predict the prognosis of breast cancer Young Investigator Award, Global Breast Cancer Conference 2018 Only Estrogen receptor positive is not enough to predict the prognosis of breast cancer ㅑ Running head: Revisiting estrogen positive tumors

More information

Title: Risser Patient Satisfaction Scale: A Validation study in Greek Cancer Patients

Title: Risser Patient Satisfaction Scale: A Validation study in Greek Cancer Patients Author's response to reviews Title: Risser Patient Satisfaction Scale: A Validation study in Greek Cancer Patients Authors: Andreas I Charalambous (andreas.charalambous@cut.ac.cy) Theodoula Adamakidou

More information

Department of Forest Ecosystems and Society, Oregon State University

Department of Forest Ecosystems and Society, Oregon State University July 4, 2018 Prof. Christopher Still Department of Forest Ecosystems and Society, Oregon State University 321 Richardson Hall, Corvallis OR 97331-5752 Dear Prof. Christopher Still, We would like to thank

More information

Prognostic significance of nemo like kinase in nasopharyngeal carcinoma

Prognostic significance of nemo like kinase in nasopharyngeal carcinoma MOLECULAR MEDICINE REPORTS 10: 131-136, 2014 Prognostic significance of nemo like kinase in nasopharyngeal carcinoma SIZE CHEN 1,2*, ZHIJIAN MA 3*, XUEMEI CHEN 4 and JIREN ZHANG 1 1 Department of Oncology,

More information

Immunohistochemical determinations in evaluating the prognostic in patient with urinary bladder tumors

Immunohistochemical determinations in evaluating the prognostic in patient with urinary bladder tumors Romanian Journal of Morphology and Embryology 2006, 47(2):175 179 ORIGINAL PAPER Immunohistochemical determinations in evaluating the prognostic in patient with urinary bladder tumors E. TRAŞCĂ 1), R.

More information

Title: Peripheral pulmonary nodules: relationship between multi-slice spiral CT perfusion imaging and tumor angiogenesis and VEGF expression

Title: Peripheral pulmonary nodules: relationship between multi-slice spiral CT perfusion imaging and tumor angiogenesis and VEGF expression Author's response to reviews Title: Peripheral pulmonary nodules: relationship between multi-slice spiral CT perfusion imaging and tumor angiogenesis and VEGF expression Authors: Shu-Hua Ma (mashuhua6699@sina.com)

More information

Original Article Tissue expression level of lncrna UCA1 is a prognostic biomarker for colorectal cancer

Original Article Tissue expression level of lncrna UCA1 is a prognostic biomarker for colorectal cancer Int J Clin Exp Pathol 2016;9(4):4241-4246 www.ijcep.com /ISSN:1936-2625/IJCEP0012296 Original Article Tissue expression level of lncrna UCA1 is a prognostic biomarker for colorectal cancer Hong Jiang,

More information

Title: Effect of heptavalent pneumococcal conjugate vaccination on invasive pneumococcal disease in preterm born infants

Title: Effect of heptavalent pneumococcal conjugate vaccination on invasive pneumococcal disease in preterm born infants Author's response to reviews Title: Effect of heptavalent pneumococcal conjugate vaccination on invasive pneumococcal disease in preterm born infants Authors: Simon Rueckinger (simon.rueckinger@med.uni-muenchen.de)

More information

Title: Elevated depressive symptoms in metabolic syndrome in a general population of Japanese men: a cross-sectional study

Title: Elevated depressive symptoms in metabolic syndrome in a general population of Japanese men: a cross-sectional study Author's response to reviews Title: Elevated depressive symptoms in metabolic syndrome in a general population of Japanese men: a cross-sectional study Authors: Atsuko Sekita (atsekita@med.kyushu-u.ac.jp)

More information

RESEARCH COMMUNICATION

RESEARCH COMMUNICATION DOI:http://dx.doi.org/10.7314/APJCP.2012.13.1.199 RESEARCH COMMUNICATION Prognostic Significance of CYFRA21-1, CEA and Hemoglobin in Patients with Esophageal Squamous Cancer Undergoing Concurrent Chemoradiotherapy

More information

Title: Effects of short-term heart rate variability biofeedback on long-term abstinence in alcohol dependent patients - a one-year follow up

Title: Effects of short-term heart rate variability biofeedback on long-term abstinence in alcohol dependent patients - a one-year follow up Author s response to reviews Title: Effects of short-term heart rate variability biofeedback on long-term abstinence in alcohol dependent patients - a one-year follow up Authors: Ana Isabel Penzlin (ana.penzlin@ppcr.org)

More information

Supplementary Information

Supplementary Information Supplementary Information Prognostic Impact of Signet Ring Cell Type in Node Negative Gastric Cancer Pengfei Kong1,4,Ruiyan Wu1,Chenlu Yang1,3,Jianjun Liu1,2,Shangxiang Chen1,2, Xuechao Liu1,2, Minting

More information

Clinicopathological Factors Affecting Distant Metastasis Following Loco-Regional Recurrence of breast cancer. Cheol Min Kang 2018/04/05

Clinicopathological Factors Affecting Distant Metastasis Following Loco-Regional Recurrence of breast cancer. Cheol Min Kang 2018/04/05 Abstract No.: ABS-0075 Clinicopathological Factors Affecting Distant Metastasis Following Loco-Regional Recurrence of breast cancer 2018/04/05 Cheol Min Kang Department of surgery, University of Ulsan

More information

The projection of short- and long-term survival for. Conditional Survival Among Patients With Carcinoma of the Lung*

The projection of short- and long-term survival for. Conditional Survival Among Patients With Carcinoma of the Lung* Conditional Survival Among Patients With Carcinoma of the Lung* Ray M. Merrill, PhD, MPH; Donald Earl Henson, MD; and Michael Barnes, PhD Objective: One- and 5-year probabilities of survival or death change

More information

Author's response to reviews

Author's response to reviews Author's response to reviews Title: A multicentre, double-blind, randomised, controlled, parallel-group study of the effectiveness of a pharmacist-acquired medication history in an emergency department

More information

Title:DNA Methylation Subgroups and the CpG Island Methylator Phenotype in Gastric Cancer: A Comprehensive Profiling Approach

Title:DNA Methylation Subgroups and the CpG Island Methylator Phenotype in Gastric Cancer: A Comprehensive Profiling Approach Author's response to reviews Title:DNA Methylation Subgroups and the CpG Island Methylator Phenotype in Gastric Cancer: A Comprehensive Profiling Approach Authors: Marie Loh (m.loh@imperial.ac.uk) Natalia

More information

Extent of visceral pleural invasion and the prognosis of surgically resected node-negative non-small cell lung cancer

Extent of visceral pleural invasion and the prognosis of surgically resected node-negative non-small cell lung cancer Thoracic Cancer ISSN 1759-7706 ORIGINAL ARTICLE Extent of visceral pleural invasion and the prognosis of surgically resected node-negative non-small cell lung cancer Yangki Seok 1, Ji Yun Jeong 2 & Eungbae

More information

Peritoneal Involvement in Stage II Colon Cancer

Peritoneal Involvement in Stage II Colon Cancer Anatomic Pathology / PERITONEAL INVOLVEMENT IN STAGE II COLON CANCER Peritoneal Involvement in Stage II Colon Cancer A.M. Lennon, MB, MRCPI, H.E. Mulcahy, MD, MRCPI, J.M.P. Hyland, MCh, FRCS, FRCSI, C.

More information

UNIVERSITY OF CALIFORNIA, LOS ANGELES

UNIVERSITY OF CALIFORNIA, LOS ANGELES UNIVERSITY OF CALIFORNIA, LOS ANGELES BERKELEY DAVIS IRVINE LOS ANGELES MERCED RIVERSIDE SAN DIEGO SAN FRANCISCO UCLA SANTA BARBARA SANTA CRUZ DEPARTMENT OF EPIDEMIOLOGY SCHOOL OF PUBLIC HEALTH CAMPUS

More information

A PRACTICAL APPROACH TO ATYPICAL MELANOCYTIC LESIONS BIJAN HAGHIGHI M.D, DIRECTOR OF DERMATOPATHOLOGY, ST. JOSEPH HOSPITAL

A PRACTICAL APPROACH TO ATYPICAL MELANOCYTIC LESIONS BIJAN HAGHIGHI M.D, DIRECTOR OF DERMATOPATHOLOGY, ST. JOSEPH HOSPITAL A PRACTICAL APPROACH TO ATYPICAL MELANOCYTIC LESIONS BIJAN HAGHIGHI M.D, DIRECTOR OF DERMATOPATHOLOGY, ST. JOSEPH HOSPITAL OBJECTIVES Discuss current trends and changing concepts in our understanding of

More information

Xiang Hu*, Liang Cao*, Yi Yu. Introduction

Xiang Hu*, Liang Cao*, Yi Yu. Introduction Original Article Prognostic prediction in gastric cancer patients without serosal invasion: comparative study between UICC 7 th edition and JCGS 13 th edition N-classification systems Xiang Hu*, Liang

More information

Title: Quality of life in childhood epilepsy with lateralized focus

Title: Quality of life in childhood epilepsy with lateralized focus Author's response to reviews Title: Quality of life in childhood epilepsy with lateralized focus Authors: Krystyna A. Mathiak (krystyna.mathiak@psych.uw.edu.pl) Malgorzata Luba (malgosia.luba@gmail.com)

More information

Number of lymph nodes identified in resected specimens of colorectal cancer from a variety of South African Hospitals: a retrospective study

Number of lymph nodes identified in resected specimens of colorectal cancer from a variety of South African Hospitals: a retrospective study Number of lymph nodes identified in resected specimens of colorectal cancer from a variety of South African Hospitals: a retrospective study Philippus Theunis du Plooy A research report submitted to the

More information

Molecular Testing Updates. Karen Rasmussen, PhD, FACMG Clinical Molecular Genetics Spectrum Medical Group, Pathology Division Portland, Maine

Molecular Testing Updates. Karen Rasmussen, PhD, FACMG Clinical Molecular Genetics Spectrum Medical Group, Pathology Division Portland, Maine Molecular Testing Updates Karen Rasmussen, PhD, FACMG Clinical Molecular Genetics Spectrum Medical Group, Pathology Division Portland, Maine Keeping Up with Predictive Molecular Testing in Oncology: Technical

More information

Multigene Testing in NCCN Breast Cancer Treatment Guidelines, v1.2011

Multigene Testing in NCCN Breast Cancer Treatment Guidelines, v1.2011 Multigene Testing in NCCN Breast Cancer Treatment Guidelines, v1.2011 Robert W. Carlson, M.D. Professor of Medicine Stanford University Chair, NCCN Breast Cancer Treatment Guidelines Panel Selection of

More information

Author's response to reviews

Author's response to reviews Author's response to reviews Title: Contribution of Interferon Gamma Release Assays testing to the Diagnosis of Latent Tuberculosis Infection in HIV-Infected Patients: A comparison of QuantiFERON Gold

More information

Title:Emergency ambulance service involvement with residential care homes in the support of older people with dementia: an observational study

Title:Emergency ambulance service involvement with residential care homes in the support of older people with dementia: an observational study Author's response to reviews Title:Emergency ambulance service involvement with residential care homes in the support of older people with dementia: an observational study Authors: Sarah Amador (s.amador@herts.ac.uk)

More information

Controversies in Breast Pathology ELENA PROVENZANO ADDENBROOKES HOSPITAL, CAMBRIDGE

Controversies in Breast Pathology ELENA PROVENZANO ADDENBROOKES HOSPITAL, CAMBRIDGE Controversies in Breast Pathology ELENA PROVENZANO ADDENBROOKES HOSPITAL, CAMBRIDGE Neoadjuvant Chemotherapy Indications: Management of locally advanced invasive breast cancers including inflammatory breast

More information

Title: A Prospective Study of Dietary Selenium Intake and Risk of Type 2 Diabetes

Title: A Prospective Study of Dietary Selenium Intake and Risk of Type 2 Diabetes Author's response to reviews Title: A Prospective Study of Dietary Selenium Intake and Risk of Type 2 Diabetes Authors: Saverio Stranges (S.Stranges@warwick.ac.uk) Sabina Sieri (Sabina.Sieri@istitutotumori.mi.it)

More information

Title:BRAF V600E mutation and KRAS codon 13 mutations predict poor survival in Chinese colorectal cancer patients

Title:BRAF V600E mutation and KRAS codon 13 mutations predict poor survival in Chinese colorectal cancer patients Author's response to reviews Title:BRAF V600E mutation and KRAS codon 13 mutations predict poor survival in Chinese colorectal cancer patients Authors: Jing Chen (jingchen871227@126.com) Fang Guo (wukongxiaofang@126.com)

More information

High risk stage II colon cancer

High risk stage II colon cancer High risk stage II colon cancer Joel Gingerich, MD, FRCPC Assistant Professor Medical Oncologist University of Manitoba CancerCare Manitoba Disclaimer No conflict of interests 16 October 2010 Overview

More information

CANCER REPORTING IN CALIFORNIA: ABSTRACTING AND CODING PROCEDURES California Cancer Reporting System Standards, Volume I

CANCER REPORTING IN CALIFORNIA: ABSTRACTING AND CODING PROCEDURES California Cancer Reporting System Standards, Volume I CANCER REPORTING IN CALIFORNIA: ABSTRACTING AND CODING PROCEDURES California Cancer Reporting System Standards, Volume I Changes and Clarifications 16 th Edition April 15, 2016 Quick Look- Updates to Volume

More information

DON M. PALLAIS, CPA 14 Dahlgren Road Richmond, Virginia Telephone: (804) Fax: (804)

DON M. PALLAIS, CPA 14 Dahlgren Road Richmond, Virginia Telephone: (804) Fax: (804) DON M. PALLAIS, CPA 14 Dahlgren Road Richmond, Virginia 23233 Telephone: (804) 784-0884 Fax: (804) 784-0885 Office of the Secretary PCAOB 1666 K Street, NW Washington, DC 20006-2083 Gentlemen: November

More information

Title: Treatment adherence among sputum smear-positive pulmonary tuberculosis patients in mountainous areas in China

Title: Treatment adherence among sputum smear-positive pulmonary tuberculosis patients in mountainous areas in China Author's response to reviews Title: Treatment adherence among sputum smear-positive pulmonary tuberculosis patients in mountainous areas in China Authors: Song Yao (ys506506@yahoo.com.cn) Wen-Hui Huang

More information

The prognostic value of p53 positive in colorectal cancer: A retrospective cohort study

The prognostic value of p53 positive in colorectal cancer: A retrospective cohort study 703651TUB0010.1177/1010428317703651Tumor BiologyWang et al. research-article2017 Original Article The prognostic value of p53 positive in colorectal cancer: A retrospective cohort study Tumor Biology May

More information