SUPPLEMENTARY INFORMATION

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1 SUPPLEMENTARY NFORMATON n format provided by Melero et al. (AUGUST 2015) Supplementary nformation S3 Combinations including two or more immunotherapy agents based on PD-1/PD-L1 blockade. (Source: accessed on May 2, 2015). ClinicalTrials. Treatment Phase Patient population N Status gov dentifier NVOLUMAB gemcitabine /cisplatin, pemetrexed /cisplatin, carboplatin /paclitaxel, bevacizumab maintenance, erlotinib or Nivolumab + sunitinib or pazopanib or bevacizumab or vs sunitinib Advanced NSCLC 412 Ongoing NCT Advanced untreated renal cell carcinoma Advanced renal cell carcinoma Previously untreated, advanced or metastatic renal cell carcinoma 175 NCT Ongoing NCT Ongoing NCT Advanced melanoma 160 Ongoing NCT Vaccine (Class Peptides) + Montanide SA 51VG + Resected stage C/ V nivolumab or 85 Ongoing NCT nivolumab Vaccine (Class Peptides) + Montanide SA 51VG + nivolumab Sequential nivolumab and followed by nivolumab pilimumab +/- nivolumab followed by dabrafenib/ trametinib or opposite sequence pilimumab vs. nivolumab vs. nivolumab + Unresectable Stage or V Malignant Unresectable Stage /V Metastatic to the Brain Previously Untreated, Unresectable or Metastatic Advanced BRAF V600 mutation-positive melanoma Previously Untreated Unresectable or Metastatic NCT NCT NCT Ongoing NCT NCT NCT NCT NATURE REVEWS CANCER

2 SUPPLEMENTARY NFORMATON n format provided by Melero et al. (AUGUST 2015) Dabrafenib + trametinib followed by + nivolumab at progression vs. +nivolumab followed by dabrafenib + trametinib at progression or lirilumab (anti-kr antibody) Nivolumab + Urelumab Nivolumab + pilimumab Nivolumab + HPV-16 Vaccination GVAX pancreas vaccine, cyclophosphamide + CRS /- nivolumab Nivolumab vs nivolumab + vs bevacizumab in solid tumours Nivolumab + varlilumab (anti CD27 antibody) Nivolumab + anti-lag-3 monoclonal antibody Expande d access - Advanced BRAFV600 Mutant Untreated, Unresectable or Metastatic Younger Patients With Recurrent or Refractory Solid Tumours or Sarcomas Lymphoma and Multiple Myeloma Advanced/Metastatic Solid Tumours and B-cell Non- Hodgkin Lymphoma Patients With Advanced HV Associated Solid Tumours Patients With HPV-16- Positive ncurable Solid Tumours Recurrent and Metastatic Microsatellite High Colon Cancer Previously Treated Metastatic Pancreatic Adenocarcinoma 300 Ongoing NCT Ongoing NCT Ongoing NCT Ongoing NCT Ongoing NCT NCT NCT Ongoing NCT Ongoing NCT Glioblastoma 440 Ongoing NCT Triple-negative breast cancer, gastric cancer, pancreatic adenocarcinoma, small cell lung cancer and bladder cancer Non-Small Cell Lung Cancer,, Colorectal, Ovarian or Head and Neck Squamous Cell Carcinoma. 410 Ongoing NCT Ongoing NCT Advanced Solid Tumours 168 Ongoing NCT NATURE REVEWS CANCER

3 SUPPLEMENTARY NFORMATON n format provided by Melero et al. (AUGUST 2015) Nivolumab + lirilumab (anti-kr antibody) Nivolumab + nterleukin-21 Nivolumab + NCB24360 (DO inhibitor) PEMBROLZUMAB carboplatin /paclitaxel, pemetrexed /carboplatin, bevacizumab maintenance, erlotinib, gefitinib or BCG Pembrolizumab and High Dose FN-alfa2b Pembrolizumab +Talimogene Laherparepvec Pf (4-1BB Agonist) NCB (DO inhibitor) Pegylated nterferon Alfa- 2b or pilimumab ADXS (viral vector + PSA) +/- Pembrolizumab Peginterferon Alfa-2b AM0010 (Pegylated L-10) + Pembrolizumab / chemotherapy / pazopanib ic9-gd2 (CAR) T Cell Lymphocytes + Cyclophosphamide + Fludarabine + pembrolizumab PDLZUMAB Pidilizumab + Dendritic Cell renal cell carcinoma vaccine Advanced Solid Tumours 162 Ongoing NCT Solid Tumours 33 Completed NCT Select Advanced Cancers 221 Ongoing NCT Advanced NSCLC 308 Ongoing NCT High Risk Superficial Bladder Cancer Locally/Regionally advanced/recurrent (neoadjuvant) Untreated, Unresected, Stage B to VM1c NCT NCT Ongoing NCT Advanced Solid Tumours 45 Ongoing NCT Selected Solid Tumours 120 Ongoing NCT Advanced (MEL) and Renal Cell Carcinoma Metastatic castrationresistant prostate cancer 343 Ongoing NCT Ongoing NCT Advanced 32 Ongoing NCT Advanced solid tumours 135 Ongoing NCT Relapsed or refractory neuroblastoma Renal Cell Carcinoma Ongoing NCT NCT Sipuleucel +/- pidilizumab Rand. Castration-resistant 57 Ongoing NCT NATURE REVEWS CANCER

4 SUPPLEMENTARY NFORMATON n format provided by Melero et al. (AUGUST 2015) +/- cyclophosphamide metastatic prostate cancer Multiple myeloma, Pidilizumab + Dendritic following Stem Cell Cell myeloma Vaccine Transplantation MPDL3280A NCB (DO inhibitor) RO (CD40 agonist) MPDL3280A +MOXR0916 (OX40 agonist) or interferonalpha RO (engineered L-2v + antibody against carcinoembryonic antigen) MED4736 MED Gefitinib or AZD9291 or selumetinib + docetaxel or followed by sequential MED4736 Tremelimumab +/- MED4736 ADXS or MED4736 or ADXS MED4736 MED4736 vs vs + MED MED4736 vs MED vs standard of care MED4736 +/- MED Motolimod (TLR-8 agonist) + Pegylated Liposomal Previously Treated Stage B or V Non-Small Cell Lung Cancer Metastatic or locally advanced solid tumours Locally advanced and/or Locally advanced or Locally advanced and/or 35 NCT Ongoing NCT Ongoing NCT NCT Ongoing NCT NCT Non-small cell lung cancer 301 Ongoing NCT Locally advanced or metastatic NSCLC Previously Treated Locally Cervical or HPV+ Head & Neck Cancer Recurrent or Metastatic Recurrent or Metastatic Recurrent gastric or gastroesophageal junction adenocarcinoma Recurrent, Platinum- Resistant Ovarian Cancer 40 Ongoing NCT Ongoing NCT Ongoing NCT NCT NCT Ongoing NCT NCT NATURE REVEWS CANCER

5 SUPPLEMENTARY NFORMATON n format provided by Melero et al. (AUGUST 2015) Doxorubicin Mogamulizumab (anti- CCR4) +MED4736 or MED4736 +AMP-514 (anti-pd-1) MED MED NCB (DO inhibitor) MED Tremelimumab +/- MED4736 Advanced solid tumours 108 Ongoing NCT Advanced Malignancies 160 Ongoing NCT Solid tumours 102 Ongoing NCT Selected advanced solid tumours 157 Ongoing NCT Advanced solid tumours 210 Ongoing NCT Japanese with advanced solid malignancies 22 Ongoing NCT Abbreviations: CAR: chimeric antigen receptor. CCR4; chemokine receptor 4. DO: indoleamine dioxygenase-1. TLR: toll-like receptor. NATURE REVEWS CANCER

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