Immunotherapy in Hematological Malignancies 2018

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1 1st Cuneo City Immunotherapy Conference (CCITC) Immunotherapy in Hematological Malignancies 2018 CUNEO May 17-19, 2018 Centro Incontri Organized by Prof. Massimo Massaia, SC Ematologia AO S. Croce e Carle, Cuneo, Italy and Centro Interdipartimentale di Ricerca in Biologia Molecolare (CIRBM), Torino, Italy PROGRAM

2 Thursday, May 17, Registration Welcome and information (Massimo Massaia - Cuneo - Torino) SESSION I: PASSIVE IMMUNOTHERAPY: TARGETING TUMOR CELLS (Mariella Grasso - Cuneo, Fabrizio Pane - Napoli) CD20 in lymphoma and chronic lymphocytic leukemia: groundwork and outlook (Umberto Vitolo - Torino) CD38 in myeloma and beyond: groundwork & outlook (Mario Boccadoro - Torino) CD123 in leukemia and beyond: groundwork & outlook (Giovanni Martinelli - Meldola - FC) In search of new markers in chronic lymphocytic leukemia and lymphoma (Gianluca Gaidano - Novara) Key Points (Fabrizio Pane - Napoli) Coffee break SESSION II: PASSIVE IMMUNOTHERAPY: ANTIBODY-DRUG CONJUGATES (Davide Rapezzi - Cuneo, Armando Santoro - Rozzano - MI) CD22: Inotuzumab ozogamicin (Sabina Chiaretti - Roma) CD30: Brentuximab vedotin (Antonello Pinto - Napoli) CD33: Gemtuzumab ozogamicin (Filippo Gherlinzoni - Treviso) CD79a: Polatuzumab vedotin (Maurizio Martelli - Roma) Key Points (Armando Santoro - Rozzano - MI) LECTURE: Emerging targets in acute myeloid leukemia (Sergio Amadori - Roma)

3 Friday, May 18, 2018 SESSION III: PASSIVE IMMUNOTHERAPY: TARGETING THE TUMOR MICROENVIRONMENT (Margherita Bonferroni - Cuneo, Mario Luppi - Modena) LECTURE: Tumor microenvironment in MM (Angelo Vacca - Bari) SLAMF7/CS1 (Nicola Giuliani - Parma) CD38: on target off tumor effects (Fabio Malavasi - Torino) The DARPIN bispecific molecule (Roberto Ria - Bari) Role of aminoacids degrading enzymes in lympho-proliferative disease (Francesco Di Raimondo - Catania) LECTURE: Deconstructing the molecular genetics of human cancer and its therapeutic implications (Pier Paolo Pandolfi - Harvard - USA) Key Points (Mario Luppi - Modena) Coffee break SESSION IV: PASSIVE IMMUNOTHERAPY: TARGETING THE IMMUNE MICROENVIRONMENT (Claudia Castellino - Cuneo, Michele Spina - Aviano - PN) PDI/PDL1 blockade in Hodgkin lymphoma (Armando Santoro - Rozzano - MI) PDI/PDL1 blockade in non-hodgkin lymphoma (Carmelo Carlo Stella - Milano) Mechanisms of resistance to ICP blockade (Barbara Castella - Torino - Cuneo) Targeting macrophages in amyloidosis (Giampaolo Merlini - Pavia) Key Points (Michele Spina - Aviano - PN) Lunch

4 SESSION V: ADOPTIVE IMMUNOTHERAPY: IN VIVO RECRUITMENT (Valter Gattei - Aviano - PN, Daniele Mattei - Cuneo) Blinatumumab in ALL and beyond: groundwork and outlook (Renato Bassan - Mestre - VE) DART: groundwork and outlook (Giorgio Inghirami - New York - USA) STING pathway activators (Massimo Di Nicola - Milano) Radiation and abscopal effect: lessons from solid tumors (Andrea Filippi - Pavia) Key Points (Valter Gattei - Aviano - PN) Coffee break SESSION VI: ADOPTIVE IMMUNOTHERAPY: EX-VIVO RECRUITMENT (Paolo Corradini - Milano, Roberto Sorasio - Cuneo) BET (Alessandro Rambaldi - Bergamo) Chimeric T cells (Luca Vago - Milano) CAR-T (Attilio Bondanza - Milano) CD1-restricted T cells (Giulia Casorati - Milano) Key points (Paolo Corradini - Milano)

5 Saturday, 19 May, 2018 SESSION VII: IMMUNE LESSONS FROM ALLO-HSCT (Francesca Bonifazi - Bologna, Nicola Mordini - Cuneo) Transplantation trends in Italy: outcome and complications (Francesca Bonifazi - Bologna) Alloreactivity of NK cells (Andrea Velardi - Perugia) Exploiting NK-cell alloreactivity in AML (Antonio Curti - Bologna) γδ T cells and more in HLA-haploidentical HSCT (Franco Locatelli - Roma) Mesenchimal Stem Cells (Maria Ester Bernardo - Milano) Tolerance induction combining T-cell depletion and posttransplant cyclophosphamide in non-ablative haploidentical HSCT (Franco Aversa - Parma) Key Points (Franco Locatelli - Roma) Coffee break SESSION VIII: TUMOR VACCINATION: WHERE WE STAND (Roberto Lemoli - Genova, Marco Merlano - Cuneo) LECTURE: Novel approaches of active immune therapy (Anas Younes - New York - USA) ALK+ lymphomas and beyond (Roberto Chiarle - Boston - Torino) Idiotypic vaccination: why we have failed 20 years ago (Massimo Massaia - Cuneo - Torino) Idiotypic vaccination: why we may succeed nowadays (Roberto Lemoli - Genova) Key Points (Roberto Lemoli - Genova) Goodbyes and meeting close (Massimo Massaia - Cuneo - Torino)

6 GENERAL INFORMATION Meeting Venue Provincia di Cuneo Centro Incontri Corso Dante Alighieri Cuneo, Italy Phone: Italian CME Credits A request for Italian CME credits have been made as follows: - Provider Studio ER Congressi SRL: ID n 14 CME credits for physicians (disciplines: Hematology, Oncology, Internal Medicine, Clinical Pathology) and biologists - Educational objective: guidelines-protocols-procedures. Registration Online registration: - Congressi 2018 The registration is free and includes: conference kit, partecipation in the scientific sessions, attendance certificate, coffee breaks, lunch, slides of the meeting. SCIENTIFIC SECRETARIAT Prof. Massimo Massaia SC Ematologia - AO S. Croce e Carle Via Michele Coppino Cuneo, Italy Laboratorio di Immunologia dei Tumori del Sangue (LITS) Centro Interdipartimentale di Ricerca in Biologia Molecolare (CIRBM) Università degli Studi di Torino massimo.massaia@unito.it ORGANIZING SECRETARIAT Studio E.R. Congressi Via Marconi, Bologna, Italy Phone Fax ercongressi@ercongressi.it UNDER THE AUSPICES OF SIE Società Italiana di Ematologia

Immunotherapy in Hematological Malignancies 2018

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