Registration Continental Breakfast. Histone Modifications and Cancer- Part 1

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1 Miami Epigenetics & Cancer Symposium Sunday, November 27 Tuesday, November 29, 2016 Ritz-Carlton, Miami Beach Conference Room: Collins for the Office SPEAKERS PROGRAM Sunday, November 27, 2016 Speakers arrive Monday, November 28, :00am-8:00am 8:00am-8:45am Registration Continental Breakfast 8:45am-9:00am Morning Session Salvador Benitah 9:00am-9:30am 9:30am-10:00am 10:00am-10:30am Introduction Stephen Nimer, M.D. Director, Sylvester Comprehensive Each session 20 mins presentation; 5 mins Q&A; 5 mins break Histone Modifications and Cancer- Part 1 Ari Melnick, M.D. - Weill Cornell Medical College Epigenetic circuits and their perturbation in lymphoid neoplasms Ali Shilatifard, Ph.D. - Northwestern University Enhancer Malfunction in Cancer Feng-Chun Yang, Ph.D., M.D. Sylvester Comprehensive Loss of Asxl2 leads to myeloid malignancies in mice 1 P a g e

2 10:30am-11:00am (30 mins) Histone Modifications and Cancer- Part 2 11:00am-11:30am 11:30am-12:00pm 12:00pm-12:30pm 12:30pm-3:00pm Short Talks Session Ramin Shiekhattar 2:00pm-2:15pm 2:15pm-2:30pm 2:30pm-2:45pm Afternoon Session Jean-Christophe Marine 3:00pm-3:30pm Scott Armstrong, M.D., Ph.D. - Dana-Farber Cancer Institute Targeting Epigenetic Mechanisms to Control Leukemic Gene Expression Shelley Berger, Ph.D. - University of Pennsylvania Epigenetic pathways as targets in human disease J. William Harbour, M.D. Sylvester Comprehensive Epigenetics of Uveal Melanoma Lunch: on your Own Each session 12 mins presentation; 3 mins Q&A Emerging Concepts François Fuks, Ph.D - ULB - Université Libre de Bruxelles Transcriptome-wide distribution and function of RNA hydroxymethylcytosine Tan Ince, M.D., Ph.D-Sylvester Comprehensive Cancer Regulation of Cancer Stem Cells by Histone Deacetylase (HDAC) Inhibitors David Shechter, Ph.D-Albert Einstein College of Medicine Arginine Methyltransferases in Cancer Transcriptional misregulation in Cancer- Part 1 Tony Kouzarides, Ph.D. University of Cambridge, United Kingdom Epigenetic modification of RNA 2 P a g e

3 3:30pm-4:00pm 4:00pm-4:30pm 4:30pm-5:00pm Lluis Morey, Ph.D. Sylvester Comprehensive Cancer PRC1 complexes in stem cells and cancer Christopher Vakoc, M.D., Ph.D. Cold Spring Harbor Chromatin regulators as cancer dependencies Transcriptional misregulation in Cancer- Part 2 5:00pm-5:30pm 5:30pm-6:00pm 6:00pm-7:30pm Salvador Aznar Benitah, Ph.D. - Institute for Research in Biomedicine, Barcelona H3K9me2 impacts adult stem cell function and mutational landscape in cancer Elsa Flores, Ph.D. - MD Anderson Drugging the p53 pathway through knowledge gained by manipulating p63 and p73 Cocktail Reception On-site: Ritz-Carlton, Miami Beach Tuesday, November 29, :00am-9:00am Morning Session Elsa Flores 9:00am-9:30am 9:30am-10:00am Continental Breakfast Enhancers and noncoding RNAs in Cancer- Part 1 Maria Figueroa, M.D. Sylvester Comprehensive Cancer Epigenetic deregulation in aging and MDS Luciano Di Croce, Ph.D. - for Genomic Regulation, Barcelona Gene regulation dynamics mediated by Polycomb complexes 3 P a g e

4 10:00am-10:30am 10:30am-11:00am Robert Kingston, Ph.D. Harvard Genetics Department Nucleosome compaction as a regulatory mechanism during development Enhancers and noncoding RNA in Cancer- Part 2 11:00am-11:30am 11:30am-12:00pm 12:00pm-2:00pm Jean-Christophe Marine, Ph.D. - VIB-KULeuven Cancer cell addiction to long noncoding RNAs Karen Adelman, Ph.D. Harvard Medical School Establishing Enhancer Landscapes Requires Collaboration between Transcription Factors, Chromatin Modifiers and Paused Pol II Lunch: on your Own Afternoon Session Maria Figueroa 2:00pm-2:30pm 2:30pm-3:30pm 3:30pm-4:00pm Epigenetics in Development and Disease- Part 1 Anne Brunet, Ph.D. Stanford University Epigenetic and metabolic regulation of aging Mingjiang Xu, M.D., Ph.D. Sylvester Comprehensive The catalytic activity of TET2 is essential for its myeloid malignancy-suppressive function in hematopoietic stem/progenitor cells likely through safeguarding genome mutagenicity Epigenetics in Development and Disease- Part 2 4:00pm-4:30pm 4:30pm-5:00pm Bradley Bernstein, M.D., Ph.D. Harvard University Epigenetic mechanisms of tumor initiation and evolution Jonathan Licht, M.D. University of Florida Disordered Histone Methylation in Lymphoid Malignancy 4 P a g e

5 Wednesday, November 30, 2016 Speakers departure day 5 P a g e