Organ site (ICD code) Exposure categories cases/ deaths. Men Tire material handling

Transcription

1 categories Chen et al (997), PR China 788 workers (5 men, 2798 women) employed > year in 3 factories, through 972 Work history and payroll data from Tire material handling SIR 2. (p<.5) Results stratified by smoker/nonsmoker. Cancer incidence data and confirmed through hospital of diagnosis Li and Yu (22b), PR China Case-cohort ; 598 workers (934 men, 664 women) employed > year in a rubber plant from ; sub-cohort of 88 workers, frequencymatched by year of birth within years; vital status % Work history from and questionnaire; jobs coded in 4 categories, cumulative years Annual income Low Job category and years Inner tire tube Milling, etc Trend (p=.4) 2.4 (.-5.8) 5.2 (.4-8.9).5 (.2-4.3).7 (.2-5.4).5 (.-2.8).3 (.6-2.8) Work groups, gender and income; not adjusted for smoking, for smokers >2 packyears:.3 (.4-3.8) Reference category is nonexposed

2 categories Mundt et al (999), 287 female workers employed > year in 5 rubber plants and actively employed from ; 976-9; vital status 99%; cause of death 94% Work history reconstructed from archived cost center codes. Classified into 6 work areas by type and stage of process Year of hire < > (.6-3.2) (.8-5.9). al. (996); al. (998); (998); (999); (2a); (2b), 8933 German male workers aged <85 years, employed > year in 5 rubber plants from 95-98; 98-9; vital status 99%; cause of death 97% Retrospective semiquantitative reconstruction of nitrosamines, asbestos, talc and carbon black using individual work histories and limited IH air measurements; low workers were employed <.5 year in high/medium s, high were employed > years in high s Asbestos/talc Low High (.9-.6) H..9 (.9-4.) 3.9 (.2-2.6) H adjusted for age and all other s; - year lagging; 2

3 categories Neves et al. (26), Sao Paulo, Brazil 988 male workers from 743 rubber companies employed from ; 99-2; vital status 83%; cause of death 8% Classification by company size, type of rubber industry, occupational title, and qualification, union records Company size Large Small 7..2 (.8-.7) 3.5 ( ) Age, time since first employment, total duration of employment in rubber industry; - year lagging Internal comparisons Straughan and Sorahan (2); Dost et al. (27), United Kingdom BRMA health research project II 865 workers of 4 rubber plants (756 men, 9 women) employed > year during , office workers were excluded; mortality and incidence followup ; vital status 98% Workers considered exposed if employed in rubber manufacture; period from hire as surrogate for cumulative 4.9 (.2-2.2) S.4 (.7-2.5) Stratification by industry sector (tire manufacture or general rubber goods) Wilczyńska et al. (2), de Vocht et al. (29), 7636 workers (582 men, 654 women) employed >3 months during in a rubber tire plant; 95-2; vital status 97%; cause of death 88% JEM for to aromatic amines, inhalable aerosols and rubber fumes from a database of data for the European rubber industry Maintenance department (.7-.2).3 (.8-2.) 5-year lagging, gender-specific analyses No increase in risk with to aromatic amines and inhalable aerosol 3

4 categories Chow et al. (995), Sweden employed in 96; cancer incidence follow-up 96-79; 2394 oesophageal cancer cases, 96% histologically confirmed Employment information (industry and occupation) from 96 census Employed in rubber Employed in vulcanizing shops 5 9 SIR.4 (p>.5) 4.7 (p<.) Geographic region National reference al. (996); al. (998); (998); (999); (2a); (2b), 8933 German male workers aged <85 years, employed > year in 5 rubber plants from 95-98; 98-9; vital status 99%; cause of death 97% Retrospective semiquantitative reconstruction of nitrosamines, asbestos, talc and carbon black using individual work histories and limited IH air measurements; low workers were employed <.5 year in high/medium s, high were employed > years in high s Nitrosamines Low High (.9-.6) H. 2.7 (.7-.5) 9. ( ) p<.5 H adjusted for age and all other s; - year lagging; 4

5 categories et al (99), et al (995), Szymczak et al. (23), 342 workers (5472 men, 587 women) employed > year during in a rubber footwear plant; until 997 Occupational history from 7.7 (.-2.8) National reference Straughan and Sorahan (2); Dost et al. (27), England and Wales and Scotland, UK, BRMA health research project II 865 workers of 4 rubber plants (756 men, 9 women) employed > year during , office workers were excluded; mortality and incidence followup ; vital status 98% Workers considered exposed if employed in rubber manufacture; period from hire as surrogate for cumulative 6 7. (.4-2.3) S.2 (.5-2.5) Stratification by industry sector (tire manufacture or general rubber goods) Other digestive cancer sites Chen et al (997), Shanghai, China 788 workers (5 men, 2798 women) employed > year in 3 factories, through 972 Work history and payroll data from Rectum Tire building/tire storage Tire building 4 6 SIR 4.8 (p<.5) 3.4 (p<.5) Results stratified by smoker/nonsmoker. Cancer incidence data and confirmed through hospital of diagnosis 5

6 categories et al (99), et al (995), Szymczak et al. (23), 342 workers (5472 men, 587 women) employed > year during in a rubber footwear plant; until 997 Occupational history from Colon Rectum and anus (.-2.8).7 (.-2.5) National reference Neves et al. (26), Sao Paulo, Brazil 988 male workers from 743 rubber companies employed from ; 99-2; vital status 83%; cause of death 8% Classification by company size, type of rubber industry, occupational title, and qualification, union records Upper digestive tract Company size Large Small Changed size (.7-3.2) 2.5 (.8-3.5) 3.9 (3.-5.) Age, time since first employment, total duration of employment in rubber industry; - year lagging Internal comparisons Taeger et al. (27), west 9597 workers (8,2 men,,387 women) employed in 3 rubber facilities during 98-2; mortality followup 982-2, censored at age 85 years Workers considered exposed if employed in rubber manufacture Oral cavity.6 (.4-8.9) Genderspecific analyses ; no bladder cancer observed 6

7 categories Wilczyńska et al. (2), de Vocht et al. (29), 7636 workers (582 men, 6,54 women) employed >3 months during in a rubber tire plant; 95-2; vital status 97%; cause of death 88% JEM for to aromatic amines, inhalable aerosols and rubber fumes from a database of data for the European rubber industry Digestive organs and peritoneum (5-59) Quartiles Aromatic amines I II III IV (.4-5.) 2. (.5-7.6).5 (.4-5.5) 5-year lagging, gender-specific analyses H-hazard rate ratio, OR-odds ratio, -relative risk, SIR-standardized incidence ratio, -standardized mortality ratio, S-standardized rate ratio risk estimate not reported. 7