Lymphoma and Myeloma Kris3ne Kra4s, M.D.

Size: px
Start display at page:

Download "Lymphoma and Myeloma Kris3ne Kra4s, M.D."

Transcription

1 Lymphoma and Myeloma Kris3ne Kra4s, M.D.

2 Hematologic Malignancies Leukemia Malignancy of hematopoie3c cells Starts in bone marrow, can spread to blood, nodes Myeloid or lymphoid Acute or chronic Lymphoma Malignancy of hematopoie3c cells Starts in lymph nodes, can spread to blood, marrow Lymphoid only Hodgkin or non- Hodgkin

3

4 Hematologic Malignancies Leukemias Acute leukemias Chronic leukemias Lymphomas Hodgkin lymphoma Non- Hodgkin lymphoma Plasma cell disorders Mul3ple myeloma

5 Hematologic Malignancies Leukemias Acute leukemias Chronic leukemias Lymphomas Hodgkin lymphoma Non- Hodgkin lymphoma

6 Lymphadenopathy

7 Lymphadenopathy

8 Causes of lymphadenopathy Most common cause overall: benign reac3on to infec3on Most common malignant cause: metasta3c carcinoma

9 Lymph node anatomy

10 Reac3ve lymph node

11 Reac3ve lymph node

12 Reac3ve lymph node

13 Benign (L) vs. malignant (R)

14 Non- Hodgkin Lymphoma Malignant prolifera3on of lymphoid cells (blasts or mature cells) in lymph nodes Skips around Many subtypes Most are B cell Things you must know

15 Symptoms of NHL Painless, firm lymphadenopathy Extranodal manifesta3ons B symptoms: weight loss, night sweats, fever

16 NHL presen3ng as gingival lesion

17 NHL involving gingiva

18 NHL presen3ng as palatal lesion

19 Features of Low- Grade vs. High- Grade NHL Low- grade High- grade Older pa3ents Indolent (incurable!) Small, mature cells Non- destruc3ve Children, some3mes Aggressive (curable?) Big, ugly cells Destruc3ve

20 Types of NHL Low- grade High- grade Small lymphocy3c lymphoma Malt lymphoma Follicular lymphoma Mycosis fungoides Large cell lymphoma Lymphoblas3c lymphoma BurkiW lymphoma

21 Small Lymphocy3c Lymphoma Things you must know Small mature lymphocytes Same thing as CLL CD5+ Long course; death from infec3on

22 Small lymphocy3c lymphoma

23 Small lymphocy3c lymphoma

24 MALT Lymphoma Things you must know Occurs in mucosa- associated lymphoid 3ssue Associated with Helicobacter pylori Early on, can be cured with an3bio3cs

25 MALT lymphoma

26 MALT lymphoma

27 Follicular Lymphoma Things you must know Follicular pawern (later diffuse) Small cleaved cell, mixed or large cell Grade 1, 2, or3 t(14;18) - IgH and bcl- 2

28 Follicular lymphoma

29 I II Follicular lymphoma III

30 Follicular lymphoma

31 Staging and Prognosis of Follicular Lymphoma Stage I Stage II Stage III Stage IV Single node Two or more nodes on same side of diaphragm Lymph nodes on both sides of the diaphragm Diffuse extranodal involvement 90% 5ys 40% 5ys A = no addi3onal symptoms B = weight loss, night sweats, fever

32 Mycosis Fungoides/Sézary Syndrome Things you must know Skin lesions Blood involvement Cerebriform lymphocytes T- cell immunophenotype

33 Mycosis fungoides/sézary syndrome

34 Mycosis fungoides/sézary syndrome

35 Mycosis fungoides/sézary syndrome

36 Mycosis fungoides/sézary syndrome

37 Mycosis fungoides/sézary syndrome

38 Mycosis fungoides/sézary syndrome

39 Diffuse Large- Cell Lymphoma Things you must know Large B cells Extranodal involvement Grows rapidly Bad prognosis

40 Diffuse large- cell lymphoma

41 Diffuse large- cell lymphoma

42 Lymphoblas3c Lymphoma Things you must know Typical pa3ent: teenage male with medias3nal mass Lymphoblasts in diffuse pawern Same as ALL* * Which kinds of ALL?

43 T- Lymphoblas3c lymphoma

44 T- cell lymphoblas3c lymphoma/t- cell ALL

45 BurkiW Lymphoma Things you must know Children, young adults Fast- growing Extranodal mass Starry- sky pawern

46 BurkiW lymphoma

47 BurkiW lymphoma

48 BurkiW lymphoma

49 Hodgkin Lymphoma Things you must know Younger pa3ents, good prognosis Con3guous spread Five subtypes Reed- Sternberg cell

50 Hodgkin lymphoma

51 Reed- Sternberg cell

52 Hodgkin lymphoma

53 Clinical Features of Hodgkin Lymphoma Younger pa3ents Disease o4en localized Prognosis generally good Danger: second malignancies

54 Mul3ple Myeloma Things you must know Malignant prolifera3on of plasma cells Monoclonal gammopathy Decreased normal immunoglobulins Osteoly3c lesions

55 Clinical Features of Mul3ple Myeloma Weakness Infec3ons Renal failure Bone pain Hypercalcemia

56 Mul3ple Myeloma

57 Mul3ple Myeloma

58 Mul3ple Myeloma

59 Mul3ple Myeloma

60 Mul3ple Myeloma

61 Serum protein electrophoresis

62 Serum protein electrophoresis

63 Serum protein electrophoresis

64 Treatment of Mul3ple Myeloma Chemo and radia3on Bone marrow transplant 5 year survival with chemo only: 20%

Non-Hodgkin lymphomas (NHLs) Hodgkin lymphoma )HL)

Non-Hodgkin lymphomas (NHLs) Hodgkin lymphoma )HL) Non-Hodgkin lymphomas (NHLs) Hodgkin lymphoma )HL) Lymphoid Neoplasms: 1- non-hodgkin lymphomas (NHLs) 2- Hodgkin lymphoma 3- plasma cell neoplasms Non-Hodgkin lymphomas (NHLs) Acute Lymphoblastic Leukemia/Lymphoma

More information

Large cell immunoblastic Diffuse histiocytic (DHL) Lymphoblastic lymphoma Diffuse lymphoblastic Small non cleaved cell Burkitt s Non- Burkitt s

Large cell immunoblastic Diffuse histiocytic (DHL) Lymphoblastic lymphoma Diffuse lymphoblastic Small non cleaved cell Burkitt s Non- Burkitt s Non Hodgkin s Lymphoma Introduction 6th most common cause of cancer death in United States. Increasing in incidence and mortality. Since 1970, the incidence of has almost doubled. Overview The types of

More information

What is a hematological malignancy? Hematology and Hematologic Malignancies. Etiology of hematological malignancies. Leukemias

What is a hematological malignancy? Hematology and Hematologic Malignancies. Etiology of hematological malignancies. Leukemias Hematology and Hematologic Malignancies Cancer of the formed elements of the blood What is a hematological malignancy? A hematologic malignancy is a malignancy (or cancer) of any of the formed elements

More information

7 Omar Abu Reesh. Dr. Ahmad Mansour Dr. Ahmad Mansour

7 Omar Abu Reesh. Dr. Ahmad Mansour Dr. Ahmad Mansour 7 Omar Abu Reesh Dr. Ahmad Mansour Dr. Ahmad Mansour -Leukemia: neoplastic leukocytes circulating in the peripheral bloodstream. -Lymphoma: a neoplastic process in the lymph nodes, spleen or other lymphatic

More information

Lymphoma: What You Need to Know. Richard van der Jagt MD, FRCPC

Lymphoma: What You Need to Know. Richard van der Jagt MD, FRCPC Lymphoma: What You Need to Know Richard van der Jagt MD, FRCPC Overview Concepts, classification, biology Epidemiology Clinical presentation Diagnosis Staging Three important types of lymphoma Conceptualizing

More information

Burkitt lymphoma. Sporadic Endemic in Africa associated with EBV Translocations involving MYC gene on chromosome 8

Burkitt lymphoma. Sporadic Endemic in Africa associated with EBV Translocations involving MYC gene on chromosome 8 Heme 8 Burkitt lymphoma Sporadic Endemic in Africa associated with EBV Translocations involving MYC gene on chromosome 8 Most common is t(8;14) Believed to be the fastest growing tumor in humans!!!! Morphology

More information

LEUKAEMIA and LYMPHOMA. Dr Mubarak Abdelrahman Assistant Professor Jazan University

LEUKAEMIA and LYMPHOMA. Dr Mubarak Abdelrahman Assistant Professor Jazan University LEUKAEMIA and LYMPHOMA Dr Mubarak Abdelrahman Assistant Professor Jazan University OBJECTIVES Identify etiology and epidemiology for leukemia and lymphoma. Discuss common types of leukemia. Distinguish

More information

Lymphatic system component

Lymphatic system component Introduction Lymphatic system component Statistics Overview Lymphoma Non Hodgkin s Lymphoma Non- Hodgkin's is a type of cancer that originates in the lymphatic system. It is estimated to be the sixth most

More information

Low grade High grade , immune suppression chronic persistent inflammation viruses B-symptoms

Low grade High grade , immune suppression chronic persistent inflammation viruses B-symptoms We've one category for lymphoid neoplasm which is the lymphoma in contrast to that of myeloid which has three categories; acute myeloid leukemias, myeloproliferative & myelodysplastic disorders. Lymphoma

More information

Lymphoma/CLL 101: Know your Subtype. Dr. David Macdonald Hematologist, The Ottawa Hospital

Lymphoma/CLL 101: Know your Subtype. Dr. David Macdonald Hematologist, The Ottawa Hospital Lymphoma/CLL 101: Know your Subtype Dr. David Macdonald Hematologist, The Ottawa Hospital Function of the Lymph System Lymph Node Lymphocytes B-cells develop in the bone marrow and influence the immune

More information

HENATOLYMPHOID SYSTEM THIRD YEAR MEDICAL STUDENTS- UNIVERSITY OF JORDAN AHMAD T. MANSOUR, MD. Parts 2 and 3

HENATOLYMPHOID SYSTEM THIRD YEAR MEDICAL STUDENTS- UNIVERSITY OF JORDAN AHMAD T. MANSOUR, MD. Parts 2 and 3 HENATOLYMPHOID SYSTEM THIRD YEAR MEDICAL STUDENTS- UNIVERSITY OF JORDAN AHMAD T. MANSOUR, MD Parts 2 and 3 NEOPLASTIC LYMPHOID DISEASES Introduction o The bone marrow is the source of all cells in the

More information

LYMPHOMA DIAGNOSIS and PROGNOSIS. LC Lim Dept of Hematology Singapore General Hospital

LYMPHOMA DIAGNOSIS and PROGNOSIS. LC Lim Dept of Hematology Singapore General Hospital LYMPHOMA DIAGNOSIS and PROGNOSIS LC Lim Dept of Hematology Singapore General Hospital OUTLINE Accurate diagnosis Define subtype : WHO classification Staging : Defines extent of involvement Prognosis Determining

More information

Understanding your diagnosis. Dr Graham Collins Consultant Haemtologist Oxford University Hospitals

Understanding your diagnosis. Dr Graham Collins Consultant Haemtologist Oxford University Hospitals Understanding your diagnosis Dr Graham Collins Consultant Haemtologist Oxford University Hospitals Common questions I get asked What is lymphoma? What subtype do I have and what does that mean? What are

More information

LYMPHOMAS an overview of some subtypes of NHLs

LYMPHOMAS an overview of some subtypes of NHLs One of the confusing aspects of the lymphoid neoplasms concerns the use of the descriptive terms "leukemia" and "lymphoma." LYMPHOMAS an overview of some subtypes of NHLs Leukemia is used for lymphoid

More information

Pathology of Hematopoietic and Lymphoid tissue

Pathology of Hematopoietic and Lymphoid tissue CONTENTS Pathology of Hematopoietic and Lymphoid tissue White blood cells and lymph nodes Quantitative disorder of white blood cells Reactive lymphadenopathies Infectious lymphadenitis Tumor metastasis

More information

Plasma cell myeloma (multiple myeloma)

Plasma cell myeloma (multiple myeloma) Plasma cell myeloma (multiple myeloma) Common lymphoid neoplasm, present at old age (70 years average) Remember: plasma cells are terminally differentiated B-lymphocytes that produces antibodies. B-cells

More information

WHO Classification. B-cell chronic lymphocytic leukemia/small T-cell granular lymphocytic leukemia

WHO Classification. B-cell chronic lymphocytic leukemia/small T-cell granular lymphocytic leukemia Blood Malignancies-II Prof. Dr. Herman Hariman, a Ph.D, SpPK (KH). Prof. Dr. Adikoesoema Aman, SpPK (KH) Dept. of Clinical Pathology, School of Medicine, University of North Sumatra WHO classification

More information

Classifications of lymphomas

Classifications of lymphomas Classifications of lymphomas Lukes and Collins Kiel classification Working formulation REAL classification (1994) WHO classification (2000) WHO CLASSIFICATIONF OF NEOPLASMS HAEMATOPETIC AND LYMPHOID TISSUES

More information

Blood Cancers. Blood Cells. Blood Cancers: Progress and Promise. Bone Marrow and Blood. Lymph Nodes and Spleen

Blood Cancers. Blood Cells. Blood Cancers: Progress and Promise. Bone Marrow and Blood. Lymph Nodes and Spleen Blood Cancers: Progress and Promise Mike Barnett & Khaled Ramadan Division of Hematology Department of Medicine Providence Health Care & UBC Blood Cancers Significant health problem Arise from normal cells

More information

Pathology #07. Hussein Al-Sa di. Dr. Sohaib Al-Khatib. Mature B-Cell Neoplasm. 0 P a g e

Pathology #07. Hussein Al-Sa di. Dr. Sohaib Al-Khatib. Mature B-Cell Neoplasm. 0 P a g e Pathology #07 Mature B-Cell Neoplasm Hussein Al-Sa di Dr. Sohaib Al-Khatib 0 P a g e Thursday 18/2/2016 Our lecture today (with the next 2 lectures) will be about lymphoid tumors This is a little bit long

More information

Update in Lymphoma Imaging

Update in Lymphoma Imaging Update in Lymphoma Imaging Victorine V. Muse, MD Lymphoma Update in Lymphoma Imaging Victorine V Muse, MD Heterogeneous group of lymphoid neoplasms divided into two broad histological categories Hodgkin

More information

Pathology of Hematopoietic and Lymphoid tissue

Pathology of Hematopoietic and Lymphoid tissue Pathology of Hematopoietic and Lymphoid tissue Peerayut Sitthichaiyakul, M.D. Department of Pathology and Forensic Medicine Faculty of Medicine, Naresuan University CONTENTS White blood cells and lymph

More information

HAEMATOLOGICAL MALIGNANCY

HAEMATOLOGICAL MALIGNANCY HAEMATOLOGICAL MALIGNANCY Reference Compulsory reading Haematology at Glance 2 nd ed. Atul Mehta & Victor Hoffbrand Chapters: 20 to 31 Pages: 46 to 69 Pathogenesis of Haematological Malignancy Figure (a)

More information

Lymphatic System Disorders

Lymphatic System Disorders Lymphatic System Disorders Lymphomas Malignant neoplasms involving lymphocyte proliferation in lymph nodes Specific causes not identified // Higher risk in adults who received radiation during childhood

More information

WHAT ARE PAEDIATRIC CANCERS

WHAT ARE PAEDIATRIC CANCERS WHAT ARE PAEDIATRIC CANCERS INTRODUCTION Childhood cancers are RARE 0.5% of all cancers in the West Overall risk that a child will develop cancer during first 15 years of life is 1 in 450 and 1 in 600

More information

Indolent Lymphomas. Dr. Melissa Toupin The Ottawa Hospital

Indolent Lymphomas. Dr. Melissa Toupin The Ottawa Hospital Indolent Lymphomas Dr. Melissa Toupin The Ottawa Hospital What does indolent mean? Slow growth Often asymptomatic Chronic disease with periods of relapse (long natural history possible) Incurable with

More information

Page 1 of 9 Title Authored By Course No Contact Hours 2 ABCs of Lymphoma Anita Rothera RNC, BS, CDE LYM020108 Purpose The goal of this course is to help health care professionals learn about the different

More information

Overview of Cutaneous Lymphomas: Diagnosis and Staging. Lauren C. Pinter-Brown MD, FACP Health Sciences Professor of Medicine and Dermatology

Overview of Cutaneous Lymphomas: Diagnosis and Staging. Lauren C. Pinter-Brown MD, FACP Health Sciences Professor of Medicine and Dermatology Overview of Cutaneous Lymphomas: Diagnosis and Staging Lauren C. Pinter-Brown MD, FACP Health Sciences Professor of Medicine and Dermatology Definition of Lymphoma A cancer or malignancy that comes from

More information

LYMPHOPROLIFERATIVE DISORDERS. Dr Mere Kende MBBS, MMED (Path), MACTM, MACRRM, MAACB Lecturer: SMHS, UPNG

LYMPHOPROLIFERATIVE DISORDERS. Dr Mere Kende MBBS, MMED (Path), MACTM, MACRRM, MAACB Lecturer: SMHS, UPNG LYMPHOPROLIFERATIVE DISORDERS Dr Mere Kende MBBS, MMED (Path), MACTM, MACRRM, MAACB Lecturer: SMHS, UPNG Outline What are lymphoproliferative Disorders? Examples of LPD Classification Causes Clinical Features

More information

LYMPHOMA Joginder Singh, MD Medical Oncologist, Mercy Cancer Center

LYMPHOMA Joginder Singh, MD Medical Oncologist, Mercy Cancer Center LYMPHOMA Joginder Singh, MD Medical Oncologist, Mercy Cancer Center Lymphoma is cancer of the lymphatic system. The lymphatic system is made up of organs all over the body that make up and store cells

More information

Lymphoma: The Basics. Dr. Douglas Stewart

Lymphoma: The Basics. Dr. Douglas Stewart Lymphoma: The Basics Dr. Douglas Stewart Objectives What is lymphoma? How common is it? Why does it occur? How do you diagnose it? How do you manage it? How do you follow patients after treatment? What

More information

Indolent Lymphomas: Current. Dr. Laurie Sehn

Indolent Lymphomas: Current. Dr. Laurie Sehn Indolent Lymphomas: Current Dr. Laurie Sehn Why does indolent mean? Slow growth Often asymptomatic Chronic disease with periods of relapse (long natural history possible) Incurable with current standard

More information

Lymphomas and multiple myeloma 12/23/2018 1

Lymphomas and multiple myeloma 12/23/2018 1 60 Lymphomas and multiple myeloma 12/23/2018 1 Lymphomas Lymphoma is cancer of the lymphatic system. Lymphomas are subdivided into two main categories: Hodgkin's lymphoma (HL) and non- Hodgkin's lymphoma

More information

Hematologic Malignancies. Anna Schaal, RN, MSN, arnp Norris Cotton Cancer Center Lebanon, New Hampshire

Hematologic Malignancies. Anna Schaal, RN, MSN, arnp Norris Cotton Cancer Center Lebanon, New Hampshire Hematologic Malignancies Anna Schaal, RN, MSN, arnp Norris Cotton Cancer Center Lebanon, New Hampshire Objectives At the end of the session, the oncology nurse will be able to: Explain the pathophysiology

More information

Non-Hodgkin Lymphoma. Protocol applies to non-hodgkin lymphoma involving any organ system except the gastrointestinal tract.

Non-Hodgkin Lymphoma. Protocol applies to non-hodgkin lymphoma involving any organ system except the gastrointestinal tract. Non-Hodgkin Lymphoma Protocol applies to non-hodgkin lymphoma involving any organ system except the gastrointestinal tract. Protocol revision date: January 2005 No AJCC/UICC staging system Procedures Cytology

More information

Monsanto s Spin on its Roundup herbicide is Unwinding

Monsanto s Spin on its Roundup herbicide is Unwinding Monsanto s Spin on its Roundup herbicide is Unwinding By: Thomas T. Dunbar, Esq. Recently, information about the potential danger posed by Monsanto s Roundup has surfaced as a result of information discovered

More information

Classification of Hematologic Malignancies. Patricia Aoun MD MPH

Classification of Hematologic Malignancies. Patricia Aoun MD MPH Classification of Hematologic Malignancies Patricia Aoun MD MPH Objectives Know the basic principles of the current classification system for hematopoietic and lymphoid malignancies Understand the differences

More information

The Lymphomas. An overview..

The Lymphomas. An overview.. The Lymphomas An overview.. Peter Anglin MD, FRCPC, MBA Stronach Regional Cancer Centre Newmarket, ON The lymphomas are an important part of the history of medicine 1666 Magpighi publishes first recorded

More information

Harmesh Naik, MD. GME Presentation to Family Practice Residents October 16, 2013.

Harmesh Naik, MD. GME Presentation to Family Practice Residents October 16, 2013. Harmesh Naik, MD. GME Presentation to Family Practice Residents October 16, 2013. Lymphoma: Lympho-proliferative disorders arising from lymphocytes Heterogeneous group of disorders Differing patterns of

More information

Retroperitoneal lymphoma mixed cell type icd 10

Retroperitoneal lymphoma mixed cell type icd 10 Retroperitoneal lymphoma mixed cell type icd 10 The Borg System is 100 % Retroperitoneal lymphoma mixed cell type icd 10 Lymphoma, non hodgkins, stage 1; Lymphoma, non hodgkins, stage 2; Lymphoma, non

More information

Blood Cancers in the Community

Blood Cancers in the Community Over to you, mate Blood Cancers in the Community National Rural Health Conference NZ Rural General Practice Network April 7, 2018 Brian Grainger Haematology Registrar Auckland Acknowledgements Dr James

More information

a resource for physicians Recommended Referral Timing for Stem Cell Transplant Evaluation

a resource for physicians Recommended Referral Timing for Stem Cell Transplant Evaluation a resource for physicians Recommended Referral Timing for Stem Cell Transplant Evaluation This resource has been developed to help guide you regarding the appropriate timing and conditions for a referral

More information

Bone Marrow. Procedures Blood Film Aspirate, Cell Block Trephine Biopsy, Touch Imprint

Bone Marrow. Procedures Blood Film Aspirate, Cell Block Trephine Biopsy, Touch Imprint Bone Marrow Protocol applies to acute leukemias, myelodysplastic syndromes, myeloproliferative disorders, chronic lymphoproliferative disorders, malignant lymphomas, plasma cell dyscrasias, histiocytic

More information

Lymphoid Neoplasms. Sylvie Freeman Department of Clinical Immunology, University of Birmingham

Lymphoid Neoplasms. Sylvie Freeman Department of Clinical Immunology, University of Birmingham Lymphoid Neoplasms Sylvie Freeman Department of Clinical Immunology, University of Birmingham Incidence of Haematological Malignancies UK2001 (CRUK) Malignancy New Cases All Cancers 271,000 Leukaemia 6,760

More information

Reac%ve and Benign Flow Cytometry findings

Reac%ve and Benign Flow Cytometry findings Reac%ve and Benign Flow Cytometry findings Lymph nodes and other /ssues Sindhu Cherian, MD University of Washington, Sea

More information

Small B-cell (Histologically Low Grade) Lymphoma

Small B-cell (Histologically Low Grade) Lymphoma Frequency of Lymphoid Neoplasms Small B-cell (Histologically Low Grade) Lymphoma Stephen Hamilton-Dutoit Institute of Pathology Aarhus University Hospital B-cell neoplasms 88% Diffuse large B-cell lymphoma

More information

Nodular lymphocyte predominant Hodgkin lymphoma. Lymphoma Tumor Board. January 5, 2018

Nodular lymphocyte predominant Hodgkin lymphoma. Lymphoma Tumor Board. January 5, 2018 Nodular lymphocyte predominant Hodgkin lymphoma Lymphoma Tumor Board January 5, 2018 Etiology Subtypes of Classical Hodgkin Lymphoma (chl)* Nodular sclerosing HL Most common subtype Composed of large tumor

More information

Early diagnosis saves lives #SpotLeukaemia

Early diagnosis saves lives #SpotLeukaemia Early diagnosis saves lives #SpotLeukaemia Leukaemia... is a blood cancer affects people of all ages Leukaemia symptoms are hard to spot, as they are similar to the symptoms of common, unrelated conditions.

More information

Lymphoma 101. Nathalie Johnson, MDPhD. Division of Hematology Jewish General Hospital Associate Professor of Medicine, McGill University

Lymphoma 101. Nathalie Johnson, MDPhD. Division of Hematology Jewish General Hospital Associate Professor of Medicine, McGill University Lymphoma 101 Nathalie Johnson, MDPhD Division of Hematology Jewish General Hospital Associate Professor of Medicine, McGill University Disclosures Consultant and Advisory boards for multiple companies

More information

Neoplastic proliferation arising from white blood cells. Introductory remarks. Classification

Neoplastic proliferation arising from white blood cells. Introductory remarks. Classification Neoplastic proliferation arising from white blood cells Lymphoproliferative and myeloproliferative diseases and syndromes Oliver Rácz, 2012-2017 1 Introductory remarks Leukemia and lymphoma are old descriptive

More information

Incidental Absolute Leukocytosis Connie Shen, MS2

Incidental Absolute Leukocytosis Connie Shen, MS2 Incidental Absolute Leukocytosis Connie Shen, MS2 Clinical History An otherwise healthy 73-year-old Caucasian man presents for a rou=ne physical. Review of systems is nega=ve. A CBC was obtained and reveals

More information

88-year-old Female with Lymphadenopathy. Faizi Ali, MD

88-year-old Female with Lymphadenopathy. Faizi Ali, MD 88-year-old Female with Lymphadenopathy Faizi Ali, MD Clinical History A 88-year-old caucasian female presented to our hospital with the complaints of nausea, vomiting,diarrhea, shortness of breath and

More information

2010 Hematopoietic and Lymphoid ICD-O Codes - Alphabetical List THIS TABLE REPLACES ALL ICD-O-3 Codes

2010 Hematopoietic and Lymphoid ICD-O Codes - Alphabetical List THIS TABLE REPLACES ALL ICD-O-3 Codes Acute basophilic leukemia 9870/3 Acute biphenotypic leukemia [OBS] 9805/3 Acute erythroid leukemia 9840/3 Acute megakaryoblastic leukemia 9910/3 Acute monoblastic and monocytic leukemia 9891/3 Acute myeloid

More information

2012 Hematopoietic and Lymphoid ICD-O Codes - Numerical List THIS TABLE REPLACES ALL ICD-O-3 Codes

2012 Hematopoietic and Lymphoid ICD-O Codes - Numerical List THIS TABLE REPLACES ALL ICD-O-3 Codes Malignant lymphoma, NOS 9590/3 Non-Hodgkin lymphoma, NOS 9591/3 B-cell lymphoma, unclassifiable, with features intermediate between diffuse large B-cell lymphoma and classical Hodgkin lymphoma 9596/3 Primary

More information

Immunopathology of Lymphoma

Immunopathology of Lymphoma Immunopathology of Lymphoma Noraidah Masir MBBCh, M.Med (Pathology), D.Phil. Department of Pathology Faculty of Medicine Universiti Kebangsaan Malaysia Lymphoma classification has been challenging to pathologists.

More information

Lymphoma. Multiple myeloma.

Lymphoma. Multiple myeloma. Lymphoma. Multiple myeloma. Lymphogranulomatosis (Hodgkin's disease, Hodgkin's lymphoma). Hodgkin's Lymphoma, lymphogranulomatosis (LGM) is tumor disease, initially localized in lymphoid tissue, substratum

More information

Haematological malignancies in England Cancers Diagnosed Haematological malignancies in England Cancers Diagnosed

Haematological malignancies in England Cancers Diagnosed Haematological malignancies in England Cancers Diagnosed Northern and Yorkshire Cancer Registry and Information Service Haematological malignancies in England Cancers Diagnosed 2001-2008 Haematological 2001-2008 Malignancies www.nycris.nhs.uk www.nycris.nhs.uk

More information

Surviving Leukemia And Hodgkin's Lymphoma: An Overview Of Effective Treatment Methods By Melinda Baxter

Surviving Leukemia And Hodgkin's Lymphoma: An Overview Of Effective Treatment Methods By Melinda Baxter Surviving Leukemia And Hodgkin's Lymphoma: An Overview Of Effective Treatment Methods By Melinda Baxter Low-grade non-hodgkin's lymphoma (NHL) is an indolent form of the disease with a Adverse effects

More information

PROBLEMS OF THE HEMATOLOGICAL SYSTEM

PROBLEMS OF THE HEMATOLOGICAL SYSTEM PROBLEMS OF THE HEMATOLOGICAL SYSTEM UNIT 5 Review A & P of Hematological system Outline focused exam Differentiate and start to evaluate diagnostic exams used to assess problems of the hematological system

More information

Lymphoma: What You Need to Know

Lymphoma: What You Need to Know Lymphoma: What You Need to Know www.lymphoma.org.au Lymphoma What You Need to Know Whilst Lymphoma Australia (LA) has made every effort to confirm the accuracy of the information contained herein, it makes

More information

During past decades, because of the lack of knowledge

During past decades, because of the lack of knowledge Staging and Classification of Lymphoma Ping Lu, MD In 2004, new cases of non-hodgkin s in the United States were estimated at 54,370, representing 4% of all cancers and resulting 4% of all cancer deaths,

More information

Change Summary - Form 2018 (R3) 1 of 12

Change Summary - Form 2018 (R3) 1 of 12 Summary - Form 2018 (R3) 1 of 12 Form Question Number (r3) Type Description New Text Previous Text Today's date was removed 2018 N/A Today's Date Removed from Key Fields 2018 N/A HCT Type 2018 N/A Product

More information

A CASE OF PRIMARY THYROID LYMPHOMA. Prof Dr.Dilek Gogas Yavuz Marmara University School of Medicine Endocrinology and Metabolism Istanbul, Turkey

A CASE OF PRIMARY THYROID LYMPHOMA. Prof Dr.Dilek Gogas Yavuz Marmara University School of Medicine Endocrinology and Metabolism Istanbul, Turkey A CASE OF PRIMARY THYROID LYMPHOMA Prof Dr.Dilek Gogas Yavuz Marmara University School of Medicine Endocrinology and Metabolism Istanbul, Turkey 38 year old female She recognized a mass in her right neck

More information

Differential diagnosis of hematolymphoid tumors composed of medium-sized cells. Brian Skinnider B.C. Cancer Agency, Vancouver General Hospital

Differential diagnosis of hematolymphoid tumors composed of medium-sized cells. Brian Skinnider B.C. Cancer Agency, Vancouver General Hospital Differential diagnosis of hematolymphoid tumors composed of medium-sized cells Brian Skinnider B.C. Cancer Agency, Vancouver General Hospital Lymphoma classification Lymphoma diagnosis starts with morphologic

More information

Corrigenda. WHO Classification of Tumours of Haematopoietic and Lymphoid Tissues (revised 4th edition): corrections made in second print run

Corrigenda. WHO Classification of Tumours of Haematopoietic and Lymphoid Tissues (revised 4th edition): corrections made in second print run Corrigenda WHO Classification of Tumours of Haematopoietic and Lymphoid Tissues (revised 4th edition): corrections made in second print run In addition to corrections of minor typographical errors, corrections

More information

Lymphoproliferative disorders

Lymphoproliferative disorders Lymphoproliferative disorders Objectives: To understand the general features of lymphoproliferative disorders (LPD) To understand some benign causes of LPD such as infectious mononucleosis To understand

More information

Clinical Policy: Bendamustine (Bendeka, Treanda) Reference Number: PA.CP.PHAR.307

Clinical Policy: Bendamustine (Bendeka, Treanda) Reference Number: PA.CP.PHAR.307 Clinical Policy: (Bendeka, Treanda) Reference Number: PA.CP.PHAR.307 Effective Date: 01/18 Last Review Date: 11/17 Coding Implications Revision Log Description The intent of the criteria is to ensure that

More information

Barbara Barnes Rogers, CRNP, MN, AOCN, ANP-BC Adult Hematology-Oncology Nurse Practitioner Fox Chase Cancer Center Philadelphia, Pennsylvania

Barbara Barnes Rogers, CRNP, MN, AOCN, ANP-BC Adult Hematology-Oncology Nurse Practitioner Fox Chase Cancer Center Philadelphia, Pennsylvania Barbara Barnes Rogers, CRNP, MN, AOCN, ANP-BC Adult Hematology-Oncology Nurse Practitioner Fox Chase Cancer Center Philadelphia, Pennsylvania Barbara.rogers@fccc.edu Disclosures Barbara Rogers, CRNP, MN,

More information

Non-Hodgkin s Lymphoma

Non-Hodgkin s Lymphoma Non-Hodgkin s Lympoma Non-Hodgkin s Lymphomas Janet H. Van Cleave MSN, ACNP-CS, CS, AOCN Acute Care Nurse Practitioner The Mount Sinai Medical Center of New York City Doctoral Student, Yale University

More information

MECHANISMS OF HUMAN DISEASE: LABORATORY SESSIONS LYMPHOMA. April 16, 2008

MECHANISMS OF HUMAN DISEASE: LABORATORY SESSIONS LYMPHOMA. April 16, 2008 MECHANISMS OF HUMAN DISEASE: LABORATORY SESSIONS LYMPHOMA April 16, 2008 FACULTY COPY GOAL: Learn the appearance of normal peripheral blood elements and lymph nodes. Recognize abnormal peripheral blood

More information

Q&A Session Collecting Cancer Data: Hematopoietic and Lymphoid Neoplasms Thursday, November 6, 2014

Q&A Session Collecting Cancer Data: Hematopoietic and Lymphoid Neoplasms Thursday, November 6, 2014 Q&A Session Collecting Cancer Data: Hematopoietic and Lymphoid Neoplasms Thursday, November 6, 2014 Q: If polycythemia ruba vera (PRV) or essential thrombocythemia (ET) is diagnosed by peripheral smear,

More information

Instructions for Chronic Lymphocytic Leukemia Post-HSCT Data (Form 2113)

Instructions for Chronic Lymphocytic Leukemia Post-HSCT Data (Form 2113) Instructions for Chronic Lymphocytic Leukemia Post-HSCT Data (Form 2113) This section of the CIBMTR Forms Instruction Manual is intended to be a resource for completing the CLL Post-HSCT Data Form. E-mail

More information

Corporate Medical Policy

Corporate Medical Policy Corporate Medical Policy Hematopoietic Stem-Cell Transplant for Non-Hodgkin Lymphomas File Name: Origination: Last CAP Review: Next CAP Review: Last Review: hematopoietic_stem-cell_transplant_for_non_hodgkin_lymphomas

More information

Aggressive Lymphomas - Current. Dr Kevin Imrie Physician-in-Chief, Sunnybrook Health Sciences Centre

Aggressive Lymphomas - Current. Dr Kevin Imrie Physician-in-Chief, Sunnybrook Health Sciences Centre Aggressive Lymphomas - Current Dr Kevin Imrie Physician-in-Chief, Sunnybrook Health Sciences Centre Conflicts of interest I have no conflicts of interest to declare Outline What does aggressive lymphoma

More information

Lymphoma Read with the experts

Lymphoma Read with the experts Lymphoma Read with the experts Marc Seltzer, MD Associate Professor of Radiology Geisel School of Medicine at Dartmouth Director, PET-CT Course American College of Radiology Learning Objectives Recognize

More information

155.2 Malignant neoplasm of liver not specified as primary or secondary. C22.9 Malignant neoplasm of liver, not specified as primary or secondary

155.2 Malignant neoplasm of liver not specified as primary or secondary. C22.9 Malignant neoplasm of liver, not specified as primary or secondary ICD-9 TO ICD-10 Reference ICD-9 150.9 Malignant neoplasm of esophagus unspecified site C15.9 Malignant neoplasm of esophagus, unspecified 151.9 Malignant neoplasm of stomach unspecified site C16.9 Malignant

More information

Hematology 101. Rachid Baz, M.D. 5/16/2014

Hematology 101. Rachid Baz, M.D. 5/16/2014 Hematology 101 Rachid Baz, M.D. 5/16/2014 Florida 101 Epidemiology Estimated prevalence 8,000 individuals in U.S (compare with 80,000 MM patients) Annual age adjusted incidence 3-8/million-year 1 More

More information

HEMATOPATHOLOGY. 2017/2018 2nd semester

HEMATOPATHOLOGY. 2017/2018 2nd semester HEMATOPATHOLOGY 2017/2018 2nd semester NORMAL HAEMOPOESIS COMMON MYELOID PRGENITOR HEMATOPOIETIC STEM CELL COMMON LYMPHOID PROGENITOR NK T B MEGAKARYO- BLAST PRONORMO- BLAST MONOBLAST MYELOBLAST PRO NK

More information

Leukemia And Lymphoma In The Nervous System

Leukemia And Lymphoma In The Nervous System Leukemia And Lymphoma In The Nervous System If you are searching for the book Leukemia and Lymphoma in the Nervous System in pdf format, then you've come to the right site. We presented complete variant

More information

Molecular Pathology of Lymphoma (Part 1) Rex K.H. Au-Yeung Department of Pathology, HKU

Molecular Pathology of Lymphoma (Part 1) Rex K.H. Au-Yeung Department of Pathology, HKU Molecular Pathology of Lymphoma (Part 1) Rex K.H. Au-Yeung Department of Pathology, HKU Lecture outline Time 10:00 11:00 11:15 12:10 12:20 13:15 Content Introduction to lymphoma Review of lymphocyte biology

More information

Elements for a Public Summary

Elements for a Public Summary VI.2 Elements for a Public Summary VI.2.1 Overview of disease epidemiology Chronic lymphocytic leukaemia 1 Chronic lymphocytic leukemia (CLL) is a condition characterized by a progressive accumulation

More information

NON HODGKINS LYMPHOMA: INDOLENT Updated June 2015 by Dr. Manna (PGY-5 Medical Oncology Resident, University of Calgary)

NON HODGKINS LYMPHOMA: INDOLENT Updated June 2015 by Dr. Manna (PGY-5 Medical Oncology Resident, University of Calgary) NON HODGKINS LYMPHOMA: INDOLENT Updated June 2015 by Dr. Manna (PGY-5 Medical Oncology Resident, University of Calgary) Reviewed by Dr. Michelle Geddes (Staff Hematologist, University of Calgary) and Dr.

More information

Roche s subcutaneous formulation of MabThera approved in Switzerland for the treatment of common types of non-hodgkin lymphoma

Roche s subcutaneous formulation of MabThera approved in Switzerland for the treatment of common types of non-hodgkin lymphoma Media Release Basel, 12 January 2017 Roche s subcutaneous formulation of MabThera approved in Switzerland for the treatment of common types of non-hodgkin lymphoma Administration time significantly reduced

More information

Normal Development. Normal Development 10/16/2012. Hematopoietic and Lymph Node Pathology. Red Blood Cell Maturation & Anemias

Normal Development. Normal Development 10/16/2012. Hematopoietic and Lymph Node Pathology. Red Blood Cell Maturation & Anemias Hematopoietic and Lymph Node Pathology Normal Development Red Blood Cell Maturation & Anemias Normal Development Differentiation of Hematopoietic Cells 1 Bone Marrow Bone Marrow Bone Marrow, RBC Precursors

More information

Recommended Timing for Transplant Consultation

Recommended Timing for Transplant Consultation REFERRAL GUIDELINES Recommended Timing for Transplant Consultation Published jointly by the National Marrow Donor Program /Be The Match and the American Society for Blood and Marrow Transplantation BeTheMatchClinical.org

More information

NAACCR Webinar Series 1

NAACCR Webinar Series 1 COLLECTING CANCER DATA: HEMATOPOIETIC AND LYMPHOID NEOPLASMS Jim Hofferkamp, CTR (jhofferkam@naaccr.org) Shannon Vann, CTR (svann@naaccr.org) Q&A Please submit all questions concerning webinar content

More information

Contents. vii. Preface... Acknowledgments... v xiii

Contents. vii. Preface... Acknowledgments... v xiii Contents Preface... Acknowledgments... v xiii SECTION I 1. Introduction... 3 Knowledge-Based Diagnosis... 4 Systematic Examination of the Lymph Node... 7 Cell Type Identification... 9 Cell Size and Cellularity...

More information

Prepared by: Dr.Mansour Al-Yazji

Prepared by: Dr.Mansour Al-Yazji C L L CLL Prepared by: Abd El-Hakeem Abd El-Rahman Abu Naser Ahmed Khamis Abu Warda Ahmed Mohammed Abu Ghaben Bassel Ziad Abu Warda Nedal Mostafa El-Nahhal Dr.Mansour Al-Yazji LEUKEMIA Leukemia is a form

More information

Chronic Lymphocytic Leukemia (CLL)

Chronic Lymphocytic Leukemia (CLL) Page 1 of 10 PATIENT EDUCATION Chronic Lymphocytic Leukemia (CLL) Introduction Chronic lymphocytic leukemia (CLL) is a type of cancer of the lymphocytes (a kind of white blood cell). It is also referred

More information

Recent diagnostic and therapeutic innovations of T-cell-lymphoma. Prof. Nossrat Firusian, Recklinghausen, Germany

Recent diagnostic and therapeutic innovations of T-cell-lymphoma. Prof. Nossrat Firusian, Recklinghausen, Germany Recent diagnostic and therapeutic innovations of T-cell-lymphoma Prof. Nossrat Firusian, Recklinghausen, Germany NODAL Angioimmunoblastic T-cell Lymphoma Peripheral T-cell-Lymphoma Anaplastic Large-cell-Lymphoma

More information

Done By : WESSEN ADNAN BUTHAINAH AL-MASAEED

Done By : WESSEN ADNAN BUTHAINAH AL-MASAEED Done By : WESSEN ADNAN BUTHAINAH AL-MASAEED Acute Myeloid Leukemia Firstly we ll start with this introduction then enter the title of the lecture, so be ready and let s begin by the name of Allah : We

More information

Retrospective data analysis of all requests for flow cytometric immunophenotyping in a tertiary hospital setting

Retrospective data analysis of all requests for flow cytometric immunophenotyping in a tertiary hospital setting Peer reviewed ORIGINAL ARTICLE Retrospective data analysis of all requests for flow cytometric immunophenotyping in a tertiary hospital setting A Prinsloo MSc J Nel MMed (Haem) R Pool MMed (Haem) Tshwane

More information

Primary Cutaneous CD30-Positive T-cell Lymphoproliferative Disorders

Primary Cutaneous CD30-Positive T-cell Lymphoproliferative Disorders Primary Cutaneous CD30-Positive T-cell Lymphoproliferative Disorders Definition A spectrum of related conditions originating from transformed or activated CD30-positive T-lymphocytes May coexist in individual

More information

Head and Neck: DLBCL

Head and Neck: DLBCL Head and Neck: DLBCL Nikhil G. Thaker Chelsea C. Pinnix Valerie K. Reed Bouthaina S. Dabaja Department of Radiation Oncology MD Anderson Cancer Center Case 60 yo male Presented with right cervical LAD

More information

Hematopathology Lab. Third year medical students

Hematopathology Lab. Third year medical students Hematopathology Lab Third year medical students Objectives Identify the lesion Know the specific name of the lesion Know associated disease Know relevant pathologic background Spherocytes: appear small,

More information

Lymphoma John P. Leonard, M.D.

Lymphoma John P. Leonard, M.D. Lymphoma 2017 John P. Leonard, M.D. Richard T. Silver Distinguished Professor of Hematology and Medical Oncology Associate Dean for Clinical Research Vice Chairman, Department of Medicine Disclosures Consulting

More information

Renal. Pathology. Kris%ne Kra*s, M.D.

Renal. Pathology. Kris%ne Kra*s, M.D. Renal Pathology Kris%ne Kra*s, M.D. Renal Pathology Outline Introductory stuff Glomerular diseases Tubular and inters%%al diseases Diseases involving blood vessels Cys%c diseases Tumors Renal Pathology

More information

DETERMINATION OF A LYMPHOID PROCESS

DETERMINATION OF A LYMPHOID PROCESS Chapter 2 Applications of Touch Preparation Cytology to Intraoperative Consultations: Lymph Nodes and Extranodal Tissues for Evaluation of Hematolymphoid Disorders INTRODUCTION As discussed in Chap. 1,

More information