UP-REGULATION OF MIRNA-222 PREDICTS POOR PROGNOSIS AND TUMOR PROGRESSION IN
|
|
- Alexis Ryan
- 6 years ago
- Views:
Transcription
1 Acta Medica Mediterranea, 2017, 33: 231 UP-REGULATION OF MIRNA-222 PREDICTS POOR PROGNOSIS AND TUMOR PROGRESSION IN PATIENTS WITH ADVANCED STAGE NON-SMALL CELL LUNG CANCER YI-MING XU 1,*, WEI LIU 2,*, LI-HUA YAN, SHENG-GUANG DING, HAI-TAO HUANG, CHONG-JUN ZHONG 1 Department of Thoracic and Cardiovascular Surgery, The Affiliated Hospital of Nantong University, Nantong , China - 2 Department of Thoracic Surgery, Haian people s Hospital Affiliated to Nantong University, Nantong , China *These authors contributed equally to this work. ABSTRACT MicroRNAs (mirnas) are endogenous small noncoding RNAs that play important roles in regulating cancers. We previously indicated that mir-222 promotes non-small cell lung cancer growth. Here, we aimed to investigate whether the mir-222 expression level was associated with clinic pathological factors and prognostic values of non-small cell lung cancer (NSCLC). The expression level of mir-222 in the pathological tissues and paired normal tissues of NSCLC was evaluated using a quantitative real-time RT-PCR. A Kaplan-Meier survival curve was demonstrated following a log-rank test. Results showed that mir-222 expression level is up-regulated in NSCLC tissues compared with matched normal tissues (mean ± SD: 3.55 ± 1.71vs ± 1.01, P < 0.001). The high expression of mir-222 in NSCLC cancer tissues was also remarkably related with aggressive clinic pathological features. The expression level of mir-222 was associated with tumor grade (P=0.031) and lymph node metastasis (P = ). Moreover, the results of Kaplan-Meier analyses indicated that patients with high expression level of microrna-222 had shorter overall survival and progression free survival (P < 0.001). The multivariate analysis clearly indicated that the high mir-222 expression in biopsy samples might be a useful independent biomarker for NSCLC prognosis (RR 3.23; 95%CI, ). Our data demonstrated that the aberrant expression of microrna-222 is associated with NSCLC progression and it might be a potential biomarker for NSCLC prognosis. Keywords: microrna-222, non-small cell lung cancer, progression and prognosis. DOI: / _2017_2_034 Received October 30, 2016; Accepted January 02, 2017 Introduction Lung cancer is the leading cause of cancerrelated mortality worldwide and annually responsible for more than 500,000 deaths worldwide (1). Approximately 80% of the lung cancer patients have non-small cell lung cancer (NSCLC). Once diagnosed, survival rates are low. Even diagnosed early, grade I lung cancer patients have only a 60-70% five-year survival rate (2-4). Although interventions have been improved in recent years, the prognosis and long-term survival of the NSCLC patients are still poor (5). Thus, there is a need to identify novel, noninvasive prognostic biomarkers for NSCLC in order to improve diagnostic and therapeutic strategies. MicroRNAs (mirnas) are an abundant class of nucleotides small non-coding RNAs and would post-transcriptionally regulate gene expression through directly binding to the 3 untranslational region (3 UTR) of target mrnas (6). Through the post-transcriptional path, mirnas have been shown to play fundamental roles in diverse biological and pathological processes, including cell pro-
2 232 Yi-Ming Xu, Wei Liu et Al liferation, differentiation, apoptosis, and carcinogenesis (7-9). Moreover, many studies have shown that mirnas exhibit altered expression in various cancers and may serve as important prognostic biomarker of cancers (10). MiR-222 belongs to the mir-221/222 family, and has been reported to play a potential oncogenic role in multiple cancer types including hepatocellular carcinoma, breast cancer, prostate cancer, bladder cancer, endometrial carcinoma and glioblastoma (11-17). We previously reported that mir-221/222 promoted the growth of human NSCLC cell line H460 (18-19). MiR-222 was reported to be a prognostic factor for hepatocellular carcinoma, papillary thyroid carcinoma, glioblastoma, gastric carcinoma, pancreatic cancer et al (20-25). Here, we studied the mir-222 expression in NSCLC to evaluate their value in prognosis and progression. We examined the up-regulation of mir-222 in 178 NSCLC cases by means of quantitative real-time reverse-transcription PCR (RT- PCR). We found that mir-222 is overexpressed in NSCLC. More importantly, those patients with increased mir222 expressions were also found to have worse prognosis and this prognostic impact appears to be independent of other factors in multivariate Cox regression analysis Table 2. Materials and methods Ethics Statement The Research Ethics Committee of the Second Affiliated Hospital of Nantong University approved the study. All participants were informed about the purpose, procedures, and potential risks and benefits of the study, and their written informed consent were obtained. Patient tissue samples and clinical information collection 178 patients with NSCLC confirmed by pathological and clinical diagnoses in the Second Affiliated Hospital of Nantong University were enrolled in this study from January 2006 to January None of the patients had received chemotherapy or radiotherapy before surgery. The collected pathological tissues and matched normal tissues of the enrolled patients were put in liquid nitrogen immediately and stored at -80 C before use. RNA extraction The total RNA of the pathological tissues and corresponding normal tissues were extracted using TRIZOL reagent (Invitrogen, USA) following the manufacturer s instructions. Reverse transcription reaction was performed using Bulge-Loop mirna qrt-pcr Primer Set (Ribobio, China) according to the manufacturer s protocols. Then cdna was subjected into 40 cycles of quantitative PCR with Takara SYBR Premix Ex TaqTM (Takara, Japan) in CFX96TM Real-Time PCR Detection System (Bio-Rad, USA), using the following cycling conditions: 95 C for 10 min; 95 C for 10 s, 60 C for 20 s, 72 C for 10 s, 40 cycles. The U6 small nuclear (sn) RNA was used to normalize mir-222. Statistical analyses To analyze clinic pathologic characteristics, Chi-square tests were used for the categorical data and Mann-Whitney tests for continuous data when comparing patient and control data. Differences in mirna-222 expression levels between NSCLC and matched normal tissues were compared using an Independent sample Student s t-test. Associations between mir-222 levels and over survival of the patients with NSCLC were estimated using adjusted relative risks and 95% confidence intervals (95 % CIs) from multivariate logistic regression. Survival time was calculated from the date of NSCLC diagnosis to the date of death or last follow-up. Survival analysis was estimated using the Kaplan-Meier method, log-rank test, and Cox-proportional hazards regression model. P < 0.05 indicated significant difference. The Statistical Product and Service Solutions (SPSS) software version 20.0 for Windows was used for statistical analysis and Figures were constructed using Graph Pad Prism 5.0 (La Jolla, CA, USA). Results Relative expression of mir-222 in patients with NSCLC 178 patients were recruited in this study. The clinical information of the NSCLC patients was summarized in Table 1. The median age of the NSCLC patients at diagnosis was 52.8 year (range, year). QRT-PCR was used to detect the relative expression of microrna-222 in the pathological tissues and corresponding normal tissues of the NSCLC patients. The relative expression level in pathological tissues was 3.55 ± 1.71 while the corresponding in normal tissues was 2.08 ± 1.01.
3 Up-regulation of mirna-222 predicts poor prognosis and tumor progression in patients with advanced There was a significant difference between them (P < 0.001, Fig. 1). In addition, there was also a significant difference in mir-21 expression between high-grade (IIb-IIIa) and low-grade (Ia-IIa) NSCLC tissue specimens (P < 0.001, Fig. 1). Table 1: Association of mir-222 expression with clinicpathological characteristics of non-small cell lung cancer (n = 178). Fig. 1: MiR-222 expression in 178 pairs of NSCLC and adjacent nonneoplatic lung tissues confirmed by quantitative real-time polymerase chain reaction (qrt-pcr) analysis according to different tumor grades (normal, all cancer and grade Ia-IIIa). The relation between mir-222 expression and clinical features To analyze the association between mir-222 expression and clinic pathological parameters, the NSCLC patients were divided into two groups, according to their average expression level. The results of the Chi-square method suggested that the high level of mir-222 expression was significantly more common in NSCLC tissues with advanced pathologic grade than those with low pathologic grade (P < 0.031, Table 1). Besides, the expression level of mir-222 was associated with the lymph node metastasis (P = ). Meanwhile, it was not relevant to the age, gender, smoking history, tumor size and histology (P > 0.05). The relationship between mir-222 expression and survival of NSCLC patients Kaplan-Meier method was used for survival analysis. The patients with high expression level of mir-222 had shorter overall survival (P < 0.001, Fig. 2a). However, when the pathological grades were considered, the higher mir-222 expression was a risk of poor prognosis in both the high grade NSCLC (IIb-IIIa, P < 0.001, Fig. 2b) and the low grade NSCLC (Ia-IIa, P < 0.001, Fig. 2c). To further evaluate whether mir-222 levels can predict NSCLC prognosis, we valued the progression-free survival, which proved shorter in patients with high mir-222 expression (P < 0.001, Fig. 3a). The higher mir-222 expression was a risk of shorter progression-free survival in both the high grade NSCLC (IIb-IIIa, P = , Fig. 3b) and the low grade NSCLC (Ia-IIa, P < 0.001, Fig. 3c). Multivariate cox proportional Hazard analysis Multivariate Cox regression analysis was performed to estimate the prognostic value of mir-222 in NSCLC patients and the results were shown in Table 2. From the table, we found that the expression level of mir-222 was associated with the prognosis in biopsy samples (RR, 3.23, 95% CI, , P < 0.001), tumor grade (RR 2.19; 95% CI, , P = 0.019) and lymph node metastasis (RR, 2.87; 95% CI, , P = 0.004) and it could act as an independent biomarker for prognosis of NSCLC patients. Discussion Although with the development of diagnosis and surgical techniques, the patients with NSCLC still demonstrated a poor prognosis. Therefore, identification of novel molecular biomarkers associated with the prognosis of patients with NSCLC was urgently needed now. mirnas have been indicated to be critical regulators of carcinogenesis and tumor progression in NSCLC.
4 234 Yi-Ming Xu, Wei Liu et Al Fig. 2: Kaplan-Meier survival curves for NSCLC patients with high or low expression of mir-222. A. The 5-year overall survival rate of all 178 NSCLC patients with high or low mir-222 expression; B. The 5-year overall survival rate of 124 NSCLC patients with low pathological grades (tumor grade Ia ~ IIa) in high or low mir-222 expression group; C. The 5-year overall survival rate of 54 NSCLC patients with advanced pathological grades (tumor grade IIb ~ IIIa) in high or low mir-222 expression group. Fig. 3: Kaplan-Meier progression free survival curves for NSCLC patients with high or low expression of mir-21. A. The overall progression free survival rate of 178 NSCLC patients with high or low mir-222 expression; B. The progression free survival rate of 124 NSCLC patients with low pathological grades (tumor grade Ia ~ IIa) in high or low mir-222 expression group; C. The progression free survival rate of 54 NSCLC patients with advanced pathological grades (tumor grade IIb ~ IIIa) in high or low mir-222 expression group. Table 2: Multivariate analyses of different prognostic parameters in patients with non-small cell lung cancer by Cox regression analysis. In 2011, Zhang et al. found that mir-222 was up-regulated in NSCLC patients (26). We further indicated that mir-222 promotes human non-small cell lung cancer growth via targeting p27 (19). However, the clinical significance of mir-222 expression in this tumor remains unclear. In this study, we showed that mir-222 expression was up-regulated in NSCLC tissues compared with matched no cancerous lung tissues. The overexpression of mir-222 in NSCLC tissues was also significantly related with aggressive clinic pathological features. Besides, patients with high mir-222 have higher tumor grade and are in higher risk of lymph node metastasis. Moreover, the results of Kaplan-Meier analyses showed that NSCLC patients with the high mir-222 expression incline to have shorter overall survival and progression free survival. The multivariate analysis indicated that the increased mir- 222 expression in biopsy samples might act as an independent prognostic parameter in NSCLC for reduced survival. mirnas play important roles in regulating kinds of cancers. The regulation includes activation of oncogenes and inactivation of tumor suppressor genes. Among them mirnas are reported to locate in the cancer-associated genomic region or in fragile sites (27). So they could act as gene regulators of metastasis by taking part in different signaling pathways (28). Such as mir-126, mr-195 and let-7c were reported to be associated with cancers (29-31). For the up-regulated mir-222, its potential target genes include the tumor suppressor gene p27, p57, PTEN and et al. Zhang et al. found that the expression of high mobility group A1 (HMGA1) was in positive correlation with mir-222 in NSCLC samples (26). In 2013, Wang et al. found that metformin inhibited lung cancer cells proliferation through repressing mir-222 (32).
5 Up-regulation of mirna-222 predicts poor prognosis and tumor progression in patients with advanced Up-regulation of mir-222 has been indicated in several types of cancers, suggesting its important role in occurrence and development of cancers. Moreover, previous studies have verified the prognostic value of mir-222 and as non-invasive biomarkers. Zhang et al showed that high level of mir-222 confers increased cell invasion and poor prognosis in glioma (22). Kim et al found that mir- 222 is up-regulated in advanced gastric carcinoma (23). Lee et al indicated that mir-222 is associated with poor prognosis in pancreatic cancer. In addition, mir-222 was also reported to be a prognostic factor for hepatocellular carcinoma, papillary thyroid carcinoma et al (20, 21). In line with these studies, we confirmed that the expression levels of mir-222 in NSCLC tissues were significantly higher than those in normal adjacent tissue, and increased mir- 222 expression was independently associated with poor survival and tumor progression. In conclusion, the results have demonstrated that the levels of mir-222 are higher in NSCLC tissues than those in matched normal tissues and correlated with tumor grade and lymph node metastasis. Our findings promote better understanding of the role of mir-222 in NSCLC progression and suggest that mir-222 may function as tumor promoter genes in patient with NSCLC. These results make the potential clinical value of microrna measurements clear, particularly in evaluating prognosis for NSCLC patients. Large well-designed studies with diverse populations and functional evaluations are warranted to confirm and extend our findings. MiR-222, a potential prognostic biomarker, may be a novel therapy target for patients with NSCLC in future. References 1) Mellema WW, Burgers SA and Smit EF. Tumor flare after start of RAF inhibition in KRAS mutated: a case report. Lung Cancer 2015; 87: ) Hata A, Katakami N, Yoshioka H, Takeshita J, Tanaka K, Nanjo S, Fujita S, et al. Rebiopsy of non-small cell lung cancer patients with acquired resistance to epidermal growth factor receptor tyrosine kinase inhibitor: comparison between T790M mutation positive and mutation-ne gative populations. Cancer 2013; 119: 4325-MJNL ) Spigel DR, Ervin TJ, Ramlau RA, Daniel DB, Goldschmidt Jr JH, Blumenschein Jr GR, Krzakowski NSCLC MJ, et al. Randomized phase II trial of onartuzumab in combination with erlotinib in patients with advanced Non-small-cell lung cancer. J Clin Oncol 2013; 31: ) Shapiro M, Kadakia S, Lim J, Breglio A, Wisnivesky JP, Kaufman A, Lee DS, et al. Lobe-specific mediastinal nodal dissection is sufficient during lobectomy by video-assisted thoracic surgery or thoracotomy for early-stage lung cancer. Chest 2013; 144: ) Ke Z, He W, Lai Y, Guo X, Chen S, Li S, et al. Overexpression of collagen triple helix repeat containing 1 (CTHRC1) is associated with tumour aggressiveness and poor prognosis in human non-small cell lung cancer. Oncotarget 2014; 5(19): ) Sandhu R, Rivenbark AG, Mackler RM, Livasy CA and Coleman WB. Dysregulation of microrna expression drives aberrant DNA hypermethylation in basal-like breast cancer. Int J Oncol 2014; 44: ) Esquela-Kerscher A, Slack FJ () Oncomirs - micrornas with a role in cancer. Nat Rev Cancer 2006; 6: ) De Yebenes VG, Ramiro AR MicroRNA activity in B lymphocytes. Methods Mol Biol 2010; 667: ) Pasquinelli AE, Reinhart BJ, Slack F, Martindale MQ, Kuroda MI, Maller B, Hayward DC, et al. Conservation of the sequence and temporal expression of let-7 heterochronic regulatory RNA. Nature 2000; 408: ) Tafsiri E, Darbouy M, Shadmehr MB, Zagryazhskaya A, Alizadeh J, Karimipoor M. Expression of mirnas in non-small-cell lung carcinomas and their association with clinicopathological features. Tumor Biology 2015; 36(3): ) Bandopadhyay M, Banerjee A, Sarkar N, Panigrahi R, Datta S, Pal A, Singh SP, Biswas A, Chakrabarti S and Chakravarty R. Tumor suppressor micro RNA mir-145 and onco micro RNAs mir-21 and mir-222 expressions are differentially modulated by hepatitis B virus X protein in malignant hepatocytes. BMC Cancer 2014; 14: ) Gan R, Yang Y, Yang X, Zhao L, Lu J and Meng QH. Down-regulation of mir-221/222 enhances sensitivity of breast cancer cells to tamoxifen through upregulation of TIMP3. Cancer Gene Ther 2014; 21: ) Liu M, Liu J, Wang L, Wu H, Zhou C, Zhu H, Xu N and Xie Y. Association of serum microrna expression in hepatocellular carcinomas treated with transarterial chemoembolization and patient survival. PLoS One 2014; 9: e ) Li Y, Liang C, Ma H, Zhao Q, Lu Y, Xiang Z, Li L, Qin J, Chen Y, Cho WC, Pestell RG, Liang L and Yu Z. mir-221/222 promotes S-phase entry and cellular migration in control of basal-like breast cancer. Molecules 2014; 19: ) Liu B, Che Q, Qiu H, Bao W, Chen X, Lu W, Li B and Wan X. Elevated MiR-222-3p promotes proliferation and invasion of endometrial carcinoma via targeting ERalpha. PLoS One 2014; 9: e ) Yang X, Yang Y, Gan R, Zhao L, Li W, Zhou H, Wang X, Lu J and Meng QH. Down-regulation of mir-221 and mir-222 restrain prostate cancer cell proliferation and migration that is partly mediated by activation of SIRT1. PLoS One 2014; 9: e ) Yang YF, Wang F, Xiao JJ, Song Y, Zhao YY, Cao Y, Bei YH and Yang CQ. MiR-222 overexpression promotes proliferation of human hepatocellular carcinoma HePG2 cells by downregulating p27. Int J Clin Exp Med 2014; 7:
6 236 Yi-Ming Xu, Wei Liu et Al 18) Xu YM, Zhong CJ, Ding SG, Huang HT and Shen ZY. MicroRNA-221 promotes human non-small cell lung cancer cell H460 growth. Int J Clin Exp Med 2015; 8: ) Zhong CJ, Ding SG, Xu YM, Huang HT MicroRNA- 222 promotes human non-small cell lung cancer cell H460 growth by targeting p27. Int J Clin Exp Med 2015; 8(4): ) Karakatsanis A, Papaconstantinou I, Gazouli M, Lyberopoulou A, Polymeneas G, Voros D.Expression of micrornas, mir-21, mir-31, mir-122, mir-145, mir-146a, mir-200c, mir-221, mir-222, and mir-223 in patients with hepatocellular carcinoma or intrahepatic cholangiocarcinoma and its prognostic significance. Mol Carcinog 2013; 52(4): ) Yip L, Kelly L, Shuai Y, Armstrong MJ, Nikiforov YE, Carty SE, Nikiforova MN. MicroRNA signature distinguishes the degree of aggressiveness of papillary thyroid carcinoma. Ann Surg Oncol 2011; 18(7): ) Zhang C, Zhang J, Hao J, Shi Z, Wang Y, Han L, Yu S, You Y, Jiang T, Wang J, Liu M, Pu P, Kang C. High level of mir-221/222 confers increased cell invasion and poor prognosis in glioma. J Transl Med 2012; 8; 10: ) Kim BH, Hong SW, Kim A, Choi SH, Yoon SO. Prognostic implications for high expression of oncogenic micrornas in advanced gastric carcinoma. J Surg Oncol 2013; 107(5): ) Lee C, He H, Jiang Y, Di Y, Yang F, Li J, Jin C, Fu D. Elevated expression of tumor mir-222 in pancreatic cancer is associated with Ki67 and poor prognosis. Med Oncol 2013; 30(4): ) Zhang DQ, Zhou CK, Jiang XW, Chen J, Shi BK. Increased expression of mir-222 is associated with poor prognosis in bladder cancer. World J Surg Oncol 2014; 31: 12: ) Y. Zhang, T. Ma, S. Yang et al., High-mobility group A1 proteins enhance the expression of the oncogenic mir-222 in lung cancer cells. Molecular and Cellular Biochemistry 2011; 357: 1-2: ) Brighenti M. MicroRNA and MET in lung cancer. Ann Transl Med 2015; 3(5):68. 28) Nicoloso MS, Spizzo R, Shimizu M, Rossi S, Calin GA. MicroRNAs-the micro steering wheel of tumor metastases. Nat Rev Cancer 2009; 9(4): ) Li Z, Li N, Wu M, Li X, Luo Z, Wang X. Expression of mir-126 suppresses migration and invasion of colon cancer cells by targeting CXCR4. Mol Cell Biochem 2013; 381: ) Jia LF, Wei SB, Gong K, Gan YH, Yu GY. Prognostic implications of mir-195 expression in human tongue squamous cell carcinoma. PLoS One 2013; 8:e ) Pelosi A, Careccia S, Lulli V, Romania P, Marziali G, Testa U, Lavorgna S, et al. MiRNA let-7c promotes granulocytic differentiation in acute myeloid leukemia. Oncogene 2013; 32: ) Y. Wang, W. Dai, X. Chu, B. Yang, M. Zhao, and Y. Sun. Metformin inhibits lung cancer cells proliferation through repressing MicroRNA-222. Biotechnology Letters 2013; 35: Acknowledgements Thanks Doctor Liang Shen (The Department of Thoracic and Cardiovascular Surgery, The Second Affiliated Hospital of Nantong University) for clinical tissue samples and information collection. This work was supported by the grants from Science and Technology Support Program of Nantong City (No.MS ). Corresponding author Dr. CHONGJUN ZHONG Department of Thoracic and Cardiovascular Surgery, The Second Affiliated Hospital of Nantong University, No 6 Haierxiang Bei Road Nantong (China)
CircHIPK3 is upregulated and predicts a poor prognosis in epithelial ovarian cancer
European Review for Medical and Pharmacological Sciences 2018; 22: 3713-3718 CircHIPK3 is upregulated and predicts a poor prognosis in epithelial ovarian cancer N. LIU 1, J. ZHANG 1, L.-Y. ZHANG 1, L.
More informationMir-595 is a significant indicator of poor patient prognosis in epithelial ovarian cancer
European Review for Medical and Pharmacological Sciences 2017; 21: 4278-4282 Mir-595 is a significant indicator of poor patient prognosis in epithelial ovarian cancer Q.-H. ZHOU 1, Y.-M. ZHAO 2, L.-L.
More informationOriginal Article Up-regulation of mir-10a and down-regulation of mir-148b serve as potential prognostic biomarkers for osteosarcoma
Int J Clin Exp Pathol 2016;9(1):186-190 www.ijcep.com /ISSN:1936-2625/IJCEP0018032 Original Article Up-regulation of mir-10a and down-regulation of mir-148b serve as potential prognostic biomarkers for
More informationDecreased expression of mir-490-3p in osteosarcoma and its clinical significance
European Review for Medical and Pharmacological Sciences Decreased expression of mir-490-3p in osteosarcoma and its clinical significance B. TANG, C. LIU, Q.-M. ZHANG, M. NI Department of Orthopedics,
More informationOriginal Article Tissue expression level of lncrna UCA1 is a prognostic biomarker for colorectal cancer
Int J Clin Exp Pathol 2016;9(4):4241-4246 www.ijcep.com /ISSN:1936-2625/IJCEP0012296 Original Article Tissue expression level of lncrna UCA1 is a prognostic biomarker for colorectal cancer Hong Jiang,
More informationReduced mirna-218 expression in pancreatic cancer patients as a predictor of poor prognosis
Reduced mirna-218 expression in pancreatic cancer patients as a predictor of poor prognosis B.-S. Li, H. Liu and W.-L. Yang Department of Gastrointestinal and Pancreatic Surgery, The Third Xiangya Hospital
More informationLow levels of serum mir-99a is a predictor of poor prognosis in breast cancer
Low levels of serum mir-99a is a predictor of poor prognosis in breast cancer J. Li 1, Z.J. Song 2, Y.Y. Wang 1, Y. Yin 1, Y. Liu 1 and X. Nan 1 1 Tumor Research Department, Shaanxi Provincial Tumor Hospital,
More informationCircular RNA_LARP4 is lower expressed and serves as a potential biomarker of ovarian cancer prognosis
European Review for Medical and Pharmacological Sciences 2018; 22: 7178-7182 Circular RNA_LARP4 is lower expressed and serves as a potential biomarker of ovarian cancer prognosis T. ZOU, P.-L. WANG, Y.
More informationOverexpression of long-noncoding RNA ZFAS1 decreases survival in human NSCLC patients
European Review for Medical and Pharmacological Sciences 2016; 20: 5126-5131 Overexpression of long-noncoding RNA ZFAS1 decreases survival in human NSCLC patients F.-M. TIAN 1, F.-Q. MENG 2, X.-B. WANG
More informationExpression of mir-1294 is downregulated and predicts a poor prognosis in gastric cancer
European Review for Medical and Pharmacological Sciences 2018; 22: 5525-5530 Expression of mir-1294 is downregulated and predicts a poor prognosis in gastric cancer Y.-X. SHI, B.-L. YE, B.-R. HU, X.-J.
More informationmir-218 tissue expression level is associated with aggressive progression of gastric cancer
mir-218 tissue expression level is associated with aggressive progression of gastric cancer X.X. Wang 1, S.J. Ge 2, X.L. Wang 2, L.X. Jiang 1, M.F. Sheng 2 and J.J. Ma 2 1 Department of General Surgery,
More informationExpression of long non-coding RNA linc-itgb1 in breast cancer and its influence on prognosis and survival
European Review for Medical and Pharmacological Sciences 2017; 21: 3397-3401 Expression of long non-coding RNA linc-itgb1 in breast cancer and its influence on prognosis and survival W.-X. LI 1, R.-L.
More informationAssociation of mir-21 with esophageal cancer prognosis: a meta-analysis
Association of mir-21 with esophageal cancer prognosis: a meta-analysis S.-W. Wen 1, Y.-F. Zhang 1, Y. Li 1, Z.-X. Liu 2, H.-L. Lv 1, Z.-H. Li 1, Y.-Z. Xu 1, Y.-G. Zhu 1 and Z.-Q. Tian 1 1 Department of
More informationExpression of lncrna TCONS_ in hepatocellular carcinoma and its influence on prognosis and survival
European Review for Medical and Pharmacological Sciences 2017; 21: 5655-5660 Expression of lncrna TCONS_00027978 in hepatocellular carcinoma and its influence on prognosis and survival Q. CHEN 1, G.-D.
More informationLong non-coding RNA Loc is a potential prognostic biomarker in non-small cell lung cancer
European Review for Medical and Pharmacological Sciences 2017; 21: 3808-3812 Long non-coding RNA Loc344887 is a potential prognostic biomarker in non-small cell lung cancer B. WU 1, X.-J. ZHANG 2, X.-G.
More informationOriginal Article CREPT expression correlates with esophageal squamous cell carcinoma histological grade and clinical outcome
Int J Clin Exp Pathol 2017;10(2):2030-2035 www.ijcep.com /ISSN:1936-2625/IJCEP0009456 Original Article CREPT expression correlates with esophageal squamous cell carcinoma histological grade and clinical
More informationOriginal Article High serum mir-203 predicts the poor prognosis in patients with pancreatic cancer
Int J Clin Exp Pathol 2017;10(4):4688-4693 www.ijcep.com /ISSN:1936-2625/IJCEP0047128 Original Article High serum mir-203 predicts the poor prognosis in patients with pancreatic cancer Jun Ma, Xiaokun
More informationTitle:Identification of a novel microrna signature associated with intrahepatic cholangiocarcinoma (ICC) patient prognosis
Author's response to reviews Title:Identification of a novel microrna signature associated with intrahepatic cholangiocarcinoma (ICC) patient prognosis Authors: Mei-Yin Zhang (zhangmy@sysucc.org.cn) Shu-Hong
More informationDownregulation of serum mir-17 and mir-106b levels in gastric cancer and benign gastric diseases
Brief Communication Downregulation of serum mir-17 and mir-106b levels in gastric cancer and benign gastric diseases Qinghai Zeng 1 *, Cuihong Jin 2 *, Wenhang Chen 2, Fang Xia 3, Qi Wang 3, Fan Fan 4,
More informationAnalysis of circulating long non-coding RNA UCA1 as potential biomarkers for diagnosis and prognosis of osteosarcoma
European Review for Medical and Pharmacological Sciences 2017; 21: 498-503 Analysis of circulating long non-coding RNA UCA1 as potential biomarkers for diagnosis and prognosis of osteosarcoma J.-J. WEN
More informationAssociation between downexpression of mir-1301 and poor prognosis in patients with glioma
European Review for Medical and Pharmacological Sciences 2017; 21: 4298-4303 Association between downexpression of mir-1301 and poor prognosis in patients with glioma Q.-L. BAI, C.-W. HU, X.-R. WANG, G.-F.
More informationClinical impact of serum mir-661 in diagnosis and prognosis of non-small cell lung cancer
European Review for Medical and Pharmacological Sciences 2017; 21: 5696-5701 Clinical impact of serum mir-661 in diagnosis and prognosis of non-small cell lung cancer G.-H. ZHOU 1, W.-H. YANG 2, B. SUN
More informationExpression of mir-146a-5p in patients with intracranial aneurysms and its association with prognosis
European Review for Medical and Pharmacological Sciences 2018; 22: 726-730 Expression of mir-146a-5p in patients with intracranial aneurysms and its association with prognosis H.-L. ZHANG 1, L. LI 2, C.-J.
More information95% CI: , P=0.037).
Biomedical Research 2017; 28 (21): 9248-9252 Reduced expression level of mir-205 predicts poor prognosis in Qiang Yang 1*#, Peng Sun 2#, Haotian Feng 1, Xin Li 1, Jianmin Li 1 1 Department of Orthopedics,
More informationLong noncoding RNA CASC2 inhibits metastasis and epithelial to mesenchymal transition of lung adenocarcinoma via suppressing SOX4
European Review for Medical and Pharmacological Sciences 2017; 21: 4584-4590 Long noncoding RNA CASC2 inhibits metastasis and epithelial to mesenchymal transition of lung adenocarcinoma via suppressing
More informationOriginal Article Reduced expression of mir-506 in glioma is associated with advanced tumor progression and unfavorable prognosis
Int J Clin Exp Pathol 2016;9(1):181-185 www.ijcep.com /ISSN:1936-2625/IJCEP0017823 Original Article Reduced expression of mir-506 in glioma is associated with advanced tumor progression and unfavorable
More informationClinical significance of up-regulated lncrna NEAT1 in prognosis of ovarian cancer
European Review for Medical and Pharmacological Sciences 2016; 20: 3373-3377 Clinical significance of up-regulated lncrna NEAT1 in prognosis of ovarian cancer Z.-J. CHEN, Z. ZHANG, B.-B. XIE, H.-Y. ZHANG
More informationCorrelation between estrogen receptor β expression and the curative effect of endocrine therapy in breast cancer patients
1568 Correlation between estrogen receptor β expression and the curative effect of endocrine therapy in breast cancer patients LIYING GUO 1, YU ZHANG 2, WEI ZHANG 3 and DILIMINA YILAMU 1 1 Department of
More informationMicroRNA expression profiling and functional analysis in prostate cancer. Marco Folini s.c. Ricerca Traslazionale DOSL
MicroRNA expression profiling and functional analysis in prostate cancer Marco Folini s.c. Ricerca Traslazionale DOSL What are micrornas? For almost three decades, the alteration of protein-coding genes
More informationPrognostic significance of overexpressed long non-coding RNA TUG1 in patients with clear cell renal cell carcinoma
European Review for Medical and Pharmacological Sciences 2017; 21: 82-86 Prognostic significance of overexpressed long non-coding RNA TUG1 in patients with clear cell renal cell carcinoma P.-Q. WANG, Y.-X.
More informationProfiles of gene expression & diagnosis/prognosis of cancer. MCs in Advanced Genetics Ainoa Planas Riverola
Profiles of gene expression & diagnosis/prognosis of cancer MCs in Advanced Genetics Ainoa Planas Riverola Gene expression profiles Gene expression profiling Used in molecular biology, it measures the
More informationLong noncoding RNA linc-ubc1 promotes tumor invasion and metastasis by regulating EZH2 and repressing E-cadherin in esophageal squamous cell carcinoma
JBUON 2018; 23(1): 157-162 ISSN: 1107-0625, online ISSN: 2241-6293 www.jbuon.com E-mail: editorial_office@jbuon.com ORIGINAL ARTICLE Long noncoding RNA linc-ubc1 promotes tumor invasion and metastasis
More informationDown-regulation of long non-coding RNA MEG3 serves as an unfavorable risk factor for survival of patients with breast cancer
European Review for Medical and Pharmacological Sciences 2016; 20: 5143-5147 Down-regulation of long non-coding RNA MEG3 serves as an unfavorable risk factor for survival of patients with breast cancer
More informationClinicopathologic and prognostic relevance of mir-1256 in colorectal cancer: a preliminary clinical study
European Review for Medical and Pharmacological Sciences 2018; 22: 7704-7709 Clinicopathologic and prognostic relevance of mir-1256 in colorectal cancer: a preliminary clinical study Z.-Y. LIU, L. YANG,
More informationLong non-coding RNA TUSC7 expression is independently predictive of outcome in glioma
European Review for Medical and Pharmacological Sciences 2017; 21: 3605-3610 Long non-coding RNA TUSC7 expression is independently predictive of outcome in glioma X.-L. MA 1, W.-D. ZHU 2, L.-X. TIAN 2,
More informationLong noncoding RNA LINC01510 is highly expressed in colorectal cancer and predicts favorable prognosis
European Review for Medical and Pharmacological Sciences 2018; 22: 7710-7715 Long noncoding RNA LINC01510 is highly expressed in colorectal cancer and predicts favorable prognosis J.-F. ZHOU, H.-G. WANG,
More informationOriginal Article Reduced serum mir-138 is associated with poor prognosis of head and neck squamous cell carcinoma
Int J Clin Exp Pathol 2017;10(10):10276-10281 www.ijcep.com /ISSN:1936-2625/IJCEP0059849 Original Article Reduced serum mir-138 is associated with poor prognosis of head and neck squamous cell carcinoma
More informationLong non-coding RNA CCHE1 overexpression predicts a poor prognosis for cervical cancer
European Review for Medical and Pharmacological Sciences 2017; 20: 479-483 Long non-coding RNA CCHE1 overexpression predicts a poor prognosis for cervical cancer Y. CHEN, C.-X. WANG, X.-X. SUN, C. WANG,
More informationUp-regulation of long non-coding RNA SNHG6 predicts poor prognosis in renal cell carcinoma
European Review for Medical and Pharmacological Sciences 2018; 22: 8624-8629 Up-regulation of long non-coding RNA SNHG6 predicts poor prognosis in renal cell carcinoma H.-X. AN 1, B. XU 2, Q. WANG 3, Y.-S.
More informationDownregulation of long non-coding RNA LINC01133 is predictive of poor prognosis in colorectal cancer patients
European Review for Medical and Pharmacological Sciences 2017; 21: 2103-2107 Downregulation of long non-coding RNA LINC01133 is predictive of poor prognosis in colorectal cancer patients J.-H. ZHANG 1,
More informationHigh expression of fibroblast activation protein is an adverse prognosticator in gastric cancer.
Biomedical Research 2017; 28 (18): 7779-7783 ISSN 0970-938X www.biomedres.info High expression of fibroblast activation protein is an adverse prognosticator in gastric cancer. Hu Song 1, Qi-yu Liu 2, Zhi-wei
More informationHigh levels of long non-coding RNA DICER1-AS1 are associated with poor clinical prognosis in patients with osteosarcoma
European Review for Medical and Pharmacological Sciences 2018; 22: 7640-7645 High levels of long non-coding RNA DICER1-AS1 are associated with poor clinical prognosis in patients with osteosarcoma X.-H.
More informationOnly Estrogen receptor positive is not enough to predict the prognosis of breast cancer
Young Investigator Award, Global Breast Cancer Conference 2018 Only Estrogen receptor positive is not enough to predict the prognosis of breast cancer ㅑ Running head: Revisiting estrogen positive tumors
More informationUp-regulation of serum mir-4262 predicts clinical outcome of patients with acute myeloid leukemia
European Review for Medical and Pharmacological Sciences 2017; 21: 2172-2176 Up-regulation of serum mir-4262 predicts clinical outcome of patients with acute myeloid leukemia G.-T. HAN 1, Z.-L. SUN 2 1
More informationmicrorna Presented for: Presented by: Date:
microrna Presented for: Presented by: Date: 2 micrornas Non protein coding, endogenous RNAs of 21-22nt length Evolutionarily conserved Regulate gene expression by binding complementary regions at 3 regions
More informationRNA-Seq profiling of circular RNAs in human colorectal Cancer liver metastasis and the potential biomarkers
Xu et al. Molecular Cancer (2019) 18:8 https://doi.org/10.1186/s12943-018-0932-8 LETTER TO THE EDITOR RNA-Seq profiling of circular RNAs in human colorectal Cancer liver metastasis and the potential biomarkers
More informationOriginal Article MicroRNA-27a acts as a novel biomarker in the diagnosis of patients with laryngeal squamous cell carcinoma
Int J Clin Exp Pathol 2016;9(2):2049-2053 www.ijcep.com /ISSN:1936-2625/IJCEP0014841 Original Article MicroRNA-27a acts as a novel biomarker in the diagnosis of patients with laryngeal squamous cell carcinoma
More informationExon 19 L747P mutation presented as a primary resistance to EGFR-TKI: a case report
Case Report Exon 19 L747P mutation presented as a primary resistance to EGFR-TKI: a case report Yu-Ting Wang, Wei-Wei Ning, Jing Li, Jian-n Huang Department of Respiratory Medicine, the First ffiliated
More informationLncRNA GHET1 predicts a poor prognosis of the patients with non-small cell lung cancer
European Review for Medical and Pharmacological Sciences 2018; 22: 2328-2333 LncRNA GHET1 predicts a poor prognosis of the patients with non-small cell lung cancer Q.-M. SHEN 1,2, H.-Y. WANG 1,2, S. XU
More informationClinical value of combined detection of mir 1202 and mir 195 in early diagnosis of cervical cancer
ONCOLOGY LETTERS 17: 3387-3391, 2019 Clinical value of combined detection of mir 1202 and mir 195 in early diagnosis of cervical cancer XIELAN YANG 1, ZHILING YAN 1, HONGYING YANG 1, HUIJING NI 1, LEI
More informationHigh Expression of Forkhead Box Protein C2 is Related to Poor Prognosis in Human Gliomas
DOI:http://dx.doi.org/10.7314/APJCP.2014.15.24.10621 RESEARCH ARTICLE High Expression of Forkhead Box Protein C2 is Related to Poor Prognosis in Human Gliomas Yao-Wu Wang 1, Chun-Li Yin 2, Hong-Yi Zhang
More informationInt J Clin Exp Pathol 2016;9(3): /ISSN: /IJCEP
Int J Clin Exp Pathol 2016;9(3):3430-3435 www.ijcep.com /ISSN:1936-2625/IJCEP0019237 Original Article Down-regulation of mir-182 and mir-183 acts as potential predictor biomarkers in progression, metastasis,
More informationImplications of microrna-197 downregulated expression in esophageal cancer with poor prognosis
Implications of microrna-197 downregulated expression in esophageal cancer with poor prognosis T.-Y. Wang 1, S.-G. Liu 2, B.-S. Zhao 2, B. Qi 2, X.-G. Qin 2 and W.-J. Yao 2 1 Department of Biochemistry
More informationIncreased long noncoding RNA LINP1 expression and its prognostic significance in human breast cancer
European Review for Medical and Pharmacological Sciences 2018; 22: 8749-8754 Increased long noncoding RNA LINP1 expression and its prognostic significance in human breast cancer X.-M. LIU 1, B. YANG 2,
More informationLack of association between an insertion/ deletion polymorphism in IL1A and risk of colorectal cancer
Lack of association between an insertion/ deletion polymorphism in IL1A and risk of colorectal cancer H. Yan 1 *, R. Sun 2 *, X. Pan 3, Z. Li 4, X. Guo 5 and L. Gao 6 1 Department of Hepatobiliary Surgery,
More informationmir-125a-5p expression is associated with the age of breast cancer patients
mir-125a-5p expression is associated with the age of breast cancer patients H. He 1 *, F. Xu 2 *, W. Huang 1, S.Y. Luo 1, Y.T. Lin 1, G.H. Zhang 1, Q. Du 1 and R.H. Duan 1 1 The State Key Laboratory of
More informationGUOPEI LUO, PhD, MD. Shanghai Cancer Center, Shanghai, China. Joint-trained Ph.D. student, from 2008 to 2009, University of California, Irvine
GUOPEI LUO, PhD, MD EDUCATION Shanghai Cancer Center, Shanghai, China Joint-trained Ph.D. student, from 2008 to 2009, University of California, Irvine Ph.D. student specialized in pancreatic cancer, from
More informationOriginal Article microrna-217 was downregulated in ovarian cancer and was associated with poor prognosis
Int J Clin Exp Pathol 2016;9(8):8555-8559 www.ijcep.com /ISSN:1936-2625/IJCEP0026997 Original Article microrna-217 was downregulated in ovarian cancer and was associated with poor prognosis Qiong Pan,
More informationReview Article Long Noncoding RNA H19 in Digestive System Cancers: A Meta-Analysis of Its Association with Pathological Features
BioMed Research International Volume 2016, Article ID 4863609, 8 pages http://dx.doi.org/10.1155/2016/4863609 Review Article Long Noncoding RNA H19 in Digestive System Cancers: A Meta-Analysis of Its Association
More informationCancer incidence and patient survival rates among the residents in the Pudong New Area of Shanghai between 2002 and 2006
Chinese Journal of Cancer Original Article Cancer incidence and patient survival rates among the residents in the Pudong New Area of Shanghai between 2002 and 2006 Xiao-Pan Li 1, Guang-Wen Cao 2, Qiao
More informationPrognostic significance of nemo like kinase in nasopharyngeal carcinoma
MOLECULAR MEDICINE REPORTS 10: 131-136, 2014 Prognostic significance of nemo like kinase in nasopharyngeal carcinoma SIZE CHEN 1,2*, ZHIJIAN MA 3*, XUEMEI CHEN 4 and JIREN ZHANG 1 1 Department of Oncology,
More informationResearch Article Expression and Clinical Significance of the Novel Long Noncoding RNA ZNF674-AS1 in Human Hepatocellular Carcinoma
BioMed Research International Volume 2016, Article ID 3608914, 5 pages http://dx.doi.org/10.1155/2016/3608914 Research Article Expression and Clinical Significance of the Novel Long Noncoding RNA ZNF674-AS1
More informationOriginal Article Downregulation of microrna-26b functions as a potential prognostic marker for osteosarcoma
Int J Clin Exp Pathol 2016;9(6):6506-6510 www.ijcep.com /ISSN:1936-2625/IJCEP0024531 Original Article Downregulation of microrna-26b functions as a potential prognostic marker for osteosarcoma Zhihong
More informationGenome-wide association study of esophageal squamous cell carcinoma in Chinese subjects identifies susceptibility loci at PLCE1 and C20orf54
CORRECTION NOTICE Nat. Genet. 42, 759 763 (2010); published online 22 August 2010; corrected online 27 August 2014 Genome-wide association study of esophageal squamous cell carcinoma in Chinese subjects
More informationLong non-coding RNA ROR is a novel prognosis factor associated with non-small-cell lung cancer progression
European Review for Medical and Pharmacological Sciences 2017; 21: 4087-4091 Long non-coding RNA ROR is a novel prognosis factor associated with non-small-cell lung cancer progression C.-H. QU 1, Q.-Y.
More informationInvestigation on ERCC5 genetic polymorphisms and the development of gastric cancer in a Chinese population
Investigation on ERCC5 genetic polymorphisms and the development of gastric cancer in a Chinese population L.Q. Yang 1, Y. Zhang 2 and H.F. Sun 3 1 Department of Gastroenterology, The Second Affiliated
More informationGenetic variability of genes involved in DNA repair influence treatment outcome in osteosarcoma
Genetic variability of genes involved in DNA repair influence treatment outcome in osteosarcoma M.J. Wang, Y. Zhu, X.J. Guo and Z.Z. Tian Department of Orthopaedics, Xinxiang Central Hospital, Xinxiang,
More informationCancer Cell Research 19 (2018)
Available at http:// www.cancercellresearch.org ISSN 2161-2609 LncRNA RP11-597D13.9 expression and clinical significance in serous Ovarian Cancer based on TCGA database Xiaoyan Gu 1, Pengfei Xu 2, Sujuan
More informationOriginal Article The programmed death-1 gene polymorphism (PD-1.5 C/T) is associated with non-small cell lung cancer risk in a Chinese Han population
Int J Clin Exp Med 2014;7(12):5832-5836 www.ijcem.com /ISSN:1940-5901/IJCEM0002117 Original Article The programmed death-1 gene polymorphism (PD-1.5 C/T) is associated with non-small cell lung cancer risk
More informationPlasma Bmil mrna as a potential prognostic biomarker for distant metastasis in colorectal cancer patients
Title Plasma Bmil mrna as a potential prognostic biomarker for distant metastasis in colorectal cancer patients Author(s) Pun, JC; Chan, JY; Chun, BK; Ng, KW; Tsui, SY; Wan, TMH; Lo, OSH; Poon, TCJ; Ng,
More informationOriginal Article MicroRNA-101 is a novel biomarker for diagnosis and prognosis in breast cancer
Int J Clin Exp Pathol 2017;10(3):3279-3285 www.ijcep.com /ISSN:1936-2625/IJCEP0022926 Original Article MicroRNA-101 is a novel biomarker for diagnosis and prognosis in breast cancer Na Wei, Qing Ni, Min
More informationClinical significance of serum mir-21 in breast cancer compared with CA153 and CEA
Original Article Clinical significance of serum mir-21 in breast cancer compared with CA153 and CEA Jianjian Gao, Qingyun Zhang, Jianjun Xu, Lijuan Guo, Xuefeng Li Key Laboratory of Carcinogenesis and
More informationStudy on the expression of MMP-9 and NF-κB proteins in epithelial ovarian cancer tissue and their clinical value
Study on the expression of MMP-9 and NF-κB proteins in epithelial ovarian cancer tissue and their clinical value Shen Wei 1,a, Chen Juan 2, Li Xiurong 1 and Yin Jie 1 1 Department of Obstetrics and Gynecology,
More informationClinical significance of serum mir-196a in cervical intraepithelial neoplasia and cervical cancer
Clinical significance of serum mir-196a in cervical intraepithelial neoplasia and cervical cancer P. Liu 1, F. Xin 1 and C.F. Ma 2 1 Department of Obstetrics & Gynecology, Baoding Second Central Hospital,
More informationDr Catherine Woolnough, Hospital Scientist, Chemical Pathology, Royal Prince Alfred Hospital. NSW Health Pathology University of Sydney
Dr Catherine Woolnough, Hospital Scientist, Chemical Pathology, Royal Prince Alfred Hospital NSW Health Pathology University of Sydney Thyroid Cancer TC incidence rates in NSW Several subtypes - Papillary
More informationLong non-coding RNA FEZF1-AS1 is up-regulated and associated with poor prognosis in patients with cervical cancer
European Review for Medical and Pharmacological Sciences 2018; 22: 3357-3362 Long non-coding RNA FEZF1-AS1 is up-regulated and associated with poor prognosis in patients with cervical cancer H.-H. ZHANG
More informationReview Article Elevated expression of long noncoding RNA UCA1 can predict a poor prognosis: a meta-analysis
Int J Clin Exp Med 2016;9(6):9656-9664 www.ijcem.com /ISSN:1940-5901/IJCEM0025465 Review Article Elevated expression of long noncoding RNA UCA1 can predict a poor prognosis: a meta-analysis Tao Chen 1*,
More informationIncreased expression of the lncrna BANCR and its prognostic significance in human osteosarcoma
Increased expression of the lncrna BANCR and its prognostic significance in human osteosarcoma Z.Q. Peng 1, R.B. Lu 2, D.M. Xiao 3 and Z.M. Xiao 1 1 Department of Orthopedics, The First Affiliated Hospital
More informationCorrelation between expression and significance of δ-catenin, CD31, and VEGF of non-small cell lung cancer
Correlation between expression and significance of δ-catenin, CD31, and VEGF of non-small cell lung cancer X.L. Liu 1, L.D. Liu 2, S.G. Zhang 1, S.D. Dai 3, W.Y. Li 1 and L. Zhang 1 1 Thoracic Surgery,
More informationEvaluation of mir-182/mir-100 Ratio for Diagnosis and Survival Prediction in Bladder Cancer
Original Article Evaluation of mir-182/mir-100 Ratio for Diagnosis and Survival Prediction in Bladder Cancer Zhanguo Chen MD PhD 1, Lili Wu BA 2, Qi Lin BA 3, Jing Shi MD 4, Xiangyang Lin MD, Liang Shi
More informationA meta-analysis of the effect of microrna-34a on the progression and prognosis of gastric cancer
European Review for Medical and Pharmacological Sciences 2018; 22: 8281-8287 A meta-analysis of the effect of microrna-34a on the progression and prognosis of gastric cancer Z. LI 1, Z.-M. LIU 2, B.-H.
More informationExpression level of microrna-195 in the serum of patients with gastric cancer and its relationship with the clinicopathological staging of the cancer
European Review for Medical and Pharmacological Sciences 2016; 20: 1283-1287 Expression level of microrna-195 in the serum of patients with gastric cancer and its relationship with the clinicopathological
More informationOriginal Article Artemin promotes proliferation and metastasis in human laryngeal squamous cell carcinoma
Int J Clin Exp Pathol 2017;10(10):10413-10418 www.ijcep.com /ISSN:1936-2625/IJCEP0058793 Original Article Artemin promotes proliferation and metastasis in human laryngeal squamous cell carcinoma Chao-Bing
More informationOverregulation of microrna-212 in the poor prognosis of esophageal cancer patients
Overregulation of microrna-212 in the poor prognosis of esophageal cancer patients B. Qi 1, S.G. Liu 1, X.G. Qin 1, W.J. Yao 1, J.G. Lu 1, L. Guo 1, T.Y. Wang 2, H.C. Li 1 and B.S. Zhao 1 1 Department
More informationClaudin-4 Expression in Triple Negative Breast Cancer: Correlation with Androgen Receptors and Ki-67 Expression
Claudin-4 Expression in Triple Negative Breast Cancer: Correlation with Androgen Receptors and Ki-67 Expression Mona A. Abd-Elazeem, Marwa A. Abd- Elazeem Pathology department, Faculty of Medicine, Tanta
More informationMicroRNA-21 expression is associated with overall survival in patients with glioma
Wu et al. Diagnostic Pathology 2013, 8:200 RESEARCH Open Access MicroRNA-21 expression is associated with overall survival in patients with glioma Lin Wu 1, Gang Li 2, Dayun Feng 2, Huaizhou Qin 2, Li
More informationOriginal Article Associations of deregulation of mir-365 and its target mrna TTF-1 and survival in patients with NSCLC
Int J Clin Exp Pathol 2015;8(3):2392-2399 www.ijcep.com /ISSN:1936-2625/IJCEP0005766 Original Article Associations of deregulation of mir-365 and its target mrna TTF-1 and survival in patients with NSCLC
More informationSurvival of patients with advanced lung adenocarcinoma before and after approved use of gefitinib in China
Thoracic Cancer ISSN 1759-7706 ORIGINAL ARTICLE Survival of patients with advanced lung adenocarcinoma before and after approved use of gefitinib in China Yu-Tao Liu, Xue-Zhi Hao, Jun-Ling Li, Xing-Sheng
More informationValue of serum galectin-3 and midkine level determination for assessing tumor severity in patients with thyroid cancer
148 Journal of Hainan Medical University 2017; 23(3): 148-152 Journal of Hainan Medical University http://www.hnykdxxb.com Value of serum galectin-3 and midkine level determination for assessing tumor
More informationCirculating microrna-137 is a potential biomarker for human glioblastoma
European Review for Medical and Pharmacological Sciences Circulating microrna-137 is a potential biomarker for human glioblastoma H.-Y. LI, Y.-M. LI, Y. LI, X.-W. SHI, H. CHEN 2016; 20: 3599-3604 Department
More informationLack of association between ERCC5 gene polymorphisms and gastric cancer risk in a Chinese population
Lack of association between ERCC5 gene polymorphisms and gastric cancer risk in a Chinese population J.J. Lu, H.Q. Zhang, P. Mai, X. Ma, X. Chen, Y.X. Yang and L.P. Zhang Gansu Provincial Hospital, Donggang
More informationmirna Dr. S Hosseini-Asl
mirna Dr. S Hosseini-Asl 1 2 MicroRNAs (mirnas) are small noncoding RNAs which enhance the cleavage or translational repression of specific mrna with recognition site(s) in the 3 - untranslated region
More informationTemporal Trends in Demographics and Overall Survival of Non Small-Cell Lung Cancer Patients at Moffitt Cancer Center From 1986 to 2008
Special Report Temporal Trends in Demographics and Overall Survival of Non Small-Cell Lung Cancer Patients at Moffitt Cancer Center From 1986 to 2008 Matthew B. Schabath, PhD, Zachary J. Thompson, PhD,
More informationClinicopathological Factors Affecting Distant Metastasis Following Loco-Regional Recurrence of breast cancer. Cheol Min Kang 2018/04/05
Abstract No.: ABS-0075 Clinicopathological Factors Affecting Distant Metastasis Following Loco-Regional Recurrence of breast cancer 2018/04/05 Cheol Min Kang Department of surgery, University of Ulsan
More informationMiR-508-5p is a prognostic marker and inhibits cell proliferation and migration in glioma
European Review for Medical and Pharmacological Sciences MiR-508-5p is a prognostic marker and inhibits cell proliferation and migration in glioma Y.-H. LIU 1, B. LI 1, F.-G. MENG 1, L. QIU 2 2017; 21:
More informationOriginal Article Increased LincRNA ROR is association with poor prognosis for esophageal squamous cell carcinoma patients
Int J Clin Exp Pathol 2017;10(4):4654-4660 www.ijcep.com /ISSN:1936-2625/IJCEP0048142 Original Article Increased LincRNA ROR is association with poor prognosis for esophageal squamous cell carcinoma patients
More informationBiomedical Research 2017; 28 (21): ISSN X
Biomedical Research 2017; 28 (21): 9497-9501 ISSN 0970-938X www.biomedres.info Analysis of relevant risk factor and recurrence prediction model construction of thyroid cancer after surgery. Shuai Lin 1#,
More informationThe Egyptian Journal of Hospital Medicine (July 2018) Vol. 72 (9), Page
The Egyptian Journal of Hospital Medicine (July 2018) Vol. 72 (9), Page 5298-5303 Prognostic Value of Platelet to Lymphocyte Ratio in Patients with Non-Small Cell Lung Cancer Mohammad Sabry Elkady, Ghada
More informationSerum IGF-1 and IGFBP-3 levels as clinical markers for patients with lung cancer
BIOMEDICAL REPORTS 4: 609-614, 2016 Serum IGF-1 and IGFBP-3 levels as clinical markers for patients with lung cancer FARUK TAS, ELIF BILGIN, DIDEM TASTEKIN, KAYHAN ERTURK and DERYA DURANYILDIZ Department
More informationDown-regulation of mir p is correlated with clinical progression and unfavorable prognosis in gastric cancer
European Review for Medical and Pharmacological Sciences 2018; 22: 5914-5919 Down-regulation of mir-1236-3p is correlated with clinical progression and unfavorable prognosis in gastric cancer X.-P. ZHU
More information