Late effects after HSCT

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1 Late effects after HSCT Yves Chalandon Hematology Division, University Hospital of Geneva (HUG) Switzerland Hôpitaux Universitaires de Genève

2 Company name Disclosures of: Yves Chalandon Research support Employee Consultant Stockholder Speakers bureau Novartis X X Bristol Myers Squibb X X Pfizer X Advisory board

3 Transplants Transplant activity worldwide ,000 12,000 Autologous Related Donor Unrelated Donor 10,000 8,000 6,000 4,000 2,000 0 '80 '81 '82 '83 '84 '85 '86 '87 '88 '89 '90 '91 '92 '93 '94 '95 '96 '97 '98 '99 '00 '01 '02 '03'04' '05 '06 '07 '08 '09 '10 CIBMTR

4 Transplants, % Trends in Transplants by Type and Recipient Age* <=20 yrs yrs yrs yrs >60 yrs Allogeneic Transplants Autologous Transplants * Transplants for AML, ALL, NHL, Hodgkin Disease, Multiple Myeloma

5 Aim of HSCT Cure from the primary disease Recovery of the health status go back to the normal Normal physical and psychological functioning Normal family, professional and social integration Good subjective well being

6 Outcomes of HSCT in selected diseases EA Copelan N Engl J Med, 2006

7 One-Year Survival, % One-year survival after myeloablative conditioning for acute leukemias in any remission phase, CML or MDS, age <50 years, by year of transplant and graft source, HLA-matched sibling Unrelated Donor '91 '92 '93 '94 '95 '96 '97 '98 '99 '00 '01 '02 '03 '04 '05 '06 '07 '08 '09

8 Reduced mortality after allo-hsct over the past decade Gooley et al. N Engl J Med, 2010

9 Causes of Death after Transplants performed in HLA-identical Sibling Primary Disease (47%) New Malignancy (1%) GVHD (14%) Primary Disease (33%) Unrelated Donor New Malignancy (1%) GVHD (15%) Infection (12%) Organ Failure (4%) Other (21%) Primary Disease (73%) Autologous New Malignancy (1%) Other (29%) Organ Failure (6%) Infection (16%) Infection (8%) Organ Failure (2%) Other (16%)

10 Late morbidity and mortality in long term survivors Bhatia et al. Blood 2007

11 The mortality post-hsct = tip of iceberg The morbidity and late effects

12 Decrease health status after HSCT Chronic health condition after HSCT Grade 1= mild conditions Grade 5= death from chronic conditions C-L Sun et al. Blood 2010;116:3129

13 Decrease health status after HSCT 60-70% pts report at least 1 chronic condition 15-20% pts report severe/life-threatening cond At 10 yrs post-allohsct ~60% chronic health condition 10 yrs severe/death related chronic cond 35% HSCT pts twice as likely as sibling chronic cond HSCT 3.5 x severe/life-threatening cond If cgvhd 4.7 x severe/life-threatening cond C-L Sun et al. Blood 2010;116:3129

14 Decrease health status after HSCT Number of new late effect after auto or allo HSCT N Khera et al. JCO 2012;30:71

15 Decrease health status after HSCT also as compared to conventionally treated cancer survivors Prevalence of chronic health conditions among HSCT survivors (BMTSS) compared with conventionally treated cancer survivors (CCSS) and sibling controls (CCSS) in childhood Prevalence of adverse health status among HSCT survivors (BMTSS) compared with conventionally treated cancer survivors (CCSS) and sibling controls (CCSS) in childhood SH Armenian et al. Blood 2011;118:1413

16 Life after allohsct (long-term survivors) G. Socié et al. Blood 2003;101:3129 A.Tichelli et al. Expert Rev Hematol 2009;2:583

17 Causes of long-term effects after allohsct 1 Patient (age, gender, CMV, comorbidities ) 3 Conditioning 5 Graft Source Disease features 2 6 Supportive Care >180 4 GVHD prophylaxis and therapy

18 Late effects after HSCT Malignant late effects Non-malignant late effects Late relapses Endocrine dysfunction Secondary leukemia after Thyroid autohsct Gonadal, fertility Donor type leukemia of Growth and development secondary leukemia postallohsct Skeletal disorders Ocular, skin and mucosa troubles Secondary solid tumors Respiratory tract problems Liver complications Chronic kidney disorders Any organ or tissue can be Neurological complications the target of a late effects Cardio-vascular complications G. Socié et al. Blood 2003;101:3129 A.Tichelli et al. Expert Rev Hematol 2009;2:583

19 Time appearance of late effects Late effect= complications occurring 3 mths or later post-hsct compromising longterm survivorship A.Tichelli et al. Expert Rev Hematol 2009;2:583

20 Changes of pattern regarding the late effect over time

21 Relevant changes over time in HSCT procedures Conditioning regimen - MAC/RIC - TBI (doses and replaced by BU) Donor type Bone Marrow (BM) Peripheral Blood (PB) Cord Blood (CB) Age 20 yrs Age 20 yrs - Unrelated vs related donor Age of patients ( over years up to 75) Stem cell source - of PBSC and CB Indications for HSCT

22 Decrease of TBI in autohsct and over time use of TBI - Auto HSCT - Since year 2000 TBI related late effects in allohsct treated over the last yrs Organ function affected by TBI: - Fertility - Cataracts - Endocrine dysfunctions - Secondary solid tumors

23 Decrease use of TBI induces change of pattern of late effects Main risk factors for cataract: - TBI - Dose, fraction or not, dose rate - Steroids G. Socié et al. Blood 2003;101:3129 A.Tichelli et al. Expert Rev Hematol 2009;2:583

24 Transplants, % <=20 yrs yrs yrs yrs >60 yrs Allogeneic Transplants Autologous Transplants * Transplants for AML, ALL, NHL, Hodgkin Disease, Multiple Myeloma

25 Increase of GvHD over time induces increase in late effects and mortality

26 Late effect as a direct consequence of transplant procedure Intervention: Change in conditioning PreBMT intervention Early treatment G. Socié et al. Blood 2003;101:3129

27 Late effects can affect every organ

28 Evidence of premature cardiovascular event after allohsct A. Tichelli et al. Blood 2007;110:3463

29 Diabetes and hypertension are more frequent after allohsct than after autohsct or in sibling as well as after TBI

30 De novo cardiovascular risk factors are more frequent after allohsct than autohsct A. Tichelli et al. Blood 2007;110:3463

31 Early intervention on CV risk factor in long term survivors may prevent late CV complications Counseling and screening Dietary counseling Patients at risk should be encouraged to promptly report symptoms in HSCT clinic Heart healthy lifestyle - Stop smoking - Maintain BMI between Aerobic exercise - Psychological issues Screening? ECHO? ECG? BNP? Treatment Diabetes Dyslipidemia Hypertension Treat end organ damage Endocrine replacement? Treat sub-clinical cardiac dysfunction? Armenian et Bhatia Haematologica 2008;93:1132 Shankar et al. Pediatrics 2008;121:e387

32 Liver complications after HSCT cgvhd Chronic viral hepatitis and cirrhosis Hepatocellular carcinoma Iron overload Nodular regenerative hyperplasia

33 hypogonadism Iron overload after HSCT In up to 88% of long term survivors Due to prolonged dyserythropoiesis, iron absorption, transfusions Iron accumulation in liver, heart, gonads Effects: - Contribute to fibrosis, cirrhosis and hepatoca, cardiac dysfunction and higher incidence of fungal infections (mucor etc..) Other possible effects - Diabetes, impotence, growth retardation,

34 Late genito-urinary complication after HSCT Renal complications Gonadal failure and sexuality Gynecological cgvhd Fertility

35 Renal complications after HSCT Calcineurin inhibitors glomerular thrombosis, tubular injury and arteriopathy with interstitial fibrosis Antibiotics and antifungal tubular damages CMV infection glomerular lesions. CMV ttt with foscarnet tubulointerstitial nephritis and irreversible damage related to crystalization in renal tubules Radiation destruction of glomeruli and tubules + interstitial fibrosis TTP or microangiopathy renal failure

36 Gonadal failure and fertility Depends: - The age of the patient at time of transplant The younger the better chance of recovery - TBI: dose and fraction - Chemotherapy: type and dosage Conditioning regimen - TBI Gy - CY 120 mg/kg - Etoposide 60 mg/kg - BU (16 (12.8) mg/kg) CY (120 mg/kg)

37 Fertility after HSCT in childhood and adolescence N= 344 pts from 7 centers, 60% Male Median age at study:19(12-35) yrs Median fup: 6 (3-12) yrs Overall infertility rate: 75% - 69% in male - 83% in female Fertility rate: - Malignancy: 21% - Non-malignancy: 42% Risk factors for infertility: Female: - Start of conditioning 13 yrs - BU conditioning Male: - TBI conditioning - Pre-pubertal HSCT A Borgmann-Staudt et al. BMT 2012;47:271

38 Pregnancies and complications compared to normal populations N Salooja et al. Lancet 2001;358:271

39 Spermatogenesis after HSCT A Rovo et al. ASH 2010

40 Paternity after HSCT A Rovo et al. ASH 2011

41 Secondary malignancies

42 Late malignancies Secondary cancers in long term cancer survivors A. Tichelli and G. Socié ASH 2010

43 MDS/ Leukemia after auto HSCT Secondary cancers in long term cancer survivors Lenz et al. JCO 2004

44 Solid tumors after allohsct JD. Rizzo et al. Blood 2009 ;113:1175

45 Solid tumors after allohsct JD. Rizzo et al. Blood 2009;113:1175

46 Breast cancers after allohsct DL. Friedman et al. Blood 2008;111:939

47 RIC may partially reduces late effects RIC acute toxicity Cumulative incidence and severity of chronic GvHD are not affected A.Tichelli EBMT course 2011

48 Knowing about late effects allows intervention at different levels A.Tichelli EBMT course 2011

49 Quality of life (QOL)

50 Decrease Quality of Life (QOL) in long term survivors HRQL HRQL HRQL HRQL HR: 0.35 (95% CI ) for workers Single Married Divorced/ separated With partner School/ training Disability insurance Working full time Working part time and disability insurance Working part time Without cgvhd With cgvhd N=124, between , med time from HSCT 7.3 (1-21) yrs QOL assessed with EORTC QLQ-C30 0 HR: 0.27 (95% CI ) for younger < 25 years years years >45 years S Bieri et al. BMT 2008;42:819

51 Social issues after HSCT (n=124) Prior to HSCT After HSCT Working full time Working part time % School/training Retired 1 2 Disability insurance (13 partial) S Bieri et al. BMT 2008;42:819

52 Familial issues (n=124) Prior to HSCT After HSCT Married Significant other Single Divorced/separated 3 18 Widowed S Bieri et al. BMT 2008;42:819

53 Significant changes of QLQ-C30 compared to an age adjusted healthy population EORTC QLQ-C30 Mean scores Mean scores P patients controls Physical function 83.9 (32.6) Role function 74.6 (32.6) Emotional function 72.2 (28.8) 82.8 < Cognitive function 74.7 (28.5) 86.5 < Social function 73.4 (31.9) 85.8 < Global quality of life 71.2 (21.6) 73.7 < 0.03 Dyspnea 27.4 (33.7) 14.3 < Sleep disturbance 32 (35.2) 20.4 < Financial impact 24.2 (33.8) 9 < S Bieri et al. BMT 2008;42:819

54 Conclusions Due to increased number of patients that live longer, late effects will be more and more important in the care of HSCT patients There is a change in the pattern of late effects due to increased use of RIC and use of TBI + age of pts Physicians and health care providers should take into account this important problem and try to impact on it with prevention measures, counseling and treatment that are needed Secondary malignancies should be looked after early enough to be able to treat them with a curative potential

55 Thank you for your attention 55

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