Validity of Colposcopy in the Diagnosis of Early Cervical Neoplasia. Dr. Olaniyan Olayinka Babafemi
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1 Validity of Colposcopy in the Diagnosis of Early Cervical Neoplasia Dr. Olaniyan Olayinka Babafemi
2 Objective QUANTIFICATION OF PERFORMANCE OF COLPOSCOPY IN DIAGNOSIS OF EARLY CERVICAL DISEASE TO ASSESS JUSTIFICATION FOR ITS ROLE.
3 Outline Background/Objective StudyDesign Data Results Summary/Conclusion Recommendations
4 Background THE COLPOSCOPE Introduced by HANS HINSELMANN 1925 A binocular microscope for visualising the cervix at magnifications of X6-40.
5 Background THE ROLE OF COLPOSCOPY Pap Smear Cervicography DVI Speculoscopy COLPOSCOPY VIA Discharge/ Follow-up Polar probe HPV DNA Thin prep Biopsy/ Treatment
6 Study Design: Meta-Analysis INCLUSION Original articles EXCLUSION Unsatis. Colposcopy Diagnostic colposcopy Screening colposcopy Directed Rx follow-up Rawdata Limited participation
7 Characteristics of selected studies TABLE 1. CHARACTERISTCS OF SELECTED STUDIES. Author & year Stafl & Mattingly 1973 [13]. Type of. Refferal indications 1. Atypical cytology 2. Suspect cytology 3. Positive cytology 4. Positive DVI No. of Intervention participants 659 Colposcopy/ Outcome measure Benedet et al 1976 [25]. 1. Atypical cytology 2. Positive cytology 3. Suspect cytology 549 Colposcopy/ Javaheri & Fejgin 1980 [26]. 1. Positive cytology 2. Positive DVI 903 Colposcopy/ Edebiri AA 1990 [27] 1. Positive cytology 2. Positive DVI 3. Clinical symptoms 222 Colposcopy/ Seshadri et al 1990 [28] 1. Positive cytology 2. Clinical symptoms 152 Colposcopy/ Benedet et al 1991[29]. 1. Positive cytology 3252 Colposcopy/ Kierkegaard et al 1994 [31]. 1. Positive cytology 783 Colposcopy/ Cristoforoni et al 1995[32]. DVI = Direct Visual Inspection 1. Positive cytology 188 Colposcopy/
8 Results TABLE 2. MEASURES OF EFFECTIVENESS OF COLPOSCOPY : (a) For Threshold Normal Versus All Grades Of Abnormal Tissue. Study No. of patients TP FP FN TN Prev (%) Sensitivity (%) Specificity (%) Positive predictive value (%) Negative predictive value (%) Stafl & Mattingly [13] Benedet et al [25] Javaheri & Fejgin [26] Edebiri [27] Seshadri et al [28] Benedet et al [29] Kierkegaard et al [31] Cristoforoni et al [32] Mean TP = True positive ; FP = False positive ; TN = True negative ; FN = False negative ; Prev = Prevalence.
9 Results TABLE 2. MEASURES OF EFFECTIVENESS OF COLPOSCOPY : (b) For Threshold Normal & LSIL Versus HSIL. Study No. of patients TP FP FN TN Sensitivity (%) Specificity (%) Positive predictive value (%) Negative predictive value (%) Stafl and Mattingly [13] Benedet et al [25] Javaheri & Fejgin [26] 903 * * * * * * * * Edebiri [27] Seshadri et al [28] Benedet et al [29] Kierkegaard et al [31] Cristoforoni et al [32] Mean LSIL = Low Grade Squamous Intrepithelial Neoplasia ; HSIL = High Grade Squamous Intraepithelial Neoplasia.*Not ammenable to stratification.
10 Likelihood ratio of colposcopy for identifying normal from all grades of abnormal tissue TABLE Likelihood Ratios of Colposcopy For Identifying Normal Tissue From All Grades Of Abnormal Tissue. STUDY DIAGNOSIS No. In EACH STRATUM PROPORTION OF BIOPSY POSITIVE PROPORTIO N OF BIOPSY NEGATIVE LIKELIHOOD RATIO Stafl & Mattingly [13] Negative 48 6/499 42/ LSIL /499 66/ HSIL /499 52/ Total 659 Benedet et al [25] Negative 62 2/436 60/ LSIL 69 41/436 28/ HSIL /436 25/ Total 549 Javaheri & Fejgin [26] Negative 195 1/ / CIN I-II /681 21/ CIN III /681 7/ Total 903 Edebiri [27] Negative 79 17/130 62/ LSIL 33 20/130 13/ HSIL /130 17/ Total 222 Seshadri et al [28] Negative 37 9/70 28/ LSIL 49 13/70 36/ HSIL 66 48/70 18/ Total 152 Benedet et al [29] Negative / / LSIL / / HSIL / / Total 3252 Kierkegaard et al [31] Negative 59 29/726 30/57 0,08 LSIL /726 24/ HSIL /726 3/ Total 783 Cristoforoni et al [32] Negative 23 3/130 20/ LSIL /130 36/ HSIL 33 31/130 2/ Total 188
11 Results TABLE 4. Correlation Between Colposcopic and Histologic Diagnosis. Biopsy Worse Biopsy better Study Accuracy <<< << < concord. > >> >>> Total Stafl & Mattingly [13] Benedet et al [25] Javaheri & Fejgin [26] Edebiri [27] Seshadri et al [28] Benedet et al [29] Kierkegaard et al [31] Cristoforoni et al [32] Total % of total ACCURACY = 89.40%
12 Summary Colposcopic accuracy = 89% Concordance (Bx) = 61% Sensitivity = 87-99% Specificity = 26-87% Positive predictive value increases with disease severity.
13 Conclusion/Recommendation Colposcopy is an accurate and valid tool for the diagnosis of early cervical disease. Implication for Practice:- Endocervical - To be or not to be? Implication for Research:- Colposcopy via Internet- Telecolposcopy, is a potential means of extending colposcopy training & services to areas of low technical expertise.
14 Acknowledgement MY THANKS GO TO MY SUPERVISOR DR. SALONEY NAZEER FOR POINTING THE DIRECTION
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