KNOWING YOUR FAMILY HEALTH HISTORY COULD SAVE YOUR LIFE!
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- Jesse Calvin Elliott
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1 KNOWING YOUR FAMILY HEALTH HISTORY COULD SAVE YOUR LIFE! Why is my family health history so important? Several important reasons to know your family health history! Because some conditions run in families and by asking about your family health history, you can find out what diseases you and your children may be at increased risk for getting.! Depending upon the disease and your risk level (see below) you may meet criteria for more or different kinds of prevention/screening. MeTree calculates your risk from the information you enter and tells you what options are available to lower your risk.! How much your risk is increased depends upon the type of risk you have. There are two kinds of RISK: 1. Familial risk. This means you have a slightly higher chance (about 2-3 times higher) of getting the disease than most people outside your family. An example of a family history for familial risk is a mother with colon cancer after age Hereditary risk. This means you have a much higher chance (50-100%) of getting the disease than most people outside your family. These risks are inherited from a parent through DNA segments (genes) and are not common (only about 1 in 500 people have them). An example of a family history that might indicate risk for hereditary risk is a parent with colon cancer at age 40.
2 What does it mean to have a higher risk for cancer? Examples of risk, both Familial Risk and Hereditary Risk! Breast cancer occurs in 1 out of 9 women; this means the average person has an 11% chance of getting breast cancer in their lifetime (called population risk). If you have a familial risk for breast cancer then you would have a 22-33% chance of having breast cancer in your lifetime.! Hereditary risk (risks inherited from a parent through genes), if you have hereditary breast and ovarian cancer syndrome you have an 80% chance of getting breast cancer in your lifetime.! The chart below illustrates the risk differences between population risk, familial risk and hereditary risk:
3 What exactly is a family health history and what do I ask about? Family members health and how to collect the information! A family health history is a record of your blood family members (parents, grandparents, aunts/uncles, brothers/sisters, children, and cousins). Your partner and his/her relatives are not your blood relatives and therefore, their family health history is not helpful in determining your risk! Record relationship to you (mother, grandmother on mom s side, etc.), any disease they had, the age they developed the disease, and if they have died -what age they died and what the cause of death was.! A worksheet with a list of all the conditions you should ask family members about is provided at the end of this document.! As you saw in the description of familial vs. hereditary risk it is very important to know how old someone was when they developed a disease.! Important distinctions to make when asking about cancers.! Most cancers start in one site (site of origin) but often they will spread to other places (metastases). For example lung cancer can frequently spread to the brain.! When asking about cancer we only need to know the site of origin. The other sites are not helpful in assessing your risk level.
4 How do I ask about family health history? Who to ask and where to start! Family members are the best source of information.! Start with your parents if they are still alive! Often there is on family member who is considered the family historian and knows everything about everyone. If there is a person like this in your family you should talk with him/her.! Family events like birthdays, Christmas, and weddings are an excellent time to ask, because so many relatives are in one place. In fact, Thanksgiving is a national family health history day and would be a great time to bring it up!! Some relatives are uncomfortable talking about health and/or medical histories. If that happens to you, you can explain how it will help you and your children Why do I also have to provide information about myself? Your health information is also important! To perform a risk assessment for some conditions like hereditary cancer syndromes or hereditary liver diseases you only need family health history to calculate risk; however other diseases need information about yourself and your lifestyle to fully calculate your risk.! Examples of these include cholesterol and blood pressure for heart disease risk, radiation exposure for breast cancer risk, and diet for diabetes risk.
5 MeTree asks about the following tests for yourself. Check to see if you ve had any of these tests and what the results were.! Cholesterol: including total, LDL (bad cholesterol), HDL (good cholesterol), and triglycerides (fat)! HgbA1c: a marker of your average sugar levels for the last 3 months, used in diabetes screening and management! High sensitivity CRP (hscrp): a marker of inflammation used to measure risk of heart disease! Carotid Artery Intimal Medial Thickness (CA-IMT): an ultrasound measuring the thickness of the carotid arteries (it s not the same as just measuring the blood flow inside the arteries which is called a carotid ultrasound)! Coronary Calcium CT Score: measures calcium deposits in the heart blood vessels
6 MeTree asks about the following family health history. Please talk with family members to see if anyone has been with any of these conditions. Types of Cancer:! Bone! Liver (or Hepatocellular)! Skin! Brain! Lung! Small Bowel! Breast (both or just one?)! Muscle (or Sarcoma)! Stomach! Colon! Ovarian! Thyroid! Esophageal! Pancreatic! Uterine! Kidney (or Renal cell)! Prostate! Unknown! Leukemia! Rectal Hereditary Cancer Syndromes (these are uncommon and require a genetic test):! Hereditary Breast & Ovarian Cancer Syndrome! Lynch Syndrome (also called Hereditary Nonpolyposis Colon Cancer)! Familial Adenomatous Polyposis! LiFraumeni Syndrome! Cowden Syndrome Hereditary Cardiovascular Syndromes (these are uncommon and require a specialist for care):! Familial hypercholesterolemia! Long QT syndrome! Hypertrophic Cardiomyopathy! Brugada syndrome! Dilated Cardiomyopathy! Catecholaminergic polymorphic ventricular tachy! Left ventricular non-compaction syndrome! Arrhythmogenic right ventricular dysplasia! Ehlers Danlos syndrome! Marfans syndrome
7 Hereditary Liver Diseases:! Hemochromatosis! Primary Biliary Cirrhosis! Wilson s Disease! Auto-immune hepatitis! Alpha 1 Anti-trypsinase Deficiency! Sclerosing Cholangitis Hereditary Blood Clotting Diseases:! Protein C deficiency! Prothrombin 2010 mutation! Protein S deficiency! Factor V Leiden! Anti-thrombin 3 deficiency Other Diseases:! Aortic Aneurysm! Multiple Sclerosis! Asthma! Osteoporosis! Atrial Fibrillation! Parkinson s Disease! Dementia/Alzheimers! Peripheral Artery Disease! Carotid Stenosis! Rheumatoid Arthritis! Colon Polyps! Sickle Cell Trait/Disease! Crohn s disease! Sudden cardiac death! COPD (chronic bronchitis or! Stroke Emphysema)! Diabetes (specify type: type 1,! Thalessemia type 2, gestational (during pregnancy only))! Heart Attack! Thyroid Disease! High Blood Pressure! Ulcerative Colitis! High Cholesterol! Addiction (drugs or alcohol)! Lupus! Kidney Disease (specify type: nephritis, nephrotic, cystic, diabetes, unknown)! Mental Illness
8 Causes of Death:! Accident! Natural Causes! Cancer! SIDS! Diabetes! Stroke! Heart Disease! Unknown! Infection! Other! Lung Disease (ex. copd)
9 Family History Worksheet Your Children Diseases this person has had and age they were Your Brothers and Sisters Diseases this person has had and age they were Your Nieces and Nephews Diseases this person has had and age they were * If you don t know their exact age, put approximate age.
10 Your Parents Mom Dad Diseases this person has had and age they were Your aunts and uncles on your Mom s side Diseases this person has had and age* they were Your grandparents on your Mom s side grandmother Diseases this person has had and age* they were grandfather * If you don t know their exact age, put approximate age.
11 Your aunts and uncles on your Dad s side Diseases this person has had and age* they were Your grandparents on your Dad s side grandmother r at Diseases this person has had and age* they were grandfather * If you don t know their exact age, put approximate age.
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