Computational & Systems Biology Immunology

Transcription

1 Computational & Systems Biology Immunology UNIVERSITY OF PITTSBURGH SCHOOL OF MEDICINE RETREAT 2017 June 7, 2017 Twentieth Century Club

2 Highlights Keynote Address Steve Kleinstein, Ph.D. 8:40 AM - 9:40 AM ( ) Associate Professor of Pathology Yale University School of Medicine Faculty Talks 9:40 AM - 11:30 AM (morning session) 1:30 PM - 3:10 PM (afternoon session) See attached title list (see page 4). Round Tables 11:30 AM - 12:30 PM Round Table Discussion 2nd fl Lecture Hall 12:30 PM - 1:30 PM Meet the Expert Round tables Poster Session Odd Posters: 3:10 PM - 4:00 PM Even Posters: 4:00 PM - 5:00 PM See attached title list (see page 6). (Light bites will be provided) 2

3 Morning Session 8:30 AM - 8:40 AM 8:40 AM - 9:40 AM 9:40 AM - 10:00 AM 10:00 AM- 10:20 AM 10:20 AM - 10:30 AM 10:30 AM - 10:50 AM 10:50 AM - 11:10 AM 11:10 AM - 11:30 AM 11:30 AM - 12:30 PM 12:30 PM - 1:30 PM Afternoon Session 1:30 PM - 1:50 PM 1:50 PM - 2:10 PM 2:10 PM - 2:30 PM 2:30 PM - 2:50 PM 2:50 PM - 3:10 PM 3:00 PM - 5:00 PM 5:00 PM - 5:30 PM Welcome/Opening remarks (Ivet Bahar and Mark Shlomchik) Keynote - Dr. Steve Kleinstein Anne-Ruxandra Carvunis (CSB) Bill Hawse (Immuno) Coffee Break Takis Benos (CSB) Lisa Borghesi (Immuno) Carlos Camacho (CSB) Transition to round tables Round table discussion Lunch Break / Round tables Meet the Expert round tables Florian Weisel (Immuno) Chakra Chennubhotla (CSB) Sandra Cascio (Immuno) Jim Faeder (CSB) Dario Vignali (Immuno) Transition to poster session Poster Session Reception Awards and Closing Remarks 2nd fl Lecture Hall 1st fl Ballroom 1st fl Ballroom 3

4 Titles Talks Anne-Ruxandra Carvunis Assistant Professor, Computational & Systems Biology Of mice, men, network modeling and immune systems Bill Hawse Research Assistant Professor, Immunology Proteomic profiling identifies novel kinase signaling networks that drive T cell differentiation Takis Benos Professor, Computational & Systems Biology Causal modeling and its application to various disease/problems Lisa Borghesi Associate Professor, Immunology Constructing a Human B Cell Atlas using Computational Flow Cytometry and Unsupervised Approaches Carlos Camacho Associate Professor, Computational & Systems Biology How the immune system recognizes foreignness 4

5 Florian Weisel Research Assistant Professor, Immunology Memory B cell recall responses Chakra Chennubhotla Associate Professor, Computational & Systems Biology Computational spatial tumor pathology for phenotyping and immunotyping tumor microenvironments Sandra Cascio Research Assistant Professor, Immunology Validation of hypoglycosylated MUC1-CIN85 protein-protein interaction as a new therapeutic target for prevention of cancer invasion and metastasis Jim Faeder Associate Professor, Computational & Systems Biology Systems biology modeling of immune pathways Dario Vignali Professor, Immunology Single cell RNAseq analysis of immune populations in cancer 5

6 Posters 1. Andreas Vogt A Tumor Cell-Selective Inhibitor of Mitogen-Activated Protein Kinase Phosphatases Causes Apoptosis, Enhances Lymphokine-Activated Killer Cell Activity and Activates Peripheral Blood Mononuclear Cells 2. Shu Wang Systematic association analysis of immune checkpoint blockade of PD -1 by RNA-seq data in advanced melanoma patients 3. Dimitrios Manatakis Causal Discovery on Pulmonary Hypertension Mixed Datasets 4. Tian Du Gene Expression Analysis Reveals Unique Immune Response in Invasive Lobular Breast Carcinoma 5. Jingyu Zhang Cells Interpret Temporal Information From TGF-β Through A Nested Relay Mechanism. 6. Deepali Sawant Regulatory T cell-derived inhibitory cytokines, IL35 and IL10, induce expression of multiple inhibitory receptors on tumor-infiltrating T cells 7. Bing Liu Systems-level Insights into Immune Regulation from Quantitative Modeling 8. Henry Ma Evaluation of Electrocardiography for Determing Diseasea nd Outcome Following aerosol Infection of Macaques with Equine Encephalitis Viruses 9. Hongchun Li Dynamic Modulation of Binding as a Mechanism for Regulating Interferon Signaling 6

7 10. Samir el Abdouni Integration of structure- and genomics- based screening to target immunological diseases 11. Marta Wells Structure-Based Discovery of Novel Glycinergic Modulators 12. Anthony R. Cillo Single cell RNAseq analysis of immune populations in patients with cancer 13. Gibran Biswas Using Computational Methods to Target the Immunoreceptor TIGIT 14. Abigail E Overacre-Delgoffe IFN-gamma drives Treg fragility to promote anti-tumor immunity 15. Hyokyeong Lee Cancer Immunotherapy: In search of pathways in metastatic melanoma using T-cell signature and anergy genes 16. Zoltan Oltavi Environment-induced transition from stochastic to spatially-ordered enzyme expression heterogeneity in cancer cell metabolism 17. Abstract withdrawn 18. Rebecca Elsner Salmonella enterica does not require Salmonella-specific B cells and is associated with blocked T follicular helper cell differentiation 19. Gabriele Farina Sequential Planning for Steering Immune System Adaptation 20. Amanda Clark A multi-organ microphysiological system that models dormantemergent metastatic breast cancer progression in a pharmacorelevant manner 21. Nicolas Pabon How PD-1 s flexible interface enables selective binding promiscuity 22. Jason Lohmueller msa2 biotin-binding CAR T cells for universal tumor targeting 7

8 23. Justin Spiriti Flexible Docking of Breast Cancer Drug Candidates to ER-α Using Mixed-Resolution Monte Carlo 24. Abstract Withdrawn 25. Sandra Cascio Validation of hypoglycosylated MUC1-CIN85 protein-protein interaction as a new therapeutic target for prevention of cancer invasion and metastasis 26. Jiyoung Lee Dynamics and ligand-binding properties of γ-secretase investigated by the Anisotropic Network Model and Molecular Simulations 27. Ashley Nelson ELL2 shifts gene expression by affecting alternative splicing in antibody secreting cells 28. Sanjana Gupta Dose discrimination in TNF-NFkB signaling 29. Lisa Borghesi Constructing a Human B Cell Atlas using Computational Flow Cytometry and Unsupervised Approaches 30. Weikang Wang Single Cell Segmentation with Deep Convolutional Neural Networks 31. Qiuhong Zhang Quantitative Single Cell Responses to Inflammatory Signals 32. Xueer Chen Systematic Study of Tumor-specific Immune Evasion Mechanisms 33. Xiaojun Tian Single Cell Segmentation with Deep Convolutional Neural Networks 34. Abstract withdrawn 35. Jocelyn Sunseri GPU Implementation of Molecular Docking with Receptor Flexibility 36. David Schipper Cellular responses to dynamic patterns of cytokine stimulation 8