p16 Genetic Test Reporting Counseling Protocol Flip Chart
|
|
- Zoe Singleton
- 6 years ago
- Views:
Transcription
1 p16 Genetic Test Reporting Counseling Protocol Flip Chart
2 Chromosomes, Gene, & Protein Cell Nucleus Chromosomes Gene Protein Adapted from Understanding Gene Testing,, NIH, 1995
3 Cancer Normal cell Disease of the cells Abnormal reproduction of cells causing an overload First mutation Second mutation Third mutation Malignant cell Fourth + mutation
4 All Cancer is Genetic Not All Cancer is Inherited Normal cell First mutation First mutation Second mutation Second mutation Third mutation Cancer cell Fourth + mutation Third mutation Cancer cell Fourth + mutation
5 Melanoma Is Sporadic or Hereditary Hereditary Sporadic MM, 56 MM x 2 Non MM Skin cancer MM 57 MM 25 MM 40 3 or more melanomas in a family Multiple MM in one individual Melanoma and pancreatic cancer Family history of melanoma or other skin cancers
6 The Development of Hereditary Cancer 2 normal genes 1 damaged gene 2 damaged genes 1 normal gene Tumor develops In hereditary cancer, one damaged gene is inherited. 1 damaged gene 1 normal gene 2 damaged genes Tumor develops
7 What Is Melanoma? Deadly skin cancer Begins in Melanocytes Tendency to spread
8
9 Relative Risk for Developing Melanoma (Relative risk indicates degree of increased risk compared to the general population) Risk Factor Skin Type I (fair skin) Freckling Blue Eyes Red Hair History of blistering sunburn 6 atypical nevi 10 dysplastic nevi 100 or more nevi* Family history of melanoma ** Previous primary cutaneous melanoma Member of melanoma prone family*** Member of a melanoma prone family, no personal hx melanoma, dysplastic nevi Member of melanoma prone family, personal hx melanoma, dysplastic nevi Approximate/Estimated Relative Risk Up to *Relative risk in the UK population ** One or more affected first-degree relatives *** Multiple affected relatives on the same side of the family
10 Melanoma is a multi-step process Adapted from Bennett, D. Oncogene 2003.
11
12 The p16 Gene p16 gene Chromosome 9
13 How p16 is Inherited Parents p16 / p16 p16 / p16 Children (50% chance) p16 / p16 p16 / p16 p16 / p16 p16 / p16
14 p16 Risk for Cancer Melanoma Pancreatic? Other Melanoma Pancreatic? Other
15 Other Recent epidemiological evidence suggests that members of melanoma prone families may be at a higher risk for the following cancers: Breast Prostate Non- Hodgkin's Lymphoma Colon Multiple Myeloma CNS
16 Risk of Melanoma in p16 Mutation Carriers By age 50 By age 80 Risk in general population Risk in p16 mutation carriers in the United States <1% 1% ~50% ~76% J Natl Cancer Inst 2002; 94:
17 Risk of Pancreatic Cancer in p16 Mutation Carriers By age 75 Risk in general population Risk in some p16 mutation carriers ~ 1% 1 ~17% Int J Cancer 2000;87:809-11
18 Melanoma Risk in p16 positive vs. p16 negative Lifetime risk to carriers 53 times that of general population 33 times that of non-carrier family members within a p16 family Lifetime risk to non-carriers in mutation carrying family ~1.7 fold higher than general population
19 Managing the Cancer Risk of p16 Mutations Lifestyle: Minimize sun exposure Prevent sunburns Surveillance: Monthly self-exams Clinical exam every 6-12 months (begin age 10) Baseline photography of entire body (where available) Surgical: Prophylactic excision of suspicious nevi J Clin Oncol 1999;17:
20 Medical Management of Melanoma All individuals in familial melanoma families, regardless of p16 status, should have: Baseline total body skin exam at 10y w/ characterization of moles mole-mapping helpful and self skin exam education Physical exam every 6 mo until nevi stable and pt is capable of self exam (more freq - puberty & pregnancy) Monthly total body self-examination of skin Sun protection measures
21 Sun Avoidance and Protection
22 Sun Avoidance and Protection Prevention Avoid the sun between 10 am & 4 pm. Seek shade! Use sunblock with SPF 30 or higher. Re-apply every 2 hours Wear protective clothing Screening & Early Detection Practice skin self exam. Watch for growth or changes in a growth or mole Report any changes to your doctor
23 Interpreting a Negative Result MM MM + p16 mutation MM MM MM MM -p16 mutation MM Inconclusive -p16 mutation True negative Adapted from ASCO
Corporate Medical Policy Genetic Testing for Cutaneous Malignant Melanoma
Corporate Medical Policy Genetic Testing for Cutaneous Malignant Melanoma File Name: Origination: Last CAP Review: Next CAP Review: Last Review: genetic_testing_for_cutaneous_malignant_melanoma 8/2011
More informationUnderstanding Your Genetic Test Result. Positive for a Deleterious Mutation or Suspected Deleterious
Understanding Your Genetic Test Result Positive for a Deleterious Mutation or Suspected Deleterious This workbook is designed to help you understand the results of your genetic test and is best reviewed
More informationMELANOMA. Some people are more likely to get a m Melanoma than others:
MELANOMA This leaflet has been written to help you understand more about Melanoma. It tells you what is it, what causes it, what can be done about it, how it can be prevented, and where you can find out
More informationMELANOMA. 4 Fitzroy Square, London W1T 5HQ Tel: Fax: Registered Charity No.
MELANOMA This leaflet had been written to help you understand more about melanoma. It tells you what it is, what causes it, what can be done about it, how it can be prevented, and where you can find out
More informationDermatology for the PCP Deanna G. Brown, MD, FAAD Susong Dermatology Consulting Staff at CHI Memorial
Dermatology for the PCP Deanna G. Brown, MD, FAAD Susong Dermatology Consulting Staff at CHI Memorial Cutaneous Oncology for the PCP Deanna G. Brown, MD, FAAD Susong Dermatology Consulting Staff at CHI
More informationToby Maurer, MD University of California, San Francisco. Lifetime risk of an American developing melanoma
Distinguishing Pigmented Skin Lesions and Melanoma Toby Maurer, MD University of California, San Francisco Epidemiology of Melanoma Lifetime risk of an American developing melanoma 1935: 1 in 1500 1980:
More informationToby Maurer, MD University of California, San Francisco. Lifetime risk of an American developing melanoma
Distinguishing Pigmented Skin Lesions and Melanoma Toby Maurer, MD University of California, San Francisco Epidemiology of Melanoma Lifetime risk of an American developing melanoma 1935: 1 in 1500 1980:
More informationMelanoma: The Basics. What is a melanocyte?
Melanoma: The Basics What is a melanocyte? A melanocyte is a normal cell, found in the skin, which produces melanin. Melanin is a black or dark brown pigment that is seen in the skin, hair, and parts of
More informationHereditary Breast and Ovarian Cancer Rebecca Sutphen, MD, FACMG
Hereditary Breast and Ovarian Cancer 2015 Rebecca Sutphen, MD, FACMG Among a consecutive series of 11,159 women requesting BRCA testing over one year, 3874 responded to a mailed survey. Most respondents
More informationThey can develop anywhere on the skin and also inside the mouth. They can develop in normal skin or where there is an existing skin mole.
What are malignant melanomas? Malignant melanomas are one type of skin cancer. They can develop anywhere on the skin and also inside the mouth. They can develop in normal skin or where there is an existing
More informationDO YOU HAVE A FAMILY HISTORY OF ONE OF THESE CANCERS? BREAST, OVARIAN, COLORECTAL, ENDOMETRIAL, PANCREAS, PROSTATE, STOMACH OR SKIN CANCERS?
DO YOU HAVE A FAMILY HISTORY OF ONE OF THESE CANCERS? BREAST, OVARIAN, COLORECTAL, ENDOMETRIAL, PANCREAS, PROSTATE, STOMACH OR SKIN CANCERS? IF SO, ASK YOUR DOCTOR IF THE PREVENTEST CAN HELP PREDICT YOUR
More informationClinicians Role in Reducing the Risk of Skin Cancer: Barriers and Solutions
Clinicians Role in Reducing the Risk of Skin Cancer: Barriers and Solutions Kelly Nelson, MD Associate Professor MD Anderson Cancer Center University of Texas USPSTF recommendations Grade Definition Suggestions
More informationLiving Beyond Cancer Skin Cancer Detection and Prevention
Living Beyond Cancer Skin Cancer Detection and Prevention Cutaneous Skin Cancers Identification Diagnosis Treatment options Prevention What is the most common cancer in people? What is the most common
More informationCancer Facts for Women
Cancer Facts for Women Some of the cancers that most often affect women are breast, colorectal, endometrial, lung, cervical, skin, and ovarian cancers. Knowing about these cancers and what you can do to
More informationGenetic Testing for Familial Cutaneous Malignant Melanoma
MP 2.04.33 Genetic Testing for Familial Cutaneous Malignant Melanoma Medical Policy Section Medicine Issue 12:2013 Original Policy Date 12:2013 Last Review Status/Date Reviewed with literature search/12:2013
More informationTHE MODERN GYNECOLOGIC EXAMINATION & SCREENING FOR GYNECOLOGIC MALIGNANCIES
THE MODERN GYNECOLOGIC EXAMINATION & SCREENING FOR GYNECOLOGIC MALIGNANCIES Denise Uyar, MD Associate Professor OB/GYN Chief Gynecologic Oncology Medical College of Wisconsin April 12, 2019 NO DISCLOSURES
More informationJill Stopfer, MS, CGC Abramson Cancer Center University of Pennsylvania
Jill Stopfer, MS, CGC Abramson Cancer Center University of Pennsylvania Aging Family history Early menarche Late menopause Nulliparity Estrogen / Progesterone use after menopause More than two alcoholic
More informationchapter 8 CANCER Is cancer becoming more common? Yes and No.
chapter 8 CANCER In Canada, about 4% of women and 45% of men will develop cancer at some time in their lives, and about 25% of the population will die from cancer. 1 Is cancer becoming more common? Yes
More information*
Introduction Cancer is complex, can have many possible causes, and is increasingly common. For the U.S. population, 1 in 2 males and 1 in 3 females is at risk of developing cancer in their lifetime. The
More informationDoes Cancer Run in Your Family?
Does Cancer Run in Your Family? Nancie Petrucelli, MS, CGC Clinical Assistant Professor Certified Genetic Counselor/Coordinator Cancer Genetic Counseling Service Karmanos Cancer Institute Wayne State University
More information6/8/17. Genetics 101. Professor, College of Medicine. President & Chief Medical Officer. Hereditary Breast and Ovarian Cancer 2017
Genetics 101 Hereditary Breast and Ovarian Cancer 2017 Rebecca Sutphen, MD, FACMG Professor, College of Medicine President & Chief Medical Officer INVASIVE CANCER GENETICALLY ALTERED CELL HYPERPLASIA DYSPLASIA
More informationSun Safety and Skin Cancer Prevention. Maryland Skin Cancer Prevention Program
Sun Safety and Skin Cancer Prevention Maryland Skin Cancer Prevention Program Do You Know the Facts About Skin Cancer? Skin cancer is the most common cancer but also the most preventable Childhood sunburn
More informationManagement of BRCA Positive Breast Cancer. Archana Ganaraj, MD February 17, 2018 UPDATE ON WOMEN S HEALTH
Management of BRCA Positive Breast Cancer Archana Ganaraj, MD February 17, 2018 UPDATE ON WOMEN S HEALTH The number of American women who have lost their lives to breast cancer outstrips the total number
More informationCANCER Uncontrolled Cell Division
CANCER Uncontrolled Cell Division What is cancer? Why does it occur? Where does it occur? Benign vs. Malignant? Types of Cancer (3 main groups) There are over 200 different types of cancer 1) Carcinomas
More informationSteven Robinson. Steven Robinson Memorial Endowment at
fchwmt.org Steven Robinson Steven Robinson Memorial Endowment at Fair hair and skin Steven s story Grew up around water and loved being outdoors Experienced several sunburns as a child and young adult
More informationHereditary Aspects of Pancreatic Cancer
Pancreatic Cancer Seminar San Francisco, CA Hereditary Aspects of Pancreatic Cancer Genetic Risk Assessment and Counseling for Familial Pancreatic Cancer February 3, 2016 Amie Blanco, MS, CGC Gordon and
More informationImportance of Family History in Gynecologic Cancer Prevention. Objectives. Genetic Counselors. Angela Thompson, MS, CGC
Importance of Family History in Gynecologic Cancer Prevention Angela Thompson, MS, CGC Genetic Counselor Froedtert & The Medical College of Wisconsin Objectives Introduce role of genetic counselor Discuss
More informationSkin Cancer 101: Diagnosis and Management of the Most Common Cancer
Skin Cancer 101: Diagnosis and Management of the Most Common Cancer Sarah Patton, PA-C, MSHS Skin Surgery Center www.skinsurgerycenter.com Seattle/Bellevue, WA Skin cancer Skin cancer is by far the most
More informationHealthy Skin Education in Alabama s Schools. Alabama Comprehensive Cancer Control Program
Healthy Skin Education in Alabama s Schools Alabama Comprehensive Cancer Control Program Skin cancer is the most common form of cancer in the US. Skin cancer is the uncontrolled growth of abnormal skin
More informationHereditary breast cancer who to refer to a cancer genetics clinic and how to counsel patients with
Hereditary breast cancer who to refer to a cancer genetics clinic and how to counsel patients with positive and negative results? SAMO Workshop Luzern 3./4.10.2014 Dr. med. Barbara Bolliger TumorTumor-
More informationOncology 101. Cancer Basics
Oncology 101 Cancer Basics What Will You Learn? What is Cancer and How Does It Develop? Cancer Diagnosis and Staging Cancer Treatment What is Cancer? Cancer is a group of more than 100 different diseases
More informationPrevention. Skin cancer is the most common cancer in the. The Science of. by Laura Brockway-Lunardi, Ph.D.
66 DERMASCOPE June 2012 The Science of Prevention by Laura Brockway-Lunardi, Ph.D. Skin cancer is the most common cancer in the U.S. with more than two million Americans diagnosed annually. Basal cell
More informationCancer Facts for Men FOR REVIEW ONLY
Cancer Facts for Men Prostate cancer The chance of getting prostate cancer goes up as a man gets older. Most prostate cancers are found in men over the age of 65. For reasons that are still unknown, African
More informationVACAVILLE DERMATOLOGY
Connecting the Dots on those Spots NANDAN V. KAMATH, M.D. VACAVILLE DERMATOLOGY Sources All of the photos were taken with permission from the Dermnet NZ website - Dermnet New Zealand after communicating
More informationCutaneous Melanoma: Epidemiology (USA) The Sentinel Node in Head and Neck Melanoma. Cutaneous Melanoma: Epidemiology (USA)
The Sentinel Node in Head and Neck Melanoma Cutaneous Melanoma: Epidemiology (USA) 6 th leading cause of cancer among men and women 68,720 new cases of invasive melanoma in 2009 8,650 deaths from melanoma
More informationDermatological Manifestations in the Elderly. Sanjay Siddha Staff Dermatologist UHN & MSH
Dermatological Manifestations in the Elderly Sanjay Siddha Staff Dermatologist UHN & MSH Disclosure No actual or potential conflicts of interest or commercial relationships to declare Objectives Recognize
More informationVIP MedSpa Clinic News
Maryam Hekmat, M.D. Inc. May 2017 VIP MedSpa Clinic News VIPMedSpaClinic.com 858-451-6500 11665 Avena Place, Suite 104 San Diego, CA 92128 Medical News Can B12 Shots Boost My Energy and Help Me Lose Weight?
More informationWELCOME. Taking Care of Your Health. April 30, 8 am to noon
WELCOME Taking Care of Your Health April 30, 8 am to noon Cancer: Know Your Risk Emily Kuchinsky, MS, CGC, Certified Genetic Counselor Sporadic Cancer Lifetime Probability- Women Family Cluster Risk factors
More informationOral and Maxillofacial Surgery Department
Oral and Maxillofacial Surgery Department This leaflet explains: Lentigo Maligna What are the aims of this leaflet? This leaflet has been written to help you understand more about lentigo maligna and melanoma
More informationAssessing Your Patient s Breast Cancer Risk: Is Genetic Testing Necessary?
May 16, 2016 Assessing Your Patient s Breast Cancer Risk: Is Genetic Testing Necessary? Presenter: Emily Kuchinsky, MS, CGC 1 Experiences with Genetic Testing Adverse Events in Cancer Genetic Testing:
More informationTotal body photography in high risk patients
Total body photography in high risk patients Doug Grossman, MD, PhD Department of Dermatology Huntsman Cancer Institute University of Utah Summer AAD F032 Practical Considerations for Patients with Melanoma
More informationMelanoma. Lynn Schuchter, M.D. Associate Professor of Medicine Abramson Cancer Center of the University of Pennsylvania
Melanoma Lynn Schuchter, M.D. Associate Professor of Medicine Abramson Cancer Center of the University of Pennsylvania WHAT IS MELANOMA? Melanoma is a type of skin cancer (a serious skin cancer because
More informationSo how much of breast and ovarian cancer is hereditary? A). 5 to 10 percent. B). 20 to 30 percent. C). 50 percent. Or D). 65 to 70 percent.
Welcome. My name is Amanda Brandt. I am one of the Cancer Genetic Counselors at the University of Texas MD Anderson Cancer Center. Today, we are going to be discussing how to identify patients at high
More informationAcute: Symptoms that start and worsen quickly but do not last over a long period of time.
Cancer Glossary Acute: Symptoms that start and worsen quickly but do not last over a long period of time. Adjuvant therapy: Treatment given after the main treatment. It usually refers to chemotherapy,
More informationC1 Qu2 DP2 High levels of preventable chronic disease, injury and mental health problems - Cancer
C1 Qu2 DP2 High levels of preventable chronic disease, injury and mental health problems - Cancer Hey guys, In the last video we explored CVD. The next compulsory priority area to look at is cancer. In
More informationSUN & SKIN CANCER CANCER INSIGHT WHAT YOU NEED TO KNOW ABOUT FOR PRACTICE NURSES INSIDE: A3 poster to display in your surgery.
CANCER INSIGHT FOR PRACTICE NURSES Summer 2018 WHAT YOU NEED TO KNOW ABOUT SUN & SKIN CANCER Th in k No sun n protectio SUNBUR Y? N TODA TE TO HI G ERA ion, especia H ect OD prot M ut sun o ab 4 5 lly
More informationMole mapping and monitoring. Dr Stephen Hayes. Associate Specialist in Dermatology, University Hospital Southampton
Mole mapping and monitoring Dr Stephen Hayes Associate Specialist in Dermatology, University Hospital Southampton Outline of presentation The melanoma epidemic Benefits of early detection Risks of the
More informationAre you at risk of Hereditary Cancer? Your Guide to the Answers
Are you at risk of Hereditary Cancer? Your Guide to the Answers What is Hereditary Cancer? The genes we are born with may contribute to our risk of developing certain types of cancer, including breast,
More informationIT S FUNDAMENTAL MY DEAR WATSON! A SHERLOCKIAN APPROACH TO DERMATOLOGY
IT S FUNDAMENTAL MY DEAR WATSON! A SHERLOCKIAN APPROACH TO DERMATOLOGY Skin, Bones, and other Private Parts Symposium Dermatology Lectures by Debra Shelby, PhD, DNP, FNP-BC, FADNP, FAANP Debra Shelby,
More informationTreatments used Topical including cleansers and moisturizer Oral medications:
Discipline: Dermatology Extended Topic: Acne & Rosacea : Onset: Location: Face Chest Back Menses if female: Regular Irregular PCOS Treatments used Topical including cleansers and moisturizer Oral medications:
More informationThe Sun: Friend or Foe
The Sun: Friend or Foe Vitamin D (The Sunshine Vitamin) There is a relationship between low vitamin D levels and poor bone health. Links have been made to everything from multiple sclerosis to prostate
More informationCancer Prevention and Early Detection Worksheet for Men
Page 1 of 5 Cancer Prevention and Early Detection Worksheet for Men While a tremendous amount of progress has been made in cancer research, we still don t understand exactly what causes most cancers. However,
More informationSkin Cancer Awareness
Skin Cancer Awareness Presented by BHS Call: 800-327-2251 Visit: www.bhsonline.com 2016 BHS. All rights reserved. 1 Training Summary More than 3.5 million new cases of skin cancer will be diagnosed in
More informationCancer Survivorship Symposium Cancer and Heredity January 16, Jeanne P. Homer, MS Licensed Certified Genetic Counselor
Cancer Survivorship Symposium Cancer and Heredity January 16, 2017 Jeanne P. Homer, MS Licensed Certified Genetic Counselor Outline Cancer and Heredity Hereditary Cancer Risk Assessment & Genetic testing
More informationSUN & SKIN CANCER CANCER INSIGHT WHAT YOU NEED TO KNOW ABOUT FOR PHARMACY STAFF INSIDE: A3 poster to display in your pharmacy.
CANCER INSIGHT FOR PHARMACY STAFF Summer 2018 WHAT YOU NEED TO KNOW ABOUT SUN & SKIN CANCER Th in k No sun n protectio SUNBUR Y? N TODA TE TO HI G ERA ion, especia H ect OD prot M ut sun o ab 4 5 lly 11
More informationHow The Skin Tans. How The Skin Tans
How The Skin Tans How The Skin Tans Our natural skin colour is determined by skin pigment melanin and the presence and amount of melanin in an individual is determined by hereditary factors. When our skin
More informationTO SERVE YOU MORE EFFICIENTLY, PLEASE COMPLETE THIS FORM AND RETURN IT TO THE FRONT DESK BEFORE YOU ARE CALLED TO AN EXAM ROOM. THANK YOU.
NEW PATIENT FORM TO SERVE YOU MORE EFFICIENTLY, PLEASE COMPLETE THIS FORM AND RETURN IT TO THE FRONT DESK BEFORE YOU ARE CALLED TO AN EXAM ROOM. THANK YOU. DATE: ACCOUNT NUMBER: AGE: NAME: DATE OF BIRTH:
More informationCancer Genetics. What is Cancer? Cancer Classification. Medical Genetics. Uncontrolled growth of cells. Not all tumors are cancerous
Session8 Medical Genetics Cancer Genetics J avad Jamshidi F a s a U n i v e r s i t y o f M e d i c a l S c i e n c e s, N o v e m b e r 2 0 1 7 What is Cancer? Uncontrolled growth of cells Not all tumors
More informationProtocol. Genetic Testing for Familial Cutaneous Malignant Melanoma
Protocol Genetic Testing for Familial Cutaneous Malignant Melanoma (20444) Medical Benefit Effective Date: 01/01/12 Next Review Date: 11/18 Preauthorization No Review Dates: 09/10, 09/11, 01/12, 01/13,
More informationEnvironmental Health and Safety. Sun Safety. Greg Hogan Oklahoma State University Environmental Health and Safety (405)
Sun Safety Greg Hogan Oklahoma State University Environmental Health and Safety (405) 744-7241 Current as of June 2018 Objective The Skin Cancer Problem The Sun and Your Skin Assessing Your Personal Risk
More informationDescription. Page: 1 of 12. Genetic Testing for Familial Cutaneous Malignant Melanoma. Last Review Status/Date: December 2014
Last Review Status/Date: December 2014 Page: 1 of 12 Description Because some cases of cutaneous malignant melanoma (CMM) are familial, potential genetic markers for this disease are being evaluated. Some
More informationGenetics of Pancreatic Cancer. October 6, If you experience technical difficulty during the presentation:
Genetics of Pancreatic Cancer October 6, 2016 If you experience technical difficulty during the presentation: Contact WebEx Technical Support directly at: US Toll Free: 1-866-229-3239 Toll Only: 1-408-435-7088
More informationSkin Cancer - Non-Melanoma
Skin Cancer - Non-Melanoma Introduction Each year, millions of people find out that they have skin cancer. Skin cancer is almost 100% curable if found early and treated right away. It is possible to prevent
More informationCANCER INSIGHT. FOR GPs. Summer 2018 WHAT YOU NEED TO KNOW ABOUT SKIN CANCER VISIT. our Skin Cancer Recognition Toolkit at
CANCER INSIGHT FOR GPs Summer 2018 WHAT YOU NEED TO KNOW ABOUT SKIN CANCER VISIT our Skin Cancer Recognition Toolkit at www.doctors.net. uk/sct Cancer Research UK, Angel Building, 407 St John Street, London
More informationHIGH LEVELS OF PREVENTABLE CHRONIC DIEASE, INJURY AND MENTAL HEALTH PROBLEMS
HIGH LEVELS OF PREVENTABLE CHRONIC DIEASE, INJURY AND MENTAL HEALTH PROBLEMS Let s look at CANCER AS A WHOLE. What is the nature of the problem? Well, cancer is the growth of cells within the body. We
More informationWhat All of Us Should Know About Cancer and Genetics
What All of Us Should Know About Cancer and Genetics Beth A. Pletcher, MD, FAAP, FACMG Associate Professor of Pediatrics UMDNJ- New Jersey Medical School Disclosures I have no relevant financial relationships
More informationOutline. Identifying your risk for hereditary breast or ovarian cancer. Genetics 101. What causes cancer? Genetics
Identifying your risk for hereditary breast or ovarian cancer David Andorsky, MD Breanna Roscow, MS, CGC 303-993-0161 Outline Genetics and biology of hereditary cancer syndromes BRCA1 and BRCA2 Genetic
More informationFigure 1. Comparison of Cancer Incidence Rates 1 of Individual Census Tracts with Louisiana, All Cancers Combined,
Figure. Comparison of Cancer Incidence Rates of Individual Census Tracts with Louisiana, All Cancers Combined, 006-04 The rate is statistically significantly lower than Louisiana The rate is not statistically
More informationCurrent Trends in Melanoma Theresa Medina, MD UCD Cutaneous Oncology
Current Trends in Melanoma Theresa Medina, MD UCD Cutaneous Oncology Overview Melanoma incidence and prevention Approach to surgical management of early melanoma Landscape of Advanced Melanoma Therapy
More informationApproximately 5% to 10% of breast cancer (BC) is hereditary in nature. Since. By Dawna Gilchrist, MD, FRCPC, FCCMG
By Dawna Gilchrist, MD, FRCPC, FCCMG Approximately 5% to 10% of breast cancer (BC) is hereditary in nature. Since the discovery of the genes BRCA 1 and 2 in the early 1990s, genetic counselling and testing
More informationHow can we reduce the mortality from melanoma in Australia?
How can we reduce the mortality from melanoma in Australia? Professor Grant McArthur MB BS PhD Peter MacCallum Cancer Centre Melbourne, Australia University of Melbourne, Parkville, Australia What is melanoma?
More informationA Glance at Cancer in Waterloo Region
Building Healthy and Supportive Communities A Glance at Cancer in Waterloo Region This is one of a series of Public Health Perspectives reports developed by Region of Waterloo Public Health. It focuses
More informationCancer in Huron County
Cancer in Huron County 2-29 Prepared by: Erica Clark, Epidemiologist April 214 77722B London Road RR 5, Clinton, ON NM 1L 519.482.3416 F: 519.482.782 www.huronhealthunit.com Cancer Health Status Report
More informationAllinaHealthSystems 1
Overview Biology and Introduction to the Genetics of Cancer Denise Jones, MS, CGC Certified Genetic Counselor Virginia Piper Cancer Service Line I. Our understanding of cancer the historical perspective
More informationAn Overview of Melanoma. Harriet Kluger, M.D. Associate Professor Section of Medical Oncology Yale Cancer Center
An Overview of Melanoma Harriet Kluger, M.D. Associate Professor Section of Medical Oncology Yale Cancer Center Melanoma Statistics Median age at presentation 45-55 55 years Incidence: 2003 54,200 cases
More informationSUBUNGUAL MALIGNANT MELANOMA ON THE RIGHT INDEX IN A DENTIST AFTER PROLONGED OCCUPATIONAL EXPOSURE TO X-RAYS
SUBUNGUAL MALIGNANT MELANOMA ON THE RIGHT INDEX IN A DENTIST AFTER PROLONGED OCCUPATIONAL EXPOSURE TO X-RAYS J. HATZIS*, V. MAKROPOULOS**, N. AGNANTIS*** * Department of Skin and Venereal Diseases, University
More informationBRCAplus. genetic testing for hereditary breast cancer
BRCAplus genetic testing for hereditary breast cancer Developed in collaboration with Fox Chase Cancer Center and the Arcadia University Genetic Counseling Program. Causes of Hereditary Breast Cancer familial
More informationCorporate Medical Policy
Corporate Medical Policy Gene Expression Profiling for Cutaneous Melanoma File Name: Origination: Last CAP Review: Next CAP Review: Last Review: gene_expression_profiling_for_cutaneous_melanoma 5/2018
More informationResult Navigator. Positive Test Result: CDKN2A. After a positive test result, there can be many questions about what to do next. Navigate Your Results
Result Navigator Positive Test Result: CDKN2A Positive test results identify a change, or misspelling, of DNA that is known or predicted to cause an increased risk for cancer. DNA is the blueprint of life
More informationDermatopathology: The tumor is composed of keratinocytes which show atypia, increase mitoses and abnormal mitoses.
Squamous cell carcinoma (SCC): A common malignant tumor of keratinocytes arising in the epidermis, usually from a precancerous condition: 1- UV induced actinic keratosis, usually of low grade malignancy.
More informationLimit Direct Sun Exposure
Summer is Too Hot. We love to be outdoors in the spring and the summer!!! We must take caution and protect our skin. May is Skin Cancer awareness month.. Skin Cancer Most avoidable of all cancers, skin
More informationMitosis Exploration Pd. Objective: Describe the purpose and process of cellular reproduction. 1. What is a cell?
Mitosis Exploration Name Pd Objective: Describe the purpose and process of cellular reproduction. Review: 1. What is a cell? 2. Describe the main differences between a prokaryotic and eukaryotic cell.
More informationwith a sunscreen. He had red hair, blue eyes, and his on the skin of the back and abdomen (Fig. 2). The
Journal ofmedical Genetics, 1978, 15, 352-356 Familial atypical multiple mole-melanoma syndrome HENRY T. LYNCH, BERT C. FRICHOT, III, AND JANE F. LYNCH From the Department ofpreventive Medicine/Public
More informationBREAST CANCER d an BREAST SELF EXAM
BREAST CANCER and BREAST SELF EXAM American Cancer Society Statistics: 2009 Invasive breast cancer will be diagnosed in over 192,370 women Carcinoma in situ will be diagnosed in 62,280 women More than
More informationCancer - the Beginning: Biology, Pathology and Genetic Predisposition
Cancer - the Beginning: Biology, Pathology and Genetic Predisposition Disclosure I have no conflicts of interest in relation to this program or presentation. Ashley V Daley, MS, CGC Genetic Counselor Virginia
More informationGenetic Panel Testing and Implications for Cancer Care
Genetic Panel Testing and Implications for Cancer Care Dana Zakalik, M.D. Nancy and James Grosfeld Cancer Genetics Center Professor, OUWB Medical School MCC Board of Directors Meeting September 28, 2016
More informationScreening for Genes for Hereditary Breast and Ovarian Cancer in Jewish Women
Screening for Genes for Hereditary Breast and Ovarian Cancer in Jewish Women Background About 5% of women in Canada with breast cancer and about 12% of women with ovarian cancer, are born with an inherited
More informationCancer statistics (US)
Disclosure I have no financial relationships to disclose Biology and Introduction to the Genetics of Cancer Vickie Matthias Hagen, MS, CGC Certified Genetic Counselor Virginia Piper Cancer Service Line
More informationGenetic testing and pancreatic disease
Genetic testing and pancreatic disease February 2 d, 2018 Yale Pancreas Symposium 2018: Multidisciplinary Management of Pancreatic Cancer Xavier Llor, M.D., PhD. Associate Professor of Medicine Co-Director,
More informationHBOC Syndrome A review of BRCA 1/2 testing, Cancer Risk Assessment, Counseling and Beyond.
HBOC Syndrome A review of BRCA 1/2 testing, Cancer Risk Assessment, Counseling and Beyond. Conni Murphy, ARNP Cancer Risk Assessment and Genetics Program Jupiter Medical Center Learning Objectives Identify
More informationCancer. Chapter 31 Lesson 2
Cancer Chapter 31 Lesson 2 Tumors All cancers are tumors- masses of tissue. Not all tumors are cancers. Some tumors are benign- noncancerous. These tumors are surrounded by membranes that prevent them
More informationMelanoma What It Is and How To Reduce Your Risk
www.melanomafocus.com Melanoma What It Is and How To Reduce Your Risk 1 Melanoma What It Is And How To Reduce Your Risk What is melanoma? It is a potentially serious form of cancer, usually starting in
More informationBRCA 1/2. Breast cancer testing THINK ABOUT TOMORROW, TODAY
BRCA 1/2 Breast cancer testing THINK ABOUT TOMORROW, TODAY 5 10% of patients with breast and/or ovarian cancer have a hereditary form1. For any individual carrying a mutation in BRCA1 or BRCA2, the lifetime
More informationSequencing. Deletion/Duplication Analysis. How Does Genetic Testing for Cancer Work?
There are several steps involved with genetic testing for cancer predisposition. The first step would be to meet with a specialist, such a genetic counselor, who can assess your medical and family history
More informationSkin cancer pictures scalp
Skin cancer pictures scalp Deadly skin cancer takes on many forms - If anything here looks familiar, get help. The Warning Signs of Skin Cancer. Skin cancers -- including melanoma, basal cell carcinoma,
More informationLPN2008 l Volume 4, Number 4
36 LPN2008 l Volume 4, Number 4 2.0 CONTACT HOURS PAMELA R. JAKUBEK, RN, CWOCN, MSN Wound, Ostomy, Continence Clinical Nurse Specialist ROBIN NEWMILLER, RN, BA Clinical Nurse for Mohs Clinical Suite Fox
More informationBRCA2 gene. Associated Syndrome Name: Hereditary Breast and Ovarian Cancer syndrome (HBOC) BRCA2 Summary Cancer Risk Table. BRCA2 gene Overview
BRCA gene Associated Syndrome Name: Hereditary Breast and Cancer syndrome (HBOC) BRCA Summary Cancer Risk Table Male Breast GENETIC RISK Female Breast Elevated Risk Elevated Risk BRCA gene Overview Hereditary
More informationA Patient s Guide to. Hereditary Ovarian Cancer: Is Hereditary Cancer Testing Right for You?
A Patient s Guide to Hereditary Ovarian Cancer: Is Hereditary Cancer Testing Right for You? What is Hereditary Cancer? Most cancers occur in people who do not have a strong family history of that cancer.
More informationSturdy Memorial Hospital Oncology Program. Brochure. Public Reporting of Outcomes. design
Sturdy Memorial Hospital Oncology Program Brochure Public Reporting of Outcomes 2017 Melanoma & Skin Cancer Prevention Brochure Skin cancer remains one of the top 10 cancer sites for people living in Massachusetts.
More information