Disclosure of Relevant Financial Relationships. Breast Pathology Evening Specialty Conference Case #4. Clinical Case: Pathologic Features

Size: px
Start display at page:

Download "Disclosure of Relevant Financial Relationships. Breast Pathology Evening Specialty Conference Case #4. Clinical Case: Pathologic Features"

Transcription

1 Breast Pathology Evening Specialty Conference Case #4 K.P. Siziopikou, MD, PhD Professor of Pathology Director of Breast Pathology and Breast Pathology Fellowship Program Northwestern University Feinberg School of Medicine Robert H. Lurie Comprehensive Cancer Center Disclosure of Relevant Financial Relationships USCAP requires that all planners (Education Committee) in a position to influence or control the content of CME disclose any relevant financial relationship WITH COMMERCIAL INTERESTS which they or their spouse/partner have, or have had, within the past 12 months, which relates to the content of this educational activity and creates a conflict of interest. Dr. Siziopikou has nothing to disclose. Clinical Case Mammography and ultrasound findings Clinical Case Needle core biopsy findings 33 yo G1P1 female presented with self-detected right breast mass at 3 months post partum Breast imaging showed an 1.9 cm mass at 1 o clock at 3 cm from the nipple corresponding to the palpable area of concern Ultrasound evaluation revealed a mass with posterior acoustic shadowing corresponding to the mammographic findings Breast Imaging also showed an enlarged axillary lymph node An US guided NCB was performed H-E PR ER Clinical Case: Pathologic Features Mastectomy: Breast Tumor Markers Following the NBC the patient underwent bilateral mastectomies, intraoperative evaluation of the sentinel node and right sided AXLD Final Pathology: Right breast mastectomy IDC, grade 3/3, 1.9 cm, with prominent lymphocytic reaction Breast mass ER/PR/: negative 1/14 lymph nodes with metastatic disease pt1c, N1a, Mx. Stage IIa Left breast mastectomy Benign breast findings Lymph node ER PR Ki 67

2 PABC: Definition Pregnancy Associated Breast Cancer (PABC) Breast cancer diagnosed during gestation, lactation and within 1 to 5 years postpartum Epidemiology A Ann Surg September; 46(3): nn Surg September; 46(3): Malignancy in pregnancy 1:2000 in 1964 to 1:1000 deliveries in 2000 Ann Surg September; 46(3): Voulgaris E, Pentheroudakis G and Pavlidis N. Cancer and pregnancy: a comprehensive review. Surg Oncol 2011;20:e Breast Cancer and Pregnancy Epidemiology (cont d) 6,000,000 pregnancies/year in the US 1 in 3,000 to 1 in 10,000 are associated with BC PABC constitutes % of all breast cancer cases PABC constitutes 25-30% of all premenopausal women diagnosed with breast cancer Breast cancer is the leading cause of cancer death in US women age Source: SEER data, DeSantis C, Ma J, Bryan L and Ahmedin J. Breast Cancer Statistics, CA: A Cancer Journal for Clinicians 2013;64(1):52 62.

3 Dual effects of Pregnancy on Breast Cancer Development Stages of Breast Development Meier Abt Trends Mol Med Mar;20(3): Lyons, TR, Schedin PJ and Borges VF. Pregnancy and breast cancer: when they collide. J Mammary Gland Biol Neoplasia 2009;14: Dual effects of Pregnancy on Breast Cancer Development Protective Pregnancy induced epithelial cell differentiation Changes in estrogen responsiveness of parous gland Diminution in number of mammary stem cells Britt et al. Pregnancy and the risk of breast cancer. Endocrine-Related Cancer (2007) Dual effects of Pregnancy on Breast Cancer Development Promoting Involutional changes post pregnancy, simulate wound healing/inflammatory environment increasing propensity for metastasis Altered hormone levels in parous women especially GH and prolactin Schedin, P. Pregnancy-associated breast cancer and metastasis. (2006) Britt et al. Pregnancy and the risk of breast cancer. Endocrine-Related Cancer (2007) Involution hypothesis Involution Hypothesis Mammary gland involution: fully differentiated milk-producing breast regresses to a pre-pregnant-like state Involves apoptotic cell death of 50-80% of the mammary epithelium Tissue-remodeling programs similar to wound healing and inflammation Wound healing and inflammation tumor progression, dissemination and metastasis Lyons, TR, Schedin PJ and Borges VF. Pregnancy and breast cancer: when they collide. J Mammary Gland Biol Neoplasia 2009;14:87-98.

4 PABC: Clinical Presentation Pathologic features of PABC Palpable breast mass Physiologic changes of pregnancy increased breast volume palpable nodularity firmness increased parenchymal density Usually presents as advanced disease Largest proportion of stages II-IV breast cancers Can be any subtype of BC Invasive ductal carcinoma (75-90%) Larger tumor size Higher grade Higher stage at presentation Higher rates of lymph node involvement (56-89%) PABC: Histologic Features PABC: IHC High frequency of hormone negative status 70% ER and PR negative with high ki67 ER PR More frequently triple negative ER, PR and Ki 67 Breast mass Lymph node If not TN, then often overexpression of Prognosis PABC: Genomic Signatures Worse prognosis in a matched case study (stage, age and year of diagnosis) 5-year OS 30.7% PABC vs. 48.7% non-pabc (p < ) Dimitrakakis C, Zagouri F, Tsigginou A et al. Does pregnancy-associated breast cancer imply a worse prognosis? A matched case-case study. Breast Care 2013;8: Hormonal milieu of pregnancy contributes to the aggressiveness of PABC PABC samples clustered with established breast cancer subtypes Harvell DME, Kim J, O Brien J, et al. Genomic signatures of pregnancy-associated breast cancer epithelia and stroma and their regulation by estrogens and progesterone. Horm Canc 2013;4:

5 PABC: Genomic Signatures of Tumor Cells PABC: Genomic Signatures of Stroma Hormone regulated genes differed in PABC vs. non PABC (malignant epithelium) Hormone regulated genes differed in PABC vs. non PABC (tumor associated stroma) Cell proliferation Cell metabolism Lipid metabolism Immune response immune related genes (macrophage response) Harvell DME, Kim J, O Brien J, et al. Genomic signatures of pregnancy-associated breast cancer epithelia and stroma and their regulation by estrogens and progesterone. Horm Canc 2013;4: Harvell DME, Kim J, O Brien J, et al. Genomic signatures of pregnancy-associated breast cancer epithelia and stroma and their regulation by estrogens and progesterone. Horm Canc 2013;4: PABC: Genomic Signatures The Inflammatory Microenvironment in Cancer Development and Progression 1,097 genes differentially expressed between PABC and non-pabc Overrepresented in PABC Cellular proliferation Cellular lipid catabolism Positive regulation of the immune system Lymphocyte activation Leukocyte differentiation The significant differences in genomic pathways support the involution hypothesis Development and prognosis of PABC May aid in the identification of unique therapeutic targets Tumor microenvironment: Blood vessels Fibroblasts Signaling molecules Extracellular matrix Inflammatory cells Inflammatory tumor microenvironment contributes to the biological behavior of cancer Harvell DME, Kim J, O Brien J, et al. Genomic signatures of pregnancy-associated breast cancer epithelia and stroma and their regulation by estrogens and progesterone. Horm Canc 2013;4: The Inflammatory Microenvironment in Cancer Development and Progression Inflammation Immune system: dual effect on human tumors: Immune responses against cancer CD8-positive lymphocytes in colon cancer favorable clinical course Permissive or tumor-promoting microenvironment Abundant CD68-positive macrophages in Hodgkin s lymphoma and Ewing s sarcoma adverse prognosis PABC diagnosed within 2 years of pregnancy grade 3 (76% vs. 26%) triple negative (34% vs. 3%) positive lymph nodes (61% vs. 45%) Kruger JM, Wemmert C, Sternberger L, et at. Combat or surveillance? Evaluation of the heterogeneous inflammatory breast cancer environment. J Pathol TAI 1+ TAI 2+ TAI 3+ L.Z. Blanco, Jr., A. Mahajan and K.P. Siziopikou: Tumor associated inflammation correlates with poor prognosis in pregnancy associated breast cancer. Modern Pathology, 26:30A, 2013.

6 TAI 0 TAI 1+ TAI 2+ TAI 3+ PABC 1 (3.8%) 12 (46.2%) 8 (30.8%) 5 (19.2%) CONTROLS 6 (27.3%) 13 (59.9%) 3 (13.6%) 0 (0%) Majority of PABC have tumor associated inflammation (TAI - 50% moderate or severe) Severe TAI more likely in PABC (1 in 5 cases) and absent in controls All 5 cases with severe TAI grade 3 tumors with positive lymph nodes Perilobular inflammation (PLI) away from the tumor PLI 1+ PLI 2+ PLI 3+ L.Z. Blanco, Jr., A. Mahajan and K.P. Siziopikou: Tumor associated inflammation correlates with poor prognosis in pregnancy associated breast cancer. Modern Pathology, 26:30A, L.Z. Blanco, Jr., A. Mahajan and K.P. Siziopikou: Tumor associated inflammation correlates with poor prognosis in pregnancy associated breast cancer. Modern Pathology, 26:30A, Inflammation (cont d) PLI 0 PLI 1+ PLI 2+ PLI 3+ PABC 4 (15.4%) 13 (50%) 6 (23.1%) 3 (11.5%) CONTROLS 10 (45.5%) 9 (40.9%) 1 (4.5%) 2 (9.1%) Immunohistochemical stains for T cells (CD4 and CD8) CD PABC 0 7 (35%) 13 (65%) CD PABC 0 9 (45%) 11 (55%) PABC more likely to have perilobular inflammation (85% vs. 55%) TAI and PLI may play an important role in tumor metastasis in PABC and contribute to the poor prognosis in these patients L.Z. Blanco, Jr., A. Mahajan and K.P. Siziopikou: Tumor associated inflammation correlates with poor prognosis in pregnancy associated breast cancer. Modern Pathology, 26:30A, CONTROLS 0 6 (40%) 9 (60%) Similar amounts of CD4+ lymphocytes PABC more abundant CD8+ lymphocytes CONTROLS 1 (7%) 11 (73%) 3 (20%) L.Z. Blanco, Jr., J. Ubago and K.P. Siziopikou: Increased CD68-positive Macrophages and CD4-positive Lymphocytes in Tumor Associated Inflammation correlates in Pregnancy Associated Breast Cancer May Contribute to a Poor Prognosis. Modern Pathology, 28:36A, CD4 CD8 PABC: PD-1/PD-L-1 expression Immunohistochemical stain for macrophages (CD68) PD-L1 is highly expressed in tumor infiltrating lymphocytes in PABC CD PABC 0 16 (80%) 4 (20%) CONTROLS 2 (13%) 13 (87%) 0 TILs PABC Controls p value PD-L Strong PD-L1 42.9% 0% 0.01 PABC more abundant CD68+ macrophages CD68 All 4 cases with 3+ CD68 grade 3 tumors with lymph node metastasis CD68+ macrophages may be associated with worse prognosis PD PD-L1 L.Z. Blanco, Jr., J. Ubago and K.P. Siziopikou: Increased CD68-positive Macrophages and CD4-positive Lymphocytes in Tumor Associated Inflammation correlates in Pregnancy Associated Breast Cancer May Contribute to a Poor Prognosis. Modern Pathology, 28:36A, L.Z. Blanco, Jr., J. Pincus and K.P. Siziopikou: PD-L1 is highly expressed in tumor infiltrating lymphocytes in pregnancy associated breast cancer. San Antonio Breast Cancer Symposium Poster Discusssion in Issues and Challenges for Young Women with Breast Cancer, 2016.

7 Summary PABC is BC diagnosed during or after a recent pregnancy or lactation. PABC affects 25-30% of premenopausal women with breast cancer. Pregnancy results in a transient increase risk in breast cancer followed by a decrease risk (protection) over time. Multiple hypothesis for pregnancy s promoting and protective effects exist. Tissue remodeling during mammary gland involution are similar to wound healing and inflammation and may facilitate tumor progression and metastasis. PABC tends to present at a more advanced stage, with larger, high grade, triple negative or -positive tumors. PABC has worse prognosis compared with age and stage matched controls. Better understanding of the molecular pathways of tumor initiation and progression and prompt diagnosis and treatment in PABC may lead to better OS. Thank you!

Pregnancy and Breast Cancer. Elena Provenzano Addenbrookes Hospital Cambridge

Pregnancy and Breast Cancer. Elena Provenzano Addenbrookes Hospital Cambridge Pregnancy and Breast Cancer Elena Provenzano Addenbrookes Hospital Cambridge Pregnancy and Breast Cancer Pregnancy and Breast Cancer 1. Pregnancy associated breast cancer: Histology, management, clinical

More information

DOCTORAL THESIS SUMMARY

DOCTORAL THESIS SUMMARY UNIVERSITY OF MEDICINE AND PHARMACY CRAIOVA FACULTY OF MEDICINE DOCTORAL THESIS SUMMARY CLINICO-IMAGING STUDY OF INVASIVE DUCTAL BREAST CARCINOMAS CORRELATED TO HORMONAL RECEPTORS AND HER2/NEU ONCOPROTEIN

More information

Breast Imaging: Multidisciplinary Approach. Madelene Lewis, MD Assistant Professor Associate Program Director Medical University of South Carolina

Breast Imaging: Multidisciplinary Approach. Madelene Lewis, MD Assistant Professor Associate Program Director Medical University of South Carolina Breast Imaging: Multidisciplinary Approach Madelene Lewis, MD Assistant Professor Associate Program Director Medical University of South Carolina No Disclosures Objectives Discuss a multidisciplinary breast

More information

Breast Cancer. Most common cancer among women in the US. 2nd leading cause of death in women. Mortality rates though have declined

Breast Cancer. Most common cancer among women in the US. 2nd leading cause of death in women. Mortality rates though have declined Breast Cancer Most common cancer among women in the US 2nd leading cause of death in women Mortality rates though have declined 1 in 8 women will develop breast cancer Breast Cancer Breast cancer increases

More information

Breast Cancer. Saima Saeed MD

Breast Cancer. Saima Saeed MD Breast Cancer Saima Saeed MD Breast Cancer Most common cancer among women in the US 2nd leading cause of death in women 1 in 8 women will develop breast cancer Incidence/mortality rates have declined Breast

More information

Claudin-4 Expression in Triple Negative Breast Cancer: Correlation with Androgen Receptors and Ki-67 Expression

Claudin-4 Expression in Triple Negative Breast Cancer: Correlation with Androgen Receptors and Ki-67 Expression Claudin-4 Expression in Triple Negative Breast Cancer: Correlation with Androgen Receptors and Ki-67 Expression Mona A. Abd-Elazeem, Marwa A. Abd- Elazeem Pathology department, Faculty of Medicine, Tanta

More information

Research Article Stromal Expression of CD10 in Invasive Breast Carcinoma and Its Correlation with ER, PR, HER2-neu, and Ki67

Research Article Stromal Expression of CD10 in Invasive Breast Carcinoma and Its Correlation with ER, PR, HER2-neu, and Ki67 SAGE-Hindawi Access to Research International Breast Cancer Volume 20, Article ID 47957, 4 pages doi:0.406/20/47957 Research Article Stromal Expression of CD0 in Invasive Breast Carcinoma and Its Correlation

More information

Breast cancer staging update. Ekaterini Tsiapali, MD, FACS MedStar Regional Breast Program Site Director

Breast cancer staging update. Ekaterini Tsiapali, MD, FACS MedStar Regional Breast Program Site Director Breast cancer staging update Ekaterini Tsiapali, MD, FACS MedStar Regional Breast Program Site Director 1 1 Review of the AJCC 8 th edition breast cancer staging Review of genomic assays as stage modifiers

More information

Basement membrane in lobule.

Basement membrane in lobule. Bahram Memar, MD Basement membrane in lobule. Normal lobule-luteal phase Normal lobule-follicular phase Lactating breast Greater than 95% are adenocarcinomas in situ carcinomas and invasive carcinomas.

More information

Breast cancer in elderly patients (70 years and older): The University of Tennessee Medical Center at Knoxville 10 year experience

Breast cancer in elderly patients (70 years and older): The University of Tennessee Medical Center at Knoxville 10 year experience Breast cancer in elderly patients (70 years and older): The University of Tennessee Medical Center at Knoxville 10 year experience Curzon M, Curzon C, Heidel RE, Desai P, McLoughlin J, Panella T, Bell

More information

Maram Abdaljaleel, MD Dermatopathologist and Neuropathologist University of Jordan, School of Medicine

Maram Abdaljaleel, MD Dermatopathologist and Neuropathologist University of Jordan, School of Medicine Maram Abdaljaleel, MD Dermatopathologist and Neuropathologist University of Jordan, School of Medicine The most common non-skin malignancy of women 2 nd most common cause of cancer deaths in women, following

More information

Triple Negative Breast Cancer

Triple Negative Breast Cancer Triple Negative Breast Cancer Prof. Dr. Pornchai O-charoenrat Division of Head-Neck & Breast Surgery Department of Surgery Faculty of Medicine Siriraj Hospital Breast Cancer Classification Traditional

More information

Contents 1 The Windows of Susceptibility to Breast Cancer 2 The So Called Pre-Neoplastic Lesions and Carcinoma In Situ

Contents 1 The Windows of Susceptibility to Breast Cancer 2 The So Called Pre-Neoplastic Lesions and Carcinoma In Situ Contents 1 The Windows of Susceptibility to Breast Cancer... 1 1.1 Introduction... 1 1.2 Risk Factor and Etiological Agents... 2 1.3 The Concept of the Windows of Susceptibility to Carcinogenesis... 5

More information

Mousa. Israa Ayed. Abdullah AlZibdeh. 0 P a g e

Mousa. Israa Ayed. Abdullah AlZibdeh. 0 P a g e 1 Mousa Israa Ayed Abdullah AlZibdeh 0 P a g e Breast pathology The basic histological units of the breast are called lobules, which are composed of glandular epithelial cells (luminal cells) resting on

More information

BREAST PATHOLOGY. Fibrocystic Changes

BREAST PATHOLOGY. Fibrocystic Changes BREAST PATHOLOGY Lesions of the breast are very common, and they present as palpable, sometimes painful, nodules or masses. Most of these lesions are benign. Breast cancer is the 2 nd most common cause

More information

Triple Negative Breast Cancer: Clinical Presentation and Multimodality Imaging Characteristics

Triple Negative Breast Cancer: Clinical Presentation and Multimodality Imaging Characteristics Triple Negative Breast Cancer: Clinical Presentation and Multimodality Imaging Characteristics Poster No.: R-0141 Congress: RANZCR-AOCR 2012 Type: Scientific Exhibit Authors: O. H. Woo, S. Jang, K. R.

More information

Recent advances in breast cancers

Recent advances in breast cancers Recent advances in breast cancers Breast cancer is a hetrogenous disease due to distinct genetic alterations. Similar morphological subtypes show variation in clinical behaviour especially in response

More information

ANNEX 1 OBJECTIVES. At the completion of the training period, the fellow should be able to:

ANNEX 1 OBJECTIVES. At the completion of the training period, the fellow should be able to: 1 ANNEX 1 OBJECTIVES At the completion of the training period, the fellow should be able to: 1. Breast Surgery Evaluate and manage common benign and malignant breast conditions. Assess the indications

More information

Contemporary Classification of Breast Cancer

Contemporary Classification of Breast Cancer Contemporary Classification of Breast Cancer Laura C. Collins, M.D. Vice Chair of Anatomic Pathology Professor of Pathology Beth Israel Deaconess Medical Center and Harvard Medical School Boston, MA Outline

More information

3/28/2017. Disclosure of Relevant Financial Relationships. GU Evening Subspecialty Case Conference. Differential Diagnosis:

3/28/2017. Disclosure of Relevant Financial Relationships. GU Evening Subspecialty Case Conference. Differential Diagnosis: GU Evening Subspecialty Case Conference Rajal B. Shah, M.D. VP, Medical Director, Urologic Pathology Miraca Life Sciences, Irving, Texas Clinical Associate Professor of Pathology Baylor College of Medicine,

More information

Case Scenario 1: This case has been slightly modified from the case presented during the live session to add clarity.

Case Scenario 1: This case has been slightly modified from the case presented during the live session to add clarity. Case Scenario 1: This case has been slightly modified from the case presented during the live session to add clarity. Background: 46 year old married premenopausal female with dense breasts has noticed

More information

3/27/2017. Disclosure of Relevant Financial Relationships. Papilloma???

3/27/2017. Disclosure of Relevant Financial Relationships. Papilloma??? Management of Papillary Lesions Diagnosed at Rad Path Concordant Core Biopsy (CNB) Disclosure of Relevant Financial Relationships USCAP requires that all planners (Education Committee) in a position to

More information

BREAST SURGERY PROGRESS TEST Name:

BREAST SURGERY PROGRESS TEST Name: General Surgery Residency Program Excellent surgeons BREAST SURGERY PROGRESS TEST Name: Choose the BEST answer for the following questions. 1. All of the following factors are associated with an increased

More information

Case Scenario 1: This case has been slightly modified from the case presented during the live session to add clarity.

Case Scenario 1: This case has been slightly modified from the case presented during the live session to add clarity. Case Scenario 1: This case has been slightly modified from the case presented during the live session to add clarity. Background: 46 year old married premenopausal female with dense breasts has noticed

More information

Case Scenario 1 History and Physical 3/15/13 Imaging Pathology

Case Scenario 1 History and Physical 3/15/13 Imaging Pathology Case Scenario 1 History and Physical 3/15/13 The patient is an 84 year old white female who presented with an abnormal mammogram. The patient has a five year history of refractory anemia with ringed sideroblasts

More information

Benign, Reactive and Inflammatory Lesions of the Breast

Benign, Reactive and Inflammatory Lesions of the Breast Benign, Reactive and Inflammatory Lesions of the Breast Marilin Rosa, MD Associate Member Section Head of Breast Pathology Department of Anatomic Pathology Program Director, Breast Pathology Fellowship

More information

Implications of Progesterone Receptor Status for the Biology and Prognosis of Breast Cancers

Implications of Progesterone Receptor Status for the Biology and Prognosis of Breast Cancers 日大医誌 75 (1): 10 15 (2016) 10 Original Article Implications of Progesterone Receptor Status for the Biology and Prognosis of Breast Cancers Naotaka Uchida 1), Yasuki Matsui 1), Takeshi Notsu 1) and Manabu

More information

Prognostic significance of stroma tumorinfiltrating lymphocytes according to molecular subtypes of breast cancer

Prognostic significance of stroma tumorinfiltrating lymphocytes according to molecular subtypes of breast cancer Prognostic significance of stroma tumorinfiltrating lymphocytes according to molecular subtypes of breast cancer Hee Jung Kwon, Nuri Jang, Min Hui Park, Young Kyung Bae Department of Pathology, Yeungnam

More information

Question 1 A. ER-, PR-, HER+ B. ER+, PR+, HER2- C. ER-, PR+, HER2- D. ER-, PR-, HER2- E. ER-, PR+, HER2+

Question 1 A. ER-, PR-, HER+ B. ER+, PR+, HER2- C. ER-, PR+, HER2- D. ER-, PR-, HER2- E. ER-, PR+, HER2+ Triple Negative Breast Cancer Laura C. Collins, M.D. Department of Pathology Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, MA Question 1 The tumor depicted on the next slide

More information

Case Scenario 1. 2/15/2011 The patient received IMRT 45 Gy at 1.8 Gy per fraction for 25 fractions.

Case Scenario 1. 2/15/2011 The patient received IMRT 45 Gy at 1.8 Gy per fraction for 25 fractions. Case Scenario 1 1/3/11 A 57 year old white female presents for her annual mammogram and is found to have a suspicious area of calcification, spread out over at least 4 centimeters. She is scheduled to

More information

SFMC Breast Cancer Site Study: 2011

SFMC Breast Cancer Site Study: 2011 SFMC Breast Cancer Site Study: 2011 Introduction Breast cancer is the most frequently diagnosed cancer among American women, except for skin cancers. It is the second leading cause of cancer death in women,

More information

Case #1: 75 y/o Male (treated and followed by prostate cancer oncology specialist ).

Case #1: 75 y/o Male (treated and followed by prostate cancer oncology specialist ). SOLID TUMORS WORKSHOP Cases for review Prostate Cancer Case #1: 75 y/o Male (treated and followed by prostate cancer oncology specialist ). January 2009 PSA 4.4, 20% free; August 2009 PSA 5.2; Sept 2009

More information

Triple-negative breast cancer: which typical features can we identify on conventional and MRI imaging?

Triple-negative breast cancer: which typical features can we identify on conventional and MRI imaging? Triple-negative breast cancer: which typical features can we identify on conventional and MRI imaging? Poster No.: C-1862 Congress: ECR 2013 Type: Educational Exhibit Authors: V. Bertani 1, A. Gualano

More information

OPTO-ACOUSTIC BREAST IMAGING

OPTO-ACOUSTIC BREAST IMAGING OPTO-ACOUSTIC BREAST IMAGING A Novel Fusion of Functional and Morphologic Imaging Reni S. Butler, MD A. Thomas Stavros, MD F. Lee Tucker, MD Michael J. Ulissey, MD PURPOSE 1. Explain opto-acoustic (OA)

More information

Diseases of the breast (1 of 2)

Diseases of the breast (1 of 2) Diseases of the breast (1 of 2) Introduction A histology introduction Normal ducts and lobules of the breast are lined by two layers of cells a layer of luminal cells overlying a second layer of myoepithelial

More information

What I Learned from 3 Cases and 3 Antibodies

What I Learned from 3 Cases and 3 Antibodies What I Learned from 3 Cases and 3 Antibodies Melinda Sanders, M.D Vanderbilt University Medical Center Professor of Pathology Consultant in Breast Pathology Disclosure of Relevant Financial Relationships

More information

Pathology Report Patient Companion Guide

Pathology Report Patient Companion Guide Pathology Report Patient Companion Guide Breast Cancer - Understanding Your Pathology Report Pathology Reports can be overwhelming. They contain scientific terms that are unfamiliar and might be a bit

More information

Only Estrogen receptor positive is not enough to predict the prognosis of breast cancer

Only Estrogen receptor positive is not enough to predict the prognosis of breast cancer Young Investigator Award, Global Breast Cancer Conference 2018 Only Estrogen receptor positive is not enough to predict the prognosis of breast cancer ㅑ Running head: Revisiting estrogen positive tumors

More information

TITLE: DOES LACTATION MITIGATE TRIPLE NEGATIVE/BASAL BREAST CANCER PROGRESSION?

TITLE: DOES LACTATION MITIGATE TRIPLE NEGATIVE/BASAL BREAST CANCER PROGRESSION? AD Award Number: W81XWH-10-1-0679 TITLE: DOES LACTATION MITIGATE TRIPLE NEGATIVE/BASAL BREAST CANCER PROGRESSION? PRINCIPAL INVESTIGATOR: Tanya Russell, Ph.D. CONTRACTING ORGANIZATION: University of Colorado

More information

Types of Breast Cancer

Types of Breast Cancer IOWA RADIOLOGY 1 Types of Breast Cancer 515-226-9810 Ankeny Clive Downtown Des Moines IOWA RADIOLOGY 1 Table of Contents Introduction... 1 Ductal Carcinoma... 2 Paget s Disease of the Nipple... 8 Lobular

More information

SIGNIFICANT OTHERS. Miscellaneous Benign Breast Conditions

SIGNIFICANT OTHERS. Miscellaneous Benign Breast Conditions SIGNIFICANT OTHERS Miscellaneous Benign Breast Conditions Epworth HealthCare 1 FAT NECROSIS TRAUMATIC Cell rupture Seat-Belt injury Blunt trauma Iatrogenic injury Surgery, Flaps, Radiotherapy Pathology

More information

ACRIN 6666 Therapeutic Surgery Form

ACRIN 6666 Therapeutic Surgery Form S1 ACRIN 6666 Therapeutic Surgery Form 6666 Instructions: Complete a separate S1 form for each separate area of each breast excised with the intent to treat a cancer (e.g. each lumpectomy or mastectomy).

More information

Discussing Fertility Preservation with Breast Cancer Patients

Discussing Fertility Preservation with Breast Cancer Patients Chapter 35 Discussing Fertility Preservation with Breast Cancer Patients Jacqueline S. Jeruss J.S. Jeruss (B) Department of Surgery, Robert H. Lurie Comprehensive Cancer Center, Northwestern University

More information

Watchful Waiting: Well Behaved Breast Cancers Non-Surgical Management of Breast Cancer

Watchful Waiting: Well Behaved Breast Cancers Non-Surgical Management of Breast Cancer Case Report imedpub Journals http://www.imedpub.com Journal of Adenocarcinoma DOI: 10.21767/2572-309X.10002 Watchful Waiting: Well Behaved Breast Cancers Non-Surgical Management of Breast Cancer Received:

More information

Breast Cancer. Excess Estrogen Exposure. Alcohol use + Pytoestrogens? Abortion. Infertility treatment?

Breast Cancer. Excess Estrogen Exposure. Alcohol use + Pytoestrogens? Abortion. Infertility treatment? Breast Cancer Breast Cancer Excess Estrogen Exposure Nulliparity or late pregnancy + Early menarche + Late menopause + Cystic ovarian disease + External estrogens exposure + Breast Cancer Excess Estrogen

More information

PAAF vs Core Biopsy en Lesiones Mamarias Case #1

PAAF vs Core Biopsy en Lesiones Mamarias Case #1 5/19/2014 PAAF vs Core Biopsy en Lesiones Mamarias Case #1 Fine Needle Aspiration Cytology of Breast: Correlation with Needle Core Biopsy 64-year-old woman Mass in breast Syed Hoda, MD CD31 Post-Radiation

More information

Index. Note: Page numbers of article titles are in boldface type.

Index. Note: Page numbers of article titles are in boldface type. Note: Page numbers of article titles are in boldface type. A Adjuvant therapy, for early-stage triple-negative breast cancer, 740 742 in older early-stage breast cancer patients, 790 795 anti-her2-directed

More information

57th Annual HSCP Spring Symposium 4/16/2016

57th Annual HSCP Spring Symposium 4/16/2016 An Unusual Malignant Spindle Cell Lesion to Involve the Breast Erinn Downs-Kelly, D.O. Associate Professor of Pathology University of Utah & ARUP Laboratories No disclosures Case 39 y/o female with no

More information

Lesion Imaging Characteristics Mass, Favoring Benign Circumscribed Margins Intramammary Lymph Node

Lesion Imaging Characteristics Mass, Favoring Benign Circumscribed Margins Intramammary Lymph Node Lesion Imaging Characteristics Mass, Favoring Benign Circumscribed Margins Intramammary Lymph Node Oil Cyst Mass, Intermediate Concern Microlobulated Margins Obscured Margins Mass, Favoring Malignant Indistinct

More information

Pathology: Grade 1 infiltrating ductal carcinoma with associated DCIS, Lymphvascular invasion present. ER+, PR+. Her 2/ IHC 1+, negative

Pathology: Grade 1 infiltrating ductal carcinoma with associated DCIS, Lymphvascular invasion present. ER+, PR+. Her 2/ IHC 1+, negative GATRA 2016 Breast Case Demographics Name: Autumn Leaf Sex: F Date of Birth: 3/26/75 SSN: 098765432 Race: African American Marital Status: Single Address: 3615 Burnt Hickory Trail, Helen, GA 37285, White

More information

Cancers of unknown primary : Knowing the unknown. Prof. Ahmed Hossain Professor of Medicine SSMC

Cancers of unknown primary : Knowing the unknown. Prof. Ahmed Hossain Professor of Medicine SSMC Cancers of unknown primary : Knowing the unknown Prof. Ahmed Hossain Professor of Medicine SSMC Definition Cancers of unknown primary site (CUPs) Represent a heterogeneous group of metastatic tumours,

More information

Post Neoadjuvant therapy: issues in interpretation

Post Neoadjuvant therapy: issues in interpretation Post Neoadjuvant therapy: issues in interpretation Disclosure: Overview D Prognostic features in assessment of post treatment specimens: Tumor size Cellularity Grade Receptors LN Neoadjuvant chemotherapy:

More information

Breast Cancer in Young Women Arrow Project June 6 th Aharona Gutman Dr. Shani Paluch-Shimon

Breast Cancer in Young Women Arrow Project June 6 th Aharona Gutman Dr. Shani Paluch-Shimon Breast Cancer in Young Women Arrow Project June 6 th 2013 Aharona Gutman Dr. Shani Paluch-Shimon Overview - Breast Cancer in Young Women 10% of breast cancers are diagnosed in women under 40 Breast cancer

More information

A712(19)- Test slide, Breast cancer tissues with corresponding normal tissues

A712(19)- Test slide, Breast cancer tissues with corresponding normal tissues A712(19)- Test slide, Breast cancer tissues with corresponding normal tissues (formalin fixed) For research use only Specifications: No. of cases: 12 Tissue type: Breast cancer tissues with corresponding

More information

LYMPHATIC DRAINAGE AXILLARY (MOSTLY) INTERNAL MAMMARY SUPRACLAVICULAR

LYMPHATIC DRAINAGE AXILLARY (MOSTLY) INTERNAL MAMMARY SUPRACLAVICULAR BREAST LYMPHATIC DRAINAGE AXILLARY (MOSTLY) INTERNAL MAMMARY SUPRACLAVICULAR HISTOLOGY LOBE: (10 in whole breast) LOBULE: (many per lobe) ACINUS/I, aka ALVEOLUS/I: (many per lobule) DUCT(S): INTRA- or

More information

Breast Cancer Diagnosis, Treatment and Follow-up

Breast Cancer Diagnosis, Treatment and Follow-up Breast Cancer Diagnosis, Treatment and Follow-up What is breast cancer? Each of the body s organs, including the breast, is made up of many types of cells. Normally, healthy cells grow and divide to produce

More information

3/23/2017. Disclosure of Relevant Financial Relationships. Pathologic Staging Updates in Breast Cancer. Pathologic Staging Updates Breast Cancer

3/23/2017. Disclosure of Relevant Financial Relationships. Pathologic Staging Updates in Breast Cancer. Pathologic Staging Updates Breast Cancer Pathologic Staging Updates in Breast Cancer Disclosure of Relevant Financial Relationships USCAP requires that all planners (Education Committee) in a position to influence or control the content of CME

More information

Cairo/EG, Khartoum/SD, London/UK Biological effects, Diagnostic procedure, Ultrasound, Mammography, Breast /ecr2015/C-0107

Cairo/EG, Khartoum/SD, London/UK Biological effects, Diagnostic procedure, Ultrasound, Mammography, Breast /ecr2015/C-0107 Role of sono-mammography in the evaluation of clinically palapble breast masses during pregnancy & lactation with differentaition between true patholgical & false physiological lobular hyperlpasia.sudanese

More information

COPE Library Sample

COPE Library Sample Breast Anatomy LOBULE LOBE ACINI (MILK PRODUCING UNITS) NIPPLE AREOLA COMPLEX ENLARGEMENT OF DUCT AND LOBE LOBULE SUPRACLAVICULAR NODES INFRACLAVICULAR NODES DUCT DUCT ACINI (MILK PRODUCING UNITS) 8420

More information

Clinicopathological Factors Affecting Distant Metastasis Following Loco-Regional Recurrence of breast cancer. Cheol Min Kang 2018/04/05

Clinicopathological Factors Affecting Distant Metastasis Following Loco-Regional Recurrence of breast cancer. Cheol Min Kang 2018/04/05 Abstract No.: ABS-0075 Clinicopathological Factors Affecting Distant Metastasis Following Loco-Regional Recurrence of breast cancer 2018/04/05 Cheol Min Kang Department of surgery, University of Ulsan

More information

ACCME/Disclosures. Case History 4/13/2016. USCAP GU Specialty Conference Case 3. Ann Arbor, MI

ACCME/Disclosures. Case History 4/13/2016. USCAP GU Specialty Conference Case 3. Ann Arbor, MI USCAP GU Specialty Conference Case 3 March 2016 L. Priya Kunju, M.D. University of Michigan Health System Ann Arbor, MI University of Michigan Health System ACCME/Disclosures The USCAP requires that anyone

More information

3/27/2017. Pulmonary Pathology Specialty Conference. Disclosure of Relevant Financial Relationships. Clinical History:

3/27/2017. Pulmonary Pathology Specialty Conference. Disclosure of Relevant Financial Relationships. Clinical History: Pulmonary Pathology Specialty Conference Saul Suster, M.D. Medical College of Wisconsin Disclosure of Relevant Financial Relationships USCAP requires that all planners (Education Committee) in a position

More information

Breast Cancer? Breast cancer is the most common. What s New in. Janet s Case

Breast Cancer? Breast cancer is the most common. What s New in. Janet s Case Focus on CME at The University of Calgary What s New in Breast Cancer? Theresa Trotter, MD, FRCPC Breast cancer is the most common malignancy affecting women in Canada, accounting for almost a third of

More information

Elena Martinez, PhD & Bernard Futscher, PhD (co-pis) University of Arizona Arizona Cancer Center 1U01CA153086

Elena Martinez, PhD & Bernard Futscher, PhD (co-pis) University of Arizona Arizona Cancer Center 1U01CA153086 Elena Martinez, PhD & Bernard Futscher, PhD (co-pis) University of Arizona Arizona Cancer Center 1U01CA153086 Hispanic population in U.S. is largely underserved and underrepresented in research studies

More information

Presented by: Lillian Erdahl, MD

Presented by: Lillian Erdahl, MD Presented by: Lillian Erdahl, MD Learning Objectives What is Breast Cancer Types of Breast Cancer Risk Factors Warning Signs Diagnosis Treatment Options Prognosis What is Breast Cancer? A disease that

More information

Breast pathology. 2nd Department of Pathology Semmelweis University

Breast pathology. 2nd Department of Pathology Semmelweis University Breast pathology 2nd Department of Pathology Semmelweis University Breast pathology - Summary - Benign lesions - Acute mastitis - Plasma cell mastitis / duct ectasia - Fat necrosis - Fibrocystic change/

More information

International Society of Breast Pathology. Immune Targeting in Breast Cancer. USCAP 2017 Annual Meeting

International Society of Breast Pathology. Immune Targeting in Breast Cancer. USCAP 2017 Annual Meeting International Society of Breast Pathology USCAP 2017 Annual Meeting Immune Targeting in Breast Cancer Ashley Cimino-Mathews, MD Assistant Professor of Pathology and Oncology The Johns Hopkins Hospital

More information

Follow-up Care of Breast Cancer Patients

Follow-up Care of Breast Cancer Patients Follow-up Care of Breast Cancer Patients Dr. Simon D. Baxter, MD, FRCPC Medical Oncologist BC Cancer Kelowna Clinical Instructor, Dept of Medicine University of British Columbia 24 November 2018 Disclosures

More information

Immunohistochemical classification of breast tumours

Immunohistochemical classification of breast tumours Immunohistochemical classification of breast tumours Workshop in Diagnostic Immunohistochemistry September 19 th - 21 th 2018 Anne-Vibeke Lænkholm Department of Surgical Pathology, Zealand University Hospital,

More information

Proliferative Breast Disease: implications of core biopsy diagnosis. Proliferative Breast Disease

Proliferative Breast Disease: implications of core biopsy diagnosis. Proliferative Breast Disease Proliferative Breast Disease: implications of core biopsy diagnosis Jean F. Simpson, M.D. Breast Pathology Consultants, Inc. Nashville, TN Proliferative Breast Disease Must be interpreted in clinical and

More information

Primary squamous cell carcinoma of the breast: a rare entity, representation of two cases

Primary squamous cell carcinoma of the breast: a rare entity, representation of two cases International Surgery Journal Siripurapu Y et al. Int Surg J. 2017 Aug;4(8):2848-2853 http://www.ijsurgery.com pissn 2349-3305 eissn 2349-2902 Case Report DOI: http://dx.doi.org/10.18203/2349-2902.isj20173434

More information

Interpretation of Breast Pathology in the Era of Minimally Invasive Procedures

Interpretation of Breast Pathology in the Era of Minimally Invasive Procedures Shahla Masood, M.D. Professor and Chair Department of Pathology and Laboratory Medicine University of Florida College of Medicine Jacksonville Medical Director, UF Health Breast Center Chief of Pathology

More information

Advances in Breast Surgery. Catherine Campo, D.O. Breast Surgeon Meridian Health System April 17, 2015

Advances in Breast Surgery. Catherine Campo, D.O. Breast Surgeon Meridian Health System April 17, 2015 Advances in Breast Surgery Catherine Campo, D.O. Breast Surgeon Meridian Health System April 17, 2015 Objectives Understand the surgical treatment of breast cancer Be able to determine when a lumpectomy

More information

IBCM 2, April 2009, Sarajevo, Bosnia and Herzegovina

IBCM 2, April 2009, Sarajevo, Bosnia and Herzegovina Preoperative diagnosis and treatment planning in breast cancer The pathologist s perspective L. Mazzucchelli Istituto Cantonale di Patologia Locarno, Switzerland IBCM 2, 23-25 April 2009, Sarajevo, Bosnia

More information

Treatment options for the precancerous Atypical Breast lesions. Prof. YOUNG-JIN SUH The Catholic University of Korea

Treatment options for the precancerous Atypical Breast lesions. Prof. YOUNG-JIN SUH The Catholic University of Korea Treatment options for the precancerous Atypical Breast lesions Prof. YOUNG-JIN SUH The Catholic University of Korea Not so benign lesions? Imaging abnormalities(10% recall) lead to diagnostic evaluation,

More information

Breast Pathology. Breast Development

Breast Pathology. Breast Development Breast Pathology Lecturer: Hanina Hibshoosh, M.D. Reading: Kumar, Cotran, Robbins, Basic Pathology, 6th Edition, pages 623-635 Breast Development 5th week - thickening of the epidermis - milk line 5th

More information

Biology of Young Breast Cancer and Management in Pregnant Women

Biology of Young Breast Cancer and Management in Pregnant Women 19 th BSMO Annual Meeting 2017 Breast Cancer Task Force Biology of Young Breast Cancer and Management in Pregnant Women Matteo Lambertini, MD ESMO Fellow Institut Jules Bordet, Brussels Diegem, Belgium

More information

A712(18)- Test slide, Breast cancer tissues with corresponding normal tissues

A712(18)- Test slide, Breast cancer tissues with corresponding normal tissues A712(18)- Test slide, Breast cancer tissues with corresponding normal tissues (formalin fixed) For research use only Specifications: No. of cases: 12 Tissue type: Breast cancer tissues with corresponding

More information

STAGE CATEGORY DEFINITIONS

STAGE CATEGORY DEFINITIONS CLINICAL Extent of disease before any treatment y clinical staging completed after neoadjuvant therapy but before subsequent surgery TX Tis Tis (DCIS) Tis (LCIS) Tis (Paget s) T1 T1mi T1a T1b T1c a b c

More information

Margaret Ann Mays, M.D. Clinical Instructor in Radiology Vanderbilt University Medical Center Tennessee Radiological Society February 25, 2017

Margaret Ann Mays, M.D. Clinical Instructor in Radiology Vanderbilt University Medical Center Tennessee Radiological Society February 25, 2017 Breast Imaging in Adolescents and Young Women Margaret Ann Mays, M.D. Clinical Instructor in Radiology Vanderbilt University Medical Center Tennessee Radiological Society February 25, 2017 Disclosures

More information

Q&A. Fabulous Prizes. Collecting Cancer Data: Breast 4/4/13. NAACCR Webinar Series Collecting Cancer Data Breast

Q&A. Fabulous Prizes. Collecting Cancer Data: Breast 4/4/13. NAACCR Webinar Series Collecting Cancer Data Breast Collecting Cancer Data Breast NAACCR 2012 2013 Webinar Series Q&A Please submit all questions concerning webinar content through the Q&A panel. Reminder: If you have participants watching this webinar

More information

Pregnancy in the middle of adjuvant treatment of Her2 positive breast cancer

Pregnancy in the middle of adjuvant treatment of Her2 positive breast cancer ESMO Preceptorship Programme ESMO Preceptorship ADOLESCENTS & YOUNG ADULTS MALIGNANCIES Lugano, Switzerland 11-12 May 2018 Petra Vuković, University Hospital for Tumors, University Hospital Center Sestre

More information

FAQs for UK Pathology Departments

FAQs for UK Pathology Departments FAQs for UK Pathology Departments This is an educational piece written for Healthcare Professionals FAQs for UK Pathology Departments If you would like to discuss any of the listed FAQs further, or have

More information

Diseases of the breast (2 of 2) Breast cancer

Diseases of the breast (2 of 2) Breast cancer Diseases of the breast (2 of 2) Breast cancer Epidemiology & etiology The most common type of cancer & the 2 nd most common cause of cancer death in women 1 of 8 women in USA Affects 7% of women Peak at

More information

Feasibility of Preoperative Axillary Lymph Node Marking with a Clip in Breast Cancer Patients before Neoadjuvant Chemotherapy: A Preliminary Study

Feasibility of Preoperative Axillary Lymph Node Marking with a Clip in Breast Cancer Patients before Neoadjuvant Chemotherapy: A Preliminary Study [ABS-0078] GBCC 2018 Feasibility of Preoperative Axillary Lymph Node Marking with a Clip in Breast Cancer Patients before Neoadjuvant Chemotherapy: A Preliminary Study Eun Young Kim 1, Kwan Ho Lee 1, Yong

More information

Disclosure of Relevant Financial Relationships

Disclosure of Relevant Financial Relationships Squamous entities of the thyroid: Reactive to Neoplastic Michelle D. Williams Associate Professor Dept of Pathology, Head & Neck Section University of Texas MD Anderson Cancer Center Disclosure of Relevant

More information

THE MALE BREAST CARCINOMA: EARLY DETECTION HOPE. Author (s) Supreethi Kohli a, Pragya Garg b

THE MALE BREAST CARCINOMA: EARLY DETECTION HOPE. Author (s) Supreethi Kohli a, Pragya Garg b Case Report ABSTRACT - Male breast cancer is exceptionally rare and accounts for less than 0.25% of male malignancies and approximately 0.5-1% of all breast cancer (both genders). Mammography of the male

More information

Ductal Carcinoma-in-Situ: New Concepts and Controversies

Ductal Carcinoma-in-Situ: New Concepts and Controversies Ductal Carcinoma-in-Situ: New Concepts and Controversies James J. Stark, MD, FACP Medical Director, Cancer Program and Palliative Care Maryview Medical Center Professor of Medicine, EVMS Case Presentation

More information

What is Cancer? Petra Ketterl, MD Medical Oncology and Functional Medicine

What is Cancer? Petra Ketterl, MD Medical Oncology and Functional Medicine What is Cancer? Petra Ketterl, MD Medical Oncology and Functional Medicine What is Cancer? Layman s terms: cancer starts when cells grow out of control (in any place in the body) and crowd out normal cells

More information

Understanding Your Pathology Report

Understanding Your Pathology Report Understanding Your Pathology Report Because every person s breast cancer is unique, it s important to understand the underlying biology of your tumor to personalize your treatment plan. Your physicians

More information

Papillary Lesions of the Breast

Papillary Lesions of the Breast Papillary Lesions of the Breast Laura C. Collins, M.D. Associate Professor of Pathology Associate Director, Division of Anatomic Pathology Beth Israel Deaconess Medical Center and Harvard Medical School

More information

Carcinoma mammario: le istologie non frequenti. Valentina Guarneri Università di Padova IOV-IRCCS

Carcinoma mammario: le istologie non frequenti. Valentina Guarneri Università di Padova IOV-IRCCS Carcinoma mammario: le istologie non frequenti Valentina Guarneri Università di Padova IOV-IRCCS Histological diversity of breast adenocarcinomas Different histological types are defined according to specific

More information

UK Interdisciplinary Breast Cancer Symposium. Should lobular phenotype be considered when deciding treatment? Michael J Kerin

UK Interdisciplinary Breast Cancer Symposium. Should lobular phenotype be considered when deciding treatment? Michael J Kerin UK Interdisciplinary Breast Cancer Symposium Should lobular phenotype be considered when deciding treatment? Michael J Kerin Professor of Surgery National University of Ireland, Galway and Galway University

More information

Paget's Disease of the Breast: Clinical Analysis of 45 Patients

Paget's Disease of the Breast: Clinical Analysis of 45 Patients 236 Paget's Disease of the Breast: Clinical Analysis of 45 Patients Mingfian Yang Hao Long Jiehua He Xi Wang Zeming Xie Department of Thoracic Oncology, Cancer Center of Sun Yat-sen University, Guangzhou

More information

CPC 4 Breast Cancer. Rochelle Harwood, a 35 year old sales assistant, presents to her GP because she has noticed a painless lump in her left breast.

CPC 4 Breast Cancer. Rochelle Harwood, a 35 year old sales assistant, presents to her GP because she has noticed a painless lump in her left breast. CPC 4 Breast Cancer Rochelle Harwood, a 35 year old sales assistant, presents to her GP because she has noticed a painless lump in her left breast. 1. What are the most likely diagnoses of this lump? Fibroadenoma

More information

Breast Pathology in Men: Radiologic-Pathologic Correlation

Breast Pathology in Men: Radiologic-Pathologic Correlation Breast Pathology in Men: Radiologic-Pathologic Correlation Poster No.: C-0243 Congress: ECR 2012 Type: Scientific Exhibit Authors: G. Garrido; Málaga/ES Keywords: Breast, Ultrasound, Mammography, Biopsy,

More information

Breast cancer: IHC classification. Mogens Vyberg Professor of Clinical Pathology Director of NordiQC Aalborg University Hospital, Aalborg, Denmark

Breast cancer: IHC classification. Mogens Vyberg Professor of Clinical Pathology Director of NordiQC Aalborg University Hospital, Aalborg, Denmark Breast cancer: IHC classification Mogens Vyberg Professor of Clinical Pathology Director of NordiQC Aalborg University Hospital, Aalborg, Denmark http://upload.wikimedia.org/wikipedia/commons/1/1a/breast.svg

More information

Clinical and pathological portraits of axillary presentation breast cancer and effects of preoperative systemic therapy

Clinical and pathological portraits of axillary presentation breast cancer and effects of preoperative systemic therapy Case Series Clinical and pathological portraits of axillary presentation breast cancer and effects of preoperative systemic therapy Ling Xu 1*, Fang Li 1,2*, Yinhua Liu 1, Xuening Duan 1, Jingming Ye 1,

More information

Clinical Trials of Proton Therapy for Breast Cancer. Andrew L. Chang, MD 張維安 Study Chair

Clinical Trials of Proton Therapy for Breast Cancer. Andrew L. Chang, MD 張維安 Study Chair Clinical Trials of Proton Therapy for Breast Cancer Andrew L. Chang, MD 張維安 Study Chair AndrewLChangMD@gmail.com Disclosure Proton Center Development Corporation Scripps San Diego Proton Therapy Center

More information

Papillary Lesions of the Breast

Papillary Lesions of the Breast Papillary Lesions of the Breast Texas Society of Pathologists 2013 Laura C. Collins, M.D. Associate Professor of Pathology Associate Director, Division of Anatomic Pathology Beth Israel Deaconess Medical

More information