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1 Tier R=rare C=common Cancer Entity European crude and age adjusted incidence by cancer, years of diagnosis 2000 and 2007 Analisys based on 83 population-based cancer registries * applying the European crude incidence to the EU-28 population at 2008 ** applying the European crude incidence to the EU-28 population at 2014 *** rates age-adjusted to the European standard population Crude incidence rate x 100,000/year 95% confidence interval Estimated new cases at 2008 in EU Estimated new cases at 2014 in EU (28)** Age-adjusted incidence rate x 100,000/year*** 95% confidence interval 1 R EPITHELIAL TUMOURS OF NASAL CAVITY AND SINUSES ,251 2, R Squamous cell carcinoma with variants of nasal cavity and sinuses ,746 1, R Lymphoepithelial carcinoma of nasal cavity and sinuses R Undifferentiated carcinoma of nasal cavity and sinuses R Intestinal type adenocarcinoma of nasal cavity and sinuses R EPITHELIAL TUMOURS OF NASOPHARYNX R Squamous cell carcinoma with variants of nasopharynx R Papillary adenocarcinoma of nasopharynx R EPITHELIAL TUMOURS OF MAJOR SALIVARY GLANDS AND SALIVARY-GLAND TYPE ,962 7, R Epithelial tumours of major salivary glands ,809 4, R Salivary gland type tumours of head and neck ,153 2, C EPITHELIAL TUMOURS OF HYPOPHARYNX AND LARYNX ,681 32, R Squamous cell carcinoma with variants of hypopharynx ,334 6, R Squamous cell carcinoma with variants of larynx ,067 23, R EPITHELIAL TUMOURS OF OROPHARYNX ,616 16, R Squamous cell carcinoma with variants of oropharynx ,593 15, R EPITHELIAL TUMOURS OF ORAL CAVITY AND LIP ,923 24, R Squamous cell carcinoma with variants of oral cavity ,547 17, R Squamous cell carcinoma with variants of lip ,106 5, C EPITHELIAL TUMOURS OF OESOPHAGUS ,082 39, R Squamous cell carcinoma with variants of oesophagus ,802 17, R Adenocarcinoma with variants of oesophagus ,336 16, R Salivary gland type tumours of oesophagus R Undifferentiated carcinoma of oesophagus C EPITHELIAL TUMOURS OF STOMACH ,201 88, C Adenocarcinoma with variants of stomach ,963 71, R Squamous cell carcinoma with variants of stomach R Salivary gland-type tumours of stomach R Undifferentiated carcinoma of stomach ,054 1, R EPITHELIAL TUMOURS OF SMALL INTESTINE ,875 3, R Adenocarcinoma with variants of small intestine ,945 2, R Squamous cell carcinoma with variants of small intestine C EPITHELIAL TUMOUR OF COLON , , C Adenocarcinoma with variants of colon , , R Squamous cell carcinoma with variants of colon R Fibromixoma and low grade mucinous adenocarcinoma of the appendix C EPITHELIAL TUMOURS OF RECTUM ,550 91, C Adenocarcinoma with variants of rectum ,328 83,

2 2 R Squamous cell carcinoma with variants of rectum R EPITHELIAL TUMOURS OF ANAL CANAL ,799 5, R Squamous cell carcinoma with variants of anal canal ,054 4, R Adenocarcinoma with variants of anal canal ,268 1, R Paget's disease of anal canal C EPITHELIAL TUMOURS OF PANCREAS ,635 65, C Adenocarcinoma with variants of pancreas ,849 40, R Squamous cell carcinoma with variants of pancreas R Acinar cell carcinoma of pancreas R Mucinous cystadenocarcinoma of pancreas R Intraductal papillary mucinous carcinoma invasive of pancreas R Solid pseudopapillary carcinoma of pancreas R Serous cystadenocarcinoma of pancreas R Carcinoma with osteoclast-like giant cells of pancreas C EPITHELIAL TUMOURS OF LIVER AND INTRAEPATIC BILE TRACT (IBT) ,545 36, R Hepatocellular carcinoma of Liver and IBT ,119 16, R Hepatocellular carcinoma, fibrolamellar of liver and IBT R Cholangiocarcinoma of IBT ,856 4, R Adenocarcinoma with variants of liver and IBT ,063 2, R Undifferentiated carcinoma of liver and IBT R Squamous cell carcinoma with variants of liver and IBT R Bile duct cystadenocarcinoma of IBT R EPITHELIAL TUMOURS OF GALLBLADDER AND EXTRAHEPATIC BILIARY TRACT (EBT) ,230 22, R Adenocarcinoma with variants of gallbladder ,735 6, R Adenocarcinoma with variants of EBT ,191 7, R Squamous cell carcinoma of gallbladder and EBT R EPITHELIAL TUMOUR OF TRACHEA R Squamous cell carcinoma with variants of trachea R Adenocarcinoma with variants of trachea R Salivary gland type tumours of trachea C EPITHELIAL TUMOUR OF LUNG , , C Squamous cell carcinoma with variants of lung ,579 62, C Adenocarcinoma with variants of lung ,194 59, R Adenosquamous carcinoma of lung ,472 1, R Large cell carcinoma of lung ,075 19, C Poorly differentiated endocrine carcinoma of lung ,575 40, R Salivary gland type tumours of lung R Sarcomatoid carcinoma of lung ,040 1, R EPITHELIAL TUMOURS OF THYMUS R Malignant thymoma R Squamous cell carcinoma of thymus R Undifferentiated carcinoma of thymus R Lymphoepithelial carcinoma of thymus R Adenocarcinoma with variants of thymus C EPITHELIAL TUMOURS OF BREAST , , C Invasive ductal carcinoma of breast , ,

3 2 C Invasive lobular carcinoma of breast ,798 39, R Mammary Paget s disease of breast ,073 2, R Special types of adenocarcinoma of breast ,337 15, R Metaplastic carcinoma of breast R Salivary gland type tumours of breast R Epithelial tumour of male breast ,301 5, C EPITHELIAL TUMOURS OF CORPUS UTERI ,791 57, C Adenocarcinoma with variants of corpus uteri ,689 50, R Squamous cell carcinoma with variants of corpus uteri R Adenoid cystic carcinoma of corpus uteri R Clear cell adenocarcinoma, not otherwise specified of corpus uteri R Serous (papillary) carcinoma of corpus uteri R Mullerian mixed tumour of corpus uteri ,005 2, C EPITHELIAL TUMOURS OF CERVIX UTERI ,408 31, R Squamous cell carcinoma with variants of cervix uteri ,672 24, R Adenocarcinoma with variants of cervix uteri ,553 4, R Undifferentiated carcinoma of cervix uteri R Mullerian mixed tumour of cervix uteri C EPITHELIAL TUMOUR OF OVARY AND FALLOPPIAN TUBE ,929 47, R Adenocarcinoma with variants of ovary ,792 30, R Mucinous adenocarcinoma of ovary ,854 3, R Clear cell adenocarcinoma of ovary ,518 1, R Primary peritoneal serous/papillary carcinoma of ovary R Mullerian mixed tumour of ovary R Adenocarcinoma with variant of falloppian tube R NON EPITHELIAL TUMOURS OF OVARY ,270 1, R Sex cord tumours of ovary R Malignant/Immature teratomas of ovary R Germ cell tumour of ovary R EPITHELIAL TUMOURS OF VULVA AND VAGINA ,883 10, R Squamous cell carcinoma with variants of vulva and vagina ,440 8, R Adenocarcinoma with variants of vulva and vagina R Paget s disease of vulva and vagina R Undifferentiated carcinoma of vulva and vagina R TROPHOBLASTIC TUMOUR OF PLACENTA R Choriocarcinoma of placenta C EPITHELIAL TUMOURS OF PROSTATE , , C Adenocarcinoma with variants of prostate , , R Squamous cell carcinoma with variants of prostate R Infiltrating duct carcinoma of prostate ,576 2, R Transitional cell carcinoma of prostate R Salivary gland type tumours of prostate R TESTICULAR AND PARATESTICULAR CANCERS ,486 16, R Paratesticular adenocarcinoma with variants R Non seminomatous testicular cancer ,336 6, R Seminomatous testicular cancer ,109 9,

4 2 R Spermatocytic seminoma R Teratoma with malignant transformation R Testicular sex cord cancer R EPITHELIAL TUMOURS OF PENIS ,312 3, R Squamous cell carcinoma with variants of penis ,081 3, R Adenocarcinoma with variants of penis C EPITELIAL TUMOURS OF KIDNEY ,589 64, C Renal cell carcinoma with variants ,436 51, R Squamous cell carcinoma spindle cell type of kidney R Squamous cell carcinoma with variants of kidney R EPITHELIAL TUMOURS OF PELVIS AND URETER ,930 8, R Transitional cell carcinoma of pelvis and ureter ,059 7, R Squamous cell carcinoma with variants of pelvis and ureter R Adenocarcinoma with variants of pelvis and ureter R EPITHELIAL TUMOURS OF URETHRA R Transitional cell carcinoma of urethra R Squamous cell carcinoma with variants of urethra R Adenocarcinoma with variants of urethra C EPITHELIAL TUMOURS OF BLADDER ,080 92, C Transitional cell carcinoma of bladder ,481 79, R Squamous cell carcinoma with variants of bladder ,778 1, R Adenocarcinoma with variants of bladder ,486 1, R Salivary gland type tumours of bladder R EPITHELIAL TUMOURS OF EYE AND ADNEXA R Squamous cell carcinoma with variants of eye and adnexa R Adenocarcinoma with variants of eye and adnexa R EPITHELIAL TUMOURS OF MIDDLE EAR R Squamous cell carcinoma with variants middle ear R Adenocarcinoma with variants of middle ear R MALIGNANT MESOTHELIOMA ,718 10, R Mesothelioma of pleura and pericardium ,160 9, R Mesothelioma of peritoneum and tunica vaginalis C MALIGNANT SKIN MELANOMA ,343 71, C Malignant skin melanoma ,343 71, R MALIGNANT MELANOMA OF MUCOSA R Malignant melanoma of mucosa R MALIGNANT MELANOMA OF UVEA ,521 3, R Malignant melanoma of uvea ,521 3, C EPITHELIAL TUMOURS OF SKIN , , C Basal cell carcinoma of skin , , C Squamous cell carcinoma with variants of skin ,456 72, R ADNEXAL CARCINOMA OF SKIN ,496 1, R Adnexal carcinoma of skin ,496 1, R NEUROBLASTOMA AND GANGLIONEUROBLASTOMA R Neuroblastoma e ganglioneuroblastoma R NEPHROBLASTOMA

5 2 R Nephroblastoma R RETINOBLASTOMA R Retinoblastoma R HEPATOBLASTOMA R Heatoblastoma R PLEUROPULMONARY BLASTOMA R Pleuropulmonary blastoma R PANCREATOBLASTOMA R Pancreatoblastoma R OLFACTORY NEUROBLASTOMA R Olfactory neuroblastoma R ODONTOGENIC MALIGNANT TUMOURS R Odontogenic malignant tumours R EXTRAGONADAL GERM CELL TUMOURS R Non seminomatous germ cell tumours R Seminomatous germ cell tumors R Germ cell tumors of Central Nervous System (CNS) R SOFT TISSUE SARCOMA ,574 23, R Soft tissue sarcoma of head and neck ,306 1, R Soft tissue sarcoma of limbs ,487 5, R Soft tissue sarcoma of superficial trunk ,496 2, R Soft tissue sarcoma of mediastinum R Soft tissue sarcoma of heart R Soft tissue sarcoma of breast R Soft tissue sarcoma of uterus ,765 2, R Other soft tissue sarcomas of genitourinary tract ,009 1, R Soft tissue sarcoma of viscera ,918 1, R Soft tissue sarcoma of paratestis R Soft tissue sarcoma of retroperitoneum and peritoneum ,569 1, R Soft tissue sarcoma of pelvis , R Soft tissue sarcoma of skin ,513 1, R Soft tissue sarcoma of paraorbit R Soft tissue sarcoma of brain and other parts of nervous system R Embryonal rhabdomyosarcoma of soft tissue R Alveolar rhabdomyosarcoma of soft tissue R Ewing s sarcoma of soft tissue R BONE SARCOMA ,273 4, R Osteogenic sarcoma ,064 1, R Chondrogenic sarcomas ,312 1, R Notochordal sarcomas, chordoma R Vascular sarcomas R Ewing s sarcoma R Epithelial tumours, adamantinoma R Other high grade sarcomas (fibrosarcoma, malignant fibrous histiocytoma) R GASTROINTESTINAL STROMAL SARCOMA ,503 1, R Gastrointestinal stromal sarcoma ,503 1,

6 1 R KAPOSI'S SARCOMA ,244 1, R Kaposi's sarcoma ,244 1, R NEUROENDOCRINE TUMOURS ,551 17, R Well differentiated not functing endocrine carcinoma of pancreas and digestive system ,064 5, R Well differentiated functing endocrine carcinoma of pancreas and digestive system R Poorly differentiated endocrine carcinoma of pancreas and digestive system ,329 3, R Mixed endocrine-exocrine carcinoma of pancreas and digestive system R Endocrine carcinoma of thyroid gland ,213 1, R Neuroendocrine carcinoma of skin R Typical and atypical carcinoid of the lung ,968 1, R Neuroendocrine carcinoma of other sites ,511 4, R Pheochromocytoma, malignant R Paraganglioma R CARCINOMAS OF PITUITARY GLAND R Carcinoma of pituitary gland R CARCINOMAS OF THYROID GLAND ,370 25, R Carcinoma of thyroid gland ,370 25, R CARCINOMAS OF PARATHYROID GLAND R Carcinoma of parathyroid gland R CARCINOMA OF ADRENAL GLAND ,094 1, R Carcinoma of adrenal gland ,094 1, C TUMOURS OF CENTRAL NERVOUS SYSTEM (CNS) ,828 37, R Astrocytic tumours of CNS ,954 25, R Oligodendroglial tumours of CNS ,964 1, R Ependymal tumours of CNS ,026 1, R Neuronal and mixed neuronal-glial tumors R Choroid plexus carcinoma of CNS R Malignant meningiomas R EMBRYONAL TUMORS OF CENTRAL NERVOUS SYSTEM (CNS) , R Embryonal tumors of CNS , C LYMPHOID DISEASES , , R Hodgkin lymphoma, classical ,327 12, R Hodgkin lymphoma nodular lymphocyte predominance R Precursor B/T lymphoblastic leuk/lymphoma (and Burkitt leukemia/lymphoma) ,282 7, R T cutaneous lymphoma (Sezary syn, Mycosis fung) ,765 1, R Other T cell lymphomas and NK cell neoplasms ,085 3, R Diffuse B lymphoma ,609 21, R Follicular B lymphoma ,972 11, R Hairy cell leukaemia ,398 1, R Plasmacytoma/Multiple Myeloma (and Heavy chain diseases) ,571 28, C Other non Hodgkin, Mature B cell lymphoma ,858 32, R Mantle cell lymphoma ,794 2, R Prolymphocytic leukaemia, B cell R ACUTE MYELOID LEUKEMIA AND RELATED PRECURSOR NEOPLASMS ,041 19, R Acute promyelocytic leukemia (AML) with t(15;17) with variants R Acute myeloid leukemia ,502 17,

7 1 R MYELOPROLIFERATIVE NEOPLASMS ,575 16, R Chronic myeloid leukemia ,582 5, R Other myeloproliferative neoplasms ,846 10, R Mast cell tumour R MYELODYSPLASTIC SYNDROME AND MYELODYSPLASTIC/MYELOPROLIFERATIVE ,375 12, R Myelodysplastic syndrome with 5q syndrome R Other myelodysplastic syndrome ,715 10, R Chronic Myelomonocytic leukemia ,451 1, R Atypical chronic myeloid leukemia BCR/ABL negative R HISTIOCYTIC AND DENDRITIC CELL NEOPLASMS R Histiocytic malignancies R Lymph node accessory cell tumors

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