QOL Improvements in NETTER-1 Phase III Trial in Patients With Progressive Midgut Neuroendocrine Tumors
|
|
- Charles Randall
- 5 years ago
- Views:
Transcription
1 QOL Improvements in NETTER-1 Phase III Trial in Patients With Progressive Midgut Neuroendocrine Tumors Abstract C-33 Strosberg J, Wolin E, Chasen B, Kulke M, Bushnell D, Caplin M, Baum RP, Kunz P, Hobday T, Hendifar A, Oberg K, Sierra ML, Ruszniewski P, Krenning E
2 NETTER -1 Study Design Aim Evaluate the efficacy and safety of Lu-Dotatate + SSAs (symptoms control) compared to octreotide LAR 60 mg (off-label use) 1 in patients with inoperable, somatostatin receptor positive, midgut NET, progressive under octreotide LAR 30 mg (label use) Design International, multicenter, randomized, comparator-controlled, parallel-group Treatment and Assessments Progression-free survival (RECIST criteria) every 12 weeks Dose 1 Dose 2 Dose 3 Dose 4 n = 115 n = administrations of 7.4 GBq of Lu-Dotatate every 8 weeks + SSAs (symptoms control) Octreotide LAR (high dose - 60mg every 4 weeks1) 5 years follow-up LAR, long-acting release; NET, neuroendocrine tumor; RECIST, response evaluation criteria in solid tumors; SSA, somatostatin analog Strosberg J et al. N Engl J Med (2):
3 NETTER-1 Endpoints and Inclusion Criteria Study Endpoints Primary endpoint Progression-free survival (PFS) Secondary endpoints Response rate Overall survival Safety and tolerability Health-related quality of life (HRQoL) Main Inclusion Criteria Patients >18 years of age Metastatic or locally advanced, inoperable, well-differentiated midgut NET Ki67 index 20% (grade1-2) Progressive disease (RECIST Criteria 1.1 centrally confirmed) on uninterrupted fixed dose of octreotide LAR (20-30 mg) every 3-4 weeks) Somatostatin receptor positive disease Karnofsky Performance Score 60
4 HRQoL Assessment Patients completed the EORTC QLQ C-30 and G.I. NET-21 questionnaires every 12 +/- 1 weeks The questionnaire results were converted to a 100-point scale per the EORTC manual In the QLQ C30 questionnaire, the Global Health Status and five Function Scale (FS) domains are positive scales in which higher scores translate into higher quality of life The symptom scales (SS) are negative scales in which a higher score corresponds to a higher level of symptoms/problems
5 Time to Deterioration (TTD) in HRQoL We present the Quality of Life (QoL) results obtained in the NETTER-1 study comparing treatment with Lu-DOTATATE to octreotide LAR on the time to clinically relevant change (deterioration) in health-related QoL (HRQoL). The method used for this assessment is a time-to-event methodology, where the event is defined as a deterioration in the patient s QoL Time to QoL deterioration (TTD): Time from randomization to the first QoL deterioration 10 points for each patient in the corresponding domain scale For each domain, a Kaplan-Meier plot was produced showing time to event by treatment arm. Kaplan-Meier methods were used to generate a point estimate of the median time to event with corresponding 95% confidence interval (CI) The main analysis was conducted in the population that comprises all randomized patients as per intent to treat (ITT) principles
6 Analysis cut-off date was June 30, 2016 In total, 231 patients were randomized in the study (117 in Lu-Dotatate arm and 114 in the high-dose octreotide LAR arm) HRQoL Assessment Overall compliance rates for patients completing questionnaires were high, with >80% return rates in both arms during the first year
7 Global Health Status Time-to-Deterioration (TTD) How would you rate your overall health during the past week? How would you rate your overall quality of life during the past week? HR 0.40; P =.0006 Lu-Dotatate (12.0;28.8) (0.239;0.691).0006 Octreotide LAR (5.75;22.25)
8 Physical Functioning TTD HR 0.518; P =.0147 Do you have any trouble doing strenuous activities like carrying a heavy shopping bag or suitcase Do you have any trouble taking a long walk Do you have any trouble taking a short walk outside of the house Do you need to stay in bed or a chair during the day Do you need help with eating, drinking, washing yourself or using the toilet Lu-Dotatate (Limits: ;.) (Limits: 0.289; 0.868).0096 Octreotide LAR (Limits: ;.)
9 Role-Functioning TTD Were you limited in doing either your work or other daily activities? Were you limited in pursuing your hobbies or other leisure time activities? HR 0.580; P =.0298 Lu-Dotatate (Limits: 7.12;.) (Limits: 0.353; 0.956).0298 Octreotide LAR (Limits: 8.31; 14.19)
10 Diarrhea TTD Pain TTD HR 0.473; P =.0107 Lu-Dotatate (Limits:. ;.) 0.47 (Limits: 0.263; 0.853).0107 Lu-Dotatate (Limits: ;.) 0.57 (Limits: 0.342; 0.938).0247 Octreotide LAR (Limits: 5.78;.) Octreotide LAR (Limits: ; )
11 Fatigue Flushing/Sweats HR 0.621; P =.0297 Lu-Dotatate Octreotide LAR (Limits: ; ) 5.98 (Limits: ; ) 0.62 (Limits: 0.402; 0.960).0297 Lu-Dotatate Octreotide LAR (Limits: ;.) (Limits: ;.) 0.89 (Limits: 0.517; 1.545).6862
12 Conclusions: The results confirm a statistically significant and robust beneficial effect of Lu-Dotatate on time to deterioration for nearly all clinically relevant parameters In the QoL domains where the improvement of TTD did not reach statistical significance between the arms, it primarily favored the Lu-Dotatate arm Unlike many oncologic drugs, the superior efficacy of Lu- Dotatate is not achieved at the expense of deterioration in QoL, which is not only maintained but improved In conclusion, this analysis demonstrates that Lu-Dotatate provides a significant quality of life benefit for patients with progressive midgut NETs
CLICK TO GO BACK TO KIOSK MENU
Clinical outcomes in patients with baseline renal dysfunction in the NETTER- Study: 77 Lu-DOTATATE vs. high dose octreotide in progressive midgut neuroendocrine tumors J. Strosberg, E. Wolin 2, B. Chasen
More informationHealth-Related Quality of Life in Patients With Progressive Midgut Neuroendocrine Tumors Treated With
VOLUME 36 NUMBER 25 SEPTEMBER 1, 218 JOURNAL OF CLINICAL ONCOLOGY R A P I D C O M M U N I C A T I O N Health-Related Quality of Life in Patients With Progressive Midgut Neuroendocrine Tumors Treated With
More informationThe work of the QoL-Group at EORTC
The work of the QoL-Group at EORTC Francesca Martinelli, MSc EORTC HQ, Brussels, BE 8 th SPAEN Annual Conference February 2-4, 2018 Milan, IT World Cancer Day 2018 (Sunday) Quality of Life (QoL) has been
More informationSession 6: Choosing and using HRQoL measures vs Multi-Attribute Utility Instruments QLU-C10D and EQ-5D as examples
Session 6: Choosing and using HRQoL measures vs Multi-Attribute Utility Instruments QLU-C10D and EQ-5D as examples - Madeleine King & Richard De Abreu Lourenco- Overview Learning Objectives To discuss
More informationNET εντέρου Τι νεότερο/ Νέες μελέτες. Μαντώ Νικολαΐδη παθολόγος-ογκολόγος ΜΗΤΕΡΑ
NET εντέρου Τι νεότερο/ Νέες μελέτες Μαντώ Νικολαΐδη παθολόγος-ογκολόγος ΜΗΤΕΡΑ NET: A Diverse Group of Malignancies 1-3 Wide spectrum of malignancies arising in neuroendocrine cells throughout the body
More informationTeresa Alonso Gordoa Servicio Oncología Médica Hospital Universitario Ramón y Cajal
Teresa Alonso Gordoa Servicio Oncología Médica Hospital Universitario Ramón y Cajal Incidence per 100,000 EPIDEMIOLOGY Incidence rates of neuroendocrine tumors by primary tumor site 1.4 1.2 1.0 0.8 0.6
More informationNeuroendocrine Tumors Positron Emission Tomography (PET) Imaging and Peptide Receptor Radionuclide Therapy
Neuroendocrine Tumors Positron Emission Tomography (PET) Imaging and Peptide Receptor Radionuclide Therapy Lawrence Saperstein, M.D. Assistant Professor of Radiology and Biomedical Imaging Chief, Nuclear
More informationMEDICAL MANAGEMENT OF METASTATIC GEP-NET
MEDICAL MANAGEMENT OF METASTATIC GEP-NET Jeremy Kortmansky, MD Associate Professor of Clinical Medicine Yale Cancer Center DISCLOSURES: NONE Introduction Gastrointestinal and pancreatic neuroendocrine
More informationSession 6 NEW TECHNIQUES IN RADIATION TREATMENT. Chairman : Françoise MORNEX
Session 6 NEW TECHNIQUES IN RADIATION TREATMENT Chairman : Françoise MORNEX INTERNAL IRRADIATION FOR ENDOCRINE TUMORS Emmanuel DESHAYES INTERNAL IRRADIATION FOR ENDOCRINE TUMORS Dr Emmanuel DESHAYES Nuclear
More informationCutting Edge Treatment of Neuroendocrine Tumors
Cutting Edge Treatment of Neuroendocrine Tumors Daneng Li, MD Assistant Clinical Professor Department of Medical Oncology & Therapeutics Research City of Hope Click to edit Master Presentation Date DISCLOSURE
More informationCutting Edge Treatment of Neuroendocrine Tumors
Cutting Edge Treatment of Neuroendocrine Tumors Daneng Li, MD Assistant Clinical Professor Department of Medical Oncology & Therapeutics Research City of Hope Click to edit Master Presentation Date DISCLOSURE
More informationReview of Gastrointestinal Carcinoid Tumors: Latest Therapies
Review of Gastrointestinal Carcinoid Tumors: Latest Therapies Arvind Dasari, MD, MS Department of Gastrointestinal Medical Oncology The University of Texas MD Anderson Cancer Center Houston, TX, USA Neuroendocrine
More informationTumor Growth Rate (TGR) A New Indicator of Antitumor Activity in NETS? IPSEN NET Masterclass Athens, 12 th November 2016
1 Tumor Growth Rate (TGR) A New Indicator of Antitumor Activity in NETS? IPSEN NET Masterclass Athens, 12 th November 2016 Philippe RUSZNIEWSKI ENETS Centre of Excellence, Beaujon Hospital, Clichy, France
More informationPrior Authorization Review Panel MCO Policy Submission
Prior Authorization Review Panel MCO Policy Submission A separate copy of this form must accompany each policy submitted for review. Policies submitted without this form will not be considered for review.
More informationRecent Advances in Gastrointestinal Cancers
Recent Advances in Gastrointestinal Cancers Ursina R. Teitelbaum, MD Section of Hematology/Oncology Abramson Cancer Center PENN 2016 Updates in Oncology June 23, 2016 none Disclosures ASCO 2016 Highlights:
More informationUnderstanding Biological Activity to Inform Drug Development
National Cancer Policy Forum Understanding Biological Activity to Inform Drug Development December 12, 2016 Wolfgang Weber Molecular Imaging and Therapy Service Department of Radiology RECIST Response
More informationNuevas alternativas en el manejo de TNE avanzados
Nuevas alternativas en el manejo de TNE avanzados Jaume Capdevila Hospital Universitari Vall d Hebron Barcelona Coordinación científica: Dr. Fernando Rivera Hospital Universitario Marqués de Valdecilla,
More informationRecent developments of oncology in neuroendocrine tumors (NETs)
Recent developments of oncology in neuroendocrine tumors (NETs) Marc Peeters MD, PhD Coordinator Multidisciplinary Oncological Center Antwerpen (MOCA) Head of the Oncology Department UZA, Professor in
More informationPeptide Receptor Radionuclide Therapy (PRRT) of NET
Peptide Receptor Radionuclide Therapy (PRRT) of NET Dr. Tuba Kendi Associate Prof of Radiology, Mayo Clinic, Rochester, MN 2014 MFMER slide-1 Relevant Financial Relationship(s) None Off Label Usage None
More informationJaume Capdevila, MD GI and Endocrine Tumor Unit Vall d Hebron University Hospital Developmental Therapeutics Unit Vall d Hebron Institute of Oncology
Jaume Capdevila, MD GI and Endocrine Tumor Unit Vall d Hebron University Hospital Developmental Therapeutics Unit Vall d Hebron Institute of Oncology OUTLINE Molecular Rationale for the use of SSAs in
More informationLu 177-Dotatate (Lutathera) Therapy Information
Lu 177-Dotatate (Lutathera) Therapy Information Information for Lu 177-dotatate therapy also known as Lutathera, for the treatment of metastatic midgut neuroendocrine tumor and other metastatic neuroendocrine
More informationTRACTAMENT ONCOLÒGIC DELS TUMORS NEUROENDOCRINS METASTÀSICS
TRACTAMENT ONCOLÒGIC DELS TUMORS NEUROENDOCRINS METASTÀSICS Jaume Capdevila Unitat de Tumors GI i Endocrins Hospital Universitari Vall d Hebron Barcelona Experts, acollidors i solidaris OUTLINE BACKGROUND
More informationHot of the press. Γρηγόριος Καλτσάς MD FRCP Καθηγητής Παθολογίας Ενδοκρινολογίας ΕΚΠΑ
Hot of the press Γρηγόριος Καλτσάς MD FRCP Καθηγητής Παθολογίας Ενδοκρινολογίας ΕΚΠΑ Outline Diagnostic developments Histopathology Molecular Therapeutic developments Results on PRRT Telotristat in carcinoid
More informationEverolimus, lutetium-177 DOTATATE and sunitinib for treating unresectable or metastatic neuroendocrine tumours with disease progression MTA
Everolimus, lutetium-177 DOTATATE and sunitinib for treating unresectable or metastatic neuroendocrine tumours with disease progression MTA 1 st Appraisal Committee meeting Cost Effectiveness Committee
More informationlutetium ( 177 Lu) oxodotreotide 370MBq/mL solution for infusion (Lutathera ) SMC No 1337/18 Advanced Accelerator Applications
lutetium ( 177 Lu) oxodotreotide 370MBq/mL solution for infusion (Lutathera ) SMC No 1337/18 Advanced Accelerator Applications 8 June 2018 The Scottish Medicines Consortium (SMC) has completed its assessment
More informationBodoky G, Gil-Delgado M, Cascinu S, Lipatov ON, Cunningham D, Van Cutsem E, Muro K, Chandrawansa K, Liepa AM, Carlesi R, Ohtsu A, Wilke H
Characterizing Tumor Responses From RAINBOW, a Randomized Phase III Trial of Ramucirumab (RAM) Plus Paclitaxel (PAC) vs Placebo (PBO) Plus PAC in Patients (pts) With Previously Treated Advanced Gastric
More information*Bert Bakker was an employee of Novartis Pharmaceuticals Corporation until June 06, 2014.
Page 1 of 20 Accepted Preprint first posted on 15 September 2015 as Manuscript ERC-15-0314 1 2 Efficacy of Octreotide LAR in Neuroendocrine Tumors: RADIANT-2 Placebo Arm Post Hoc Analysis 3 4 Authors:
More informationOPTIMISING OUTCOMES IN GASTROINTESTINAL NEUROENDOCRINE TUMOURS
OPTIMISING OUTCOMES IN GASTROINTESTINAL NEUROENDOCRINE TUMOURS Dr Mairéad McNamara Senior lecturer, University of Manchester & Honorary Consultant in Medical Oncology, The Christie NHS Foundation Trust
More informationTheragnostics Neuroendocrine and Prostate Cancer
Theragnostics Neuroendocrine and Prostate Cancer Target Audience: Pharmacists ACPE#: 0202-0000-18-080-L01-P Activity Type: Knowledge-based Target Audience: ACPE#: Activity Type: Disclosures Financial:
More informationPeptide Receptor Radiation Therapy (PRRT) in Patients with Neuroendocrine Tumors: The Edmonton Experience
Peptide Receptor Radiation Therapy (PRRT) in Patients with Neuroendocrine Tumors: The Edmonton Experience Sandy McEwan, M.B. F.R.C.P.C Chair, Department of Oncology University of Alberta Disclosures I
More informationAntiangiogenics are effective treatments in NETs
RENET: A randomized phase III trial comparing REgorafenib to placebo in patients with advanced, progressive, well-differentiated NEuroendocrine Tumors (NETs). Coordinators: Dr Julien Hadoux & Dr David
More informationBackground. Capdevila J, et al. Ann Oncol. 2018;29(Suppl 8): Abstract 1307O. 1. Dasari A, et al. JAMA Oncol. 2017;3(10):
Efficacy of Lenvatinib in Patients With Advanced Pancreatic (pannets) and Gastrointestinal (ginets) WHO Grade 1/2 (G1/G2) Neuroendocrine Tumors: Results of the International Phase II TALENT Trial (GETNE
More informationPhase 3 Trial of 177 Lu-Dotatate for Midgut Neuroendocrine Tumors
Original Article Phase 3 Trial of Lu-Dotatate for Midgut Neuroendocrine Tumors J. Strosberg, G. El Haddad, E. Wolin, A. Hendifar, J. Yao, B. Chasen, E. Mittra, P.L. Kunz, M.H. Kulke, H. Jacene, D. Bushnell,
More informationSystematic Review of the Role of Targeted Therapy in Metastatic Neuroendocrine Tumors
At the Cutting Edge Received: February 29, 2016 Accepted: April 12, 2016 Published online: April 16, 2016 Systematic Review of the Role of Targeted Therapy in Metastatic Neuroendocrine Tumors Adrian Lee
More informationWHAT TO EXPECT IN 2015? - Renuka Iyer, MD Associate Professor of Medicine, University at Buffalo Associate Professor of Oncology, Roswell Park Cancer
WHAT TO EXPECT IN 2015? - Renuka Iyer, MD Associate Professor of Medicine, University at Buffalo Associate Professor of Oncology, Roswell Park Cancer Institute Overview Diagnosis: Gallium scan Biomarkers
More informationGEP NET: algoritmo terapeutico. Dottor Nicola Fazio
GEP NET: algoritmo terapeutico Dottor Nicola Fazio Basi per il trattamento Caratteristiche del paziente Caratteristiche del tumore P.S., sindrome, comorbidità Differenziazione, Ki-67 Imaging morfologico
More informationSupplementary Appendix
Supplementary Appendix This appendix has been provided by the authors to give readers additional information about their work. Supplement to: Strosberg J, El-Haddad G, Wolin E, et al. Phase 3 trial of
More informationSelection of Appropriate Treatment
Expert Review in Metastatic Gastroenteropancreatic Neuroendocrine Tumors (GEP-NETs): Selection of Appropriate Treatment Reference Slide Deck Neuroendocrine Tumors (NETs): A Diverse Group of Malignancies
More informationDiscovering Breakthrough Treatments for Human Disease. Discovering Breakthrough Treatments for Human Disease
Patient Reported Outcomes in Oncology Trials Pablo Lapuerta, MD Executive Vice President and Chief Medical Officer Discovering Breakthrough Treatments for Human Disease Discovering Breakthrough Treatments
More informationChair s presentation Lutetium (177lu) oxodotreotide for treating unresectable or metastatic neuroendocrine tumours in people with progressive disease
Public slides Chair s presentation Lutetium (177lu) oxodotreotide for treating unresectable or metastatic neuroendocrine tumours in people with progressive disease 2 nd Appraisal Committee meeting Committee
More informationDoes RT favor RP in long term Quality of Life? Juanita Crook MD FRCPC Professor of Radiation Oncology University of British Columbia
Does RT favor RP in long term Quality of Life? Juanita Crook MD FRCPC Professor of Radiation Oncology University of British Columbia Disclosures Advisory Board/honoraria: Varian Advisory Board: Breast
More informationLe target therapy nei Tumori Neuroendocrini
Le target therapy nei Tumori Neuroendocrini Take home messages Franco Grimaldi SOC Endocrinologia e Malattie del Metabolismo Nutrizione Clinica Azienda Ospedaliero-Universitaria Santa Maria della Misericordia
More informationNET ΠΝΕΥΜΟΝΑ: τι νεότερο / νέες μελέτες
NETMASTERCLASS 2017: an interactive workshop NET ΠΝΕΥΜΟΝΑ: τι νεότερο / νέες μελέτες Νικόλαος Τσουκαλάς MD, MSc, PhD Ογκολόγος - Παθολόγος, MSc Βιοπληροφορική Επιμελητής Α, Ογκολογικό Τμήμα Νοσηλευτικό
More informationstatus should be eligible for treatment with atezolizumab. perc acknowledged the small number of patients with an EGFR or ALK mutation positive disease recruited on the trials but agreed that the overall
More informationOctreotide LAR in neuroendocrine tumours a summary of the experience
Endocrinology in oncology Review article Octreotide LAR in neuroendocrine tumours a summary of the experience Agnieszka Kolasińska-Ćwikła, MD, PhD Department of Chemotherapy, Oncology Clinic, Maria Sklodowska-Curie
More information1 st Appraisal Committee meeting Background & Clinical Effectiveness Gillian Ells & Malcolm Oswald 24/11/2016
Lead team presentation Nivolumab for treating recurrent or metastatic squamous-cell carcinoma of the head and neck after platinum-based chemotherapy [ID971] 1 st Appraisal Committee meeting Background
More informationCase Report. Ameya D. Puranik, MD, FEBNM; Harshad R. Kulkarni, MD; Aviral Singh, MD; Richard P. Baum, MD, PhD ABSTRACT
Case Report 8-YEAR SURVIVAL WITH A METASTATIC THYMIC NEUROENDOCRINE TUMOR: EMPHASIS ON REDEFINING TREATMENT OBJECTIVES USING PERSONALIZED PEPTIDE RECEPTOR RADIONUCLIDE THERAPY WITH 177 Lu- AND 90 Y-LABELED
More information2015: Year in Review Results of Recent Trials
2015: Year in Review Results of Recent Trials Pamela L. Kunz, MD Assistant Professor of Medicine / GI Oncology Director, Stanford NET Program Stanford University School of Medicine Disclosures Research
More informationNovartis Investor Call Highlights from ESMO
Novartis AG Investor Relations Novartis Investor Call Highlights from ESMO Liz Barrett, Oncology CEO Samit Hirawat, Oncology Global Development Head October 22, 2018 Disclaimer This presentation contains
More informationMEET MARY KISQALI PATIENT PROFILES
KISQALI PATIENT PROFILES MEET MARY Mary was recently diagnosed with HR+/HER2- metastatic breast cancer Review the data from the MONALEESA-2 trial to see how patients like Mary responded The patient profile
More informationToward More Aggressive Management of Neuroendocrine Tumors: Current and Future Perspectives
Toward More Aggressive Management of Neuroendocrine Tumors: Current and Future Perspectives Moderator: Ashley Grossman, MD, FRCP Professor of Neuroendocrinology William Harvey Research Institute Barts
More informationINMUNOTERAPIA I. Dra. Virginia Calvo
INMUNOTERAPIA I Dra. Virginia Calvo LBA62. Health-related quality of life (HRQoL) for Pembrolizumab or placebo plus Carboplatin and Paclitaxel or nab-paclitaxel in patients with metastatic squamous NSCLC:
More informationThis clinical study synopsis is provided in line with Boehringer Ingelheim s Policy on Transparency and Publication of Clinical Study Data.
abcd Clinical Study for Public Disclosure This clinical study synopsis is provided in line with s Policy on Transparency and Publication of Clinical Study Data. The synopsis which is part of the clinical
More informationTargeted Therapies in Metastatic Colorectal Cancer: An Update
Targeted Therapies in Metastatic Colorectal Cancer: An Update ASCO 2007: Targeted Therapies in Metastatic Colorectal Cancer: An Update Bevacizumab is effective in combination with XELOX or FOLFOX-4 Bevacizumab
More informationA New Proposal for Metabolic Classification of NENs Stefano Severi IRST Meldola Italy
RADIONUCLIDE THERAPY AND ALLIED SCIENCE President: Giovanni Paganelli Chairman: Maria Salvato Baltimore USA Domenico Barone Meldola Italy A New Proposal for Metabolic Classification of NENs Stefano Severi
More informationThis clinical study synopsis is provided in line with Boehringer Ingelheim s Policy on Transparency and Publication of Clinical Study Data.
abcd Clinical Study for Public Disclosure This clinical study synopsis is provided in line with s Policy on Transparency and Publication of Clinical Study Data. The synopsis which is part of the clinical
More informationEvaluation and Management of Neuroendocrine Tumors
Evaluation and Management of Neuroendocrine Tumors Jennifer Chan, MD, MPH Clinical Director, Program in Neuroendocrine and Carcinoid Tumors Dana-Farber/Brigham and Women's Cancer Center October 14, 2017
More informationNeuroendocrine Tumour Theranostics
Neuroendocrine Tumour Theranostics Lisa Bodei Director of Targeted Radionuclide Therapy Molecular Imaging and Therapy Service Memorial Sloan Kettering Cancer Center New York Friday, April 13, 2018 Disclosure
More informationLutetium-177 PSMA (LuPSMA) Theranostic Phase II trial: Efficacy, safety and QoL in patients
Lutetium-177 PSMA (LuPSMA) Theranostic Phase II trial: Efficacy, safety and QoL in patients with castrate-resistant prostate cancer treated with LuPSMA M. S. Hofman, S. Sandhu, P. Eu, P. Jackson, T. Akhurst,
More informationLung Cancer Patient Outcomes
Lung Cancer Patient Outcomes Dr Neal Navani MA MSc PhD FRCP Consultant Respiratory Physician, UCLH Clinical Senior Lecturer, UCL Lead Clinician for Lung Cancer, UCLH Co-Clinical Lead, NLCA, Royal College
More informationCase 1 Metastatic Pancreatic Adenocarcinoma: What Therapy Should I Select First?
Case 1 Metastatic Pancreatic Adenocarcinoma: What Therapy Should I Select First? Marc Peeters, MD, PhD Head of the Oncology Department Antwerp University Hospital Antwerp, Belgium marc.peeters@uza.be 71-year-old
More information4.3 Input parameters Patient
Table of Content 1 Introduction -------------------------------------------------------------------------------------------------- 7 Summary -----------------------------------------------------------------------------------------------------------
More informationPRO ASSESSMENT IN CANCER TRIALS. Emiliano Calvo, Anita Margulies, Eric Raymond, Ian Tannock, Nadia Harbeck and Lonneke van de Poll-Franse
PRO ASSESSMENT IN CANCER TRIALS Emiliano Calvo, Anita Margulies, Eric Raymond, Ian Tannock, Nadia Harbeck and Lonneke van de Poll-Franse DISCLOSURES Emiliano Calvo has reported no conflicts of interest
More informationEdith A. Perez, Ahmad Awada, Joyce O Shaughnessy, Hope Rugo, Chris Twelves, Seock-Ah Im, Carol Zhao, Ute Hoch, Alison L. Hannah, Javier Cortes
BEACON: A Phase 3 Open-label, Randomized, Multicenter Study of Etirinotecan Pegol (EP) versus Treatment of Physician s Choice (TPC) in Patients With Locally Recurrent or Metastatic Breast Cancer Previously
More informationTUMORES NEUROENDOCRINOS. Miguel Navarro. Salamanca
TUMORES NEUROENDOCRINOS Miguel Navarro. Salamanca Introduction to Neuroendocrine Tumours (NETs) NETs are relatively RARE At least 40 different entities are described arising in different organs. Different
More informationTitle: High Risk of Myelodysplastic Syndrome (MDS) and Acute Myeloid. in Neuroendocrine Tumor Patients Heavily Pre-treated with Alkylating
Page 1 of 12 Accepted Preprint first posted on 1 March 2016 as Manuscript ERC-15-0543 1 2 3 4 Title: High Risk of Myelodysplastic Syndrome (MDS) and Acute Myeloid Leukemia (AML) after 177 Lu-octreotate
More informationTHERAPEUTIC RADIOPHARMACEUTICALS
UnitedHealthcare of California (HMO) UnitedHealthcare Benefits Plan of California (EPO/POS) UnitedHealthcare of Oklahoma, Inc. UnitedHealthcare of Oregon, Inc. UnitedHealthcare Benefits of Texas, Inc.
More informationClinical Roundtable Monograph
Clinical Roundtable Monograph Clinical Advances in Hematology & Oncology April 2017 Recent Advances in the Management of Gastroenteropancreatic Neuroendocrine Tumors: Insights From the 2017 ASCO Gastrointestinal
More informationSIRT in the Management of Metastatic Neuroendocrine Tumors
SIRT in the Management of Metastatic Neuroendocrine Tumors Navesh K. Sharma, DO, PhD Assistant Professor, Departments of Radiation Oncology, Diagnostic Radiology and Nuclear Medicine Medical Director,
More informationLead team presentation Eribulin for treating locally advanced or metastatic breast cancer after two or more prior chemotherapy regimens STA
For projector and public [noacic] Lead team presentation Eribulin for treating locally advanced or metastatic breast cancer after two or more prior chemotherapy regimens STA 1 st Appraisal Committee meeting
More informationQuality-adjusted survival in a crossover trial of letrozole versus tamoxifen in postmenopausal women with advanced breast cancer
Original article Annals of Oncology 16: 1458 1462, 25 doi:1.193/annonc/mdi275 Published online 9 June 25 Quality-adjusted survival in a crossover trial of letrozole versus tamoxifen in postmenopausal women
More informationsunitinib 12.5mg, 25mg, 37.5mg, 50mg hard capsules (Sutent ) SMC No. (698/11) Pfizer Limited
sunitinib 12.5mg, 25mg, 37.5mg, 50mg hard capsules (Sutent ) SMC No. (698/11) Pfizer Limited 08 April 2011 The Scottish Medicines Consortium (SMC) has completed its assessment of the above product and
More informationIncorporating the patient voice in sarcoma research:
Incorporating the patient voice in sarcoma research: How can we assess health-related quality of life in this heterogeneous patient groep? Olga Husson PhD Institute of Cancer Research, Division of Clinical
More informationAdvanced typical and atypical carcinoid tumours of the lung: management recommendations
REVIEW ARTICLE Advanced typical and atypical carcinoid tumours of the lung: management recommendations B. Melosky md* ABSTRACT Background Neuroendocrine tumours (nets) are classified by site of origin,
More informationMedical Policy An independent licensee of the Blue Cross Blue Shield Association
Xermelo (telotristat) Page 1 of 5 Medical Policy An independent licensee of the Blue Cross Blue Shield Association Title: Xermelo (telotristat) Prime Therapeutics will review Prior Authorization requests
More informationRe-Submission. Scottish Medicines Consortium. erlotinib, 100 and 150mg film-coated tablets (Tarceva ) No. 220/05 Roche. 5 May 2006
Scottish Medicines Consortium Re-Submission erlotinib, 100 and 150mg film-coated tablets (Tarceva ) No. 220/05 Roche 5 May 2006 The Scottish Medicines Consortium (SMC) has completed its assessment of the
More informationReDOS Trial Background
Regorafenib Dose Optimization Study (ReDos) A Phase II Randomized Study of Lower Dose Regorafenib Compared to Standard Dose Regorafenib in Patients With Refractory Metastatic Colorectal Cancer (mcrc) Abstract
More informationMedical Policy An independent licensee of the Blue Cross Blue Shield Association
Xermelo (telotristat) Page 1 of 5 Medical Policy An independent licensee of the Blue Cross Blue Shield Association Title: Xermelo (telotristat) Prime Therapeutics will review Prior Authorization requests
More informationPEPTIDE RECEPTOR RADIONUCLIDE THERAPY HOW, WHY AND WHEN
PEPTIDE RECEPTOR RADIONUCLIDE THERAPY HOW, WHY AND WHEN Richard P. Baum, MD, PhD THERANOSTICS Center for Molecular Radiotherapy & Molecular Imaging ENETS Center of Excellence, Zentralklinik Bad Berka,
More informationPRRT in Management of NETs. Ioannis Karfis, MD PhD Assistant Head of Clinic Nuclear Medicine Dept IJB, Brussels
PRRT in Management of NETs Ioannis Karfis, MD PhD Assistant Head of Clinic Nuclear Medicine Dept IJB, Brussels THERAPEUTIC TARGETS in NENs Pavel M: Neuroendocrinology 2013;97:99-112 THERAPEUTIC ARENA in
More informationStudy Period: 27 March 2008 (first subject enrolled) to 05 May 2010 (data cutoff date for primary analysis)
Date: 20 July 2011 Page 2 of 3375 2. SYNOPSIS Name of Sponsor: mgen Inc., Thousand Oaks, C US Name of Finished Product: Not applicable Name of ctive Ingredient: Ganitumab (MG 479) Title of Study: n International,
More informationDevelopment of New Treatment Modalities Oncolytic Viruses and Nanotechnique
Development of New Treatment Modalities Oncolytic Viruses and Nanotechnique By Professor Kjell Öberg, M.D., Ph.D. Dept. of Endocrine Oncology, University Hospital, Uppsala, Sweden Nashville Oct. 2011 Hallmarks
More informationIn Woong Han 1, O Choel Kwon 1, Min Gu Oh 1, Yoo Shin Choi 2, and Seung Eun Lee 2. Departments of Surgery, Dongguk University College of Medicine 2
Effect of Rowachol on Prevention of Postcholecystectomy Syndrome after Laparoscopic Cholecystectomy - Prospective multicenter Randomized controlled trial- In Woong Han 1, O Choel Kwon 1, Min Gu Oh 1, Yoo
More informationNET del pancreas ben differenziato: la terapia oncologica. Alfredo Berru: Università degli Studi di Brescia Azienda Ospedaliera Spedali Civili Brescia
NET del pancreas ben differenziato: la terapia oncologica Alfredo Berru: Università degli Studi di Brescia Azienda Ospedaliera Spedali Civili Brescia Systemic treatment op:ons Somatosta:n analogues Interpheron
More informationDISCLOSURE SLIDE. ARGOS: research funding, scientific advisory board
INTERIM ANALYSIS OF THE PHASE 3 ADAPT TRIAL EVALUATING ROCAPULDENCEL-T (AGS-003), AN INDIVIDUALIZED IMMUNOTHERAPY FOR THE TREATMENT OF NEWLY-DIAGNOSED PATIENTS WITH METASTATIC RENAL CELL CARCINOMA (MRCC)
More informationPembrolizumab for Patients With PD-L1 Positive Advanced Carcinoid or Pancreatic Neuroendocrine Tumors: Results From the KEYNOTE-028 Study
Pembrolizumab for Patients With PD-L1 Positive Advanced Carcinoid or Pancreatic Neuroendocrine Tumors: Results From the KEYNOTE-28 Study Abstract 427O Mehnert JM, Bergsland E, O Neil BH, Santoro A, Schellens
More informationSymptom Benefit Committee. Chicago May 2018 F. Hilpert/JE Kurtz
Symptom Benefit Committee Chicago May 2018 F. Hilpert/JE Kurtz Symptom Benefit Committee Published studies SOLO 2-QoL accepted in Lancet Oncology NOVA-QoL submitted MOST questionnaire Update: ongoing studies
More informationPRESS RELEASE. Advanced Accelerator Applications Receives US FDA Approval for LUTATHERA for Treatment of Gastroenteropancreatic Neuroendocrine Tumors
PRESS RELEASE Advanced Accelerator Applications Receives US FDA Approval for LUTATHERA for Treatment of Gastroenteropancreatic Neuroendocrine Tumors First-in-class Therapy Demonstrated 79% Improvement
More informationEXOCRINE: 93% Acinar Cells Duct Cells. ENDOCRINE: 5% Alpha Cells Beta Cells Delta Cells Others
EXOCRINE: 93% Acinar Cells Duct Cells Digestive Enzymes Trypsin: Digests Proteins Lipases: Digests Fats Amylase: Digest Carbohydrates ENDOCRINE: 5% Alpha Cells Beta Cells Delta Cells Others Hormones Glucagon
More informationOVERVIEW OF THE DIAGNOSIS AND TREATMENT OF GI NETS
OVERVIEW OF THE DIAGNOSIS AND TREATMENT OF GI NETS Dr Christos G. Toumpanakis MD PhD FRCP FEBGH Consultant in Gastroenterology/Neuroendocrine Tumours Hon. Senior Lecturer University College of London Neuroendocrine
More informationPANCREATIC NEUROENDOCRINE TUMORS DECEMBER 12, 2017 IF YOU EXPERIENCE TECHNICAL DIFFICULTY DURING THE PRESENTATION:
PANCREATIC NEUROENDOCRINE TUMORS DECEMBER 12, 2017 IF YOU EXPERIENCE TECHNICAL DIFFICULTY DURING THE PRESENTATION: CONTACT WEBEX TECHNICAL SUPPORT DIRECTLY AT: US TOLL FREE: 1-866-779-3239 TOLL ONLY: 1-408-435-7088
More informationWhat makes Oncology special? Johanna MURSIC, Indication Programmer PhUSE congress Budapest, October 15 th 2012
What makes Oncology special? Johanna MURSIC, Indication Programmer PhUSE congress Budapest, October 15 th 2012 Disclaimer The opinions expressed in this presentation and on the following slides are solely
More informationThese questions are about the physical problems which may have occurred as a result of your stroke. Quite a bit of strength
PhenX Measure: Functionality after Stroke (#820700) PhenX Protocol: Stroke Impact Scale (SIS) - Adults (#820701) Date of Interview/Examination (MM/DD/YYYY): _ Stroke Impact Scale VERSION 3.0 The purpose
More informationJosh is JB s brother and caregiver.
PUT GBM ON PAUSE PUT LIFE ON PLAY Josh is JB s brother and caregiver. JB is an Optune user. OPTUNE + TMZ HAS BEEN PROVEN TO PROVIDE LONG-TERM QUALITY SURVIVAL TO PATIENTS WITH NEWLY DIAGNOSED GBM1,2,*
More informationScottish Medicines Consortium
Scottish Medicines Consortium cetuximab 2mg/ml intravenous infusion (Erbitux ) (279/06) MerckKGaA No 9 June 2006 The Scottish Medicines Consortium (SMC) has completed its assessment of the above product
More informationTherapeutic Radiopharmaceuticals in Oncology
Therapeutic Radiopharmaceuticals in Oncology Policy Number: 6.01.60 Last Review: 9/2018 Origination: 9/2018 Next Review: 9/2019 Policy Blue Cross and Blue Shield of Kansas City (Blue KC) will provide coverage
More informationCRITICAL ANALYSIS OF NEN GUIDELINES. G Pentheroudakis Associate Professsor of Oncology Medical School, University of Ioannina Chair, ESMO Guidelines
CRITICAL ANALYSIS OF NEN GUIDELINES G Pentheroudakis Associate Professsor of Oncology Medical School, University of Ioannina Chair, ESMO Guidelines DISCLOSURES NO CONFLICTS OF INTEREST TO DECLARE UPDATED
More informationAnota et al. Health and Quality of Life Outcomes 2014, 12:32
Anota et al. Health and Quality of Life Outcomes 2014, 12:32 RESEARCH Open Access Item response theory and factor analysis as a mean to characterize occurrence of response shift in a longitudinal quality
More informationif not: Did he/she smoke earlier? yes/no/ N/A if yes: amount (cigarettes/day):
*. Patient personal details Insurance number:.. Name:. Date of birth:... Gender: female / male Race: Asian-Indian / Caucasian / Black / N/A Date of diagnosis: Age at diagnosis:. Last day of treatment:
More informationSUPPLEMENTARY INFORMATION
Supplementary Table 1. Therapies for non-men1 pancreatic neuroendocrine tumours (NETs) (published after 2011) Somatostatin analogues Tumour type a Intervention Number of participants/information available
More information