2 nd line Therapy and Beyond NSCLC. Alan Sandler, M.D. Oregon Health & Science University

Size: px
Start display at page:

Download "2 nd line Therapy and Beyond NSCLC. Alan Sandler, M.D. Oregon Health & Science University"

Transcription

1 2 nd line Therapy and Beyond NSCLC Alan Sandler, M.D. Oregon Health & Science University

2 Treatment options for advanced or metastatic (stage IIIb/IV) NSCLC Suitable for chemotherapy Diagnosis Unsuitable/unwilling for chemotherapy Platinum-containing chemotherapy or single-agent chemotherapy for elderly or poor PS patients First line Best supportive care or clinical trial Disease progression Tarceva monotherapy Disease progression Chemotherapy (docetaxel or pemetrexed) Disease progression Second line Chemotherapy? Tarceva monotherapy Third line NSCLC = non-small-cell lung cancer; PS = performance status

3 Second-line Treatment for Advanced NSCLC Study Treatment Overall Response Rate Median Survival Time P-value Hanna et al. 1 Pemetrexed Docetaxel 9.1% 8.8% 8.3 months 7.9 months NS Shepherd et al. 2 Erlotinib Placebo 8.9% <1.0% 6.7 months 4.7 months <0.001 Shepherd et al. 3 Docetaxel BSC 7.0% 7.0 months 4.6 months < Hanna N, et al. J Clin Oncol. 2004;22: ; 2. Shepherd FA, et al. N Engl J Med. 2005;353: ; 3. Shepherd FA, et al. J Clin Oncol. 2000;18:

4 Prospective Trial of Second-line Treatment: Shepherd et al. N=204 Stage IIIB/IV NSCLC Failed/intolerant to 1 prior chemotherapy regimen PS 0-2 R A N D O M I Z E Docetaxel 100 mg/m 2 (n=49) Docetaxel 75 mg/m 2 (n=55) Best supportive care (n=100) Primary endpoint Overall survival Secondary endpoints Objective tumor response Duration of response Changes in quality of life Shepherd FA, et al. J Clin Oncol. 2000;18:

5 Chemotherapy versus BSC in Second-line Therapy of NSCLC Median overall survival 1-year survival Combined Docetaxel Arms BSC P- value 7.0 mos 4.6 mos % 19% Shepherd FA, et al. J Clin Oncol. 2000;18:

6 Hanna N, et al. J Clin Oncol. 2004;22: Phase III Pemetrexed versus Docetaxel for Second-line NSCLC N=571 Stage IIIB/IV NSCLC Failed/intolerant to 1 prior chemotherapy regimen PS 0-2 R A N D O M I Z E Pemetrexed 500 mg/m 2 + Vitamin B 12 + Folic acid + Dexamethasone (n=283) Docetaxel 75 mg/m 2 + Dexamethasone (n=288) Primary endpoint Overall survival Secondary endpoints Toxicity Objective response rate Progression-free survival Time to progression Quality of life

7 Pemetrexed vs Docetaxel: Survival Outcome Pemetrexed Group Docetaxel Group P-value MST 8.3 months 7.9 months NS 1-year survival 29.7% 29.7% NS Hanna N, et al. J Clin Oncol. 2004;22:

8 BR.21 Study Design Stratified by: Centre PS, 0/1 vs 2/3 Response, CR/PR vs Stable vs Prog n Prior regimens, 1 vs 2 Prior platinum, Yes vs no R A N D O M I S E Erlotinib* 150 mg daily Placebo 150 mg daily *2:1 Randomization Shepherd, et al. Proc ASCO 2004 (abstract 7022)

9 Percentage BR.21 Progression Free Survival Erlotinib, Placebo *HR 0.61, p=<0.001 PFS 2.2 mo. vs. 1.8 mo Months *Adjusted for stratification factors 8

10 Percentage BR.21 Overall Survival Erlotinib, Placebo *HR 0.72, p=0.001 MST 6.7 mo. vs. 4.7 mo. 31% % Months *Adjusted for stratification factors

11 Second line: Single Agent vs Combination Overall survival PFS Di Maio M et al. JCO 2009;27: by American Society of Clinical Oncology

12 Future Directions EML4-ALK cmet Inhibitors

13 Lung Cancer Mutation Consortium Molecular Abnormalities in lung adenocarcinoma Kris, Kris, et all ASCO 2011 n= 1000 Mutation found in 54% (280/516) of tumors completely tested (CI 50-59%)

14 Maximum change in tumor size (%) Tumor Responses to Crizotinib for Patients with ALK-positive NSCLC Progressive disease Stable disease Confirmed partial response Confirmed complete response % *Partial response patients with 100% change have non-target disease present *

15 c-met Pathway and c-met Signaling Inhibition Strategies Eder J P et al. Clin Cancer Res 2009;15: by American Association for Cancer Research

16 cmet Inhibitors Agent Company MOA Phase METMab Genentech Anti-c-MET Ab II AMG102 Amgen Anti-HGF Ab II (RCC, GBM, Prostate, others) Tivantinib ARQ 197 Arqule/Daiichi Selective c-met TKI III Cabozantinib (XL184) Exelixis/BMS Non-selective c-met, VEGFR2 and RET TKI II

17 5 Phase II: Erlotinib +/- MetMAb in Key eligibility: Stage IIIB/IV NSCLC 2 nd /3 rd -line NSCLC Tissue required PS 0 2 n=137* 2 nd/ 3 rd -line NSCLC R A N D O M I Z A T I O N Stratification factors: Tobacco history Performance status Histology Arm A Arm B MetMAb (15 mg/kg IV Q3W) + erlotinib (150 mg daily) Placebo (IV Q3W) + erlotinib (150 mg daily) n=69 n=68 Co-primary objectives: Other key objectives: PD PFS in Met Diagnostic positive patients (est. 50%) PFS in overall ITT population OS in Met Diagnostic Positive pts OS in overall ITT patients Overall response rate Safety/tolerability Add MetMAb Must be eligible to be treated with MetMAb n=27 Schiller, et al ASCO 2010

18 Probability of progression free Probability of survival MetMAb plus erlotinib in ITT population PFS: HR=1.09 Median (mo) HR (95% CI) Log-rank p-value No. of events Placebo + erlotinib MetMAb + erlotinib ( ) OS: HR=0.8 Median (mo) HR (95% CI) Log-rank p-value No. of events Placebo + erlotinib MetMAb + erlotinib ( ) Time to progression (months) Overall survival (months) 8

19 Probability of progression free Probability of survival MetMAb plus erlotinib in Met Dx+ patients PFS: HR=0.53 OS: HR= Median (mo) HR (95% CI) Log-rank p-value No. of events Placebo + erlotinib MetMAb + erlotinib ( ) Median (mo) HR (95% CI) Log-rank p-value No. of events Placebo + erlotinib MetMAb + erlotinib ( ) Time to progression (months) Overall survival (months) 9

20 ARQ 197 (Tivantinib): a Novel and Selective Tyrosine Kinase Inhibitor Non-ATP competitive inhibitor of c-met Novel mechanism of binding stabilizes inactive conformation of c-met 1 Compound demonstrates broad-spectrum, anti-tumor activity in a number of tumor xenograft models (including NSCLC) In vivo anti-tumor activity of ARQ EGFR inhibitor greater than either drug alone 2 Demonstration of safety and linear PK in phase I combination with EGFR inhibitor erlotinib 3,4 1. Munshi N et al. Mol Cancer Ther 2010;Epub ahead of print 2. Unpublished; courtesy of ArQule, Inc. and Kyowa Hakko Kirin Co., Ltd 3. Laux I et al. ASCO Goldman J et al. IASLC 2009

21 Proportion of Patients Progression-Free Results of the Phase 2 Trial Progression-Free Survival Patients N Erlotinib HR = (95% placebo CI, ); 83 P <.05 a 2.2 Erlotinib + tivantinib Erlotinib + placebo Median PFS, months Erlotinib + tivantinib Time From Randomization, months ITT population - Adjusted for sex, prior chemotherapy, best prior response, time from diagnosis, and EGFR mutation status.

22 Proportion of Patients Progression- Ffree Results of the Phase 2 Trial The PFS benefits in the subset of patients with non-squamous tumor histology was consistent with the ITT population (Figure 3) Patients N HR = 0.61 (95% CI, ); P <.05 a Median PFS, months E + T E + P Erlotinib + tivantinib Erlotinib + placebo T ime From Randomization, months Investigator assessment - Adjusted for sex, prior chemotherapy, best prior response, time from diagnosis, and EGFR mutation status.

23 Results of the Phase 2 Trial A PFS benefit associated with tivantinib plus erlotinib was observed in patients with tumors harboring amplified c-met, wild-type EGFR, or mutant KRAS n/n Median PFS (95% CI), months Tivantinib + Placebo + Erlotinib Erlotinib Squamous cell 26/ ( ) 2.0 ( ) Non-squamous cell 58/ ( ) 2.3 ( ) c-met FISH > 4 19/ ( ) 3.6 ( ) c-met FISH > 5 8/ (3.8 - NE) 3.6 ( ) EGFR mutant 6/ ( ) 4.9 ( ) EGFR wt 51/ ( ) 1.9 ( ) KRAS mutant 10/5 2.3 (1.8 - NE) 1.0 ( ) KRAS wt 49/ ( ) 2.3 ( ) 0.18 Unadjusted HR Favors ARQ 197/Erlotinib Favors Placebo/Erlotinib Cox proportional hazard ratio analysis of median progression-free survival by patient subgroup.

24 MARQUEE Phase III Study Design The MARQUEE study is a multicenter, phase 3, randomized, doubleblind, placebo-controlled clinical trial (Figure 5) 8 Phase 3 in NSCLC Inoperable, locally advanced or metastatic disease Non-squamous histology 1-2 regimens of prior chemo (no prior EGFR TKI) Prior platinum-based doublet therapy required R A N D O M I Z E Arm A: Arm B: Tivantinib (ARQ 197) Erlotinib mg PO QD 360 mg PO BID Placebo PO BID + Erlotinib 150 mg PO QD Endpoints 1 : OS (ITT population) 2 /Exploratory: PFS (ITT population) PK and PD analysis OS and PFS in EGFR wt patients Safety and toxicity QOL/FACT-L Biologic subgroup analysis Stratification by EGFR and KRAS mutational status

25

26 Outline EGFR inhibition Rationale EGFR-TKIs and Antibodies Chemotherapy-naïve patients Previously treated patients Angiogenesis Combining targeted agents

27 Second-line Treatment Options Increasing need for second-line treatment due to improved 1-year survival rates for first-line, platinum-based chemotherapy Relapsed NSCLC more likely to be resistant to agents used in first-line therapy Many new active drugs available (response rates are generally less than 10%) Pemetrexed (folate antimetabolite) Docetaxel (taxane) Erlotinib (tyrosine kinase inhibitor) Hanna N, et al. J Clin Oncol. 2004;22: ; Shepherd FA, et al. N Engl J Med. 2005;353:

28 Stinchcombe, et al The Oncologist 2008

29 Stinchcombe, et al The Oncologist 2008

30 EGFR-Inhibition Second/Third-line Therapy Phase III Trials

31 BR.21 Exploratory Analysis: Phase III Trial of Erlotinib for Advanced NSCLC Survival Across Subgroups Subset n All patients 731 PS PS Male 475 Female 256 <65 y y 279 Adenocarcinoma 365 Squamous cell carcinoma 222 Other histology 144 Prior weight loss <5% 486 Prior weight loss 5%-10% 132 Prior weight loss >10% 81 Never smoked 146 Current/ex-smoker prior regimen prior regimens 367 Tarceva (erlotinib) PI. Decreased risk of death Increased risk of death

32 BR.21 Exploratory Analysis: Phase III Trial of Erlotinib for Advanced NSCLC Survival Across Subgroups Subset n All patients 731 Prior platinum 678 No prior platinum 53 Prior taxane 267 No prior taxane 464 Best prior response: CR/PR 292 Best prior response: SD 287 Best prior response: PD 152 Dx to randomization: <6 mo 97 Dx to randomization: 6-12 mo 242 Dx to randomization: >12 mo 392 EGFR-positive* 127 EGFR-negative 111 EGFR-unknown 493 *EGFR status defined by immunohistochemistry. SD = stable disease. Tarceva (erlotinib) PI. Decreased risk of death Increased risk of death

EGFR inhibitors in NSCLC

EGFR inhibitors in NSCLC Suresh S. Ramalingam, MD Associate Professor Director of Medical Oncology Emory University i Winship Cancer Institute EGFR inhibitors in NSCLC Role in 2nd/3 rd line setting Role in first-line and maintenance

More information

Treatment of EGFR-Mutation+ NSCLC in 1st- and 2nd-Line

Treatment of EGFR-Mutation+ NSCLC in 1st- and 2nd-Line Treatment of EGFR-Mutation+ NSCLC in 1st- and 2nd-Line Martin Reck David F. Heigener Department of Thoracic Oncology Hospital Grosshansdorf Germany Identification of driver mutation in tumor specimens

More information

K-Ras signalling in NSCLC

K-Ras signalling in NSCLC Targeting the Ras-Raf-Mek-Erk pathway Egbert F. Smit MD PhD Dept. Pulmonary Diseases Vrije Universiteit VU Medical Centre Amsterdam, The Netherlands K-Ras signalling in NSCLC Sun et al. Nature Rev. Cancer

More information

July, ArQule, Inc.

July, ArQule, Inc. July, 2012 Safe Harbor This presentation and other statements by ArQule may contain forward-looking statements within the meaning of the Private Securities Litigation Reform Act with respect to clinical

More information

Slide 1. Slide 2 Maintenance Therapy Options. Slide 3. Maintenance Therapy in the Management of Non-Small Cell Lung Cancer. Maintenance Chemotherapy

Slide 1. Slide 2 Maintenance Therapy Options. Slide 3. Maintenance Therapy in the Management of Non-Small Cell Lung Cancer. Maintenance Chemotherapy Slide 1 Maintenance Therapy in the Management of Non-Small Cell Lung Cancer Frances A Shepherd, MD FRCPC Scott Taylor Chair in Lung Cancer Research Princess Margaret Hospital, Professor of Medicine, University

More information

Maintenance Therapy for Advanced NSCLC: When, What, Why & What s Left After Post-Maintenance Relapse?

Maintenance Therapy for Advanced NSCLC: When, What, Why & What s Left After Post-Maintenance Relapse? Maintenance Therapy for Advanced NSCLC: When, What, Why & What s Left After Post-Maintenance Relapse? Mark A. Socinski, MD Professor of Medicine Multidisciplinary Thoracic Oncology Program Lineberger Comprehensive

More information

Targeted Agents as Maintenance Therapy. Karen Kelly, MD Professor of Medicine UC Davis Cancer Center

Targeted Agents as Maintenance Therapy. Karen Kelly, MD Professor of Medicine UC Davis Cancer Center Targeted Agents as Maintenance Therapy Karen Kelly, MD Professor of Medicine UC Davis Cancer Center Disclosures Genentech Advisory Board Maintenance Therapy Defined Treatment Non-Progressing Patients Drug

More information

Choosing Optimal Therapy for Advanced Non-Squamous (NS) Non-Small Cell Lung Cancer

Choosing Optimal Therapy for Advanced Non-Squamous (NS) Non-Small Cell Lung Cancer Choosing Optimal Therapy for Advanced Non-Squamous (NS) Non-Small Cell Lung Cancer Jyoti D. Patel, MD Associate Professor Feinberg School of Medicine Robert H Lurie Comprehensive Cancer Center Northwestern

More information

Maintenance therapy in advanced non-small cell lung cancer. Egbert F. Smit MD PhD Dept Thoracic Oncology Netherlands Cancer Institute

Maintenance therapy in advanced non-small cell lung cancer. Egbert F. Smit MD PhD Dept Thoracic Oncology Netherlands Cancer Institute Maintenance therapy in advanced non-small cell lung cancer. Egbert F. Smit MD PhD Dept Thoracic Oncology Netherlands Cancer Institute e.smit@nki.nl Evolution of front line therapy in NSCLC unselected pts

More information

Maintenance Therapy for Advanced NSCLC: Which Patients, Which Approach?

Maintenance Therapy for Advanced NSCLC: Which Patients, Which Approach? Maintenance Therapy for Advanced NSCLC: Which Patients, Which Approach? Mark A. Socinski, MD Visiting Professor of Medicine and Thoracic Surgery Director, Lung Cancer Section, Division of Hematology/Oncology

More information

Maintenance paradigm in non-squamous NSCLC

Maintenance paradigm in non-squamous NSCLC Maintenance paradigm in non-squamous NSCLC L. Paz-Ares Hospital Universitario Virgen del Rocío Sevilla Agenda Theoretical basis The data The comparisons Agenda Theoretical basis The data The comparisons

More information

LONDON CANCER NEW DRUGS GROUP RAPID REVIEW. Erlotinib for the third or fourth-line treatment of NSCLC January 2012

LONDON CANCER NEW DRUGS GROUP RAPID REVIEW. Erlotinib for the third or fourth-line treatment of NSCLC January 2012 Disease background LONDON CANCER NEW DRUGS GROUP RAPID REVIEW Erlotinib for the third or fourth-line treatment of NSCLC January 2012 Lung cancer is the second most common cancer in the UK (after breast),

More information

Management Guidelines and Targeted Therapies in Metastatic Non-Small Cell Lung Cancer: An Oncologist s Perspective

Management Guidelines and Targeted Therapies in Metastatic Non-Small Cell Lung Cancer: An Oncologist s Perspective Management Guidelines and Targeted Therapies in Metastatic Non-Small Cell Lung Cancer: An Oncologist s Perspective Julie R. Brahmer, M.D. Associate Professor of Oncology The Sidney Kimmel Comprehensive

More information

Immune Checkpoint Inhibitors for Lung Cancer William N. William Jr.

Immune Checkpoint Inhibitors for Lung Cancer William N. William Jr. Immune Checkpoint Inhibitors for Lung Cancer William N. William Jr. Diretor de Onco-Hematologia Hospital BP, A Beneficência Portuguesa Non-Small Cell Lung Cancer PD-1/PD-L1 Inhibitors in second-line therapy

More information

Second-line treatment for advanced NSCLC

Second-line treatment for advanced NSCLC UNIVERSITY OF TORINO DEPARTMENT OF ONCOLOGY Second-line treatment for advanced NSCLC Silvia Novello silvia.novello@unito.it UNIVERSITY OF TORINO DEPARTMENT OF ONCOLOGY Life was so simple back in 2008 Di

More information

PROGNOSTIC AND PREDICTIVE BIOMARKERS IN NSCLC. Federico Cappuzzo Istituto Toscano Tumori Ospedale Civile-Livorno Italy

PROGNOSTIC AND PREDICTIVE BIOMARKERS IN NSCLC. Federico Cappuzzo Istituto Toscano Tumori Ospedale Civile-Livorno Italy PROGNOSTIC AND PREDICTIVE BIOMARKERS IN NSCLC Federico Cappuzzo Istituto Toscano Tumori Ospedale Civile-Livorno Italy Prognostic versus predictive Prognostic: In presence of the biomarker patient outcome

More information

1st line chemotherapy and contribution of targeted agents

1st line chemotherapy and contribution of targeted agents ESMO PRECEPTORSHIP PROGRAMME NON-SM ALL-CELL LUNG CANCER 1st line chemotherapy and contribution of targeted agents Yi-Long Wu Guangdong Lung Cancer Institute Guangdong General Hospital Guangdong Academy

More information

MAINTENANCE TREATMENT CHEMO MAINTENANCE OR TARGETED OF BOTH? Martin Reck Department of Thoracic Oncology LungenClinic Grosshansdorf

MAINTENANCE TREATMENT CHEMO MAINTENANCE OR TARGETED OF BOTH? Martin Reck Department of Thoracic Oncology LungenClinic Grosshansdorf MAINTENANCE TREATMENT CHEMO MAINTENANCE OR TARGETED OF BOTH? Martin Reck Department of Thoracic Oncology LungenClinic Grosshansdorf OUTLINE Background and Concept Switch Maintenance Continuation Maintenance

More information

Second-line treatment for advanced NSCLC

Second-line treatment for advanced NSCLC Second-line treatment for advanced NSCLC Silvia Novello silvia.novello@unito.it UNIVERSITY OF TORINO DEPARTMENT OF ONCOLOGY DISCLOSURE OF INTEREST Speaker Bureau: Eli Lilly, MSD, BI, BMS, Roche, AZ UNIVERSITY

More information

Metastatic NSCLC: Expanding Role of Immunotherapy. Evan W. Alley, MD, PhD Abramson Cancer Center at Penn Presbyterian

Metastatic NSCLC: Expanding Role of Immunotherapy. Evan W. Alley, MD, PhD Abramson Cancer Center at Penn Presbyterian Metastatic NSCLC: Expanding Role of Immunotherapy Evan W. Alley, MD, PhD Abramson Cancer Center at Penn Presbyterian Disclosures: No relevant disclosures Please note that some of the studies reported in

More information

Beyond ALK and EGFR: Novel molecularly driven targeted therapies in NSCLC Federico Cappuzzo AUSL della Romagna, Ravenna, Italy

Beyond ALK and EGFR: Novel molecularly driven targeted therapies in NSCLC Federico Cappuzzo AUSL della Romagna, Ravenna, Italy Beyond ALK and EGFR: Novel molecularly driven targeted therapies in NSCLC Federico Cappuzzo AUSL della Romagna, Ravenna, Italy Oncogenic drivers in NSCLC Certain tumours arise as a result of aberrant activation

More information

Antiangiogenic Agents in NSCLC Where are we? Which biomarkers? VEGF Is the Only Angiogenic Factor Present Throughout the Tumor Life Cycle

Antiangiogenic Agents in NSCLC Where are we? Which biomarkers? VEGF Is the Only Angiogenic Factor Present Throughout the Tumor Life Cycle Antiangiogenic Agents in NSCLC Where are we? Which biomarkers? Martin Reck Department e t of Thoracic c Oncology ogy Hospital Grosshansdorf Germany VEGF Is the Only Angiogenic Factor Present Throughout

More information

Immunotherapy in the clinic. Lung Cancer. Marga Majem 20 octubre 2017

Immunotherapy in the clinic. Lung Cancer. Marga Majem 20 octubre 2017 Immunotherapy in the clinic. Lung Cancer Marga Majem 20 octubre 2017 mmajem@santpau.cat Immunotherapy in the clinic. Lung Cancer Agenda Where we come from? Immunotherapy in Second line Immunotherapy in

More information

Plotting the course: optimizing treatment strategies in patients with advanced adenocarcinoma

Plotting the course: optimizing treatment strategies in patients with advanced adenocarcinoma Pieter E. Postmus University of Liverpool Liverpool, UK Plotting the course: optimizing treatment strategies in patients with advanced adenocarcinoma Disclosures Advisor Bristol-Myers Squibb AstraZeneca

More information

Sao Paulo, Abril 2014

Sao Paulo, Abril 2014 Tratamento de Manutencao e outros Sao Paulo, Abril 2014 Rogerio C. Lilenbaum, M.D. Professor of Medicine Yale Cancer Center Chief Medical Officer Smilow Cancer Hospital What Is Maintenance Therapy? Use

More information

Biomarkers of Response to EGFR-TKIs EORTC-NCI-ASCO Meeting on Molecular Markers in Cancer November 17, 2007

Biomarkers of Response to EGFR-TKIs EORTC-NCI-ASCO Meeting on Molecular Markers in Cancer November 17, 2007 Biomarkers of Response to EGFR-TKIs EORTC-NCI-ASCO Meeting on Molecular Markers in Cancer November 17, 2007 Bruce E. Johnson, MD Dana-Farber Cancer Institute, Brigham and Women s Hospital, and Harvard

More information

Strategies in the therapy of advanced NSCLC SAMO Winter-Conference 2008 on Chest tumors

Strategies in the therapy of advanced NSCLC SAMO Winter-Conference 2008 on Chest tumors Strategies in the therapy of advanced NSCLC SAMO Winter-Conference 2008 on Chest tumors Miklos Pless Medical Oncology Kantonsspital Winterthur 2 Setting the stage. 1995: Chemotherapy works! Meta-Analysis

More information

Incorporating Immunotherapy into the treatment of NSCLC

Incorporating Immunotherapy into the treatment of NSCLC Incorporating Immunotherapy into the treatment of NSCLC Suresh S. Ramalingam, MD Roberto C. Goizueta Chair for Cancer Research Assistant Dean for Cancer Research Deputy Director, Winship Cancer Institute

More information

Comparison of Gefitinib versus Docetaxel in Patients with Pre-Treated Non-Small Cell Lung Cancer (NSCLC)

Comparison of Gefitinib versus Docetaxel in Patients with Pre-Treated Non-Small Cell Lung Cancer (NSCLC) J Lung Cancer 2009;8(2):61-66 Comparison of Gefitinib versus Docetaxel in Patients with Pre-Treated Non-Small Cell Lung Cancer (NSCLC) More effective treatments in first, second, and third-line of metastatic

More information

Joachim Aerts Erasmus MC Rotterdam, Netherlands. Drawing the map: molecular characterization of NSCLC

Joachim Aerts Erasmus MC Rotterdam, Netherlands. Drawing the map: molecular characterization of NSCLC Joachim Aerts Erasmus MC Rotterdam, Netherlands Drawing the map: molecular characterization of NSCLC Disclosures Honoraria for advisory board/consultancy/speakers fee Eli Lilly Roche Boehringer Ingelheim

More information

NSCLC: Terapia medica nella fase avanzata. Paolo Bidoli S.C. Oncologia Medica H S. Gerardo Monza

NSCLC: Terapia medica nella fase avanzata. Paolo Bidoli S.C. Oncologia Medica H S. Gerardo Monza NSCLC: Terapia medica nella fase avanzata Paolo Bidoli S.C. Oncologia Medica H S. Gerardo Monza First-line Second-line Third-line Not approved CT AND SILENT APPROVAL Docetaxel 1999 Paclitaxel Gemcitabine

More information

EGFR MUTATIONS: EGFR PATHWAY AND SELECTION OF FIRST-LINE THERAPY WITH TYROSINE KINASE INHIBITORS

EGFR MUTATIONS: EGFR PATHWAY AND SELECTION OF FIRST-LINE THERAPY WITH TYROSINE KINASE INHIBITORS EGFR MUTATIONS: EGFR PATHWAY AND SELECTION OF FIRST-LINE THERAPY WITH TYROSINE KINASE INHIBITORS Federico Cappuzzo Istituto Clinico Humanitas IRCCS Rozzano-Italy The EGFR/HER Family Ligand binding domain

More information

Non-small Cell Lung Cancer: Multidisciplinary Role: Role of Medical Oncologist

Non-small Cell Lung Cancer: Multidisciplinary Role: Role of Medical Oncologist Non-small Cell Lung Cancer: Multidisciplinary Role: Role of Medical Oncologist Vichien Srimuninnimit, MD. Medical Oncology Division Faculty of Medicine, Siriraj Hospital Outline Resectable NSCLC stage

More information

Virtual Journal Club: Front-Line Therapy and Beyond Recent Perspectives on ALK-Positive Non-Small Cell Lung Cancer.

Virtual Journal Club: Front-Line Therapy and Beyond Recent Perspectives on ALK-Positive Non-Small Cell Lung Cancer. Virtual Journal Club: Front-Line Therapy and Beyond Recent Perspectives on ALK-Positive Non-Small Cell Lung Cancer Reference Slides ALK Rearrangement in NSCLC ALK (anaplastic lymphoma kinase) is a receptor

More information

Do You Think Like the Experts? Refining the Management of Advanced NSCLC With ALK Rearrangement. Reference Slides Introduction

Do You Think Like the Experts? Refining the Management of Advanced NSCLC With ALK Rearrangement. Reference Slides Introduction Do You Think Like the Experts? Refining the Management of Advanced NSCLC With ALK Rearrangement Reference Slides Introduction EML4-ALK Fusion Oncogene Key Driver in 3% to 7% NSCLC Inversion or Translocation

More information

Nivolumab: esperienze italiane nel carcinoma polmonare avanzato

Nivolumab: esperienze italiane nel carcinoma polmonare avanzato NSCLC avanzato: quali novità nel 2018? Negrar, 30 Ottobre 2018 Nivolumab: esperienze italiane nel carcinoma polmonare avanzato Francesco Grossi UOC Oncologia Medica Fondazione IRCCS Ca Granda Ospedale

More information

Practice changing studies in lung cancer 2017

Practice changing studies in lung cancer 2017 1 Practice changing studies in lung cancer 2017 Rolf Stahel University Hospital of Zürich Cape Town, February 16, 2018 DISCLOSURE OF INTEREST Consultant or Advisory Role in the last two years I have received

More information

Slide 1. Slide 2. Slide 3. Individualized Therapy in Lung Cancer : Where are we in 2011? Notable Advances in Cancer Research in the last 2 years

Slide 1. Slide 2. Slide 3. Individualized Therapy in Lung Cancer : Where are we in 2011? Notable Advances in Cancer Research in the last 2 years Slide 1 Individualized Therapy in Lung Cancer : Where are we in 2011? Giorgio V. Scagliotti University of Torino Department of Clinical & Biological Sciences giorgio.scagliotti@unito.it Slide 2 Notable

More information

New Options for Achieving Individualized Approaches to Non-Small Cell Lung Cancer (NSCLC) Management

New Options for Achieving Individualized Approaches to Non-Small Cell Lung Cancer (NSCLC) Management New Options for Achieving Individualized Approaches to Non-Small Cell Lung Cancer (NSCLC) Management Ramaswamy Govindan, MD Director Professor of Medicine Director, Thoracic Oncology Program Department

More information

Update on the Management of HER2+ Breast Cancer. Christian Jackisch, MD, PhD Sana Klinikum Offenbach Offenbach, Germany

Update on the Management of HER2+ Breast Cancer. Christian Jackisch, MD, PhD Sana Klinikum Offenbach Offenbach, Germany Update on the Management of HER2+ Breast Cancer Christian Jackisch, MD, PhD Sana Klinikum Offenbach Offenbach, Germany Outline Treatment strategies for HER2-positive metastatic breast cancer since First

More information

Lung Cancer Case. Since the patient was symptomatic, a targeted panel was sent. ALK FISH returned in 2 days and was positive.

Lung Cancer Case. Since the patient was symptomatic, a targeted panel was sent. ALK FISH returned in 2 days and was positive. Lung Cancer Case Jonathan Riess, M.D. M.S. Assistant Professor of Medicine University of California Davis School of Medicine UC Davis Comprehensive Cancer Center 63 year-old woman, never smoker, presents

More information

in combination with cisplatin as first-line doublet 3 as maintenance agent following non-pemetrexed platinum doublet 4

in combination with cisplatin as first-line doublet 3 as maintenance agent following non-pemetrexed platinum doublet 4 Overall survival (OS) results from PARAMOUNT study of maintenance plus best supportive care (BSC) versus plus BSC, immediately after induction with - Cisplatin, in patients with advanced Nonsquamous Non-small

More information

LUNG CANCER TREATMENT: AN OVERVIEW

LUNG CANCER TREATMENT: AN OVERVIEW LUNG CANCER TREATMENT: AN OVERVIEW KONSTANTINOS N. SYRIGOS, M.D., Ph.D. Αναπλ. Καθηγητής Παθολογίας-Ογκολογίας, Ιατρικής Σχολής Αθηνών. Διευθυντής Ογκολογικής Μονάδας, Νοσ. «Η Σωτηρία». Visiting Professor

More information

CheckMate 012: Safety and Efficacy of First Line Nivolumab and Ipilimumab in Advanced Non-Small Cell Lung Cancer

CheckMate 012: Safety and Efficacy of First Line Nivolumab and Ipilimumab in Advanced Non-Small Cell Lung Cancer CheckMate 12: Safety and Efficacy of First Line Nivolumab and Ipilimumab in Advanced Non-Small Cell Lung Cancer Abstract 31 Hellmann MD, Gettinger SN, Goldman J, Brahmer J, Borghaei H, Chow LQ, Ready NE,

More information

Lung Cancer Non-small Cell Local, Regional, Small Cell, Other Thoracic Cancers: The Question Isn t Can We, but Should We

Lung Cancer Non-small Cell Local, Regional, Small Cell, Other Thoracic Cancers: The Question Isn t Can We, but Should We Lung Cancer Non-small Cell Local, Regional, Small Cell, Other Thoracic Cancers: The Question Isn t Can We, but Should We Edward Garon, MD, MS Associate Professor Director- Thoracic Oncology Program David

More information

PRACTICE GUIDELINE SERIES

PRACTICE GUIDELINE SERIES ELLIS et al. PRACTICE GUIDELINE SERIES The role of the epidermal growth factor receptor tyrosine kinase inhibitors as therapy for advanced, metastatic, and recurrent nonsmall-cell lung cancer: a Canadian

More information

11/21/2009. Erlotinib in KRAS Mt patients. Bevacizumab in Squamous patients

11/21/2009. Erlotinib in KRAS Mt patients. Bevacizumab in Squamous patients Decision-Making in Non-Small Cell Lung Cancer (NSCLC): Moving from Empiric to Personalized & Molecular-based Therapy David R. Gandara, MD University of California Davis Cancer Center Disclosures Research

More information

Antiangiogenici in combinazione a chemioterapia in prima linea: bevacizumab

Antiangiogenici in combinazione a chemioterapia in prima linea: bevacizumab Micro-ambiente tumorale. Antiangiogenici e immunoterapia: miti e realtà Milano, 11 Ottobre 2016 Antiangiogenici in combinazione a chemioterapia in prima linea: bevacizumab Francesco Grossi U.O.S. Tumori

More information

Patient Selection: The Search for Immunotherapy Biomarkers

Patient Selection: The Search for Immunotherapy Biomarkers Patient Selection: The Search for Immunotherapy Biomarkers Mark A. Socinski, MD Executive Medical Director Florida Hospital Cancer Institute Orlando, Florida Patient Selection Clinical smoking status Histologic

More information

Treatment of EGFR mutant advanced NSCLC

Treatment of EGFR mutant advanced NSCLC Treatment of EGFR mutant advanced NSCLC Raffaele Califano Department of Medical Oncology The Christie and Manchester University Hospital Manchester, UK Outline Data on first-line Overcoming T790M mutation

More information

1st-line Chemotherapy for Advanced disease

1st-line Chemotherapy for Advanced disease SESSION 3: ADVANCED NSCLC 1st-line Chemotherapy for Advanced disease JY DOUILLARD MD PhD Professor Emeritus in Medical Oncology Chief Medical Officer (CMO) ESMO Lugano CH Percent Survival HISTORICAL BASIS

More information

Exploring Personalized Therapy for First Line Treatment of Advanced Non-Small Cell Lung Cancer (NSCLC)

Exploring Personalized Therapy for First Line Treatment of Advanced Non-Small Cell Lung Cancer (NSCLC) Exploring Personalized Therapy for First Line Treatment of Advanced Non-Small Cell Lung Cancer (NSCLC) Suresh S. Ramalingam, MD Director of Thoracic Oncology Associate Professor Emory University Atlanta,

More information

Changing demographics of smoking and its effects during therapy

Changing demographics of smoking and its effects during therapy Changing demographics of smoking and its effects during therapy Egbert F. Smit MD PhD. Dept. Pulmonary Diseases, Vrije Universiteit Medical Centre, Amsterdam, The Netherlands Smoking prevalence adults

More information

LUNG CANCER. Başak Oyan-Uluç, MD Yeditepe University Hospital Medical Oncology. Best of ASCO, İstanbul

LUNG CANCER. Başak Oyan-Uluç, MD Yeditepe University Hospital Medical Oncology. Best of ASCO, İstanbul LUNG CANCER Başak Oyan-Uluç, MD Yeditepe University Hospital Medical Oncology Best of ASCO, İstanbul 2012 23.6.2012 Treatment of Metastatic NSCLC EGFR targetted treatments 1st line: EGFR-mutated: Afatinib

More information

Heather Wakelee, M.D.

Heather Wakelee, M.D. Heather Wakelee, M.D. Assistant Professor of Medicine, Oncology Stanford University Sponsored by Educational Grant Support from Adjuvant (Post-Operative) Lung Cancer Chemotherapy Heather Wakelee, M.D.

More information

Maintenance Treatment for Advanced NSCLC. Yvonne Summers PhD, FRCP ESMO Preceptorship Programme March 2017

Maintenance Treatment for Advanced NSCLC. Yvonne Summers PhD, FRCP ESMO Preceptorship Programme March 2017 Maintenance Treatment for Advanced NSCLC Yvonne Summers PhD, FRCP ESMO Preceptorship Programme March 2017 Milestones in the Palliative Systemic Treatment of NSCLC 1990 2000 2010 2015 Platinum based Chemotherapy

More information

1 st line chemotherapy and contribution of targeted agents in non-driver addicted NSCLC

1 st line chemotherapy and contribution of targeted agents in non-driver addicted NSCLC 1 st line chemotherapy and contribution of targeted agents in non-driver addicted NSCLC Dr Ross Soo, FRACP National University Cancer Institute, Singapore National University Health System Cancer Science

More information

ESMO THE CHRISTIE PRECEPTORSHIP PROGRAMME. 1 st line chemotherapy for advanced NSCLC. Benjamin BESSE, MD, PhD Head Dpt of Cancer Medicine

ESMO THE CHRISTIE PRECEPTORSHIP PROGRAMME. 1 st line chemotherapy for advanced NSCLC. Benjamin BESSE, MD, PhD Head Dpt of Cancer Medicine ESMO THE CHRISTIE PRECEPTORSHIP PROGRAMME 1 st line chemotherapy for advanced NSCLC Benjamin BESSE, MD, PhD Head Dpt of Cancer Medicine 2017 PD-L1 50% Pembrolizuma b [I,A] Courtesy of J.Remon Adapted from

More information

Combined Modality Therapy State of the Art. Everett E. Vokes The University of Chicago

Combined Modality Therapy State of the Art. Everett E. Vokes The University of Chicago Combined Modality Therapy State of the Art Everett E. Vokes The University of Chicago What we Know Some patients are cured (20%) Induction and concurrent chemoradiotherapy are each superior to radiotherapy

More information

Recent Therapeutic Advances for Thoracic Malignancies

Recent Therapeutic Advances for Thoracic Malignancies Recent Therapeutic Advances for Thoracic Malignancies Developed in collaboration Learning Objectives Upon completion, participants should be able to: Interpret new developments in the use of radiation

More information

Personalized Medicine for Advanced NSCLC in East Asia

Personalized Medicine for Advanced NSCLC in East Asia Personalized Medicine for Advanced NSCLC in East Asia - Update treatment strategy for NSCLC based on Japanese clinical practice guideline - Masahiro Tsuboi, M.D., Ph.D. Associate-professor, School of Medicine,

More information

Proteomic Testing for Targeted Therapy in Non-Small-Cell Lung Cancer

Proteomic Testing for Targeted Therapy in Non-Small-Cell Lung Cancer Last Review Status/Date: December 2015 Page: 1 of 21 Small-Cell Lung Cancer Summary Proteomic testing has been proposed as a way to predict outcomes and response to and selection of targeted therapy for

More information

Re-Submission. Scottish Medicines Consortium. erlotinib, 100 and 150mg film-coated tablets (Tarceva ) No. 220/05 Roche. 5 May 2006

Re-Submission. Scottish Medicines Consortium. erlotinib, 100 and 150mg film-coated tablets (Tarceva ) No. 220/05 Roche. 5 May 2006 Scottish Medicines Consortium Re-Submission erlotinib, 100 and 150mg film-coated tablets (Tarceva ) No. 220/05 Roche 5 May 2006 The Scottish Medicines Consortium (SMC) has completed its assessment of the

More information

PERIOPERATIVE TREATMENT OF NON SMALL CELL LUNG CANCER. Virginie Westeel Chest Disease Department University Hospital Besançon, France

PERIOPERATIVE TREATMENT OF NON SMALL CELL LUNG CANCER. Virginie Westeel Chest Disease Department University Hospital Besançon, France PERIOPERATIVE TREATMENT OF NON SMALL CELL LUNG CANCER Virginie Westeel Chest Disease Department University Hospital Besançon, France LEARNING OBJECTIVES 1. To understand the potential of perioperative

More information

Squamous Cell Carcinoma Standard and Novel Targets.

Squamous Cell Carcinoma Standard and Novel Targets. Squamous Cell Carcinoma Standard and Novel Targets. Mohamed K. Mohamed, MD, PhD Director of Thoracic Oncology Cone Health Cancer Center Greensboro, NC 1 Mohamed Mohamed, MD, PhD Squamous Cell Carcinoma:

More information

OUR EXPERIENCES WITH ERLOTINIB IN SECOND AND THIRD LINE TREATMENT PATIENTS WITH ADVANCED STAGE IIIB/ IV NON-SMALL CELL LUNG CANCER

OUR EXPERIENCES WITH ERLOTINIB IN SECOND AND THIRD LINE TREATMENT PATIENTS WITH ADVANCED STAGE IIIB/ IV NON-SMALL CELL LUNG CANCER & OUR EXPERIENCES WITH ERLOTINIB IN SECOND AND THIRD LINE TREATMENT PATIENTS WITH ADVANCED STAGE IIIB/ IV NON-SMALL CELL LUNG CANCER Interim Data Report of TRUST study on patients from Bosnia and Herzegovina

More information

SURGICAL GRAND ROUNDS

SURGICAL GRAND ROUNDS SURGICAL GRAND ROUNDS David H. Harpole, Jr., M.D. New Options for Achieving Individualized Approaches to Non-small Cell Lung Cancer Management Dr. Harpole has financial relationships with the following

More information

Molecular Targets in Lung Cancer

Molecular Targets in Lung Cancer Molecular Targets in Lung Cancer Robert Ramirez, DO, FACP Thoracic and Neuroendocrine Oncology November 18 th, 2016 Disclosures Consulting and speaker fees for Ipsen Pharmaceuticals, AstraZeneca and Merck

More information

Thoracic and head/neck oncology new developments

Thoracic and head/neck oncology new developments Thoracic and head/neck oncology new developments Goh Boon Cher Department of Hematology-Oncology National University Cancer Institute of Singapore Research Clinical Care Education Scope Lung cancer Screening

More information

Target therapy nel NSCLC con EGFR M+ Cesare Gridelli Division of Medical Oncology S.G. Moscati Hospital Avellino (Italy)

Target therapy nel NSCLC con EGFR M+ Cesare Gridelli Division of Medical Oncology S.G. Moscati Hospital Avellino (Italy) Target therapy nel NSCLC con EGFR M+ Cesare Gridelli Division of Medical Oncology S.G. Moscati Hospital Avellino (Italy) cgridelli@libero.it First-Line Treatment of Advanced NSCLC EGFR-mutation analysis

More information

Monoclonal Antibodies in the Management of Non-Small Cell Lung Cancer (NSCLC): 2016 Update Angioinhibitors and EGFR MAbs

Monoclonal Antibodies in the Management of Non-Small Cell Lung Cancer (NSCLC): 2016 Update Angioinhibitors and EGFR MAbs Monoclonal Antibodies in the Management of Non-Small Cell Lung Cancer (NSCLC): 2016 Update Angioinhibitors and EGFR MAbs Corey J Langer, MD, FACP Director Thoracic Oncology Abramson Cancer Center Professor

More information

Malignant pleural Mesothelioma: A Year In Review

Malignant pleural Mesothelioma: A Year In Review Malignant pleural Mesothelioma: A Year In Review Rabab Gaafar,MD Prof. Medical Oncology NCI Cairo University National Cancer Institute Conference 2015 ASCO news in Mesothelioma Introduction ASCO news second

More information

Targeted therapies for advanced non-small cell lung cancer. Tom Stinchcombe Duke Cancer Insitute

Targeted therapies for advanced non-small cell lung cancer. Tom Stinchcombe Duke Cancer Insitute Targeted therapies for advanced non-small cell lung cancer Tom Stinchcombe Duke Cancer Insitute Topics ALK rearranged NSCLC ROS1 rearranged NSCLC EGFR mutation: exon 19/exon 21 L858R and uncommon mutations

More information

Rob Ross, MD. Infinity Pharmaceuticals March 9 th, 2011

Rob Ross, MD. Infinity Pharmaceuticals March 9 th, 2011 Heat Shock Protein 90 (Hsp90) Inhibition as a Potential Novel Approach to the Treatment of Patients with ALK Mutated Non-small Cell Lung Cancer (NSCLC) Rob Ross, MD Infinity Pharmaceuticals March 9 th,

More information

Combined treatment with MET inhibitors and other therapies in lung cancer

Combined treatment with MET inhibitors and other therapies in lung cancer Perspective Combined treatment with MET inhibitors and other therapies in lung cancer Rakesh Bagai 1,2, Patrick C. Ma 1,2,3 1 Translational Hematology and Oncology Research, and 2 Solid Tumor Oncology,

More information

The Evolving Role of Molecular Markers in Managing Non-Small Cell Lung Cancer

The Evolving Role of Molecular Markers in Managing Non-Small Cell Lung Cancer The Evolving Role of Molecular Markers in Managing Non-Small Cell Lung Cancer Nathan A. Pennell, M.D., Ph.D. Assistant Professor Solid Tumor Oncology Cleveland Clinic Taussig Cancer Institute www.cancergrace.org

More information

Overall survival with afatinib versus chemotherapy in patients with NSCLC harboring common EGFR

Overall survival with afatinib versus chemotherapy in patients with NSCLC harboring common EGFR Overall survival with afatinib versus chemotherapy in patients with NSCLC harboring common EGFR mutations: subgroup analyses by race/ethnicity in LUX-Lung 3 and LUX-Lung 6 Yi-Long Wu, 1 Lecia V Sequist,

More information

Immune checkpoint blockade in lung cancer

Immune checkpoint blockade in lung cancer Immune checkpoint blockade in lung cancer Raffaele Califano Department of Medical Oncology The Christie and University Hospital of South Manchester, Manchester, UK Outline Background Overview of the data

More information

VEGF-Inhibitors in NSCLC. Martin Reck Department of Thoracic Oncology Hospital Grosshansdorf Germany

VEGF-Inhibitors in NSCLC. Martin Reck Department of Thoracic Oncology Hospital Grosshansdorf Germany VEGF-Inhibitors in NSCLC Martin Reck Department of Thoracic Oncology Hospital Grosshansdorf Germany Conflicts of interest Advisory Board: AstraZeneca Bristol-Myers Squibb Daiichi Sankyo Eli Lilly Merck

More information

Tratamiento Multidisciplinar de Estadios Localmente Avanzados en Cáncer de Pulmón

Tratamiento Multidisciplinar de Estadios Localmente Avanzados en Cáncer de Pulmón Tratamiento Multidisciplinar de Estadios Localmente Avanzados en Cáncer de Pulmón Santiago Ponce Aix Servicio Oncología Médica Hospital Universitario 12 de Octubre Madrid Stage III: heterogenous disease

More information

Treatment of EGFR mutant advanced NSCLC

Treatment of EGFR mutant advanced NSCLC Treatment of EGFR mutant advanced NSCLC Raffaele Califano Department of Medical Oncology The Christie and University Hospital of South Manchester, Manchester, UK Outline Data on first-line Overcoming T790M

More information

Development of Rational Drug Combinations for Oncology Indications - An Industry Perspective

Development of Rational Drug Combinations for Oncology Indications - An Industry Perspective Development of Rational Drug Combinations for Oncology Indications An Industry Perspective Stuart Lutzker, MDPhD Vice President Oncology Early Development Genentech Inc 1 Conventional Oncology Drug Development

More information

ALK Inhibition: From Biology to Approved Therapy for Advanced Non-Small Cell Lung Cancer

ALK Inhibition: From Biology to Approved Therapy for Advanced Non-Small Cell Lung Cancer ALK Inhibition: From Biology to Approved Therapy for Advanced Non-Small Cell Lung Cancer Dr. Ben Solomon Medical Oncologist, Thoracic Oncology Peter MacCallum Cancer Centre Melbourne, Australia Dr. D.

More information

Improving outcomes for NSCLC patients with brain metastases

Improving outcomes for NSCLC patients with brain metastases Improving outcomes for NSCLC patients with brain metastases Martin Schuler West German Cancer Center, Essen, Germany In Switzerland, afatinib is approved as monotherapy for patients with non-small cell

More information

Debate 1 Are treatments for small cell lung cancer getting better? No:

Debate 1 Are treatments for small cell lung cancer getting better? No: Debate 1 Are treatments for small cell lung cancer getting better? No: Taofeek Owonikoko, MD, PhD Associate Professor Department of Hematology & Medical Oncology Winship Cancer Institute of Emory University

More information

Test Category: Prognostic and Predictive. Clinical Scenario

Test Category: Prognostic and Predictive. Clinical Scenario Use of Epidermal Growth Factor Receptor (EGFR) Mutation Analysis in Patients with Advanced Non-Small-Cell Lung Cancer (NSCLC) to Determine Erlotinib Use as First-line Therapy Test Category: Prognostic

More information

Targeted/Immunotherapy & Molecular Profiling State-of-the-art in Cancer Care

Targeted/Immunotherapy & Molecular Profiling State-of-the-art in Cancer Care Targeted/Immunotherapy & Molecular Profiling State-of-the-art in Cancer Care Manmeet Ahluwalia, MD, FACP Miller Family Endowed Chair in Neuro-Oncology Director Brain Metastasis Research Program Cleveland

More information

II sessione. Immunoterapia oltre la prima linea. Alessandro Tuzi ASST Sette Laghi, Varese

II sessione. Immunoterapia oltre la prima linea. Alessandro Tuzi ASST Sette Laghi, Varese II sessione Immunoterapia oltre la prima linea Alessandro Tuzi ASST Sette Laghi, Varese AGENDA Immunotherapy post-chemo ( true 2/3L ) Immunotherapy in oncogene addicted NSCLC (yes/no? when?) Immunotherapy

More information

Panitumumab: The KRAS Story. Chrissie Fletcher, MSc. BSc. CStat. CSci. Director Biostatistics, Amgen Ltd

Panitumumab: The KRAS Story. Chrissie Fletcher, MSc. BSc. CStat. CSci. Director Biostatistics, Amgen Ltd Panitumumab: The KRAS Story Chrissie Fletcher, MSc. BSc. CStat. CSci. Director Biostatistics, Amgen Ltd Clinical Background: panitumumab in mcrc Panitumumab is a fully human IgG2 monoclonal antibody directed

More information

ALCHEMIST. Adjuvant Lung Cancer Enrichment Marker Identification And Sequencing Trials

ALCHEMIST. Adjuvant Lung Cancer Enrichment Marker Identification And Sequencing Trials ALCHEMIST Adjuvant Lung Cancer Enrichment Marker Identification And Sequencing Trials What is ALCHEMIST? ALCHEMIST is 3 integrated trials testing targeted therapy in early stage lung cancer: l A151216:

More information

Targeted Therapies for Advanced NSCLC

Targeted Therapies for Advanced NSCLC Targeted Therapies for Advanced NSCLC Current Clinical Developments Friday, June 3, 2016 Supported by an independent educational grant from AstraZeneca Not an official event of the 2016 ASCO Annual Meeting

More information

Chemotherapy and Immunotherapy in Combination Non-Small Cell Lung Cancer (NSCLC)

Chemotherapy and Immunotherapy in Combination Non-Small Cell Lung Cancer (NSCLC) Chemotherapy and Immunotherapy in Combination Non-Small Cell Lung Cancer (NSCLC) Jeffrey Crawford, MD George Barth Geller Professor for Research in Cancer Co-Program Leader, Solid Tumor Therapeutics Program

More information

EGFR Tyrosine Kinase Inhibitors Prolong Overall Survival in EGFR Mutated Non-Small-Cell Lung Cancer Patients with Postsurgical Recurrence

EGFR Tyrosine Kinase Inhibitors Prolong Overall Survival in EGFR Mutated Non-Small-Cell Lung Cancer Patients with Postsurgical Recurrence 102 Journal of Cancer Research Updates, 2012, 1, 102-107 EGFR Tyrosine Kinase Inhibitors Prolong Overall Survival in EGFR Mutated Non-Small-Cell Lung Cancer Patients with Postsurgical Recurrence Kenichi

More information

Evolving Paradigms in HER2+ MBC: Strategies for Individualizing Therapy with Available Agents

Evolving Paradigms in HER2+ MBC: Strategies for Individualizing Therapy with Available Agents Evolving Paradigms in HER2+ MBC: Strategies for Individualizing Therapy with Available Agents Kimberly L. Blackwell MD Professor Department of Medicine and Radiation Oncology Duke University Medical Center

More information

Targeted therapy in lung cancer : experience of NIO-RABAT

Targeted therapy in lung cancer : experience of NIO-RABAT Targeted therapy in lung cancer : experience of NIO-RABAT I.ELGHISSASSI, H.ERRIHANI Medical oncology department, NIO- RABAT 02-05- 2012, FEZ In Morocco, lung cancer is the most common tumor among men At

More information

Successes and Challenges in Treating Squamous Cell Carcinoma of the Lung

Successes and Challenges in Treating Squamous Cell Carcinoma of the Lung Successes and Challenges in Treating Squamous Cell Carcinoma of the Lung Noemi Reguart,MD, PhD Hospital Clinic de Barcelona Barcelona, Spain SC-CRP-02660 Conversations in Oncology 2018 is a standalone

More information

Recent advances in the management of metastatic breast cancer in older adults

Recent advances in the management of metastatic breast cancer in older adults Recent advances in the management of metastatic breast cancer in older adults Laura Biganzoli Medical Oncology Dept New Hospital of Prato Istituto Toscano Tumori Italy Important recent advances in the

More information

Quale sequenza terapeutica nella malattia EGFR+

Quale sequenza terapeutica nella malattia EGFR+ Trattamento della malattia avanzata oncogene-addicted Quale sequenza terapeutica nella malattia EGFR+ Chiara Bennati AUSL della Romagna Ravenna, Italy A matter of fact Outline Can we improve PFS/OS with

More information

Heat shock proteins as an emerging therapeutic target

Heat shock proteins as an emerging therapeutic target UNIVERSITY OF OF TORINO DEPARTMENT OF ONCOLOGY Heat shock proteins as an emerging therapeutic target Giorgio V. Scagliotti University of Torino Professor of Medical Oncology Department of Oncology giorgio.scagliotti@unito.it

More information

Long term survival in EGFR positive NSCLC patient. Dr.ssa G. Zago Oncologia Medica 2 Istituto Oncologico Veneto, IOV

Long term survival in EGFR positive NSCLC patient. Dr.ssa G. Zago Oncologia Medica 2 Istituto Oncologico Veneto, IOV Long term survival in EGFR positive NSCLC patient Dr.ssa G. Zago Oncologia Medica 2 Istituto Oncologico Veneto, IOV Medical history and diagnosis Male, caucasian 60 years old Former smoker (stop > 15 years)

More information