CURRICULUM VITAE. San Diego Cancer Center/ Medical Group of North County, Inc. Encinitas, CA (760) (760) (760) fax

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1 CURRICULUM VITAE Laurie A. Frakes, M.D. 477 N. El Camino Road Suite D200 Encinitas, CA California Cancer Associates for Research & Excellence, Inc. EDUCATION Fellowship Hematology/Oncology, Scripps Clinic and Research Foundation, La Jolla, California, USA, FRCPC/ABIM Residency in Internal Medicine, Calgary, Alberta, Canada,1994. M.D. University of Calgary, Alberta, Canada, MSc. University of Calgary, Alberta, Canada, BSc. University of Waterloo, Ontario, Canada, PROFESSIONAL EXPERIENCE 07/05 to present California Cancer Associates for Research & Excellence, Inc. (Formerly San Diego Pacific Oncology) Private practice. Hospital privileges as below. Address: 477 N. El Camino Real Suite D200, Encinitas, CA Thunder Drive, Suite 106, Vista, CA Dove Canyon Road, Ste 103, San Diego, CA /97-07/05 San Diego Cancer Center. Hospital privileges at TriCity Hospital, Vista, Ca., Scripps Memorial Hospital, Encinitas and La Jolla, Ca. Active involvement in clinical trials through University of California, Los Angeles (UCLA) network, University of California, San Diego (UCSD) and Scripps Stevens Cancer Center. San Diego Cancer Center/ Medical Group of North County, Inc. 910 Sycamore Avenue, Suite Gardenview Rd #200 Vista, CA Encinitas, CA (760) (760) (760) fax (760) fax 07/94-06/97 Fellow, Department of Hematology and Oncology, Green Cancer Center, Scripps Clinic and Research Foundation, La Jolla, Ca. Third year specialty in bone marrow transplantation. 06/91-06/94 Resident, Internal Medicine, Foothills Hospital, Calgary, Alberta, Canada.

2 RESEARCH EXPERIENCE Present Clinical Trials Scripps Cancer Center, Phase 1 Program Scripps Cancer Center, N Torrey Pines Rd, Ste 200, La Jolla, CA Involved in clinical trials research through UCLA, UCSD and Scripps Cancer Center Principal investigator, Pilot Study of an Antiemetic Regimen for use in High-Dose Chemotherapy with Autologous Stem Cell Rescue, Scripps Clinic and Research Foundation, La Jolla, California Co-investigator, Outcome study of Quality Assurance of Heparin Delivery in a Hospital Setting, Department of Internal Medicine, Calgary, Alberta, Canada Research Elective Thesis, Interventive Interviewing as a Means of Therapy in Patients with Eating Disorders. Department of Psychiatry, Calgary, Alberta, Canada Master's Thesis, Investigation of the Role of Plasminogen Activator Inhibitors in Cell Differentiation, Department of Immunology University of Calgary, Alberta, Canada Graduating Honours Thesis, Interleukin-1 Activity in Cultured Rat Thymus Cells, Department of Health Studies, University of Waterloo, Ontario, Canada. TEACHING EXPERIENCE 1996 Lecturer for Making Sense -a community educational program for breast cancer patients and their families Scripps Clinic- Attending Rounds with Internal Medicine Residents present University of California, San Diego-Clinical Preceptor University of Calgary- Supervision of interns and residents including didactic and bedside teaching. AWARDS Alberta Heritage Foundation for Medical Research Studentship, Multiple Sclerosis Society of Canada Scholarship, University of Calgary Fee Scholarship, 1986.

3 University of Waterloo Work Report Award, National Science and Engineering Research Council of Canada (NSERC) Studentship, Ontario Scholarship Award, Entrance Scholarship, University of Waterloo, Ontario, Canada, LICENSES AND CERTIFICATIONS 1993-present Medical Licensure, State of California, #A present Federal DEA Registration Certificate #BF September, 1998 Diplomate of the American Board of Internal Medicine in Hematology. November, 1997 Fellow of the Royal College of Physicians and Surgeons of Canada, Speciality Certification in Medical Oncology. September, Diplomate of the American Board of Internal Medicine in Medical Present Oncology Board Certification in Medical Oncology, U.S. (ABIM) 1997 Board Certification in Medical Oncology, Canada (FRCPC) November, 1994 Fellow of the Royal College of Physicians and Surgeons of Canada, Specialty Certification in Internal Medicine. August, 1994 Diplomate of the American Board of Internal Medicine. (ABIM) July, 1992 Licentiate of the Medical Council of Canada (LMCC). PROFESSIONAL SOCIETIES American Medical Association 1994-present American Society of Hematology 1994-present American Socity of Clinical Oncology Canadian Medical Association Alberta Medical Association COMMITTEES 1999-present Scripps Memorial Hospital, Encinitas. Cancer Committee 2000-present Scripps Memorial Hospital, Encinitas. Pharmacy and Therapeutics Tri-City Hospital, Vista. Blood Transfusion Utilization Committee

4 PUBLICATIONS Frakes, LA., Brehm, TL., Kosty, MP., Miller, WE., McMillan, RL., Madon, J and Meisenberg, BR An All Oral Antiemetic Regimen for Patients Undergoing High- Dose Chemotherapy with Peripheral Blood Stem Cell Transplantation. Bone Marrow Transplantation. 20: Benjamin, L.A., McGarry, R.C. and Hart, D.A Alterations in Plasminogen Activator and Inhibitor Activity During the Differentiation of Human Neuroblastoma Cell Line, SMS-KAN. Cancer Letters, 44(2): Benjamin, L.A., McGarry, R.C. and Hart, D.A Effect of Retinoic Acid on Human Neuroblastoma Cells: Correlation Between Morphological Differentiation and Changes in Plasminogen Activator and Inhibitor Activity. Cancer Chemotherapy and Pharmacology, 25(1): ABSTRACTS Frakes,L., Miller, W., McMillan, R. and Meisenberg, B High-dose Chemotherapy with Peripheral Blood Stem Cell Transplantation for Mantle Cell Lymphoma (MCL). Blood, 88 (suppl 2); abst Meisenberg, B., Frakes, L., Brehm, T., Shmeckel, A., Miller, W., and McMillan,R Single Large Volume Leukapheresis (LVL) after Mobilization with Low-dose Cyclophosphamide, GM-CSF and G-CSF Allows Predictable and Successful Collection of Stem Cells. Blood, 88 (suppl 2); abst Meisenberg, B, Frakes, L., Brehm, T., Schmeckel, A., Miller, W., and McMillan, R Use of G-CSF Given to Allogeneic Donors to Improve CD34 Yields in Bone Marrow Collections and Hasten Engraftment. Blood, 88 (suppl 1); abst Presented in Orlando, Florida. Frakes, L., Kosty, M., Miller, W., McMillan, R., and Meisenberg, B Antiemetic Efficacy During High-Dose Chemotherapy (HDC) with Peripheral Blood Progenitor Cell Transplant (PBPCT): Early Results of a Pilot Study of an All Oral Regimen. Supportive Care in Cancer, 4(3); abst 117. Presented in Toronto, Canada. Frakes, L., Kosty, M., Miller, W., McMillan, R., and Meisenberg, B Early Results of a Pilot Study of an All-Oral Antiemetic Regimen for Patients Undergoing High-Dose Chemotherapy (HDC) with Peripheral Blood Progenitor Cell Transplant (PBPCT). Ann Oncol, 7 (suppl 5); abst 673P. Presented in Vienna, Austria. Lemaire, J., Frakes, L., Pineo, G., Faris, G., Brant, R., and Hull,R Quality Assurance of Heparin Delivery: Introduction of a Heparin Protocol to a Tertiary Care Hospital. Blood, Vol 86:35034.

5 Benjamin, L.A., McGarry, R.C. and Hart, D.A Role of Plasminogen Activators and Inhibitors in Neuroblastoma Cell Differentiation. Presented at the Second Annual Conference in Fibrinolysis, Holland. Benjamin, L.A., Hoffman-Goetz, L Interleukin-1 Activity in Cultured Rat Thymus Cells. Presented at the International Society of Immunology, Toronto, Canada. INIVITED PRESENTATIONS Frakes, L An All Oral Antiemetic Regimen for Patients Undergoing High-Dose Chemotherapy (HDC) with Peripheral Blood Stem-Cell Transplant (PBSCT): Results of a Pilot Study. Hematology/Oncology Fellowship Program in Hematologic Malignancies. Presented in San Diego, CA. Frakes, L An All Oral Antiemetic Regimen for Patients Undergoing High-Dose Chemotherapy (HDC) with Peripheral Blood Stem-Cell Transplant (PBSCT): Results of a Pilot Study. SmithKline Beecham National Oncology Fellows Forum. Presented in Tucscon, Arizona. Frakes, L Antiemetic Therapy for High-Dose Chemotherapy Regimens. Presented at California Society of Health-System Pharmacists Symposium, Los Angeles, CA., and Kytril Investigators Meeting, New York, NY and San Francisco, CA.