Informed Consent. Clinical Information

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1 IRB APPROVED MULTI-MEDIA SYSTEMS, INC. Form Revised March Radcliffe Drive, Chestertown, MD Tel: 866-ILS-1199/ Fax: Clinical Case Report (For Collection of Cancerous Tissue) ILS ID#: (Attach Barcode) Informed Consent I personally informed this patient that a specimen(s) would be collected to be used for research purposes. I reviewed the ILSbio RESEARCH SUBJECT INFORMATION AND CONSENT FORM with the patient and answered any questions the patient had. The patient then signed the consent form as a free and voluntary act. A copy of this informed consent document will be retained at our institution. Name of Physician or Study Coordinator Signature Date Clinical Information GENERAL INFORMATION Date of Birth (mm/dd/yyyy) Height Marital Status Race Temperature Single Married Gender Weight Divorced Widow Blood Pressure Heart Rate Male Female Chief Complaints: HISTORY OF PRESENT ILLNESS Symptoms: Clinical Findings: Performance Scale (Karnofsky Score): 100 Asymptomatic Symptomatic but Fully Ambulatory Symptomatic, in bed less than 50% of day Symptomatic, in bed more than 50% of day, but not bed ridden Bed Ridden PAST MEDICAL HISTORY Diagnosis/Disease/Disorder/Injury Diagnosis Date Treatment Status

2 ILS ID#: (Attach Barcode) OB/GYN HISTORY Menopausal Status Date of First Menses # of Pregnancies Pre-menopausal Peri-Menopausal Post-menopausal Date of Last Menses # of Live Births Birth Control: Condom Oral Contraceptive IUD Hormone Replacement Therapy: SOCIAL HISTORY Occupation: Environmental Hazards: Smoking History Current Status TYPE Packs/day Duration When Quit YES NO (yrs) (yr) Alcohol Consumption Current Status TYPE Drinks/day Duration When Quit YES NO (yrs) (yr) Drug Use Current Status TYPE Frequency Duration When Quit YES NO (yrs) (yr) FAMILY MEDICAL HISTORY Relative Diagnosis Age of Diagnosis LAB DATA Test Result Date Test Result Date HIV : CEA : Hep B : CA 15-3 : Hep C : CA 19-9 : AFP : PSA : : : B/T Cell Markers: DIAGNOSTIC STUDIES Study Results Date Ultrasound X-Ray CT Endoscopy MRI Biopsy 2

3 ILS ID#: (Attach Barcode) CLINICAL DIAGNOSIS Preoperative Clinical Diagnosis Location of Suspected Involved Lymph Nodes Location of Suspected Distant Metastasis Clinical Staging T N M Stage: Date of Diagnosis Treatment Information SURGICAL TREATMENT Procedure Date of Procedure Primary Tumor Organ Detailed Location Size Extension of Tumor x x cm Lymph Nodes Description Location of Lymph Nodes # of Lymph Nodes Palpable, Non-Dissected Lymph Nodes Dissected Lymph Nodes Distant Metastasis Organ Detailed Location Size Surgical Staging T N M Stage: NEOADJUVENT THERAPY (Chemo, Radiation, Immuno, Hormonal, or Molecular) Drug/Treatment Dose Route Frequency Date (mm/dd/yyyy) ADJUVENT THERAPY (Chemo, Radiation, Immuno, Hormonal, or Molecular) Drug/Treatment Dose Route Frequency Date (mm/dd/yyyy) OTHER MEDICATIONS Drug Dose Route Frequency Date (mm/dd/yyyy) 3

4 Pathology Form ILS ID#: (Attach Barcode) Specimen Information Collected by: Date: Time: Preserved by: Date: Time: SPECIMEN TYPE (# of samples provided) Frozen Paraffin Block Blood/Serum/Plasma Slide Diseased Normal Diseased Normal Diseased Normal Diseased Normal Time to LN2 Time to Formalin Time to LN2 min min min PATHOLOGICAL DESCRIPTION Primary Tumor Organ Size Extension of Tumor Distance to NAT x x cm cm Lymph Nodes Location # Examined # Metastasized Distant Metastasis Organ Detailed Location Size Notes: Pathological Staging pt N M Stage: 4

5 Microscopic Description ILS ID#: (Attach Barcode) Histological Pattern Cell Distribution + - Structural Pattern + - Diffuse Streaming Mosaic Storiform Necrosis Fibrosis Lymphocytic Infiltration Palisading Vascular Invasion Cystic Degeneration Clusterized Bleeding Alveolar Formation Myxoid Change Indian File Psammoma/Calcification Cellular Differentiation Squamous + - Adenomatous + - Sarcomatous + - Lymphomatous + - Squamoid Cell Glandular cell Round Cell Large Cell Spindle Cell Cell Stratification Fibroblast Small Cell Keratin Secretion Osteoblast RS Cell/RS Like Desmosome Intracyt. Vacuole Lipoblast Inflam. Cell Pearl Gland formation Myoblast Plasma Cell Cellular Differentiation: Well Moderate Poor Nuclear Appearance Nuclear Atypia: 0 I II III Aniso Nucleosis Hyperchromatism Nucleolar Prominent Multinucleated Giant Cell Mitotic Activity Nuclear Grade: IHC Data Marker Result Value Date ER PR Her-2/neu B-Cell Marker T-Cell Marker Final Pathology Report Histological Diagnosis: Grade: Comments: Principal Investigator Pathologist Date 5

6 ILS ID#: (Attach Barcode) Clinical/Pathological Data Summary This form is to ensure all essential staging information is provided. Please verify that ptnm and pathological stage correspond with staging details. Please make sure all available data is filled in prior to sending specimens. Organ Location within Organ Surgical Procedure Menopause Status (Required for Breast Cancer) Clinical TNM Clinical Stage ptnm Pathological Stage Primary Tumor Size Level or Depth of Invasion Within Organ If T4, Invasion to Which Adjacent Tissue Lymph Node Location # of Lymph Node Examined # of Lymph Nodes Metastasized If M1, Metastasized Organ Principal Investigator Date 6

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