Students 24,639 %Undergraduate 70.4% % postgraduate 29.6% International Students 2491 Citation (scopus) QS-WUR( ) 44,625

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1 Rosline Hassan Professor in Haematologist Deputy Dean of Research, School of Medical Sciences, Universiti Sains Malaysia, Kelantan, Malaysia roslin@usm.my

6% International Students 2491 Citation (scopus) QS-WUR(2010-2014) 44,625 Research paper (Data from scopus

2 Universiti Sains Malaysia USM 2 nd oldest university in Malaysia Established in 1969 (45 years) Students 24,639 %Undergraduate 70.4% % postgraduate 29.6% International Students 2491 Citation (scopus) QS-WUR( ) 44,625 Research paper (Data from scopus for 5-years) 15,153 Faculty 2,152 *Selected to implement Accelerated Program of Excellent (APEX) University in the country A premium Research University Strong governance & autonomy

Malay - 1,561,400 Chinese - 54,000 Indian - 4700

3 Background of Kelantan Population : Kelantan - 1,691,900 Kota Bharu - 552,300 Races in Kelantan- Malay - 1,561,400 Chinese - 54,000 Indian Others - 20,100 5 Main Cause of Death in Kelantan 3

4 Non-communicable Disease Prevalence of Diabetes in Kelantan 10 Most common cancer in Kelantan 4

5 Health Campus 1990 School of Medical Sciences : 1979 Hospital Universiti Sains Malaysia (1983) 1983 A few centre of excellence services in HUSM *Cardiology *Cardiothoracic Surgery * Burn and Reconstructive Surgery *Neurosciences *National Tissue Banking *Interventional Radiology

6 Research Cluster : School of Medical Sciences Research Cluster Sub-cluster Research Cluster Sub-cluster Cancer & Oncology Prof. Rosline Hassan roslin@usm.my Prof. Nik Soriani Yaacob niksoriani@usm.my Reconstructive Sciences, Tissue Bank & Biomaterials Prof. Ahmad Sukari Halim ashalim@usm.my Assoc. Prof. Dr. Suzina Sheikh Ab. Hamid suzina@usm.my Leukaemia Solid tumour :Breast CA Colorectal CA;Cervical CA Osteosarcoma Natural Anticancer Identification Mechanism of Action Cancer Genetics Quality of life Biological & Synthetic Biomaterials Reconstructive Cleft Lip & Palate Deformities Tissue Engineering & Stem Cells Biocompatibility Burn Wound Wound Healing & Scar Genetics & Genomics Prof. Zilfalil Alwi zilfalil@usm.my Prof. Hans Luc Aster Van Rostenberghe hansvro@usm.my Population Genetic Cancer Cytogenetic Molecular-Cytogenetic Genetic Epidemiology of Cancer Human Genetic Disorders Ethics in Human Genetics Human Variome Project

7 Research Cluster : School of Medical Sciences Research Cluster Sub-cluster Research Cluster Sub-cluster Pharmacogenetics& Toxicology Prof. Dr. Gan Siew Hua shgan@usm.my Dr. Ruzilawati Abu Bakar ruzila@usm.my Lifestyle Diseases & Metabolic Syndromes Prof. Abdul Aziz Al-Safi Ismail aziz.alsafi@usm.my Dr. Wan Mohd Izani Wan Mohamad izani@usm.my Brain Sciences, Neurosciences & Mental Health Assoc Prof Dr. Muzaimi Mustapha mmuzaimi@usm.my Dr. Maruzairi Husain drzairi@usm.my Pharmacogenetics Pharmacokinetics Drug Analysis Type 1 & 2 Diabetes Mellitus Hypertension Cardio Vascular Diseases Hyperlipidemia Obesity Metabolic Syndrome Nephrology Stem Cell Biology Disease Mechanisms & Therapeutic Modalities Neurophysiology Neurogenetics Cognitive Neuroscience Community Mental Health Transcultural Psychiatry Child Psychiatry & Psychogeriatic Traditional & Complementary Medicines Prof. Siti Amrah Sulaiman sbsamrah@usm.my Dr. Mahaneem Mohamed mahaneem@usm.my Community & Public Health Prof. Shaiful Bahari Ismail shaifulb@usm.my Assoc. Prof. Dr. Aziah Daud aziahkb@usm.my Apitherapy Honey Propolis & Bee-Pollen Acupuncture Herbal Medicine Cupping Natural Products Epidemiology Occupational Health Health Management Environmental Health Nutrition Family Health Smoking Drug Addiction Men s Health Geriatric Healthy Lifestyle Promotion Care of Disabled IT & Health

8 Research Cluster : School of Medical Sciences Research Cluster Reproductive, Women & Children Health Prof. Nik Hazlina Nik Hussain hazlinakck@usm.my Assoc Prof. Dr. Noraida Ramli aidaramli@usm.my Critical & Surgical Care Assoc. Prof. Dr. Nik Hisamuddin Nik Ab Rahman hisamuddin@usm.my Dr. Andee Dzulkarnaen Zakaria andee@usm.my Sub-cluster Reproductive Endocrinology & Infertility Violence & Gender Maternal, Perinatal & Adolescent Health Feto-Maternal Oral Health Children& Adolescents with Disability In-Vitro Fertilization Trauma & Injury Prevention Acute Pain Mx Hyperbaric Medicine Pre-Hospital Care Resuscitation Neuroemergencies Imaging Care Surgical Intervention Research Cluster Visual Sciences Assoc. Prof. Dr. Liza Sharmini Ahmad Tajuddin liza@usm.my Assoc. Prof. Dr. Shatriah Ismail shatriah@usm.my Airways, Head & Neck Sciences Assoc. Prof. Dr. Baharudin Abdullah baharudin@usm.my Assoc. Prof. Dr. Irfan Mohamad irfankb@usm.my Life Sciences Prof. Aida Hanum Ghulam Rasool aidakb@usm.my Prof. Hasnan Jaafar hasnan@usm.my Sub-cluster Ocular & Vascular Patho Glaucoma Research Ocular Imaging Ocular Genetics Refractive & Ocular Retinal Research Children Visual Research Neurophthalmic Ophthalmic Epid.gy Allergy & Rhinology Airways Laryngology Ear & Hearing Head & Neck Sciences Macro, Micro & Endothelial Function Oxidative Stress Stem Cell & Cell Culture Obesity Blood Related Health

9 Research Cluster Total Grant (No.) Total Fund (RM) Total Publication Cancer & Oncology 39 4,394, Reconstructive Sciences, Tissue Bank & Biomaterials Medical Technology, Infectious & Immunological Diseases Sport 3/3/2016 Sciences* 40 2,679, ,222, ,092, Genetics & Genomics 55 6,363, Pharmacogenomics & Toxicology 9 817, Lifestyle Diseases & Metabolic Syndrome ,838, Brain Sciences, Neurosciences & Mental Health 61 3,064, Traditional & Complementary Medicines 75 5,581, Community & Public Health 130 6,848, Reproductive, Women & Children Health 55 1,363, Critical & Surgical Care 58 1,850, Visual Sciences 24 1,173, Airways, Head & Neck Sciences 24 1,552, Life Sciences 130 5,392, Medical Education & Statistics ,

10 The Quantum Grants in Various Research Clusters ( )

Cancer Research Usage of herbal supplement amongst Unravelling the genetic and epigenetic breast cancer survivor Contact:Dr Rosnani Zakaria : email : rosnani@usm.

our observationour women tend to use herb supplement at any time during their course of illness, believing that this herbal supplement will help cure the disease and improving their quality of life.

11 Cancer Research Usage of herbal supplement amongst Unravelling the genetic and epigenetic breast cancer survivor Contact:Dr Rosnani Zakaria : rosnani@usm.my Dr Juliawati Muhammad;Dr Imran Ahmad;Department of Family Physician In breast cancer pts, vit A, D proven to reduce risk of developing breast ca in pre and post menopausal but in Malaysia, from our observationour women tend to use herb supplement at any time during their course of illness, believing that this herbal supplement will help cure the disease and improving their quality of life. Planned collaborative research : to investigate the common herbs which these patients used andits chemical properties : proposed to collaborate with Dr Pete Monk, University of Sheffield Futher study is to evaluate how does this affecting their quality of life and recurrence rate. basis of Acute Promyelocytic leukemia Contact : Prof Rosline Hassan, roslin@usm.my Department Hematology Almost Completed study: mirna expression APL Normal 12 most statistically significantly differentially expressed genes in APL at diagnosis and show response to ATRA in patients who survive more than 5 years Planned collaborative reearch: correlate the mirna,gene expression and survival Functional analysis by gene editting Translational research members: Dr. Wong Kah Keng, Imilia Ismail

12 Cancer Research PJ Brown*, KK Wong*, SL Felce, et al FOXP1 suppresses immune response signatures and MHC class II expression in activated B-celllike diffuse large B-cell lymphomas. ; Leukemia Oct 26. doi: /leu [Epub ahead of print] (*shared-first author) (IF: ) Exploration of biomarkers in cancer medicine Researcher name : Prof Dr. RAVINDRAN ANKATHIL Phone : (Office ) / ( HP ) rankathil@hotmail.com / aravi@usm.my My area of research is focused on exploration of genetic and epigenetic biomarkers that can be used in cancer ( specifically breast cancer, colorectal cancer and chronic myeloid leukemia ) for 1. Risk assessment 2. Specific diagnosis 3. Prognosis and treatment predictions 4. Pharmacokinetics 5. Monitoring treatment response and 6. Predicting or monitoring recurrence Identification of novel/specific protein markers in cancers, and to target these proteins with specific inhibitors. Research by Dr. Wong Kah Keng (DPhil, Oxon) Address: Department of Immunology, School of Medical Sciences, Health Campus, Universiti Sains Malaysia, Kubang Kerian, Kelantan. Tel: / ; kahkeng@usm.my Disease of interest: Diffuse large B-cell lymphoma (DLBCL); Haematological malignancies; Breast cancer or cancer in general. Methodologies: Bioinformatics (e.g. expression and functions prediction of a gene/protein), microarrays (GSEA, R), lentivirusmediated knockdown of gene expression, therapy (novel inhibitors targeting the protein of interest) These biomarkers might be able to facilitate the molecula r definition of cancer, provide information about course patient management towards personalized onco-therapy. References: KK Wong, DM Gascoyne, PJ Brown, et al. Reciprocal expression of the endocytic protein HIP1R and its repressor FOXP1 predicts outcome in R-CHOP-treated diffuse large B-cell lymphoma patients. Leukemia (2), (IF: )

13 Community & Public Health Epidemiology of Non-communicable Disease Contact : Associate Prof Dr Kamarul Imran Musa (drkamarul@usm.my, , School of Medical Sciences, USM, Kubang Kerian, Kelantan) Planned Collaborative Research A population-based study on stroke in an Asian pop Objectives Spatial mapping of stroke incidence and/or prevalence, risk-factors, outcomes and resources Population of interest: Population in the East-coast of Peninsular Malaysia Members : MALAYSIA Prof Dato Jafri Malim, Assoc Prof Wan Mohd Zahiruddin UK CHICAS (Lancaster University) Dr Thomas Keegan, Distinguished Prof Peter Diggle Completed study (selected) Metabolic syndrome (Metabolic syndrome study in Malaysia MSSM) population-based multi-centre study (4100 patients) My current work Stroke epidemiology A hospital-base case-control (3000 patients), fatality and functional outcome in Kelantan, Malaysia (with Lancaster University) Obesity and diabetes among Malaysian population Contact :Assoc Prof ROHANA ABDUL JALIL, PhD; Department of Community Medicine; School of Medical Sciences, USM, Kubang Kerian, Kelantan; rohanajalil@usm.my or rohanajalil@hotmail.com Planned Collaborative research obesity & diabetes among Malaysian population among adult ages 50 to 60 years old research in obesity and diabetes among Malaysian population, in particular, nutrition and lifestyle, social and genetic factors as proposed by David Barker Completed study social determinants and dietary factors related with obesity and diabetes in relation to socioeconomic status, rural and urban differences and ethnicity differences Behavioural intervention through physical activity and nutrition among rural obese population experience :Principal Investigator in Global Nutrition and Epidemiological Transition Group (GNET Malaysia) with 12 countries in reducing burden of obesity and diabetes by improving carbohydrate quality among Malaysian population.

14 Thank You Transforming Higher Education For A Sustainable Tomorrow

HONEY - THE EMERGENCE OF FOR HEALTH AND DISEASE

HONEY - THE EMERGENCE OF FOR HEALTH AND DISEASE HONEY - THE EMERGENCE OF POSITIVE SCIENTIFIC EVIDENCE FOR HEALTH AND DISEASE Siti Amrah Sulaiman Head Traditional & Integrative Medicine Cluster School of Medical Sciences Health Campus, Universiti Sains