Breast Cancer Services in Germany
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1 Breast Cancer Services in Germany COUNTRY DELEGATES WORKSHOP Ispra (VA) - 13 and 14 March 2013 Karen Budewig, Federal Ministry of Health, Germany Vanessa Kääb-Sanyal, Mammography-Screening-Program, Germany Simone Wesselmann, German Cancer Society, Germany
2 Breast cancer services in Germany Breast Cancer Centers Evidence based guideline for Breast Cancer Mammography Screening Cancer registries
3 Breast cancer services in Germany Breast Cancer Centers Evidence based guideline for Breast Cancer Mammography Screening Cancer registries
4 Mammography- Screening Germany is made up of 16 Länder (federated states) Relevant Legislation: National guidelines for the screening-program but higher ranking legislation on regional (mainly state) level, regarding: Data protection (privacy) Registration of address Cancer registration Public health care provision Radiation Control Regulations Source:
5 Mammography- Screening Federal level (KoopG + 5 RC) Supraregional (5 RC each with SE) Reference Centres (RC) Evaluation, Training, Quality Assurance State level Kooperationsgemeinschaft (KoopG) Evaluation, Organization, Coordination Invitation Centres Written invitation Population Registries Ep. Cancer Registry Association of SHI Physicians Statutory Health Insurance Regional level (94 SU each with ~120 thousand eligible women) Screening Unit (SU) Organisation, Controlling, QM Mammography Unit (MU) Pathology Breast Cancer Centres Assessment Unit (AU) Non-invasive & minimal invasive (Biopsy) MU MU
6 Mammography- Screening Mammography-Screening-Program in Germany: Population based: all women from 50 to 69 ( >10 million) 24-month interval Personal written invitation with appointment (time & place) based on population registries Service only within special certified units with trained personnel (radiographer & physicians) Extensive quality control and management system Continuous evaluation of process and performance indicators (including linkage with cancer registries)
7 Mammography- Screening Invitation Written invitation with time and place Mammography Exam 4 Mammograms: each side in two projections (cc & mlo) Non-invasiv Assessment Participation Double Reading blinded double reading, if needed consensus meeting positive ~54% 100% ~5% negative Clinical assessment, additional mammography, ultrasound positive ~1,5% Minimal-invasiv auffällig (ca. 6%) Assessment (Biopsy) Tissue sample with histological diagnoses Pre-surgical multi disciplinary meeting Radiologist, pathologist, surgeon Surgery/Therapy Breast Cancer Centre positive ~7,6 Post-surgical multi disciplinary meeting Radiologist, pathologist, surgeon
8 Basic Specifications Premises and technical equipment Confirmation of qualification Special trainings Hospitations Reading test Minimal number of cases Supervision (starters) Developement of qualification Special trainings Reading test Sampling inspections Minimal number of cases Extensive physical technical quality assurance & management Quality Assurance and Management Process monitoring Double Reading Multi disciplinary meetings Consesus meeting Pre- and post-surgical meeting Internal quality management, methods for self- testing including expert consultation with RC Diagnostic immage quality Reading quality Biopsy quality Histopathological QM Asessment QM Selected set of performance indicators to monitor the entire screening process Auditing of Results Regular certification (with respect to structure, process and results in perfomance and surrogat indicators) every 30 months Linkage with cancer registries to identify intervall cancers Regular monitoring and public report of the Quality assurance measurements by KoopG Regular evaluation of and report on outcome of screening program (perfomance and surrogate indicators) by KoopG
9 Mammography- Screening Surrogate and Performance Indicators Eligible population Invitation rate Participation rate Recall rate Breast cancer detection rate Proportion of in-situ screen-detected cancers (DCIS) Proportion of invasive screen-detected cancers Proportion of invasive cancer 10 mm Proportion of invasive cancer < 15 mm Proportion of invasive node-negativ cancers Proportion of invasive cancers of stage II+ Positive predictive values Proportion of repeated screening examination Proportion of women attending assessment Early recall rate Proportion of women referred to biopsy Benign to malignant biopsy ratio Biopsies with insufficient results Pre-surgical histological confirmations Time between screening exam and notification on result Time between notification on result and offered assessment Time between assessment and notification on result Breast cancer incidence in target population Breast cancer mortality in the target population Interval cancer rate 1st and 2nd year & classification of interval cancers
10 Breast cancer services in Germany Breast Cancer Centers Mammography Screening Cancer registries
11 Breast Cancer Centers Definition: A network of qualified and jointly certified multidisciplinary and cross-sectoral [...] facilities, that [...] represent the entire supply chain for patients [...]. National Cancer Plan, Germany
12 Breast Cancer Centers Obligatory facilities within the network: gynecology, radiotherapy, pathology, radiology, medical oncology, nursing, general practitioners, mammography screening, genetic counseling, psycho-oncology, social services, physiotherapy, palliative care, pain management, rehabilitation, cancer registries and self-help group
13 Breast Cancer Centers General Practitioners Genetic counseling Cancer registries Palliative care Rehabilitation Self-help group Mammography Screening Radiology Pathology Psycho-oncology Social services Gynecology Nursing Radiotherapy Medical oncology
14 Breast Cancer Centers State : 212 certified Breast Cancer Centers nationwide In these Centers were patients with the initial diagnosis of breast cancer treated in 2012 ( = 87.9% of incident breast cancer patients in Germany)
15 Breast Cancer Centers Certification of Breast Cancer Centers Catalog of requirements based on: Requirements + Quality Indicators for the interdisciplinary, multi-professional and trans-sectoral cooperation Requirements + Quality Indicators for evidence-based treatment of patients transferred from the: German Guideline Program in Oncology (GGPO) Audit 1/year Auditors: Clinically active oncology specialists with training for certification Accredited certification institute: OnkoZert Certificate of the German Cancer society
16 Evidence based guideline for Breast Cancer German Guideline Program in Oncology (GGPO) 2 evidence-based guidelines for breast cancer in Germany : Early detection Diagnostic, therapy and follow-up Last Update: 2008 Last update: 2012
17 Breast Cancer Centers Certification of Breast Cancer Centers Catalog of requirements based on: Requirements + Quality Indicators for the interdisciplinary, multi-professional and trans-sectoral cooperation Requirements + Quality Indicators for evidence-based treatment of patients transferred from the: German Guideline Program in Oncology (GGPO) Audit 1/year Auditors: Clinically active oncology specialists with training for certification Accredited certification institute: OnkoZert Certificate of the German Cancer society
18 Quality Indicators for Breast Cancer Centers: No. 1: Postoperative tumor conference No. 2: Pretherapeutic tumor conference No. 3: Tumor conference at local recurrence / metastasis No. 4.1/2: Recommended/Performed Radiation therapy after breast-conserving therapy No. 5.1/2: Recommended/Performed Radiation therapy after breast-conserving therapy for carcinoma in situ No. 6.1/2: Recommended/Performed Radiation therapy after mastectomy No. 7.1/2: Recommended/Performed chemotherapy in receptor negative findings No. 8.1/2: Recommended/Performed chemotherapy in receptor pos. and node-pos. findings No. 9.1/2: Recommended/Performed endocrine therapy in receptor positive findings No. 10.1/2: Recommended/Performed antibody therapy in HER2 pos. findings No. 11: Psycho-oncological care No. 12: Social services counseling No. 13: Proportion study patients No. 14: Preoperative histological confirmation No. 15: Primary breast cancer cases No. 16: Breast-conserving surgery for pt1 No. 17: Number of mastectomies No. 18: DCIS at primary surgery (ptis) No. 19: Determining nodal status at invasive breast cancer No. 20: Exclusive sentinel lymph node removal (SLNE) at pt1 and pn0 No. 21: Intraoperative sample radiography/sonography No. 22: Revision surgery No. 23: Postoperative wound infection No. 24: Breast Reconstruction No. 25: Indication of resection margin and safe distance
19 Quality Indicators for Breast Cancer Centers: No. 1: Postoperative tumor conference No. 2: Pretherapeutic tumor conference No. 3: Tumor conference at local recurrence / metastasis No. 4.1/2: Recommended/Performed Radiation therapy after breast-conserving therapy No. 5.1/2: Recommended/Performed Radiation therapy after breast-conserving therapy for carcinoma in situ No. 6.1/2: Recommended/Performed Radiation therapy after mastectomy No. 7.1/2: Recommended/Performed chemotherapy in receptor negative findings No. 8.1/2: Recommended/Performed chemotherapy in receptor pos. and node-pos. findings No. 9.1/2: Recommended/Performed endocrine therapy in receptor positive findings No. 10.1/2: Recommended/Performed antibody therapy in HER2 pos. findings for the No. 11: Psycho-oncological care No. 12: Social services counseling No. 13: Proportion study patients No. 14: Preoperative histological confirmation No. 15: Primary breast cancer cases No. 16: Breast-conserving surgery for pt1 No. 17: Number of mastectomies No. 18: DCIS at primary surgery (ptis) No. 19: Determining nodal status at invasive breast cancer No. 20: Exclusive sentinel lymph node removal (SLNE) at pt1 and pn0 No. 21: Intraoperative sample radiography/ sonography No. 22: Revision surgery No. 23: Postoperative wound infection No. 24: Breast Reconstruction No. 25: Indication of resection margin and safe distance Quality Indicators interdisciplinary, multi-professional cooperation
20 Quality Indicators for Breast Cancer Centers: No. 1: Postoperative tumor conference No. 2: Pretherapeutic tumor conference No. 3: Tumor conference at local recurrence / metastasis No. 4.1/2: Recommended/Performed Radiation therapy after breast-conserving therapy No. 5.1/2: Recommended/Performed Radiation therapy after breast-conserving therapy for carcinoma in situ No. 6.1/2: Recommended/Performed Radiation therapy after mastectomy No. 7.1/2: Recommended/Performed chemotherapy in receptor negative findings No. 8.1/2: Recommended/Performed chemotherapy in receptor pos. and node-pos. findings No. 9.1/2: Recommended/Performed endocrine therapy in receptor positive findings No. 10.1/2: Recommended/Performed antibody therapy in HER2 pos. findings No. 11: Psycho-oncological care No. 12: Social services counseling No. 13: Proportion study patients No. 14: Preoperative histological confirmation No. 15: Primary breast cancer cases No. 16: Breast-conserving surgery for pt1 No. 17: Number of mastectomies No. 18: DCIS at primary surgery (ptis) No. 19: Determining nodal status at invasive breast cancer No. 20: Exclusive sentinel lymph node removal (SLNE) at pt1 and pn0 No. 21: Intraoperative sample radiography/sonography No. 22: Revision surgery No. 23: Postoperative wound infection No. 24: Breast Reconstruction No. 25: Indication of resection margin and safe distance Quality Indicators from the evidence based guideline
21 Quality Indicators for Breast Cancer Centers: No. 1: Postoperative tumor conference No. 2: Pretherapeutic tumor conference No. 3: Tumor conference at local recurrence / metastasis No. 4.1/2: Recommended/Performed Radiation therapy after breast-conserving therapy No. 5.1/2: Recommended/Performed Radiation therapy after breast-conserving therapy for carcinoma in situ No. 6.1/2: Recommended/Performed Radiation therapy after mastectomy No. 7.1/2: Recommended/Performed chemotherapy in receptor negative findings No. 8.1/2: Recommended/Performed chemotherapy in receptor pos. and node-pos. findings No. 9.1/2: Recommended/Performed endocrine therapy in receptor positive findings No. 10.1/2: Recommended/Performed antibody therapy in HER2 pos. findings No. 11: Psycho-oncological care No. 12: Social services counseling No. 13: Proportion study patients No. 14: Preoperative histological confirmation No. 15: Primary breast cancer cases No. 16: Breast-conserving surgery for pt1 No. 17: Number of mastectomies No. 18: DCIS at primary surgery (ptis) No. 19: Determining nodal status at invasive breast cancer No. 20: Exclusive sentinel lymph node removal (SLNE) at pt1 and pn0 No. 21: Intraoperative sample radiography/ sonography No. 22: Revision surgery No. 23: Postoperative wound infection No. 24: Breast Reconstruction No. 25: Indication of resection margin and safe distance Quality Indicators for the expertise of the main partners in the network
22 Breast Cancer Centers Annual evaluations of the quality indicators for all centers Personalized reports for the centers Reports download: Download Jahresbericht 2012
23 Breast Cancer Centers Report 2012 with the results of: 206 Centers Patients with the initial diagnosis of breast cancer
24 Breast Cancer Centers
25 Breast cancer services in Germany Breast Cancer Centers Mammography Screening Cancer registries
26 Cancer registries The epidemiological and clinical cancer registries are obligate partners in the breast cancer centers: Data for quality indicators Outcome data (overall survival, relapse-free survival) Epidemiological cancer registries in every federal state (population based) Clinical cancer registries (52, not regular population based until now)
27 Cancer registries The epidemiological and clinical cancer registries are obligate partners in the breast cancer centers: Data for quality indicators Outcome data (overall survival, relapse-free survival) Epidemiological cancer registries in every federal state (population based) Clinical cancer registries (52, not regular population based until now)
28 Cancer registries (One) Result of the National Cancer Plan: In January and March 2013 the German Parliament (Bundestag) and the Chamber of the Federal Laender (Bundesrat) have passed the law on "the further development of the early detection of cancer and quality assurance through clinical cancer registries"
29 Breast cancer services in Germany Breast Cancer Centers Evidence based guideline for Breast Cancer Mammography Screening Cancer registries
30 Thank you!
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