It does not contain all the available information. It does not take the place of talking to your doctor or pharmacist.
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1 CISPLATIN INJECTION CONSUMER MEDICINE INFORMATION What is in this leaflet This leaflet answers some common questions about Cisplatin Injection. It does not contain all the available information. It does not take the place of talking to your doctor or pharmacist. All medicines have benefits and risks. Your doctor has weighed the risks of you taking Cisplatin Injection against the benefits this medicine is expected to have for you. If you have any concerns about taking this medicine, ask your doctor or pharmacist. Keep this leaflet. You may need to read it again. What Cisplatin Injection is used for Cisplatin belongs to a group of anticancer medicines known as the platinum complexes. Cisplatin works by preventing the growth of cancer cells and eventually destroying them. It is CISPLATIN INJECTION 1
2 used for cancer of the ovary, testis, bladder and also head and neck cancer. Ask your doctor if you have any questions about why this medicine has been prescribed for you. Your doctor may have prescribed it for another purpose. This medicine is available only with a doctor's prescription. Before you are given Cisplatin Injection When you must not be given it Do not use Cisplatin Injection if: you have an allergy to cisplatin, carboplatin or other medicines containing platinum you have an allergy to any of the ingredients listed at the end of this leaflet you have kidney disease or poor kidney function you have a low blood count you have hearing problems Do not use this medicine if you are pregnant or planning to become pregnant. It may affect the developing baby. CISPLATIN INJECTION 2
3 Birth control should be used during treatment with Cisplatin. You must tell your doctor immediately if you think you are pregnant. Cisplatin may have a prolonged effect on fertility in males and females. Your doctor should discuss this issue with you before you begin therapy with Cisplatin. Do not breastfeed if you are using this medicine. The possible harmful effects to the infant are unknown, so breastfeeding is not recommended while you are receiving Cisplatin. If you are not sure whether you should be given Cisplatin, talk to your doctor. Before you are given it Tell your doctor if you have any allergies to any medicines, foods, preservatives or dyes. Tell you doctor if you are pregnant or plan to become pregnant. Tell your doctor if you are breastfeeding or plan to breastfeed. Tell your doctor if you have or have had any medical conditions, especially the following: any sort of infection, e.g., sinusitis, tooth abscess, etc CISPLATIN INJECTION 3
4 abnormal or heavy bleeding bleeding gums unusual tiredness severe nausea and vomiting numbness or weakness of the arms and legs dizziness or being light-headed, especially on standing up problems with your sight fits muscle weakness Taking other medicines Tell your doctor if you are taking any other medicines, including any that you buy without a prescription from your pharmacy, supermarket or health food shop. Some medicines and Cisplatin may interfere with each other. These include: other anticancer drugs antibiotics fluid tablets (diuretics) vaccinations CISPLATIN INJECTION 4
5 You may need different amounts of your medicines or you may need to take different medicines. Your doctor will advise you. How Cisplatin Injection is given Cisplatin is given by a slow injection into a vein. Cisplatin must only be given by a doctor or nurse. Your doctor will decide what dose, how often and how long you will receive it. This depends on your condition and other factors, such as your weight, age, blood tests, how well your kidneys, liver and ears are working, and whether or not other medicines are being given at the same time. Additional fluid is given before and after your dose of Cisplatin. This is to make sure that you do not lose too much water and cause problems with your kidneys. If you are given too much (overdose) Overdose is unlikely as treatment is given in hospital under the supervision of a doctor. However, if you are given too much cisplatin, you may experience some of the effects listed under "Side Effects" below. Ask your doctor if you have any concerns. Your doctor has information on how to recognise and treat an overdose. CISPLATIN INJECTION 5
6 While you are being treated with Cisplatin Things you must do Keep all of your doctor's appointments so that your progress can be checked. You will also have blood tests to check for side effects. Tell any other doctors, dentists and pharmacists who treat you that you are using this medicine. If you become pregnant while using this medicine, tell your doctor immediately. Side effects Tell your doctor, nurse or pharmacist as soon as possible if you do not feel well while you are being given Cisplatin Injection. Like other medicines, Cisplatin can cause some side effects. If they occur, most are likely to be minor or temporary. However, some may be serious and need medical attention. Tell your doctor immediately if you notice any of the following: nausea or vomiting flushing, swelling of the face, wheezing, fast heartbeat, a rash, dizziness or feeling light-headed CISPLATIN INJECTION 6
7 hearing loss or ringing in the ears (tinnitus) blurred vision, changes in colour or blindness muscle cramps or twitching muscle aches or pains tingling or a loss of sensation in the hands or feet problems with movement or reduced reflexes, and leg weakness slurred speech and loss of taste and memory irregular and/or rapid heart beat shaking or tremors, foot spasms pain or redness at site of injection bleeding, unusual bruising, bleeding gums, blood in the urine or stools, or pinpoint red spots reduced urination, swelling of feet or lower legs fever and chills, sore throat, sweats or feel generally unwell tiredness hair loss, especially of the scalp Other side effects not listed above may also occur in some patients. CISPLATIN INJECTION 7
8 Tell your doctor if you notice any other effects. Some side effects may only be seen by your doctor. Product Description What it looks like Cisplatin Injection is a clear, pale yellow solution in a plastic vial. Ingredients Cisplatin Injection contains cisplatin, sodium chloride and mannitol in Water for Injections. It does not contain a preservative. Supplier Cisplatin is supplied in Australia by: Pfizer Australia Pty Ltd ABN Wharf Road West Ryde NSW 2114 Toll Free Number: It is supplied in New Zealand by: CISPLATIN INJECTION 8
9 Pfizer New Zealand Ltd PO Box 3998 Auckland Toll Free Number: Australian registration numbers AUST R 11349: 10 mg in 10 ml (Not currently marketed) AUST R 49301: 50 mg in 50 ml AUST R 49302: 100 mg in 100 ml Date of preparation This leaflet was prepared in May CISPLATIN INJECTION 9
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