TB Program and Epidemic aka B2B
|
|
- Bertram Richards
- 5 years ago
- Views:
Transcription
1 TB Program and Epidemic aka B2B Nulda Beyers On behalf of DTTC BOD Workshop 30 September2013
2 Trend in tuberculosis incidence, selected countries in Africa Rate per 100, South Africa Zambia Malawi Mozambique Tanzania Calendar year Estimates from the WHO Global Report
3 The Universe of TB Where are the missing cases? Global % All cases 100 Not accessing services Accessing services but not examined Diagnosed not treated (initial default) Treated in other sectors Recorded unreported 4 Reported 61
4 Exit study - Aim To determine how many adults access healthcare facilities but are not diagnosed with TB, in facilities where TB diagnosis depends on passive case finding.
5 Exit study - results 4686 exits 665/4686 (14%) consented 1122/4686 (24%) on treatment or fetched meds 2899/4686 (62%) declined 423/665 (64%) symptomatic 242/665 (36%) asymptomatic
6 Exit study - results 423/665 (64%) symptomatic 36/423 (9%) accessed b/o chest complaints 387/423 (91%) did not access b/o chest complaints 3/36 (8%) were asked about chest complaints 13/387 (3%) were asked about chest complaints 1/3 (33%) was asked for sputum 3/13 (23%) were asked for sputum 1/1 gave a sputum and had return date 1/3 (33%) gave a sputum and had return date
7 Exit study - results 423 symptomatic 21/423 (5%) TB Cases 385/423 (91%) not TB Cases 17/477 (4%) missing data 0/21 accessed because of chest complaints 0/21 asked about chest complaints 0/21 asked to give a sputum
8 Exit study - conclusion Many patients with infectious TB access healthcare, but are not diagnosed. Intensified case finding must start within the facility. B2B
9 Initial Default (Initial Loss to Follow-up) Stellenbosch District (9 fixed clinics, 4 mobile clinics) 64/369 (17%) TB suspects with 2 positive smears not on treatment Ravensmead and Uitsig 58/373 (16%) initial defaulters (2 smear+, or culture+): 24% died 45% not found (address!!) results often not available or not given to the patient culture result takes long time IJTLD 2008; 12(8): IJTLD 2008; 12(7):
10 Initial Loss to Follow-up 5 other provinces (122 clinics) - 24% ILTF IJTLD 2013; 17(5): 603
11 Conslusion Many patients diagnosed with TB but do not start treatment B2B
12 Drug Resistant TB Clinical course of patients using routine data. To determine the progression from drug sensitive to drug resistant (MDR and XDR) by combining clinical and bacteriological data.
13 Drug Resistant TB Methods Database (routine TB register data) Sample bank Additional laboratory tests for Drug Resistance Home visits and follow up
14 Drug Resistant TB Retreatment after default Historical cohort 2,136 smear positive cases ( ) were treated again for TB Re-treatment rate in defaulters compared to retreatment rate in successfully treated cases (95% CI: ) per 100 PY after default 2.09 (95% CI: ) per 100 PY after cure. 27.9% (95% CI: 22.8% 33.8%) of defaulters were treated again for smear-positive TB. PLoS One. 2012;7(9):e45724.
15 Evolution of Drug Resistant TB Retreatment after default 50% 45% Proportion with smear+ recurrence 40% 35% 30% 25% 20% 15% 10% 5% 0% Time since end of the previous episode (years) After treatment default, initial smear 3+ After treatment default, initial smear 1+ or 2+ After cure/completion, initial smear 3+ After cure/completion, initial smear 1+ or 2+ PLoS One. 2012;7(9):e45724.
16 Drug Resistant TB Default after previous treatment Same cohort (141 treatment defaulters) Default rates in new cases compared to default rate in previously treated (OR) 1.79 (95% CI ) after previous treatment success 6.18 (95% CI ) after previous default 9.72 (95% CI ) after previous failure Int J Tuberc Lung Dis. 2012; 16(8):
17 Drug Resistant TB Default after previous treatment Other risk factors: Male (P=0.008), Age years (P=0.02) Positive sputum-smear (P=0.02) Int J Tuberc Lung Dis. 2012; 16(8):
18 Drug Resistant TB Risk of developing MDR TB rpob mutant (MDR) present Total Number % P- value All cases 1, Number of previous episodes > <0.01
19 Drug Resistant TB Risk of developing MDR TB rpob mutant (MDR) present Category of episode Total Number % P- value New 1, After cure After completion After default <0.01 Too few cases after failure or unknown for analysis
20 Drug Resistant TB Conclusion High rate of retreatment after default High rate of default after previous treatment High rate of MDR after retreatment, especially smear positive B2B
21 Amplification of MDR/XDR TB in children
22 Family One A1 A2 A3 Family One Uncle s mother Code A1 Uncle A2 Index child A3 Death Treatment for drug susceptible TB Treatment for MDR TB Treatment for XDR TB TB with no treatment Emerg Infect Dis. 2012;18(8):1342-5
23 Family Two B3 B1 B4 B5 B2 Family Two Oldest brother B1 Sister B2 Mother B3 Other brother B4 Index child B5 Death Treatment for drug susceptible TB Treatment for MDR TB Treatment for XDR TB TB with no treatment Emerg Infect Dis. 2012;18(8):1342-5
24 Conclusion Amplification Potential for resistance to be both transmitted and amplified within families Contact management Diagnose and treat and prevent retreatment B2B
25 The Universe of TB Where are the missing cases?
26 Exit: Final Conclusion = B2B Many patients with infectious TB access healthcare, but are not diagnosed. Intensified case finding must start within the facility. Initial Loss to Follow-up Many people with infectious TB access health care and are diagnosed, but do not start treatment
27 Final Conclusion = B2B MDR and retreatment High rate of retreatment after default High rate of default after previous treatment High rate of MDR after retreatment, especially in S+ Diagnose and treat and prevent retreatment Resistance transmitted and amplified within families Contact management
28 Acknowledgements People in communities City of Cape Town Health Directorate Western Cape Government, Department of Health TREAT TB, USAID, Union
UvA-DARE (Digital Academic Repository) Tuberculosis case finding in South Africa Claassens, M.M. Link to publication
UvA-DARE (Digital Academic Repository) Tuberculosis case finding in South Africa Claassens, M.M. Link to publication Citation for published version (APA): Claassens, M. M. (2013). Tuberculosis case finding
More informationEPIDEMIOLOGY OF TUBERCULOSIS AND the IMPACT ON CHILDREN
EPIDEMIOLOGY OF TUBERCULOSIS AND the IMPACT ON CHILDREN Anneke C. Hesseling Professor in Paediatrics and Child Health Director: Desmond Tutu TB center Stellenbosch University 11 September 11 th International
More informationSOUTH AFRICA S TB BURDEN - OVERVIEW
SOUTH AFRICA S TB BURDEN - OVERVIEW Dr Aaron Motsoaledi, MP: Chairperson of the Board, Stop TB Partnership Minister of Health, South Africa 31 January 2014, Cape Town South Africa s TB Burden Global TB
More informationVirtual Implementation Evaluation of Tuberculosis diagnostics in Tanzania Ivor Langley, Liverpool School of Tropical Medicine
Virtual Implementation Evaluation of Tuberculosis diagnostics in Tanzania Ivor Langley, Liverpool School of Tropical Medicine 3rd sector OR and developing countries 27th March 2013, London School of Economics
More informationPrinciple of Tuberculosis Control. CHIANG Chen-Yuan MD, MPH, DrPhilos
Principle of Tuberculosis Control CHIANG Chen-Yuan MD, MPH, DrPhilos Estimated global tuberculosis burden 2015 an estimated 10.4 million incident cases of TB (range, 8.7 million 12.2 million) 142 cases
More informationRevised National Tuberculosis Control Programme (RNTCP) Dr.Kishore Yadav J Assistant Professor
Revised National Tuberculosis Control Programme (RNTCP) Dr.Kishore Yadav J Assistant Professor Global scenario*: Burden of TB Incidence : 9.6 million (58% SEAR and Western Pacific) Deaths : 1.5 million
More informationTB EPIDEMIOLOGY: IMPACT ON CHILDREN. Anneke C. Hesseling Desmond Tutu TB Centre Department Paediatrics and Child Health Stellenbosch University
TB EPIDEMIOLOGY: IMPACT ON CHILDREN Anneke C. Hesseling Desmond Tutu TB Centre Department Paediatrics and Child Health Stellenbosch University Robert Koch 1843-1910 Discovered M. tuberculosis 1882 TB deaths
More informationXpert MTB/Rif What place for TB diagnosis in MSF projects? Francis Varaine, MSF Geneva, 29/11/10
Xpert MTB/Rif What place for TB diagnosis in MSF projects? Francis Varaine, MSF Geneva, 29/11/10 Introduction Excellent performances, rapid results, and easy to use Questions Where and how are we going
More informationThe epidemiology of tuberculosis
The epidemiology of tuberculosis Tuberculosis Workshop Shanghai, 12-22 May 28 Philippe Glaziou World Health Organization Outline Epidemiology refresher Estimates of tuberculosis disease burden Notifications
More information2010 global TB trends, goals How DOTS happens at country level - an exercise New strategies to address impediments Local challenges
Outline of what it will take Tuberculosis Elimination 25: Global and Local Challenges Anne Fanning, MD November 9, 211 21 global TB trends, goals How DOTS happens at country level - an exercise New strategies
More information511,000 (57% new cases) ~50,000 ~30,000
Latest global TB estimates - 2007 (Updated Mar 2009) All forms of TB Greatest number of cases in Asia; greatest rates per capita in Africa Multidrug-resistant TB (MDR-TB) Estimated number of cases 9.27
More informationMDR, XDR and Untreatable Tuberculosis and Laboratory Perspectives. Martie van der Walt TUBERCULOSIS EPIDEMIOLOGY & INTERVENTION RESEARCH UNIT
TUBERCULOSIS EPIDEMIOLOGY & INTERVENTION RESEARCH UNIT MDR, XDR and Untreatable Tuberculosis and Laboratory Perspectives Martie van der Walt IOM Meeting 15-17 January 2013 introduction 1 min 150 words
More informationDrug Resistant Tuberculosis Biology, Epidemiology and Control Dr. Christopher Dye
Director of Health Information World Health Organization Geneva 1 1. Why TB patients are treated with drugs 2 Natural history and control of TB Fast 5/1 Slow 5/1 Uninfected Latent Active 1 1 infection/case
More informationAssessing the programmatic management of drug-resistant TB
Assessing the programmatic management of drug-resistant TB a. Review the programmatic management of drug-resistant TB patients with the TB manager. i. What is the size of MDR-TB problem locally? How many
More informationGlobal epidemiology of drug-resistant tuberculosis. Factors contributing to the epidemic of MDR/XDR-TB. CHIANG Chen-Yuan MD, MPH, DrPhilos
Global epidemiology of drug-resistant tuberculosis Factors contributing to the epidemic of MDR/XDR-TB CHIANG Chen-Yuan MD, MPH, DrPhilos By the end of this presentation, participants would be able to describe
More informationTransmissibility, virulence and fitness of resistant strains of M. tuberculosis. CHIANG Chen-Yuan MD, MPH, DrPhilos
Transmissibility, virulence and fitness of resistant strains of M. tuberculosis CHIANG Chen-Yuan MD, MPH, DrPhilos Transmissibility, Virulence and Fitness of resistant strains of M. tuberculosis For infectious
More informationTB & HIV CO-INFECTION IN CHILDREN. Reené Naidoo Paediatric Infectious Diseases Broadreach Healthcare 19 April 2012
TB & HIV CO-INFECTION IN CHILDREN Reené Naidoo Paediatric Infectious Diseases Broadreach Healthcare 19 April 2012 Introduction TB & HIV are two of the leading causes of morbidity & mortality in children
More informationMultidrug-Resistant TB
Multidrug-Resistant TB Diagnosis Treatment Linking Diagnosis and Treatment Charles L. Daley, M.D. National Jewish Health University of Colorado Denver Disclosures Chair, Data Monitoring Committee for delamanid
More informationEpidemiology and diagnosis of MDR-TB in children H Simon Schaaf
Epidemiology and diagnosis of MDR-TB in children H Simon Schaaf Desmond Tutu TB Centre Department of Paediatrics and Child Health, Stellenbosch University, and Tygerberg Children s Hospital (TCH) Definitions
More informationTB Situation in Zambia/ TB Infection Control Program. Dr N Kapata Zambia National TB/Leprosy Control Programme Manager
/ TB Infection Control Program Dr N Kapata Zambia National TB/Leprosy Control Programme Manager Background Major public health problem Current (2014) notification rate is at 286/ 100,000 population. The
More informationInternational Standards for Tuberculosis Care Barbara J. Seaworth, MD August 22, 2007
TB Along the US/Mexico Border El Paso, Texas August 22-23, 2007 International Standards for Tuberculosis Care Barbara J. Seaworth, MD August 22, 2007 Barbara J Seaworth MD Medical Director Heartland National
More informationAddressing TB in a High HIV Prevalence Setting in Rural South Africa: the 3Is
Addressing TB in a High HIV Prevalence Setting in Rural South Africa: the 3Is Yale AIDS Program Section of Infectious Diseases Yale University School of Medicine Sheela Shenoi MD MPH September 20, 2012
More informationThe Rate of Sputum Smear-Positive Tuberculosis after Treatment Default in a High-Burden Setting: A Retrospective Cohort Study
The Rate of Sputum Smear-Positive Tuberculosis after Treatment Default in a High-Burden Setting: A Retrospective Cohort Study Florian M. Marx 1,2 *, Rory Dunbar 2, Donald A. Enarson 2,3, Nulda Beyers 2
More informationEpidemiology of drug-resistant tuberculosis among children and adolescents in South Africa
Epidemiology of drug-resistant tuberculosis among children and adolescents in South Africa 2005 2010 BK Moore 1, E Anyalechi 1, M van der Walt 2, S Smith 1, L Erasmus 3, J Lancaster 2, S Morris 1, N Ndjeka
More informationTitle: Meta-analysis of Individual patient Data (IPD) of Patients with INH (mono or poly-drug) Resistant Tuberculosis.
Title: Meta-analysis of Individual patient Data (IPD) of Patients with INH (mono or poly-drug) Resistant Tuberculosis. Principal Investigator: Dick Menzies, MD Evidence base for treatment of INH resistant
More informationCHAPTER 2. Literature review
CHAPTER 2 Literature review 2.1 INTRODUCTION A literature study is the focused attempt to become more familiar with what has been done in the area from documented information. The review of literature
More informationMODULE SIX. Global TB Institutions and Policy Framework. Treatment Action Group TB/HIV Advocacy Toolkit
MODULE SIX Global TB Institutions and Policy Framework Treatment Action Group TB/HIV Advocacy Toolkit 1 Topics to be Covered Global TB policy and coordinating structures The Stop TB Strategy TB/HIV collaborative
More informationGuidance on Matching Funds: Tuberculosis Finding the Missing People with TB
February 2017 Guidance on Matching Funds: Tuberculosis Finding the Missing People with TB 1. Background TB is the leading cause of death by infectious disease, killing 1.8 million people in 2015. Each
More informationRole of RNTCP in the management MDR-TB
Kamdar DJ, Shah NA, Patel DJ, Parmarr H. Role of RNTCP in the management of MDR-TB. IAIM, 2015; 2(7): 1-5. Original Research Article Role of RNTCP in the management of MDR-TB Deepali J Kamdar 1, Neha A
More informationModeling the diagnosis of HIVassociated
Modeling the diagnosis of HIVassociated TB: key research questions and data gaps Patrick GT Cudahy, MD Clinical Instructor Yale School of Medicine S L I D E 0 Diagnosis of TB in people living with HIV
More informationActive case finding. Care Pathways: Seek Find Follow
Active case finding Care Pathways: Seek Find Follow Overview The HIV/AIDS epidemic in Cape Winelands The NSP indicators Care pathways Historical perspective of case finding: TB Historical perspective of
More informationKristina Wallengren, PhD MPH
Kristina Wallengren, PhD MPH Head of Clinical Research K-RITH South Africa K-RITH S AIM: TO CONDUCT EXCELLENT BASIC SCIENCE IN TB AND HIV XDR TB outbreak in Tugela Ferry, KwaZulu-Natal, 2005 XDR TB PREVALENCE
More informationCMH Working Paper Series
CMH Working Paper Series Paper No. WG5 : 8 Title Interventions to reduce tuberculosis mortality and transmission in low and middle-income countries: effectiveness, cost-effectiveness, and constraints to
More informationPrinciples of Writing a Paper and getting it published. Anthony D Harries The Union, Paris, France MSF, Brussels, Belgium
Principles of Writing a Paper and getting it published Anthony D Harries The Union, Paris, France MSF, Brussels, Belgium BASIC STRUCTURE Title Page Abstract Introduction, aim and objectives Methods (includes
More informationLet s Talk TB A Series on Tuberculosis, A Disease That Affects Over 2 Million Indians Every Year
Let s Talk TB A Series on Tuberculosis, A Disease That Affects Over 2 Million Indians Every Year Lancelot M. Pinto, MD, MSc Author Madhukar Pai, MD, PhD co-author and Series Editor Lancelot Pinto is a
More informationGlobal, National, Regional
Epidemiology of TB: Global, National, Regional September 13, 211 Edward Zuroweste, MD Chief Medical Officer Migrant Clinicians Network Assistant Professor of Medicine Johns Hopkins School of Medicine Epidemiology
More informationGlobal, National, Regional
Epidemiology of TB: Global, National, Regional September 13, 211 Edward Zuroweste, MD Chief Medical Officer Migrant Clinicians Network Assistant Professor of Medicine Johns Hopkins School of Medicine Epidemiology
More informationPediatric TB research Barriers and progress
Pediatric TB research Barriers and progress Ben Marais www.sydney.edu.au/mbi www.tbcre.org.au Global Burden of TB - 2012 Estimated Incidence Estimated number of deaths All forms of TB 8.6 million (8.3
More informationTuberculosis and HIV: key issues in diagnosis and management
Tuberculosis and HIV: key issues in diagnosis and management Julian Elliott Infectious Diseases Unit, Alfred Hospital Centre for Population Health, Burnet Institute julian.elliott@alfred.org.au Outline
More informationThe need for new TB diagnostics in children and the way forward
The need for new TB diagnostics in children and the way forward Steve Graham Centre for International Child Health University of Melbourne Department of Paediatrics Royal Children s Hospital Melbourne
More informationTransmission of DS-TB and MDR-TB. C. Robert Horsburgh, Jr. Boston University School of Public Health
Transmission of DS-TB and MDR-TB C. Robert Horsburgh, Jr. Boston University School of Public Health Outline Epidemiologic factors in transmission Ability of the transmitter to transmit Susceptibility of
More informationOpen Access Article pissn eissn
Original article ASSESSMENT OF LONG-TERM OUTCOME AMONG NEW SMEAR POSITIVE PULMONARY TB PATIENTS TREATED WITH INTERMITTENT REGIMEN UNDER RNTCP A RETROSPECTIVE COHORT STUDY Paresh Dave 1, Kiran Rade 2, Bhavesh
More informationShort Course Treatment for MDR TB
Objectives Short Course Treatment for MDR TB Barbara J Seaworth M.D. Medical Director Heartland National TB Center Professor of Medicine, University of Texas Health Northeast Participants will utilize
More informationContact Follow-Up and Treatment of LTBI in Households of Infectious Cases in Pakistan
Contact Follow-Up and Treatment of LTBI in Households of Infectious Cases in Pakistan 17 th Annual Conference, The Union-North American Region, Vancouver, Canada. 28 February 2013 Farhana Amanullah Director
More informationPrevalence of tuberculosis (TB) infection and disease among adolescents western Kenya: preparation for future TB vaccine trials
Prevalence of tuberculosis (TB) infection and disease among adolescents western Kenya: preparation for future TB vaccine trials Videlis Nduba 1,2, Peter Onyango 1, Anja Van t Hoog 1,3, Anthony Hawkridge
More informationGuidelines for TB contact tracing in Pacific Island countries and territories
Guidelines for TB contact tracing in Pacific Island countries and territories Background Tuberculosis (TB) continues to be a public health issue of major significance around the world. The World Health
More informationTransmission of XDR TB
Transmission of XDR TB Neel Gandhi, MD Tugela Ferry Care & Research Collaboration (TF CARES) Albert Einstein College of Medicine November 5, 2008 TF CARES Tugela Ferry Care and Research Collaboration Background
More informationChildren as Sentinels for Transmission and Policy Response Mercedes Becerra, ScD
Children as Sentinels for Transmission and Policy Response Mercedes Becerra, ScD Associate Professor, Harvard Medical School, Boston, MA, USA TB Specialist, Partners In Health, Boston, MA, USA Overview
More informationTB in the Southern African mining sector and across the sub-region STOP TB Partnership Board Meeting By Dr Aaron Motsoaledi Minister of Health South
TB in the Southern African mining sector and across the sub-region STOP TB Partnership Board Meeting By Dr Aaron Motsoaledi Minister of Health South Africa 1 Framing the Public Health Challenge Africa
More informationTB/HIV prevention. Implementation science and TB prevention
TB/HIV prevention Implementation science and TB prevention Success is moving from one failure to another with no loss of enthusiasm. ~ Sir Winston Churchill NSP and PFIP Impact indicators NSP Indicator
More information4/25/2012. The information on patterns of infection and disease can assist in: Assessing current and evolving trends in TB
Sindy M. Paul, MD, MPH, FACPM May 1, 2012 The information on patterns of infection and disease can assist in: Assessing current and evolving trends in TB morbidity, including resistance Identifying people
More informationDrug-resistant Tuberculosis
page 1/15 Scientific Facts on Drug-resistant Tuberculosis Source document: WHO (2008) Summary & Details: GreenFacts Level 2 - Details on Drug-resistant Tuberculosis 1. What is tuberculosis and why is it
More informationLatest developments in WHO estimates of TB disease burden
Latest developments in WHO estimates of TB disease burden WHO Global Task Force on TB Impact Measurement meeting Glion, 1-4 May 2018 Philippe Glaziou, Katherine Floyd 1 Contents Introduction 3 1. Recommendations
More informationUpcoming TB Alliance Studies. CPRT DST Review September, 2014
Upcoming TB Alliance Studies CPRT DST Review September, 2014 STAND PaMZ Ph 3 STAND: Phase 3 Trial of the Pa-M-Z Regimen Participants with newly diagnosed smear positive DS- and MDR-TB DS Pa(100mg)-M-Z
More informationTuberculosis in children: gaps and opportunities
Tuberculosis in children: gaps and opportunities Mark Nicol Division of Medical Microbiology and Institute for Infectious Diseases and Molecular Medicine, University of Cape Town and National Health Laboratory
More informationIntensified TB case finding among PLHIV and vulnerable population Identifying contacts Gunta Kirvelaite
Intensified TB case finding among PLHIV and vulnerable population Identifying contacts Gunta Kirvelaite Riga East Clinical hospital, Centre for tuberculosis and lung diseases. Head of outpatient department.
More informationPredictors of drug sensitive tuberculosis treatment outcomes among hospitalised
Predictors of drug sensitive tuberculosis treatment outcomes among hospitalised patients in South Africa: a multinomial logit model Abiola O. Olaleye 1,* and Andy K. Beke 1 1 School of Health Systems and
More information: uptake and impact of Xpert MTB/RIF
Photo: Riccardo Venturi 21-215: uptake and impact of Xpert MTB/RIF Wayne van Gemert WHO Global TB Programme, Geneva Joint Partners Forum for Strengthening and Aligning TB Diagnosis and Treatment 27-3 April
More informationControlling TB in the era of HIV
Controlling TB in the era of HIV Christy Hanson, PhD, MPH TB Research Advisor Amy Bloom, MD TB/HIV Advisor TB Incidence rates highest in Africa Estimated new TB cases (all forms) per 100 000 population
More informationEvolution of XDR-TB. A. Willem Sturm Interim Director K-RITH Nelson R Mandela School of Medicine University of KwaZulu-Natal
Evolution of XDR-TB in KwaZulu-Natal A. Willem Sturm Interim Director K-RITH Nelson R Mandela School of Medicine University of KwaZulu-Natal Drug resistance among culture positive TB cases by South African
More informationDrug-resistant Tuberculosis
page 1/6 Scientific Facts on Drug-resistant Tuberculosis Source document: WHO (2008) Summary & Details: GreenFacts Context - Tuberculosis (TB) is an infectious disease that affects a growing number of
More informationTB IN EMERGENCIES. Disease Control in Humanitarian Emergencies (DCE)
TB IN EMERGENCIES Department of Epidemic and Pandemic Alert and Response (EPR) Health Security and Environment Cluster (HSE) (Acknowledgements WHO Stop TB Programme WHO/STB) 1 Why TB? >33% of the global
More informationGlobal Perspective on Transmission: Value in Genotype Mapping of Disease Transmission Dynamics
Global Perspective on Transmission: Value in Genotype Mapping of Disease Transmission Dynamics Neel R. Gandhi, MD Emory Rollins School of Public Health January 17, 2013 Medical Research Council BMJ 1948
More informationXpert MTB/RIF assay validation experience --- impact and plan in China
Xpert MTB/RIF assay validation experience --- impact and plan in China Dr. Zhao Yanlin Chinese Center for Disease Control & Prevention Dr. Richard O Brien FIND April. 16, 2013 Progress Contribution for
More informationDiagnosis of drug resistant TB
Diagnosis of drug resistant TB Megan Murray, MD, ScD Harvard School of Public Health Brigham and Women s Hospital Harvard Medical School Broad Institute Global burden of TB 9 million new cases year 2 million
More informationClinical and Public Health Impact of Nucleic Acid Amplification Tests (NAATs) for Tuberculosis
Clinical and Public Health Impact of Nucleic Acid Amplification Tests (NAATs) for Tuberculosis Amit S. Chitnis, MD, MPH; Pennan M. Barry, MD, MPH; Jennifer M. Flood, MD, MPH. California Tuberculosis Controllers
More informationRevised National Tuberculosis Control Programme
Revised National Tuberculosis Control Programme 1 OUTLINE OF PRESENTATION Introduction Burden Of The Disease Evolution Of RNTCP Goals And Objectives Of RNTCP DOTS Stop TB Strategy Organization RNTCP Endorsed
More informationDefinitions and reporting framework for tuberculosis 2013 revision. Dennis Falzon Global Forum of Xpert MTB/RIF Implementers Annecy 17 April 2013
Definitions and reporting framework for tuberculosis 2013 revision Dennis Falzon Global Forum of Xpert MTB/RIF Implementers Annecy 17 April 2013 2-year revision process WHO/HTM/TB/2013.2 2 www.who.int/iris/bitstream/10665/79199/1/9789241505345_eng.pdf
More informationInvesting for Impact
Global Fund Strategic Framework: Investing for Impact M&E: Capturing data to improve services Workshop to Scale Up the Implementation of Collaborative TB/HIV Activities in Africa 10-11 April, 2013; Maputo,
More informationTB Disease Prevalence Survey - Overview and Introduction of the TF
TB Disease Prevalence Survey - Overview and Introduction of the TF Ikushi Onozaki MD, MPH Team Leader, TB Prevalence Survey WHO Global Task Force on TB Impact Measurement Stop TB Department, WHO onozakii@who.int
More informationElizabeth A. Talbot MD Assoc Professor, ID and Int l Health Deputy State Epidemiologist, NH GEISELMED.DARTMOUTH.EDU GEISELMED.DARTMOUTH.
The image part with relationship ID rid2 was not found in the file. MDR TB Management Review of the Evolution (or Revolution?) Elizabeth A. Talbot MD Assoc Professor, ID and Int l Health Deputy State Epidemiologist,
More informationHIV Clinicians Society Conference TB/HIV Treatment Cascade
HIV Clinicians Society Conference-2012 TB/HIV Treatment Cascade Dr Judith Mwansa-Kambafwile Wits Reproductive Health & HIV Institute University of Witwatersrand TB/HIV Treatment Cascade Overview TB stats
More informationQian Gao Fudan University
Qian Gao Fudan University Outline Background & Objectives Genotyping methods Establish the epidemiological field sites Preliminary results of Molecular epidemiology of TB in China Molecular epidemiology
More informationState of the State in TB Control
State of the State in TB Control Jason Stout, MD, MHS Wake County TB Medical Consultant NC TB Medical Director Division of Infectious Diseases, Duke University Medical Center Disclosures-Funding NIH (grant)
More informationPrinciples and Structure of a Research Protocol. Anthony D Harries The Union, Paris, France MSF, Brussels, Belgium
Principles and Structure of a Research Protocol Anthony D Harries The Union, Paris, France MSF, Brussels, Belgium BASIC STRUCTURE Background and rationale to study Aim and objectives (the research question)
More informationDiagnosis of tuberculosis in children
Diagnosis of tuberculosis in children H Simon Schaaf Desmond Tutu TB Centre Department of Paediatrics and Child Health, Stellenbosch University, and Tygerberg Children s Hospital (TCH) Estimated TB incidence
More informationImpact of HIV on the TB Epidemic in Africa
Impact of HIV on the TB Epidemic in Africa Anthony David Harries Senior Advisor International Union against TB and Lung Disease The captain of all these men of death 1 Robert Koch 1882: Described the tubercle
More informationINH Preventive Therapy in. Mark F Cotton KID-CRU & Division of Pediatric Infectious Diseases, TygerbergChildren s Hospital & Stellenbosch University
INH Preventive Therapy in Children Mark F Cotton KID-CRU & Division of Pediatric Infectious Diseases, TygerbergChildren s Hospital & Stellenbosch University Prophylactic effect of INH on primary TB in
More informationTB Disease Prevalence Survey - Progress Report
TB Disease Prevalence Survey - Progress Report 30 Oct 2011, Lille Ikushi Onozaki MD, MPH Team Leader, TB Prevalence Survey WHO Global Task Force on TB Impact Measurement Stop TB Department, WHO onozakii@who.int
More informationTsira Chakhaia 1 *, Matthew J. Magee 2,3, Russell R. Kempker 4, Medea Gegia 1, Leila Goginashvili 5, Ucha Nanava 5, Henry M. Blumberg 3,4.
High Utility of Contact Investigation for Latent and Active Tuberculosis Case Detection among the Contacts: A Retrospective Cohort Study in Tbilisi, Georgia, 2010 2011 Tsira Chakhaia 1 *, Matthew J. Magee
More informationSTREAM Trial Update. I.D. Rusen, The Union CPTR Meeting April 5, 2016 Washington, DC
STREAM Trial Update I.D. Rusen, The Union CPTR Meeting April 5, 2016 Washington, DC Financial Disclosure The Union receives funding from various sources to implement the STREAM Trial: Stage 1 USAID (TREAT
More information11/3/2009 SECOND EDITION Madhukar Pai McGill University. ISTC Training Modules Introduction
SECOND EDITION 2009 Madhukar Pai McGill University Introduction 1 Purpose of ISTC ISTC Version 2: Key Points 21 Standards Differ from existing guidelines: standards present what should be done, whereas,
More informationKenya Perspectives. Post-2015 Development Agenda. Tuberculosis
Kenya Perspectives Post-2015 Development Agenda Tuberculosis SPEAKERS Anna Vassall Anna Vassall is Senior Lecturer in Health Economics at the London School of Hygiene and Tropical Medicine. She is a health
More informationThe Impact of Effective Treatment on TB Transmission FAST: A re-focused, intensified, administrative approach to institutional TB transmission control
The Impact of Effective Treatment on Transmission FAST: A re-focused, intensified, administrative approach to institutional transmission control Edward A. Nardell, MD Professor of Medicine Brigham & Women
More informationContact Investigation
Tuberculosis Ann Raftery, RN, PHN, MSc GHS Learning Objectives Upon completion of this session, participants will be able to: Describe the criteria used and method for determining the infectious period
More informationAnnex A: Impact, Outcome and Coverage Indicators (including Glossary of Terms)
IMPACT INDICATORS (INDICATORS PER GOAL) HIV/AIDS TUBERCULOSIS MALARIA Reduced HIV prevalence among sexually active population Reduced HIV prevalence in specific groups (sex workers, clients of sex workers,
More informationCurrent status of implementation and monitoring and evaluation of collaborative TB/HIV activities. Avinash Kanchar
Current status of implementation and monitoring and evaluation of collaborative TB/HIV activities Avinash Kanchar Outline WHO guide to M&E of collaborative TB/HIV activities: 2015 Reporting status on Global
More informationStrengthening and aligning diagnosis and treatment of drug-resistant TB in Russian Federation
LOGO Strengthening and aligning diagnosis and treatment of drug-resistant TB in Russian Federation Irina A.Vasilyeva Chief TB Specialist of the Russian Ministry of Health Central TB Research Institute,
More informationTB Control in Finland - the role of THL
TB Control in Finland - the role of THL Hanna Soini THL, Department of Health Security 1 TB in Finland 1950-2014 12000 10000 8000 6000 TB ulkomaalaiset TB yhteensä 4000 2000 0 1950 1955 1960 1965 1970
More informationOsaka City is the third largest city (population
Surveillance Report Strengthened tuberculosis control programme and trend of multidrug resistant tuberculosis rate in Osaka City, Japan Akira Shimouchi, a Akihiro Ohkado, a Kenji Matsumoto, b Jun Komukai,
More informationClinical Practice Guideline
ITBS LTBI ITBS Management 1 of 6 ITBS Contact ITBS Oversight ITBS Disease Professional Advisory 1.0 PURPOSE: 1.1 Provide clinical practice and operational guidance to Public Health Nurses to ensure consistency
More informationIntensified TB Case Finding using a TB screening tool integrated into an HIV clinical record: Experiences from the Eastern Cape Province
Intensified TB Case Finding using a TB screening tool integrated into an HIV clinical record: Experiences from the Eastern Cape Province Dr. Sabine Verkuijl Technical Advisor: TB/HIV Integration, ICAP-SA
More informationTurning Off the Spigot Reducing Nosocomial Drug Resistant TB. Edward A. Nardell, MD Harvard Medical School/PIH Brigham & Women s Hospital
Turning Off the Spigot Reducing Nosocomial Drug Resistant Transmission Edward A. Nardell, MD Harvard Medical School/PIH Brigham & Women s Hospital is an airborne infection Every case of MDR/XDR prevented
More informationIsoniazid Prevention Therapy for HIV Positive Patients
Isoniazid Prevention Therapy for HIV Positive Patients Increasing Tuberculosis Prevention for HIV-Patients in Ethiopia QuickTime and a decompressor are needed to see this picture. Ashok Reddy, MD University
More informationTreatment of Extensively Drug Resistant Tuberculosis Among Patients with HIV Infection in South Africa
Treatment of Extensively Drug Resistant Tuberculosis Among Patients with HIV Infection in South Africa Max O Donnell, Nesri Padayatchi, Iqubal Master, Garth Osburn, Robert Horsburgh Outline 1. XDR-TB in
More informationTuberculosis among public sector healthcare workers in ethekwini District, KwaZulu-Natal
ORIGINAL RESEARCH Tuberculosis among public sector healthcare workers in ethekwini District, KwaZulu-Natal S Mahomed 1, DR Khilawan 2, S Knight 2 1 School of Laboratory Medicine and Medical Science, College
More informationLet s Talk TB. A Series on Tuberculosis, A Disease That Affects Over 2 Million Indians Every Year
A Series on Tuberculosis, A Disease That Affects Over 2 Million Indians Every Year Lancelot M. Pinto, MD, MSc Author Madhukar Pai, MD, PhD co-author and Series Editor Abstract Nearly 50% of patients with
More informationEthiopia. Targeted Tuberculosis Case Finding Interventions in Six Mining Shafts in Remote Districts of Oromia Region in Ethiopia PROJECT CONTEXT
Technical BRIEF Photo Credit: Challenge TB Targeted Tuberculosis Case Finding Interventions in Six Mining Shafts in Remote Districts of Oromia Region in Ethiopia PROJECT CONTEXT Ethiopia is the second-most
More informationCOMMUNITY-BASED TBHIV CASE-FINDING KENYAN EXPERIENCE
COMMUNITY-BASED TBHIV CASE-FINDING KENYAN EXPERIENCE Exposing a hidden epidemic Kenya TB/HIV TEAM Introduction Population: 40 million 15 th among the 22 high TB burden countries 2012: TB case notification
More informationSURVEY FINDINGS April 28, 2017
SURVEY FINDINGS April 28, 2017 Brenda Mungai Centre for Health Solutions-Kenya, TB ARC Outline Background Survey Rationale Methods Key Findings Conclusions Call to Action KENYA TUBERCULOSIS PREVALENCE
More information