Review on Tumour Doubling Time (DT) To review the studies that measuring the actual tumour doubling time for human cancers.
|
|
- Colleen Lyons
- 5 years ago
- Views:
Transcription
1 Review on Tumour Doubling Time (DT) Objective To review the studies that measuring the actual tumour doubling time for human cancers. Methods We searched the Medline database from January 1966 to January 2006 with the key words or Medical Subject Headings (MeSH) neoplasms, doubling time, growth rate, volume increase or Td. All the studies were limited to human cancers and English literature. We also performed a manual search of reference cited in the original articles and the reviews. Results We identified 128 relevant studies in the literature. Their characteristics are described in Table 1. Figure 1 shows that there are systematic differences in DT among different types of cancer (Kruskal-Wallis one way analysis of variance: Chi-square=172.5, p< Two-sample Wilcoxon test is presented in Table 2) as well as wide dispersion of DTs within individual types of cancer. Figure 2 illustrates the distributions of DTs of breast cancer, lung cancer and head and neck cancer. The distribution of breast and head and neck cancer are approximately lognormal. For head and neck cancer, the distribution of DT is even broader. Figure 3 shows that in the selected sites where the necessary information was available, recurrent and metastatic cancers generally grow more rapidly than primary cancers. Conclusion Overall, the tumour doubling time is highly heterogeneous within as well as among different types of cancer. This finding precludes the development of disease-specific benchmarks for waiting time.
2 Table 1. Characteristics of studies describing the tumour doubling time Category No. of studies(%) Sample size N=128 Primary site Breast 11(8.59%) 1043 Prostate (PSA DT) 21(16.4%) 3335 Head neck 23(17.9%) 637 Lung 22(17.2%) 1041 Hepatic 12(9.4%) 312 Colorectal 9(7.0%) 234 Pancreatic 3(2.34%) 85 Renal 2(1.56%) 73 Gastric 3(2.34%) 33 Sarcoma 4(3.13%) 446 Others 18(14.06%) 832 Year (1.56%) (8.59%) (7.81%) (15.6%) (8.59%) (16.4%) (18.75%) (22.65%) 3178 Sample size (13.3%) (59.3%) (10.9%) 1061 >100 21(16.4%) 4714 Measure methods Tumor marker 26(20.3%) 3484 Plain X-ray 45(35.1%) 2737 CT scan or MRI 52(40.6%) 1241 Clinical or Pathological 5(3.9%) 331 Report 3 - Appendix 2
3 Table 2. Two Sample Wilcoxon Test of Distribution of Tumour Doubling Time site1 site2 Two-sample Wilcoxon Statistic P-value, Wilcoxon Test (Twosided) Report 3 - Appendix 2 Significance breast gastric breast head/neck breast hepatic breast lung breast pancreas gastric colorectal head/neck colorectal hepatic colorectal lung colorectal pancreas colorectal gastric head/neck gastric pancreas gastric hepatic gastric lung head/neck hepatic head/neck lung head/neck pancreas lung hepatic pancreas hepatic lung pancreas
4 Prostate Gastric Breast Colorectal Lung Hepatic Head/Neck Pancreas Fig.1. Tumour Doubling Time by Primary Cancer Site Figure 1 describes all the studies we identified in literature about the tumour doubling time. If the original studies provided the tumour doubling time of each case, they were combined and plotted (Black dots). The red strip is the median tumour doubling time of all the cases in each group; if the median and number of cases were provided, they were indicated by bubble, and the size of bubble was corresponding to the number of cases (Blue bubble); if the mean was provided, they were also plotted by using bubbles (Green bubble). The raw information about DT for prostate cancer is scarce so that the median DT was not plotted.
5 Fig.2. Distribution of Tumour Doubling Time Figure 2 illustrates the distribution of tumour doubling time on a log scale. The red curve is the normal density curve.
6 38 prostate Fig.3 Tumour Doubling Time for each cancer site 24 colorectal 9 8
7 8 1 headneck 8 30 breast 14
8 18 lung hepatic 6
9 6 pancreas
PATHWAY FOR INVESTIGATION OF ADULTS PRESENTING WITH ASCITES. U/S Abdo/pelvis shows ascites without obvious evidence of 1 liver disease
PATHWAY FOR INVESTIGATION OF ADULTS PRESENTING WITH ASCITES U/S Abdo/pelvis shows ascites without obvious evidence of 1 liver disease Refer back to original requester with this paperwork and review previous
More informationLong-term survival rate of stage I-III small cell lung cancer patients in the SEER database - application of the lognormal model
Long-term survival rate of stage I-III small cell lung cancer patients in the SEER database - application of the lognormal model Patricia Tai, MD, (Acting Director of Radiation Oncology), Edward Yu, MD,
More informationPET IMAGING (POSITRON EMISSION TOMOGRAPY) FACT SHEET
Positron Emission Tomography (PET) When calling Anthem (1-800-533-1120) or using the Point of Care authorization system for a Health Service Review, the following clinical information may be needed to
More informationSupplementary Online Content
Supplementary Online Content Chacón MR, Enrico DH, Burton J, Waisberg FD, Videla VM. Incidence of placebo adverse events in randomized clinical trials of targeted and immunotherapy cancer drugs in the
More informationTitle: What is the role of pre-operative PET/PET-CT in the management of patients with
Title: What is the role of pre-operative PET/PET-CT in the management of patients with potentially resectable colorectal cancer liver metastasis? Pablo E. Serrano, Julian F. Daza, Natalie M. Solis June
More informationClinical indications for positron emission tomography
Clinical indications for positron emission tomography Oncology applications Brain and spinal cord Parotid Suspected tumour recurrence when anatomical imaging is difficult or equivocal and management will
More informationIndex. Surg Oncol Clin N Am 16 (2007) Note: Page numbers of article titles are in boldface type.
Surg Oncol Clin N Am 16 (2007) 465 469 Index Note: Page numbers of article titles are in boldface type. A Adjuvant therapy, preoperative for gastric cancer, staging and, 339 B Breast cancer, metabolic
More information2. The effectiveness of combined androgen blockade versus monotherapy.
Relative effectiveness and cost-effectiveness of methods of androgen suppression in the treatment of advanced prostate cancer Blue Cross and Blue Shield Association, Aronson N, Seidenfeld J Authors' objectives
More informationpulmonary metastasis 80EE4727C6037E7F69A9981B7E55A238 Pulmonary Metastasis 1 / 6
Pulmonary Metastasis 1 / 6 2 / 6 3 / 6 Pulmonary Metastasis Metastatic tumors in the lungs are cancers that developed at other places in the body (or other parts of the lungs). They then spread through
More informationTable of Contents. Plots. Essential Statistics for Nursing Research 1/12/2017
Essential Statistics for Nursing Research Kristen Carlin, MPH Seattle Nursing Research Workshop January 30, 2017 Table of Contents Plots Descriptive statistics Sample size/power Correlations Hypothesis
More informationOverview of All SEER-Medicare Publications
Overview of All SEER-Medicare Publications Outcomes Insights, Inc. Mark D. Danese, MHS, PhD Claire Cangialose February 22, 2017 Overview Information was extracted from the National Cancer Institute (NCI)
More informationSarcoma. National Follow-up Guidelines
North, South East and West of Scotland Cancer Networks Sarcoma National Managed Clinical Network Sarcoma National Follow-up Guidelines Prepared by Dr Ioanna Nixon, Dr Lucy Wall and Lindsay Campbell Approved
More informationTumour Markers. For these reasons, only a handful of tumour markers are commonly used by most doctors.
Tumour Markers What are Tumour Markers? Tumour markers are substances that can be found in the body when cancer is present. They are usually found in the blood or urine. They can be products of cancer
More informationDEPARTMENT OF ONCOLOGY ELECTIVE
DEPARTMENT OF ONCOLOGY ELECTIVE 2015-2016 www.uwo.ca/oncology Oncology Elective Program Administrator: Ms. Kimberly Trudgeon Room A4-901C (Admin) LHSC London Regional Cancer Centre (Victoria Campus) Phone:
More informationA research briefing paper by Macmillan Cancer Support
A research briefing paper by Macmillan Cancer Support Introduction Key findings 3 People with cancer are surviving longer 4 Median survival time has seen dramatic improvement for some cancers 5 Median
More informationAuditorium. Title: Welcome and Introduction by the Chairs Moderation: M. Pless, A. Cervantes ; Winterthur, CH, Valencia, ES
08-04-2017 12:45-13:00 Type: Educational session Title: Welcome and Introduction by the Chairs 1 2 1 2 Moderation: M. Pless, A. Cervantes ; Winterthur, CH, Valencia, ES 12:45-13:00 Welcome 13:00-13:15
More informationCancer Prevention & Control in Adolescent & Young Adult Survivors
+ Cancer Prevention & Control in Adolescent & Young Adult Survivors NCPF Workshop July 15-16, 2013 Patricia A. Ganz, MD UCLA Schools of Medicine & Public Health Jonsson Comprehensive Cancer Center + Overview
More informationPhase-specific Costs of Cancer Care in Ontario
Phase-specific Costs of Cancer Care in Ontario Canadian Association of Health Services and Policy Research Conference Session: D5 Cancer Care Wednesday May 29 2013 Claire de Oliveira, M.A. PhD Background
More informationAN EMPIRICAL EVALUATION OF PERIOD SURVIVAL ANALYSIS USING DATA FROM THE CANADIAN CANCER REGISTRY. Larry F. Ellison MSc, Statistics Canada
AN EMPIRICAL EVALUATION OF PERIOD SURVIVAL ANALYSIS USING DATA FROM THE CANADIAN CANCER REGISTRY Larry F. Ellison MSc, Statistics Canada Introduction Long-term survival rates are important outcome measures
More informationCancer of Unknown Primary Service
Cancer of Unknown Primary Service Dr Maurice Fernando Consultant In Specialist Palliative Care and CUP lead Doncaster and Bassetlaw Hospitals NHS FT Wakefield meeting -14-07-2016 CUP service CUP MDT
More informationperformed to help sway the clinician in what the appropriate diagnosis is, which can substantially alter the treatment of management.
Hello, I am Maura Polansky at the University of Texas MD Anderson Cancer Center. I am a Physician Assistant in the Department of Gastrointestinal Medical Oncology and the Program Director for Physician
More informationSamuel M. Lesko, MD, MPH Director of Research/Medical Director
Cancer in Northeastern Pennsylvania: Incidence, Mortality and Survival for Common Cancers Samuel M. Lesko, MD, MPH Director of Research/Medical Director May 11 334 Jefferson Avenue, Scranton, PA 1851-57-941-7984
More informationOncolytic Viruses: Reovirus
T S X : O N C N A S D A Q : O N C Y International Society for Biological Therapy of Cancer 2008 Oncology Biologics Development Primer Oncolytic Viruses: Reovirus REOLYSIN - mode of action REOLYSIN contains
More informationEvidence Based Medicine
Course Goals Goals 1. Understand basic concepts of evidence based medicine (EBM) and how EBM facilitates optimal patient care. 2. Develop a basic understanding of how clinical research studies are designed
More informationPhase-specific Net Costs of Cancer Care in Ontario. Claire de Oliveira, M.A. PhD
Phase-specific Net Costs of Cancer Care in Ontario Claire de Oliveira, M.A. PhD Background Cancer: leading cause of death in Canada with costly implications for government and patients Cost estimates of
More informationSupplementary Online Content
Supplementary Online Content Henson KE, Brock R, Charnock J, Wickramasinghe B, Will O, Pitman A. Risk of suicide after cancer diagnosis in England. JAMA Psychiatry. Published online November 21, 2018.
More informationCausation Issues. Delay in Diagnosis of Cancer Cases. Prof Pat Price Imperial College London
Causation Issues Delay in Diagnosis of Cancer Cases Prof Pat Price Imperial College London office@patprice.co.uk www.patprice.co.uk Faculty of Advocates Annual conference 18 th June 2018 EVIDENCE BASED
More informationChina Medical Technologies, Inc.
China Medical Technologies, Inc. China Medical Technologies, Inc. (CMT) is a high-tech enterprise, trading on Nasdaq with the ticker CMED. We currently conduct our operations principally through our wholly-owned
More informationDiagnosis and management of retroperitoneal sarcoma
SON Update 2017 Diagnosis and management of retroperitoneal sarcoma Andrea J MacNeill, MD MSc FRCSC Surgical Oncologist, BC Cancer Agency Vancouver 2 Histologic Subtypes of STS 3 RP Subtypes (n=684) Extremity
More informationSTATISTICS IN CLINICAL AND TRANSLATIONAL RESEARCH
09/07/11 1 Overview and Descriptive Statistics a. Application of statistics in biomedical research b. Type of data c. Graphic representation of data d. Summary statistics: central tendency and dispersion
More informationCancers of unknown primary : Knowing the unknown. Prof. Ahmed Hossain Professor of Medicine SSMC
Cancers of unknown primary : Knowing the unknown Prof. Ahmed Hossain Professor of Medicine SSMC Definition Cancers of unknown primary site (CUPs) Represent a heterogeneous group of metastatic tumours,
More informationCase 18. M75. Excision of mass on scalp. Clinically SCC. The best diagnosis is:
Case 18 M75. Excision of mass on scalp. Clinically SCC. The best diagnosis is: A. Pilomatrical carcinoma B. Adnexal carcinoma NOS C. Metastatic squamous cell carcinoma D.Primary squamous cell carcinoma
More informationPhysician Follow-Up and Guideline Adherence in Post- Treatment Surveillance of Colorectal Cancer
Physician Follow-Up and Guideline Adherence in Post- Treatment Surveillance of Colorectal Cancer Gabriela M. Vargas, MD Kristin M. Sheffield, PhD, Abhishek Parmar, MD, Yimei Han, MS, Kimberly M. Brown,
More informationImproving Cancer Pathways. Mel Warwick Macmillan Cancer Manager / Lead Nurse Aintree University Hospital NHS Foundation Trust
Improving Cancer Pathways Mel Warwick Macmillan Cancer Manager / Lead Nurse Aintree University Hospital NHS Foundation Trust Background Poor / inconsistent 62 day performance, across a number of specialities
More informationNuclear Medicine in Australia. Shaun Jenkinson
Nuclear Medicine in Australia Shaun Jenkinson Landmark Infrastructure for Australian Science OPAL Research Reactor Australian Synchrotron Camperdown Cyclotron Bragg Institute Centre for Accelerator Science
More informationNational Cancer Drugs Fund List - Approved
National Cancer Drugs Fund List - Approved DRUG Abiraterone Aflibercet Albumin Bound Paclitaxel Axitinib CDF INDICATION (EXCLUDING APPROVED CRITERIA ) Metastatic Prostate Cancer Metastatic Colorectal Cancer
More informationLearning Objectives 9/9/2013. Hypothesis Testing. Conflicts of Interest. Descriptive statistics: Numerical methods Measures of Central Tendency
Conflicts of Interest I have no conflict of interest to disclose Biostatistics Kevin M. Sowinski, Pharm.D., FCCP Last-Chance Ambulatory Care Webinar Thursday, September 5, 2013 Learning Objectives For
More informationPresentation with lymphadenopathy
Presentation with lymphadenopathy Theo M. de Reijke MD PhD FEBU Department of Urology Academic Medical Center Amsterdam Rationale for RRP in N+ disease Prevention local problems Better survival in limited
More information9/4/2013. Decision Errors. Hypothesis Testing. Conflicts of Interest. Descriptive statistics: Numerical methods Measures of Central Tendency
Conflicts of Interest I have no conflict of interest to disclose Biostatistics Kevin M. Sowinski, Pharm.D., FCCP Pharmacotherapy Webinar Review Course Tuesday, September 3, 2013 Descriptive statistics:
More informationSUPPLEMENTARY INFORMATION
SUPPLEMENTARY NFORMATON n format provided by Melero et al. (AUGUST 2015) Supplementary nformation S3 Combinations including two or more immunotherapy agents based on PD-1/PD-L1 blockade. (Source: https://clinicaltrials.gov/
More informationPresentation with lymphadenopathy
Presentation with lymphadenopathy Theo M. de Reijke MD PhD FEBU Department of Urology Academic Medical Center Amsterdam Rationale for RRP in N+ disease Prevention local problems Better survival in limited
More informationSupplementary Figure 1. Metabolic landscape of cancer discovery pipeline. RNAseq raw counts data of cancer and healthy tissue samples were downloaded
Supplementary Figure 1. Metabolic landscape of cancer discovery pipeline. RNAseq raw counts data of cancer and healthy tissue samples were downloaded from TCGA and differentially expressed metabolic genes
More informationMolecular Imaging in the Development of Cancer Therapeutics. Johannes Czernin
Molecular Imaging in the Development of Cancer Therapeutics Johannes Czernin Ahmanson Biological Imaging Division University of California Los Angeles Cancer Statistics Cancer Type 5-year Survival Rate
More informationOverview of 2009 Hong Kong Cancer Statistics
Overview of 2009 Hong Kong Cancer Statistics Cancer Registration in Hong Kong The Hong Kong Cancer Registry has since 1963 been providing population-based cancer data for epidemiological research and healthcare
More informationMedical Policy An independent licensee of the Blue Cross Blue Shield Association
PET Scanning: Oncologic Applications Page 1 of 88 Medical Policy An independent licensee of the Blue Cross Blue Shield Association Title: Positron Emission Tomography (PET) Scanning: Oncologic Applications
More informationClinicalTrials.gov "Basic Results" Data Element Definitions (DRAFT)
ClinicalTrials.gov "Basic Results" Data Element Definitions (DRAFT) January 9, 2009 * Required by ClinicalTrials.gov [*] Conditionally required by ClinicalTrials.gov (FDAAA) May be required to comply with
More informationIdentifying and counting people living with treatable but not curable cancer
Identifying and counting people living with treatable but not curable cancer Rachel White Joanna Pethick, Archie Macnair, Gregory Fallica, Jennifer Than and Jane Maher September 2018 Who are the people
More informationPLACE LABEL HERE. Radiation Therapy Oncology Group Phase II - SBRT - Medically Inoperable I /II NSCLC Follow-up Form. RTOG Study No.
Radiation Therapy Oncology Group Phase II - SBRT - Medically Inoperable I /II NSCLC Follow-up Form RTOG Study No. 0813 Case # Name RTOG Patient ID INSTRUCTIONS: Submit this form at the appropriate followup
More informationSingle-strand DNA library preparation improves sequencing of formalin-fixed and paraffin-embedded (FFPE) cancer DNA
www.impactjournals.com/oncotarget/ Oncotarget, Supplementary Materials 2016 Single-strand DNA library preparation improves sequencing of formalin-fixed and paraffin-embedded (FFPE) DNA Supplementary Materials
More informationGenetic Predisposition to Cancer
Genetic Predisposition to Cancer Elena Castro, MD, PhD Prostate Cancer and GU tumours Unit Spanish National Cancer Research Centre Madrid, Spain Abstract 750O: Early detection of hereditary renal cell
More informationHepatobiliary and Pancreatic Malignancies
Hepatobiliary and Pancreatic Malignancies Gareth Eeson MD MSc FRCSC Surgical Oncologist and General Surgeon Kelowna General Hospital Interior Health Consultant, Surgical Oncology BC Cancer Agency Centre
More informationThe Relationship Between Surgical Volume and Patient Outcomes in Urologic Malignancies
The Relationship Between Surgical Volume and Patient Outcomes in Urologic Malignancies Geoffrey Gotto PGY-5 UBC Department of Urologic Sciences October 8 th, 2008 Objective To review the literature on
More informationList of Available TMAs in the PRN
TMA RPCI_BrainCa01 RPCI_BrCa03 RPCI_BrCa04 RPCI_BrCa05 RPCI_BrCa0 RPCI_BrCa07 RPCI_BrCa08 RPCI_BrCa15 RPCI_BrCa1 RPCI_BrCa17 RPCI_BrCa18 RPCI_BrCa19 RPCI_BrCa20 RPCI_BrCa21 RPCI_BrCa24 RPCI_BrCa25 RPCI_BrCa2
More informationInformation Services Division NHS National Services Scotland
Cancer in Scotland October 2012 First published in June 2004, revised with each National Statistics publication Next due for revision April 2013 Information Services Division NHS National Services Scotland
More informationUpper GI Malignancies Imaging Guidelines for the Management of Gastric, Oesophageal & Pancreatic Cancers 2012
Upper GI Malignancies Imaging Guidelines for the Management of Gastric, Oesophageal & Pancreatic Cancers 2012 Version Control This is a controlled document please destroy all previous versions on receipt
More informationEvaluation of Cancer Outcomes Barwon South West Registry
Evaluation of Cancer Outcomes Barwon South West Registry Data Request Form Applicant details Applicant name: Position: Email: Project start date: Date: Telephone: Project completion date: Project details
More informationRyan Niederkohr, M.D. Slides are not to be reproduced without permission of author
Ryan Niederkohr, M.D. CMS: PET/CT CPT CODES 78814 Limited Area (e.g., head/neck only; chest only) 78815 78816 Regional (skull base to mid-thighs) True Whole Body (skull vertex to feet) SELECTING FIELD
More informationOverview of 2010 Hong Kong Cancer Statistics
Overview of 2010 Hong Kong Cancer Statistics Cancer Registration in Hong Kong The Hong Kong Cancer Registry has since the 1960s been providing population-based cancer data for epidemiological research
More informationPSA nadir post LDR Brachytherapy and early Salvage Therapy. Dr Duncan McLaren UK & Ireland Users Group Meeting 2016
PSA nadir post LDR Brachytherapy and early Salvage Therapy Dr Duncan McLaren UK & Ireland Users Group Meeting 2016 Differences in PSA relapse rates based on definition used PSA ng/ml Recurrence ASTRO Recurrence
More informationSurgical Management of Pulmonary Metastases. Dr AG Jacobs Principal Specialist Dept Cardiothoracic Surgery Steve Biko Academic Hospital
Surgical Management of Pulmonary Metastases Dr AG Jacobs Principal Specialist Dept Cardiothoracic Surgery Steve Biko Academic Hospital Introduction Lungs 2 nd most common site of metastatic deposition
More informationASKLEPIOS Course ADVANCED ONCOLOGIC IMAGING. Education in partnership. September 30 October 1, 2016 Kazan/Russia. myesr.org/esor
YEAR OF ESOR YEAR OF ESOR ADVANCED ONCOLOGIC IMAGING This is implemented with Education in partnership Course information The course is designed for last year residents and recently board-certified radiologists.
More informationOverview of Hong Kong Cancer Statistics of 2015
Overview of Hong Kong Cancer Statistics of 2015 This report summarizes the key cancer statistics of Hong Kong for the year of 2015, which is now available on the website of Hong Kong Cancer Registry. Cancer
More informationSingle Suspected Cancer Pathway Definitions pathway start date
Single Suspected Cancer Pathway Definitions pathway start date Date: March 2018 Version: 1.2.1 Wales Cancer Owner: Network and Welsh Government Status Published 1 P a g e Purpose of Document This document
More informationIRB protocol Yair Lev, MD 11/25/08
IRB protocol Yair Lev, MD 11/25/08 Abdominal and Pelvic CT as a screening modality for occult malignant disease in unprovoked Venous Thromboembolism: A randomized, controlled prospective study. A. Study
More informationAbdomen Sonography Examination Content Outline
Abdomen Sonography Examination Content Outline (Outline Summary) # Domain Subdomain Percentage 1 2 3 Anatomy, Perfusion, and Function Pathology, Vascular Abnormalities, Trauma, and Postoperative Anatomy
More informationNICE guideline on Suspected cancer: recognition and referral (2015) Education package for GPs and Nurse Practitioners Case scenarios
NICE guideline on Suspected cancer: recognition and referral (2015) Education package for GPs and Nurse Practitioners Case scenarios How to use the case scenarios The case scenarios can be used in a training
More informationMacmillan Publications
S1 S2 S3 S3 S3 S4 S5 S6 S7 S8 S8 S9 S10 S11 S11 S12 S13 S14 S15 S17 S18 S19 Bladder Cancer: Non-Invasive, Invasive and Advanced Bone Cancer: Primary, Secondary Colon Cancer, Anal Cancer, Rectal Cancer
More informationPersonalized Medicine: Home Test Kit for Cancer
Personalized Medicine: Home Test Kit for Cancer Joanne I. Yeh, Ph.D Associate Professor, Department of Structural Biology, University of Pittsburgh; Associate Professor, Department of Bioengineering, University
More informationAction to Cure Kidney Cancer Campaign to Fund Kidney Cancer Research
Action to Cure Kidney Cancer 2016 Campaign to Fund Kidney Cancer Research Kidney Cancer Facts 9 th most common cancer in the U.S. Until recently, 3 rd highest rate of increasing incidence of all cancers
More informationESPEN Congress Leipzig 2013
ESPEN Congress Leipzig 2013 Nutrition and cancer: impact on outcome Survival, quality of life, reduced toxicity: what can be achieved in cancer patients? M.A.E. van Bokhorst - de van der Schueren (NL)
More informationThe Cochrane Library Impact Factor Data Pack
The Cochrane Library Impact Factor Data Pack When considering the data presented below, please be aware of the following: The dataset we have used to generate impact factors for individual review groups
More informationManchester Cancer Colorectal Pathway Board: Guidelines for management of colorectal hepatic metastases
Manchester Cancer Colorectal Pathway Board: Guidelines for management of colorectal hepatic metastases Date: April 2015 Date for review: April 2018 1. Principles The recognised specialist HPB MDT for Greater
More informationCutaneous metastases. Thaddeus Mully. University of California, San Francisco Professor, Departments of Pathology and Dermatology
Cutaneous metastases Thaddeus Mully University of California, San Francisco Professor, Departments of Pathology and Dermatology DISCLOSURE OF RELATIONSHIPS WITH INDUSTRY Thaddeus Mully Course C005 Essential
More informationFlattening Filter Free beam
Dose rate effect in external radiotherapy: biology and clinic Marta Scorsetti, M.D. Radiotherapy and Radiosurgery Dep., Istituto Clinico Humanitas, Milan, Italy Brescia October 8th/9th, 2015 Flattening
More informationArmstrong, Bruce (Prof.)
Presenter: Armstrong, Bruce (Prof.) Title of Lecture: Cancer Control Research COMMONWEALTH OF AUSTRALIA Copyright Regulations 1969 WARNING This material has been reproduced and communicated to you by or
More informationTips and tricks. Camillo Aliberti, Massimo Tilli
Tips and tricks Camillo Aliberti, Massimo Tilli Unit of Oncological Diagnostic and Interventional Radiology, Delta Hospital AUSL Ferrara, Ferrara Italy camy.ali@libero.it mtilli72@libero.it Intra-arterial
More informationCLINICAL BIOSTATISTICS
09/06/17 1 Overview and Descriptive Statistics a. Application of statistics in biomedical research b. Type of data c. Graphic representation of data d. Summary statistics: central tendency and dispersion
More informationWest Midlands Sarcoma Advisory Group
West Midlands Sarcoma Advisory Group Guideline for the Initial Investigation and Referral to Specialist Sarcoma Multi Disciplinary Team for Suspected Bone Sarcoma Version History Version Date Brief Summary
More informationCost-effectiveness of using a gene expression profiling test to aid in identifying the primary tumour in patients with cancer of unknown primary
The Pharmacogenomics Journal (2016), 1 15 2016 Macmillan Publishers Limited All rights reserved 1470-269X/16 www.nature.com/tpj ORIGINAL ARTICLE Cost-effectiveness of using a gene expression profiling
More informationBody MRI from the Liver to the Bladder
Body MRI from the Liver to the Bladder I Want You! Audience Participation Methodist Hospital Continuing Education Seminar Jordan Swensson, MD November 7, 2015 Objectives Observe the uses of MRI for organs
More informationCHAPTER 10 CANCER REPORT. Jeremy Chapman. and. Angela Webster
CHAPTER 10 CANCER REPORT Jeremy Chapman and Angela Webster CANCER REPORT ANZDATA Registry 2004 Report This report summarises the cancer (excluding nonmelanocytic skin cancer) experience of patients treated
More informationAMSc Research Methods Research approach IV: Experimental [2]
AMSc Research Methods Research approach IV: Experimental [2] Marie-Luce Bourguet mlb@dcs.qmul.ac.uk Statistical Analysis 1 Statistical Analysis Descriptive Statistics : A set of statistical procedures
More informationNature Getetics: doi: /ng.3471
Supplementary Figure 1 Summary of exome sequencing data. ( a ) Exome tumor normal sample sizes for bladder cancer (BLCA), breast cancer (BRCA), carcinoid (CARC), chronic lymphocytic leukemia (CLLX), colorectal
More informationOncology Clinical Program Update. William Sause Medical Director Oncology Clinical Program
Oncology Clinical Program Update William Sause Medical Director Oncology Clinical Program Outline Cancer Program Background Screening Quality Care New Technology Contact Information Cancer Cases Utah 2011
More informationNuclear medicine in oncology. 1. Diagnosis 2. Therapy
Nuclear medicine in oncology 1. Diagnosis 2. Therapy Diagnosis - Conventional methods - Nonspecific radiopharmaceuticals cumulating in tumours - Specific radiopharmaceuticals (receptor- and immunoscintigraphy)
More informationBrain and Central Nervous System Cancers
Brain and Central Nervous System Cancers NICE guidance link: https://www.nice.org.uk/guidance/ta121 Clinical presentation of brain tumours History and Examination Consider immediate referral Management
More informationCancer and Data in the New NHS May Di Riley, Director Clinical Outcomes
Cancer and Data in the New NHS May 2011 Di Riley, Director Clinical Outcomes Overarching NHS context Financial constraints White Paper GP Commissioning/Commissioning Board Public Health England National
More informationNational Cancer Patient Experience Survey 2016 Technical Documentation July 2017
National Cancer Patient Experience Survey 2016 Technical Documentation July 2017 1 Contents 1. Introduction 2. Scoring 3. Significance Tests (for national data) 4. Case-mix Adjustment (for local data)
More informationNewcastle HPB MDM updated radiology imaging protocol recommendations. Author Dr John Scott. Consultant Radiologist Freeman Hospital
Newcastle HPB MDM updated radiology imaging protocol recommendations Author Dr John Scott. Consultant Radiologist Freeman Hospital This document is intended as a guide to aid radiologists and clinicians
More informationA PHASE 1 STUDY OF TRC105 (ANTI- ADVANCED SOLID TUMORS
ASCO 2011 Abstract Number: 3073 A PHASE 1 STUDY OF TRC105 (ANTI- CD105 ANTIBODY) IN PATIENTS WITH ADVANCED SOLID TUMORS J. W. Goldman, M. S. Gordon, H. Hurwitz, R. Pili, D. S. Mendelson, B. J. Adams, D.
More informationCARCINOMA DEL COLON-RETTO: COSA DICONO LE LINEE GUIDA. Dr.ssa Foltran Luisa Oncologia medica Pordenone
CARCINOMA DEL COLON-RETTO: COSA DICONO LE LINEE GUIDA Dr.ssa Foltran Luisa Oncologia medica Pordenone Convegno Regionale AIOM FVG, Palmanova, 14 Maggio 2016 COLORECTAL CANCER FOLLOW-UP Objectives Intensive
More informationTumor Growth Rate (TGR) A New Indicator of Antitumor Activity in NETS? IPSEN NET Masterclass Athens, 12 th November 2016
1 Tumor Growth Rate (TGR) A New Indicator of Antitumor Activity in NETS? IPSEN NET Masterclass Athens, 12 th November 2016 Philippe RUSZNIEWSKI ENETS Centre of Excellence, Beaujon Hospital, Clichy, France
More informationFrequency(%) KRAS G12 KRAS G13 KRAS A146 KRAS Q61 KRAS K117N PIK3CA H1047 PIK3CA E545 PIK3CA E542K PIK3CA Q546. EGFR exon19 NFS-indel EGFR L858R
Frequency(%) 1 a b ALK FS-indel ALK R1Q HRAS Q61R HRAS G13R IDH R17K IDH R14Q MET exon14 SS-indel KIT D8Y KIT L76P KIT exon11 NFS-indel SMAD4 R361 IDH1 R13 CTNNB1 S37 CTNNB1 S4 AKT1 E17K ERBB D769H ERBB
More informationCorporate Medical Policy
Corporate Medical Policy Pancreas Transplant File Name: Origination: Last CAP Review: Next CAP Review: Last Review: pancreas_transplant 1/2000 5/2017 5/2018 8/2017 Description of Procedure or Service Transplantation
More informationTUMORS OF THE GALLBLADDER AND BILE DUCTS HEPATIC AND
page 1 / 5 page 2 / 5 tumors of the gallbladder pdf Author: wowketodiet. Hello! This is Gallbladder Diet Spanish By wowketodiet. We love to read books and my job is to analyze daily all the novelties in
More informationMEDICAL POLICY Gene Expression Profiling for Cancers of Unknown Primary Site
POLICY: PG0364 ORIGINAL EFFECTIVE: 04/22/16 LAST REVIEW: 07/26/18 MEDICAL POLICY Gene Expression Profiling for Cancers of Unknown Primary Site GUIDELINES This policy does not certify benefits or authorization
More informationNew antiretroviral agents efficacy and safety. Rilpivirine Elvitegravir Both agents with Truvada,+/- cobicistat (not in search terms)
Appendix 4 BHIVA Treatment Guideline update 20 Search protocol: main databases search: rilpivirine and elvitegravir Component Review area Objectives Populations Description New antiretroviral agents efficacy
More informationa) List of KMTs targeted in the shrna screen. The official symbol, KMT designation,
Supplementary Information Supplementary Figures Supplementary Figure 1. a) List of KMTs targeted in the shrna screen. The official symbol, KMT designation, gene ID and specifities are provided. Those highlighted
More informationGuidelines for the Management of Prostate Cancer West Midlands Expert Advisory Group for Urological Cancer
Guidelines for the Management of Prostate Cancer West Midlands Expert Advisory Group for Urological Cancer West Midlands Clinical Networks and Clinical Senate Coversheet for Network Expert Advisory Group
More informationAll India Institute of Medical Sciences, New Delhi, INDIA. Department of Pediatric Surgery, Medical Oncology, and Radiology
All India Institute of Medical Sciences, New Delhi, INDIA Department of Pediatric Surgery, Medical Oncology, and Radiology Clear cell sarcoma of the kidney- rare renal neoplasm second most common renal
More information